@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0157: (2016-03-12 )
MRKVRISVRRLVEFVRRSGSIDNRMTSSDRALEGTKIHQLLQKEAGEEYAAEVRLNLDRIVDGIAFSLDGRADGIINGRMIDEIKTTETPMDEITENFRPLHWAQLICYGFMLAEKSDLAEVTLQLTYYQVVDKEVKQFQRVMSREELSVFVDDLLSQYAIWAKASAAWEMKRNKTIQELTFPYDSYRSGQRELAIAVYRTISSEESLFCEAPTGIGKTMSTLFPGIKAMGEGKTDKLFYFTAKTITRQVAEDALDEMRRKGLAARSVTITAKDKICFLDERKCEPDHCQFARGYYDRLNEALFDMLQSEEAITRQVVESYARKYTLCPFELSLDVALFCDVIVCDYNYLFDPVVYLKRFFAEGPGKYTFLVDEVHNLVDRARSMYSATLKKSAVMQVKRGLDAKNNKRLLNAINVMNKDMIALNKKLKDLDGTIYVQKNELIDWNESVLKFTFVAKEWLPQNTQSEIQADVLELYFESLRYVAIADFYDDRYVTQVTKSHGDLEIKQVCLDPSFLLSERLKLGSSSVLFSATLRPIDYYTNLLGGQEDTSRMIFSSPFKQKNMHLLVADYISTKYQMRENSMEAVVDALYALVSGENGNYLFFFPSFLYLQKVYDLFKEKYPNIRLQKQETAMDEERREHFLERFQAENVETLIGFCVLGGVFSEGVDLRGNRLVGAAVVGVGLAQLNHESDLIKDYYNETIGRGFDYAYQIPGMNKVLQAVGRVIRGESDRGVVLLIEERFSADRYRALFPTHWNHAKTVKSTDDISREVAGFWRNS
Atome Classification :
(20 SA)
----------------------------------------.....--....10........20...-.....30........40........50........60........70.....--.-..80.......--.90.....--...100-----...--....110......-.120........---------130.......-----140---.--------------.......-------------.150....--...160.......170..-..---...180-.........-----------------190.....-..200---.....--....-----210..-.....220.------------......230----------...-......240.-.----.....250.......260.........---270.......------280---------..--.-...----------.290..--.....300-----------------.......310----..------------...-----------....320--.......330--------------------------.......-340.......350----.---------......360..--.----..--..370----------------.........380---........390.......400..------.....410....-...420.....-.----------.430-----........-440----.....-----------..450-..--------------......460...-....470.......480.-----------------..-......490---.......500---.......510-..--------......520.......530....-.---------..540.-......550.......560------.---.......570.....-..-580.-..-......590.-----......600..--------...---------------.-----------.610.......620-------------------------------------------------------------------------..-..--....630.......640....------...650----.......660----.........670...----.....680.......-690--------------------------------.--------------------------------------.....---...--700-.----------..-....710...-....720....--..---.730--..---....----.740.......750....----....760.......770--------..---......------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------M
R
K
V
R
--
I
S
V
R
R
L
V
E
F
V
R
RSGSIDNR-MTSSDRAL
E
G
T
K
I
H
Q
L
L
Q
K
EAG
E
E
Y
A
A
E
V
RL
N
L
D
R
I
VDG
I
A
F
SLDGRADGII--N-
G
R
M
I
D
EIKTTE--T
P
M
D
E
I
T
E
--NFR
P
L
H
-----
W
A
Q
--
L
I
C
Y
G
F
M
LAEKS
D
-
L
A
E
-
V
T
L
Q
L
T
Y
Y
---------
Q
V
V
D
K
E
V
K
Q
F
-----
Q
-----
R
--------------
V
M
S
R
E
E
L
-------------
S
V
F
V
D
D
L
L
--
S
Q
Y
A
I
W
AKA
S
A
A
W
EMKRN-K
T
---
I
Q
E
L---TFP
Y
D
S
YRS-----------------G
Q
R
E
L
A
I
A
-
V
Y
R
-----TISSE--E
S
L
F
-----CEAPT-G
I
G
K
T
M
S
T
L
------------
F
P
G
I
K
AM------------GEG-KT
D
K
L
F
Y
F
T
A
-
K
----
T
I
T
R
Q
V
A
E
D
A
L
D
E
M
R
R
--KGLAA
R
S
V
T
---
I
T
AK
D
K
I
C
F
L------DER---------KC--E-P
D
H
----------
C
Q
F
A
R
G
--
Y
Y
D
R
L
N
E
A
-----------------
L
F
D
M
L
Q
S
E
------
E
A
------------
I
T
R
-----------
Q
V
V
E
S
Y
A
--
R
KYTLC
P
F
E
L--------------------------SL
D
V
A
L
F
-
C
D
V
I
V
CD
Y
N
Y
LF
D
----
P
---------
V
V
Y
L
K
R
F
F
AEG--P----G
K
--
Y
T
F
------------------
L
V
D
E
V
H
N
L
V
D
R
----
A
R
S
M
Y
S
A
T
L
K
K
S
A
V
M
Q
V
K
RGLDA------KN
N
K
R
L
L
N
A
I
N
V
-M
N
K
D
M
I
A
L
N
K
K
-
L
----------KDL------D
G
T
I
Y
V
QK-NEL----IDWNE-----------S
V
L
K
--
F
T
--------------
F
V
