@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0108: (2016-03-12 )
MESMKWIWQYVRKYRLLMIGVFILIFIASGISIIYPLLGGKVIDDVVYQNKTNLLIPLLLIMIISTIIRTICRYTYQIMCERIGQNSLFRIREDLYKKLQSLDFDFFNNTRVGDIMARMTGDTDAIRHFVSWVSYNILENVFLFSFAIIIMATIDWKLTLALVIVTPLIAVLTMKMSSKAQPVFYEIRESFSRLNSMVEENISGNRVVKAFAREDFEMKKFHEHNEDFKKRNLDSADVSRTYLPVLDSLAGMLVVITLIFGGYLVIKGQMTLGDLVAFNGFLWMLNGPMRMSGWLINDVQRFIASSFKIQDMMVTDAKIPIHAEKPAPSLQGHVEFKNVSFHFEDDPNTDVLKNISLKASPGQTIAILGETGAGKSTLVNLICRFYDPTSGEILIDGVDARKWHVRELRNHIATVMQDIFLFSDTIEGNIAFGAPDATMEDVRRMARIADADHFIETMPESYDTIVGERGVGLSGGQKQRISLARALLKNPSILILDDTTSAVDMETEVKIQGELKKITENTTTFIIAHRISSVKEADEILILNHGEIIERGTHTSLLAEKGYYFDIYNKQLGTEANVNG
Atome Classification :
(39 SA)
.........10....--.-...20........30--.........--40-----........50--.--------.......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260........270.......280.......290.......300.......310.--......320-.-----.-----...----------.------.330.......340.......350--........360.......370.......380.......---390......--.400........410.......420..-.....430.-...---.---..440.......450.....-..460.......--470.......480.......490.......500.......510........--520.....-....530....-...540.......550.......560.........570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
S
M
K
W
I
W
Q
Y
V
R
K
Y
R
--
L
-
L
M
I
G
V
F
I
L
I
F
I
AS
G
---
I
S
I
I
Y
P
LLG--
G
K
-----
V
I
D
D
V
V
YQNK--T--------
N
L
L
I
P
L
L
L
I
M
I
I
S
T
I
I
R
T
I
C
R
Y
T
Y
Q
I
M
C
E
RIGQ
N
S
L
F
R
I
R
E
D
L
Y
K
K
L
Q
SLDFDFFNNT
R
V
G
D
I
M
A
R
MTG
D
T
D
A
I
R
H
F
V
S
W
V
S
Y
N
I
L
E
N
V
F
L
F
S
F
A
I
I
I
M
A
TID
W
K
L
T
L
A
L
V
I
V
T
P
L
I
A
V
L
T
M
K
MSSKAQ
P
V
F
Y
E
I
R
E
S
F
S
R
L
N
S
M
V
E
ENISG
N
R
V
V
K
A
F
A
RED
F
E
M
K
K
F
H
EH
N
E
D
F
K
KRNL
D
S
A
D
VS
R
T
Y
L
P
V
L
D
S
L
A
G
M
L
V
V
I
T
L
I
F-G
G
Y
L
V
I
KGQMT
L
G
D
L
V
A
FN
G
F
L
W
MLNGPMRM
S
G
W
L
I
N
D
V
Q
R
F
I
A
SS
F
K
I
Q
D
M
M
--VTDAKI
P
I
H-A-----E-----KPA----------P------SLQ
G
H
V
E
FK
N
V
S
F
H
FEDDPN
T
D
-
V
--
L
K
N
I
S
L
KASPG
Q
T
I
A
I
L
GETGA
G
K
S
T
L
V
N
L
I
C
R
FYDPT---SG
E
I
L
I
DGV--DA
R
-
K
W
H
V
R
E
L
R
N
H
I
A
T
V
M
Q
D
I
F
L
FSD-TIEG
N
I
AFG-APD---A---
T
M
E
D
V
R
R
M
A
R
I
A
D
A
D
H
F
I
E
T-MP
E
S
Y
D
T
I
VGER--GVGLSGG
Q
K
Q
R
I
S
L
A
R
A
L
LKNP
S
I
L
I
LDDTTSAVD
M
E
T
E
V
K
I
-
Q
G
E
L
K
K
IT--E--NT
T
T
F
-
I
I
A
H
R
I
S
S
VKE-A
D
E
I
L
I
LNH
G
E
I
IERGTH
T
S
L
LAE--K
G
Y
Y
F
D
I
YNKQLGTEANVNG
6
PsiBlast_PDB
89.15
35%
-109
- C2 -
2ONJ
4
Y1866_STAAM
A:
[2-576]
---
I
K
R
Y
L
Q
F
V
K
P
Y
K
--
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
---
I
P
M
L
I
P
L
L
I
--
K
Y
-----
A
I
D
G
V
I
N
N
H
A
--
L
T
T
D
E
K
V
H
-
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
-
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
--
D
E
D
Y
D
I
K
N
G
V
G
-----
A
-----
Q
P
I
----------
E
------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
P
-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
--
N
I
K
-
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
-
R
P
T
---
A
---
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
Q
G
Y
D
T
E
V
G
E
R
--
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
-
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
---------
21
PsiBlast_CBE
89.13
35%
-109
- C2 -
2ONJ
4
Y1866_STAAM
B:
[2-576]
---
I
K
R
Y
L
Q
F
V
K
P
Y
K
--
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
---
I
P
M
L
I
P
L
L
I
--
K
Y
-----
A
I
D
G
V
I
N
N
H
A
--
L
TTDEKVH-
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
-
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
--
D
E
D
Y
D
I
K
N
G
V
G
-----
A
-----
Q
P
I
----------
E
------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
P
-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
--
N
I
K
-
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
-
R
P
T
---
A
---
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
Q
G
Y
D
T
E
V
G
E
R
--
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
-
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
---------
5
PsiBlast_PDB
89.00
35%
-108
- C2 -
2HYD
3
Y1866_STAAM
A:
[2-576]
---
I
K
R
Y
L
Q
F
V
K
P
Y
K
--
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
---
I
P
M
L
I
P
L
L
I
--
K
Y
-----
A
I
D
G
V
I
N
N
H
A
--
L
T
T
D
E
K
V
H
-
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
-
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
--
D
E
D
Y
D
I
K
N
G
V
G
-----
A
-----
Q
P
I
----------
E
------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
