@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0037: (2016-03-11 )
LEKKKKFRLFDAVLMAVCVVLVVESAAPAAAIGSSQFFWWIALLILFFLPYGLVSAELGTTYDDEGGIYDWVKRAFGRKWGARVAWLYWINYPIWMASLAVLFVEVITQIFPVSFGTPVSILIQLIFVWIVVIVSCYPVSDSKWILNIAAFCKVAIMLCLGVLGIYFAITKGLANDFSGKALLPTFDLESLSFISVILFNFLGFEVVTTLASDMENPKKQIPQAIIYGGILIAFFYLLAAFGMGAAIPTSELSTSGGLIDSFIMLIGGVNPFVIIIGIMFMYTLVANLVSWALGVNYVAMYAAKNKDLPAVFGKTNPKNDMPTGTSILNGIVASVLIVAAPLIPNENIFWAFFALNVVALLGSYILMFPAFLKLRKLDPDRERPFKVPGGKILLYLMTFVPMILLIITLIFSAVPLNGSSAELNEKIPILIGTIVAVIVGEICIWLAGKRKDKGEIKNEND
Atome Classification :
(20 SA)
--------------------------------------------------------.....---....10.......-----.20---.----------..---....-.30---....---------------------------.....40.......-.50-----.......-.60..----------..-------....70......------..--80.-.-.....--..-------------------------90..-......100....-...110-.--..-.....120-..-.--------------....130.------------..--...-----.140.......150---...-.--..---.----160-----.......170----...-.----..-..--.180.-.---.----.-..-.-..190-.-------...-----.....-200.-----------------------........210.....------.------.220.......230.......240..---..---..---------------.250--------------.--.-.--...-..260----.....----...270---..--......280--........290-----.......300..---------....-.310.----......320.......330...-....340.----..--...-.350.......360...--------------...--.370.......380.......390..-.....400.......410...---....420.......430-....-....440.......450------.......460-------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------LEK
K
K
---
K
F
R
L
F
D
A
V
L
M
A
V
C
-----
V
V
L
---
V
----------VE---SAAP-AA----AIGS---------------------------
S
Q
F
F
W
W
I
A
L
L
I
L
F
F
-L
P
Y
-----
G
L
V
S
AEL-GTTYD----------DE-------G
G
I
Y
D
W
V
K
R
A
FG------
R
K
--W-G-
A
-
R
V
A
W
L
--
Y
W-------------------------IN
Y
P
-
I
W
M
A
S
L
A
V
L
F
V
E
V
-
I
T
Q
IF--P--VS-FG
T
P
V
S
I
L
-
I
Q
-
L
--------------
I
F
V
W
I
V
V
I
------------
V
S
--
C
YP-----VSDS
K
W
I
L
N
I
A
A
F
C
---
K
V
A
-
I
--
M
L
---
C
----
L
G
V
-----
L
G
I
Y
F
A
I
T
------
K
G
L
-A----ND-FS--G
K
--
A
-
L
---
L
----
P
-TF-D-
L
E
S
---
L
-------
S
F
I
-----
S
V
I
L
F
-
N
--
F
-----------------------
L
G
F
E
V
V
T
T
L
A
S
D
ME
N
P
------
K
------
K
QI
P
Q
A
I
I
Y
G
G
I
L
I
A
F
F
Y
L
L
A
A
FGMG---AA---IP---------------TSE---------------L--S-T--SG
G
-
L
I
D
S
-----
F
I
M
L
I----GGV
N
P
----
F
V
--
I
I
I
G
I
M
F
M
---
Y
T
L
V
A
N
L
V
S
W
A
-----
L
G
V
N
Y
V
A
M
Y
AAK---------NKDL-PAVFG----KTNPKNDMP
T
G
T
S
I
L
N
G
I
V
A
S
V
-
L
I
V
AAPLI----PN--E
N
I
-
F
W
A
F
F
A
L
N
V
V
A
L
L
G
S
Y
I
--------------
L
M
F
--
P
A
F
L
K
L
RKLDPDRERPFKVPG
G
K
I
L
L
-
Y
L
M
T
F
V
P
M
I
L
L
I
I
T
L
I
F
SAVP---LNGSSAELNEKI
P
I
L
I
--
G
T
I
V
-
A
V
I
V
G
E
I
C
I
W
LAGKRKD------KGEIKNEND--------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.22
25%
-162
- C3 -
4DJI
-
GADC_ECOLI
A:
[10-448]
-----------------------------------------------------------
A
K
---
Q
L
T
L
L
G
F
F
A
I
T
A
S
-----
M
V
M
---
A
----------
V
Y
---
E
Y
P
T
-
F
A
----
T
S
G
F
---------------------------
S
L
V
F
F
L
L
L
G
G
I
L
W
F
-
I
P
V
-----
G
L
C
A
A
E
M
-
A
T
V
D
G
W---------
E
E
-------
G
G
V
F
A
W
V
S
N
T
L
G
------
P
R
--
W
-
G
-
F
-
A
A
I
S
F
--
G
Y
-------------------------
L
Q
I
A
-
I
G
F
I
P
M
L
Y
F
V
L
G
A
-
L
S
Y
I
L
KW
P
--
A
L
-
N
E
D
P
I
T
K
T
-
I
A
A
L
--------------
I
I
L
W
A
L
A
L
------------
T
Q
--
F
G
G
-----
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
---
G
I
L
-
L
P
A
F
I
---
L
----
I
A
L
-----
A
A
I
Y
L
H
S
G
----------
A
----
I
E
-
M
D
--
S
K
--
T
-
F
---
F
----
P
-
D
F
-
S
K
V
G
T
---
L
-------
V
V
F
-----
V
A
F
I
L
-
S
--
Y
-----------------------
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
------
G
------
R
D
Y
P
L
A
M
L
L
--
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
---
I
A
M
V
-
I
P
---------------
G
N
E
---------------
I
--
N
-
L
--
S
A
G
-
V
M
Q
T
-----
F
T
V
L
M
----
S
H
V
A
P
EIEW
T
V
--
R
V
I
S
A
L
L
L
---
L
G
V
L
A
E
I
A
S
W
I
-----
V
G
P
S
R
-
G
M
Y
V
T
A
---------
Q
K
N
L
L
P
A
A
F
A
----
K
M
N
-
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