A
K
E
WLPQN
T
Q
-
S
E
I
Q
A
D
V
L
E
L
Y
F
E
S
L
--
R
-----------------
Y
V
-
A
I
A
DFYDD
R
---
Y
V
T
Q
V
T
KSHG---D
L
E
I
K
Q
V
CL--
D
P
--------
S
F
L
L
S
E
R
L
KLGSS
S
V
L
F
S
A
TLR
P
-
I
---------
D
Y
Y
T
N
L
-LGGQ
E
D
T
S
R
M
IFSSPFKQ-------K---
N
M
H
L
L
V
A
D
YI
S
T
K
Y
Q
-
M
R
-
E
--
N
-
S
M
-
E
A
V
V
D
A
L
Y
A
L
-----VSGENG
N
Y
L
F
F
--------
F
P
S
---------------
F
-----------
L
Y
L
Q
K
V
Y
D
L
F
K
E
K--------------------------------------------------------------------------YP-N
I
--
R
L
Q
K
Q
E
TAM
D
E
E
R
R
E
H
F
L
E
R
F
------
Q
AE
N
V
E
----
T
L
I
G
F
C
V
L
------
G
G
V
F
SEGVDLR-G
N
R
----
L
V
G
A
A
V
V
G
V
G
L
A
QLN-H----------------------------------
E
--------------------------------------
S
D
L
I
K
---
D
Y
Y
--
N
E
T
-I----------GR-GF
D
Y
A
YQIP
G
-
M
N
K
V
L
Q
A
V
G
R
V
--IR---GESD--R
G
---
V
V
L
L
----IEERFSADR
Y
R
A-LFPTH----WNHAKTVK
S
T
D
D
I
S
R
E
---------
V
A
---
G
F
WRNS------------------------------------------------
1
PsiBlast_PDB
89.35
23%
-90
- C6 -
2VSF
2
XPD_THEAC
A:
[10-591]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
P
T
-
G
S
G
K
T
I
M
A
L
------------
K
S
A
L
Q
Y
S
------------
S
E
R
-
K
L
K
V
L
Y
L
V
R
T
-
N
----
S
Q
E
E
Q
V
----
I
K
E
L
R
S
L
S
S
T
M
K
I
R
A
I
P
---
M
Q
G
R
V
N
M
C
I
L
-------
Y
R
---------
M
V
--
D
-
D
L
H
EIN
A
E
S
L
A
K
F
C
N
M
K
K
R
--
E
V
M
A
G
N
E
A
ACPYFNFKIRS
D
E
T
K
R
F
L
F
D
E
L
P
T
A
------
E
E
------------
F
Y
----------------
D
Y
G
--
E
R
N
N
V
C
P
Y
E
---------------------------
S
M
K
A
A
L
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
N
----
R
---------
S
V
A
E
K
F
L
S
H
W
G
--
V
----
S
R
NQ
I
V
I
------------------
I
L
D
E
A
H
N
L
P
D
I
----
G
R
S
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
------
Y
G
D
P
E
L
S
Q
K
I
H
V
---
S
D
L
I
E
M
I
R
S
A
L
----------
Q
S
M
V
S
E
R
CG
K
G
D
V
R
I
R
F
-
Q
E
F
----
M
E
Y
M
R
I
M
N
KRS
E
R
E
I
R
S
L
L
N
--
Y
L
--------------
Y
L
F
G
E
Y
V
--
E
N
E
-
K
E
K
V
G
K
V
P
F
S
Y
C
S
S
V
A
S
R
-----------------
I
I
-
A
F
S
D
Q
D
E
E
K
---
Y
A
A
I
L
S
P
E
D
G
---
G
Y
-
M
Q
A
A
C
L
--
D
P
--------
S
G
I
L
-
E
V
L
K
-
E
S
K
T
I
H
M
S
G
T
L
D
P
-
F
---------
D
F
Y
S
D
I
-
T
G
---------
F
E
I
P
F
K
K
IGEIFPP
E
---
N
R
Y
I
A
Y
Y
D
G
V
S
S
K
Y
D
T
L
D
-
E
--
K
-
E
L
-
D
R
M
A
T
V
I
E
D
I
-----
I
L
K
V
K
K
N
T
I
V
Y
--------
F
P
S
---------------
Y
-----------
S
L
M
D
R
V
-----
E
N
--------------------------------------------------------------------------
R
V
-
S
F
--
E
H
M
K
E
Y
R
G
I
D
Q
K
E
L
Y
S
M
L
K
K
F
------
R
R
D
H
G
T
----
I
---
F
A
V
S
------
G
G
R
L
S
E
------
G
N
E
----
L
E
M
I
I
L
A
G
L
P
F
P
R
P
D
-
A
----------------------------------
I
--------------------------------------
N
R
S
L
F
---
D
Y
Y
--
E
R
K
-
Y
----------
G
K
-
G
W
E
Y
S
V
V
Y
P
T
-
A
I
K
I
R
Q
E
I
G
R
L
--
I
R
---
S
A
E
D
--
T
G
---
A
C
V
I
----
L
D
K
R
--
A
G
Q
F
R
K
-
F
I
P
-----------
D
M
K
K
T
S
D
P
A
S
D
---------
I
Y
---
N
F
F
---------------------------------------------------
2
PsiBlast_PDB
88.64
23%
-91
- C6 -
4A15
6
XPD_THEAC
A:
[28-609]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
P
T
-
G
S
G
K
T
I
M
A
L
------------
K
S
A
L
Q
Y
S
------------
S
E
R
-
K
L
K
V
L
Y
L
V
R
T
-
N
----
S
Q
E
E
Q
V
----
I
K
E
L
R
S
L
S
S
T
M
K
I
R
A
I
P
---
M
Q
G
R
V
N
M
C
I
L
-------
Y
R
---------
M
V
--
D
-
D
L
H
EIN
A
E
S
L
A
K
F
C
N
M
K
K
R
--
E
V
M
A
G
N
E
A
ACPYFNFKIRS
D
E
T
K
R
F
L
F
D
E
L
P
T
A
------
E
E
------------
F
Y
----------------
D
Y
G
--
E
R
N
N
V
C
P
Y
E
---------------------------
S
M
K
A
A
L
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
N
----
R
---------
S
V
A
E
K
F
L
S
H
W
G
--
V
----
S
R
NQ
I
V
I
------------------
I
L
D
