@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0033: (2016-03-11 )
MKPSMKRQIAQTGIIHRPLPIETEHALETLAKKKQVLSSRTLFSSKQHVSLEFTHQGAGDFTISGQDEIKLSSPVVMPHWPAGAPDDGDYTNFGNVTISASIGNEDWSGFNRVRIQVFPDFPGVTNPYLMISFKNDGTVKVPDIYGREGVHGVNLINHEWNDVIFEIEGLPRDRMTEMSFSYYLNGPERLTAGTMELFINEIKLEQISEPEISKGWLPQNNTLIYSHNGYSKDMPKVAFCANKHAATTFTIHDKETDKVVFTGKSYQNATETGNFVILDFSDLQTVGEYYLKFADMQTEIFQIGTSEVIWESSIWKSLNFIFCERCGCPVFGKHTTCHADIIAEHDGKQLSFNGGWHDAGDVSQQLIQTAEVTMALYEMAASLPEKEETLRMRLLEEGEWGLDFILKTRFGDGFRATSAGMTRWTDGLVGGMDDAIARVHNQAYENFYCAGIEAYIGSQIADNATMQNHLLRIAEEDLLFAIKELEKHGTSQKPIFWEHTYQTSESLYYATASWAASMVYQLTNKEIYAEKAAEWLDLMLEAQEKAGIRDSETSELYKGFFYRDKSHKVIQHFNHQAREHLYLLALEAALETQPSHAEKQTWLQAVEMYGDYLKKVTRFTKPYPLIPAGLYKKDEYLDEASFHLQHLLIDERAIEEYQLQFEQGIKINDEVALRKFPIWFSFRGNNAILLSAGKAASIAGKILKDKALLDIAEGQLQWVIGMNPFGQSMMHGEGYRYAQQYSVLNGEITGEIPVGMETFRNEDEPYWPEFNNATYKEVWVGNAGKWMSIVADLNKITGKS
Atome Classification :
(20 SA)
.........10........20........30.........40........50........60........70........80........90........100.......-110.......120.......130.......140.......150---....-...160.......170........180.......190.......200.......210.......220.......230.......240--...---------...---------..250.......260---..--..---..----..----270.......280......-.290.-..-----.-...300........310........320........----.330------.-------.----------...----..-------.-340----..-..-----------------------.....350.......-360-------------........370.-----------..-------..-----------..380-----..---.-----------------..-----------------.---.390.......400.......410..-.-------..---..----.-----.-----420---..--.......430.......-------440------...---------......450......---.--460----.......470.......--480.......490..---.....500..--------......510-........520.......530.......540...-...-.550.......-------560.......570.......580.......590...-....600...----------....610....-.-..620.......630........640.......650.......660.......670.......680........690.......700---..-.-----.--....710.......720.......730.......--740------------...--...-------.---------------..---750-------.......-.-.------------760---------..-----------------.------------....---------.------.770...--....780.......-790.......800-------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
P
S
M
K
R
Q
I
A
QTGIIHRPLPI
E
T
E
H
A
L
E
T
L
-
A
K
K
K
Q
V
L
S
SRTLFSSK
Q
H
V
S
L
E
F
T
HQGAG
D
F
T
ISGQD
E
I
KLSS
P
V
VMPHWPAGAPDDGDYTNFG
N
V
T
I
S
A
S
IGNEDWSG-F
N
R
V
R
I
Q
V
FPDFPGVTN
P
Y
L
M
I
S
FKNDG
T
V
KVPDIYGREGV
H
G
---
V
N
LI-NHEWN
D
V
I
F
E
IEGLP-R
D
R
M
T
E
M
S
F
S
Y
YLN
G
P
E
R
L
T
A
G
T
M
E
L
F
I
N
E
I
K
L
E
QISEPEISKGWLPQN
N
T
L
I
Y
SHNGYSKDM
P
K
V
A
F
CA---NKH---------A
A
T
---------
T
F
T
I
HDKET
D
K
V
V
F
----TG--KS---YQ----NA----TETG
N
F
V
I
L
D
F
S
D
L
Q
T
V
G
E
-
Y
Y
L
K
F
-
A
D-----M-Q
T
E
I
-
F
QIGT
S
E
V
I
W
-
E
S
S
I
W
K
S
L
N
F
--
I
F
CERCGC----PVF-------G-------K----------HTT----C
H
-------
A
-
D
------
I
I
-AE-----------------------HDG
K
Q
L
SFNGGWH
D
A
-
G
D
--------------
V
S
Q
Q
L
I
Q
T
A
E
V
T
-----------
M
A
-------
L
Y
-----------
E
M
A
A
S-----LP---
E
-----------------
K
E
-----------------
E
---
T
L
R
M
R
L
LEEGEWG
L
D
F
I
L
K
TRF--GD-G-------
F
R
---AT----S-----A-----G-----M
T
--
R
WTDGLVGG
M
D
D
A
I
A
R
V
-------
H
--------
N
Q
A
---------
Y
E
N
F
Y
C
A
G
I
E
A
Y
IGS---Q--IAD----N
A
T
M
Q
N
H
L
L
R
I
A
E
E
D
L
L
--
F
A
I
K
E
L
E
K
HGTSQK
P
---
I
F
W
E
HT-YQT--------SE
S
L
Y
Y
A
T
--
A
S
W
A
A
S
M
V
Y
Q
LTN
K
E
I
Y
A
E
K
A
A
E
W
L
D
L
M
L
E
A
Q
E
K-AGI-RDS
E
T
S
E
L
Y
K
G
-------
F
FYRDK
S
H
K
V
I
Q
H
F
N
H
Q
A
R
E
H
L
Y
L
L
A
L
E
A
A
LETQPS-
H
A
E
K
Q
T
W
L
Q
A
----------
V
E
M
Y
G
D
Y
L
K
K
V
-
T
-
R
FTKPYPLIPAGLY-
K
K
D
E
Y
L
D
E
A
S
F
H
L
Q
H
L
L
I
D
E
R
A
I
E
E
Y
Q
L
Q
F
EQGIKINDE
V
A
L
R
KF
P
I
W
F
S
-FRGN
N
A
I
L
L
SAG
K
A
A
S
I
A
G
K
----
I
L-K-----D--
K
A
L
L
D
IAEG
Q
L
Q
W
V
I
GMNPFGQSMMHGEG
Y
R
Y
A
Q
--
Q
--------------
Y
SV--LNG-------
E
---------------
I
T---G---------EIPV
G
M
E
-
T
-F------------R-----------NE-----------------D------------EPYW---------P------EFNNA
T
Y
--
K
E
V
W
VGNA
G
K
W
M
S
I
-
V
A
D
L
N
K
ITGKS---------------------------
17
HHSearch
91.70
20%
-54
- C4 -
3H7L
1
?
