@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0078: (2016-03-12 )
MTASVFVAGKLLPETMEALSKWDVKAFSGEENITEAELINNVTEVDAIICPLSSPISAKVLESAKNLKIVANIGAGFDNIDVKKAQELGIAVTNTPDVSTEATAELTLGLILDVARRISEGDRLCRETPEQFKGWAPTFFLGTELSGKTLGIIGLGRIGQAVAKRAAAFGMNIIYSGHQPKEAAKEWNAEFVSQKELLKRSDVVTIHAAYSPSLKHLLNETTLKTMKSSAFLINAARGPVVEEAALIKALETGVIAGAALDVFEFEPKIGEDFAKLDNVVLTPHIGNATVETRAAMGKIAIANVEAVLAGKAPLHSVY
Atome Classification :
(34 SA)
.........10...-.....-20---........30........-40........50........60...-.....70........80........90........100.......110.....-------..120.....--..130..--...--..140.......150.......160.......170-..-.-....180...--.....190.-..-.....200.......210.......220.......230.......240.......250.......260.....-..270..--.....--..280.......290.......300.......310......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
A
S
V
F
V
A
G
KL
L
P
E
-
T
M
E
A
L
-
S
K---WD
V
K
AFSGEENI
T
E
A
E
L
I
-
N
N
V
T
E
V
D
A
I
ICPLSSP
I
S
A
K
V
L
E
SA-KN
L
K
I
V
A
NIGAGFDNI
D
V
K
K
A
Q
EL
G
I
A
V
TNTPDVSTE
A
T
A
E
L
T
L
G
L
I
L
D
V
A
R
R
-------
I
S
E
G
D
R
L
C
R
E--
T
P
E
Q
FKG--WA
P
--
T
F
F
L
GTELSG
K
T
L
G
I
I
G
L
G
R
I
G
Q
A
V
A
K
R
A
A
A
FG
M
N
-
I
I
-Y-SGHQ
P
K
-
E
A
A
--
K
E
W
N
A
E
-
F
V
-
S
Q
-
K
E
L
LKRS
D
V
V
T
I
H
AAY
S
P
S
L
K
H
L
L
N
E
T
T
L
K
T
MKS
S
A
F
L
I
NAARGP
V
V
E
E
A
A
L
I
K
A
L
E
TGVIAG
A
A
L
D
V
F
EFEP-KI
G
--
E
D
--
F
A
K
LD--
N
V
V
LTPHIGN
A
T
V
E
T
R
AAMG
K
I
A
I
A
N
V
E
A
V
LAGKAPLHSVY---
1
PsiBlast_PDB
96.68
46%
-115
* C1 *
2DBR
3
GYAR_PYRHO
A:
[1-317]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
E
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
26
PsiBlast_CBE
95.38
46%
-113
- C1 -
2DBR
3
GYAR_PYRHO
B:
[1-317]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
E
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
22
PsiBlast_CBE
95.26
46%
-110
- C1 -
2DBR
3
GYAR_PYRHO
F:
[1-317]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
E
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
2
PsiBlast_PDB
94.92
46%
-113
- C1 -
2DBZ
3
GYAR_PYRHO
A:
[1-317]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
E
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
25
PsiBlast_CBE
94.87
46%
-112
- C1 -
2DBR
4
GYAR_PYRHO
C:
[1-317]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
E
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
24
PsiBlast_CBE
94.76
46%
-114
- C1 -
2DBR
3
GYAR_PYRHO
D:
[1-317]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
E
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
21
PsiBlast_CBE
94.67
46%
-113
- C1 -
2DBZ
3
GYAR_PYRHO
B:
[1-317]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
E
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
23
PsiBlast_CBE
94.20
46%
-111
- C1 -
2DBR
3
GYAR_PYRHO
E:
[1-317]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
E
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
112
HHSearch
93.59
46%
-109
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[1-320]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
-
G
I
K
M
L
-
E
D
E
--
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
-
Y
S
R
T
R
K
-
E
E
V
E
-
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
-----
7
PsiBlast_PDB
92.14
36%
-119
- C1 -
2GCG
3
GRHPR_HUMAN
A:
[11-326]
----
V
F
V
T
R
R
I
P
A
E
-
G
R
V
A
L
-
A
R
AAD
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
-
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
-------
L
P
E
A
I
E
E
V
K
N
--
G
--
G
W
T
S
--
W
K
P
--
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
-
Y
-
T
G
R
Q
P
R
P
E
E
A
--
A
E
F
Q
A
E
-
F
V
-
S
T
-
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
--
H
P
--
L
L
T
L
K
--
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-
P
M
P
S
-----
4
PsiBlast_PDB
92.10
47%
-124
- C1 -
1WWK
1
?
