@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0110: (2016-03-12 )
MDYEKALAFIKSNSTLEQEEGTEVIFKQAQETARGNLDPFLLKDLKQHLGGTNDAIKEAPQEIQMPDFSNLEIATAAALQMRATMGSPNIDLSNGVTTEYRVVEGDYGDIPVRIYRHEEATKPVPAFIFYHGGGFVGGTPAVVENFCKGIAEKLPAVVINVDYHLAPEFPAPAAPKDCYRVLEWVVEQSNELGIDASKIGVSGDSAGGTLAAAVSYMDYEAETNYVGFQALLYPALTLVDEDNDKYQWDISKFGASEDTLPLVAPGIIGMNSSGELLRKAYVRDENPAAPIYSPLSAVDKSIYPPTLIASAEFDALRAFADVFAKELRASGVQTKAIVYQGMCHAFIDKYGIFPQAEDVADEIVQMMKEIF
Atome Classification :
(21 SA)
.........10........20........30.........40.....-...50........60........70........80........--90-----.---.-.-......100....-..--.110.......120.......130.......140-........150...-....160....----...170.......180.......190.......200.......210.......220.--......230.......240....-...250.......260.......270.......280------....------.-.------...290.......--.300.......310.......320.......330.......340.......350.---....-...360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
Y
E
K
A
L
A
F
IKSNSTLEQEE
G
T
E
V
I
F
K
Q
A
Q
-
E
TARGNL
D
P
F
L
L
K
D
L
K
-
Q
HLGGT
N
D
A
I
K
EA
P
Q
EIQMPDFSN
L
E
I
A
T
A
A
A
L
Q
M
R
ATMGSPN--I------D---L-S-NGV
T
T
E
Y
R
V
VEGD-YG--DI
P
V
R
I
Y
RHEEATKPV
P
A
F
I
F
YHGGGFVGG
T
P
A
--
V
V
E
N
F
C
K
G
I
A
E
KL
P
-
A
V
V
I
N
V
D
Y
HLA----PEFPAPAA
P
K
D
C
Y
R
V
L
E
W
V
V
E
QSNELGI
D
A
S
KIGVSGDSAG
G
T
L
A
A
A
V
S
Y
M
DYEAET--N
Y
V
G
F
Q
A
L
L
Y
P
A
L
T
L
VDEDND
K
Y
-
Q
W
D
I
S
KFGASEDT
L
P
L
VAPGIIGMNS
S
G
E
L
L
R
K
A
--------
Y
VRD------E-N------PAAPI-Y
S
P
L
S
A
V--DKSIYPPTLIAS
A
E
F
D
A
L
R
A
F
A
D
V
F
A
K
E
L
R
ASGV
Q
T
K
A
I
V
Y
Q
G
M
C
H
A
F
I
D
KY-GI---FP
Q
A
-
E
D
V
A
D
E
I
V
Q
M
M
K
E
IF
23
PsiBlast_CBE
86.76
36%
-104
- C1 -
1JJI
1
?
B:
[56-308]
----------------------------------------------------------------------------------------------------------------
V
E
D
R
T
I
K
G
R
-
N
G
--
D
I
R
V
R
V
Y
Q
Q
K
P
D
S
---
P
V
L
V
Y
Y
H
G
G
G
F
V
I
C
S
I
E
--
S
H
D
A
L
C
R
R
I
A
R
L
S
N
-
S
T
V
V
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
Y
D
C
Y
D
A
T
K
W
V
A
E
N
A
E
E
L
R
I
D
P
S
K
I
F
V
G
G
D
S
A
G
G
N
L
A
A
A
V
S
I
M
A
R
D
S
G
E
--
D
F
I
K
H
Q
I
L
I
Y
P
V
V
N
F
V
A
P
T
P
------
S
L
L
E
F
G
---
E
G
L
W
I
L
D
Q
K
I
M
S
W
F
S
E
-----
Q
Y
--------
F
S
R
E
------
E
-
D
------
K
F
N
P
L
-
A
S
V
I
F
A
---
D
L
E
N
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
E
G
E
V
F
G
Q
M
L
R
R
A
G
V
E
A
S
I
V
R
Y
R
G
V
L
H
G
F
I
N
Y
Y
-
P
V
---
L
K
A
A
-
R
D
A
I
N
Q
I
A
A
L
L
----
45
HHSearch
85.82
36%
-103
- C1 -
1JJI
1
?
