@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0043: (2016-03-11 )
MKMEQALNITSEIGKLQTVLVKRPGSELENITPEYLESLLFDDIPYLKMMQKEHDFFAKTMRDSNIEVLYLEKLAAEALREANNKESFLTKMIKESNQMDESALYVRDYLMSFDEEEMIRKLMSGLKKSEIPERKKKHLNEMMDEQYPFFLDPLPNLYFTRDPAAVIGNGVTINRMFQPARRRESIFIELILKHHPRFSNQDIPVWSGRGEPFSLEGGDELVLNEETVLVGVSERTDARAVERLAESLFNRSPKIKRVLAVEIPETRSFMHLDTVFTMVNFAQFTIHPAIQNQQGELNIYILEKSENGLEITPRRDFQRVIAEVLDEPEIDFIPCGGEDVIVSAREQWNDGANTLAIAPGEVITYDRNQVSNDLLRSAGIKVHEVISSELSRGRGGPRCMTMPLVRENLK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.......--.80.--..--.....90......-..--100....--.....110.-.-.....120.......130.--......----140...---....150.......160.......170.......180.......190.......200.....----..210---........220.......230.......240......-.-250...-.....260.......270.......280.......290.......300-------......---.310..------..-.---...320.......330......-----.--340.........350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
M
E
Q
A
L
N
I
T
S
E
I
G
K
L
Q
T
V
L
V
KRPG
S
E
L
ENI
T
P
E
Y
L
E
S
L
LFDD
I
P
Y
L
K
M
M
Q
K
E
H
D
F
F
A
K
T
MRDSN
I
E
V
L
Y
L
E
K
L
A
A
E
A
--
L
R
EA--N
N
--
K
E
S
F
L
T
K
M
I
K
E
SN-QM--
D
--
E
S
A
L
--
Y
V
R
D
Y
L
MSF-
D
-
E
E
E
M
I
R
K
L
M
S
G
L
K
KSE
I
P
E
--
R
K
K
K
H
L
----
N
E
M
M
D
E---QY
P
F
FLDPLPN
L
Y
FTRD
P
A
A
VIGNG
V
T
I
N
R
MFQ
P
A
R
R
R
E
S
I
F
I
E
L
I
L
K
HHPRFSNQDIPVWS----GRGE----
P
F
SLEGG
D
E
L
V
LNE
E
T
V
L
V
G
VSERT
D
A
R
A
V
E
R
L
A
E
S
L
-
F
-NR-SPK-
I
K
R
V
L
A
V
EIPETR
S
F
M
H
L
D
T
V
F
T
M
V
N
F
A
Q
F
T
I
HPAIQNQQG
E
L
N
I
Y
I
L
-------EKSENG---
L
E
-IT
P
------
R
R
-
D
---
F
Q
R
V
I
A
E
V
LDEPE
I
D
F
IPCGGE-----
D
--
V
--
I
V
S
A
R
E
QWNDGA
N
T
L
A
IAPG
E
V
I
T
YD
R
N
Q
V
S
N
D
L
L
R
S
AGI
K
V
H
E
V
I
S
S
E
L
SRGRGG
P
R
C
M
T
M
P
L
V
R
ENLK
1
PsiBlast_PDB
98.26
46%
-89
- C6 -
4BOF
4
ARCA_STRPY
A:
[4-411]
---
Q
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
T
P
--
E
I
--
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
--
R
--
A
T
K
K
--
A
I
R
E
L
L
M
A
I
E
D
-
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
IP
A
S
E
K
G
L
----
T
D
L
V
E
S
---
N
Y
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
----
D
R
N
E
----
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
-
F
-
K
Q
-
N
L
G
-
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
---
E
G
D
L
R
V
Y
S
V
-------
T
Y
D
N
E
E
---
L
H
-
I
V
E
------
E
K
G
D
---
L
A
E
L
L
A
A
N
L
G
V
E
K
V
D
L
I
R
C
G
G
D
-----
N
--
L
--
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
22
PsiBlast_CBE
98.24
46%
-88
- C6 -
4BOF
4
ARCA_STRPY
G:
[4-411]
---
Q
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
T
P
--
E
I
--
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
--
R
--
A
T
K
K
--
A
I
R
E
L
L
M
A
I
E
D
-
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
IP
A
S
E
K
G
L
----
T
D
L
V
E
S
---
N
Y
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
----
D
R
N
E
----
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
-
F
-
K
Q
-
N
L
G
-
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
---
E
G
D
L
R
V
Y
S
V
-------
T
Y
D
N
E
E
---
L
H
-
I
V
E
------
E
K
G
D
---
L
A
E
L
L
A
A
N
L
G
V
E
K
V
D
L
I
R
C
G
G
D
-----
N
--
L
--
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