E
A
H
N
L
P
D
I
----
G
R
S
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
------
Y
G
D
P
E
L
S
Q
K
I
H
V
---
S
D
L
I
E
M
I
R
S
A
L
----------
Q
S
M
V
S
E
RCG
K
G
D
V
R
I
R
F
-
Q
E
F
----
M
E
Y
M
R
I
M
N
KRS
E
R
E
I
R
S
L
L
N
--
Y
L
--------------
Y
L
F
G
E
Y
V
--
E
N
E
-
K
E
K
V
G
K
V
P
F
S
Y
C
S
S
V
A
S
R
-----------------
I
I
-
A
F
S
D
Q
D
E
E
K
---
Y
A
A
I
L
S
P
E
D
G
---
G
Y
-
M
Q
A
A
C
L
--
D
P
--------
S
G
I
L
-
E
V
L
K
-
E
S
K
T
I
H
M
S
G
T
L
D
P
-
F
---------
D
F
Y
S
D
I
-
T
G
---------
F
E
I
P
F
K
K
IGEIFPP
E
---
N
R
Y
I
A
Y
Y
D
G
V
-------
D
-
E
--
K
-
E
L
-
D
R
M
A
T
V
I
E
D
I
-----
I
L
K
V
K
K
N
T
I
V
Y
--------
F
P
S
---------------
Y
-----------
S
L
M
D
R
V
-----
E
N
--------------------------------------------------------------------------
R
V
-
S
F
--
E
H
M
K
E
Y
R
G
I
D
Q
K
E
L
Y
S
M
L
K
K
F
------
R
R
D
H
G
T
----
I
---
F
A
V
S
------
G
G
R
L
---------
N
E
----
L
E
M
I
I
L
A
G
L
P
F
P
R
P
D
-
A
----------------------------------
I
--------------------------------------
N
R
S
L
F
---
D
Y
Y
--
E
R
K
-
Y
----------
G
K
-
G
W
E
Y
S
V
V
Y
P
T
-
A
I
K
I
R
Q
E
I
G
R
L
--
I
R
---
S
A
E
D
--
T
G
---
A
C
V
I
----
L
D
K
R
--
A
G
Q
F
R
K
-
F
I
P
-----------
D
M
K
K
T
S
D
P
A
S
D
---------
I
Y
---
N
F
F
---------------------------------------------------
42
Fugue
87.32
20%
-81
- C6 -
2VSF
2
XPD_THEAC
A:
[5-597]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
V
A
-----
L
E
S
P
T
-
G
S
G
K
T
I
M
A
L
------------
K
S
A
L
Q
Y
S
------------
S
E
R
-
K
L
-
K
V
L
Y
L
V
R
-
T
----
N
S
Q
E
E
Q
V
I
K
E
L
R
S
L
S
---
S
T
M
K
I
R
A
I
P
---
M
Q
G
R
V
N
M
C
I
L
------
Y
R
M
V
DDLHEIN
A
E
S
--
L
-
A
K
F
----------
C
N
M
K
K
R
--
E
V
M
A
G
N
E
A
-----------------
A
C
P
Y
F
N
F
K
------
I
R
S
D
E
T
K
R
F
L
FDEL
P
T
A
-----------
E
E
F
Y
D
Y
G
--
E
R
N
N
V
C
P
Y
E
S
--------------------------
M
K
A
A
L
P
D
-
A
D
I
V
I
A
P
Y
A
Y
F
L
N
----
R
---------
S
V
A
E
K
F
L
S
H
W
G
VS
R
----
N
Q
--
I
V
I
------------------
I
L
D
E
A
H
N
L
P
D
I
----
G
R
S
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
Y
GDPEL
S
Q
K
I
H
V
S
D
L
I
E
M
-
I
R
S
A
L
Q
S
M
V
S
E
-
R
CGK
G
D
V
R
I
R
F
Q
E
F
------
M
E
Y
M
R
I
M
N
-
K
R
S
----
E
R
E
I
R
-----------
S
L
L
N
--
Y
L
--------------
Y
L
F
G
E
Y
V
E
N
E
K
E
-
K
V
G
K
V
P
F
S
Y
C
S
S
V
A
S
--
R
-----------------
I
I
-
A
F
S
D
Q
D
E
E
K
---
Y
A
A
I
L
S
P
E
-
D
---
G
G
Y
M
Q
A
A
C
L
--
D
P
--------
S
G
I
L
E
V
L
K
E
--
S
K
T
I
H
M
S
G
T
L
D
P
-
F
---------
D
F
Y
S
D
I
-
T
G
F
--
E
I
P
F
K
K
I
G
E
I
F
P
P
-------
E
---
N
R
Y
I
A
Y
Y
D
G
V
S
S
K
Y
D
-
T
L
D
E
--
K
-
E
L
-
D
R
M
A
T
V
I
E
D
I
-----
I
L
K
V
K
K
N
T
I
V
Y
--------
F
P
S
---------------
Y
-----------
S
L
M
D
R
V
E
N
R
V
S
F
E
----------------------------------------------------------------------------------
H
M
K
E
Y
R
G
I
D
Q
K
E
L
Y
S
M
L
K
K
F
------
R
R
D
H
G
-------
T
I
F
A
V
S
------
G
G
R
L
S
E
G
N
E
L
E
----------
M
I
I
L
A
G
L
P
F
P
R
P
D
-
A
----------------------------------
I
--------------------------------------
N
R
S
L
F
---
D
Y
Y
--
E
R
K
-
Y
----------
G
K
-
G
W
E
Y
S
V
V
Y
P
T
-
A
I
K
I
R
Q
E
I
G
R
L
--
I
R
---
S
A
E
D
--
T
G
---
A
C
V
I
----
L
D
K
R
A
--
G
Q
F
R
K
-
F
I
P
D
-----------
M
K
K
T
S
D
P
A
S
D
---------
I
Y
---
N
F
F
I
S
A
Q
AR---------------------------------------------
3
PsiBlast_PDB
80.43
20%
-79
- C6 -
3CRV
10
XPD_SULAC
A:
[5-534]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
-----------------
W
Q
E
K
L
K
D
K
-
V
I
E
-----
G
L
R
N
N
--
F
L
V
A
-----
L
N
A
P
T
-
G
S
G
K
T
L
F
S
L
------------
L
V
S
L
----------------
E
V
-
K
P
K
V
L
F
V
V
R
T
-
H
----
N
E
F
Y
P
I
Y
R
D
-
L
T
K
I
R
E
--
K
----
R
N
I
T
F
S
F
L
V
G