A:
[52-310]
------------------------------------------------------------------------------------------------------------
R
V
E
R
V
E
D
R
T
I
K
G
R
-
N
G
--
D
I
R
V
R
V
Y
Q
Q
K
P
---
D
S
P
V
L
V
Y
Y
H
G
G
G
F
V
I
C
S
I
E
--
S
H
D
A
L
C
R
R
I
A
R
L
S
N
-
S
T
V
V
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
Y
D
C
Y
D
A
T
K
W
V
A
E
N
A
E
E
L
R
I
D
P
S
K
I
F
V
G
G
D
S
A
G
G
N
L
A
A
A
V
S
I
M
A
R
D
S
G
E
--
D
F
I
K
H
Q
I
L
I
Y
P
V
V
N
F
V
A
P
T
P
------
S
L
L
E
F
G
E
G
L
-----
W
--
I
L
D
Q
-
K
-
I
M
S
W
F
S
E
Q
--------
Y
F
S
R
E-----
E
-
D
------
K
F
N
P
L
-
A
S
V
I
F
A
D
---
L
E
N
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
E
G
E
V
F
G
Q
M
L
R
R
A
G
V
E
A
S
I
V
R
Y
R
G
V
L
H
G
F
I
N
Y
Y
-
P
V
---
L
K
A
A
-
R
D
A
I
N
Q
I
A
A
L
L
V
F
--
1
PsiBlast_PDB
85.00
36%
-105
- C1 -
1JJI
1
?
A:
[56-308]
----------------------------------------------------------------------------------------------------------------
V
E
D
R
T
I
K
G
R
-
N
G
--
D
I
R
V
R
V
Y
Q
Q
K
P
D
S
---
P
V
L
V
Y
Y
H
G
G
G
F
V
I
C
S
I
E
--
S
H
D
A
L
C
R
R
I
A
R
L
S
N
-
S
T
V
V
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
Y
D
C
Y
D
A
T
K
W
V
A
E
N
A
E
E
L
R
I
D
P
S
K
I
F
V
G
G
D
S
A
G
G
N
L
A
A
A
V
S
I
M
A
R
D
S
G
E
--
D
F
I
K
H
Q
I
L
I
Y
P
V
V
N
F
V
A
P
T
P
------
S
L
L
E
F
G
---
E
G
L
W
I
L
D
Q
K
I
M
S
W
F
S
E
-----
Q
Y
--------
F
S
R
E
------
E
-
D
------
K
F
N
P
L
-
A
S
V
I
F
A
---
D
L
E
N
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
E
G
E
V
F
G
Q
M
L
R
R
A
G
V
E
A
S
I
V
R
Y
R
G
V
L
H
G
F
I
N
Y
Y
-
P
V
---
L
K
A
A
-
R
D
A
I
N
Q
I
A
A
L
L
----
21
PsiBlast_CBE
84.62
36%
-105
- C1 -
1JJI
1
?
D:
[56-308]
----------------------------------------------------------------------------------------------------------------
V
E
D
R
T
I
K
G
R
-
N
G
--
D
I
R
V
R
V
Y
Q
Q
K
P
D
S
---
P
V
L
V
Y
Y
H
G
G
G
F
V
I
C
S
I
E
--
S
H
D
A
L
C
R
R
I
A
R
L
S
N
-
S
T
V
V
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
Y
D
C
Y
D
A
T
K
W
V
A
E
N
A
E
E
L
R
I
D
P
S
K
I
F
V
G
G
D
S
A
G
G
N
L
A
A
A
V
S
I
M
A
R
D
S
G
E
--
D
F
I
K
H
Q
I
L
I
Y
P
V
V
N
F
V
A
P
T
P
------
S
L
L
E
F
G
---
E
G
L
W
I
L
D
Q
K
I
M
S
W
F
S
E
-----
Q
Y
--------
F
S
R
E
------
E
-
D
------
K
F
N
P
L
-
A
S
V
I
F
A
---
D
L
E
N
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
E
G
E
V
F
G
Q
M
L
R
R
A
G
V
E
A
S
I
V
R
Y
R
G
V
L
H
G
F
I
N
Y
Y
-
P
V
---
L
K
A
A
-
R
D
A
I
N
Q
I
A
A
L
L
----
41
HHSearch
84.16
30%
-87
- C1 -
3QH4
-
?