21
PsiBlast_CBE
98.16
46%
-88
- C6 -
4BOF
3
ARCA_STRPY
H:
[4-411]
---
Q
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
T
P
--
E
I
--
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
--
R
--
A
T
K
K
--
A
I
R
E
L
L
M
A
I
E
D
-
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
IP
A
S
E
K
G
L
----
T
D
L
V
E
S
---
N
Y
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
----
D
R
N
E
----
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
-
F
-
K
Q
-
N
L
G
-
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
---
E
G
D
L
R
V
Y
S
V
-------
T
Y
D
N
E
E
---
L
H
-
I
V
E
------
E
K
G
D
---
L
A
E
L
L
A
A
N
L
G
V
E
K
V
D
L
I
R
C
G
G
D
-----
N
--
L
--
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
27
PsiBlast_CBE
98.08
46%
-88
- C6 -
4BOF
3
ARCA_STRPY
B:
[1-411]
M
T
A
Q
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
T
P
--
E
I
--
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
--
R
--
A
T
K
K
--
A
I
R
E
L
L
M
A
I
E
D
-
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
IP
A
S
E
K
G
L
----
T
D
L
V
E
S
---
N
Y
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
----
D
R
N
E
----
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
-
F
-
K
Q
-
N
L
G
-
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
---
E
G
D
L
R
V
Y
S
V
-------
T
Y
D
N
E
E
---
L
H
-
I
V
E
------
E
K
G
D
---
L
A
E
L
L
A
A
N
L
G
V
E
K
V
D
L
I
R
C
G
G
D
-----
N
--
L
--
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
24
PsiBlast_CBE
97.99
46%
-88
- C6 -
4BOF
2
ARCA_STRPY
E:
[6-411]
-----
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
T
P
--
E
I
--
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
--
R
--
A
T
K
K
--
A
I
R
E
L
L
M
A
I
E
D
-
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
IP
A
S
E
K
G
L
----
T
D
L
V
E
S
---
N
Y
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
----
D
R
N
E
----
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
-
F
-
K
Q
-
N
L
G
-
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
---
E
G
D
L
R
V
Y
S
V
-------
T
Y
D
N
E
E
---
L
H
-
I
V
E
------
E
K
G
D
---
L
A
E
L
L
A
A
N
L
G
V
E
K
V
D
L
I
R
C
G
G
D
-----
N
--
L
--
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
23
PsiBlast_CBE
97.92
46%
-87
- C6 -
4BOF
5
ARCA_STRPY
F:
[3-411]
--
A
Q
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
T
P
--
E
I
--
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
--
R
--
A
T
K
K
--
A
I
R
E
L
L
M
A
I
E
D
-
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
IP
A
S
E
K
G
L
----
T
D
L
V
E
S
---
N
Y
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
----
D
R
N
E
----
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
-
F
-
K
Q
-
N
L
G
-
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
---
E
G
D
L
R
V
Y
S
V
-------
T
Y
D
N
E
E
---
L
H
-
I
V
E
------
E
K
G
D
---
L
A
E
L
L
A
A
N
L
G
V
E
K
V
D
L
I
R
C
G
G
D
-----
N
--
L
--
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
25
PsiBlast_CBE
96.88
46%
-85
- C6 -
4BOF
2
ARCA_STRPY
D:
[3-411]
--
A
Q
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
T
P
--
E
I
--
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
--
R
--
A
T
K
K
--
A
I
R
E
L
L
M
A
I
E
D
-