K
P
S
S
C
L
Y
------
A
E
K
---------
G
A
--
E
-
S
E
D
IP--------
C
K
Y
C
E
-------
L
K
G
S
-----------------
I
V
E
V
K
T
D
D
------
S
P
------------
L
S
L
V
----------
K
K
L
K
K
D
G
--
L
Q
D
K
F
C
P
Y
Y
S
--------------------------
L
L
N
S
L
Y
K
-
A
D
V
I
A
L
T
Y
P
Y
F
F
---------------
I
D
R
Y
R
E
F
I
D
I
D
--
L
----
R
E
--
Y
M
I
------------------
V
I
D
E
A
H
N
L
-
D
K
----
V
N
E
L
E
E
R
S
L
S
E
I
T
I
Q
M
A
I
K
Q
S
K
S
------
E
E
S
R
R
I
L
S
K
L
L
N
-
Q
L
R
E
V
V
L
P
D
E
K
-
Y
----------
I
K
V
------
E
N
V
P
K
L
S
K
-
E
E
L
--------------------
E
I
L
A
D
D
Y
E
--------------
D
I
R
K
D
S
L
K
Q
G
K
V
-
N
K
I
H
I
G
S
I
L
R
F
F
S
L
L
-----------------------
S
I
G
S
F
I
P
F
S
---
Y
S
K
R
L
V
I
K
N
P
---
E
I
S
Y
Y
L
N
L
L
--
N
D
--------
N
E
L
---------
S
I
I
L
M
S
G
T
L
P
P
-
R
---------
E
Y
M
E
K
V
-
W
G
I
K
R
N
M
L
Y
L
D
V
E
R
E
I
Q
K
-------
R
V
S
G
S
Y
E
C
Y
I
G
V
D
V
T
S
K
Y
D
-
M
R
-
S
--
D
-
N
M
W
K
R
Y
A
D
Y
L
L
K
I
-----
Y
F
Q
A
K
A
N
V
L
V
V
--------
F
P
S
---------------
Y
-----------
E
I
M
D
R
V
M
S
--------------------------------------------------------------------------------------
R
I
S
L
P
K
Y
V
E
S
E
D
S
S
V
E
D
L
Y
S
A
------
I
S
A
N
N
K
----
V
L
I
G
-
S
V
G
------
K
G
K
L
A
E
G
I
E
L
R
-
N
N
D
RSL-
I
S
D
V
V
I
V
G
I
P
Y
P
P
P
D
-
D
----------------------------------
Y
--------------------------------------
L
K
I
L
A
---
Q
R
V
--
S
L
K
-
M
----------
N
R
E
N
E
E
F
L
F
K
I
P
A
-
L
V
T
I
K
Q
A
I
G
R
A
--
I
R
---
D
V
N
D
--
K
C
---
N
V
W
L
----
L
D
K
R
F
E
S
---------------------------------------------------------------------------------------------------
15
HHSearch
76.85
17%
-75
- C6 -
3CRV
10
XPD_SULAC
A:
[3-546]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
D
-----------------
W
Q
E
K
L
K
D
K
-
V
I
E
-----
G
L
R
N
N
--
F
L
V
A
-----
L
N
A
P
T
-
G
S
G
K
T
L
F
S
L
------------
L
V
S
L
E
------------------
V
K
P
K
V
L
F
V
V
R
-
T
----
H
N
E
F
Y
P
I
Y
R
D
L
T
K
I
R
E
---
K
R
N
I
T
F
S
F
---
L
V
G
K
P
S
S
C
L
Y
------
A
E
K
---------
G
A
ES
E
-
D
I
P
----------
C
K
Y
C
E
L
--
K
G
S
-
I
V
E
V
--------------------
K
T
D
D
S
------
P
L
------------
S
L
V
-----------
K
K
L
K
K
D
G
--
L
Q
D
K
F
C
P
Y
Y
S
--------------------------
L
L
N
S
L
Y
K
-
A
D
V
I
A
L
T
Y
P
Y
F
F
I
----
D
---------
R
Y
R
E
F
--
I
D
I
D
--
L
----
R
E
--
Y
M
I
------------------
V
I
D
E
A
H
N
L
D
K
V
-----
N
E
L
E
E
R
S
L
S
E
I
T
I
Q
M
A
I
K
Q
S
K
S
------
E
E
---
S
R
R
I
L
S
K
-
L
L
N
Q
L
R
E
V
V
L
P
-
D
----------
E
K
----------
Y
I
K
V
E
-
N
V
P
----
K
L
S
K
E
-----------
E
L
E
I
--
L
A
--------------
D
D
Y
E
D
I
R
K
D
S
L
K
Q
G
K
V
N
K
---
I
H
I
G
S
I
L
--
R
-----------------
F
F
-
S
L
L
S
I
--
G
S
---
F
I
P
F
S
Y
-------
S
K
R
L
V
I
K
N
P
--
E
I
--------
S
Y
Y
L
N
L
L
N
D
N
E
L
S
I
I
L
M
S
G
T
L
P
P
-
R
---------
E
Y
M
E
K
V
-
W
G
I
K
R
N
M
L
Y
L
D
V
E
R
E
I
Q
K
RV
S
----
G
---
S
Y
E
C
Y
I
G
V
D
V
T
S
K
Y
D
-
M
R
-
S
--
D
N
M
W
-
K
R
Y
A
D
Y
L
L
K
I
-----
Y
F
Q
A
K
A
N
V
L
V
V
--------
F
P
S
---------------
Y
-----------
E
I
M
D
R
V
M
S
R
I
S
L
----------------------------------------------------------------------------------
P
K
Y
V
E
S
E
---
D
S
S
V
E
D
L
Y
S
A
I
------
S
A
N
--
N
----
K
V
L
I
G
S
V
G
------
K
G
K
L
A
E
G
I
E
L
R
-
N
N
D
RSL-
I
S
D
V
V
I
V
G
I
P
Y
P
P
P
D
-
D
----------------------------------
Y
--------------------------------------
L
K
I
L
A
---
Q
R
V
--
S
L
K
M
N
----------
R
E
-
N
E
E
F
L
F
K
I
P
A
-
L
V
T
I
K
Q
A
I
G
R
A
--
I
R
---
D
V
N
D
--
K
C
---
N
V
W
L
----
L
D
K
R
F
E
S
-
L
Y
W
K
-
K
N
L
K
C
----
L
N
A
---------------------------------------------------------------------------------
41
Fugue
68.86
16%
-74
- C6 -
2VL7
1
?