----
G
G
--
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
--------------
M
L
F
--
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
-
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
PDN
I
Q
G
D
S
T
D
M
-------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.51
25%
-167
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-468]
----------------------------------------------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
-----
M
V
M
---
A
----------
V
Y
---
E
Y
P
T
-
F
A
----
T
S
G
F
---------------------------
S
L
V
F
F
L
L
L
G
G
I
L
W
F
-
I
P
V
-----
G
L
C
A
A
E
M
-
A
T
V
D
G
W-------------------
G
V
F
A
W
V
S
N
T
L
G
------
P
R
--
W
-
G
-
F
-
A
A
I
S
F
--
G
Y
-------------------------
L
Q
I
A
-
I
G
F
I
P
M
L
Y
F
V
L
G
A
-
L
S
Y
I
L
KW
P
--
A
L
-
N
E
D
P
I
T
K
T
-
I
A
A
L
--------------
I
I
L
W
A
L
A
L
------------
T
Q
--
F
G
G
-----
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
---
G
I
L
-
L
P
A
F
I
---
L
----
I
A
L
-----
A
A
I
Y
L
H
----------------------------
T
-
F
---
F
----
P
-
D
F
-
S
K
V
G
T
---
L
-------
V
V
F
-----
V
A
F
I
L
-
S
--
Y
-----------------------
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
------
G
------
R
D
Y
P
L
A
M
L
L
--
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
---
I
A
MV-
I
P
---------------
G
N
E
---------------
I
--
N
-
L
--
S
A
G
-
V
M
Q
T
-----
F
T
V
L
M
----
S
H
V
A
P
EIEW
T
V
--
R
V
I
S
A
L
L
L
---
L
G
V
L
A
E
I
A
S
W
I
-----
V
G
P
S
R
-
G
M
Y
V
T
A
---------
Q
K
N
L
L
P
A
A
F
A
----
K
M
N
-
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
----
G
G
--
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
--------------
M
L
F
--
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
-
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
PDN
I
Q
G
D
S
T
D
M
-------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
90.59
20%
-147
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-501]
----------------------------------------------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
-----
M
V
M
---
A
----------
V
Y
---
E
Y
P
T
-
F
A
----
T
S
G
F
---------------------------
S
L
V
F
F
L
L
L
G
G
I
L
W
F
-
I
P
V
-----
G
L
C
A
A
E
M
-
A
T
V
D
G
-------------------
W
G
V
F
A
W
V
S
N
T
L
G
------
P
R
--
W
-
G
-
F
-
A
A
I
S
F
--
G
Y
-------------------------
L
Q
I
A
-
I
G
F
I
P
M
L
Y
F
V
L
G
A
-
L
S
Y
I
L
--
K
--------
W
P
A
L
N
-
E
D
-
P
--------------
I
T
K
T
I
A
A
L
------------
I
I
--
L
W
A
-----
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
---
I
A
K
-
V
--
G
F
---
F
----
A
G
I
-----
L
L
P
A
F
I
L
I
------
A
-
L
-
A
----
A
I
-
Y
L
--
H
T
--
F
-
F
---
P
----
D
-
F
S
-
K
-
V
G
T
---
L
-------
V
V
F
-----
V
A
F
I
L
-
S
--
Y
-----------------------
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
------
G
------
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
---
M
V
---
I
P
---------------
G
N
E
---------------
I
--
N
-
L
--
S
A
G
-
V
M
Q
T
-----
F
T
V
L
M
SHVA
P
E
I
E
W
----
T
V
--
R
V
I
S
A
L
L
L
---
L
G
V
L
A
E
I
A
S
W
I
-----
V
G
P
S
R
G
M
Y
V
T
A
Q
---------
K
N
L
L
-
P
A
A
F
A
----
K
M
N
-
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
-
A
L
I
I
L
T
N
T
----
G
G
G
N
N
M
S
-
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
--------------
M
L
F
--
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
-
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
---
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
--
V
V
S
F
-
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
------
H
P
R
A
R
S
P
----------------------------------------------------------------------------------------------------
16
HHSearch
87.09
22%
-145
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-384]
-----------------------------------------------------------
A
H
---
K
V
G
L
I
P
V
T
L
M
V
S
G
-----
A
I
M
---
G
----------
S
G
---
V
F
L
L
-
P
A
N
L
A
-
S
T
G
G
---------------------------
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
-
L
G
L
-----
S
M
V
Y
A
K
M
-
S
F
L
D
P
----------
S
P
-------
G
G
S
Y
A
Y
A
R
R
C
F
G
------
P
F
--
L
-
G
-
Y
-
Q
T
N
V
L
--
Y
