@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0086: (2016-03-12 )
LKKNILVVIIVSVLAISAIVSAFFLMRDDAYAIETEGFTYSPKGKVVDFSSEAKYNDTWINNEKTITDKKEMKPINLARTLFLKDGRIQFLGKSVAVKSASDLIELPSKTSITESKGSYKAKSDSNKTLAQLPKGTVVKLAEGRYIILDNAYLKNKQGLNKKLPKNVLVSIDENKKVMLMGDKTIEELGGDDAYIEMENNHYHFDLKKEMLVSQTAKETDIDIRSIKVEIDDNAEKRSLKTAKETEKETTKDSTEKESEKQSNDASGQKSAQNNERSESKDDQTQDASGNNTNGSANNNTARSNGTGGSNSDTNGSQPGGTQNKPNEGDVNKANEIIKKLNEAENTNTFQVPIVDVNLTVKGQVAAAKLKLTDSSKRLNSLEAILYDSKNNIVKKEKLNSTKANQNFTFNNLKYGETYQVVVQGSYKSASNKNQDTIFFRQTVEAKPVVLTPKVTERGEDYMKAELTATELYGHIDKLVLKIKENNSNVITSQKVTVDASQLTKDGQVEVKFNSLSSDKEYIIEMEELIVDGKNVTDDGWYFISSTLKAKPTIEGLNLSYSTDKGEFVASPVNLVDRDESITSIRYVAYLEDDYKVNGSNAKEYAYSVVDANQKKTAVKVGRTVDMNDGNYIFVGYISGNNGQSDYTFATPASNSVVVGKKTKPTVEFSLKEAEQDKLTINYEVFDADNTLLFDNLTHPTLKLYKSDAQGMYSGNPVATVDLTKKSDITNLLEFDGLESEAYYVVVMTGSYNLDDGAGIMVDELIGQSSVFRTTEITKVNASFSLDSVDTTKVAINVKLSDAAVNLNDANLKIYEKKTNTLVKTVPLHGDFEKLMSDSGNSYLFENLSINKEYLVKVEDGYDSGMNHVPVEGQFIFKTKKESPETDKVLLDYKASEMKLGGLAGIAATEKPLIDDYNAVSSITYSIYKADDLNTPLVEQEVSTAADFEKNVYFDLTNKLLGRGYSYVIKADVVWNDNYEDHHIEISSDTIQIKKEKPTVEYEILSRTASEIKLNVYVEDEEESIVPGTLEITSTTGGNEQLQSGKNNVTLPLSSEGTTTIKTTGDYIITSGSSAISDIFMTKQLAALNTTTPQVGAKIAMDASGKSMTIAPEPNAVAKTSVMRTKYDLKDAASSKPDYSITKSGPNQFNTQNLNLPLGNIWFDNSYQLTLDMKMNYTENKIDNQNLANNYYLSIGNGASFVSSLSGAVSTTNNVNSADVFKVTKASTDLEGNISGVTFKNIWTDKYIAYRNGILISNSETPDSFKLIRQADGSYVPELSGRYVNFSVGLVTDEAAGSKIDLYSTQEKLEQVSEAISVKALEEPAISAENIGVYDKRVKLDVIGEDKDNTTVKKANKNELFVNVYKADGTTLVNSIRVDGLPTRDVSVTELSPDTDYVVKVEGKYDLLDGNGEKDKVYYSETIKTEKSLPSMTSTDYSWSPAYGQRAIKGKIDFADESSVLTNIEYRLYDAATISSSLSNLVALEQELGNKTPVSTFDNMTNNPEFSIYNGSGTQNFVSGKTYVIAAYMKTSLTRAPIFLSDAKAVYISPPSNVSAPITLENVSTREATLKFSYNDPQSYFVGGTNKDFQYVLKNTTTGTEVKKGSFQGGNTASWINTFEDLEPATGYTLTISTQYDNLNGGLVRAWNTSFNFTTDDEYVTSNSLTIQLDAGAKAVKLQAKEVRPGSTTIENIKMEFYELIDYGGNNERTQLVETKNITLPSSYPATIAADFNVAGKKKNQSFLGKMIVTYRTPTNEVKTYEKTSNFITLQEDIAAGLKSFKSVRATNDALEVKLDIPQDNSTDKGSYTYELKNENGDVIDTEKVAAEDISKTVSLSMEPTSNYTLTVINPDNQPVALYQGNNEENNLKAEIKKDSFTLMSNNTADAKTTMTVTVEPKELTAWQTVQSWFGKDFTETYNIQKDELDTGVKIDTNYQDTKVTVEETKSGKNFGIIELEESK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170..---------.....180.......190.......200.......210---.........220.......230.......240.