A:
[9-540]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
-----------------
W
Q
A
E
K
L
G
E
-
A
I
N
-----
A
L
K
H
G
--
K
T
L
L
-----
L
N
A
K
P
-
G
L
G
K
T
V
F
V
E
------------
V
L
G
M
Q
L
------------------------------------------------------------------
K
K
K
V
L
I
F
------
T
R
----------------------------------------------------------------------------
T
H
------------
S
Q
L
-----------
D
S
I
Y
K
N
A
--
K
L
L
G
L
K
T
G
F
L
---------------------------
R
A
N
L
K
D
-
K
D
V
I
A
M
T
Y
P
Y
L
F
Q
----
K
---------
P
I
R
N
S
V
F
C
N
K
D
--
D
CLKL
E
D
--
Y
L
I
------------------
V
I
D
E
A
H
N
L
L
E
-----
A
D
K
W
F
T
R
K
I
S
R
K
M
L
E
R
A
L
K
E
I
E
I
------
V
E
R
L
N
R
-
I
D
A
K
K
-
V
K
D
Y
I
N
L
L
I
D
Y
-
M
----------
S
K
L
------
I
K
D
G
R
C
H
E
-
L
S
L
----
M
--
P
L
-----------
P
D
R
E
--
T
N
--------------
G
E
L
I
V
V
T
R
A
Y
L
N
-
I
D
------
E
G
P
V
K
K
S
--
S
-----------------
L
K
-
S
L
L
K
F
V
E
M
K
---
G
D
L
Y
N
C
-------
N
G
S
L
V
K
V
P
S
--
D
V
--------
N
Q
L
I
E
D
A
L
N
V
K
T
F
K
V
L
M
S
G
T
L
P
E
-
S
---------
L
T
L
T
N
----------
S
Y
K
I
V
V
N
E
S
G
-------
R
---
G
-
E
Y
Y
Y
C
P
N
V
T
S
E
L
R
-
K
R
-
N
--
S
-
N
I
-
P
I
Y
S
I
L
L
K
R
I
-----
Y
E
N
S
S
K
S
V
L
V
F
--------
F
P
S
---------------
Y
-----------
E
M
L
E
S
V
R
I
H
L
S
G
I
------------------------------------------------------------------------------------------------
P
V
I
E
E
N
------
K
K
T
R
H
E
----
E
V
L
E
L
M
K
T
------
G
K
Y
L
V
M
L
V
M
L
-----------
F
E
S
L
V
L
A
G
L
P
Y
P
N
-
V
----------------------------------
S
--------------------------------------
D
D
M
V
R
K
R
I
E
R
L
--
S
K
L
-
T
----------
G
K
-
D
E
D
S
I
I
H
D
L
T
-
A
I
V
I
K
Q
T
I
G
R
A
--
F
R
---
D
P
N
D
--
Y
V
---
K
I
Y
L
----
C
D
S
R
Y
R
E
Y
F
A
D
L
G
I
S
E
K
E
----
I
K
L
F
A
-------------------------------------------------------------------------------
43
Fugue
64.65
19%
-47
- C3 -
4M5D
14
UTP22_YEAST
A:
[81-1237]
T
A
T
E
S
Y
D
I
H
I
A
R
E
T
A
E
L
F
K
S
N
I
F
K
L
Q
I
D
E
L
L
E
Q
V
KLK
Q
K
H
V
L
K
V
E
--
K
F
L
H
K
L
Y
D
I
L
Q
E
I
P
D
W
E
E
K
S
L
A
E
V
D
S
F
F
K
N
K
I
V
S
V
P
F
V
D
P
K
P
I
P
Q
N
T
N
Y
K
F
N
Y
K
K
P
D
I
S
L
I
G
S
F
A
L
K
A
-
G
I
Y
QP
N
-
G
S
S
I
D
T
L
L
T
M
P
--
K
E
L
F
E
K
K
D
FL
N
F
R
C
L
H
K
R
S
V
Y
L
A
Y
--
L
T
H
H
L
L
I
L
L
K
K
D
K
-
L
D
S
F
L
Q
L
E
Y
S
Y
F
DNDPL
L
P
I
L
R
I
S
C
S
K
D
Y
N
F
-----
Y
-----
K
TR
F
S
I
N
L
L
I
G
F
P
YK
V
F
E
P
K
K
L
LPNRNCIRILPAT
P
L
Y
N
F
S
V
L
--
S
S
S
T
H
E
N
Y
L
K
Y
L
Y
K
T
K
K
Q
T
E
S
---
F
V
E
A
---
T
V
L
G
R
L
W
L
Q
Q
R
GFSSNMSHSGSLGGF
G
T
F
E
F
T
I
L
-
M
A
A
L
L
N
GG
G
I
N
S
N
--
K
I
L
L
HGFS
S
Y
Q
L
F
K
-
G
V
I
K
Y
L
A
T
M
DLCHD
G
H
L
Q
F
H
S
N
P
A
S
K
Y
I
------------
D
E
G
F
Q
T
P
T
L
F
D
K
S
T
-
K
VNIL
T
K
M
T
V
S
S
Y
Q
I
L
K
E
Y
A
G
--
E
T
L
R
M
L
N
N
V
---
V
Q
D
Q
F
S
N
I
F
L
TNISRF
D
N
L
---------
K
Y
--
D
L
C
Y
D
----------
V
Q
L
P
L
G
--
K
Y
N
N
L
E
T
S
-----------------
L
A
A
T
F
G
S
M
------
E
R
------------
V
K
F
IT
L
E
N
F
L
A
H
K
I
T
N
V
A
R
Y
A
L
G
D
R
I
K
Y
I
Q
I
E
M
VGQKSDFPITKRKVYSNTGGNHFNFD
F
V
R
V
K
L
I
-
V
N
P
S
E
C
D
K
L
V
T
K
G
----
P
AHSETMS
T
E
A
A
V
F
K
N
F
W
G
I
K
--
S
----
S
L
--
R
R
F
KDG
S
I
T
H
C
C
V