P
-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
--
N
I
K
-
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
-
R
P
T
---
A
---
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
Q
G
Y
D
T
E
V
G
E
R
--
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
-
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
---------
22
PsiBlast_CBE
88.21
35%
-108
- C2 -
2HYD
3
Y1866_STAAM
B:
[2-576]
---
I
K
R
Y
L
Q
F
V
K
P
Y
K
--
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
---
I
P
M
L
I
P
L
L
I
--
K
Y
-----
A
I
D
G
V
I
N
N
H
A
--
L
TTDEKVH-
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
-
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
--
D
E
D
Y
D
I
K
N
G
V
G
-----
A
-----
Q
P
I
----------
E
------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
P
-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
--
N
I
K
-
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
-
R
P
T
---
A
---
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
Q
G
Y
D
T
E
V
G
E
R
--
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
-
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
---------
23
PsiBlast_CBE
87.28
32%
-114
- C2 -
4Q4A
2
?
A:
[12-579]
----
K
T
L
A
R
Y
L
K
P
Y
W
--
I
-
F
A
V
L
A
P
L
F
M
V
V
E
V
I
---
C
D
L
S
Q
P
T
L
L
--
A
R
-----
I
V
D
E
G
I
A
R
G
D
--
F
--------
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
-
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
------------
N
-----
E
-----
K
P
A
I
E
E
A
DN
A
L
A
L
P
------
N
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
--
N
T
D
P
V
--
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
--
D
V
R
-
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
L
K
W
G
-
R
E
D
---
A
---
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
-
L
P
E
G
Y
D
S
R
V
E
R
G
--
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
-
L
D
G
L
K
R
Y
T
--
K
--
G
C
T
T
F
-
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------
3
PsiBlast_PDB
86.58
34%
-117
- C2 -
4Q4H
-
Y288_THEMA
B:
[24-592]
--
T
L
R
R
L
L
G
Y
L
R
P
H
T
--
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
---
L
G
V
L
S
P
Y
L
I
--
G
K
-----
T
I
D
V
V
F
V
P
R
R
--
F
--------
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
-
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
--------
D
L
E
-
E
-----
E
-----
K
D
D
----------
P
DAVELR
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
--
D
I
R
-
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
K
Y
G
-
N
P
G
---
A
---
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
-
L
P
E
G
Y
E
T
V
L
T
D
N
--
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
-
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
-
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------
1
PsiBlast_PDB
86.44
34%
-120
- C2 -
3QF4
1
Y288_THEMA
B:
[24-592]
--
T
L
R
R
L
L
G
Y
L
R
P
H
T
--
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
---
L
G
V
L
S
P
Y
L
I
--
G
K
-----
T
I
D
V
V
F
V
P
R
R
--
F
--------
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
-
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
--------
D
L
E
-
E
-----
E
-----
K
D
D
----------
P
DAVELR
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
--
D
I
R
-
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
K
Y
G
-
N
P
G
---
A
---
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
-
L
P
E
G
Y
E
T
V
L
T
D
N
--
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
-
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
-
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------
2
PsiBlast_PDB
86.35
34%
-122
- C2 -
4Q4A
1
Y288_THEMA
B:
[24-592]
--
T
L
R
R
L
L
G
Y
L
R
P
H
T
--
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
---
L
G
V
L
S
P
Y
L
I
--
G
K
-----
T
I
D
V
V
F
V
P
R
R
--
F
--------
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
-
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
--------
D
L
E
-
E
-----
E
-----
K
D
D
----------
P
DAVELR
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
--
D
I
R
-
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
K
Y
G
-
N
P
G
---
A
---
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
-
L
P
E
G
Y
E
T
V
L
T
D
N
--
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
-
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
-
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------
24
PsiBlast_CBE
85.61
32%
-114
- C2 -
3QF4
2
?