A:
[8-311]
----------------------------------
V
D
R
L
D
P
L
L
R
A
V
A
T
-
A
R
I
D
--------------
F
------
T
--
A
E
S
I
L
T
I
R
E
S
M
N
Q
R
R
--
R
E
A
A
A
T
E
T
---
A
-
A
-
A
G
V
A
V
A
D
D
V
V
T
G
E
-
A
G
R
-
P
V
P
V
R
I
Y
R
A
A
P
--
T
P
A
P
V
V
V
Y
C
H
A
G
G
F
A
L
G
N
L
D
--
T
D
H
R
Q
C
L
E
L
A
R
R
A
R
-
C
A
V
V
S
V
D
Y
R
L
A
----
P
E
H
P
Y
P
A
A
L
H
D
A
I
E
V
L
T
W
V
V
G
N
A
T
R
L
G
F
D
A
R
R
L
A
V
A
G
S
S
A
G
A
T
L
A
A
G
L
A
H
G
A
A
D
G
S
L
--
P
P
V
I
F
Q
L
L
H
Q
P
V
L
D
D
R
P
T
A
-------
S
R
S
E
F
R
A
T
P
--------
A
F
D
G
-
E
-
A
A
S
L
M
W
R
H
--------
Y
L
A
G
------
Q
--------
T
P
S
P
E
-
S
V
P
G
R
R
G
--
Q
L
A
G
L
P
A
T
L
I
T
C
G
E
I
D
P
F
R
D
E
V
L
D
Y
A
Q
R
L
L
G
A
G
V
S
T
E
L
H
I
F
P
R
A
C
H
G
F
D
S
L
L
-
P
E
---
W
T
T
S
-
Q
R
L
F
A
M
Q
G
H
A
L
A
D
A
F
22
PsiBlast_CBE
83.56
36%
-103
- C1 -
1JJI
1
?
C:
[56-308]
----------------------------------------------------------------------------------------------------------------
V
E
D
R
T
I
K
G
R
-
N
G
--
D
I
R
V
R
V
Y
Q
Q
K
P
D
S
---
P
V
L
V
Y
Y
H
G
G
G
F
V
I
C
S
I
E
--
S
H
D
A
L
C
R
R
I
A
R
L
S
N
-
S
T
V
V
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
Y
D
C
Y
D
A
T
K
W
V
A
E
N
A
E
E
L
R
I
D
P
S
K
I
F
V
G
G
D
S
A
G
G
N
L
A
A
A
V
S
I
M
A
R
D
S
G
E
--
D
F
I
K
H
Q
I
L
I
Y
P
V
V
N
F
V
A
P
T
P
------
S
L
L
E
F
G
---
E
G
L
W
I
L
D
Q
K
I
M
S
W
F
S
E
-----
Q
Y
--------
F
S
R
E
------
E
-
D
------
K
F
N
P
L
-
A
S
V
I
F
A
---
D
L
E
N
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
E
G
E
V
F
G
Q
M
L
R
R
A
G
V
E
A
S
I
V
R
Y
R
G
V
L
H
G
F
I
N
Y
Y
-
P
V
---
L
K
A
A
-
R
D
A
I
N
Q
I
A
A
L
L
----
37
Fugue
82.63
27%
-89
- C1 -
4C88
-
?
A:
[17-354]
-------
G
M
P
T
I
N
S
I
Q
T
T
V
N
G
V
V
K
I
V
K
P
F
N
N
D
I
A
G
E
Q
F
D
P
H
V
L
Q
T
L
---------------------
T
A
F
K
Q
P
A
I
L
E
N
D
L
A
A
L
R
S
G
S
L
T
P
A
--
I
------
A
DP-
V
-
G
-
D
A
V
T
V
Q
S
R
N
I
T
A
L
-
N
R
--
T
V
S
V
E
W
L
T
P
Q
N
V
I
N
H
-
T
V
L
V
Y
F
H
G
G
A
F
Y
G
G
V
P
G
--
N
N
T
V
L
L
K
L
V
A
A
K
S
H
-
C
E
I
L
N
V
D
Y
S
L
A
----
P
E
A
P
A
P
A
G
I
L
D
G
L
A
I
F
Q
Y
L
E
Q
R
D
A
E
-----
T
M
I
T
V
A
G
D
S
A
G
A
N
V
I
M
A
A
T
N
L
N
Q
Q
L
G
S
--
N
R
I
N
Q
Q
L
L
L
Y
P
-
V
T
A
P
N
A
D
H
A
G
P
-
L
W
D
L
A
A
F
P
I
I
D
S
Q
R
A
I
L
T
N
Y
H
D
L
F
R
Q
L
D
S
I
M
T
D
Y
--------
Y
V
P
E
------
N
F
D
------
S
H
S
P
L
-
I
S
P
L
H
Q
E
--
N
F
T
M
T
P
P
T
T
I
M
V
G
E
F
D
P
F
R
P
Q
A
W
A
Y
A
Q
R
L
A
A
A
D
T
A
T
T
F
I
Q
Y
Q
G
L
N
H
A
F
A
P
L
V
-
D
Q
---
Y
W
Q
S
-
Q
D
V
A
Q
V
M
A
A
A
L
I
---
32
Fugue
78.29
30%
-90
* C1 *
1JJI
1
?