W
S
T
S
SSEP
I
I
S
S
I
V
N
F
A
L
Q
----
K
H
V
S
K
K
A
Q
I
S
N
E
T
I
K
K
F
H
N
F
L
P
L
------
P
N
L
P
S
S
A
K
T
S
V
L
-
N
L
S
S
F
F
N
L
K
K
S
-
F
----------
D
D
L
------
Y
K
I
I
F
Q
M
K
-
L
P
L
SVK
S
I
L
P
V
G
-----------
S
A
F
R
--
Y
T
SLCQPVPFAYSDPD
F
F
Q
D
V
I
L
E
F
E
T
S
-
P
K
W
P
D
E
I
T
S
L
E
K
A
K
T
--
A
-----------------
F
L
L
K
I
Q
E
E
L
S
A
N
SST
Y
R
S
F
F
S
R
D
E
S
IPY
N
L
E
I
V
T
L
N
I
L
T
P
E
--------
G
Y
G
F
K
F
R
V
L
T
E
R
D
E
I
L
Y
---
L
R
A
-
I
---------
A
N
A
R
N
E
-
L
K
P
E
L
E
A
T
F
L
K
F
T
A
K
Y
L
A
-------
S
---
V
R
H
T
R
T
L
E
N
I
S
H
S
Y
Q
-
F
Y
-
S
--
P
-
V
V
-
R
L
F
K
R
W
L
D
T
H
LLLGH
I
T
D
E
L
A
E
L
I
A
I
--------
K
P
F
VDPAPYFIPGS
L
E
N
G
F
-----------
L
K
V
L
K
F
I
S
Q
W
N
W
K
--------------------------------------------------------------------------
D
D
-
P
L
I
L
D
L
V
K
P
E
E
R
L
T
L
A
Q
Y
K
G
I
Q
M
N
F
------
T
N
L
R
N
S
DPNG
T
H
L
Q
F
F
V
A
SKNDPS
G
I
L
Y
S
S
G
I
P
L
P
I
A
T
R
----
L
T
A
L
A
K
V
A
V
N
L
L
Q
T
H
-
G
----------------------------------
L
--------------------------------------
N
Q
Q
T
I
---
N
L
L
--
F
T
P
-
G
----------
L
K
-
D
Y
D
F
V
V
D
L
R
T
-
P
I
G
L
K
S
S
C
G
-
I
--
L
S
---
A
P
S
N
FP
E
N
---
L
N
D
L
----
S
E
K
M
D
P
T
Y
Q
L
V
K
-
Y
L
N
L
K
----
Y
K
N
S
L
I
L
S
S
R
K
Y
I
G
V
N
GGEKGD
K
N
V
I
T
---
G
L
I
K
P
L
FK
G
A
H
K
FRVNLDCNVKPVDDENVILN
K
E
A
I
F
H
E
I
A
A
F
G
NDMVI
N
F
E
T
D
44
Fugue
60.41
16%
-46
* C5 *
2QYU
2
SOPA_SALTY
A:
[8-627]
------------------------------------ATSS
P
S
S
P
A
--
D
W
A
K
K
L
T
D
A
V
L
R
Q
K
A
-
G
E
T
-
L
T
A
A
D
R
D
F
S
N
A
D
F
R
N
I
---
T
F
S
K
I
L
P
P
S
F
M
E
R
D
G
D
I
I
K
G
F
N
F
S
N
S
K
F
T
Y
S
D
I
--
S
-
H
L
H
F
D
E
C
R
F
T
Y
--
S
T
L
S
D
V
V
---------------------
C
S
N
T
K
F
S
-
N
S
D
-
M
N
E
-
V
F
L
Q
Y
S
I
------------------------------------------------
T
T
Q
Q
Q
-------------
P
S
F
I
D
T
T
L
--
K
N
T
L
I
R
H
K
A
-----------
N
---
L
S
G
V
---
I
L
N
E
P
D
N
S
S
-----------------
P
P
S
V
S
G
G
G
-
N
F
I
-----
R
L
G
D
-------------------
I
W
L
Q
M
P
L
L
------------
W
----------------------------------------
T
E
N
A
V
D
G
F
L
N
H
E
H
N
--
N
G
---
K
S
I
L
---
M
T
I
D
--------------------------------------------
S
L
P
D
K
--
Y
S
Q
E
K
V
Q
A
-----------------
M
E
D
L
V
K
S
L
R
G
GRLT
E
A
------------
C
I
R
-----------
P
V
E
S
S
L
V
--
S
V
L
A
H
P
P
Y
T
Q
--------------------------
S
-----------------------------------
A
L
I
S
E
W
L
G
P
V
--
Q
----
E
R
--
F
F
A
------------------
H
Q
C
Q
T
Y
N
D
V
P
-------------------------
L
P
A
------
P
D
T
Y
Y
Q
Q
R
I
L
P
V
-
L
L
D
S
F
D
R
N
S
A
A
-
M
----------
T
T
--------------
H
-
S
G
L
------
F
N
Q
-----------
V
I
L
H
--
C
M
--------------
T
------
G
V
D
C
T
-
D
G
T
R
Q
K
A
A
A
L
Y
E
Q
Y
L
--
A
-----------------
H
P
-
A
V
S
P
H
I
H
N
G
---
L
F
G
N
Y
D
G
S
P
----
D
W
T
T
R
A
-----
A
D
--------
N
F
L
L
L
S
S
Q
D
S
D
T
A
M
M
L
S
T
D
T
L
L
T
-
M
L
N
PTPDTAW
D
N
F
Y
L
L
-
R
A
G
E
N
V
S
T
A
Q
I
S
P
V
E
L
F
R
-------
H
---
D
F
P
V
F
L
A
A
F
---
N
Q
Q
-
A
T
-
Q
--
R
-
R
F
-
G
E
L
I
D
I
I
L
S
T
-----
E
E
H
G
E
L
N
Q
Q
F
L
--------
A
A
T
---------------
N
Q
KHSTVKLID
D
A
S
V
S
R
L
A
T
I
F
D
P
L