A:
[2-567]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
L
L
T
N
H
I
G
Y
E
R
L
G
P
K
K
A
I
I
Q
---
T
E
Q
PHL------
S
S
Y
---------
T
A
Q
L
I
C
A
T
S
E
Q
T
V
A
----
T
F
--
A
V
---
E
E
----
Q
G
KVAN
W
H
Q
G
Y
F
Y
L
I
D
F
S
S
F
T
D
S
G
D
-
Y
F
L
Q
V
-
E
D
-----
S
-
R
S
S
T
-
F
T
V
G
E
--
H
I
L
L
N
Q
T
L
S
D
V
I
H
Y
--
F
K
S
Q
R
C
G
G
----
V
F
D
-------
Q
-------------------------
Q
D
-------
R
-
Q
------
V
P
-
V
L
-----------------------
N
A
N
Q
T
A
D
V
H
G
G
W
Y
D
A
S
G
D
--------------
V
S
K
Y
L
S
H
L
S
Y
A
N
YLNPQQ
T
P
M
V
V
W
N
-------
I
L
-----------
K
G
L
S
L
-----
L
E
---
G
-----------------
S
E
DIA--------------
A
---
F
T
R
T
R
L
I
E
E
A
L
F
G
A
D
F
L
V
R
M
Q
N
--
E
K
-
G
-------
F
F
---
Y
M
----
T
-----
V
-----------
F
D
--
K
W
S
K
-------
D
T
A
Q
R
E
I
C
A
Y
---
E
T
QL-----
G
H
K
FDDYQAGFR
Q
G
G
G
V
A
I
A
A
L
A
A
A
S
R
---
L
GV
H
G
E
Y---
D
---
Q
Q
K
Y
R
N
A
A
E
N
G
Y
W
--
H
L
K
E
H
N
T
Q
--
Y
L
N
--------
D
G
E
-
E
-------------
N
I
I
D
E
Y
C
A
L
L
A
S
V
E
L
F
K
A
T
K
E
T
R
Y
L
E
E
S
R
L
W
A
Q
R
L
V
A
R
Q
M
S
-
D
E
---------
Q
I
Q
H
-------
F
W
S
A
N
Q
--
D
G
S
R
P
Y
F
H
A
A
E
A
G
L
P
T
I
A
L
C
E
Y
L
A
I
E
D
D
-
S
V
Q
T
E
S
V
K
C
I
----------
V
N
R
A
C
E
F
E
I
K
I
-
S
N
K
V
T
N
P
F
G
Y
P
R
Q
Y
V
K
-
G
V
N
E
S
K
-
R
D
A
F
F
V
A
H
N
----
N
E
-
S
G
---------------
Y
------
W
---
W
Q
G
E
N
A
R
L
G
S
L
A
T
M
A
Y
L
A
Q
P
----
H
I
-
A
S
Q
E
I
-
Q
--
Q
Q
L
S
V
F
A
Q
D
A
L
N
W
I
V
G
L
N
P
Y
D
M
C
M
L
D
G
H
G
R
N
N
P
D
--
Y
--------------
L
P
Q
Y-
G
F
F
-------
N
---------------
A
K
---
G
---------
G
V
C
N
G
I
T
-
G
-
G
FE----------
D
-----------
E
E
-----------------
D
------------
I
A
F
N
---------
P
PAQKDD
M
L
Q
N
W
R
W
--
G
E
Q
W
I
P
H
G
A
W
Y
L
L
A
-
I
M
S
Q
A
Q
H
-------------------------------
35
Fugue
86.62
17%
-45
- C4 -
3H7L
1
?
A:
[2-577]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
L
L
T
N
H
I
G
Y
E
R
L
G
P
K
K
A
I
I
Q
T
EQ
P
H
L
---------
S
S
Y
---------
T
A
Q
L
I
C
A
T
S
E
Q
T
V
A
----
T
F
--
A
V
---
E
E
QGKV
A
N
----
W
H
Q
G
Y
F
Y
L
I
D
F
S
S
F
T
D
S
G
D
-
Y
F
L
Q
V
-
E
D
-----
S
-
R
S
S
T
-
F
T
V
G
-
E
H
I
L
L
-
N
Q
T
L
S
D
V
I
H
Y
--
F
K
S
Q
R
C
G
---------------
G
-------
V
----------
F
D
Q
----
Q
D
-------
R
-
Q
------
V
P
-
V
L
-----------------------
N
A
N
Q
T
A
D
V
H
G
G
W
Y
D
A
S
G
D
VSKYLSHLSYANYL
N
P
Q
Q
T
P
M
V
V
W
N
I
-----------
L
K
-------
G
L
-----------
S
L
L
E
G
-----
S
E
---
D
-----------------
I
A
-----------------
A
---
F
T
R
T
R
L
I
E
E
A
L
F
G
A
D
F
L
V
R
M
Q
N
--
E
K
-
G
-------
F
F
---
Y
M
----
T
-----
V
-----
F
DKWSK
D
T
--
A
Q
R
E
I
C
A
Y
E
T
Q
L
G
H
K
F
D
-------
D
--------
Y
Q
A
---------
G
F
R
Q
G
G
G
V
A
I
A
A
L
A
A
A
S
R
L
--
G
V
H
----
G
E
Y
D
Q
Q
K
Y
R
N
A
A
E
N
G
Y
W
--
H
L
K
E
H
N
T
Q
Y
L
N
D
G
E
E
---
N
-------------------
I
I
D
E
Y
C
--
A
L
L
A
S
V
E
L
F
K
A
T
K
E
T
R
Y
L
E
E
S
R
L
W
A
Q
R
L
V
A
R
Q
M
S
-
D
E
Q
-
I
Q
-----------------
H
F
W
S
A
N
Q
D
G
S
R
P
Y
F
H
A
A
E
A
G
L
P
T
I
A
L
C
E
Y
L
A
I
E
D
D
-
S
V
Q
T
E
S
V
K
C
I
----------
V
N
R
A
C
E
F
E
I
K
I
-
S
-
N
K
V
T
N
P
F
G
Y
P
R
Q
Y
V
-
K
G
V
N
E
S
K
R
D
A
F
F
V
A
H
----------------------------
N
N
E
S
G
Y
W
-
W
Q
G
E
N
A
R
L
G
S
L
A
T
M
A
Y
L
A
Q
P
HIAS
Q
E
-
I
-----
Q
--
Q
Q
L
S
V
F
A
Q
D
A
L
N
W
I
V
G
L
N
P
Y
D
M
C
M
L
D
G
H
G
R
N
N
P
D
--
Y
--------------
L
P
Q
--
Y
G
F
-------
F
---------------
N
A
---
K
---------
G
G
V
C
N
G
I
-
T
-
G
------------
G
-----------
F
E
-----------------
D
------------
E
E
D
I
A
F
NPPAQKD
D
------
M
L
Q
N
W
R
W
--
G
E
Q
W
I
P
H
G
A
W
Y
L
L
A
-
I
M
S
Q
A
Q
H
I
S
Q
L
A
T
S
K
N
I---------------------
14
HHSearch
85.44
19%
-40
- C4 -
3X17
3
?
