@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0132: (2016-03-12 )
MAFYFEEPSRTFSEFLLVPGYSSAECVPTNVSLKTPIVKFKKGEESAITMNIPLVSAIMQAVSDDNMGIALATEGGVSFIFGSQSIESEAAMVSRVKNHKAGFVISDSNISPDKTLQDILDLKEKTGHSTVAVTEDGTAHGKLLGIVTSRDYRVTRMSPDEKVADFMTPFEKLVTANKSTTLKEANNIIWDNKLNALPLVDDNEHLVHMVFRKDYDSNKENKLELLDSSKRYVVGAGINTRDYEERVPALVEAGADILCIDSSEGYSEWQKRTLDYVRGKYGDTVKVGAGNVVDRDGFRYLAEAGADFVKVGVGGGSICITREQKGIGRGQATALIDVAKARDEYFEETGVYIPICSDGGIVYDYHMTLALAMGADFIMLGRYFSRFDESPTNKVNLNGTYMKEYWGEGANRARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVAISLSKVRSTMCNCGALNIPELQQKAKITLVSSTSIVEGGAHDVVVKDASNNLIK
Atome Classification :
(47 SA)
--.........10........20........30...-.....40........50.......-.60......-..70........80...-.....90....--....100.......110.......120-.......130.......140.......150..-......-160....-...170----.........180.......190.......200.......210...-....220.-......230--........-240-.-..-.....250.......260.......270.......280.-......290.......300.......310.......320.......330.......340.......350-.......360.......370......-.380.-......390.......400.....-.---.---410--...-.---.....---420.--....-----------------.--.430.......440.......450.......-.460.......470----..-----.....-.480.......490........500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
A
F
Y
FEEPSR
T
F
S
E
F
L
LVPGYSSA
E
C
VPTNVSLK-TP
I
V
K
FKKGEE
S
A
I
T
MN
I
P
L
V
S
A
I
-
M
Q
A
VSDDNM-
G
I
A
L
ATEG
G
V
S
F
I
FGSQ-SI
E
S
E
A
A
M
V
S
R
--
V
KNHKA
G
F
V
I
SDSNIS
P
D
K
T
L
Q
D
I
L
D
L
-
K
E
KTGH
S
T
V
A
V
TEDGTAH
G
K
L
L
G
I
V
TSR
D
-
Y
R
-
V
TRMS
P
-
D
E
K
V
A
D
F
-
M
T
P
F
------
E
K
L
VTANKST
T
L
K
EAN
N
I
IWDNKLNALPLVDDN
E
H
L
V
H
M
V
F
RKDY-DSNKE
N
K
L
-
E
LLDSSK
R
---
Y
V
V
GAGIN-
T
-
R
-
D
-
Y
E
-
E
R
V
P
A
L
V
EAGA
D
I
L
C
IDSSE
G
Y
S
E
W
Q
K
R
T
L
D
Y
V
RGKYG
D
-
T
V
K
VGAGNVVD
R
D
G
F
R
Y
L
A
E
AGA
D
F
V
K
V
GVGG
G
S
I
C
I
T
REQKGIGRGQ
A
T
A
L
I
D
V
A
K
A
R
D
E
Y
F
E
ETG
V
Y
-
I
P
I
CSDG
G
I
V
Y
D
Y
H
M
T
L
A
L
A
MGA
D
F
I
-
M
L
G
R
Y
-
F
S
R
FDESPT
N
K
V
NLN
G
T
Y
M
K
E
Y
W
G-E---G---A----NRA-R---N
W
Q
RY---DLGG--DKKL-----------------
S
--
F
E
EG
V
D
S
YVPYAGSLKD
N
V
A
I
S
-
L
S
K
V
R
S
T
M-CNCGAL
N
I
P
E
L
Q
Q-----K
A
-----
K
I
T
L
V
-
S
STSIVEGGA
H
D
V
-
V
V
KDASNNLIK
2
PsiBlast_PDB
92.58
71%
-92
- C3 -
1ME9
2
IMDH_TRIFO
A:
[2-483]
---
A
K
Y
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
C
I
P
S
N
V
N
L
S
-
T
P
L
V
K
F
Q
K
G
Q
Q
S
E
I
N
L
K
I
P
L
V
S
A
I
-
M
Q
S
V
S
G
E
K
M
-
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
-
S
I
E
S
Q
A
A
M
V
H
A
--
V
K
N
F
K
A
------------------------------------------------------------------------------------------------------------------------------------
H
N
-
E
L
V
D
S
Q
K
R
---
Y
L
V
G
A
G
I
N
-
T
-
R
-
D
-
F
R
-
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
-
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
E
T
G
I
Y
-
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
-
M
L
G
R
Y
-
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
-
E
---
G
---
S
----
S
R
A
-
R
---
N
W
------------------------------------
F
E
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
-
L
N
K
V
K
S
T
M
-
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
-----
K
I
T
L
V
-
S
S
V
S
I
--------------------
3
PsiBlast_PDB
92.02
71%
-91
- C3 -
1MEH
3
IMDH_TRIFO
A:
[2-483]
---
A
K
Y
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
C
I
P
S
N
V
N
L
S
-
T
P
L
V
K
F
Q
K
G
Q
Q
S
E
I
N
L
K
I
P
L
V
S
A
I
-
M
Q
S
V
S
G
E
K
M
-
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
-
S
I
E
S
Q
A
A
M
V
H
A
--
V
K
N
F
K
A
G
F
V
V
S
-------------------------------------------------------------------------------------------------------------------------------
H
N
-
E
L
V
D
S
Q
K
R
---
Y
L
V
G
A
G
I
N
-
T
-
R
-
D
-
F
R
-
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
-
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
E
T
G
I
Y
-
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
-
M
L
G
R
Y
-
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
-
E
---
G
---
S
----
S
R
A
-
R
---
N
W
-------------------------------------
E
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
-
L
N
K
V
K
S
T
M
-
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
-----
K
I
T
L
V
-
S
S
V
S
I