A:
[1-311]
----------------------------------------
M
L
D
M
P
I
D
-
P
V
Y
Y
Q
L
A
E
Y
F
D
S
L
P
K
F
D
Q
F
S
S
A
R
E
Y
R
E
A
I
N
R
I
Y
E
E
R
N
R
Q
L
S
Q
H
--
E
------
R
---
V
-
E
----
R
V
E
D
R
T
I
K
G
R
-
N
G
--
D
I
R
V
R
V
Y
Q
Q
K
P
---
D
S
P
V
L
V
Y
Y
H
G
G
G
F
V
I
C
S
I
E
--
S
H
D
A
L
C
R
R
I
A
R
L
S
N
-
S
T
V
V
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
Y
D
C
Y
D
A
T
K
W
V
A
E
N
A
E
E
L
R
I
D
P
S
K
I
F
V
G
G
D
S
A
G
G
N
L
A
A
A
V
S
I
M
A
R
D
S
G
E
--
D
F
I
K
H
Q
I
L
I
Y
P
V
V
N
F
V
A
P
T
P
S
L
L
-
E
F
G
E
G
L
W
I
L
D
Q
K
I
M
S
W
F
S
E
Q
Y
---------
F
S
R
E
--------
E
D
K
F
------
N
-
P
------
L
A
S
V
I
-
F
A
D
L
E
N
L
-------
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
E
G
E
V
F
G
Q
M
L
R
R
A
G
V
E
A
S
I
V
R
Y
R
G
V
L
H
G
F
I
N
Y
Y
-
P
V
---
L
K
A
A
-
R
D
A
I
N
Q
I
A
A
L
L
V
F
D
-
3
PsiBlast_PDB
77.71
32%
-99
- C1 -
3ZWQ
-
?
A:
[56-310]
---------------------------------------------------------------------------------------------------------------------
I
P
G
R
-
G
G
--
P
I
R
A
R
V
Y
R
P
R
D
G
E
R
-
L
P
A
V
V
Y
Y
H
G
G
G
F
V
L
G
S
V
E
--
T
H
D
H
V
C
R
R
L
A
N
L
S
G
-
A
V
V
V
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
E
D
A
Y
D
A
A
K
W
V
A
D
N
Y
D
K
L
G
V
D
N
G
K
I
A
V
A
G
D
S
A
G
G
N
L
A
A
V
T
A
I
M
A
R
D
R
G
E
--
S
F
V
K
Y
Q
V
L
I
Y
P
A
V
N
L
T
G
S
P
T
-------
V
S
R
V
E
Y
S
G
P
E
Y
V
I
L
T
A
D
L
M
A
W
F
G
-----
R
Q
Y
--------
F
S
K
P
------
Q
-
D
------
A
L
S
P
Y
-
A
S
P
I
F
A
---
D
L
S
N
L
P
P
A
L
V
I
T
A
E
Y
D
P
L
R
D
E
G
E
L
Y
A
H
L
L
K
T
R
G
V
R
A
V
A
V
R
Y
N
G
V
I
H
G
F
V
N
F
Y
-
P
I
---
L
E
E
G
-
R
E
A
V
S
Q
I
A
A
S
I
K
S
M
-
2
PsiBlast_PDB
77.05
32%
-96
- C1 -
2YH2
1
?
A:
[56-310]
---------------------------------------------------------------------------------------------------------------------
I
P
G
R
-
G
G
--
P
I
R
A
R
V
Y
R
P
R
D
G
E
R
-
L
P
A
V
V
Y
Y
H
G
G
G
F
V
L
G
S
V
E
--
T
H
D
H
V
C
R
R
L
A
N
L
S
G
-
A
V
V
V
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
E
D
A
Y
D
A
A
K
W
V
A
D
N
Y
D
K
L
G
V
D
N
G
K
I
A
V
A
G
D
S
A
G
G
N
L
A
A
V
T
A
I
M
A
R
D
R
G
E
--
S
F
V
K
Y
Q
V
L
I
Y
P
A
V
N
L
T
G
S
P
T
-------
V
S
R
V
E
Y
S
G
P
E
Y
V
I
L
T
A
D
L
M
A
W
F
G
-----
R
Q
Y
--------
F
S
K
P
------
Q
-
D
------
A
L
S
P
Y
-
A
S
P
I
F
A
---
D
L
S
N
L
P
P
A
L
V
I
T
A
E
Y
D
P
L
R
D
E
G
E
L
Y
A
H
L
L
K
T
R
G
V
R
A
V
A
V
R
Y
N
G
V
I
H
G
F
V
N
F
Y
-
P
I
---
L
E
E
G
-
R
E
A
V
S
Q
I
A
A
S
I
K
S
M
-
47
HHSearch
75.36
30%
-88
- C1 -
1LZL
-
?