W
-------------------------
L
A
C
W
-
I
G
N
I
A
M
V
V
I
G
V
G
Y
-
L
S
Y
F
F
--
P
--
I
L
-
K
D
P
W
V
L
T
I
-
T
C
-
V
--------------
V
V
L
W
I
F
V
L
------------
L
N
--
I
V
G
-----
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
---
A
L
I
-
P
--
I
V
G
--
I
----
A
V
------
F
G
W
F
W
-
F
R
------
G
E
T
Y
M
----
A
-----------------------------
A
I
---
Q
-------
S
T
L
-----
N
V
T
L
W
-
S
--
F
-----------------------
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
------
K
------
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
---
G
M
---
I
P
---------------
N
A
A
---------------
L
--
R
-
V
S-
A
S
P
-
F
G
D
A
-----
A
R
M
A
-----
L
G
-
D
T
----
A
G
--
A
I
V
S
F
C
A
A
---
A
G
C
L
G
S
L
G
G
W
T
-----
L
L
A
G
Q
T
A
K
A
A
A
D
---------
D
G
L
F
-
P
P
I
F
A
----
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
S
S
I
-
S
----
P
N
A-
T
K
E
-
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
--------------
Y
T
C
--
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.01
23%
-161
- C3 -
3NCY
-
ADIC_SALTY
A:
[36-406]
--------------------------------------------------------------------------------------------------------------
A
----
A
T
G
G
---------------------------
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
-
L
A
L
-----
S
M
V
Y
A
K
M
-
S
S
L
D
P
----------
S
P
-------
G
G
S
Y
A
Y
A
R
R
C
F
G
------
P
F
--
L
-
G
-
Y
-
Q
T
N
V
L
--
Y
W
-------------------------
L
A
C
W
-
I
G
N
I
A
M
V
V
I
G
V
G
Y
-
L
S
Y
F
F
--
P
--
I
L
-
K
D
P
L
V
L
T
L
-
T
C
-
V
--------------
A
V
L
W
I
F
V
L
------------
L
N
----------
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
---
T
V
L
-
A
--
L
V
PIV
G
----
I
A
V
-----
F
G
W
F
W
---------------------
F
K
--
G
E
----------------
W
-
N
-
V
S
G
---
M
N
T
F
G
A
I
Q
S
T
L
-----
N
V
T
L
W
-
S
--
F
-----------------------
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
------
K
------
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
---
G
M
---
I
P
---------------
N
A
A
---------------
L
--
R
-
V
--
S
A
S
P
F
G
D
A
-----
A
R
M
A
L
----
G
--
D
T
----
A
G
--
A
I
V
S
F
C
A
A
---
A
G
C
L
G
S
L
G
G
W
T
-----
L
L
A
G
Q
T
A
K
A
A
A
D
---------
D
G
L
F
-
P
P
I
F
A
----
R
------
T
P
V
A
G
L
L
I
V
G
V
L
M
T
I
-
F
Q
F
S
S
-
M
S
----
P
N
A-
A
K
E
-
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
--------------
Y
T
C
--
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
--------
L
Y
-
L
L
I
T
F
V
A
F
V
Y
C
I
W
A
V
I
G
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.21
23%
-148
- C3 -
3L1L
2
ADIC_ECO57
A:
[36-385]
--------------------------------------------------------------------------------------------------------------
A
----
S
T
G
G
---------------------------
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
-
L
G
L
-----
S
M
V
Y
A
K
M
-
S
F
L
D
P
----------
S
P
-------
G
G
S
Y
A
Y
A
R
R
C
F
G
------
P
F
--
L
-
G
-
Y
-
Q
T
N
V
L
--
Y
W
-------------------------
L
A
C
W
-
I
G
N
I
A
M
V
V
I
G
V
G
Y
-
L
S
Y
F
F
--
P
--
I
L
-
K
D
P
W
V
L
T
I
-
T
C
-
V
--------------
V
V
L
W
I
F
V
L
------------
L
N
----------
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
---
T
V
L
-
A
--
L
I
P
I
V
G
----
I
A
V
-----
F
G
W
F
W
---------------------
F
R
--
G
E
--
T
-
Y
---
M
----
A
-------------A
I
Q
----
S
T
L
-----
N
V
T
L
W
-
S
--
F
-----------------------
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
------
K
------
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
---
G
M
---
I
P
---------------
N
A
A
---------------
L
--
R
-
V
--
S
A
S
P
F
G
D
A
-----
A
R
M
A
L
----
G
--
D
T
----
A
G
--
A
I
V
S
F
C
A
A
---
A
G
C
L
G
S
L
G
G
W
T
-----
L
L
A
G
Q
T
A
K
A
A
A
D
---------
D
G
L
F
-
P
P
I
F
A
----
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
S
S
-
I
S
----
P
N
--
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
--------------
Y
T
C
--
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.32
23%
-147
- C3 -
3OB6
1
ADIC_ECOLI
A:
[36-385]
--------------------------------------------------------------------------------------------------------------
A
----
S
T
G
G
---------------------------
