@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0092: (2016-03-12 )
MKKHTGTIISISGFVLRIEFNESELPEIGFALEYHTHQGTYLAEVVQHTGINTVSAIAIGEVSGLARGTEVVNLGHPIEVPVGETVQGRMLNVYGKAIDGKPEPAAEVKWPIFRAQPLLRELDTNKEILYTGIKVIDLICPILKGGKTGLFGGAGVGKSVLMQELINNISMLGGNSVFTGVGERVREGIGLYKELEASGVLPQTTVVLGQMNESPGVRMRVALTGLTIAEYLRDEEKKDVLLFIDNVFRFIQAGSEVSSLQGKIPITGGYQSTLSKEVGDFQDRIASTKNGSITSIQCVFLPADDIDDPSAVATFSHLDSTIVLERSIAALGIFPAVNPLQSFSRALNPTFVGERHYQLAVQVKFILQRYMELQEIINVLGMAELSDEDRKLVHRARKIRNFLSQPFYVSEKFTGTEGTFVEIEDLLGSIERILNGDYDERSERDFLFIGSYKDLK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170-.......180.......190.......200-----........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKH
T
G
T
I
I
S
I
S
G
F
V
L
R
I
EFNESELPE
I
G
F
A
L
E
Y
HTHQ
G
T
Y
L
A
E
V
V
Q
HTGI
N
T
V
S
A
I
A
I
G
E
V
SGLARG
T
E
V
V
NLGHPIEVPVGETVQG
R
M
L
N
V
Y
G
K
AIDGKPEPAAEVKWP
I
F
R
A
Q
P
L
L
R
E
LDTN
K
E
I
L
Y
T
G
I
K
V
I
D
L
I
C
P
I
LKGGKTGLFGGAGV
G
K
S
V
L
M
Q
E
L
I
N
N
I
S
ML-GGN
S
V
F
T
G
V
G
E
R
V
R
E
G
I
G
L
Y
K
E
L
EASGVL------PQ
T
T
V
V
L
GQMNESPG
V
R
M
R
V
A
LT
G
L
T
I
A
E
Y
L
R
D
E
EKK
D
V
L
L
F
I
D
N
V
F
R
F
I
QAGS
E
V
S
S
LQGKIPITGG
Y
Q
S
T
L
S
K
E
V
G
D
F
Q
D
R
I
ASTKNG
S
I
T
S
I
Q
C
V
F
L
PADDID
D
P
S
A
V
A
T
F
S
HLD
S
T
I
V
L
ER
S
I
A
A
LGIFPA
V
N
P
L
Q
S
F
S
R
ALNPTFVGE
R
H
Y
Q
L
A
V
Q
V
K
F
I
L
Q
R
Y
M
E
L
Q
E
I
I
N
V
LGMAELSD
E
D
R
K
L
V
H
R
A
R
K
I
R
N
F
L
SQ
P
F
Y
VSEKFTGTEG
T
F
V
E
I
E
D
L
L
G
S
I
E
R
I
LNGDYDERSER
D
F
L
F
IGSYKDLK
2
PsiBlast_PDB
98.49
52%
-96
- C7 -
2XOK
2
ATPB_YEAST
D:
[43-499]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
3
PsiBlast_PDB
98.00
52%
-93
- C7 -
2HLD
-
ATPB_YEAST
D:
[10-466]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
8
PsiBlast_PDB
97.54
52%
-93
- C7 -
3OEE
-
ATPB_YEAST
D:
[16-472]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
12
PsiBlast_PDB
97.25
52%
-94
- C7 -
3OEH
-
ATPB_YEAST
D:
[16-472]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
F
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
17
PsiBlast_PDB
97.10
51%
-94
- C7 -
1COW
2
ATPB_BOVIN
D:
[14-469]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
5
PsiBlast_PDB
97.00
52%
-96
- C7 -
3ZRY
2
ATPB_YEAST
D:
[10-466]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
148
PsiBlast_CBE
96.91
51%
-92
- C7 -
4TT3
3
ATPB_BOVIN
F:
[12-467]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
137
PsiBlast_CBE
96.87
51%
-93
- C7 -
1E1R
4
ATPB_BOVIN
D:
[14-469]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
23
PsiBlast_CBE
96.85
52%
-94
- C7 -
2XOK
4
ATPB_YEAST
F:
[43-499]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
7
PsiBlast_PDB
96.69
52%
-93
- C7 -
3OE7
-
ATPB_YEAST
D:
[16-472]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
24
PsiBlast_CBE
96.63
52%
-93
- C7 -
3ZRY
3
ATPB_YEAST
F:
[10-466]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
138
PsiBlast_CBE
96.46