A:
[47-318]
------------------------------------------------------------------------------------------------------------
D
G
V
S
L
R
E
L
S
A
P
G
L
-
D
G
D
P
E
V
K
I
R
F
V
T
P
D
N
T
A
G
P
V
P
V
L
L
W
I
H
G
G
G
F
A
I
G
T
A
E
--
S
S
D
P
F
C
V
E
V
A
R
E
L
G
-
F
A
V
A
N
V
E
Y
R
L
A
----
P
E
T
T
F
P
G
P
V
N
D
C
Y
A
A
L
L
Y
I
H
A
H
A
E
E
L
G
I
D
P
S
R
I
A
V
G
G
Q
S
A
G
G
G
L
A
A
G
T
V
L
K
A
R
D
E
G
V
--
V
P
V
A
F
Q
F
L
E
I
P
E
L
D
D
R
L
E
------
T
V
S
M
T
N
F
V
D
T
P
--------
L
W
H
R
-
P
-
N
A
I
L
S
W
K
Y
--------
Y
L
G
E
------
S
-
Y
SGPEDP
D
V
S
I
Y
-
A
A
P
S
R
A
T
--
D
L
T
G
L
P
P
T
Y
L
S
T
M
E
L
D
P
L
R
D
E
G
I
E
Y
A
L
R
L
L
Q
A
G
V
S
V
E
L
H
S
F
P
G
T
F
H
G
S
A
L
V
A
-
T
A
A
V
S
E
R
G
A
-
A
E
A
L
T
A
I
R
R
G
L
R
S
--
46
HHSearch
74.76
24%
-90
- C1 -
3GA7
2
AES_SALTY
A:
[13-322]
----------------------------------
L
T
R
L
S
D
E
M
T
A
V
V
N
F
Q
Q
----------------------------
D
I
E
T
Q
R
Q
Y
Y
L
L
E
R
R
F
W
------
N
---
A
-
D
A
P
S
M
T
T
R
T
C
A
V
P
T
P
-
Y
G
--
D
V
T
T
R
L
Y
S
P
Q
P
--
T
S
Q
A
T
L
Y
Y
L
H
G
G
G
F
I
L
G
N
L
D
--
T
H
D
R
I
M
R
L
L
A
R
Y
T
G
-
C
T
V
I
G
I
D
Y
S
L
S
----
P
Q
A
R
Y
P
Q
A
I
E
E
T
V
A
V
C
S
Y
F
S
Q
H
A
D
E
Y
S
L
N
V
E
K
I
G
F
A
G
D
S
A
G
A
M
L
A
L
A
S
A
L
W
L
R
D
K
H
I
RC
G
N
V
I
A
I
L
L
W
Y
G
L
Y
G
L
Q
D
S
V
S
R
R
L
-
F
G
--
G
A
W
D
-----------
G
L
T
R
-
E
-
D
L
D
M
Y
E
K
A
--------
Y
L
R
N
D-----
E
-
D
------
R
E
S
P
W
-
Y
C
L
F
N
N
D
--
L
T
R
D
V
P
P
C
F
I
A
S
A
E
F
D
P
L
I
D
D
S
R
L
L
H
Q
T
L
Q
A
H
Q
Q
P
C
E
Y
K
M
Y
P
G
T
L
H
A
F
L
H
Y
S
-
R
M
---
M
T
I
A
-
D
D
A
L
Q
D
G
A
R
F
F
M
A
R
M
49
HHSearch
74.60
29%
-95
- C1 -
2HM7
1
?