---......250.......260......-.270.......280.......290.......300.......310.......320.......330.......340.......350-----------.......360........370.......380.......--------------390.......400....----...410.......420.......430.......440.......450--........460.......470.......480.......490.......500.......510.......520.......530.......540..---.....550.......560.......570.......580--.........590.......600.......610.......620-.......630.......640.......650-........---------660....---------...670........680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500........1510......1520......1530......1540......1550......1560......1570.....--.1580......1590......--------1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LKK
N
I
L
V
V
I
I
V
S
V
L
A
I
S
A
I
V
S
A
F
F
L
MRDD
A
Y
A
I
ETEG
F
T
YSPKG
K
V
V
DFSSEAKYNDTWINNEKTITDKKEMKP
I
N
L
A
R
T
L
F
LKDG
R
I
Q
F
LGKSVAVK
S
A
S
D
L
I
ELPSKTSITESKGSYKAKSDSN
K
T
L
A
QLPKG
T
V
V
K
LAEG
R
Y
I
I
LDN
A
Y
LKNKQGLNKKLPK
N
V
L
V
S
IDEN---------
K
K
V
M
L
MGD
K
T
I
E
E
LGGD
D
A
Y
I
E
MENN
H
Y
H
F
D
L
K
K
E
M
-----
L
V
S
QTAKETD
I
D
I
R
S
I
K
V
E
IDDNAEKRSL
K
T
A
K
---
E
TEKETTKDSTE
K
E
S
EKQSNDASGQ-KSAQNNERSESKDDQTQDASGNNTNGSANNNTARSNGTGGSNSDTNGSQPGGTQNKPNEGDV
N
K
A
N
E
I
I
K
K
L
N
EAENT
N
T
F
Q
V
P
-----------
I
V
D
V
N
L
T
V
-
K
G
Q
V
A
A
A
K
L
K
LTD
S
S
K
R
L
N
S
L
E
A
I
LYDSK--------------NN
I
V
K
K
EKLNSTKANQN----FTFNNLKYG
E
T
Y
Q
V
V
V
Q
GSYKSASNKNQ
D
T
I
F
F
R
QTVEAK
P
V
V
LT---PKVTERG
E
D
Y
M
K
A
E
L
T
A
T
E
L
Y
G
H
I
D
K
L
V
L
K
I
KENNS
N
V
I
T
S
Q
K
V
T
V
D
A
S
QLTKD
G
Q
V
E
V
K
FNSLSSD
K
E
Y
I
I
E
M
E
E
L
IVDGKNVTDD
G
W
Y
F
I
S
---STLKAKPTIEGL
N
L
S
YSTDKG
E
F
VASPVNLVDRDES----I
T
S
I
R
Y
V
A
Y
LED
D
Y
K
VNGSN
A
K
E
Y
A
Y
S
VVDANQK
K
T
A
V
KVG
R
-
T
V
DMNDG
N
Y
I
F
V
G
Y
I
SGNNGQS
D
Y
T
F
ATP--ASN
S
V
V
VG---------KKTK
P
T
V
---------
E
F
S
LK-EAEQD
K
L
T
I
N
Y
E
V
FDADN
T
L
L
FDNLTH
P
T
L
K
L
Y
KSDAQGMYSGN
P
V
A
T
V
D
LTKKS
D
I
T
N
L
L
E
FDGLESE
A
Y
Y
V
V
V
M
TGSYNLDDGA
G
I
M
V
D
E
LIGQSSV
F
R
T
T
E
I
T
K
V
N
A
S
F
SLDSVD
T
T
K
V
A
I
N
V
K
LS
D
A
A
V
NLNDA
N
L
K
I
Y
EKKTN
T
L
V
K
T
VPLHG
D
F
E
K
L
M
SDSGN
S
Y
L
F
ENLSI
N
K