A:
[5-307]
---
K
V
L
V
A
A
P
L
H
E
K
-
A
I
Q
V
L
-
K
D
---
A
G
L
E
V
I
Y
-
E
E
Y
P
D
E
D
R
L
V
-
E
L
V
K
D
V
E
A
I
I
V
R
S
K
P
K
V
T
R
R
V
I
E
S
A
-
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
-------
I
A
F
A
D
R
K
M
R
E
--
G
V
-------
W
A
K
--
K
E
A
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
-
I
L
L
Y
-
D
P
Y
P
N
E
-
E
R
A
--
K
E
V
N
G
K
-
F
V
-
D
L
-
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
--
L
P
--
K
D
HP
L
T
K
F
D
--
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
-----------
31
PsiBlast_CBE
91.18
36%
-117
- C1 -
2GCG
5
GRHPR_HUMAN
C:
[11-326]
----
V
F
V
T
R
R
I
P
A
E
-
G
R
V
A
L
-
A
R
AAD
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
-
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
-------
L
P
E
A
I
E
E
V
K
N
--
G
--
G
W
T
S
--
W
K
P
--
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
-
Y
-
T
G
R
Q
P
R
P
E
E
A
--
A
E
F
Q
A
E
-
F
V
-
S
T
-
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
--
H
P
--
L
L
T
L
K
--
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-
P
M
P
S
-----
32
PsiBlast_CBE
91.02
36%
-118
- C1 -
2GCG
3
GRHPR_HUMAN
B:
[11-326]
----
V
F
V
T
R
R
I
P
A
E
-
G
R
V
A
L
-
A
R
AAD
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
-
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
-------
L
P
E
A
I
E
E
V
K
N
--
G
--
G
W
T
S
--
W
K
P
--
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
-
Y
-
T
G
R
Q
P
R
P
E
E
A
--
A
E
F
Q
A
E
-
F
V
-
S
T
-
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
--
H
P
--
L
L
T
L
K
--
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-
P
M
P
S
-----
27
PsiBlast_CBE
90.41
47%
-125
- C1 -
1WWK
1
?
B:
[5-305]
---
K
V
L
V
A
A
P
L
H
E
K
-
A
I
Q
V
L
-
K
D
---
A
G
L
E
V
I
Y
-
E
E
Y
P
D
E
D
R
L
V
-
E
L
V
K
D
V
E
A
I
I
V
R
S
K
P
K
V
T
R
R
V
I
E
S
A
-
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
-------
I
A
F
A
D
R
K
M
R
E
--
G
V
-------
W
A
K
--
K
E
A
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
-
I
L
L
Y
-
D
P
Y
P
N
E
-
E
R
A
--
K
E
V
N
G
K
-
F
V
-
D
L
-
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
--
L
P
--
K
D
HP
L
T
K
F
D
--
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
-------------
124
HHSearch
90.37
43%
-123
- C1 -
2CUK
-
?
A:
[1-310]
--
M
R
V
L
V
T
R
T
L
P
G
K
-
A
L
D
R
L
-
R
E
R
G-
L
E
V
E
V
H
R
G
L
F
-
L
P
K
A
E
L
L
-
K
R
V
E
G
A
V
G
L
I
P
T
V
E
D
R
I
D
A
E
V
M
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
-------
V
V
E
G
A
A
Y
A
R
D
--
G
L
W
K
A
W
----
H
P
--
E
L
L
L
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
-
V
V
-
Y
-
H
A
R
T
P
K
-
P
L
P
------
Y
P
-
F
L
-
S
L
-
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
-
G
H
L
F
G
A
G
L
D
V
T
D
P
E
P
-
L
P
P
G-
H
P
--
L
Y
A
L
P
--
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
----
28
PsiBlast_CBE
90.33
36%
-122
- C1 -
2WWR
1
GRHPR_HUMAN
C:
[11-326]
----
V
F
V
T
R
R
I
P
A
E
-
G
R
V
A
L
-
A
R
AAD
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
-
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
-------
L
P
E
A
I
E
E
V
K
N
--
G
--
G
W
T
S
--
W
K
P
--
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
-
Y
-
T
G
R
Q
P
R
P
E
E
A
--
A
E
F
Q
A
E
-
F
V
-
S
T
-
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
--
H
P
--
L
L
T
L
K
--
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-
P
M
P
S
-----
8
PsiBlast_PDB
89.61
36%
-120
- C1 -
2WWR
1
GRHPR_HUMAN
A:
[11-326]
----
V
F
V
T
R
R
I
P
A
E
-
G
R
V
A
L
-
A
R
AAD
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
-
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
-------
L
P
E
A
I
E
E
V
K
N
--
G
--
G
W
T
S
--
W
K
P
--
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
-
Y
-
T
G
R
Q
P
R
P
E
E
A
--
A
E
F
Q
A
E
-
F
V
-
S
T
-
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
--
H
P
--
L
L
T
L
K
--
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-
P
M
P
S
-----
122
HHSearch
88.98
47%
-117
- C1 -
1WWK
1
?