B:
[13-559]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
A
Q
I
L
V
N
Q
V
G
Y
H
P
A
T
P
K
Q
A
V
L
A
---
L
A
P
GTAAGIRPG
W
T
P
---------
T
L
Q
I
V
R
A
D
D
G
Q
V
V
W
----
E
G
--
T
M
---
A
G
----
P
S
EDRL
V
S
G
D
T
L
Y
R
A
D
F
T
S
L
T
A
P
G
R
-
Y
V
A
Q
V
-
V
G
G----
P
-
R
S
P
E
-
F
A
I
G
P
---
V
Y
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R
D
V
L
Y
A
A
A
R
S
--
Y
Y
L
Q
R
C
G
V
----
A
I
D
D------
P
-------
I
----------
T
G
V
SHAL
D
H
-------
H
E
D
------
G
Y
-
V
L
VDDPFY-----------------
R
A
G
T
R
L
E
A
T
G
G
W
H
D
A
-
G
D
--------------
Y
G
K
Y
V
T
T
T
A
V
T
A
-----------
A
Q
-------
L
L
-----------
K
A
Y
E
L
-----
Y
P
---
Q
-----------------
A
F
ADGQLHL----------
P
ESG
N
G
V
P
D
I
L
D
E
V
R
W
G
L
E
W
L
F
R
M
Q
R
--
P
D
-
G
-------
A
V
---
Y
H
----
K
-----
L
-----
A
-----
G
L
--
R
W
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G
-
M
I
R
P
E
Q
D
V
Q
R
R
Y
VY-----
R
--------
I
T
T
---------
Q
D
T
A
K
A
A
A
A
W
A
M
A
A
R
---
I
--
F
A
P
F---
D
A
A
F
A
R
K
A
L
A
A
A
E
Q
A
W
R
--
F
L
A
A
S
G
P
I
L
D
Y
P
A
E
D
---
N
S
G
S
G
P
-
Y
D
D
----------
R
D
D
A
D
D
--
R
F
W
A
A
V
E
L
W
V
V
T
G
R
A
E
Y
H
D
Y
I
A
R
M
A
R
T
G
L
----
P
------------
A
Y
A
P
-------
V
S
W
V
N
P
A
A
L
G
Y
F
D
Y
V
T
L
G
--------------
Q
K
G
D
-
P
A
I
R
A
R
L
V
Q
R
----------
I
L
E
G
A
R
S
V
F
Q
T
-
Y
-
E
-
Q
S
G
Y
G
V
P
--------------------
I
L
---------------------
A
G
S
F
-----
H
W
-----
G
S
N
K
E
A
L
A
K
G
M
L
L
L
F
A
H
H
----
L
E
-
P
-----
R
--
P
E
Y
E
R
A
A
L
A
Q
L
D
Y
V
L
G
V
N
P
L
A
K
S
Y
V
T
G
L
G
S
N
P
P
R
--
N
--------------
P
H
H
--
R
L
V
-------
K
---------------
A
S
---
G
---------
V
M
V
P
G
L
L
-
V
-
G
------------
G
-----------
P
N
D----------------
H
PQTKAIRPHMGP
R
G
Y
A
---------
D
------
V
T
D
S
Y
E
T
--
N
E
P
A
I
D
Y
N
A
P
L
V
F
V
-
A
A
H
F
A
S
L
-------------------------------
16
HHSearch
82.92
18%
-38
- C4 -
1UT9
-
?
A:
[210-814]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
P
D
V
R
V
N
Q
V
G
Y
L
P
E
G
K
K
V
A
T
V
V
---
C
N
S
T--------
Q
P
V
---------
K
W
Q
L
K
N
-
A
A
G
V
V
V
L
----
E
G
--
Y
T
---
E
P
----
K
G
LDK-
D
S
Q
D
Y
V
H
W
L
D
F
S
D
F
A
T
E
G
I
G
Y
Y
F
E
L
-
P
T
VNSPT
N
-
Y
S
H
P
-
F
D
I
R
K
--
D
I
Y
-
T
Q
M
K
Y
D
A
L
A
F
--
F
Y
H
K
R
S
G
I
----
P
I
E
M
PYAGGE
Q
-------
W
T---------
R
P
A
----
G
H
-------
I
-
G
IEPNKG
D
T
N
V
P
TWPQDDEYAGIP-----------
Q
K
N
Y
T
K
D
V
T
G
G
W
Y
D
A
-
G
D
--------------
H
G
K
Y
V
V
N
G
G
I
A
V
-----------
W
T
-------
L
M
-----------
N
M
Y
E
R
-----
A
K
---
I
-----------------
R
G
LDNWGPYRDGGMNIPEQ
N
---
N
G
Y
P
D
I
L
D
E
A
R
W
E
I
E
F
F
K
K
M
Q
V
--
T
E
-
K
-------
E
D
PSI
A
G
MVHH
K
-----
I
-----
H
-----
D
F
--
R
W
T
A
L
G
M
L
P
H
E
D
P
Q
P
R
Y
L
R
-----
P
--------
V
S
T
---------
A
A
T
L
N
F
A
A
T
L
A
Q
S
A
R
---
L
--
W
K
D
Y---
D
P
T
F
A
A
D
C
L
E
K
A
E
I
A
W
Q
--
A
A
L
K
H
P
D
I
Y
A
-
E
Y
T
P
GSG
G
P
G
G
G
P
-
Y
N
D
----------
D
Y
V
G
D
E
--
F
Y
W
A
A
C
E
L
Y
V
T
T
G
K
D
E
Y
K
N
Y
L
M
N
S
P
H
Y
L
E
M
P
A
K
M
G--
A
N
G
E
D
--
N
G
L
W
G
C
-------
F
T
W
G
T
T
Q
G
L
G
T
I
T
L
A
L
V
E
--------------
N
G
L
P
-
A
T
D
I
Q
K
A
R
N
N
----------
I
A
K
A
A
D
R
W
L
E
N
-
I
-
E
-
E
Q
G
Y
R
L
P
I
K
Q
A
E
------------------------------------
D
E
R
G
G
Y
-----
P
W
-----
G
S
N
S
F
I
L
N
Q
M
I
V
M
G
Y
A
Y
D
----
F
T
-
G
-----
D
--
S
K
Y
L
D
G
M
F
D
G
I
S
Y
L
L
G
R
N
A
M
D
Q
S
Y
V
T
G
Y
G
E
R
P
L
Q
--
N
--------------
P
H
D
RF
W
T
P
-------
Q
TSK------------
R
F
---
P
---------
A
P
P
P
G
I
I
-
S
G
G
------------
P
-----------
N
S
RFED
P
T
I
N
A
A
VKKDTPP
Q
------------
K
C
F
I
---------
D
------
H
T
D
S
W
S
T
--
N
E
I
T
V
N
W
N
A
P
F
A
W
V
-
T
A
Y
L
D
Q
Y
-------------------------------
37
Fugue
80.70
15%
-29
- C4 -
1UT9
-
?