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
-
L
G
L
-----
S
M
V
Y
A
K
M
-
S
F
L
D
P
----------
S
P
-------
G
G
S
Y
A
Y
A
R
R
C
F
G
------
P
F
--
L
-
G
-
Y
-
Q
T
N
V
L
--
Y
W
-------------------------
L
A
C
W
-
I
G
A
I
A
M
V
V
I
G
V
G
Y
-
L
S
Y
F
F
--
P
--
I
L
-
K
D
P
L
V
L
T
I
-
T
C
-
V
--------------
V
V
L
W
I
F
V
L
------------
L
N
----------
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
---
T
V
L
-
A
--
L
I
P
I
V
G
----
I
A
V
-----
F
G
W
F
W
---------------------
F
R
--
G
E
--
T
-
Y
---
M
----
A
-
A
W
-
N
-
V
S
G
---
L
G
T
F
G
A
I
Q
S
T
L
-----
N
V
T
L
W
-
S
--
F
-----------------------
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
------
K
------
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
---
G
M
---
I
P
---------------
N
A
A
---------------
L
--
R
-
V
--
S
A
S
P
F
G
D
A
-----
A
R
M
A
L
----
G
--
D
T
----
A
G
--
A
I
V
S
F
C
A
A
---
A
G
C
L
G
S
L
G
G
W
T
-----
L
L
A
G
Q
T
A
K
A
A
A
D
---------
D
G
L
F
-
P
P
I
F
A
----
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
S
S
-
I
S
----
P
--------
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
--------------
Y
T
C
--
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
82.22
17%
-151
* C3 *
3GIA
7
Y609_METJA
A:
[3-435]
---------------------------------------------------------
L
K
N
K
---
K
L
S
L
W
E
A
V
S
M
A
V
G
-----
V
M
I
---
G
----------
A
S
IFS
I
F
G
V
-
G
A
----
K
I
A
G
---------------------------
R
N
L
P
E
T
F
I
L
S
G
I
Y
A
-
L
L
V
-----
A
Y
S
Y
T
K
L
-
G
A
K
I
V
----------
S
N
-------
A
G
P
I
A
F
I
H
K
A
I
G
D-----
N
I
--
I
-
T
-
G
-
A
L
S
I
L
--
L
W
-------------------------
M
S
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
-
F
L
P
L
I
--
N
--
A
P
-
I
N
T
F
N
I
A
I
-
T
E
-
I
--------------
G
I
V
A
F
F
T
A
------------
L
N
--
F
F
G
-----
S
K
A
V
G
R
A
E
F
F
I
V
L
V
---
K
L
L
-
I
--
L
G
---
L
----
F
I
F
-----
A
G
L
I
T
-----------
I
-
H
----
P
S
-
Y
V
--
I
P
--
D
-
L
---
A
----
P
-
S
A
-
V
-
S
G
M
---
I
-------
F
A
S
-----
A
I
F
F
L
-
S
--
Y
-----------------------
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
------
K
------
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
---
L
P
---------------
I
D
E
---------------
L
--
I
-
K
--
A
S
E
-
N
A
L
A
-----
V
A
A
K
P
----
F
L
G
N
L
----
G
F
--
L
L
I
S
I
G
A
L
---
F
S
I
S
S
A
M
N
A
T
I
-----
Y
G
G
A
N
V
A
Y
S
L
A
K
---------
D
G
E
L
-
P
E
F
F
E
----
R
K
V
W
F
K
S
-----
T
E
G
L
Y
I
T
S
A
L
-
G
V
L
F
A
L
L
F
----
N
-------
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
--------------
F
V
I
--
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
-
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
-----------------------
R
F
V
F
--
Y
G
I
I
-
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
------
K
R
T
F
S
N
N
M
Y
VKS-----------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.96
23%
-146
- C3 -
3LRC
-
ADIC_ECO57
A:
[36-385]
--------------------------------------------------------------------------------------------------------------
A
----
S
T
G
G
---------------------------
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
-
L
G
L
-----
S
M
V
Y
A
K
M
-
S
F
L
D
P
----------
S
P
-------
G
G
S
Y
A
Y
A
R
R
C
F
G
------
P
F
--
L
-
G
-
Y
-
Q
T
N
V
L
--
Y
W
-------------------------
L
A
C
W
-
I
G
N
I
A
M
V
V
I
G
V
G
Y
-
L
S
Y
F
F
--
P
--
I
L
-
K
D
P
L
V
L
T
I
-
T
C
-
V
--------------
V
V
L
W
I
F
V
L
------------
L
N
----------
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
---
T
V
L
-
A
--
L
I
P
I
V
G
----
I
A
V
-----
F
G
W
F
W
---------------------
F
R
--
G
E
--
T
-
Y
---
M
----
A
-
A
W
-
N
-
V
S
G
---
L
GTFG
A
I
Q
S
T
L
-----
N
V
T
L
W
-
S
--
F
-----------------------
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
------
K
------
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
---
G
M
---
I
P
---------------
N
---------------------------------------------------
T
----
A
G
--
A
I
V
S
F
C
A
A
---
A
G
C
L
G
S
L
G
G
W
T
-----
L
L
A
G
Q
T
A
K
A
A
A
D
---------
D
G
L
F
-
P
P
I
F
A
----
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
S
S
-
I
S
----
P
N
--
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
