@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0131: (2016-03-12 )
MDISSTEIWDAIRRNSYLLYYQPKVDAKTNKIIGFEGLVRLKTATTILAPIDFFDDIVLLNATREMQDFVAETAIKQINQLGGRFSISINIPAHYVASSTYMTFLHDYVKEHLKYPECLEIEIIERGEITELAIADKNLRKIKDLGVKVSMDDFGKGYSSLAYLRSLPIDIVKTDMSFIALLKTDRKQQIIIRAIVNLCHDLGGKVVTEGVEDMEQVEKLREMKVDYFQGYYFSRPLPMEEIKQKYSIV
Atome Classification :
(24 SA)
----------------------------------------------------------------------------------------------------------------.........10........20........30........40..-...-.-...50...---...-----..60.......---.70..---......--80------.------..----.----....90-........100---........110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------MDI
S
S
T
E
I
W
D
A
I
RRN
S
Y
L
L
Y
YQPKVDAKT
N
K
I
I
GFE
G
L
V
R
-
L
K
-
T
A
T
-
T
-
I
L
A
P
I
D
FF---D
D
I
-----
V
L
LNA
T
R
E
M
Q
D
---
F
V
A
E
T
---
A
I
K
Q
I
N
--QL------G------
G
R
----
F
----
S
I
S
I
NI-P
A
H
Y
VA
S
S
T
Y
----
M
T
F
L
H
D
Y
V
K
E
HLKYP
E
C
L
E
I
E
I
I
ERGE
I
T
E
L
A
IAD
K
N
L
R
K
I
K
DLG
V
K
V
S
M
D
D
FG
K
G
Y
S
S
L
A
Y
L
R
SL
P
I
D
I
V
K
T
D
M
S
F
I
A
L
L
KTDR
K
Q
Q
I
I
I
R
A
I
V
N
L
C
H
D
LG
G
K
V
V
T
E
G
V
E
D
M
E
Q
V
E
K
L
R
E
M
K
V
D
Y
F
Q
G
Y
YFSRPL
P
M
E
E
I
K
Q
K
YSIV------
1
PsiBlast_PDB
99.73
97%
-127
- C4 -
4Q6J
9
?
A:
[5-252]
-----------------------------------------------------------------------------------------------------------------
D
I
S
S
T
E
I
W
D
A
I
R
R
N
S
Y
L
L
Y
Y
Q
P
K
V
D
A
K
T
N
K
I
I
G
F
E
G
L
V
R
-
L
K
-
T
A
T
-
T
-
I
L
A
P
I
D
F
F
---
D
D
I
-----
V
L
L
N
A
T
R
E
M
Q
D
---
F
V
A
E
T
---
A
I
K
Q
I
N
--
Q
L
------
G
------
G
R
----
F
----
S
I
S
I
N
I
-
P
A
H
Y
V
A
S
S
T
Y
----
M
T
F
L
H
D
Y
V
K
E
H
L
K
Y
P
E
C
L
E
I
E
I
I
E
R
---
T
E
L
A
I
A
D
K
N
L
R
K
I
K
D
L
G
V
K
V
S
M
D
D
F
G
K
G
Y
S
S
L
A
Y
L
R
S
L
P
I
D
I
V
K
T
D
M
S
F
I
A
L
L
K
T
D
R
K
Q
Q
I
I
I
R
A
I
V
N
L
C
H
D
L
G
G
K
V
V
T
E
G
V
E
D
M
E
Q
V
E
K
L
R
E
M
K
V
D
Y
F
Q
G
Y
Y
F
S
R
P
L
P
M
E
E
I
K
Q
K
Y
S
I
V
------
47
Fugue
75.95
28%
-90
- C4 -
3SY8
2
?
