@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0090: (2016-03-12 )
LKTIHFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILELNEEFVGIGLIDKTNDILEGMHVGVSGKFIEVDLFEEMAGRIIDTTGKMLYEESEEKPTATSPLFCVTPAIMTIDSVTRPLNTGLAVIDSITPIGRGQRQLILGNRQSGKTQIAVDTIINQHDQNVHCIYVAIGLKAAYIAEVIETLRNHGAMEYSTVVATAASDSLTAQYLTPYAGMALAEALRDQGKDVLIILDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMNEEHGGGSITAIPMIETLSDDVTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSRIGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNALDDGSMKMVSDGRLLTELFKQKILSPLSVTELIVILYAFQNGFLTKIPPANIQTFKGLLLEKAHMHKDFESFSAQIEAINELNESHVEMLEEIIRETGRLFS
Atome Classification :
(20 SA)
.........10........20........30........40.......-.50-........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180...--------....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460...-.-....470.......480.......490......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
L
K
T
I
H
F
DMNKYETHV
D
L
E
Y
L
K
EHGRVEKISD
G
V
I
F
CSGLEN
A
A
L
H
Q
A
V
-
L
I
D-ERHR
G
V
I
L
E
LNEE
F
V
G
I
G
L
IDK
T
N
D
I
L
E
G
MHVGVSG
K
F
I
E
V
D
L
F
E
E
M
A
G
R
I
IDTT
G
K
M
L
Y
EESEEKPTATS
P
L
F
C
V
T
P
A
I
M
T
I
D
S
VTRPLNT
G
L
A
V
I
DSITPIGRG
Q
R
Q
L
I
L
GNRQSG
K
T
Q
I
A
V
D
T
I
INQHDQ
N
--------
V
H
C
I
Y
V
A
IG
L
K
A
A
Y
I
A
E
V
I
E
T
L
R
NHGA
M
E
Y
S
T
V
V
A
TAASDS
L
T
A
Q
Y
LTPYA
G
M
A
L
A
E
A
L
R
DQGK
D
V
L
I
I
L
D
D
L
T
K
H
A
D
A
Y
R
A
I
T
L
L
F
NRPPGREAYPGD
S
F
Y
I
H
S
S
L
L
E
R
A
V
Q
MNEEHGGG
S
I
T
A
I
P
M
I
E
TLSDD
V
T
A
YIP
T
N
V
I
S
ITDG
Q
L
F
L
K
S
D
L
FNRGQKP
A
V
D
VG
V
S
V
SRIGGDAQ
H
P
I
I
R
K
L
SK
N
L
T
L
I
L
S
Q
F
E
E
L
K
E
L
L
DFGNALDDGS
M
K
M
VSD
G
R
L
L
T
E
L
F
K
Q
KILS
P
L
S
V
T
E
L
I
V
I
L
Y
A
FQNGFLTKIPPA
N
I
Q
T
F
K
G
L
L
L
E
K
A
H
-
M
H
K
D
-
F
-
E
S
F
S
A
Q
I
E
A
I
N
E
L
N
E
S
H
V
E
M
L
E
E
I
I
R
E
TGRLFS
149
HHSearch
97.73
43%
-100
- C5 -
2R9V
4
ATPA_THEMA
A:
[29-513]
--------
K
S
F
E
E
K
I
---
D
L
E
D
T
G
K
V
I
Q
V
G
D
G
I
A
R
A
Y
G
L
N
K
V
M
V
S
E
L
V
-
E
F
V
E
T
G
V
K
G
V
A
F
N
L
E
E
D
N
V
G
I
I
I
L
G
E
Y
K
D
I
K
E
G
H
T
V
R
R
L
K
R
I
I
E
V
P
V
G
E
E
L
L
G
R
V
V
N
P
L
G
E
P
L
D
G
K
G
P
I
N
A
K
N
F
R
P
I
E
I
K
A
P
G
V
I
Y
R
K
P
V
D
T
P
L
Q
T
G
I
K
A
I
D
S
M
I
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
I
A
I
D
T
I
I
N
Q
K
G
Q
G
--------
V
Y
C
I
Y
V
A
I
G
Q
K
K
S
A
I
A
R
I
I
D
K
L
R
Q
Y
G
A
M
E
Y
T
T
V
V
V
A
S
A
S
D
P
A
S
L
Q
Y
I
A
P
Y
A
G
C
A
M
G
E
Y
F
A
Y
S
G
R
D
A
L
V
V
Y
D
D
L
S
K
H
A
V
A
Y
R
Q
L
S
L
L
M
R
R
P
P
G
R
E
A
Y
P
G
D
I
F
Y
L
H
S
R
L
L
E
R
A
V
R
L
N
D
K
L
G
G
G
S
L
T
A
L
P
I
V
E
T
Q
A
N
D
I
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
Y
L
E
P
G
L
F
Y
A
G
Q
R
P
A
I
N
V
G
L
S
V
S
R
V
G
G
S
A
Q
I
K
A
M
K
Q
V
A
G
M
L
R
I
D
L
A
Q
Y
R
E
L
E
T
F
A
Q
F
A
T
E
L
D
P
A
T
R
A
Q
I
I
R
G
Q
R
L
M
E
L
L
K
Q
E
Q
Y
S
P
M
P
V
E
E
Q
V
V
V
L
F
A
G
V
R
G
Y
L
D
D
L
P
V
E
E
V
R
R
F
E
K
E
F
L
R
F
M
H
-
E
K
H
Q
-
D
I
L
D
---
D
I
K
T
K
K
E
L
T
S
E
T
E
E
K
L
K
K
A
I
E
E
F
K
T
T
F
-
1
PsiBlast_PDB
96.77
42%
-100
- C5 -
2R9V
4
ATPA_THEMA
A:
[29-508]
--------
K
S
F
E
E
K
I
D
L
E
---
D
T
G
K
V
I
Q
V
G
D
G
I
A
R
A
Y
G
L
N
K
V
M
V
S
E
L
V
E
F
V
E
-
T
G
V
K
G
V
A
F
N
L
E
E
D
N
V
G
I
I
I
L
G
E
Y
K
D
I
K
E
G
H
T
V
R
R
L
K
R
I
I
E
V
P
V
G
E
E
L
L
G
R
V
V
N
P
L
G
E
P
L
D
G
K
G
P
I
N
A
K
N
F
R
P
I
E
I
K
A
P
G
V
I
Y
R
K
P
V
D
T
P
L
Q
T
G
I
K
A
I
D
S
M
I
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
I
A
I
D
T
I
I
N