--------------------
1
PsiBlast_PDB
91.86
71%
-93
- C3 -
1ME8
3
IMDH_TRIFO
A:
[2-492]
---
A
K
Y
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
C
I
P
S
N
V
N
L
S
-
T
P
L
V
K
F
Q
K
G
Q
Q
S
E
I
N
L
K
I
P
L
V
S
A
I
-
M
Q
S
V
S
G
E
K
M
-
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
-
S
I
E
S
Q
A
A
M
V
H
A
--
V
K
N
F
K
A
------------------------------------------------------------------------------------------------------------------------------------
H
N
-
E
L
V
D
S
Q
K
R
---
Y
L
V
G
A
G
I
N
-
T
-
R
-
D
-
F
R
-
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
-
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
E
T
G
I
Y
-
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
-
M
L
G
R
Y
-
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
-
E
---
G
---
S
----
S
R
A
-
R
---
N
W
--------------------------------------
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
-
L
N
K
V
K
S
T
M
-
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
-----
K
I
T
L
V
-
S
S
V
S
I
V
E
G
G
A
H
D
V
-
I
----------
4
PsiBlast_PDB
91.72
71%
-91
- C3 -
1ME7
4
IMDH_TRIFO
A:
[2-492]
---
A
K
Y
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
C
I
P
S
N
V
N
L
S
-
T
P
L
V
K
F
Q
K
G
Q
Q
S
E
I
N
L
K
I
P
L
V
S
A
I
-
M
Q
S
V
S
G
E
K
M
-
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
-
S
I
E
S
Q
A
A
M
V
H
A
--
V
K
N
F
K
A
G
F
V
V
S
D
----------------------------------------------------------------------------------------------------------------------------
V
C
H
N
-
E
L
V
D
S
Q
K
R
---
Y
L
V
G
A
G
I
N
-
T
-
R
-
D
-
F
R
-
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
-
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
E
T
G
I
Y
-
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
-
M
L
G
R
Y
-
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
-
E
---
G
---
S
----
S
R
A
-
R
---
N
W
--------------------------------------
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
-
L
N
K
V
K
S
T
M
-
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
-----
K
I
T
L
V
-
S
S
V
S
I
V
E
G
G
A
H
D
V
-
I
----------
116
HHSearch
90.95
69%
-93
- C3 -
1ME8
3
IMDH_TRIFO
A:
[2-492]
---
A
K
Y
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
C
I
P
S
N
V
N
L
S
-
T
P
L
V
K
F
Q
K
G
Q
Q
S
E
I
N
L
K
I
P
L
V
S
A
I
-
M
Q
S
V
S
G
E
K
M
-
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
-
S
I
E
S
Q
A
A
M
V
H
A
V
K
N
F
K
A
--------------------------------------------------------------------------------------------------------------------------------------
H
N
-
E
L
V
D
S
Q
K
R
---
Y
L
V
G
A
G
I
N
-
T
-
R
-
D
-
F
R
-
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
-
G
D
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
E
T
G
I
Y
-
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
-
M
L
G
R
Y
-
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
-
E
---
G
---
S
----
S
R
A
-
R
---
N
W
--------------------------------------
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
-
L
N
K
V
K
S
T
M
-
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
-----
K
I
T
L
V
-
S
S
V
S
I
V
E
G
G
A
H
D
V
-
I
----------
5
PsiBlast_PDB
88.66
71%
-99
- C3 -
1AK5
1
IMDH_TRIFO
A:
[2-483]
---
A
K
Y
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
C
I
P
S
N
V
N
L
S
-
T
P
L
V
K
F
Q
K
G
Q
Q
S
E
I
N
L
K
I
P
L
V
S
A
I
-
M
Q
S
V
S
G
E
K
M
-
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
-
S
I
E
S
Q
A
A
M
V
H
A
--
V
K
N
F
K
A
------------------------------------------------------------------------------------------------------------------------------------
H
N
-
E
L
V
D
S
Q
K
R
---
Y
L
V
G
A
G
I
N
-
T
-
R
-
D
-
F
R
-
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
-
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
--------------
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
E
T
G
I
Y
-
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
-
M
L
G
R
Y
-
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
-
E
---
G
---
S
----
S
R
-----------------------------------------------
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
-
L
N
K
V
K
S
T
M
-
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
-----
K
I
T
L
V
-
S
S
V
S
I
--------------------
7
PsiBlast_PDB
84.75
35%
-70
- C3 -
3TSB
2
?