D:
[3-398]
D
L
N
V
L
V
LQ
R
L
V
A
V
T
A
L
K
K
V
VPGSILEAAD
G
K
E
A
V
A
ILED
I
A
I
C
D
LQMSG
M
D
G
L
A
F
L
R
H
A
S
L
S
GKVH
S
V
I
L
SSEVDPIL
R
Q
A
T
I
S
M
I
E
C
L
GLNFLGDE
R
I
T
A
L
L
T
R
Y
NAREVA
E
L
P
S
V
A
D
V
V
R
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
L
I
G
A
E
V
L
A
R
-
W
N
-
H
P
H
-
L
G
V
L
P
P
S
H
F
L
---
Y
V
M
-----
E
T
Y
N
L
V
D
K
L
F
W
---
Q
L
F
S
Q
---
G
L
A
T
R
R
--
K
L
A
Q
L
---
G
------
Q
P
----
I
----
N
L
A
F
N
V
-
H
P
S
Q
L
G
S
R
A
L
----
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
P
E
Q
H
F
L
D
Y
C
S
G
S
L
E
H
H
H
H
28
HHSearch
74.29
28%
-85
- C4 -
2R6O
4
?
A:
[27-277]
-------------------------------------------------------------------------------------------------------------------
L
D
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
I
V
G
G
E
A
L
V
R
-
W
E
D
P
E
R
-
G
-
L
V
M
P
S
A
F
I
---
P
A
A
-----
E
D
T
G
L
I
V
A
L
S
D
---
W
V
L
E
A
---
C
C
T
Q
L
R
--
A
W
------
Q
Q
Q
GRAA
D
D
----
L
----
T
L
S
V
N
I
-
S
T
R
Q
F
E
G
E
H
L
----
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
Q
A
A
D
A
F
A
S
L
L
D
--------
4
PsiBlast_PDB
74.27
30%
-93
- C4 -
4RNH
3
?
A:
[203-449]
---------------------------------------------------------------------------------------------------------------------
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
-
W
Q
-
H
P
R
R
G
-
L
V
P
P
S
E
F
I
---
P
V
L
-----
E
E
I
G
L
V
A
Q
V
G
D
---
W
L
L
A
E
---
A
C
K
Q
L
R
--
S
W
------
H
------
K
A
KVRV
P
----
K
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
----
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
--------
13
PsiBlast_PDB
73.22
26%
-89
- C4 -
4HJF
3
?
A:
[78-322]
---------------------------------------------------------------------------------------------------------------------
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
L
S
G
F
E
A
L
A
R
W
I
H
-
P
R
R
-
G
-
M
L
P
P
D
E
F
L
---
P
L
I
-----
E
E
M
G
L
M
S
E
L
G
A
---
H
M
M
H
A
---
A
A
Q
Q
L
S
--
T
W
R
A
A
H
PA
M
------
G
N
----
L
----
T
V
S
V
N
L
-
S
T
G
E
I
D
R
P
G
L
----
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
------------
25
HHSearch
73.06
27%
-94
- C4 -
3S83
2
?
A:
[4-254]
--------------------------------------------------------------------------------------------------------------------
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
L
S
G
F
E
A
L
A
R
-
W
I
H
P
R
R
-
G
-
M
L
P
P
D
E
F
L
---
P
L
I
-----
E
E
M
G
L
M
S
E
L
G
A
---
H
M
M
H
A
---
A
A
Q
Q
L
S
--
T
W
------
R
A
A
H
PAM
G
N
----
L
----
T
V
S
V
N
L
-
S
T
G
E
I
D
R
P
G
L
----
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
---
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
V
Y
L
N
E
-------
30
HHSearch
72.54
28%
-84
- C4 -
3SY8
1
?
A:
[145-388]
---------------------------------------------------------------------------------------------------------------------
A
D
V
V
R
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
L
I
G
A
E
V
L
A
R
-
W
N
H
P
H
L
-
G
-
V
L
P
P
S
H
F
L
---
Y
V
M
-----
E
T
Y
N
L
V
D
K
L
F
W
---
Q
L
F
S
Q
---
G
L
A
T
R
R
--
K
L
------
A
Q
L
G---
Q
P
----
I
----
N
L
A
F
N
V
-
H
P
S
Q
L
G
S
R
A
L
----
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
P
E
Q
H
F
L
D
Y
----------
2
PsiBlast_PDB
71.56
31%
-91
- C4 -
4RNI
-
?