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
IP
A
S
E
K
G
L
----
T
D
L
V
E
S
---
N
Y
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
----
D
R
N
E
----
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
-
F
-
K
Q
-
N
L
G
-
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
---
E
G
D
L
R
V
Y
S
V
-------
T
Y
D
N
E
E
---
L
H
-
I
V
E
------
E
K
G
D
---
L
A
E
L
L
A
A
N
L
G
V
E
K
V
D
L
I
R
C
G
G
D
-----
N
--
L
--
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
26
PsiBlast_CBE
96.79
46%
-84
- C6 -
4BOF
3
ARCA_STRPY
C:
[3-411]
--
A
Q
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
T
P
--
E
I
--
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
--
R
--
A
T
K
K
--
A
I
R
E
L
L
M
A
I
E
D
-
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
IP
A
S
E
K
G
L
----
T
D
L
V
E
S
---
N
Y
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
----
D
R
N
E
----
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
-
F
-
K
Q
-
N
L
G
-
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
---
E
G
D
L
R
V
Y
S
V
-------
T
Y
D
N
E
E
---
L
H
-
I
V
E
------
E
K
G
D
---
L
A
E
L
L
A
A
N
L
G
V
E
K
V
D
L
I
R
C
G
G
D
-----
N
--
L
--
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
45
HHSearch
90.28
35%
-82
- C6 -
1S9R
7
ARCA_MYCAR
A:
[7-409]
--
K
F
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
--
Y
D
L
A
S
Q
E
A
--
K
D
K
L
I
E
E
F
L
E
D
S
E
-
P
V
--
L
S
E
E
H
K
V
--
V
V
R
N
F
L
K
A
K
K
T
-
S
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
G
I
--
E
--------------
A
---
D
H
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
--
T
P
W
Y
Y
----
D
P
S
L
----
K
L
S
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
-
V
-
A
N
K
E
C
E
-
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
I
A
N
---
D
V
F
K
F
W
D
Y
-------
D
L
V
N
G
G
AE-
P
Q
P
V
E
N
------
G
L
-
P
---
L
E
G
L
L
Q
S
I
I
N
-
K
K
P
V
L
I
P
I
A
G
E
-----
G
AS
Q
--
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
42
PsiBlast_CBE
89.61
34%
-80
- C6 -
1S9R
7
ARCA_MYCAR
B:
[9-409]
----
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
--
Y
D
L
A
--
S
Q
EA
K
D
K
L
I
E
E
F
L
E
D
S
E
-
P
V
LS
E
--
E
H
K
V
--
V
V
R
N
F
L
K
A
K
-
K
T
S
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
G
----------------
I
E
A
---
D
H
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
--
P
W
Y
Y
----
D
P
S
L
----
K
L
S
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
-
V
A
N
K
-
E
C
E
-
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
-
I
A
N
D
V
F
K
F
W
D
Y
D
L
VNGGAEP
Q
P
V
E
N
G
---
L
P
-
L
----------------
E
G
L
L
Q
S
I
I
N
K
K
P
V
-
L
I
P
I
A
G
E
-----
G
--
A
SQ
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
8
PsiBlast_PDB
89.10
34%
-81
- C6 -
1LXY
3
ARCA_MYCAR
A:
[8-408]
----
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
--
Y
D
L
A
--
S
Q
E
A
K
D
K
L
I
E
E
F
L
E
D
S
E
-
P
V
LS
E
--
E
H
K
V
--
V
V
R
N
F
L
K
A
K
-
K
T
S
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
G
----------------
I
E
A
---
D
H
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
--
P
W
Y
Y
----
D
P
S
L
----
K
L
S
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
-
V
A
N
K
-
E
C
E
-
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
-
I
A