E
Y
L
V
K
VEDGYDSGMNHVPVE
G
Q
F
I
F
K
TKKESPET
D
K
V
L
L
DYKASEMKLGGLAGIAATEKPLID
D
Y
N
A
V
S
S
I
T
Y
S
I
Y
KADDLNT
P
L
V
E
Q
E
V
S
T
A
A
DFEKN
V
Y
F
D
L
T
N
K
L
LGRG
Y
S
Y
V
I
K
A
D
V
V
WNDNYE
D
H
H
I
E
ISS
D
T
I
Q
I
KKEKPTV
E
Y
E
I
L
SRTAS
E
I
K
L
N
V
Y
V
EDEEESIVPG
T
L
E
I
T
STTGG
N
E
Q
L
QSGKN
N
V
T
L
P
LSSEG
T
T
T
I
K
TTG
D
Y
I
I
TSGS
S
A
I
S
D
I
F
M
T
K
Q
L
A
ALNTTTPQV
G
A
K
I
A
MDASG
K
S
M
T
IAPEPNA
V
A
K
T
S
V
M
R
T
KYDLKDAASSKPD
Y
S
ITKSGPNQFNTQNLNLPL
G
N
I
W
FDN
S
Y
Q
L
T
L
D
M
K
MNYTENKIDNQNLAN
N
Y
Y
L
S
IGN
G
A
S
F
V
S
S
L
SGAVSTTNNVNSA
D
V
F
K
V
TKASTDLEGNIS
G
V
T
F
K
NIWTD
K
Y
I
A
Y
RN
G
I
L
I
SNSET
P
D
S
F
K
L
I
R
QADGSYVPELSG
R
Y
V
N
F
S
V
G
L
V
TDEAAG
S
K
I
D
L
Y
S
T
Q
E
K
L
E
Q
V
S
E
A
I
S
V
KALEEPAISAENIGVY
D
K
R
V
K
L
D
V
I
GEDKDN
T
T
V
KKANKN
E
L
F
V
N
V
YKADG
T
T
L
V
N
S
I
RVDGLPTRD
V
S
V
T
ELSPDT
D
Y
V
V
K
VE
G
K
Y
D
LLDGNGEK
D
K
V
Y
Y
S
ETIKTEKSLPSMTSTDYSWS
P
A
YGQRAIKGKIDFADESS
V
L
T
N
I
E
Y
R
L
Y
D
A
A
T
I
S
S
S
L
S
N
L
V
A
L
E
Q
E
LGNKTPV
S
T
FDNMTN--NP
E
F
S
I
YNGSGTQNFVSG
K
T
Y
V
I
A
A
Y
M
K
TSLTRA
P
I
F
LSDA
K
A
V
Y
ISPPSNVSA
P
I
T
L
ENVSTR
E
A
T
L
K
F
SYNDPQ
S
--
Y
F
VGGTNK
D
F
Q
Y
V
LKNTTTGT--------EVKKGSFQGGN
T
A
S
W
I
N
T
F
EDLEPAT
G
Y
T
L
T
I
S
T
Q
YDNLNG
G
L
V
R
A
WNTSFNFTTDDEYVTSN
S
L
T
I
Q
LDAG
A
K
A
V
K
L
Q
A
K
EVRPGS
T
T
I
E
N
I
K
M
E
F
Y
E
L
I
DYGGNN
E
R
T
Q
L
V
E
TKNITLPSSYP
A
T
I
A
A
DFNVAGKKK
N
Q
S
F
L
G
K
M
I
V
T
Y
RTPTNEV
K
T
YEKTS
N
F
I
T
L
Q
E
D
I
A
A
G
L
K
S
F
K
S
V
RATN
D
A
L
E
V
K
L
DIPQDNSTDKG
S
Y
T
Y
E
L
KNENGDVI
D
T
E
K
V
A
A
E
D
I
S
K
T
V
S
L
S
MEPTS
N
Y
T
L
T
V
INPDNQ
P
V
A
L
Y
QGNNEENN
L
K
A
E
IKKD
S
F
T
L
MSNNTADA
K
T
T
M
T
V
T
VEP
K
E
L
T
A
W
Q
T
V
Q
S
W
FGKD
F
T
E
TYNI
Q
K
D
ELDTG
V
K
I
DTNYQD
T
K
V
T
V
E
ETKSGK
N
F
G
I
I
E
LEESK
10
PsiBlast_PDB
67.46
24%
57
- C3 -
1E5U
-
I:
[24-186]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
Q
Y
G
Q
V
N
L
K
A
S
G
G
N
G
K
---
Y
T
W
R
S
A
N
P
A
I
A
S
V
D
A
S
S
G
Q
V
T
L
K
E
K
G
T
T
T
I
S
V
I
S
S
D
N
Q
T
A
T
Y
T
I
A
T
P
----
N
S
L
I
V
P
---------
N
M
S
K
R
V
T
YNDAVNTCK
N
F
G
G
K
L
P
S
S
Q
N
E
L
E
N
V
F
K
A
W
G
A
A
N
K
Y
E
Y
Y
K
S
S
Q
T
I
I
S
W
V
Q
Q
T
A
Q
D
A
K
S
G
-
V
A
S
T
Y
D
L
V
K
Q
N
P
L
N
N
I