--------------
Y
T
C
--
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.11
23%
-147
- C3 -
3LRB
-
ADIC_ECO57
A:
[36-385]
--------------------------------------------------------------------------------------------------------------
A
----
S
T
G
G
---------------------------
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
-
L
G
L
-----
S
M
V
Y
A
K
M
-
S
F
L
D
P
----------
S
P
-------
G
G
S
Y
A
Y
A
R
R
C
F
G
------
P
F
--
L
-
G
-
Y
-
Q
T
N
V
L
--
Y
W
-------------------------
L
A
C
W
-
I
G
N
I
A
M
V
V
I
G
V
G
Y
-
L
S
Y
F
F
--
P
--
I
L
-
K
D
P
L
V
L
T
I
-
T
C
-
V
--------------
V
V
L
W
I
F
V
L
------------
L
N
----------
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
---
T
V
L
-
A
--
L
I
P
I
V
G
----
I
A
V
-----
F
G
W
F
W
---------------------
F
R
--
G
E
--
T
-
Y
---
M
----
A
-
A
W
-
N
-
V
S
G
---
L
GTFG
A
I
Q
S
T
L
-----
N
V
T
L
W
-
S
--
F
-----------------------
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
------
K
------
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
---
G
M
---
I
P
---------------
N
---------------------------------------------------
T
----
A
G
--
A
I
V
S
F
C
A
A
---
A
G
C
L
G
S
L
G
G
W
T
-----
L
L
A
G
Q
T
A
K
A
A
A
D
---------
D
G
L
F
-
P
P
I
F
A
----
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
S
S
-
I
S
----
P
N
--
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
--------------
Y
T
C
--
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.21
25%
-155
- C3 -
3GIA
5
Y609_METJA
A:
[4-314]
----------------------------------------------------------
K
N
K
---
K
L
S
L
W
E
A
V
S
M
A
V
G
-----
V
M
I
G
A
S
I
----------
F
S
---
I
F
G
V
-
G
A
----
K
I
A
G
---------------------------
R
N
L
P
E
T
F
I
L
S
G
I
Y
A
-
L
L
V
-----
A
Y
S
Y
T
K
L
-
G
A
K
I
V
----------
S
N
-------
A
G
P
I
A
F
I
H
K
A
I
G
------
D
N
I
I
T
-
G
-
A
--
L
S
I
L
--
L
W
-------------------------
M
S
Y
V
-
I
S
I
A
----
L
F
A
K
G
-
F
A
G
Y
F
--
L
--
P
L
-
I
N
A
P
I
N
T
F
N
I
A
-
I
--------------
T
E
I
G
I
V
A
F
------------
F
T
--
A
L
N
-----
F
F
G
S
K
A
V
G
R
A
E
F
F
I
---
V
L
V
-
K
--
L
L
---
I
----
L
G
L
-----
F
--
I
F
A
G
L
------
I
T
I
-
H
----
P
S
-
Y
V
--
I
P
--
D
-
L
---
A
----
P
-
S
--
A
-
V
S
G
---
M
-------
I
F
A
-----
S
A
I
F
F
L
S
--
Y
-----------------------
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
------
K
------
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
---
L
P
---------------
I
D
E
---------------
L
I
K
A
-
S
--
E
N
A
-
L
A
V
A
-----
A
K
P
F
L
----
G
N
L
G
F
----
L
L
--
I
S
I
G
A
L
F
S
---
I
S
S
A
M
N
A
T
I
Y
G
------
G
A
N
-
V
A
Y
S
L
A
K
---------
D
G
E
L
-
P
E
F
F
E
----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
79.95
18%
-144
- C3 -
3GIA
6
Y609_METJA
A:
[3-370]
---------------------------------------------------------
L
K
N
K
---
K
L
S
L
W
E
A
V
S
M
A
V
G
-----
V
M
I
---
G
----------
A
S
---
I
F
S
I
-
F
G
V
G
A
K
I
A
G
R
---------------------------
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
-
L
L
V
-----
A
Y
S
Y
T
K
L
-
G
A
K
I
V
----------
S
N
-------
A
G
P
I
A
F
I
H
K
A
I
G
------
D
N
--
I
I
T
-
G
-
A
L
S
I
L
--
L
W
-------------------------
M
S
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
-
F
L
P
L
I
--
N
--
A
P
-
I
N
T
F
N
I
A
I
-
T
E
-
I
--------------
G
I
V
A
F
F
T
A
------------
L
N
--
F
F
G
-----
S
K
A
V
G
R
A
E
F
F
I
V
L
V
---
K
L
L
-
I
--
L
G
L
--
F
----
I
F
------
A
G
L
I
T
I
--------
H
P
S
-------
Y
-
V
I
--
P
---
D
-
L
---
A
----
P
-
S
A
-
V
-
S
G
M
---
I
-------
F
A
S
-----
A
I
F
F
L
-
S
--
Y
-----------------------
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
------
K
------
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
---
L
P
---------------
I
D
E
---------------
L
--
I
-
K
A
S
E
N
A
-
L
A
V
A
-----
A
K
P
F
-----
L
G
-
N
L
----
G
F
--
L
L
I
S
I
G
A
L
---
F
S
I
S
S
A
M
N
A
T
I
-----
Y
G
G
A
N
V
A
Y
S
L
A
K
---------
D
G
E
L
-
P
E
F
F
E
----
R
K
V
-
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
G
V
L
-
F
A
L
L
F
N
--------------
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
--------------
F
V
I
--
L
S
H
Y
I
L
I
D
E
V