A:
[41-282]
--------------------------------------------------------------------------------------------------------------------------
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
-
W
Q
-
H
P
R
R
G
-
L
V
P
P
S
E
F
I
---
P
V
L
-----
E
E
I
G
L
V
A
Q
V
G
D
---
W
L
L
A
E
---
A
C
K
Q
L
R
--
S
W
------
H
------
K
A
KVRV
P
----
K
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
----
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
--------
3
PsiBlast_PDB
70.62
31%
-94
- C4 -
4RNJ
-
?
A:
[41-282]
--------------------------------------------------------------------------------------------------------------------------
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
-
W
Q
-
H
P
R
R
G
-
L
V
P
P
S
E
F
I
---
P
V
L
-----
E
E
I
G
L
V
A
Q
V
G
D
---
W
L
L
A
E
---
A
C
K
Q
L
R
--
S
W
------
H
------
K
A
KVRV
P
----
K
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
----
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
--------
5
PsiBlast_PDB
70.37
29%
-88
- C4 -
4RNF
-
?
A:
[203-449]
---------------------------------------------------------------------------------------------------------------------
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
-
W
Q
-
H
P
R
R
G
-
L
V
P
P
S
E
F
I
---
P
V
L
-----
E
E
I
G
L
V
A
Q
V
G
D
---
W
L
L
A
E
---
A
C
K
Q
L
R
--
S
W
------
H
------
K
A
KVRV
P
----
K
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
----
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
N
N
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
--------
9
PsiBlast_PDB
69.68
30%
-90
- C4 -
3N3T
4
?
A:
[29-266]
---------------------------------------------------------------------------------------------------------------------
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
I
V
G
G
E
A
L
V
R
-
W
E
D
P
E
R
-
G
-
L
V
M
P
S
A
F
I
P
A
A
E
D
T
-----
G
L
I
V
A
---
L
S
D
---
W
V
L
E
A
---
C
C
T
Q
L
R
A
W
Q
Q
------
Q
------
G
R
AADD
L
----
T
L
S
V
N
I
-
S
T
R
Q
F
E
G
E
H
L
----
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
-------------------
8
PsiBlast_PDB
69.57
30%
-89
- C4 -
2R6O
4
?
A:
[29-266]
---------------------------------------------------------------------------------------------------------------------
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
I
V
G
G
E
A
L
V
R
-
W
E
D
P
E
R
-
G
-
L
V
M
P
S
A
F
I
P
A
A
E
D
T
-----
G
L
I
V
A
---
L
S
D
---
W
V
L
E
A
---
C
C
T
Q
L
R
A
W
Q
Q
------
Q
------
G
R
AADD
L
----
T
L
S
V
N
I
-
S
T
R
Q
F
E
G
E
H
L
----
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
-------------------
12
PsiBlast_PDB
69.51
27%
-95
- C4 -
3S83
2
?
A:
[10-249]
--------------------------------------------------------------------------------------------------------------------------
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
L
S
G
F
E
A
L
A
R
W
I
H
-
P
R
R
-
G
-
M
L
P
P
D
E
F
L
---
P
L
I
-----
E
E
M
G
L
M
S
E
L
G
A
---
H
M
M
H
A
---
A
A
Q
Q
L
S
--
T
W
R
A
A
H
PA
M
------
G
N
----
L
----
T
V
S
V
N
L
-
S
T
G
E
I
D
R
P
G
L
----
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
---
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
------------
11
PsiBlast_PDB
69.16
27%
-81
- C4 -
3U2E
3
?