N
D
V
F
K
F
W
D
Y
D
L
VNGGAEP
Q
P
V
E
N
G
---
L
P
-
L
----------------
E
G
L
L
Q
S
I
I
N
K
K
P
V
-
L
I
P
I
A
G
E
-----
G
--
A
S
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
7
PsiBlast_PDB
88.59
34%
-80
- C6 -
1S9R
7
ARCA_MYCAR
A:
[9-409]
----
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
--
Y
D
L
A
--
S
Q
E
A
K
D
K
L
I
E
E
F
L
E
D
S
E
-
P
V
LS
E
--
E
H
K
V
--
V
V
R
N
F
L
K
A
K
-
K
T
S
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
G
----------------
I
E
A
---
D
H
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
--
P
W
Y
Y
----
D
P
S
L
----
K
L
S
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
-
V
A
N
K
-
E
C
E
-
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
-
I
A
N
D
V
F
K
F
W
D
Y
D
L
VNGGAEP
Q
P
V
E
N
G
---
L
P
-
L
----------------
E
G
L
L
Q
S
I
I
N
K
K
P
V
-
L
I
P
I
A
G
E
-----
G
--
A
S
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
43
PsiBlast_CBE
88.28
34%
-81
- C6 -
1LXY
3
ARCA_MYCAR
B:
[8-408]
----
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
--
Y
D
L
A
--
S
Q
EA
K
D
K
L
I
E
E
F
L
E
D
S
E
-
P
V
LS
E
--
E
H
K
V
--
V
V
R
N
F
L
K
A
K
-
K
T
S
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
G
----------------
I
E
A
---
D
H
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
--
P
W
Y
Y
----
D
P
S
L
----
K
L
S
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
-
V
A
N
K
-
E
C
E
-
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
-
I
A
N
D
V
F
K
F
W
D
Y
D
L
VNGGAEP
Q
P
V
E
N
G
---
L
P
-
L
----------------
E
G
L
L
Q
S
I
I
N
K
K
P
V
-
L
I
P
I
A
G
E
-----
G
--
A
SQ
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
44
HHSearch
87.84
33%
-86
- C6 -
2A9G
1
ARCA_PSEAE
A:
[6-416]
----
T
K
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
N
P
--
E
A
--
L
K
W
I
L
D
R
K
I
T
A
D
S
-
V
G
--
L
--
G
L
T
S
--
E
L
R
S
W
L
E
S
L
-
E
-
P
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
A
--
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
-
G
---
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
GDPD
K
D
H
G
----
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
-
F
-
A
K
---
G
A
A
E
R
V
I
V
A
G
L
P
K
S
R
A
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
---
K
E
I
V
P
F
S
L
-------
R
P
D
P
S
S
PYG
M
N
I
R
R
E
------
E
K
-
T
---
F
L
E
V
V
A
E
S
L
G
L
K
K
L
R
V
V
E
T
G
-----------------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
-
6
PsiBlast_PDB
86.09
33%
-77
- C6 -
2AAF
-
ARCA_PSEAE
A:
[8-414]
------
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
N
P
--
E
A
--
L
K
W
I
L
D
R
K
I
T
A
D
S
-
V
G
--
L
--
G
L
T
S
--
E
L
R
S
W
L
E
S
L
-
E
-
P
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
A
--
S
E
G
A
N
I
----
L
K
M
Y
R
E
Y
LG
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
----
G
D
P
D
KDHG
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
-
F
-
A
K
-
G
A
A
--
E
R
V
I
V
A
G
L
P
K
S
R
A
A
M
A
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
I
V
P
F
S
L
R
P
D
-------
P
S
S
P
Y
G
---
M
N
-
I
--------
R
R
-
E
EKT
F
L
E
V
V
A
E
S
L
G
L
K
K
L
R
V
V
E
T
G
-----------------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
-
M
T
C
P
I
V
R
D
---
32
PsiBlast_CBE
85.96
35%
-80
- C6 -
4E4J
2
?