A:
[12-579]
----
K
T
L
A
R
Y
L
K
P
Y
W
--
I
-
F
A
V
L
A
P
L
F
M
V
V
E
V
I
---
C
D
L
S
Q
P
T
L
L
--
A
R
-----
I
V
D
E
G
I
A
R
G
D
--
F
--------
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
-
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
------------
N
-----
E
-----
K
P
A
I
E
E
A
DN
A
L
A
L
P
------
N
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
--
N
T
D
P
V
--
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
--
D
V
R
-
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
L
K
W
G
-
R
E
D
---
A
---
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
-
L
P
E
G
Y
D
S
R
V
E
R
G
--
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
-
L
D
G
L
K
R
Y
T
--
K
--
G
C
T
T
F
-
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------
4
PsiBlast_PDB
84.87
33%
-119
- C2 -
4Q4J
-
Y288_THEMA
B:
[24-592]
--
T
L
R
R
L
L
G
Y
L
R
P
H
T
--
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
---
L
G
V
L
S
P
Y
L
I
--
G
K
-----
T
I
D
V
V
F
V
P
R
R
--
F
--------
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
-
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
--------
D
L
E
-
E
-----
E
-----
K
D
D
----------
P
DAVELR
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
--
D
I
R
-
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
K
Y
G
-
N
P
G
---
A
---
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
-
L
P
E
G
Y
E
T
V
L
T
D
N
--
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
-
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
-
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------
105
HHSearch
78.40
30%
-107
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[4-572]
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
--
R
-
R
L
A
A
A
V
G
F
L
T
M
S
S
V
---
I
S
M
S
A
P
F
F
L
--
G
K
-----
I
I
D
V
I
Y
T
N
P
T
--
V
DY
S
-----
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
-
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
--
E
R
E
P
K
L
P
F
N
-
E
-----
G
V
I
---
L
N
E
----------
K
------
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
-
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
--
D
I
R
-
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
-
A
D
D
PSS
V
---
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
-
F
P
Q
G
F
N
T
V
V
G
E
K
--
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
-
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P---------------------
11
PsiBlast_PDB
76.89
31%
-109
- C2 -
4AYX
7
ABCBA_HUMAN
A:
[30-574]
-----------------------------
M
S
S
V
---
I
S
M
S
A
P
F
F
L
--
G
K
-----
I
I
D
-
V
I
Y
T
N
P
--
T
VDY
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
----
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
-
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
--
E
R
E
P
K
L
P
F
N
-
E
G
V
I
L
N
E
-----
K
-------------------
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
-
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
--
D
I
R
-
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
-
A
D
D
---
P
SSV
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
-
F
P
Q
G
F
N
T
V
V
G
E
K
--
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
-
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-
N
G
------------------
15
PsiBlast_PDB
76.79
28%
-105
- C2 -
3B60
2
MSBA_SALTY
A:
[11-581]
-
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
-
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
------------
D
D
G
F
G
K
T
D
--
R
--------
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
-
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
--
D
S
E
Q
E
K
D
-
E
-
G
-----
K
-----
R
V
I
----------
D
------
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
---
P
G
R
E
-
V
PA
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
--
D
L
R
-
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
---
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
-
M
D
N
G
L
D
T
I
I
G
E
N
--
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
-
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
-
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------
107
HHSearch
76.54
27%
-104
- C2 -
3WMG
6
?