A:
[13-252]
--------------------------------------------------------------------------------------------------------------------------
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
L
S
G
F
E
A
L
A
R
W
I
H
-
P
R
R
-
G
-
M
L
P
P
D
E
F
L
---
P
L
I
-----
E
E
M
G
L
M
S
E
L
G
A
---
H
M
M
H
A
---
A
A
Q
Q
L
S
--
T
W
R
A
A
H
PA
M
------
G
N
----
L
----
T
V
S
V
N
L
-
S
T
G
E
I
D
R
P
G
L
----
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
------------
16
PsiBlast_PDB
67.02
27%
-92
- C4 -
4LYK
4
YAHA_ECOLI
A:
[33-265]
--------------------------------------------------------------------------------------------------------------------------
A
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
L
T
G
C
E
V
L
V
R
-
W
E
-
H
P
Q
-
T
-
G
I
I
P
P
D
Q
F
---
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
---
Q
T
A
D
I
---
L
M
P
V
K
H
--
L
L
------
P
------
D
N
----
F
----
H
I
G
I
N
V
-
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
----
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
-----------------
6
PsiBlast_PDB
66.98
31%
-93
- C4 -
4HU3
-
A:
[43-287]
-------------------------------------------------------------------------------------------------------------------------
E
A
I
S
N
N
Q
L
K
L
V
Y
Q
P
Q
I
F
A
E
T
G
E
L
Y
G
I
E
A
L
A
R
-
W
H
-
D
P
L
-
H
-
G
H
V
P
P
S
R
F
-----
I
-----
P
L
A
E
E
I
G
E
I
E
N
I
G
R
W
V
I
A
E
---
A
C
R
Q
L
A
--
E
W
------
R
------
S
Q
----
N
IHIP
A
L
S
V
N
L
-
S
A
L
H
F
R
S
N
Q
L
----
P
N
Q
V
S
D
A
M
H
A
W
G
I
D
G
H
Q
L
T
V
E
I
T
E
S
M
M
M
E
H
D
T
E
I
F
K
R
I
Q
I
L
R
D
M
G
V
G
L
S
V
D
D
F
G
T
G
F
S
G
L
S
R
L
V
S
L
P
V
T
E
I
K
I
D
K
S
F
V
D
R
C
L
T
E
K
R
I
L
A
L
L
E
A
I
T
S
I
G
Q
S
L
N
L
T
V
V
A
E
G
V
E
T
K
E
Q
F
E
M
L
R
K
I
H
C
R
V
I
Q
G
Y
F
F
S
R
P
L
P
A
E
E
I
P
G
W
M
S
S
V
------
7
PsiBlast_PDB
66.67
31%
-98
- C4 -
4HU4
-
DOSP_ECOLI
A:
[43-287]
-------------------------------------------------------------------------------------------------------------------------
E
A
I
S
N
N
Q
L
K
L
V
Y
Q
P
Q
I
F
A
E
T
G
E
L
Y
G
I
E
A
L
A
R
-
W
H
-
D
P
L
-
H
-
G
H
V
P
P
S
R
F
-----
I
-----
P
L
A
E
E
I
G
E
I
E
N
I
G
R
W
V
I
A
E
---
A
C
R
Q
L
A
--
E
W
------
R
------
S
Q
----
N
IHIP
A
L
S
V
N
L
-
S
A
L
H
F
R
S
N
Q
L
----
P
N
Q
V
S
D
A
M
H
A
W
G
I
D
G
H
Q
L
T
V
E
I
T
E
S
M
M
M
E
H
D
T
E
I
F
K
R
I
Q
I
L
R
D
M
G
V
G
L
S
V
D
D
F
G
-----------
L
P
V
T
E
I
K
I
D
K
S
F
V
D
R
C
L
T
E
K
R
I
L
A
L
L
E
A
I
T
S
I
G
Q
S
L
N
L
T
V
V
A
E
G
V
E
T
K
E
Q
F
E
M
L
R
K
I
H
C
R
V
I
Q
G
Y
F
F
S
R
P
L
P
A
E
E
I
P
G
W
M
S
S
V
------
14
PsiBlast_PDB
66.61
27%
-86
- C4 -
4KIE
5
YAHA_ECOLI
A:
[22-254]
--------------------------------------------------------------------------------------------------------------------------
A
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
L
T
G
C
E
V
L
V
R
-
W
E
-
H
P
Q
-
T
-
G
I
I
P
P
D
Q
F
---
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
---
Q
T
A
D
I
---
L
M
P
V
K
H
--
L
L
------
P
------
D
N
----
F
----
H
I
G
I
N
V
-
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
----
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
-----------------
27
HHSearch
65.40
19%
-83
* C4 *
3HV8
1
?