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.91
25%
-155
- C3 -
3GI8
-
Y609_METJA
C:
[4-314]
----------------------------------------------------------
K
N
K
---
K
L
S
L
W
E
A
V
S
M
A
V
G
-----
V
M
I
GAS
I
----------
F
S
---
I
F
G
V
-
G
A
----
K
I
A
G
---------------------------
R
N
L
P
E
T
F
I
L
S
G
I
Y
A
-
L
L
V
-----
A
Y
S
Y
T
K
L
-
G
A
K
I
V
----------
S
N
-------
A
G
P
I
A
F
I
H
K
A
I
G
------
D
N
II
T
-
G
-
A
--
L
S
I
L
--
L
W
-------------------------
M
S
Y
V
-
I
S
I
A
----
L
F
A
K
G
-
F
A
G
Y
F
--
L
--
P
L
-
I
N
A
P
I
N
T
F
N
I
A
-
I
--------------
T
E
I
G
I
V
A
F
------------
F
T
--
A
L
N
-----
F
F
G
S
K
A
V
G
R
A
E
F
F
I
---
V
L
V
-
A
--
L
L
---
I
----
L
G
L
-----
F
--
I
F
A
G
L
------
I
T
I
-
H
----
P
S
-
Y
V
--
I
P
--
D
-
L
---
A
----
P
-
S
--
A
-
V
S
G
---
M
-------
I
F
A
-----
S
A
I
F
F
L
S
--
Y
-----------------------
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
------
K
------
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
---
L
P
---------------
I
D
E
---------------
L
IK
A
-
S
--
E
N
A
-
L
A
V
A
-----
A
K
P
F
L
----
G
N
L
G
F
----
L
L
--
I
S
I
G
A
L
F
S
---
I
S
S
A
M
N
A
T
I
Y
G
------
G
A
N
-
V
A
Y
S
L
A
K
---------
D
G
E
L
-
P
E
F
F
E
----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.10
25%
-157
- C3 -
3GI9
-
Y609_METJA
C:
[4-314]
----------------------------------------------------------
K
N
K
---
K
L
S
L
W
E
A
V
S
M
A
V
G
-----
V
M
I
G
A
S
I
----------
F
S
---
I
F
G
V
-
G
A
----
K
I
A
G
---------------------------
R
N
L
P
E
T
F
I
L
S
G
I
Y
A
-
L
L
V
-----
A
Y
S
Y
T
K
L
-
G
A
K
I
V
----------
S
N
-------
A
G
P
I
A
F
I
H
K
A
I
G
------
D
N
I
I
T
-
G
-
A
--
L
S
I
L
--
L
W
-------------------------
M
S
Y
V
-
I
S
I
A
----
L
F
A
K
G
-
F
A
G
Y
F
--
L
--
P
L
-
I
-
A
P
I
N
T
F
N
I
A
-
I
--------------
T
E
I
G
I
V
A
F
------------
F
T
--
A
L
N
-----
F
F
G
S
K
A
V
G
R
A
E
F
F
I
---
V
L
V
-
K
--
L
L
---
I
----
L
G
L
-----
F
--
I
F
A
G
L
------
I
T
I
-
H
----
P
S
-
Y
V
--
I
P
--
D
-
L
---
A
----
P
-
S
--
A
-
V
S
G
---
M
-------
I
F
A
-----
S
A
I
F
F
L
S
--
Y
-----------------------
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
------
K
------
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
---
L
P
---------------
I
D
E
---------------
L
I
K
A
-
S
--
E
N
A
-
L
A
V
A
-----
A
K
P
F
L
----
G
N
L
G
F
----
L
L
--
I
S
I
G
A
L
F
S
---
I
S
S
A
M
N
A
T
I
Y
G
------
G
A
N
-
V
A
Y
S
L
A
K
---------
D
G
E
L
-
P
E
F
F
E
----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
63.95
15%
-151
- C3 -
4P0G
9
MLTF_PSEAE
A:
[7-435]
----------------------------------------------------APT
A
L
E
R
V
Q
---
K
E
G
--------
V
L
-----
R
V
I
---
T
----------
R
N
---
S
P
A
T
-
Y
F
----
Q
D
R
N
---------------------------
G
E
T
G
F
E
Y
E
L
A
K
R
F
A
-
E
R
L
-----
G
-
V
E
L
K
I
-
E
T
A
-
D
----------
N
L
-------
D
D
L
Y
A
Q
L
S
R
E
G
G
------
P
A
--
L
-
A
-
A
---
A
G
L
--
T
P
-------------------------
G
R
E
D
-
D
A
S
V
R
Y
S
H
T
Y
L
D
V
-
T
P
Q
I
I
--
Y
--
R
N
-
G
Q
Q
R
P
T
R
P
-
E
D
-
L
--------------
V
G
K
R
I
M
V
L
K
GS
S
H
A
E
Q
L
A
E
L
K
K
--
Q
Y
P
E
L
K
Y
E
E
S
D
A
V
E
V
V
D
L
L
R
M
V
D
V
G
D
I
D
-
L
--
T
L
---
V
D
S
N
E
L
A
M
-----
N
Q
V
Y
F
P
N
V
------
R
V
A
-
F
----
D
F
-
G
E
--
A
R
--
G
-
L
---
A
----
W
-
A
L
-
P
-
G
G
D
---
D
-------
D
S
L
-----
M
N
E
V
N
-
A
--
F
-----------------------
L
D
Q
A
K
K
E
G
L
L
Q
R
L
K
D
--------------
R
Y
Y
G
H
V
D
V
L
G
--
Y
V
G
A
Y
T
F
A
Q
H
L
Q
Q
R
---
L
P
---
R
Y
---------------
E
S
H
---------------
F
--
K
-
Q
--
S
G
K
-
Q
L
D
T
------------------
D
----
W
R
--
L
L
A
A
I
G
Y
Q
---
E
S
L
W
Q
P
G
A
T
S
K
-----
T
G
V
R
G
L
M
M
L
T
N
R
---------
T
A
Q
A
-
M
G
V
S
N
----
R
L
D
P
K
Q
S
I
Q
G
G
S
K
Y
F
V
Q
I
R
S
E
L
----
P
E
S
I
K
----
E
P
--
D
R
S
-
W
F
A
L
A
A
Y
N
I
---
G
G
A
H
L
--------------
E
D
A
--
R
K
M
A
E
K
E
G
L
N
P
N
K
-----------
W
L
-
D
V
K
K
M
L
P
R
L
A
Q
--
K
Q
W
Y
A
K
T
R
---
Y
G
Y
A
R
G
G
E
T
V
H
F
V
Q
N
V
--
R
R
Y
Y
-
D
I
L
T
-----
W
V
T
Q
P
Q
-------------------------------------------------------------------------------------------------------------------
23
Fugue
63.73
18%
-159
- C1 -
4OIF
13
?