--------------------------------------------------------------------------
L
P
----------
E
G
K
L
S
P
A
H
Y
Q
H
I
L
S
A
Y
HLTDAT
P
Q
K
Q
A
E
----
T
L
F
C
L
S
T
A
------
F
A
R
Y
S
S
S
A
I
F
G
-
T
E
H
----
D
S
P
P
A
L
R
G
Y
A
E
A
L
M
Q
-
K
----------------------------------
A
--------------------------------------
W
E
L
S
P
---
A
I
F
PS
S
E
Q
-
F
----------
T
E
-
W
S
D
R
F
H
G
L
H
G
-
A
F
T
C
T
S
V
V
A
D
S
--
M
Q
---
R
H
A
R
--
K
Y
---
F
-------------
P
S
V
L
S
S
-
I
L
P
L
A
----
W
A
----------------------------------------------------------------------------------
47
Fugue
56.63
16%
-21
- C2 -
4IUW
16
?
A:
[4-633]
----------------------------------------
L
P
R
I
Q
DD
L
Y
L
A
V
N
G
E
W
Q
A
K
T
P
I
P
P
D
K
-
S
V
V
S
A
D
S
N
L
T
D
D
I
R
Q
K
L
V
A
D
L
S
T
M
T
K
T
A
K
T
L
P
L
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Y
A
A
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L
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A
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A
N
D
Q
T
R
R
Q
Q
L
--
G
I
E
P
V
R
D
R
I
S
F
L
M
A
L
T
T
L
D
Q
F
R
S
--
A
M
P
K
L
V
-----
A
D
Q
YV
L
P
I
S
P
Y
V
D
A
D
M
H
D
-
A
E
H
-
N
I
L
N
L
G
G
P
---------
D
T
I
L
P
D
A
A
M
Y
N
Q
ED
A
E
-----
N
--------------
A
A
D
L
A
A
W
-------------
S
Q
M
A
A
A
M
L
--
A
A
----
V
G
F
S
Q
T
D
Q
T
A
Y
V
-
E
A
---
A
K
R
F
---
D
R
R
L
A
D
Y
V
P
-----------------
A
N
V
D
L
A
V
D
S
T
Y
D
-----
N
P
L
S
W
--
Q
A
F
E
-----
D
A
A
G
Y
L
G
I
P
Q
A
F
A
T
Y
------------
M
P
Q
T
P
A
K
------------
V
N
A
-
V
V
P
A
Y
L
P
H
L
S
-
K
----
L
L
T
P
D
N
Y
S
E
W
H
A
W
M
V
I
--
N
E
L
L
T
C
A
T
Y
---
L
S
-------
D
------
D
L
R
---------
Q
L
--
A
-
G
Q
Y
----------
D
R
F
L
A
G
--
Q
P
E
A
S
S
W
T
-----------------
K
H
A
F
G
I
A
N
------
E
Y
------------
F
D
D
-----------
V
I
G
Q
Y
Y
G
--
Q
T
Y
--
F
G
A
D
A
--------------------------
K
A
D
V
T
A
M
-
V
K
Q
I
L
A
Q
Y
R
V
Q
L
E
----
N
---------
N
T
W
L
S
------------------------------------------------------
P
A
T
K
Q
K
A
M
R
K
L
A
T
M
Q
V
K
M
G
Y
P
A
------
R
L
F
-
S
L
Y
D
H
L
S
V
D
V
D
D
D
L
L
T
A
I
L
K
-
L
----------
S
A
Q
------
T
Q
A
F
W
F
K
Q
L
G
Q
T
----
V
D
R
N
Q
-----------
W
N
M
-----------------------------------------------------------------------------------------------------------
P
--------
G
H
L
V
N
A
S
Y
D
P
L
K
N
D
I
T
F
P
A
G
I
L
Q
-
P
---------
P
Y
Y
S
L
K
-
W
T
R
A
E
N
L
G
G
T
--
G
A
T
I
G
H
-------
E
---
I
S
H
S
F
--
D
N
N
G
A
L
Y
D
------------------------------
E
Y
G
N
L
H
N
W
--------
W
T
-----------------------------------------------------------------------------------------------------------------------------
P
A
D
K
Q
A
F
D
Q
L
V
K
A
M
A
A
Q
F
------
D
G
R
D
Y
E
-------------------
G
V
K
V
N
G
T
L
T
V
-
S
E
N
----
M
A
D
N
A
G
M
D
V
A
L
A
L
L
G
-
D
----------------------------------
Q
--------------------------------------
P
D
------------------------------------
V
K
D
-
L
Q
A
F
F
I
T
Y
A
R
S
W
A
T
K
---
M
R
P
E
--
R
A
---
K
T
V
L
----
R
Q
D
V
H
A
P
A
T
L
R
V
-
N
V
P
V
Q
N
F
P
A
W
Y
Q
A
F
N
V
Q
P
Q
D
G
M
Y
R
Q
---------
P
Q
K
R
L
T
I
W
H
Q
-------------------------------------------------
45
Fugue
54.62
14%
-39
- C4 -
4ZUZ
-
?