A:
[24-309]
----------------------------------------------------------------------------
H
L
S
A
Q
Q
F
R
S
Q
Q
S
L
F
P
--
P
------
V
---
K
K
E
-
P
V
A
E
V
R
E
F
D
M
D
L
P
-
G
R
--
T
L
K
V
R
M
Y
R
P
E
G
V
E
P
P
Y
P
A
L
V
Y
Y
H
G
G
S
W
V
V
G
D
L
E
--
T
H
D
P
V
C
R
V
L
A
K
-
D
G
R
A
V
V
F
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
E
D
A
Y
D
A
L
Q
W
I
A
E
R
A
A
D
F
H
L
D
P
A
R
I
A
V
G
G
D
S
A
G
G
N
L
A
A
V
T
S
I
L
A
K
E
R
G
G
--
P
A
L
A
F
Q
L
L
I
Y
P
S
T
G
Y
D
P
A
H
P
P
----
A
S
I
E
E
N
A
E
G
------
Y
--
L
L
T
G
-
G
-
M
M
L
W
F
R
D
Q
--------
Y
L
N
S
------
L
E
E
------
L
T
H
P
W
-
F
S
P
V
L
Y
P
--
D
L
S
G
L
P
P
A
Y
I
A
T
A
Q
Y
D
P
L
R
D
V
G
K
L
Y
A
E
A
L
N
K
A
G
V
K
V
E
I
E
N
F
E
D
L
I
H
G
F
A
Q
F
Y
-
S
L
---
S
P
G
A
-
T
K
A
L
V
R
I
A
E
K
L
R
D
A
L
19
PsiBlast_PDB
73.10
29%
-102
- C1 -
3AIM
4
?
A:
[70-320]
---------------------------------------------------------------------------------------------------------------------
I
P
G
S
-
E
T
--
N
I
K
A
R
V
Y
-
Y
P
K
T
Q
G
P
Y
G
V
L
V
Y
Y
H
G
G
G
F
V
L
G
D
I
E
--
S
Y
D
P
L
C
R
A
I
T
N
S
C
Q
-
C
V
T
I
S
V
D
Y
R
L
A
----
P
E
N
K
F
P
A
A
V
V
D
S
F
D
A
L
K
W
V
Y
N
N
S
E
K
F
N
-
G
K
Y
G
I
A
V
G
G
D
S
A
G
G
N
L
A
A
V
T
A
I
L
S
-
K
K
E
N
--
I
K
L
K
Y
Q
V
L
I
Y
P
A
V
S
----------------
F
D
L
I
T
K
S
L
Y
D
N
G
E
G
F
F
L
T
R
E
H
I
D
W
F
G
Q
Q
--------
Y
L
R
S
------
F
-
A
------
D
L
L
D
F
R
F
S
P
I
L
A
---
D
L
N
D
L
P
P
A
L
I
I
T
A
E
H
D
P
L
R
D
Q
G
E
A
Y
A
N
K
L
L
Q
S
G
V
Q
V
T
S
V
E
F
N
N
V
I
H
G
F
V
S
F
F
-
P
F
---
I
E
Q
G
-
R
D
A
I
G
L
I
G
Y
V
L
R
K
V
F
17
PsiBlast_PDB
72.18
29%
-99
- C1 -
3AIL
3
?
A:
[70-320]
---------------------------------------------------------------------------------------------------------------------
I
P
G
S
-
E
T
--
N
I
K
A
R
V
Y
-
Y
P
K
T
Q
G
P
Y
G
V
L
V
Y
Y
H
G
G
G
F
V
L
G
D
I
E
--
S
Y
D
P
L
C
R
A
I
T
N
S
C
Q
-
C
V
T
I
S
V
D
Y
R
L
A
----
P
E
N
K
F
P
A
A
V
V
D
S
F
D
A
L
K
W
V
Y
N
N
S
E
K
F
N
-
G
K
Y
G
I
A
V
G
G
D
S
A
G
G
N
L
A
A
V
T
A
I
L
S
-
K
K
E
N
--
I
K
L
K
Y
Q
V
L
I
Y
P
A
V
S
----------------
F
D
L
I
T
K
S
L
Y
D
N
G
E
G
F
F
L
T
R
E
H
I
D
W
F
G
Q
Q
--------
Y
L
R
S
------
F
-
A
------
D
L
L
D
F
R
F
S
P
I
L
A
---
D
L
N
D
L
P
P
A
L
I
I
T
A
E
H
D
P
L
R
D
Q
G
E
A
Y
A
N
K
L
L
Q
S
G
V
Q
V
T
S
V
R
F
N
N
V
I
H
G
F
V
S
F
F
-
P
F
---
I
E
Q
G
-
R
D
A
I
G
L
I
G
Y
V
L
R
K
V
F
42
HHSearch
71.78
26%
-94
- C1 -
3WJ1
1
?