---
K
A
S
E
S
N
A
Y
A
T
C
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.62
24%
66
- C2 -
1AGX
-
ASPQ_ACIGL
A:
[22-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
A
T
Y
S
A
A
K
V
P
V
D
A
L
---------
I
K
A
V
P
Q
V
N
D
L
A
N
I
T
G
I
Q
A
L
Q
V
A
S
E
S
I
T
D
K
E
L
L
S
L
A
R
Q
V
N
D
L
V
K
K
P
S
V
N
G
V
V
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
V
V
H
T
D
K
P
I
V
L
V
G
S
M
R
P
S
T
A
L
S
A
D
G
P
L
N
-------
L
Y
S
A
V
A
L
A
S
S
N
E
A
K
N
K
G
V
-
M
V
L
M
N
D
S
I
F
A
A
R
D
V
T
K
G
I
N
I
H
T
-
H
A
F
V
S
Q
WG
A
L
G
T
L
V
E
G
K
P
Y
W
F
R
SSV
K
K
H
T
N
N
S
---------
E
F
N
I
E
-
K
I
Q
G
D
A
L
P
G
V
Q
I
V
Y
G
S
D
N
M
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.05
30%
155
- C2 -
3BZC
-
?
A:
[508-651]
------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
A
H
R
D
A
N
GAFRT
R
D
E
L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
---
F
L
R
V
M
N
G
D
N
P
L
D
A
S
A
V
H
PET
Y
P
L
V
Q
R
I
A
A
D
T
E
R
D
I
R
S
L
---
I
G
D
S
A
F
L
K
R
L
D
P
K
K
FTD
E
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.90
30%
157
- C2 -
3BZK
-
?
A:
[508-651]
------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
A
H
R
D
A
N
GAFRT
R
D
E
L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
---
F
L
R
V
M
N
G
D
N
P
L
D
A
S
A
V
H
PET
Y
P
L
V
Q
R
I
A
A
D
T
E
R
D
I
R
S
L
---
I
G
D
S
A
F
L
K
R
L
D
P
K
K
FTD
E
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
63.43
21%
105
- C- -
1ZLG
-
KALM_HUMAN
A:
[548-653]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
P
E
N
L
S
A
S
F
I
V
Q
D
V
N
---
I
T
G
H
F
S
W
K
M
A
K
A
--
N
-
L
Y
Q
P
M
T
G
F
Q
V
T
W
A
E
V
T
T
E
S
RQNSLP
N
S
I
I
S
Q
S
Q
I
L
P
S
D
H
Y
V
--
L
T
V
P
N
L
R
P
S
T
L
Y
R
L
E
V
Q
V
L
T
P
----
G
G
E
G
P
A
T
-
I
K
T
F
R
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.31
30%
175
- C2 -
2OCE
-
?
A:
[508-651]
------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
A
H
R
D
A
N
GAFRTRDEL
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
---
F
L
R
V
M
N
G
D
N
P
L
D
A
S
A
V
H
PET
Y
P
L
V
Q
R
I
A
A
D
T
E
R
D
I
R
S
L
---
I
G
D
S
A
F
L
K
R
L
D
P
K
K
FTD
E
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
54.81
9%
84
- C1 -
4E9L
-
?