A:
[208-816]
I
L
P
Q
P
D
V
R
V
N
Q
V
G
Y
L
P
----------------------------
E
G
K
K
V
A
T
V
V
C
N
S
T
Q
P
V
K
W
Q
L
K
N
A
A
--------------------------
G
V
V
V
L
E
G
Y
T
E
P
K
G
L
D
K
-
D
S
Q
D
Y
V
H
W
L
-
D
F
S
D
F
A
T
E
G
I
------------------------------------
G
Y
Y
F
E
L
P
T
V
N
-
S
P
T
N
Y
S
H
P
F
D
I
R
K
D
I
Y
T
Q
M
K
Y
D
A
L
A
F
F
Y
H
K
R
S
G
I
P
I
E
M
P
Y
A
G
G
E
Q
W
T
R
P
A
----
G
H
I
G
I
E
P
N
-------------
K
---------
G
D
T
---------
N
V
P
T
W
P
Q
D
D
E
Y
A
G
I
----
P
Q
--
K
N
---
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
D
V
T
G
G
W
Y
D
A
-
G
D
--------------
H
G
K
Y
V
V
N
G
G
I
A
V
-----------
W
T
-------
L
M
-----------
N
M
Y
E
R
-----
A
K
---
I
R
GLDNWGPYRDGGMNIP
E
Q
-----------------
N
---
N
G
Y
P
D
I
L
D
E
A
R
W
E
I
E
F
F
K
K
M
Q
V
--
T
E
-
K
-------
E
D
---
P
S
----
I
-----
A
-----
G
-----
M
V
HH
K
I
H
D
F
R
W
T
A
L
G
M
L
P
H
E
D
-------
P
--------
Q
P
R
---------
Y
L
R
P
V
S
T
A
A
T
L
N
F
A
A
---
T
--
L
A
Q
----
S
A
R
L
W
K
D
Y
D
P
T
F
A
A
D
C
L
--
E
K
A
E
I
A
W
Q
A
A
L
K
H
P
D
---
I
Y
A
E
Y
T
-
P
G
S
GGPGGGPY
N
D
D
Y
V
G
D
E
--
F
Y
W
A
A
C
E
L
Y
V
T
T
G
K
D
E
Y
K
N
Y
L
M
N
-----------------
S
P
H
Y
L
E
M
P
A
K
-------
M
G
A
N
G
E
D
N
G
L
W
G
C
F
T
W
G
T
T
Q
G
L
G
T
I
T
L
-
A
L
V
E
N
G
L
P
-
A
T
D
I
Q
K
A
R
N
N
----------
I
A
K
A
A
D
R
W
L
E
N
-
I
-
E
E
Q
G
Y
R
L
P
I
K
Q
A
E
D
-
E
R
G
G
Y
P
----------------------------------------------
W
G
S
N
S
F
I
L
N
Q
M
I
V
M
G
Y
A
Y
D
----
F
T
-
G
-----
D
--
S
K
Y
L
D
G
M
F
D
G
I
S
Y
L
L
G
R
N
A
M
D
Q
S
Y
V
T
G
Y
G
E
R
P
L
Q
--
N
PHDRFWTPQTSKRF
P
A
P
--
P
P
G
-------
I
---------------
I
S
---
G
GPNSRFED
P
T
I
N
A
A
V
K
-
K
-
D
------------
T
-----------
P
P
-----------------
Q
------------
K
C
F
I
---------
D
------
H
T
D
S
W
S
T
--
N
E
I
T
V
N
W
N
A
P
F
A
W
V
-
T
A
Y
L
D
Q
Y
T
D
-----------------------------
15
HHSearch
78.58
18%
-45
- C4 -
3GZK
4
?
A:
[7-537]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
I
F
Y
N
Q
V
G
Y
L
I
S
G
D
K
R
F
W
I
Q
---
A
H
E
----------
P
Q
---------
P
F
A
L
R
T
-
P
E
G
Q
A
V
F
----
A
G
--
M
T
---
K
P
----
V
G
-------
G
N
W
Y
V
G
D
F
T
A
L
R
V
P
G
T
-
Y
T
L
T
V
-
G
T
-----
L
--
E
A
R
-
V
V
I
H
R
--
R
A
Y
-
R
D
V
L
E
A
M
L
R
F
--
F
D
Y
Q
L
C
G
V
----
V
L
P
-------
E
DEAGPW-
A
----------
H
G
A
----
C
H
-------
T
-
S
------
D
A
-
K
V
F----------------------
G
T
E
R
A
L
A
C
P
G
G
W
H
D
A
-
G
D
--------------
Y
G
K
Y
T
V
P
A
A
K
A
V
-----------
A
D
-------
L
L
-----------
L
A
H
E
Y
-----
F
P
---
A
-----------------
A
L
A
H
VRPMRSVHR------
A
---
P
H
L
P
P
A
L
E
V
A
R
E
E
I
A
W
L
L
T
M
Q
D
--
P
A
T
G
-------
G
V
---
Y
H
----
K
-----
V
-----
T
-----
T
P
--
S
F
P
P
L
D
T
R
P
E
D
D
D
A
P
L
V
L
S
-----
P
--------
I
S
Y
---------
A
A
T
A
T
F
C
A
A
M
A
H
A
A
L
---
V
--
Y
R
P
F---
D
P
A
L
S
S
C
C
A
D
A
A
R
R
A
Y
A
--
W
L
G
A
H
E
M
Q
P
-
F
H
N
P
D
---
G
I
L
T
G
E
-
Y
G
D
----------
A
E
L
R
D
E
--
L
L
W
A
S
C
A
L
L
R
M
T
G
D
S
A
W
A
R
V
C
E
P
L
L
D
L
------
D
------------
L
P
W
E
-------
L
G
W
A
D
V
A
L
Y
G
V
M
D
Y
L
R
T
P
R
A
-------------
A
V
S
-
D
D
V
R
N
K
V
K
S
R
----------
L
L
R
E
L
D
A
L
A
A
M
-
A
-
E
-
S
H
P
F
G
I
P
M
R
-----------------------------------------
D
D
D
F
-----
I
W
-----
G
S
N
M
V
L
L
N
R
A
M
A
F
L
L
A
E
G
----
V
G
-
V
L----
H
--
P
A
A
H
T
V
A
Q
R
A
A
D
Y
L
F
G
A
N
P
L
G
Q
C
Y
V
T
G
F
G
Q
R
P
V
R
--
H
--------------
P
H
H
R
P
S
V
A
-------
D
DVDHP----------
V
P
---
G
---------
M
V
V
G
G
P
N
-
R
-
H
LQD
E
I
A
R
A
Q
LAG
R
-----------
P
A
-----------------
M
------------
E
A
Y
I
---------
D
------
H
Q
D
S
Y
S
T
--
N
E
V
A
V
Y
W
N
S
P
A
V
F
V
-
I
A
A
L
L
E
A
R
G
R
----------------------------
21
HHSearch
72.03
20%
-35
- C4 -
3WC3
9
?