51%
-93
- C7 -
1E1Q
3
ATPB_BOVIN
F:
[14-469]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
130
PsiBlast_CBE
96.45
51%
-93
- C7 -
1H8E
4
ATPB_BOVIN
D:
[14-469]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
91
PsiBlast_CBE
96.36
51%
-94
- C7 -
2V7Q
3
ATPB_BOVIN
D:
[14-469]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
4
PsiBlast_PDB
96.28
52%
-90
- C7 -
2WPD
2
ATPB_YEAST
D:
[10-466]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
140
PsiBlast_CBE
96.25
51%
-93
- C7 -
1E1Q
2
ATPB_BOVIN
D:
[14-469]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
109
PsiBlast_CBE
96.23
51%
-94
- C7 -
2JIZ
2
ATPB_BOVIN
D:
[14-469]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
30
PsiBlast_CBE
96.21
52%
-90
- C7 -
3ZIA
1
ATPB_YEAST
E:
[10-466]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-
97
PsiBlast_CBE
96.11
51%
-94
- C7 -
2JJ2
2
ATPB_BOVIN
D:
[14-469]
----
T
G
R
I
V
A
V
I
G
A
V
V
D
V
Q
F
D
E
G
-
L
P
P
I
L
N
A
L
E
V
Q
G
R
E
T
R
L
V
L
E
V
A
Q
H
L
G
E
S
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
Q
K
V
L
D
S
G
A
P
I
R
I
P
V
G
P
E
T
L
G
R
I
M
N
V
I
G
E
P
I
D
E
R
G
P
I
K
T
K
Q
F
A
A
I
H
A
E
A
P
E
F
V
E
M
S
V
E
Q
E
I
L
V
T
G
I
K
V
V
D
L
L
A
P
Y
A
K
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
L
I
M
E
L
I
N
N
V
A
K
A
H
G
G
Y
S
V
F
A
G
V
G
E
R
T
R
E
G
N
D
L
Y
H
E
M
I
E
S
G
V
I
NLKDAT
S
K
V
A
L
V
Y
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
V
A
E
Y
F
R
D
Q
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
T
M
Q
E
R
I
T
T
T
K
K
G
S
I
T
S
V
Q
A
I
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
A
I
A
E
L
G
I
Y
P
A
V
D
P
L
D
S
T
S
R
I
M
D
P
N
I
V
G
S
E
H
Y
D
V
A
R
G
V
Q
K
I
L
Q
D
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
E
D
K
L
T
V
S
R
A
R
K
I
Q
R
F
L
S
Q
P
F
Q
V
A
E
V
F
T
G
H
L
G
K
L
V
P
L
K
E
T
I
K
G
F
Q
Q
I
L
A
G
E
Y
D
H
L
P
E
Q
A
F
Y
M
V
G
P
I
E
E
--
10
PsiBlast_PDB
96.05
52%
-90
- C7 -
4B2Q
-
ATPB_YEAST
D:
[5-461]
----
T
G
K
V
T
A
V
I
G
A
I
V
D
V
H
F
E
Q
S
E
L
P
A
I
L
N
A
L
E
I
K
T
P
Q
G
K
L
V
L
E
V
A
Q
H
L
G
E
N
T
V
R
T
I
A
M
D
G
T
E
G
L
V
R
G
E
K
V
L
D
T
G
G
P
I
S
V
P
V
G
R
E
T
L
G
R
I
I
N
V
I
G
E
P
I
D
E
R
G
P
I
K
S
K
L
R
K
P
I
H
A
D
P
P
S
F
A
E
Q
S
T
S
A
E
I
L
E
T
G
I
K
V
V
D
L
L
A
P
Y
A
R
G
G
K
I
G
L
F
G
G
A
G
V
G
K
T
V
F
I
Q
E
L
I
N
N
I
A
K
A
H
G
G
F
S
V
F
T
G
V
G
E
R
T
R
E
G
N
D
L
Y
R
E
M
K
E
T
G
V
I
NLEGE-
S
K
V
A
L
V
F
G
Q
M
N
E
P
P
G
A
R
A
R
V
A
L
T
G
L
T
I
A
E
Y
F
R
D
E
E
G
Q
D
V
L
L
F
I
D
N
I
F
R
F
T
Q
A
G
S
E
V
S
A
L
L
G
R
I
P
S
A
V
G
Y
Q
P
T
L
A
T
D
M
G
L
L
Q
E
R
I
T
T
T
K
K
G
S
V
T
S
V
Q
A
V
Y
V
P
A
D
D
L
T
D
P
A
P
A
T
T
F
A
H
L
D
A
T
T
V
L
S
R
G
I
S
E
L
G
I
Y
P
A
V
D
P
L
D
S
K
S
R
L
L
D
A
A
V
V
G
Q
E
H
Y
D
V
A
S
K
V
Q
E
T
L
Q
T
Y
K
S
L
Q
D
I
I
A
I
L
G
M
D
E
L
S
E
Q
D
K
L
T
V
E
R
A
R
K
I
Q
R
F
L
S
Q
P
F
A
V
A
E
V
F
T
G
I
P
G
K
L
V
R
L
K
D
T
V
A
S
F
K
A
V
L
E
G
K
Y
D
N
I
P
E
H
A
F
Y
M
V
G
G
I
E
D
V
-