Q
K
G
Q
G
--------
V
Y
C
I
Y
V
A
I
G
Q
K
K
S
A
I
A
R
I
I
D
K
L
R
Q
Y
G
A
M
E
Y
T
T
V
V
V
A
S
A
S
D
P
A
S
L
Q
Y
I
A
P
Y
A
G
C
A
M
G
E
Y
F
A
Y
S
G
R
D
A
L
V
V
Y
D
D
L
S
K
H
A
V
A
Y
R
Q
L
S
L
L
M
R
R
P
P
G
R
E
A
Y
P
G
D
I
F
Y
L
H
S
R
L
L
E
R
A
V
R
L
N
D
K
L
G
G
G
S
L
T
A
L
P
I
V
E
T
Q
A
N
D
I
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
Y
L
E
P
G
L
F
Y
A
G
Q
R
P
A
I
N
V
G
L
S
V
S
R
V
G
G
S
A
Q
I
K
A
M
K
Q
V
A
G
M
L
R
I
D
L
A
Q
Y
R
E
L
E
T
F
A
Q
F
A
T
E
L
D
P
A
T
R
A
Q
I
I
R
G
Q
R
L
M
E
L
L
K
Q
E
Q
Y
S
P
M
P
V
E
E
Q
V
V
V
L
F
A
G
V
R
G
Y
L
D
D
L
P
V
E
E
V
R
R
F
E
K
E
F
L
R
F
M
H
E
K
H
Q
D
I
L
-
D
D
I
K
T
K
K
E
L
T
S
E
T
E
E
K
L
K
K
A
I
E
E
----------
21
PsiBlast_CBE
96.51
42%
-102
- C5 -
2W6E
1
ATPA_BOVIN
C:
[63-544]
-----------
D
T
S
V
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
S
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
88
PsiBlast_CBE
96.32
42%
-102
- C5 -
1EFR
3
ATPA_BOVIN
C:
[20-501]
-----------
D
T
S
V
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKKK
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
80
PsiBlast_CBE
96.06
42%
-102
- C5 -
1BMF
3
ATPA_BOVIN
C:
[20-501]
-----------
D
T
S
V
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKKK
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
4
PsiBlast_PDB
96.06
42%
-105
- C5 -
2W6F
-
ATPA_BOVIN
A:
[24-501]
---------------
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
S
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
23
PsiBlast_CBE
95.71
42%
-103
- C5 -
2JJ2
24
ATPA_BOVIN
J:
[20-501]
-----------
D
T
S
V
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKKK
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
S
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
7
PsiBlast_PDB
95.69
42%
-105
- C5 -
2W6G
-
ATPA_BOVIN
A:
[24-501]
---------------
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
S
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
5
PsiBlast_PDB
95.42
42%
-105
- C5 -
2W6I
-
ATPA_BOVIN
A:
[24-501]
---------------
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
S
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
3
PsiBlast_PDB
95.37
42%
-105
- C5 -
2W6E
-
ATPA_BOVIN
A:
[67-544]
---------------
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
S
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
91
PsiBlast_CBE
95.32
42%
-104
- C5 -
1COW
3
ATPA_BOVIN
C:
[20-501]
-----------
D
T
S
V
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKKK
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
62
PsiBlast_CBE
95.19
42%
-104
- C5 -
1W0J
5
ATPA_BOVIN
C:
[20-501]
-----------
D
T
S
V
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
8
PsiBlast_PDB
95.06
42%
-105
- C5 -
2W6H
-
ATPA_BOVIN
A:
[24-501]
---------------
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
S
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
13
PsiBlast_PDB
95.01
42%
-105
- C5 -
1BMF
2
ATPA_BOVIN
A:
[24-501]
---------------
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------
33
PsiBlast_CBE
94.93
42%
-105
- C5 -
2JIZ
24
ATPA_BOVIN
J:
[20-501]
-----------
D
T
S
V
D
L
E
---
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
-
E
F
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
R
F
N
DGTDEKKK
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
--
S
H
-
V
I
S
Q
-
H
-
Q
A
L
L
S
K
I
R
T
D
G
K
I
S
E
E
S
D
A
K
L
K
E
I
V
--------