A:
[16-598]
-----
R
I
F
A
L
A
W
S
S
S
--
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
---
T
L
P
A
F
A
I
V
F
--
G
R
-----
M
F
Q
V
F
T
K
S
K
S
Q
I
E
--------
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
-
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
--
D
R
V
P
Q
Y
R
R
P
-
D
-----
P
G
A
E
V
V
T
Q
P
----------
L
------
V
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
P
T
R
M
N
V
E
-
V
--
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
--
P
A
W
-
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
-
T
I
R
D
N
I
L
Y
G
-
K
R
D
---
A
---
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
-
L
P
D
G
L
D
T
E
V
G
E
R
--
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
-
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
-
V
I
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
------
106
HHSearch
76.12
28%
-105
- C2 -
3B60
2
MSBA_SALTY
A:
[13-581]
---
F
R
R
L
W
P
T
I
A
P
F
K
--
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
---
S
D
T
F
M
L
S
L
L
--
K
P
-----
L
L
D
D
G
F
G
K
T
D
--
R
--------
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
-
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
--
D
S
E
Q
E
K
D
E
G
-
K
-----------
R
V
I
----------
D
------
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
E
-
V
P
-
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
--
D
L
R
-
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
A
-
R
T
E
E--
Y
---
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
-
M
D
N
G
L
D
T
I
I
G
E
N
--
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
-
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
-
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------
125
Fugue
75.27
28%
-105
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
--
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
---
S
D
T
F
M
L
S
L
L
--
K
P
-----
L
L
D
D
G
F
G
K
T
D
--
R
--------
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
-
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
--
D
S
E
Q
E
K
D
-
E
-
G
-----
K
-----
R
V
I
----------
D
------
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
E
V
P
-
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
--
D
L
R
-
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
A
-
R
T
E
---
E
Y--
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
-
M
D
N
G
L
D
T
I
I
G
E
N
--
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
-
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
-
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------
12
PsiBlast_PDB
74.95
31%
-106
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[30-572]
-----------------------------
M
S
S
V
---
I
S
M
S
A
P
F
F
L
--
G
K
-----
I
I
D
-
V
I
Y
T
N
P
--
T
VDY
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
----
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
-
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
--
E
R
E
P
K
L
P
F
N
-
E
G
V
I
L
N
E
-----
K
-------------------
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
-
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
--
D
I
R
-
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
-
A
D
D
---
P
SSV
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
-
F
P
Q
G
F
N
T
V
V
G
E
K
--
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
-
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P---------------------
16
PsiBlast_PDB
74.03
31%
-112
- C2 -
4AYW
3
ABCBA_HUMAN
A:
[61-598]
-----------------------------
M
S
S
V
---
I
S
M
S
A
P
F
F
L
--
G
K
-----
I
I
D
-
V
I
Y
T
N
P
--
T
VD
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
----
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
-
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
--
E
R
E
P
K
L
P
F
N
-
E
G
V
I
L
N
E
-----
K
-------------------
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
-
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
--
D
I
R
-
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
-
A
D
D
---
P
SSV
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
-
F
P
Q
G
F
N
T
V
V
G
E
K
--
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
-
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
--------------------------
10
PsiBlast_PDB
73.54
31%
-104
- C2 -
4AYT
8
ABCBA_HUMAN
A:
[30-567]
-----------------------------
M
S
S
V
---
I
S
M
S
A
P
F
F
L
--
G
K
-----
I
I
D
-
V
I
Y
T
N
P
--
T
VDY
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
----
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
-
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
--
E
R
E
P
K
L
P
F
N
-
E
G
V
I
L
N
E
-----
K
-------------------
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
-
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
--
D
I
R
-
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
-
A
D
D
---
P
SSV
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
-
F
P
Q
G
F
N
T
V
V
G
E
K
--
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
-
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
--------------------------
7
PsiBlast_PDB
73.43
35%
-107
- C2 -
4A82
-
Y1866_STAAM
A:
[2-576]
---
I
K
R
Y
L
Q
F
V
K
P
Y
K
--
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
---
I
P
M
L
I
P
L
L
I
--
K
Y
-----
A
I
D
G
V
I
N
N
H
A
--
L
T
T
D
E
K
V
H
-
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
-
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
--
D
E
D
Y
D
I
K
N
G
V
G
-----
A
-----
Q
P
I
----------
E
------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
P
-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
--
N
I
K
-
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
-
R
P
T
---
A
---
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
Q
G
Y
D
T
E
V
G
E
R
--
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
-
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
---------
25
PsiBlast_CBE
72.04
31%
-97
- C2 -
4S0F
2
?