A:
[6-435]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
Y
-
D
E
V
L
E
K
S
I
L
F
--
Y
E
A
E
R
S
G
D
----
L
-
P
ANNRI--
P
-------
Y
----------
R
G
D
----
S
A
-------
L
-
G
------
D
Q
---------------------------
G
N
Q
G
Q
D
L
T
G
G
W
Y
D
A
-
G
D
--------------
H
V
K
F
G
F
P
M
A
F
A
T
-----------
T
T
-------
L
A
-----------
W
G
I
L
E
-----
F
R
---
D
-----------------
G
Y
E
A
---------------
A
---
G
Q
Y
N
L
A
L
D
S
I
R
W
T
L
N
Y
F
L
K
A
H
V
--
S
D
-
N
-------
E
F
---
Y
G
----
Q
-----
V
-----
G
D
A
N
T
D
H
A
--
Y
W
G
----
R
P
E
D
M
T
M
E
R
P
A
W
S
I
---
S
PS
A
-----
P
G
S
---------
D
L
A
A
E
T
A
A
A
L
A
A
G
Y
L
---
V
--
F
R
D
S---
D
A
A
F
A
N
N
L
L
A
H
S
R
T
L
Y
D
--
F
A
L
N
N
R
G
I
--
Y
S
Q
S
I
---
S
N
A
A
G
F
-
Y
A
S
----------
S
A
Y
E
D
E
--
L
A
W
G
A
A
W
L
Y
R
A
T
E
E
Q
E
Y
L
D
R
A
Y
E
F
G
T
T
T
N
-----------------
T
A
W
A
-------
Y
D
W
N
E
K
I
V
G
Y
Q
--------------
L
L
L
T
T
--
S
A
G
-----
Q
T
D
F
L
P
R
----------
V
E
N
F
L
R
N
W
F
P
G
G
S
-
V
Q
Y
T
P
L
G
L
A
W
--------------------------------------------
L
A
-----
Q
W
-----
G
P
N
R
Y
A
A
N
A
A
F
I
A
L
V
S
A
K
----
Y
N
I
L
-----
A
--
S
E
S
E
Q
F
A
R
S
Q
I
H
Y
M
L
G
D
A
--
G
R
S
Y
V
V
G
F
G
N
N
P
P
Q
--
Q
--------------
P
H
H
RS
S
S
C
-------
P
DQP
A
E
C
D
W
D
E
F
N
---
Q
P
---
G
PNY------
Q
I
L
Y
G
A
L
-
V
-
G
G-----------
P
-----------
D
Q
-----------------
N
------------
D
Q
F
E
---------
D
------
L
R
S
D
Y
I
R
--
N
E
V
A
N
D
Y
N
A
G
F
Q
G
A
-
V
A
A
L
R
A
I
Q
L
-----------------------------
20
HHSearch
71.93
19%
-36
- C4 -
1TF4
1
GUN4_THEFU
A:
[4-446]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
Y
-
A
E
A
L
Q
K
S
M
F
F
--
Y
E
A
Q
R
S
G
K
----
L
P
E
NNRV---
S
-------
W
----------
R
G
D
----
S
G
-------
L
-
N
------
D
G
---------------------------
A
D
V
G
L
D
L
T
G
G
W
Y
D
A
-
G
D
--------------
H
V
K
F
G
F
P
M
A
F
T
A
-----------
T
M
-------
L
A
-----------
W
G
A
I
E
-----
S
P
---
E
-----------------
G
Y
I
R
---------------
S
---
G
Q
M
P
Y
L
K
D
N
L
R
W
V
N
D
Y
F
I
K
A
H
P
--
S
P
-
N
-------
V
L
---
Y
V
----
Q
VGD
G
D
A
-----
D
-----
H
K
--
W
W
G
P
A
----
E
V
M
P
M
E
R
P
S
F
K
V
D
--
P
SC------
P
G
S
---------
D
V
A
A
E
T
A
A
A
M
A
A
S
S
I
---
V
--
F
A
D
D---
D
P
A
Y
A
A
T
L
V
Q
H
A
K
Q
L
Y
T
--
F
A
D
T
Y
R
G
V
Y
--
S
D
C
V
----
P
A
G
A
F
-
Y
N
S
---------
W
S
G
Y
Q
D
E
--
L
V
W
G
A
Y
W
L
Y
K
A
T
G
D
D
S
Y
L
A
K
A
E
Y
E
Y
D
F
L
S
T
E
Q
Q
T
-
D
L
--
R
-----
S
Y
R
W
T
-------
I
A
W
D
D
K
S
Y
G
T
--------------
Y
V
L
L
A
K
E
--
T
-----
G
K
Q
K
Y
I
D
D
----------
A
N
R
W
L
D
Y
W
T
V
G
-----
V
N
G
Q
R
V
P
Y
S
--------------------------
P
G
G
M
--------------------
A
V
L
D
T
W
-
G
A
L
R
Y
A
A
N
T
A
F
V
A
L
V
Y
A
K
----
V
I
-
D
D
P
V
R
-
K
--
Q
R
Y
H
D
F
A
V
R
Q
I
N
Y
A
L
G
D
N
P
R
N
S
S
Y
V
V
G
F
G
N
N
P
P
R
--
N
--------------
P
H
H
RT
A
H
G
-------
S
WTDSIA---------
S
P
AEN
R
---------
H
V
L
Y
G
A
L
-
V
-
G
------------
G
-----------
P
G
SP---------------
N
------------
D
A
Y
T
---------
D
------
D
R
Q
D
Y
V
A
--
N
E
V
A
T
D
Y
N
A
G
F
S
S
A
-
L
A
M
L
V
E
E
Y
G
G
----------------------------
34
Fugue
71.70
18%
-43
* C4 *
1TF4
1
GUN4_THEFU
B:
[1-460]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
A
F
N
Y
-
A
E
A
L
Q
K
S
M
F
F
--
Y
E
A
Q
R
S
G
K
----
L
P
E
----------------NNRVSWRGDS
G
L
N
----
D
G
-------
A
-
D
------
V
-------------------------------
G
L
D
L
T
G
G
W
Y
D
A
-
G
D
HVKF----------
G
F
P
M
A
F
T
A
T
M
L
A
-----------
W
G
-------
A
I
-----------
E
S
P
E
G
-----
Y
I
RSG------------------------------------------
Q
M
P
Y
L
K
D
N
L
R
W
V
N
D
Y
F
I
K
A
H
---
P
S
--PNVLYVQ
V
G
---
D
G
----
D
-----
A
-----
D
-----
H
K
--
W
W
G
P
A
E
V
M
P
M
E
R
P
S
F
K
V
-------
D
--------
P
S
C
---------
P
G
S
D
V
A
A
E
T
A
A
A
M
A
A
---
S
--
S
I
V
FADD
D
P
A
Y
A
A
T
L
V
Q
H
A
K
Q
L
Y
T
--
F
A
D
T
Y
R
G
V
---
Y
S
D
C
---
V
P
A
G
A
F
-
Y
N
S
--------
W
S
G
-
Y
Q
D
E
--
L
V
W
G
A
Y
W
L
Y
K
A
T
G
D
D
S
Y
L
A
K
A
E
Y
E
Y
D
F
L
S
T
E
Q
Q
----------------------------
T
D
L
R
S
Y
R
W
T
I
A
W
D
D
K
S
Y
G
T
Y
V
L
L
A
K
E
T
--
G
------
K
Q
K
Y
I
D
D
----------
A
N
R
W
L
D
Y
W
T
V
G
-
V
-
N
-
G
Q
R
V
P
Y
S
P
G
G
M
------------------------------------------
A
V
--
L
D
T
W
G
A
-
L
R
Y
A
A
N
T
A
F
V
A
L
V
Y
A
K
V
I
D
D
----
P
V
-
R
-----
K
--
Q
R
Y
H
D
F
A
V
R
Q
I
N
Y
A
L
G
D
N
P
R
N
S
S
Y
V
V
G
F
G
N
N
P
P
R
NP
H
--------------
H
R
T
--
A
H
G
-------
S
---------------