K:
[35-432]
-----
G
I
N
V
Y
S
E
I
G
E
L
K
E
V
L
V
H
T
P
G
D
E
I
R
Y
T
A
P
S
R
L
E
E
L
L
F
S
A
V
L
K
A
D
T
A
I
E
E
H
K
G
F
V
K
I
L
Q
N
N
G
I
K
V
I
Q
L
C
D
L
V
A
E
T
YE
L
C
S
K
--
E
V
--
R
N
S
F
I
E
Q
Y
L
D
E
A
L
-
P
V
--
L
--
K
K
E
I
RP
V
V
K
D
Y
L
L
S
F
-
P
-
T
V
Q
M
V
R
K
M
M
S
G
I
L
A
N
E
----------
L
----
N
I
K
Q
D
N
-----
P
L
I
I
D
G
M
P
N
L
Y
F
T
R
D
P
F
A
S
M
G
N
G
V
S
I
N
C
M
K
Y
P
T
R
K
R
E
V
I
F
S
R
F
V
F
T
N
N
P
K
Y
K
N
T
P
-
R
Y
F
D
----
I
V
G
N
----
N
G
T
I
E
G
G
D
I
F
I
Y
N
S
K
T
L
V
I
G
N
S
E
R
T
N
F
A
A
I
E
S
V
A
K
N
I
Q
A
-
N
K
-
D
C
T
-
F
E
R
I
V
V
I
N
V
P
P
M
P
N
L
M
H
L
D
T
W
L
T
M
L
D
Y
D
K
F
L
Y
S
P
N
M
M
N
--------
V
L
-------
K
I
W
E
I
D
---
L
N
-
V
K
P
VKFVEK
K
G
-
T
---
L
E
E
V
L
Y
S
I
I
D
K
K
P
I
-
L
I
P
I
A
G
K
GANQL
D
--
I
--
D
I
---
E
T
H
F
D
G
T
N
Y
L
T
I
A
P
G
V
V
V
G
Y
E
R
N
E
K
T
Q
K
A
L
V
E
A
G
I
K
V
L
S
F
N
G
S
Q
L
S
L
G
M
G
S
A
R
C
M
S
M
P
L
I
R
E
N
L
K
39
PsiBlast_CBE
85.87
35%
-81
- C6 -
4E4J
2
?
D:
[35-432]
-----
G
I
N
V
Y
S
E
I
G
E
L
K
E
V
L
V
H
T
P
G
D
E
I
R
Y
T
A
P
S
R
L
E
E
L
L
F
S
A
V
L
K
A
D
T
A
I
E
E
H
K
G
F
V
K
I
L
Q
N
N
G
I
K
V
I
Q
L
C
D
L
V
A
E
T
YE
L
C
S
K
--
E
V
--
R
N
S
F
I
E
Q
Y
L
D
E
A
L
-
P
V
--
L
--
K
K
E
I
RP
V
V
K
D
Y
L
L
S
F
-
P
-
T
V
Q
M
V
R
K
M
M
S
G
I
L
A
N
E
----------
L
----
N
I
K
Q
D
N
-----
P
L
I
I
D
G
M
P
N
L
Y
F
T
R
D
P
F
A
S
M
G
N
G
V
S
I
N
C
M
K
Y
P
T
R
K
R
E
V
I
F
S
R
F
V
F
T
N
N
P
K
Y
K
N
T
P
-
R
Y
F
D
----
I
V
G
N
----
N
G
T
I
E
G
G
D
I
F
I
Y
N
S
K
T
L
V
I
G
N
S
E
R
T
N
F
A
A
I
E
S
V
A
K
N
I
Q
A
-
N
K
-
D
C
T
-
F
E
R
I
V
V
I
N
V
P
P
M
P
N
L
M
H
L
D
T
W
L
T
M
L
D
Y
D
K
F
L
Y
S
P
N
M
M
N
--------
V
L
-------
K
I
W
E
I
D
---
L
N
-
V
K
P
VKFVEK
K
G
-
T
---
L
E
E
V
L
Y
S
I
I
D
K
K
P
I
-
L
I
P
I
A
G
K
GANQL
D
--
I
--
D
I
---
E
T
H
F
D
G
T
N
Y
L
T
I
A
P
G
V
V
V
G
Y
E
R
N
E
K
T
Q
K
A
L
V
E
A
G
I
K
V
L
S
F
N
G
S
Q
L
S
L
G
M
G
S
A
R
C
M
S
M
P
L
I
R
E
N
L
K
36
PsiBlast_CBE
85.81
35%
-80
- C6 -
4E4J
2
?