A:
[30-508]
------
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
--
D
V
L
P
R
E
V
S
V
K
-
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
-
M
D
T
V
T
E
A
D
M
-
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
-
S
I
E
Q
Q
A
E
Q
V
D
K
--
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
-
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
-
L
D
E
R
K
L
V
G
I
I
T
N
R
D
-
M
R
-
F
I
Q
-
D
Y
-
S
I
K
I
S
D
V
-
M
T
K
-------
E
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
-
E
K
V
I
E
F
P
N
-
S
A
K
D
K
Q
G
R
---
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
-
M
---
G
---
S
----
V
G
A
-
M
E
K
G
S
K
D
R
Y
---
F
Q
E
G
--
N
K
K
L
--------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
----
118
HHSearch
84.34
34%
-67
- C3 -
1ZFJ
1
IMDH_STRPY
A:
[5-490]
----
T
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
--
L
P
N
E
V
D
L
K
-
T
K
L
A
-------
D
N
L
T
L
N
I
P
I
I
T
A
A
-
M
D
T
V
T
G
S
K
M
-
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
-
S
I
T
E
Q
A
E
E
V
R
K
--
V
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
-
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
L
A
-
N
R
K
L
V
G
I
I
T
N
R
D
-
M
R
-
F
I
S
D
-
Y
-
N
A
P
I
S
E
H
-
M
T
S
E
-------
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
-
E
K
V
I
E
F
P
H
-
A
A
K
D
E
F
G
R
---
L
L
V
A
A
A
V
G
-
V
-
T
S
D
-
T
F
-
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
-
P
-
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
-
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
-
M
L
G
S
M
-
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
-
M
---
G
---
S
----
I
A
A
-
M
---
K
K
--------------
N
K
-----------------
L
--
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
-
L
G
G
I
R
S
G
M
-
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
-----
Q
F
V
E
M
-
S
G
A
G
L
I
E
S
H
P
H
D
V
-
Q
I
T
N
E
A
P
N
Y
S
-
18
PsiBlast_PDB
83.60
35%
-97
- C3 -
4DQW
7
?
A:
[30-486]
------------
T
F
D
D
V
L
L
I
P
G
Y
S
--
E
V
L
P
K
D
V
S
L
K
-
T
R
L
T
R
-------
G
I
E
L
N
I
P
L
V
S
A
A
-
M
D
T
V
T
E
A
R
L
-
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
-
G
I
E
Q
Q
A
A
E
V
R
K
--
V
K
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
-
A
R
E
Y
G
F
S
G
F
P
V
V
E
----
Q
G
E
L
V
G
I
V
T
G
R
D
-
L
R
-
V
K
P
N
A
G
-
D
-
T
V
A
A
I
-
M
T
P
K
------
D
K
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
-
E
K
A
K
T
Y
P
L
-
A
S
K
D
E
Q
G
R
---
L
R
V
G
A
A
V
G
-
T
G
A
-
D
-
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
--
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
----
L
E
G
T
G
V
---
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
-
M
M
G
S
M
-
F
A
G
T
E
E
A
P
G
E
-----------------------------------------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
-
M
G
G
L
R
A
A
M
-
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
-
T
G
-----------------------
20
PsiBlast_PDB
83.41
32%
-66
- C3 -
1ZFJ
1
IMDH_STRPY
A:
[7-488]
------
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
--
H
V
L
P
N
E
V
D
L
K
-
T
K
L
A
-------
D
N
L
T
L
N
I
P
I
I
T
A
A
-
M
D
T
V
T
G
S
K
M
-
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
-
S
I
T
E
Q
A
E
E
V
R
K
--
V
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
-
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
-
L
A
N
R
K
L
V
G
I
I
T
N
R
D
-
M
R
-
F
---------
I
S
D
Y
-
N
A
P
I
SEHMTS
E
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
-
E
K
V
I
E
F
P
H
-
A
A
K
D
E
F
G
R
---
L
L
V
A
A
A
V
G
V
T
-
S
-
D
-
T
F
-
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
-
R
T
L
I
-
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
Y
G
K
T
-------
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
-
M
L
G
S
M
-
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
-
M
---
G
SIA
A
----
M
K
K
----------------------------------------
N
KL
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
-
L
G
G
I
R
S
G
M
-
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
-----
Q
F
V
E
M
-
S
G
A
G
L
I
E
S
H
P
H
D
V
-
Q
I
T
N
E
A
P
N
---
117
HHSearch
83.02
36%
-81
- C3 -
3USB
4
?