A:
[2-686]
PKY
E
R
T
Y
TTQANFILHGGDYNPDQWLDR
P
D
I
L
Q
A
D
L
E
L
M
K
L
S
HTN
T
F
T
V
GVFAWSA
L
E
P
E
E
GVY
R
F
E
W
L
D
K
V
F
D
D
I
Y
R
I
GGR
V
I
L
---
A
----------
T
P
---
S
G
A
R
-
P
A
----
W
L
S
Q
K
Y
PEV
L
R
V
N
AAR
V
R
Q
L
H
GGRHNHCFTS
S
V
Y
R
E
K
T
Q
H
I
N
R
L
L
-
A
E
R
YGDHP
A
L
L
M
W
H
V
-
S
N
E
Y
G
----------
G
E
C
HC
N
L
C
Q
E
A
F
R
E
W
L
K
K
K
Y
N
------
H
D
--
L
-
D
-
A
L
N
A
A
W
W
TS
F
W
SHTYTDWSQIESPSPIGEHTI
H
G
L
N
L
D
W
K
-
R
F
V
T
D
Q
T
I
S
F
F
E
N
E
I
V
P
L
R
--
E
--
L
T
-
P
H
I
P
I
T
T
N
-
F
M
-
A
D
T
HDLIPFQGLD
Y
S
K
F
A
K
H
L
D
V
------------
I
S
W
D
A
Y
P
-----
A
W
H
N
D
W
E
S
T
A
D
L
A
M
---
K
V
G
-
F
--
I
N
---
D
----
L
Y
R
S
LKQQ
P
F
L
L
M
E
C
T
------
P
S
L
-
V
----
N
W
-
H
K
V-
N
K
--
A
-
K
---
R
----
P
G
M
H
-
F
-
L
S
S
---
M
-------
Q
M
I
A
H
GSD
S
I
L
Y
F
-
Q
--
W
RKSRGSFEKFHGAVVDHDNRTDS
R
V
F
Q
E
V
A
E
V
G
K
A
L
K
K
M
------
S
GIVG
T
N
R
P
A
E
V
A
I
L
Y
D
--
W
E
N
N
W
A
L
N
D
A
Q
G
F
A
---
A
E
TKR
Y
P
---------------
Q
T
L
---------------
V
--
Q
-
H
--
Y
R
P
-
F
W
E
R
DIPVD
V
I
T
K
E
----
H
D
F
S
R
----
Y
K
--
L
L
I
A
P
M
L
Y
L
V
S
E
E
T
I
A
R
L
K
E
F
V
A
N
G
G
T
L
V
M
T
Y
I
S
G
I
V
D
E
HDLAYLGGW
H
Q
D
L
-
R
E
M
F
G
MEPI
E
T
D
T
L
Y
P
R
D
R
N
S
V
H
Y
R
G
R
S
Y
E
L
-
K
D
Y
A
T
V
I
K
I
H
AA
T
V
--
E
G
V
-
Y
E
D
D
F
Y
A
D
T
P
A
V
T
S
N
Q
Y
GK
G
Q
A
Y
Y
I
GGRLE
D
Q
F
H
--
R
D
F
Y
Q
E
L
M
E
K
L
D
L
R
P
V
L
F
V
K
H
E
K
G
V
S
-
V
Q
A
R
Q
A
P
E
C
D
Y
V
F
I
M
N
F
T
E
------
E
K
Q
A
V
V
L
E
E
K
V
K
D
L
F
TG
E
E
I
V
G
E
I
M
L
D
K
Y
E
V
R
V
V
E
K
R
R
------------------------------------------------------------------------------------------------------------------
24
Fugue
49.44
15%
-107
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------------------------------------------------------------------------------------------------
S
F
K
C
-
A
L
----
T
K
T
G
---------------------------
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
-
I
I
G
-----
F
L
G
N
S
V
A
-
I
W
M
F
V
----------
F
H
-------
M
K
P
W
S
-----------------------------------------------------------------------------------
G
--
I
S
-
V
Y
M
F
N
L
A
L
-
A
D
-
F
--------------
L
Y
V
L
T
L
P
A
------------
L
I
--
F
Y
Y
-----
F
N
K
T
D
W
I
F
G
-
D
A
M
C
---
K
L
Q
R
F
--
I
F
---
H
----
V
N
L
-----
Y
G
S
I
L
F
L
T
------
C
I
S
-
A
----
H
R
-
Y
S
--
G
V
--
V
-
Y
PKS
L
----
G
-
R
L
-
K
-
K
K
N
---
A
-------
I
C
I
-----
S
V
L
V
W
-
L
--
I
-----------------------
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
------
V
------
R
K
N
K
T
I
T
C
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
---
T
T
---
V
A
---------------
M
---------------------------------------------------
F
----
C
V
--
P
L
V
L
I
L
G
C
---
Y
G
L
I
V
R
A
L
I
Y
K
-----
M
K
-
K
Y
T
C
T
V
C
G
Y
---------
I
Y
N
P
-
E
--------
D
G
D
P
D
N
G
V
N
P
G
T
D
F
K
D
I
V
C
P
L
C
-
G
V
G
K
D
Q
F
E
----
E
V
--
E
E
P
-
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
--------------
V
S
Y
--
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
--------------
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
---
V
T
R
G
L
A
S
L
N
S
C
V
---------------
N
P
I
L
Y
F
L
A
G
D
T
F
R
------
R
R
---------------------------------------------------------------------------------------------------------
27
Fugue
48.70
10%
-120
- C2 -
1E7P
1
FRDA_WOLSU
A:
[1-655]
-----------------------M
K
V
Q
Y
C
D
S
L
V
IGGG
L
A
G
L
R
A
A
V
A
T
Q
Q
K
GLS
T
I
V
L
S
L
I
P
---
V
K
R
S
H
S
A
A
A
Q
G
G
M
-----
Q
A
S
---
L
GNSKMSDGDN
E
D
---
L
H
F
M
-
D
T
----
V
K
G
S