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------
V
I
A
I
L
Q
Q
A
L
E
T
N
S
F
R
L
L
F
Q
P
V
I
S
L
R
G
D
S
H
E
N
Y
E
V
L
L
R
-
L
L
N
P
Q
G
-
Q
-
E
V
P
P
A
E
F
L
---
H
A
A
-----
K
E
A
G
L
A
E
K
I
D
R
---
W
V
I
L
N
---
S
I
K
L
L
A
--
E
H
--------------
Q
----
T
----
K
L
F
V
H
L
-
S
S
A
S
L
Q
D
P
G
L
----
L
P
W
L
G
V
A
L
K
A
A
R
L
P
P
E
S
L
V
F
Q
I
S
E
A
D
A
T
S
Y
L
K
Q
A
K
Q
L
T
Q
G
L
A
T
L
H
C
Q
A
A
I
S
Q
F
G
C
S
L
N
P
F
N
A
L
K
H
L
T
V
Q
F
I
K
I
D
G
S
F
V
Q
D
L
N
Q
V
-
E
N
Q
E
I
L
K
G
L
I
A
E
L
H
E
Q
Q
K
L
S
I
V
P
F
V
E
S
A
S
V
L
A
T
L
W
Q
A
G
A
T
Y
I
Q
G
Y
Y
L
Q
G
P
S
Q
A
M
D
Y
D
------------
15
PsiBlast_PDB
65.25
27%
-85
- C4 -
4LJ3
5
YAHA_ECOLI
A:
[33-265]
--------------------------------------------------------------------------------------------------------------------------
A
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
L
T
G
C
E
V
L
V
R
-
W
E
-
H
P
Q
-
T
-
G
I
I
P
P
D
Q
F
---
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
---
Q
T
A
D
I
---
L
M
P
V
K
H
--
L
L
------
P
------
D
N
----
F
----
H
I
G
I
N
V
-
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
----
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
-----------------
20
PsiBlast_PDB
59.43
30%
-76
- C4 -
3GG0
3
?
A:
[182-394]
-------------------------------------------------------------------------------------------------------------------------------------
Q
A
I
V
E
P
A
K
K
R
V
S
S
F
E
A
L
I
R
-
S
P
-
T
G
G
-
S
----
P
V
E
M
F
---
A
A
I
---------
A
A
E
D
R
Y
R
---
F
D
L
E
S
K
A
Y
A
F
A
L
A
G
--
Q
L
------
P
L-----
G
K
----
H
----
Q
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
----
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
-------------------
17
PsiBlast_PDB
59.23
30%
-69
- C4 -
3GFX
2
?
A:
[182-394]
-------------------------------------------------------------------------------------------------------------------------------------
Q
A
I
V
E
P
A
K
K
R
V
S
S
F
E
A
L
I
R
-
S
P
-
T
G
G
-
S
----
P
V
E
M
F
---
A
A
I
---------
A
A
E
D
R
Y
R
---
F
D
L
E
S
K
A
Y
A
F
A
L
A
G
--
Q
L
------
P
L-----
G
K
----
H
----
Q
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
----
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
-------------------
19
PsiBlast_PDB
58.74
30%
-73
- C4 -
3GFZ
3
?
A:
[182-394]
-------------------------------------------------------------------------------------------------------------------------------------
Q
A
I
V
E
P
A
K
K
R
V
S
S
F
E
A
L
I
R
-
S
P
-
T
G
G
-
S
----
P
V
E
M
F
---
A
A
I
---------
A
A
E
D
R
Y
R
---
F
D
L
E
S
K
A
Y
A
F
A
L
A
G
--
Q
L
------
P
L-----
G
K
----
H
----
Q
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
----
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
-------------------
18
PsiBlast_PDB
56.43
30%
-84
- C4 -
3GFY
1
?
A:
[182-394]
-------------------------------------------------------------------------------------------------------------------------------------
Q
A
I
V
E
P
A
K
K
R
V
S
S
F
E
A
L
I
R
-
S
P
-
T
G
G
-
S
----
P
V
E
M
F
---
A
A
I
---------
A
A
E
D
R
Y
R
---
F
D
L
E
S
K
A
Y
A
F
A
L
A
G
--
Q
L
------
P
L-----
G
K
----
H
----
Q
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
----
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
----------
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
-----------
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
-------------------