A:
[29-493]
-----
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
--
L
P
R
E
V
S
V
K
-
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
-
M
D
T
V
T
E
A
D
M
-
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
-
S
I
E
Q
Q
A
E
Q
V
D
K
--
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
-
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
L
D
-
E
R
K
L
V
G
I
I
T
N
R
D
-
M
R
-
F
I
Q
D
Y
--
S
I
K
I
S
D
V
-
M
T
K
E
-------
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
-
E
K
V
I
E
F
P
N
-
S
A
K
D
K
Q
G
R
---
L
L
V
G
A
A
V
G
-
V
-
T
A
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-----------------------------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
-------------------
10
PsiBlast_PDB
82.57
34%
-87
- C3 -
4FXS
3
?
A:
[12-485]
------------
T
F
D
D
V
L
L
V
P
A
H
S
T
--
V
L
P
N
T
A
D
L
R
-
T
R
L
T
K
-------
N
I
A
L
N
I
P
M
V
S
A
S
-
M
D
T
V
T
E
A
R
L
-
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
-
S
I
E
Q
Q
A
A
Q
V
H
Q
--
V
K
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
-
T
H
Y
H
G
F
A
G
F
P
V
V
---
T
E
N
N
E
L
V
G
I
I
T
G
R
D
-
V
R
F
V
T
D
L
T
---
K
S
V
A
A
V
-
M
T
P
K
------
E
R
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
------
E
S
K
P
N
-
A
C
K
D
E
Q
G
R
---
L
R
V
G
A
A
V
G
-
A
-
A
-
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
GS
L
G
---
A
----
M
S
K
-
G
---
S
S
D
R
Y
FQT---
A
--
D
K
L
V
-----------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
8
PsiBlast_PDB
82.46
35%
-79
- C3 -
3TSD
1
?
A:
[30-497]
------
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
--
D
V
L
P
R
E
V
S
V
K
-
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
-
M
D
T
V
T
E
A
D
M
-
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
-
S
I
E
Q
Q
A
E
Q
V
D
K
--
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
-
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
-
L
D
E
R
K
L
V
G
I
I
T
N
R
D
-
M
R
-
F
I
Q
-
D
Y
-
S
I
K
I
S
D
V
-
M
-
K
-------
E
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
-
E
K
V
I
E
F
P
N
-
S
A
K
D
K
Q
G
R
---
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
R
G
-----------------------------------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
E
S
H
P
---------------
15
PsiBlast_PDB
82.04
34%
-80
- C3 -
3USB
4
?
A:
[30-493]
------
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
--
D
V
L
P
R
E
V
S
V
K
-
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
-
M
D
T
V
T
E
A
D
M
-
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
-
S
I
E
Q
Q
A
E
Q
V
D
K
--
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
-
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
-
L
D
E
R
K
L
V
G
I
I
T
N
R
D
-
M
R
-
F
I
Q
-
D
Y
-
S
I
K
I
S
D
V
-
M
T
K
-------
E
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
-
E
K
V
I
E
F
P
N
-
S
A
K
D
K
Q
G
R
---
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-----------------------------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
-------------------
26
PsiBlast_CBE
81.06
35%
-98
- C3 -
4DQW
5
?