W
T
---
D
---------
S
I
A
S
P
A
E
-
N
-
R
------------
H
VLYGALVGGPG
S
P
-----------------
N
------------
D
A
Y
T
---------
D
------
D
R
Q
D
Y
V
A
--
N
E
V
A
T
D
Y
N
A
G
F
S
S
A
-
L
A
M
L
V
E
E
Y
G
G
T
PLADFPPTEEPDG--------------
43
Fugue
69.13
18%
-32
- C1 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
---
A
M
N
S
L
F
A
S
T
A
---
R
G
L
E
E
L
L
K
T
E
L
E
N
L
G
A
V
E
C
Q
V
V
Q
G
G
V
H
F
K
G
D
T
R
L
V
Y
Q
S
L
M
W
S
------------
R
L
A
S
R
I
M
L
P
L
--------
G
E
C
K
V
Y
S
D
L
D
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
----------
P
G
A
T
---
F
A
V
H
F
S
G
L
N
D
T
I
R
N
S
Q
Y
G
A
M
K
V
K
-----
D
A
I
-
V
D
A
F
T
R
K
N
L
P
R
P
N
V
D
-
R
D
A
-
P
D
I
R
V
N
V
W
L
H
K
E
------
T
A
S
I
A
L
D
-----------
L
S
G
D
G
L
H
L
R
G
---
Y
R
D
R
A
G
I
A
P
I
----------------------------------------
K
E
T
L
A
A
A
I
----
V
M
--
R
S
---
G
W
----
Q
P
--------
G
T
P
L
L
D
P
------------------------------
M
C
G
S
G
T
L
L
I
-
E
A
A
M
L
A
T
D
R
A
PG
L
H
R
G
R
W
G
F
----
S
G
W
-------
A
-------
Q
----------
H
D
--------------------------------------------------------------
E
A
I
W
-
Q
E
--------------
V
K
A
E
A
Q
T
R
A
R
K
G
-----------
L
A
-------
E
Y
-----------
S
S
H
F
Y
-----
G
S
---
D
-----------------
S
D
-----------------
A
---
R
V
I
Q
R
A
R
T
N
A
R
L
A
-------
G
I
--
G
E
-
L
-------
I
T
---
F
E
----
V
-----
K
-----
D
-----
V
A
--
Q
L
T
N
P
L
P
K
G
P
Y
G
T
V
L
S
N
-------
P
--------
P
Y
G
---------
E
S
E
P
A
L
I
A
L
H
S
L
L
G
R
---
I
--
M
K
N
----
Q
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
---
L
D
C
V
Q
K
N
Y
H
V
--------
A
E
S
M
V
------------------
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
-
E
G
I
----
E
C
Y
R
L
Y
D
A
DLPEYN
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
H
K
A
R
Q
R
L
F
D
I
I
--
A
A
T
I
S
V
L
G
-
I
A
P
N
K
L
V
L
K
T
----------
R
E
E
K
G
E
F
-
L
E
V
-
T
-
E
Y
N
-------
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
------
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
S
K
G
---------
K
D
F
L
N
L
F
S
-
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
-----
V
D
-
M
-----
S
--
R
T
Y
L
E
W
A
E
R
N
L
R
L
-
N
G
L
T
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
--
E
--------------
A
N
E
--
Q
F
D
-------
L
---------------
I
F
---
I
---------
D
P
P
T
F
S
A
F
D
-
V
------------
Q
-----------
R
D
-----------------
H
------------
L
A
L
M
---------
K
------
D
L
K
R
L
L
R
AG
G
T
I
M
F
S
N
N
K
R
G
F
R
M
D
L
D
G
L
A
K
L
G
L
K
A
Q
E
ITQKTLSQDFARNRQIH
N
C
W
L
I
T
AA
18
HHSearch
68.41
18%
-42
- C4 -
1IA6
4
?
A:
[4-431]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
Y
-
S
T
A
L
K
D
S
I
I
F
--
F
D
A
N
K
C
G
P
----
Q
A
G
ENNVF--
D
-------
W
----------
R
G
A
----
C
H
-------
T
-
T
------
D
G
-
S
--------------------------
D
V
G
V
D
L
T
G
G
Y
H
D
A
-
G
D
--------------
H
V
K
F
G
L
P
Q
G
Y
S
A
-----------
A
I
-------
L
G
-----------
W
S
L
Y
E
-----
F
K
---
E
-----------------
S
F
D
A
---------------
T
---
G
N
T
T
K
M
L
Q
Q
L
K
Y
F
T
D
Y
F
L
K
S
H
P
--
N
S
-
T
-------
T
F
---
Y
Y
----
Q
-----
V
GE
G
N
A
D
-----
H
T
--
Y
W
G
----
A
P
E
E
Q
T
G
Q
R
P
-------
S
L
Y
K
A
D
PSS
P
A
S
---------
D
I
L
S
E
T
S
A
A
L
T
L
M
Y
L
---
N
--
Y
K
N
I---
D
S
A
Y
A
T
K
C
L
N
A
A
K
E
L
Y
A
--
M
G
K
A
N
Q
G
V
G
----------
N
G
Q
S
F
-
Y
Q
A
----------
T
S
F
G
D
D
--
L
A
W
A
A
T
W
L
Y
T
A
T
N
D
S
T
Y
I
T
D
A
E
Q
F
I
T
L
------
N
-
K
-
M
-------
Q
D
K
W
T
-------
M
C
W
D
D
M
Y
V
P
A
A
L
R
L
----------------
A
Q
I
T
G
-----
K
Q
I
Y
K
D
A
----------
I
E
F
N
F
N
Y
W
K
T
Q
-
V
-
T
-
T
T
P
---------------------------------
G
G
L
--------------------
K
W
L
S
N
W
-
G
V
L
R
Y
A
A
A
E
S
M
V
M
L
V
Y
C
K
----
Q
N
-
P
-----
D
--
Q
S
L
L
D
L
A
K
K
Q
V
D
Y
I
L
G
D
N
P
A
N
M
S
Y
I
I
G
Y
G
S
N
W
C
I
--
H
--------------
P
H
H
RA
A
N
G
YTYADNA
K
---------------
P
A
---
K
---------
H
L
L
T
G
A
L
-
V
-
G
G-----------
P
-----------
D
Q
-----------------
N
------------
D
K
F
L
---------
D
------
D
A
N
Q
Y
Q
Y
--
T
E
V
A
L
D
Y
N
A
G
L
V
G
V
-
L
A
G
A
I
K
F
F
G
-----------------------------
22
HHSearch
66.56
17%
-36
- C4 -
1G87
7
GUNG_CLOCE
A:
[4-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
Y
-
G
E
A
L
Q
K
S
I
M
F
--
Y
E
F
Q
R
S
G
D
----
L
-
P
-------
A
DKRDN--
W
----------
R
D
D
----
S
G
-------
M
-
K
------
D
G
---------------------------
S
D
V
G
V
D
L
T
G
G
W
Y
D
A
-
G
D
--------------
H
V
K
F
N