B:
[173-725]
-------------------------
L
C
I
F
L
A
S
------
L
L
Y
T
A
L
G
IA
G
S
FYIKF
L
F
D
D
L
I
K
F
E
K
--
L
--------
N
D
L
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
-
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
EL
A
T
E
K
E
L
R
E
D
-
S
-----
D
-----
D
F
V
----------
I
------
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
L
R
K
P
-
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
--
S
I
K
-
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
-
T
V
K
E
N
L
C
L
G
-
N
E
N
---
V
---
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
-
L
P
L
K
Y
D
T
F
L
N
E
S
--
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
-
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
-
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
G
C
Y
F
K
M
W
K
Q
T
E
--------
18
PsiBlast_PDB
71.33
31%
-96
- C2 -
4S0F
2
?
A:
[173-725]
-------------------------
L
C
I
F
L
A
S
------
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
--
L
--------
N
D
L
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
-
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
R
E
D
-
S
-----
D
-----
D
F
V
----------
I
------
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
L
R
K
P
-
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
--
S
I
K
-
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
-
T
V
K
E
N
L
C
L
G
-
N
E
N
---
V
---
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
-
L
P
L
K
Y
D
T
F
L
N
E
S
--
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
-
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
-
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
G
C
Y
F
K
M
W
K
Q
T
E
--------
31
PsiBlast_CBE
54.80
46%
-95
- C2 -
3NH9
3
A:
[51-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
R
I
E
F
E
N
V
H
F
S
Y
A
D
G
R
E
T
-----
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
--
D
I
S
-
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
-
R
V
T
---
A
---
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
-
F
P
E
G
Y
R
T
Q
V
G
E
R
--
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
-
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
-
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
------
29
PsiBlast_CBE
53.90
46%
-95
- C2 -
3NHB
3
A:
[51-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
R
I
E
F
E
N
V
H
F
S
Y
A
D
-
R
E
T
-----
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
--
D
I
S
-
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
-
R
V
T
---
A
---
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
-
F
P
E
G
Y
R
T
Q
V
G
E
R
--
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
-
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
-
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
------
30
PsiBlast_CBE
53.68
46%
-95
- C2 -
3NHA
4
A:
[51-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
R
I
E
F
E
N
V
H
F
S
Y
A
D
-
R
E
T
-----
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
--
D
I
S
-
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
-
R
V
T
---
A
---
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
-
F
P
E
G
Y
R
T
Q
V
G
E
R
--
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
-
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
-
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
------
33
PsiBlast_CBE
52.88
41%
-104
- C2 -
5DGX
1
?
A:
[10-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
----------
A
------
K
V
D
G
N
V
T
I
K
D
L
S
F
A
F
G
E
H
K
----
V
--
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
--
D
T
R
-
E
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
-
T
V
Y
N
N
I
A
F
G
---
E
---
V
---
S
E
E
E
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
-
L
S
D
G
I
N
T
N
I
G
N
N
--
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
-----------------
L
E
S
L
T
--
K
--
S
C
T
T
I
-
V
I
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
G
L
Y
T
R
L
Y
Q
S
G
L
--------
44
PsiBlast_CBE
51.21
45%
-102
- C2 -
2FGK
2
HLYBP_ECOLX
A:
[8-233]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
--
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
--
D
L
A
-
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
P
G
---
M
---
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
-
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
----------------------
41
PsiBlast_CBE
50.72
45%
-104
- C2 -
2FGK
2
D:
[8-233]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
--
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
--
D
L
A
-
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
P
G
---
M
---
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
-
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
----------------------
65
PsiBlast_CBE
50.71
38%
-86
- C2 -
2IXF
4
TAP1_RAT
B:
[9-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
P
L-----
N
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
N
V
Q
-
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
--
P
L
V
-
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
I
A
Y
G
L
T
R
T
---
P
---
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
-
F
P
Q
G
Y