B:
[30-486]
------------
T
F
D
D
V
L
L
I
P
G
Y
S
--
E
V
L
P
K
D
V
S
L
K
-
T
R
L
T
R
-------
G
I
E
L
N
I
P
L
V
S
A
A
-
M
D
T
V
T
E
A
R
L
-
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
-
G
I
E
Q
Q
A
A
E
V
R
K
--
V
K
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
-
A
R
E
Y
G
F
S
G
F
P
V
V
E
----
Q
G
E
L
V
G
I
V
T
G
R
D
-
L
R
-
V
------
D
-
T
V
A
A
I
-
M
T
P
K
------
D
K
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
-
E
K
A
K
T
Y
P
L
-
A
S
K
D
E
Q
G
R
---
L
R
V
G
A
A
V
G
-
T
G
A
-
D
-
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
--
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
----
L
E
G
T
G
V
---
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
-
M
M
G
S
M
-
F
A
G
T
E
E
A
P
-----------------------------------------------------------------------------------------
A
L
S
A
I
V
H
Q
L
-
M
G
G
L
R
A
A
M
-
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
-
T
G
-----------------------
106
Fugue
80.91
32%
-67
- C3 -
1ZFJ
1
IMDH_STRPY
A:
[1-490]
SN
W
D
T
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
-
T
K
L
A
D
-------
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
--
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
-
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
--
V
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
-
R
I
S
G
V
P
I
V
-
E
T
L
A
N
R
K
L
V
G
I
I
T
N
R
D
M
R
F
-
I
S
--
D
Y
-
N
A
P
I
S
E
H
M
T
S
E
--------
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
-
E
K
V
I
E
F
P
H
-
A
A
K
D
E
F
G
R
---
L
L
V
A
A
A
V
G
-
V
-
T
S
D
-
T
F
-
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
--
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
Y
------
G
-
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
--M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
---
S
---
I
----
A
------------------
A
M-
K
K
N
K
-----------------
L
--
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
-
Q
M
L
G
G
I
R
S
-
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
-----
Q
F
V
-
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
-
Q
I
T
N
E
A
P
N
Y
S
-
22
PsiBlast_CBE
79.72
32%
-82
- C3 -
1NF7
2
IMDH2_HUMAN
B:
[31-506]
------------
T
Y
N
D
F
L
I
L
P
G
Y
--
I
D
F
T
A
D
Q
V
D
L
T
-
S
A
L
T
K
-------
K
I
T
L
K
T
P
L
V
S
S
P
-
M
D
T
V
T
E
A
G
M
-
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
-
T
P
E
F
Q
A
N
E
V
R
K
--
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
--------------------------------
G
I
I
S
S
R
D
-
I
D
-
F
L
---
E
H
D
C
F
L
E
E
I
-
M
T
K
R
------
E
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
-
K
K
N
R
D
Y
P
L
-
A
S
K
D
A
K
K
Q
---
L
L
C
G
A
A
I
G
-
T
-
H
E
D
-
D
K
-
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
-
L
Q
V
I
G
-
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
----
E
Y
A
R
R
F
G
V
---
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
-
M
M
G
S
L
-
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
-
M
---
G
---
S
----
L
D
A
-
M
--------------------
I
-----------------
K
--
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
-
I
A
G
I
Q
H
S
C
-
Q
D
I
G
A
K
S
L
T
Q
V
R
A
MMYSG
E
L
-----
K
F
E
K
R
-
T
S
S
A
Q
V
E
G
G
V
H
S
L
------------
12
PsiBlast_PDB
79.31
32%
-82
- C3 -
1NF7
3
IMDH2_HUMAN
A:
[31-506]
------------
T
Y
N
D
F
L
I
L
P
G
Y
--
I
D
F
T
A
D
Q
V
D
L
T
-
S
A
L
T
K
-------
K
I
T
L
K
T
P
L
V
S
S
P
-
M
D
T
V
T
E
A
G
M
-
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
-
T
P
E
F
Q
A
N
E
V
R
K
--
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
--------------------------------
G
I
I
S
S
R
D
-
I
D
-
F
L
---
E
H
D
C
F
L
E
E
I
-
M
T
K
R
------
E
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
-
K
K
N
R
D
Y
P
L
-
A
S
K
D
A
K
K
Q
---
L
L
C
G
A
A
I
G
-
T
-
H
E
D
-
D
K
-
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
-
L
Q
V
I
G
-
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
----
E
Y
A
R
R
F
G
V
---
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
-
M
M
G
S
L
-
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
-
M
---
G
---
S
----
L
D
A
-
M
--------------------
I
-----------------
K
--
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
-
I
A
G
I
Q
H
S
C
-
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
-
T
S
S
A
Q
V
E
G
G
V
H
S
L
------------
14
PsiBlast_PDB
78.25
32%
-73
- C3 -
1JR1
3
IMDH2_CRIGR
A:
[31-506]
------------
T
Y
N
D
F
L
I
L
P
G
Y
--
I
D
F
T
A
D
Q
V
D
L
T
-
S
A
L
T
K
-------
K
I
T
L
K
T
P
L
V
S
S
P
-
M
D
T
V
T
E
A
G
M
-
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
-
T
P
E
F
Q
A
N
E
V
R
K
--
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
----
D
R
V
R
--
F
E
A
-
K
---------------
M
G
S
R
L
V
------------------------
I
-
M
T
K
R
------
E
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
---
L
P
I
V
N
E
N
D
E
L
V
A
I
I
A
R
T
D
L
-
K
K
N
R
D
Y
P
L
-
A
S
K
D
A
K
K
Q
---
L
L
C
G
A
A
I
G
-
T
-
H
E
D
-
D
K
-
Y
R
L
D
L
L
A
L
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
M
K
E
K
Y
P
N
-
L
Q
V
I
G
-
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
C
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
----
E
Y
A
R
R
F
G
V
---
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
-
M
M
G
S
L
-
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
-
M
---
G
---
S
----
L
D
A
-
M
--------------------
I
-----------------
K
--
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
-
I
A
G
I
Q
H
S
C
-
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
-
T
S
S
A
Q
V
E
G
G
V
H
S
L
------------
25
PsiBlast_CBE
77.17
33%
-91
- C3 -
4AF0
2
?
