@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0035: (2016-03-11 )
MKPTMMTYINEEEEMCRAILANFQTNAEKLESLVKNGAKEWLILATGSSLNAAQSAKYYIENIADVRITVEEPFNHLYYEKLSNHLDLVIGISQSGQSTSTISALERVKKEASVPVVALTSDVTSEIAEFADITLDIGSGKERVGYVTKGFTATVLTLMLTGLHFAYKTAQIDETKFNNEINAFSRATNAIPATIAETEAFYERWQEEFATAPKFTAIGYGPTVGTCKEFETKFSETVRVPSQGLDLEAFMHGPYLEVNPQHRIFFLETESAVTERLVALRNYESKYTPFTYTVKFGTAGNDRTLLIPADLDEYQAPFLMILPFQILAHHIAELKGNKLTERIYTDFGVAMKSKTKPGDYA
Atome Classification :
(20 SA)
.........10........20...---------.-------...-.30.....-...40.----------.......50........60........70........80.........90........100.......110...-.....120.......130.......140.......150.......160.......170.......180.......190.......200....---.---..210.......220.......230.......240.......250.......260.....--------..--270...------...-.----280.......290........-----300.---......310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKP
T
M
M
TYIN
E
E
E
E
M
C
R
A
I
L
A
NFQ---------T-------
N
A
E
-
K
L
E
S
L
V
KN-GAK
E
W
L
----------
I
L
ATGSSL
N
A
A
Q
S
A
K
Y
Y
I
ENI
A
D
V
R
I
T
VEE
P
F
N
H
L
Y
Y
E
-
K
L
SNHL
D
L
V
I
G
ISQSGQST
S
T
I
S
A
L
E
R
V
K
K
E
-ASV-
P
V
V
A
L
T
S
D
V
T
S
E
I
A
E
F
A
D
I
T
L
DIGSGK
E
R
V
G
Y
VTK
G
F
T
A
T
V
L
T
L
M
L
T
G
L
H
F
A
Y
K
TAQIDETKFNN
E
I
N
A
F
S
RATNAIP
A
T
I
A
E
T
E
A
F
Y
E
R
W
Q
---
E
---
E
FATAPK
F
T
AIGYGPTVG
T
C
K
E
F
E
T
K
F
S
E
TVRVPSQGL
D
L
E
A
FMHGP
Y
L
E
VNPQ
H
R
I
F
F
L
--------ET--
E
S
A
V
T
E
------
R
L
V
-
A
----
L
RNYESKYT
P
F
T
-
Y
T
V
K
FGTA-----GN
D
R
---
T
L
L
IPAD
L
D
EYQA
P
F
L
M
I
L
P
F
Q
I
L
A
H
H
I
A
E
LKGN
K
L
T
E
R
I
Y
T
D
FGVAMKSKTKPGDYA
24
HHSearch
99.83
94%
-100
- C1 -
2AML
2
?
A:
[13-373]
M
K
P
T
M
M
T
Y
I
N
E
E
E
E
M
C
R
V
I
L
A
D
F
Q
---------
T
-------
N
A
E
-
K
L
E
S
L
V
K
N
-
G
A
K
E
W
L
----------
I
L
A
T
G
S
S
L
N
A
A
Q
S
A
K
Y
Y
I
E
N
L
A
D
V
R
I
T
I
E
E
P
F
N
H
L
Y
Y
E
-
K
L
S
S
H
L
D
L
V
I
G
I
S
Q
S
G
Q
S
T
S
T
I
S
A
L
E
R
V
K
-
K
E
A
S
V
-
P
V
V
A
L
T
S
D
V
T
S
E
I
A
E
F
A
D
I
T
L
D
I
G
S
G
K
E
R
V
G
Y
V
T
K
G
F
T
A
T
V
L
T
L
M
L
T
G
L
H
F
A
Y
K
T
V
Q
I
D
E
T
R
F
N
N
E
I
S
A
F
S
R
A
I
D
A
I
P
A
T
I
A
E
T
E
A
F
Y
E
R
W
Q
---
E
---
E
F
A
T
A
P
K
F
T
A
I
G
Y
G
P
T
V
G
T
C
K
E
F
E
T
K
F
S
E
T
V
R
V
P
S
Q
G
L
D
L
E
A
F
M
H
G
P
Y
L
E
V
N
P
Q
H
R
I
F
F
L
--------
E
T
--
A
S
A
V
T
E
------
R
L
V
-
L
----
L
R
D
Y
E
S
K
Y
T
P
F
T
-
Y
T
V
K
F
G
K
G
-----
E
D
D
R
---
T
L
V
I
P
T
D
L
D
E
Y
Q
A
P
F
L
M
I
L
P
F
Q
I
L
A
H
H
I
A
E
L
K
G
N
K
L
T
E
R
I
Y
T
D
F
G
V
A
M
K
S
K
T
K
P
G
D
Y
A
1
PsiBlast_PDB
99.13
92%
-99
- C1 -
2AML
2
?