L
P
M
S
Y
T
S
-----------
A
M
-------
L
A
-----------
W
S
L
Y
E
-----
D
K
---
D
-----------------
A
Y
D
K
---------------
S
---
G
Q
T
K
Y
I
M
D
G
I
K
W
A
N
D
Y
F
I
K
C
N
P
--
T
P
-
G
-------
V
Y
---
Y
Y
----
Q
-----
V
GD
G
G
K
D
-----
H
S
--
W
W
G
P
A
----
E
V
M
Q
M
E
R
P
S
F
K
V
D
AS
K
--------
P
G
S
---------
A
V
C
A
S
T
A
A
S
L
A
S
A
A
V
---
V
--
F
K
S
S---
D
P
T
Y
A
E
K
C
I
S
H
A
K
N
L
F
D
--
M
A
D
K
A
K
S
D
A
G
Y
-------
T
A
A
S
G
Y
-
Y
S
S
----------
S
S
F
Y
D
D
--
L
S
W
A
A
V
W
L
Y
L
A
T
N
D
S
T
Y
L
D
K
A
E
S
Y
V
P
N
W
G
K
E
Q
Q
T
-
D
I
I
-------
A
Y
K
W
G
-------
Q
C
W
D
D
V
H
Y
G
A
E
L
L
L
A
----------------
K
L
T
N
-----
K
Q
L
Y
K
D
S
----------
I
E
M
N
L
D
F
W
T
T
G
-----
V
N
G
T
R
V
S
Y
T
--------------------------
P
K
G
L
--------------------
A
W
L
F
Q
W
-
G
S
L
R
H
A
T
T
Q
A
F
L
A
G
V
Y
A
E
----
W
E
-
G
CTPSK
V
--
S
V
Y
K
D
F
L
K
S
Q
I
D
Y
A
L
G
S
T
--
G
R
S
F
V
V
G
Y
G
V
N
P
P
Q
--
H
--------------
P
H
H
RT
A
H
G
-------
S
WTDQMTSPT------
Y
H
---
R
---------
H
T
I
Y
G
A
L
-
V
-
G
G-----------
P
-----------
D
N
-----------------
A
------------
D
G
Y
T
---------
D
------
E
I
N
N
Y
V
N
--
N
E
I
A
C
D
Y
N
A
G
F
T
G
A
-
L
A
K
M
Y
K
H
S
G
G
----------------------------
19
HHSearch
66.25
18%
-32
- C4 -
1KS8
1
?
A:
[3-431]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
Y
-
K
Q
V
L
R
D
S
L
L
F
--
Y
E
A
Q
R
S
G
R
----
L
P
A
DQKV---
T
-------
W
----------
R
K
D
----
S
A
-------
L
-
N
------
D
Q
---------------------------
G
D
Q
G
Q
D
L
T
G
G
Y
F
D
A
-
G
D
--------------
F
V
K
F
G
F
P
M
A
Y
T
A
-----------
T
V
-------
L
A
-----------
W
G
L
I
D
-----
F
E
---
A
-----------------
G
Y
S
S
---------------
A
---
G
A
L
D
D
G
R
K
A
V
K
W
A
T
D
Y
F
I
K
A
H
T
--
S
Q
-
N
-------
E
F
---
Y
G
----
Q
-----
V
GQ
G
D
A
D
-----
H
A
--
F
W
G
----
R
P
E
D
M
T
M
A
R
P
A
Y
K
I
D
TS
R
--------
P
G
S
---------
D
L
A
G
E
T
A
A
A
L
A
A
A
S
I
---
V
--
F
R
N
V---
D
G
T
Y
S
N
N
L
L
T
H
A
R
Q
L
F
D
--
F
A
N
N
Y
R
G
K
Y
--
S
D
S
I
---
T
D
A
R
N
F
-
Y
A
S
----------
A
D
Y
R
D
E
--
L
V
W
A
A
A
W
L
Y
R
A
T
N
D
N
T
Y
L
N
T
A
E
S
L
Y
D
E
F
G
L
Q
N
--------------
W
G
G
G
-------
L
N
W
D
S
K
V
S
G
V
Q
V
L
L
A
----------------
K
L
T
N
-----
K
Q
A
Y
K
D
T
----------
V
Q
S
Y
V
N
Y
L
I
N
N
-
Q
-
Q
-
K
T
P
K
G
L
L
Y
I
-------------------------------------------------
D
M
W
-----
G
T
L
R
H
A
A
N
A
A
F
I
M
L
E
A
A
E
----
L
G
L
S
-----
A
--
S
S
Y
R
Q
F
A
Q
T
Q
I
D
Y
A
L
G
D
G
--
G
R
S
F
V
C
G
F
G
S
N
P
P
T
--
R
--------------
P
H
H
RS
S
S
C
-------
P
PAPATCD
W
N
T
F
N
SPD
P
N
---
Y
---------
H
V
L
S
G
A
L
-
V
-
G
G-----------
P
-----------
D
Q
-----------------
N
------------
D
N
Y
V
---------
D
------
D
R
S
D
Y
V
H
--
N
E
V
A
T
D
Y
N
A
G
F
Q
S
A
-
L
A
A
L
V
A
L
-------------------------------
23
HHSearch
66.21
16%
-33
- C4 -
2YIK
4
?
A:
[38-518]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
Y
-
A
K
A
L
Q
Y
S
M
F
F
--
Y
D
A
N
M
C
G
T
----
G
V
D
-------
E
NSLLS--
W
----------
R
G
D
----
C
H
-------
V
-
Y
------
D
A
-
R
L
PLDSQNTNMS
D
G
F
I
S
S
N
RSVLDP
D
G
D
G
K
V
D
V
S
G
G
F
H
D
A
-
G
D
--------------
H
V
K
F
G
L
P
E
A
Y
A
A
-----------
S
T
-------
V
G
-----------
W
G
Y
Y
E
-----
F
K
---
D
-----------------
Q
F
R
A
---------------
T
---
G
Q
A
V
H
A
E
V
I
L
R
Y
F
N
D
Y
F
M
R
C
T
F
R
D
A
S
-
G
NVV----
A
F
---
C
H
----
Q
-----
V
GD
G
D
I
D
-----
H
A
--
F
W
G
----
A
P
E
N
D
T
M
F
R
R
G
W
F
I
---
T
KEK-----
P
G
T
---------
D
I
I
S
A
T
A
A
S
L
A
I
N
Y
M
---
N
--
F
K
D
T---
D
P
Q
Y
A
A
K
S
L
D
Y
A
K
A
L
F
D
--
F
A
E
K
N
P
K
G
V
-
V
Q
-
G
E
---
D
G
P
K
G
Y
-
Y
G
S
----------
S
K
W
Q
D
D
--
Y
C
W
A
A
A
W
L
Y
L
A
T
Q
N
E
H
Y
L
D
E
A
F
K
Y
Y
D
Y
Y
A
----
P
------------
P
G
W
I
-------
H
C
W
N
D
V
W
S
G
T
A
-
C
I
L
A
E
I
N
D
---------
L
Y
--
D
K
D
S
Q
N
F
E
D
R
Y
K
R
A
S
NKNQWEQID
F
W
K
P
I
Q
D
L
L
D
K
-----
W
S
G
G
G
I
-----------------------------------------
T
V
T
P
G
G
Y
-----
V
F
L
N
Q
W
-
G
S
A
R
Y
N
T
A
A
Q
L
I
A
L
V
Y
D
K
----
H
H
-
G
-----
D
TP
S
K
Y
A
N
W
A
R
S
Q
M
D
Y
L
L
G
K
N
P
L
N
R
C
Y
V
V
G
Y
S
S
N
S
V
K
--
Y
--------------
P
H
H
RA
A
S
G
-------
L
KDANDSS--------
P
H
---
K
---------
Y
V
L
Y
G
A
L
-
V
-
G
G-----------
P
-----------
D
A
-----------------
S
------------
D
Q
H
V
---------
D
------
R
T
N
D
Y
I
Y
--
N
E
V
A
I
D
Y
N
A
A
F
V
G
A
-
C
A
G
L
Y
R
F
F
G
D
----------------------------
5
PsiBlast_PDB
52.12
24%
-34
- C3 -
3X17
2
?