A:
[61-537]
------------
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
A
--
S
D
V
S
L
Q
-
S
K
A
T
K
-------
N
I
V
L
N
T
P
F
L
S
S
P
-
M
D
T
V
T
E
D
R
M
-
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
-
S
A
E
E
Q
A
A
M
V
R
R
--
V
K
K
Y
E
N
-----------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
K
Q
---
L
Y
C
G
A
A
I
G
-
T
-
R
-
P
-
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
-
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
----
E
F
A
S
R
F
G
---
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
-
M
M
G
G
L
-
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
-
M
---
G
---
S
----
I
E
A
M
E
---
H
T
----------------GLDNAATARYFSEADAV
K
--
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
-
F
T
G
L
Q
H
S
L
-
Q
D
A
A
I
K
S
V
S
E
L
H
S
-----
C
A
R
S
GS
L
R
F
E
L
R
-
T
A
S
----------------------
21
PsiBlast_CBE
76.75
32%
-90
- C3 -
1NFB
2
IMDH2_HUMAN
B:
[31-498]
------------
T
Y
N
D
F
L
I
L
P
G
Y
--
I
D
F
T
A
D
Q
V
D
L
T
-
S
A
L
T
K
-------
K
I
T
L
K
T
P
L
V
S
S
P
-
M
D
T
V
T
E
A
G
M
-
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
-
T
P
E
F
Q
A
N
E
V
R
K
--
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
------------------
G
I
P
I
T
D
T
G
R
M
G
S
--------------------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
-------
N
R
D
Y
P
L
-
A
S
K
D
A
K
K
Q
---
L
L
C
G
A
A
I
G
-
T
-
H
E
D
-
D
K
-
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
-
L
Q
V
I
G
-
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
----
E
Y
A
R
R
F
G
V
---
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
-
M
M
G
S
L
-
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
-
M
--------------------------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
-
I
A
G
I
Q
H
S
C
-
Q
D
I
G
A
K
S
L
T
Q
V
R
A
MMYSG
E
L
-----
K
F
E
K
R
-
T
S
S
A
Q
--------------------
9
PsiBlast_PDB
76.32
33%
-91
- C3 -
4AF0
2
?
B:
[61-537]
------------
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
A
--
S
D
V
S
L
Q
-
S
K
A
T
K
-------
N
I
V
L
N
T
P
F
L
S
S
P
-
M
D
T
V
T
E
D
R
M
-
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
-
S
A
E
E
Q
A
A
M
V
R
R
--
V
K
K
Y
E
N
-----------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
K
Q
---
L
Y
C
G
A
A
I
G
-
T
-
R
-
P
-
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
-
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
----
E
F
A
S
R
F
G
---
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
-
M
M
G
G
L
-
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
-
M
---
G
---
S
----
I
E
A
M
E
---
H
T
----------------GLDNAATARYFSEADAV
K
--
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
-
F
T
G
L
Q
H
S
L
-
Q
D
A
G
I
K
S
V
S
E
L
H
S
-----
C
A
RSGSL
R
F
E
L
R
-
T
A
S
----------------------
13
PsiBlast_PDB
75.14
32%
-89
- C3 -
1NFB
2
IMDH2_HUMAN
A:
[31-498]
------------
T
Y
N
D
F
L
I
L
P
G
Y
--
I
D
F
T
A
D
Q
V
D
L
T
-
S
A
L
T
K
-------
K
I
T
L
K
T
P
L
V
S
S
P
-
M
D
T
V
T
E
A
G
M
-
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
-
T
P
E
F
Q
A
N
E
V
R
K
--
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
------------------
G
I
P
I
T
D
T
G
R
M
G
S
--------------------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
-------
N
R
D
Y
P
L
-
A
S
K
D
A
K
K
Q
---
L
L
C
G
A
A
I
G
-
T
-
H
E
D
-
D
K
-
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
-
L
Q
V
I
G
-
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
----
E
Y
A
R
R
F
G
V
---
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
-
M
M
G
S
L
-
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
-
M
--------------------------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
-
I
A
G
I
Q
H
S
C
-
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
-
T
S
S
A
Q
--------------------
24
PsiBlast_CBE
72.76
32%
-86
- C3 -
1JR1
3
IMDH2_CRIGR
B:
[31-506]
------------
T
Y
N
D
F
L
I
L
P
G
Y
--
I
D
F
T
A
D
Q
V
D
L
T
-
S
A
L
T
K
-------
K
I
T
L
K
T
P
L
V
S
S
P
-
M
D
T
V
T
E
A
G
M
-
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
-
T
P
E
F
Q
A
N
E
V
R
K
--
V
K
K
Y
E
Q
-----------------------------------------------------------------------------------------------------------------------------------
Y
P
L
-
A
S
K
D
A
K
K
Q
---
L
L
C
G
A
A
I
G
-
T
-
H
E
D
-
D
K
-
Y
R
L
D
L
L
A
L
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
M
K
E
K
Y
P
N
-
L
Q
V
I
G
-
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
C
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
----
E
Y
A
R
R
F
G
V
---
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
-
M
M
G
S
L
-
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
-
M
---
G
---
S
----
L
D
A
-
M
--------------------
I
-----------------
K
--
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
-
I
A
G
I
Q
H
S
C
-
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
-
T
S
S
A
Q
V
E
G
G
V
H
S
L
------------
19
PsiBlast_PDB
72.14
35%
-97
- C3 -
5AHN
2
?