G:
[35-432]
-----
G
I
N
V
Y
S
E
I
G
E
L
K
E
V
L
V
H
T
P
G
D
E
I
R
Y
T
A
P
S
R
L
E
E
L
L
F
S
A
V
L
K
A
D
T
A
I
E
E
H
K
G
F
V
K
I
L
Q
N
N
G
I
K
V
I
Q
L
C
D
L
V
A
E
T
YE
L
C
S
K
--
E
V
--
R
N
S
F
I
E
Q
Y
L
D
E
A
L
-
P
V
--
L
--
K
K
E
I
RP
V
V
K
D
Y
L
L
S
F
-
P
-
T
V
Q
M
V
R
K
M
M
S
G
I
L
A
N
E
----------
L
----
N
I
K
Q
D
N
-----
P
L
I
I
D
G
M
P
N
L
Y
F
T
R
D
P
F
A
S
M
G
N
G
V
S
I
N
C
M
K
Y
P
T
R
K
R
E
V
I
F
S
R
F
V
F
T
N
N
P
K
Y
K
N
T
P
-
R
Y
F
D
----
I
V
G
N
----
N
G
T
I
E
G
G
D
I
F
I
Y
N
S
K
T
L
V
I
G
N
S
E
R
T
N
F
A
A
I
E
S
V
A
K
N
I
Q
A
-
N
K
-
D
C
T
-
F
E
R
I
V
V
I
N
V
P
P
M
P
N
L
M
H
L
D
T
W
L
T
M
L
D
Y
D
K
F
L
Y
S
P
N
M
M
N
--------
V
L
-------
K
I
W
E
I
D
---
L
N
-
V
K
P
VKFVEK
K
G
-
T
---
L
E
E
V
L
Y
S
I
I
D
K
K
P
I
-
L
I
P
I
A
G
K
GANQL
D
--
I
--
D
I
---
E
T
H
F
D
G
T
N
Y
L
T
I
A
P
G
V
V
V
G
Y
E
R
N
E
K
T
Q
K
A
L
V
E
A
G
I
K
V
L
S
F
N
G
S
Q
L
S
L
G
M
G
S
A
R
C
M
S
M
P
L
I
R
E
N
L
K
31
PsiBlast_CBE
85.76
35%
-80
- C6 -
4E4J
2
?