A:
[14-373]
-
K
P
T
M
M
T
Y
I
N
E
E
E
E
M
C
R
V
I
L
A
D
F
Q
---------
T
-------
N
A
E
-
K
L
E
S
L
V
K
N
-
G
A
K
E
W
L
----------
I
L
A
T
G
S
S
L
N
A
A
Q
S
A
K
Y
Y
I
E
N
L
A
D
V
R
I
T
I
E
E
P
F
N
H
L
Y
Y
E
-
K
L
S
S
H
L
D
L
V
I
G
I
S
Q
S
G
Q
S
T
S
T
I
S
A
L
E
R
V
K
K
E
-
A
S
V
-
P
V
V
A
L
T
S
D
V
T
S
E
I
A
E
F
A
D
I
T
L
D
I
G
S
G
K
E
R
V
G
Y
V
T
K
G
F
T
A
T
V
L
T
L
M
L
T
G
L
H
F
A
Y
K
T
V
Q
I
D
E
T
R
F
N
N
E
I
S
A
F
S
R
A
I
D
A
I
P
A
T
I
A
E
T
E
A
F
Y
E
R
W
Q
---
E
---
E
F
A
T
A
P
K
F
T
A
I
G
Y
G
P
T
V
G
T
C
K
E
F
E
T
K
F
S
E
T
V
R
V
P
S
Q
G
L
D
L
E
A
F
M
H
G
P
Y
L
E
V
N
P
Q
H
R
I
F
F
L
--------
E
T
--
A
S
A
V
T
E
------
R
L
V
-
L
----
L
R
D
Y
E
S
K
Y
T
P
F
T
-
Y
T
V
K
F
G
K
G
-----
E
D
D
R
---
T
L
V
I
P
T
D
L
D
E
Y
Q
A
P
F
L
M
I
L
P
F
Q
I
L
A
H
H
I
A
E
L
K
G
N
K
L
T
E
R
I
Y
T
D
F
G
V
A
M
K
S
K
T
K
P
G
D
Y
A
26
HHSearch
65.36
28%
-79
- C1 -
3G68
6
?
A:
[1-345]
-
G
M
T
I
Q
D
Y
M
L
E
T
P
V
R
M
R
E
I
I
S
N
A
D
---------
S
-------
L
F
N
-
E
V
--
K
R
T
--
N
L
K
K
I
I
----------
I
T
G
S
G
T
S
Y
H
S
G
V
Q
V
Q
P
Y
L
Q
N
L
L
D
I
D
V
V
K
M
Y
P
F
M
I
T
E
D
T
F
K
F
D
N
E
N
T
L
V
V
G
V
S
Q
G
G
S
S
Y
S
T
Y
N
A
M
K
L
A
E
-
D
-
K
G
C
-
K
I
A
S
M
A
G
C
K
N
A
L
I
D
E
I
S
D
Y
I
L
T
V
N
C
G
E
E
K
S
G
A
K
T
K
G
Y
Y
C
T
K
L
N
L
M
L
L
G
L
Q
I
A
R
E
K
G
I
I
S
S
E
K
Y
N
E
E
I
N
K
I
L
D
A
I
N
R
F
E
A
V
Y
K
L
S
K
Q
W
I
E
R
N
K
---
E
---
K
L
V
N
S
K
E
I
R
I
I
G
H
S
D
I
Y
G
D
T
L
E
A
A
L
K
L
L
E
T
M
R
I
P
V
T
G
Y
E
F
E
E
F
I
H
G
I
Y
N
A
I
N
S
D
S
T
I
F
I
L
--------
D
T
--
G
K
--
E
P
------
R
V
T
-
K
----
M
I
D
V
L
S
G
W
T
E
N
V
-
F
A
I
G
R
D
V
T
-----
E
N
D
K
---
N
L
K
I
D
I
T
D
N
P
Y
Y
Q
T
F
N
F
I
V
P
I
Q
L
I
C
G
E
I
P
T
L
R
G
V
D
P
S
V
P
K
D
T
R
F
H
M
K
L
----------
4
PsiBlast_PDB
64.38
22%
-87
- C1 -
4AMV
1
GLMS_ECOLI
A:
[279-598]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
----
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
9
PsiBlast_PDB
64.22
22%
-87
- C1 -
2J6H
2
GLMS_ECOLI
A:
[278-597]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
----
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
2
PsiBlast_PDB
62.96
29%
-76
- C1 -
3G68
4
?