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
G
A
Q
I
L
V
N
Q
V
G
Y
H
P
A
T
P
K
Q
A
V
L
A
---
L
A
P
---------
G
T
A
AGIRPGWTP
T
L
Q
I
V
R
A
D
D
G
Q
V
V
W
EGTM
A
G
--
P
S
---
E
D
----
R
L
----
V
S
G
D
T
L
Y
R
A
D
F
T
S
L
T
A
P
G
R
-
Y
V
A
Q
V
V
G
G
-----
P
-
R
S
P
E
-
F
A
I
G
P
---
V
Y
-
R
D
V
L
Y
A
A
A
R
S
--
Y
Y
L
Q
R
C
G
V
AIDD
P
I
T
-------
G
V------
S
----------
H
A
L
----
D
H
HEDGYVL
V
-
D
------
D
P
-
F
Y
-----------------------
R
A
G
T
R
L
E
A
T
G
G
W
H
D
A
-
G
D
--------------
Y
G
K
Y
V
T
T
T
A
-
V
T
-----------
A
A
QLLKAYE
L
Y
-----------
P
Q
A
F
A
DGQLH
L
P
---
E
-----------------
S
G
-----------------
N
---
G
V
-
P
D
I
L
D
E
V
R
W
G
L
E
W
L
F
R
M
Q
R
--
P
D
-
G
-------
A
V
---
Y
H
----
K
-----
L
-----
A
-----
G
L
--
R
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
47.78
19%
-50
- C3 -
3K4Z
4
?
A:
[82-280]
------------------------------------------------------------------------------------------------------------
G
H
-
T
Y
R
V
R
L
K
I
W
A
D
A
S
--
C
K
V
Y
I
K
I
G
--
Q
M
G
E
-----
P
Y
A
-
E
Y
W
N
N
KW
S
P
Y
T
L
T
A
G
K
V
L
E
I
D
E
T
F
V
M
D
K
P
T
D
D
T
C
--
E
F
T
F
H
L
G
G
E
L
A
-
A
T
P
P
Y
T
V
Y
L
D
D
V
S
L
Y
D
P
-
E
Y
T
K
P
V
E
Y
I
L
P
Q
P
D
V
R
V
N
Q
V
G
Y
L
P
E
G
K
K
V
A
T
V
V
---
C
N
S
T--------
Q
P
V
---------
K
W
Q
L
K
N
-
A
A
G
V
V
V
L
----
E
G
--
Y
T
---
E
P
----
K
G
LD------
Y
V
H
W
L
D
F
S
D
F
A
T
E
G
I
G
Y
Y
F
E
L
-
P
T
VNSPT
N
-
Y
S
H
P
-
F
D
I
R
K
--
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
44.03
23%
-16
- C3 -
1CLC
-
?
?:
[25-124]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
T
K
V
S
A
A
K
I
T
E
N
-
Y
Q
F
D
S
R
I
R
L
N
S
I
G
F
I
P
N
H
S
K
K
A
T
I
A
---
A
N
-----------
C
S
---------
T
F
Y
V
V
K
-
E
D
G
T
I
V
Y
----
T
G
T
A
T
S
---
M
F
----
D
N
----
D
T
K
E
T
V
Y
I
A
D
F
S
S
V
N
E
E
G
T
-
Y
Y
L
A
V
-
P
G
-----
V
G
K
S
V
N
-
F
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
43.59
18%
-17
- C4 -
3EVY
-
?
A:
[662-744]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
P
Y
E
K
L
V
E
R
F
N
E
M
A
A
E
F
L
S
Y
F
P
T
V
K
S
V
G
N
L
E
S
-
E
L
D
K
R
R
F
V
I
L
----------
F
R
A
M
L
R
L
R
N
E
V
-
K
-
G
Y
N
E
---------------------
F
D
A
E
D
L
T
I
E
E
Q
R
F
A
D
Y
Q
S
K
Y
L
D
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
43.24
24%
-23
- C3 -
4CJ0
4
GUND_CLOTM
A:
[58-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
D
G
T
I
V
Y
----
T
G
--
T
A
T
S
M
F
D
----
N
D
----
T
K
E
T
V
Y
-
I
A
D
F
S
S
V
N
E
E
G
T
-
Y
Y
L
A
V
-
P
G
-----
V
-
G
K
S
V
N
F
K
I
A
M
N
--
V
Y
-
E
D
A
F
K
T
A
M
L
G
--
M
Y
L
L
R
C
G
T
----
S
V
S
-------
A
T
Y
NG
I
H
Y
S
----------
H
G
P
----
C
H
-------
T
-
N
DAYLDY
I
N
-
G
Q
-----------------------
H
T
K
K
D
S
T
--
K
G
W
H
D
A
-
G
D
--------------
Y
N
K
Y
V
V
N
A
G
I
T
V
-----------
G
S
-------
M
F
L
A
W
E
H
F
K
DQLE
P
V
A
L
E
-----
I
P
---
E
-----------------
K
N
-----------------
N
---
S
I
P
-
D
F
L
D
E
L
K
Y
E
I
D
W
I
L
T
M
Q
Y
--
P
D
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
43.12
24%
-21
- C3 -
1CLC
2
GUND_CLOTM
A:
[72-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
D
G
T
I
V
Y
----
T
G
--
T
A
T
S
M
F
D
----
N
D
----
T
K
E
T
V
Y
-
I
A
D
F
S
S
V
N
E
E
G
T
-
Y
Y
L
A
V
-
P
G
-----
V
-
G
K
S
V
N
F
K
I
A
M
N
--
V
Y
-
E
D
A
F
K
T
A
M
L
G
--
M
Y
L
L
R
C
G
T
----
S
V
S
-------
A
T
Y
NG
I
H
Y
S
----------
H
G
P
----
C
H
-------
T
-
N
DAYLDY
I
N
-
G
Q
-----------------------
H
T
K
K
D
S
T
--
K
G
W
H
D
A
-
G
D
--------------
Y
N
K
Y
V
V
N
A
G
I
T
V
-----------
G
S
-------
M
F
L
A
W
E
H
F
K
DQLE
P
V
A
L
E
-----
I
P
---
E
-----------------
K
N
-----------------
N
---
S
I
P
-
D
F
L
D
E
L
K
Y
E
I
D
W
I
L
T
M
Q
Y
--
P
D
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------