A:
[678-991]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
A
G
P
L
D
A
A
H
S
S
I
T
L
N
P
D
K
P
V
-
V
G
G
T
V
T
A
I
W
T
A
K
D
A
N
D
N
P
V
T
G
L
N
P
D
A
P
S
L
S
G
A
A
A
A
G
S
T
A
S
G
W
T
D
N
G
D
G
T
W
T
A
Q
I
S
L
G
T
T
A
G
E
L
D
V
M
P
K
L
N
G
Q
D
A
A
A
N
A
A
K
V
T
V
V
ADALSSNQ
S
K
V
S
V
A
E
D
H
V
K
-
A
G
E
S
T
T
V
T
L
V
A
K
D
A
H
G
N
A
I
S
G
L
S
L
S
A
S
L
T
--------------
G
T
A
S
E
G
A
T
V
S
S
W
T
E
K
G
D
G
S
Y
V
A
T
L
T
T
G
G
K
T
G
E
L
R
V
M
P
L
F
N
G
Q
P
A
A
T
E
A
A
Q
L
T
V
I
A
G
E
M
S
S
A
N
S
T
L
V
A
DN
K
T
P
T
V
K
T
T
T
E
L
T
F
T
M
K
D
A
Y
G
N
P
V
T
G
L
K
P
D
A
P
V
F
S
G
A
A
S
T
G
S
E
R
P
S
A
G
N
W
T
E
K
G
N
G
V
Y
V
S
T
L
T
L
G
S
A
A
G
Q
L
S
V
M
---
P
R
V
N
G
Q
N
A
V
A
Q
P
L
V
L
N
V
---
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
52.77
15%
157
- C4 -
1EGJ
-
A:
[1-101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
M
A
P
P
S
L
N
V
T
K
D
G
D
S
Y
S
L
R
W
E
---
T
M
K
M
R
Y
E
H
I
D
H
T
F
E
I
Q
Y
R
K
D
T
A
T
W
K
D
S
K
T
E
T
L
Q
N
A
H
S
M
A
L
P
A
L
E
P
S
T
R
Y
W
A
R
V
R
V
R
T
S
R
T
G
Y
N
G
I
W
S
E
W
S
E
A
R
S
W
D
T
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
47.39
14%
106
* C4 *
2B5I
1
IL2RB_HUMAN
B:
[101-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
N
L
R
L
M
A
P
I
S
L
Q
V
----
V
H
V
E
T
--
H
R
C
N
I
S
W
E
I
S
Q
A
SH
Y
F
E
R
H
L
E
F
E
A
R
T
L
S
P
G
----
H
--------
T
W
E
E
A
P
L
L
T
L
K
Q
K
Q
E
W
I
C
L
E
T
L
T
P
D
T
Q
Y
E
F
Q
V
R
V
K
P
L
Q
G
E
F
T
T
W
S
P
W
S
Q
P
L
A
F
R
T
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
45.87
23%
121
- C2 -
3OZX
1
?
A:
[82-179]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
N
E
L
K
I
V
H
K
I
Q
Y
V
E
Y
A
S
K
F
L
K
G
T
V
N
E
I
L
T
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
N
M
T
N
LW
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
------
L
V
A
A
S
L
---
L
R
E
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
45.16
27%
247
- C3 -
1LOF
3
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
Q
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
45.14
27%
248
* C3 *
1LOC
1
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
Q
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
44.83
27%
242
- C3 -
1LGB
2
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
P
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
44.48
27%
229
- C3 -
1LOE
-
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
Q
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
44.44
27%
238
- C3 -
1LOD
1
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
Q
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
44.32
22%
243
- C2 -
4CNF
4
?
A:
[69-177]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
E
V
I
E
K
M
M
K
I
--
T
N
N
F
D
D
A
-----------
I
R
D
V
D
L
K
I
A
T
S
S
I
A
D
--
G
D
L
L
R
K
S
I
R
P
I
D
L
E
R
L
I
K
D
K
K
V
A
F
I
F
G
R
ESVGLT
R
E
E
I
A
K
S
D
F
L
L
F
I
P
A
N
P
E
----
Y
P
V
L
N
L
S
H
A
--
V
G
I
V
L
Y
E
L
W
R
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
44.30
27%
236
- C3 -
1LGC
3
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
P
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
43.51
27%
241
- C3 -
1LOB
1
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
Q
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
43.49
27%
248
- C3 -
1LOG
1
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
Q
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
43.30
27%
235
- C3 -
1LOA
1
LECB_LATOC
A:
[6-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
T
K
F
G
P
D
Q
-----
Q
N
L
I
F
Q
G
D
G
Y
T
T
K
E
R
L
T
L
T
K
A
V
R
N
T
V
G
R
A
L
Y
S
S
P
I
H
I
W
D
S
K
T
G
N
V
A
N
F
V
T
S
F
T
F
V
I
D
A
P
N
S
Y
N
V
A
D
G
F
T
F
F
I
A
P
V
D
T
K
P
Q
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------