A:
[20-330]
---------------------------------
S
-------
N
A
D
-
S
L
F
N
E
V
K
R
T
N
L
K
K
I
I
----------
I
T
G
S
G
T
S
Y
H
S
G
V
Q
V
Q
P
Y
L
Q
N
L
L
D
I
D
V
V
K
M
Y
P
F
M
I
T
E
D
T
F
K
F
D
N
E
N
T
L
V
V
G
V
S
Q
G
G
S
S
Y
S
T
Y
N
A
-
M
K
L
A
E
D
-
K
G
C
-
K
I
A
S
M
A
G
C
K
N
A
L
I
D
E
I
S
D
Y
I
L
T
V
N
C
G
E
E
K
S
G
A
K
T
K
G
Y
Y
C
T
K
L
N
L
M
L
L
G
L
Q
I
A
R
E
K
G
I
I
S
S
E
K
Y
N
E
E
I
N
K
I
L
D
A
I
N
R
F
E
A
V
Y
K
L
S
K
Q
W
I
E
R
N
K
---
E
---
K
L
V
N
S
K
E
I
R
I
I
G
H
S
D
I
Y
G
D
T
L
E
A
A
L
K
L
L
E
T
M
R
I
P
V
T
G
Y
E
F
E
E
F
I
H
G
I
Y
N
A
I
N
S
D
S
T
I
F
I
L
--------
D
T
GK
E
P
R
V
T
K
------
M
I
D
-
V
----
L
----
S
G
W
T
E
N
V
-
F
A
I
G
R
D
V
T
-----
E
N
D
K
---
N
L
K
I
D
I
T
D
N
P
Y
Y
Q
T
F
N
F
I
V
P
I
Q
L
I
C
G
E
I
P
T
L
R
G
-------------------------
8
PsiBlast_PDB
62.49
22%
-81
- C1 -
1MOR
1
GLMS_ECOLI
A:
[38-357]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
-
E
A
L
A
---
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
6
PsiBlast_PDB
62.19
22%
-81
- C1 -
1MOS
6
GLMS_ECOLI
A:
[38-357]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
-
E
A
L
A
---
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
7
PsiBlast_PDB
62.11
22%
-80
- C1 -
1MOQ
7
GLMS_ECOLI
A:
[38-357]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
-
E
A
L
A
---
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
11
PsiBlast_PDB
61.91
22%
-86
- C1 -
2VF5
1
GLMS_ECOLI
X:
[278-597]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
----
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
ALA
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
NIEE
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
12
PsiBlast_PDB
61.33
22%
-81
- C1 -
3OOJ
6
GLMS_ECOLI
A:
[278-597]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
----
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
10
PsiBlast_PDB
60.67
22%
-79
- C1 -
2VF4
-
GLMS_ECOLI
X:
[278-597]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
----
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
ALA
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
NIEE
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
5
PsiBlast_PDB
60.44
22%
-80
- C1 -
1JXA
1
GLMS_ECOLI
A:
[278-597]
-------------------
L
S
E
L
G
---------
P
-------
N
A
D
-
E
L
L
S
K
V
E
H
-----
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
-
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
-
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
----
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
-----
D
N
M
H
---
I
I
E
M
P
-
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
--------------------
28
HHSearch
58.92
18%
-69
* C1 *
2ZJ3
1
GFPT1_HUMAN
A:
[15-369]
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
NFDDYTVNL
G
-------
G
L
K
-
D
H
I
K
E
I
Q
--
R
C
R
R
L
I
----------
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
-
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
-
E
-
R
G
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
-
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
-
D
D
E
I
Q
K
L
A
---
T
---
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
--------
I
M
--
R
D
H
T
Y
A
------
K
C
Q
-
N
----
A
L
Q
Q
V
V
A
R
Q
G
R
P
-
V
V
I
C
D
K
E
D
T
E
T
I
K
N
T
K
R
---
T
I
K
V
P
H
S
-
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
---------------
32
HHSearch
58.81
20%
-74
- C1 -
1MOQ
9
GLMS_ECOLI
A:
[8-362]
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
---------
S
HGQVDLS
E
L
G
P
N
A
D
E
L
L
S
--
K
V
E
H
I
Q
----------
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
-
E
-
L
G
Y
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
-
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
K
R
I
E
A
L
A
---
E
---