A:
[21-300]
----------------------------------------------------------------------------
K
A
S
V
D
E
V
R
K
I
F
R
Q
L
A
--
S
------
A
---
A
P
K
A
E
V
R
K
V
E
D
I
K
I
P
G
S
-
E
T
--
S
I
N
A
R
V
Y
F
P
K
A
K
-
G
P
Y
G
V
L
V
Y
L
H
G
G
G
F
V
I
G
D
V
E
--
S
Y
D
P
L
C
R
A
I
T
N
A
C
N
-
C
V
V
V
S
V
D
Y
R
L
A
----
P
E
Y
K
F
P
S
A
V
I
D
S
F
D
A
T
N
W
I
Y
N
N
L
D
K
F
D
G
-
E
M
G
I
A
I
A
G
D
S
A
G
G
N
L
A
A
V
V
A
L
L
S
K
G
--
K
--
L
D
L
K
Y
Q
I
L
I
Y
P
A
V
G
F
D
S
V
S
------
R
S
M
I
E
Y
S
D
-
G
-----
F
--
F
L
T
R
-
E
-
H
I
E
W
F
G
S
Q
--------
Y
L
R
S
------
P
A
D
------
L
L
D
F
R
-
F
S
P
I
I
A
Q
--
D
L
S
G
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
Q
G
E
A
Y
A
N
R
L
L
Q
A
G
V
P
V
T
S
V
R
F
N
N
V
I
H
G
F
L
S
F
F
-
P
L
---
I
D
Q
G
-
K
D
A
I
G
L
I
G
S
V
L
R
R
T
-
5
PsiBlast_PDB
71.74
32%
-96
- C1 -
1EVQ
2
?
A:
[62-307]
---------------------------------------------------------------------------------------------------------------------------------
V
R
M
Y
R
P
E
G
V
E
P
P
Y
P
A
L
V
Y
Y
H
G
G
G
W
V
V
G
D
L
E
--
T
H
D
P
V
C
R
V
L
A
K
D
G
R
-
A
V
V
F
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
E
D
A
Y
D
A
L
Q
W
I
A
E
R
A
A
D
F
H
L
D
P
A
R
I
A
V
G
G
D
S
A
G
G
N
L
A
A
V
T
S
I
L
A
K
E
R
G
G
--
P
A
L
A
F
Q
L
L
I
Y
P
----------------------
S
T
G
Y
D
P
A
H
P
P
A
S
I
E
E
N
A
E
G
Y
L
L
T
G
G
M
M
L
-----
W
F
R
D
Q
Y
LNSL
E
-
E
------
L
T
H
P
W
-
F
S
P
V
L
Y
P
--
D
L
S
G
L
P
P
A
Y
I
A
T
A
Q
Y
D
P
L
R
D
V
G
K
L
Y
A
E
A
L
N
K
A
G
V
K
V
E
I
E
N
F
E
D
L
I
H
G
F
A
Q
F
Y
-
S
L
---
S
P
G
A
-
T
K
A
L
V
R
I
A
E
K
L
R
D
--
20
PsiBlast_PDB
71.59
29%
-99
- C1 -
3AIN
5
?
A:
[70-320]
---------------------------------------------------------------------------------------------------------------------
I
P
G
S
-
E
T
--
N
I
K
A
R
V
Y
-
Y
P
K
T
Q
G
P
Y
G
V
L
V
Y
Y
H
G
G
G
F
V
L
G
D
I
E
--
S
Y
D
P
L
C
R
A
I
T
N
S
C
Q
-
C
V
T
I
S
V
D
Y
R
L
A
----
P
E
N
K
F
P
A
A
V
V
D
S
F
D
A
L
K
W
V
Y
N
N
S
E
K
F
N
-
G
K
Y
G
I
A
V
G
G
D
S
A
G
G
N
L
A
A
V
T
A
I
L
S
-
K
K
E
N
--
I
K
L
K
Y
Q
V
L
I
Y
P
A
V
S
----------------
F
D
L
I
T
K
S
L
Y
D
N
G
E
G
F
F
L
T
R
E
H
I
D
W
F
G
Q
Q
--------
Y
L
R
S
------
F
-
A
------
D
L
L
D
F
R
F
S
P
I
L
A
---
D
L
N
D
L
P
P
A
L
I
I
T
A
E
H
D
P
L
R
D
Q
G
E
A
Y
A
N
K
L
L
Q
S
G
V
Q
V
T
S
V
G
F
N
N
V
I
H
G
F
V
S
F
F
-
P
F
---
I
E
Q
G
-
R
D
A
I
G
L
I
G
Y
V
L
R
K
V
F
43
HHSearch
71.51
25%
-98
- C1 -
3WJ2
-
?