A:
[10-467]
------------
T
F
D
D
V
L
L
I
P
G
Y
S
--
E
V
L
P
K
D
V
S
L
K
-
T
R
L
T
R
-------
G
I
E
L
N
I
P
L
V
S
A
A
-
M
D
T
V
T
E
A
R
L
-
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
-
G
I
E
Q
Q
A
A
E
V
R
K
--
V
K
K
H
------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
-
A
S
K
D
E
Q
G
R
---
L
R
V
G
A
A
V
G
-
T
G
A
-
D
-
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
--
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
----
L
E
G
T
G
V
---
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
-
M
M
G
S
M
-
F
A
G
T
E
E
A
P
G
---------------------------------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
-
M
G
G
L
R
A
A
M
-
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
-
T
G
A
----------------------
121
HHSearch
70.75
31%
-76
- C3 -
2CU0
1
IMDH_PYRHO
A:
[10-480]
------
K
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
--
E
P
K
D
V
D
V
S
-
T
R
I
T
-------
P
N
V
K
L
N
I
P
I
L
S
A
A
-
M
D
T
V
T
E
W
E
M
-
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
-
G
I
E
E
Q
V
E
Q
V
K
R
--
V
K
R
A
E
-----------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
-
A
V
R
D
E
N
G
E
---
L
L
V
A
A
A
V
S
-
P
---
F
-
D
I
-
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
---
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
-
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
-
M
L
G
N
L
-
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
-
M
---
G
---
S
----
L
G
A
-
M
---
M
K
----------YM
K
T
R
K
-----------------
F
--
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
-
V
G
G
L
K
A
G
M
-
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
-----
E
F
V
I
I
-
T
H
A
G
I
K
E
S
H
P
H
D
I
-
I
I
T
N
E
A
P
N
---
27
PsiBlast_CBE
70.44
31%
-68
- C3 -
2CU0
1
IMDH_PYRHO
A:
[16-480]
------------
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
P
K
D
V
D
V
S
T
R
I
T
P
N
V
K
----------
L
N
I
P
I
L
S
A
A
-
M
D
T
V
T
E
W
E
M
-
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
-
G
I
E
E
Q
V
E
Q
V
K
R
--
V
K
R
A
E
-----------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
-
A
V
R
D
E
N
G
E
---
L
L
V
A
A
A
V
S
-
P
-
F
-
D
-
I
--
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
D
A
-
D
F
I
V
--
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
Y
----
G
L
Y
---
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
-
M
L
G
N
L
-
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
-
M
---
G
---
S
----
L
G
A
-
M
M
K---------------
Y
M
K
T
-----------------
R
KF
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
-
V
G
G
L
K
A
G
M
-
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
-----
E
F
V
I
I
-
T
H
A
G
I
K
E
S
H
P
H
D
I
-
I
I
T
N
E
A
P
N
---
57
PsiBlast_CBE
62.81
36%
-69
- C3 -
4MY8
9
?
A:
[103-367]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
A
-
E
Q
V
D
K
V
K
R
SGG
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
-
M
---
G
---
S
----
V
G
A
-
M
E
K
G
S
K
---------------
L
--------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
E
------------------
56
PsiBlast_CBE
62.36
36%
-70
- C3 -
4MY8
7
?
B:
[103-366]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
A
-
E
Q
V
D
K
V
K
R
SGG
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
-
M
---
G
---
S
----
V
G
A
-
M
EK------------------
L
--------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
-------------------
44
PsiBlast_CBE
61.91
36%
-64
- C3 -
4MYA
3
?
B:
[103-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
A
-
E
Q
V
D
K
V
K
R
SGG
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
-
M
---
G
---
S
----
V
G
A
-
M
E
K-----------------
K
L
--------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
----
55
PsiBlast_CBE
61.79
36%
-70
- C3 -
4MY8
4
?
C:
[103-366]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
A
-
E
Q
V
D
K
V
K
R
SGG
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
-
M
---
G
---
S
----
V
G
A
-
M
EK-----------------
K
L
--------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
-------------------
34
PsiBlast_CBE
60.83
36%
-66
- C3 -
4QM1
3
?