---------------------------
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
-----
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
M
A
I
I
N
-------
A
Q
K
T
T
I
T
E
E
D
F
R
HG
L
I
H
S
R
D
--
F
-
G
G
T
-
K
K
W
R
T
--
C
Y
-------------------------
T
A
D
A
-
T
G
H
T
M
L
F
A
V
A
N
E
C
-
L
K
L
G
V
--
S
--
I
Q
-
D
R
K
E
A
I
A
L
-
I
H
-
Q
--------------
D
G
K
C
Y
G
A
V
------------
V
R
--
D
L
V
-----
T
G
D
------
I
I
A
Y
V
---
A
K
G
-
T
--
L
I
---
A
----
T
G
G
-----
Y
G
R
I
Y
K
N
T
TNAVVC
E
G
T
-
G
----
T
A
-
I
A
--
L
E
--
T
-
G
---
I
----
A
-
Q
L
G
N
-
M
E
A
---
V
-------
Q
F
H
-----
P
T
P
L
F
-
P
SG
I
-----------------------
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
DGHRFM
P
------
D
Y
E
P
E
K
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
---
K
G
---
V
Q
SPY
G
Q
H
L
W
L
D
ISILG
R
K
H
---------------
I
--
E
-
T
--
N
L
R
-
D
V
Q
E
-----
I
C
E
Y
F
----
A
G
I
D
P
----
A
E
KW
A
P
V
L
P
M
Q
H
---
Y
S
M
G
G
I
R
T
D
Y
R
-----
G
E
A
K
L
K
G
L
F
S
A
G
---------
E
A
A
C
-
W
D
M
H
G
-----
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
-
Y
F
A
E
H
C
A
N
----
T
Q
--
V
D
L
-
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
--------------
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
---
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
--
R
V
P
M
-
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
SRGAHN
R
E
D
Y
P
K
R
D
D
INWLNRTLASWPNPEQTL
P
T
L
E
Y
E
A
L
D
VNEMEIAPGYRGYGAKGNYIEN
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
GKD
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
AKYKARNERLGD
17
HHSearch
36.78
11%
-90
- C3 -
3DH4
3
?
A:
[53-355]
-----------------------------------------------------------
G
K
---
S
L
P
W
W
A
V
G
A
S
L
I
A
-----
A
N
I
---
S
----------
A
E
---
Q
F
I
G
-
M
S
G
S
G
Y
S
I
G
L
---------------------------
A
I
A
S
Y
E
W
M
S
A
I
T
-
L
-
I
I
V
-----
G
K
Y
F
L
P
I
-
F
I
E
K
-----------
G
I
-------
Y
T
I
P
E
F
V
E
K
R
F
N
------
K
K
--
L
-
K
-
T
-
I
L
A
V
F
--
W
I
-------------------------
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
-
L
E
T
I
L
--
G
-----
I
P
L
M
--
Y
S
-
I
L
-
G
--------------
L
A
L
F
A
L
V
Y
------------
S
I
-------------
V
V
W
T
D
V
I
Q
V
F
F
---
L
V
L
-
G
--
G
F
M
--
T
----
T
Y
------
M
A
V
S
F
-
I
G
------
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
HF
E
M
I
---
L
DQSN
P
-
Q
Y
M
N
L
P
G
I
AVL
I
-------
G
G
L
W
----
V
A
N
L
Y
-
Y
--
W
-----------------------
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-------------
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
---
T
S
---------------
D
P
Q
L
M
A
S
L
GDIAATNLPS
A
--
A
N
A
--
D
K
A
-
Y
P
W
L
-----
T
-
Q
F
-----
L
P
-
V
G
----
V
K
--
G
V
V
F
A
A
L
A
---
A
A
I
V
S
S
L
A
S
M
L
-----
N
S
T
A
T
I
F
T
---
M
---------
D
I
Y
K
-
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
32.30
12%
-100
- C3 -
2JLN
2
?
A:
[22-180]
---------------------------------------------------------
Y
A
E
R
---
S
V
G
P
F
S
L
A
A
I
W
F
A
-----
M
A
I
---
Q
----------
V
A
---
I
F
I
A
A
G
Q
M
T
S
S
F
Q
V
W
---------------------------
Q
V
I
V
A
I
A
A
G
C
T
I
-
A
-
V
I
L
-----
L
F
F
T
Q
S
A
-
A
I
R
W
G
-------------------
I
N
F
T
V
A
A
R
M
P
F
G
------
I
R
--
G
-
S
-
L
-
I
P
I
T
L
--
K
A
-------------------------
L
L
S
L
-
F
W
F
G
F
Q
T
W
L
G
A
L
A
-
L
D
E
I
T
--
R
L
L
T
G
F
T
N
L
---
P
L
-
W
I
-
V
--------------
I
F
G
A
I
Q
V
V
------------
T
T
--
F
Y
G
-----
I
T
F
I
R
W
M
N
V
F
A
S
P
V
---
L
L
A
-
M
--
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------