L:
[35-432]
-----
G
I
N
V
Y
S
E
I
G
E
L
K
E
V
L
V
H
T
P
G
D
E
I
R
Y
T
A
P
S
R
L
E
E
L
L
F
S
A
V
L
K
A
D
T
A
I
E
E
H
K
G
F
V
K
I
L
Q
N
N
G
I
K
V
I
Q
L
C
D
L
V
A
E
T
YE
L
C
S
K
--
E
V
--
R
N
S
F
I
E
Q
Y
L
D
E
A
L
-
P
V
--
L
--
K
K
E
I
RP
V
V
K
D
Y
L
L
S
F
-
P
-
T
V
Q
M
V
R
K
M
M
S
G
I
L
A
N
E
----------
L
----
N
I
K
Q
D
N
-----
P
L
I
I
D
G
M
P
N
L
Y
F
T
R
D
P
F
A
S
M
G
N
G
V
S
I
N
C
M
K
Y
P
T
R
K
R
E
V
I
F
S
R
F
V
F
T
N
N
P
K
Y
K
N
T
P
-
R
Y
F
D
----
I
V
G
N
----
N
G
T
I
E
G
G
D
I
F
I
Y
N
S
K
T
L
V
I
G
N
S
E
R
T
N
F
A
A
I
E
S
V
A
K
N
I
Q
A
-
N
K
-
D
C
T
-
F
E
R
I
V
V
I
N
V
P
P
M
P
N
L
M
H
L
D
T
W
L
T
M
L
D
Y
D
K
F
L
Y
S
P
N
M
M
N
--------
V
L
-------
K
I
W
E
I
D
---
L
N
-
V
K
P
VKFVEK
K
G
-
T
---
L
E
E
V
L
Y
S
I
I
D
K
K
P
I
-
L
I
P
I
A
G
K
GANQL
D
--
I
--
D
I
---
E
T
H
F
D
G
T
N
Y
L
T
I
A
P
G
V
V
V
G
Y
E
R
N
E
K
T
Q
K
A
L
V
E
A
G
I
K
V
L
S
F
N
G
S
Q
L
S
L
G
M
G
S
A
R
C
M
S
M
P
L
I
R
E
N
L
K
33
PsiBlast_CBE
85.75
35%
-82
- C6 -
4E4J
2
?
J:
[35-432]
-----
G
I
N
V
Y
S
E
I
G
E
L
K
E
V
L
V
H
T
P
G
D
E
I
R
Y
T
A
P
S
R
L
E
E
L
L
F
S
A
V
L
K
A
D
T
A
I
E
E
H
K
G
F
V
K
I
L
Q
N
N
G
I
K
V
I
Q
L
C
D
L
V
A
E
T
YE
L
C
S
K
--
E
V
--
R
N
S
F
I
E
Q
Y
L
D
E
A
L
-
P
V
--
L
--
K
K
E
I
RP
V
V
K
D
Y
L
L
S
F
-
P
-
T
V
Q
M
V
R
K
M
M
S
G
I
L
A
N
E
----------
L
----
N
I
K
Q
D
N
-----
P
L
I
I
D
G
M
P
N
L
Y
F
T
R
D
P
F
A
S
M
G
N
G
V
S
I
N
C
M
K
Y
P
T
R
K
R
E
V
I
F
S
R
F
V
F
T
N
N
P
K
Y
K
N
T
P
-
R
Y
F
D
----
I
V
G
N
----
N
G
T
I
E
G
G
D
I
F
I
Y
N
S
K
T
L
V
I
G
N
S
E
R
T
N
F
A
A
I
E
S
V
A
K
N
I
Q
A
-
N
K
-
D
C
T
-
F
E
R
I
V
V
I
N
V
P
P
M
P
N
L
M
H
L
D
T
W
L
T
M
L
D
Y
D
K
F
L
Y
S
P
N
M
M
N
--------
V
L
-------
K
I
W
E
I
D
---
L
N
-
V
K
P
VKFVEK
K
G
-
T
---
L
E
E
V
L
Y
S
I
I
D
K
K
P
I
-
L
I
P
I
A
G
K
GANQL
D
--
I
--
D
I
---
E
T
H
F
D
G
T
N
Y
L
T
I
A
P
G
V
V
V
G
Y
E
R
N
E
K
T
Q
K
A
L
V
E
A
G
I
K
V
L
S
F
N
G
S
Q
L
S
L
G
M
G
S
A
R
C
M
S
M
P
L
I
R
E
N
L
K