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
--------
A
P
--
N
N
E
L
L
E
------
K
L
K
-
S
----
N
I
E
E
V
R
A
R
G
G
Q
L
-
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
---
I
I
E
M
P
H
V
-
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
---------------
14
PsiBlast_PDB
57.81
22%
-78
- C1 -
2ZJ4
1
GFPT1_HUMAN
A:
[60-359]
-------------------------------------------------------
C
R
R
L
I
----------
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
-
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
-
R
Y
C
K
E
-
R
G
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
-----
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
---
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
RDHT
Y
A
K
C
--
Q
N
A
L
Q
Q
V
V
A
R
QG
R
P
V
-
V
----
I
C
D
K
E
D
-----
T
-
E
T
I
K
---------
N
T
K
R
---
T
I
K
V
P
H
S
V
D
C
L
Q
G
-
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
-------------------------
13
PsiBlast_PDB
57.72
22%
-80
- C1 -
2ZJ3
1
GFPT1_HUMAN
A:
[60-359]
-------------------------------------------------------
C
R
R
L
I
----------
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
-
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
-
R
Y
C
K
E
-
R
G
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
-----
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
---
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
RDHT
Y
A
K
C
--
Q
N
A
L
Q
Q
V
V
A
R
QG
R
P
V
-
V
----
I
C
D
K
E
D
-----
T
-
E
T
I
K
---------
N
T
K
R
---
T
I
K
V
P
H
S
V
D
C
L
Q
G
-
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
-------------------------
15
PsiBlast_PDB
57.60
22%
-82
- C1 -
2V4M
2
GFPT1_HUMAN
A:
[61-360]
-------------------------------------------------------
C
R
R
L
I
----------
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
-
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
-
R
Y
C
K
E
-
R
G
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
-----
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
---
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
RDHT
Y
A
K
C
--
Q
N
A
L
Q
Q
V
V
A
R
QG
R
P
V
-
V
----
I
C
D
K
E
D
-----
T
-
E
T
I
K
---------
N
T
K
R
---
T
I
K
V
P
H
S
V
D
C
L
Q
G
-
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
-------------------------
17
PsiBlast_PDB
56.46
18%
-83
- C1 -
2POC
4
GFA1_CANAL
A:
[39-351]
------------------------------------------------------
G
L
K
S
W
L
S
T
I
R
R
CR
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
L
D
R
R
-
S
P
V
F
R
D
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
-
G
A
L
--
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
-
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
N
---
S
---
S
L
N
D
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
-----------
L
P
I
I
A
F
--------
A
T
--
R
D
S
L
F
P
------
K
V
M
S
A
----
I
E
Q
V
T
A
R
D
G
R
P
I
-
V
I
C
N
E
G
D
A
II---
S
---V
H
T
T
L
E
V
P
E
T
V
D
C
L
Q
G
-
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
-------------------------
18
PsiBlast_PDB
56.03
18%
-83
- C1 -
2PUT
4
GFA1_CANAL
A:
[39-351]
------------------------------------------------------
G
L
K
S
W
L
S
T
I
R
R
CR
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
L
D
R
R
-
S
P
V
F
R
D
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
-
G
A
L
--
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
-
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
N
---
S
---
S
L
N
D
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
K
----------
L
P
I
I
A
F
--------
A
T
--
R
D
S
L
F
P
------
K
V
M
S
A
----
I
E
Q
V
T
A
R
D
G
R
P
I
-
V
I
C
N
E
G
D
A
II---
S
---V
H
T
T
L
E
V
P
E
T
V
D
C
L
Q
G
-
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
-------------------------