B:
[103-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
A
-
E
Q
V
D
K
V
K
R
S
GG
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
-
M
---
G
---
S
----
V
G
A
-
M
E
K-----------------
K
L
--------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
-----
H
V
Q
I
T
K
E
A
P
N
----
77
PsiBlast_CBE
60.80
34%
-56
- C3 -
4R7J
6
?
A:
[102-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
E
Y
P
D
A
N
K
D
N
--------
F
G
R
---
L
R
V
G
A
A
I
G
-
V
-
G
-
Q
-
M
D
--
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
-
P
-
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
-------
D
E
C
V
E
E
A
N
K
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
-
M
I
G
S
L
-
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
-
M
---
G
---
S
LGAM
Q
K
-----------------------------------------
L
--
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
-
L
G
G
L
R
S
S
M
-
G
Y
V
G
A
K
D
I
E
D
F
Q
K
-----
R
A
-----
E
F
V
E
I
-
T
T
A
G
L
K
E
S
H
V
H
D
V
-
T
I
T
H
E
A
P
N
---
45
PsiBlast_CBE
60.62
36%
-62
- C3 -
4MYA
4
?
A:
[103-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
A
-
E
Q
V
D
K
V
K
R
SGG
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
-
M
---
G
---
S
----
V
G
A
-
M
E
K----------------
K
K
L
--------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
----
78
PsiBlast_CBE
60.38
34%
-58
- C3 -
4MZ1
6
?
C:
[102-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
E
Y
P
D
A
N
K
D
N
--------
F
G
R
---
L
R
V
G
A
A
I
G
-
V
-
G
-
Q
-
M
D
--
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
-
P
-
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
-------
D
E
C
V
E
E
A
N
K
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
-
M
I
G
S
L
-
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
-
M
---
G
---
S
LGAM
Q
K
-----------------------------------------
L
--
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
-
L
G
G
L
R
S
S
M
-
G
Y
V
G
A
K
D
I
E
D
F
Q
K
-----
R
A
-----
E
F
V
E
I
-
T
T
A
G
L
K
E
S
H
V
H
D
V
-
T
I
T
H
E
A
P
N
---
35
PsiBlast_CBE
58.58
36%
-63
- C3 -
4QM1
3
?
A:
[103-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
A
-
E
Q
V
D
K
V
K
R
SGG
L
L
V
G
A
A
V
G
V
T
-
A
-
D
-
A
M
-
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
-------
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
-
M
L
G
S
M
-
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
-
M
---
G
---
S
----
V
G
A
-
M
E
K---------------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
-
V
G
G
L
R
A
G
M
-
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
-
S
G
A
G
L
L
------
V
Q
I
T
---------
69
PsiBlast_CBE
55.79
37%
-52
- C3 -
4QNE
3
?
B:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
---
G
---
S
----
L
G
A
-
M
S------------------
L
V
-----------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
66
PsiBlast_CBE
55.69
37%
-50
- C3 -
4X3Z
3
?
B:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
---
G
---
S
----
L
G
A
-
M
S-----------------
K
L
V
-----------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
76
PsiBlast_CBE
55.47
37%
-52
- C3 -
4FO4
3
?
A:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
---
G
---
S
----
L
G
A
-
M
S-----------------
K
L
V
-----------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
67
PsiBlast_CBE
55.38
37%
-48
- C3 -
4X3Z
4
?
A:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
---
G
---
S
----
L
G
A
-
M
S------------------
L
V
-----------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
70
PsiBlast_CBE
55.07
37%
-53
- C3 -
4QNE
3
?
A:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
---
G
---
S
----
L
G
A
-
M
S------------------
L
V
-----------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
75
PsiBlast_CBE
55.02
37%
-48
- C3 -
4FO4
3
?
B:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
---
G
---
S
----
L
G
A
-
M
S-----------------
K
L
V
-----------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
74
PsiBlast_CBE
54.66
37%
-56
- C3 -
4IX2
2
?
A:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
-------------------------------------------------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
73
PsiBlast_CBE
54.62
37%
-56
- C3 -
4IX2
2
?
B:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
-------------------------------------------------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
71
PsiBlast_CBE
54.24
37%
-58
- C3 -
4IX2
3
?
D:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
-------------------------------------------------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
72
PsiBlast_CBE
53.42
37%
-57
- C3 -
4IX2
3
?
C:
[110-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
-
M
-------------------------------------------------------
P
----
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
----
68
PsiBlast_CBE
52.42
37%
-69
- C3 -
4QQ3
3
?
A:
[110-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
-
L
E
I
I
G
-
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
G
-------
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
-
M
V
G
S
M
-
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
-
M
---
G
-------------------------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
-
M
G
G
L
R
S
C
M
-
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
-
S
G
A
----------------------