D
T
E
V
G
E
T
--
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
-
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
-
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
----------------
66
PsiBlast_CBE
50.49
38%
-86
- C2 -
2IXF
5
TAP1_RAT
A:
[9-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
P
L-----
N
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
N
V
Q
-
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
--
P
L
V
-
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
I
A
Y
G
L
T
R
T
---
P
---
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
-
F
P
Q
G
Y
D
T
E
V
G
E
T
--
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
-
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
-
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
----------------
42
PsiBlast_CBE
50.21
45%
-103
- C2 -
2FGK
2
HLYBP_ECOLX
C:
[8-233]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
--
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
--
D
L
A
-
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
P
G
---
M
---
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
-
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
----------------------
43
PsiBlast_CBE
50.14
45%
-103
- C2 -
2FGK
2
HLYBP_ECOLX
B:
[8-233]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
--
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
--
D
L
A
-
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
P
G
---
M
---
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
-
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
-
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
----------------------
62
PsiBlast_CBE
49.33
38%
-87
- C2 -
1JJ7
2
A:
[11-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
R
P
D
V
L
-
V
--
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
--
P
L
P
-
Q
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
-
S
L
Q
E
N
I
A
Y
G
L
T
Q
K
---
P
---
T
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
-
L
P
Q
G
Y
D
T
E
V
D
E
A
--
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
-
E
Q
L
L
Y
E
S
P
--
E
RY
S
R
S
V
L
-
L
I
T
Q
H
L
S
L
V
E
Q
-
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
G
C
Y
W
---------------
100
PsiBlast_CBE
34.49
31%
-87
- C2 -
2PZF
3
CFTR_HUMAN
A:
[15-217]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
W
--
G
G
T
P
-
V
--
L
K
D
I
N
F
K
I
E
R
G
Q
L
L
A
V
A
G
S
T
G
A
G
K
T
S
L
L
M
M
I
M
G
E
L
E
P
S
---
E
G
K
I
K
H
S
G
----------------
R
I
S
F
C
S
Q
F
S
W
I
M
P
G
-
T
I
K
E
N
I
I
G
V
-
S
Y
D
---
E
---
Y
R
--
Y
R
S
V
I
K
A
C
Q
L
E
E
D
I
S
K
-
F
A
E
K
D
N
I
V
L
G
E
G
--
G
I
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
L
T
E
K
E
I
F
E
S
C
V
C
K
L
M
--
A
--
N
K
T
R
I
-
L
V
T
S
K
M
E
H
L
K
K
-
A
D
K
I
L
I
L
H
E
G
S
S
Y
F
Y
G
T
F
S
E
L
-------------------------
102
PsiBlast_CBE
33.13
31%
-95
- C2 -
2BBT
2
CFTR_HUMAN
A:
[51-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
-
V
--
L
K
D
I
N
F
K
I
E
R
G
Q
L
L
A
V
A
G
S
T
G
A
G
K
T
S
L
L
M
M
I
M
G
E
L
E
P
S
---
E
G
K
I
K
H
S
G
----------------
R
I
S
F
C
S
Q
N
S
W
I
M
P
G
-
T
I
K
E
N
I
I
G
V
-
S
Y
D
---
E
---
Y
R
--
Y
R
S
V
I
K
A
C
Q
L
E
E
D
I
S
K
-
F
A
E
K
D
N
I
V
L
G
----
G
I
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
L
T
E
K
E
I
F
E
S
C
V
C
K
L
M
--
A
--
N
K
T
R
I
-
L
V
T
S
K
M
E
H
L
K
K
-
A
D
K
I
L
I
L
H
E
G
S
S
Y
F
Y
G
T
F
S
E
L
-------------------------
84
PsiBlast_CBE
30.52
32%
-75
- C2 -
4U00
3
?
A:
[19-220]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
---
E
G
E
V
V
V
D
G
L
--
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
--------
A
---
P
M
R
-
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
-
L
-
E
R
V
G
I
L
D
Q
A
R
KY
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A
--
Q
--
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
------------------------------
79
PsiBlast_CBE
30.35
31%
-72
- C2 -
4YMU
2
?
A:
[15-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
KI
N
N
G
-
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
--
A
P
V
---
K
---
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
----
Q
Y
--
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
N
-
E
--
G
M
T
M
V
-
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
-----------------------------
78
PsiBlast_CBE
30.07
31%
-70
- C2 -
4YMU
2
?
J:
[15-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
KI
N
N
G
-
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
--
A
P
V
---
K
---
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
----
Q
Y
--
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
N-
E
--
G
M
T
M
V
-
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
-----------------------------
77
PsiBlast_CBE
27.83
31%
-68
- C2 -
4YMV
1
?
A:
[15-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
KI
N
N
G
-
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
--
A
P
V
---
K
---
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
----
Q
Y
--
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
N
-
E
--
G
M
T
M
V
-
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
-----------------------------