A:
[4-307]
--
M
K
V
L
V
A
A
P
L
H
E
K
-
A
I
Q
V
L
-
K
D
A
G-
L
E
V
I
Y
E
E
Y
---
P
D
E
D
R
L
V
-
E
L
V
K
D
V
E
A
I
I
V
R
S
K
P
K
V
T
R
R
V
I
E
S
A
-
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
-------
I
A
F
A
D
R
K
M
R
E
--
G
V
W
A
K
K
---------
E
A
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
-
I
L
-
L
-
Y
D
P
Y
P
N
-
E
E
R
A
-
K
E
V
N
G
K
-
F
V
-
D
L
-
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
L
P
K
D-
H
P
--
L
T
K
F
D
--
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
-----------
29
PsiBlast_CBE
88.93
36%
-118
- C1 -
2WWR
1
GRHPR_HUMAN
B:
[11-326]
----
V
F
V
T
R
R
I
P
A
E
-
G
R
V
A
L
-
A
R
AAD
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
-
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
-------
L
P
E
A
I
E
E
V
K
N
--
G
--
G
W
T
S
--
W
K
P
--
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
-
Y
-
T
G
R
Q
P
R
P
E
E
A
--
A
E
F
Q
A
E
-
F
V
-
S
T
-
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
--
H
P
--
L
L
T
L
K
--
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-
P
M
P
S
-----
30
PsiBlast_CBE
88.80
36%
-112
- C1 -
2GCG
6
GRHPR_HUMAN
D:
[11-326]
----
V
F
V
T
R
R
I
P
A
E
-
G
R
V
A
L
-
A
R
AAD
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
-
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
-------
L
P
E
A
I
E
E
V
K
N
--
G
--
G
W
T
S
--
W
K
P
--
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
-
Y
-
T
G
R
Q
P
R
P
E
E
A
--
A
E
F
Q
A
E
-
F
V
-
S
T
-
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
--
H
P
--
L
L
T
L
K
--
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-
P
M
P
S
-----
3
PsiBlast_PDB
88.34
46%
-103
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[21-317]
---------------------
D
E
---
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
-
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
-------
V
V
K
G
D
R
F
V
R
S
--
G
E
W
K
K
R
G
VA
W
H
P
--
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
-
Y
Y
S
R
T
R
K
E
-
E
V
E
--
R
E
L
N
A
E
-
F
K
-
P
L
-
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
N
--
E
E
--
L
F
K
L
D
--
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
--------
116
HHSearch
87.70
35%
-111
- C1 -
2GCG
3
GRHPR_HUMAN
A:
[8-328]
-
L
M
K
V
F
V
T
R
R
I
P
A
E
-
G
R
V
A
L
-
A
R
AAD
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
-
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
-------
L
P
E
A
I
E
E
V
K
N
--
G
G
W
T
S
W
K
----
P
--
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
-
R
F
-
L
-
Y
T
G
R
Q
P
-
R
P
E
EA
A
E
F
Q
A
E
-
F
V
-
S
T
-
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
T
N-
H
P
--
L
L
T
L
K
--
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
P
M
P
S
E
L
----
35
PsiBlast_CBE
84.27
44%
-110
- C1 -
2CUK
1
?
C:
[32-310]
-------------------------------------
L
P
K
A
E
L
L
-
K
R
V
E
G
A
V
G
L
I
P
T
V
E
D
R
I
D
A
E
V
M
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
-------
V
V
E
G
A
A
Y
A
R
D
--
G
--
L
W
K
A
--
W
H
P
--
E
L
L
L
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
-
V
V
-
Y
-
H
A
R
T
P
-------
K
P
L
P
Y
P
-
F
L
-
S
L
-
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
-
G
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P
G
--
H
P
--
L
Y
A
L
P
--
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
----
128
HHSearch
76.28
34%
-99
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[21-338]
-
M
P
L
V
A
L
L
D
G
R
D
C
T
V
E
M
P
I
L
-
K
D
V--
A
T
V
A
F
C
D
A
---
Q
S
T
Q
E
I
H
E
K
V
L
N
E
A
V
G
A
L
M
Y
H
T
I
T
L
T
R
E
D
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
-------
A
T
W
L
H
Q
A
L
R
E
--
G
T
R
V
Q
S
V
--
E
Q
I
R
E
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
-
F
-
Y
D
P
Y
L
S
-
D
G
V
E
-
R
A
L
G
L
Q
R
V
S
-
T
L
-
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
SQ
G
P
--
L
K
D
A
P
--
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------
104
Fugue
74.43
33%
-91
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[21-346]
M
P
-
L
V
A
L
L
D
G
R
D
C
T
-
V
E
M
P
I
-
L
K
---
D
V
A
T
V
A
F
C
D
A
Q
S
T
Q
E
I
H
E
-
K
V
L
N
E
A
V
G
A
L
M
Y
H
T
I
T
L
T
R
E
D