A:
[27-308]
-----------------------------------------------------------------------------
I
E
P
A
M
L
R
N
F
L
D
E
S
S
--
L
------
S
S
RG
A
-
P
V
E
I
K
E
I
K
D
Y
K
I
K
L
D
-
G
R
--
T
L
N
A
R
M
Y
D
D
N
N
---
A
K
S
A
I
L
Y
Y
H
G
G
G
F
L
F
G
N
I
E
--
T
Y
D
N
Y
C
R
F
L
A
K
E
S
G
-
V
K
I
I
S
I
E
Y
R
L
A
----
P
E
H
K
F
P
D
A
F
N
D
A
Y
D
S
F
H
Y
I
A
K
K
K
K
D
F
G
I
E
-
G
R
I
G
V
A
G
D
S
A
G
A
N
L
A
A
A
L
C
L
K
C
R
D
G
K
T
--
E
M
P
A
V
Q
V
L
F
Y
P
S
L
A
P
D
N
F
------
S
R
S
F
I
E
Y
S
D
N
Y
--------
V
L
T
G
-
K
-
M
I
R
Y
F
G
N
M
--------
Y
S
K
N
----------------
I
N
P
Y
-
F
S
P
L
V
A
D
--
D
F
S
N
L
P
P
A
I
M
V
T
N
E
Y
D
P
L
R
D
P
E
E
T
Y
V
K
K
L
R
E
A
G
V
R
A
V
G
I
R
G
I
G
M
I
H
G
S
A
T
D
F
-
E
V
---
S
D
G
A
-
R
N
I
V
K
M
V
A
R
I
I
P
D
Y
L
51
HHSearch
71.32
25%
-93
- C1 -
1JKM
-
?
A:
[87-366]
------------------------------------------------------------------------------------------------------------
D
D
V
E
T
S
T
E
T
I
L
G
V
D
G
N
--
E
I
T
L
H
V
F
R
P
A
G
V
E
G
V
L
P
G
L
V
Y
T
H
G
G
G
M
T
I
L
T
T
D
N
R
V
H
R
R
W
C
T
D
L
A
A
-
A
G
-
S
V
V
V
M
V
D
F
R
N
A
WTAE
G
H
H
P
F
P
S
G
V
E
D
C
L
A
A
V
L
W
V
D
E
H
R
E
S
L
G
L
--
S
G
V
V
V
Q
G
E
S
G
G
G
N
L
A
I
A
T
T
L
L
A
K
R
R
G
R
L-
D
A
I
D
G
V
Y
A
S
I
P
Y
I
S
G
G
Y
A
W
D
H
E
R
R
L
T
E
L
P
S
L
V
E
N
D
---
G
-
Y
--
F
I
E
N
-
G
-
G
M
A
L
L
V
R
A
--------
Y
D
P
T
------
G
E
H
------
A
E
D
P
I
-
A
W
P
Y
F
A
S
ED
E
L
R
G
L
P
P
F
V
V
A
V
N
E
L
D
P
L
R
D
E
G
I
A
F
A
R
R
L
A
R
A
G
V
D
V
A
A
R
V
N
I
G
L
V
H
G
A
D
V
I
F
R
H
W
---
L
P
A
A
L
E
S
T
V
R
D
V
A
G
F
A
A
D
R
-
7
PsiBlast_PDB
69.58
32%
-92
- C1 -
1QZ3
1
?
A:
[62-307]
---------------------------------------------------------------------------------------------------------------------------------
V
R
M
Y
R
P
E
G
V
E
P
P
Y
P
A
L
V
Y
Y
H
G
G
G
W
V
V
G
D
L
E
--
T
H
D
P
V
C
R
V
L
A
K
D
G
R
-
A
V
V
F
S
V
D
Y
R
L
A
----
P
E
H
K
F
P
A
A
V
E
D
A
Y
D
A
L
Q
W
I
A
E
R
A
A
D
F
H
L
D
P
A
R
I
A
V
G
G
D
S
A
G
G
N
L
A
A
V
T
S
I
L
A
K
E
R
G
G
--
P
A
L
A
F
Q
L
L
I
Y
P
----------------------
S
T
G
Y
D
P
A
H
P
P
A
S
I
E
E
N
A
E
G
Y
L
L
T
G
G
M
S
L
W
F
L
D
Q
Y
L
N
S
L-----
E
-
E
------
L
T
H
P
W
-
F
S
P
V
L
Y
P
--
D
L
S
G
L
P
P
A
Y
I
A
T
A
Q
Y
D
P
L
R
D
V
G
K
L
Y
A
E
A
L
N
K
A
G
V
K
V
E
I
E
N
F
E
D
L
I
H
G
F
A
Q
F
Y
-
S
L
---
S
P
G
A
-
T
K
A
L
V
R
I
A
E
K
L
R
D
--