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
-------
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
E
Q
--
I
R
E
--
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
-
F
Y
D
P
Y
L
S
D
-
G
V
E
--
R
A
L
G
L
Q
-
R
V
S
T
L
-
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
GP
L
K
D
A
P
--
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
D
S
L
K
N
CVN
20
PsiBlast_PDB
73.91
40%
-97
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[80-338]
------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
--
Q
--
S
V
E
Q
I
R
E
--
V
A
S
--
G
---
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
S
D
-
G
V
E
--
R
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
--
G
P
L
K
D
AP
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------
6
PsiBlast_PDB
73.49
41%
-101
- C1 -
3BAZ
1
HPPR_PLESU
A:
[78-332]
--------------------------------------------------------------
D
A
E
L
I
D
A
L
-
P
K
L
E
I
V
S
S
F
S
V
G
L
D
K
V
D
L
I
K
C
E
E
K
G
V
R
V
T
N
T
P
D
V
L
T
D
D
V
A
D
L
A
I
G
L
I
L
A
V
L
R
R
-------
I
C
E
C
D
K
Y
V
R
R
--
G
A
W
K
F
G
--------
D
F
K
L
T
T
K
F
S
G
K
R
V
G
I
I
G
L
G
R
I
G
L
A
V
A
E
R
A
E
A
F
D
C
P
-
I
S
-
Y
-
F
S
R
S
K
K
-
P
N
T
--
N
--
Y
T
Y
-
Y
G
-
S
V
-
V
E
L
A
S
N
S
D
I
L
V
V
A
C
P
L
T
P
E
T
T
H
I
I
N
R
E
V
I
D
A
L
G
P
K
G
V
L
I
N
I
G
R
G
P
H
V
D
E
P
E
L
V
S
A
L
V
E
G
R
L
G
G
A
G
L
D
V
F
E
R
E
P
-
E
V
P
--
E
K
--
L
F
G
L
E
--
N
V
V
L
L
P
H
V
G
S
G
T
V
E
T
R
K
V
M
A
D
L
V
V
G
N
L
E
A
H
F
S
G
K
P
L
L
T
P
V
----
45
PsiBlast_CBE
73.28
40%
-103
- C1 -
3GA0
2
CTBP1_RAT
A:
[83-341]
------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
--
Q
--
S
V
E
Q
I
R
E
--
V
A
S
--
G
---
A
A
R
I
R
G
E
T
L
G
I
I
G
L
E
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
S
D
-
G
I
E
--
R
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
--
G
P
L
K
D
AP
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------
40
PsiBlast_CBE
73.07
40%
-97
- C1 -
4U6Q
3
CTBP1_HUMAN
A:
[80-338]
------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
--
Q
--
S
V
E
Q
I
R
E
--
V
A
S
--
G
---
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
S
D
-
G
V
E
--
R
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
--
G
P
L
K
D
AP
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------
39
PsiBlast_CBE
73.02
40%
-94
- C1 -
4U6S
3
CTBP1_HUMAN
A:
[80-338]
------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
--
Q
--
S
V
E
Q
I
R
E
--
V
A
S
--
G
---
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
S
D
-
G
V
E
--
R
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
--
G
P
L
K
D
AP
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------
41
PsiBlast_CBE
72.49
40%
-95
- C1 -
4LCE
2
CTBP1_HUMAN
A:
[80-338]
------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
--
Q
--
S
V
E
Q
I
R
E
--
V
A
S
--
G
---
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
S
D
-
G
V
E
--
R
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
--
G
P
L
K
D
AP
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------
42
PsiBlast_CBE
72.33
40%
-98
- C1 -
2HU2
3
CTBP1_RAT
A:
[83-341]
------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
--
Q
--
S
V
E
Q
I
R
E
--
V
A
S
--
G
---
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
S
D
-
G
I
E
--
R
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
--
G
P
L
K
D
AP
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------
44
PsiBlast_CBE
71.97
40%
-94
- C1 -
1HKU
4
CTBP1_RAT
A:
[83-341]
------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
--
Q
--
S
V
E
Q
I
R
E
--
V
A
S
--
G
---
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
S
D
-
G
I
E
--
R
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
--
G
P
L
K
D
AP
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------
43
PsiBlast_CBE
71.38
40%
-98
- C1 -
1HL3
1
CTBP1_RAT
A:
[83-341]
------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
--
Q
--
S
V
E
Q
I
R
E
--
V
A
S
--
G
---
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
S
D
-
G
I
E
--
R
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
F
--
S
Q
--
G
P
L
K
D
AP
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
--------