A:
[7-863]
-----------------------------------------
D
V
I
K
--
F
K
E
P
E
R
C
D
Y
L
Y
V
D
---------------
E
N
N
K
V
H
I
L
L
P
I
V
G
G
D
E
I
G
L
D
--
N
T
C
Q
T
A
V
E
L
I
T
F
F
Y
G
S
A
H
S
G
V
T
--
K
-
Y
S
A
E
H
Q
L
S
E
Y
K
--
R
Q
L
E
E
D
I
K
--
A
I
N
S
Q
K
-----
K
I
S
--
P
H
A
Y
D
D
L
L
K
E
K
I
E
R
L
Q
Q
-
I
E
K
Y
I
E
L
I
---------
Q
V
L
K
K
Q
Y
D
E
Q
-----
N
D
I
R
Q
L
R
--------------
T
G
G
I
P
Q
L
-------------
P
S
G
V
K
E
I
I
K
S
S
E
N
A
F
A
V
R
L
S
P
Y
D
N
D
K
F
T
-
R
F
DDP
L
F
N
V
---
K
R
N
I
S
K
Y
D
T
-----------------
P
S
R
Q
A
P
I
P
-
I
Y
E
-----
G
L
G
Y
R
L
R
S
T
L
F
-----
P
E
D
K
T
-
P
T
P
I
N
K
K
S
L
------------
R
D
K
V
K
S
T
V
L
S
HYKDEDRID
G
E
K
-
K
D
E
K
L
------
N
----
E
L
I
T
N
L
Q
N
E
L
V
K
E
L
V
K
--
S
D
P
Q
Y
S
K
L
S
---
L
S
K
D
P
R
G
K
E
I
------
N
Y
D
---------
Y
L
--
V
-
N
S
L
----------
M
L
V
D
N
D
SE
I
G
D
W
I
D
T
I
-----------------
L
D
A
T
V
D
S
T
------
V
W
------------
A
V
Q
-----------
A
S
S
P
F
Y
Q
--
G
A
K
E
I
S
S
D
R
D
--------------------------
A
D
K
I
S
I
R
-
V
Q
Y
L
L
A
E
A
N
I
Y
C
K
T
N
KL
S
---------
D
A
N
F
G
E
F
F
D
K
E
--
P
-----
H
--
A
T
E
------------------
I
A
K
R
V
K
E
G
F
T
Q
GAD
I
E
P
I
I
Y
D
Y
I
N
S
N
H
A
E
L
G
L
K
S
P
L
T
G
------
K
Q
Q
Q
E
I
T
D
K
F
T
K
-
H
Y
N
T
I
----
K
E
-
S
----------
P
H
F
------
D
E
F
F
V
A
D
P
-
D
K
K
----
G
N
I
F
S
-----------
H
Q
G
R
--
I
S
--------------
C
H
F
L
D
F
F
T
R
Q
T
K
-
G
K
H
P
L
G
D
L
A
S
H
Q
E
A
L
--
Q
E
GTSNRLHHKN
E
V
V
A
Q
G
Y
E
-
K
L
D
Q
F
--
K
K
---
E
V
V
K
L
L
A
E
N
K
---
P
K
E
L
L
D
Y
L
V
--
A
T
SPTGVPNY
S
M
L
S
K
E
T
Q
N
Y
I
A
Y
N
R
N
W
P
A
I
Q
K
E
-
L
---------
E
K
A
T
S
I
P
E
S
Q
K
Q
D
L
S
R
L
L
S
R
D
N
L
Q
H
-------
D
---
N
L
S
A
I
T
W
S
K
Y
S
S
K
P
L
-
L
D
-
V
E
L
N
-
K
I
-
A
E
G
L
E
L
T
A
K
I
-----
Y
N
E
K
R
G
R
E
W
W
F
AGSR
N
E
A
R
K
T
Q
---------------
C
-----------
E
E
L
Q
R
V
S
K
E
I
N
T
L
--------------------------------------------------------------------------
L
Q
-
S
E
--
S
L
T
K
S
Q
V
L
E
K
V
L
N
S
I
E
T
L
D
K
I
------
D
R
D
I
S
A
----
E
S
N
W
F
---------
Q
S
T
L
Q
K
E
V
R
L
F
-
R
D
Q
----
L
K
D
I
C
----
Q
L
D
K
Y
Y
-
F
----------------------------------
K
--------------------------------------
S
T
K
L
D
---
E
I
I
--
S
L
E
-
M
----------
E
E
-
Q
F
Q
-
K
I
Q
D
P
A
-
V
Q
Q
I
V
R
D
L
P
S
H
--
C
H
-----
N
D
--
E
A
---
I
E
F
F
K
T
L
N
P
E
E
A
A
K
V
A
S
Y
L
S
-
L
E
Y
R
E
----
I
N
--
K
S
T
D
K
K
T
L
L
E
Q
D
---------
I
P
---
R
L
F
K
E
V
N
T
Q
L
L
S
K
L
K
E
E
KAID
E
Q
V
H
E
K
L
S
Q
L
ADKIAPEHFT
R
N
N
I
I
K
W
S
T----
31
HHSearch
48.90
18%
-38
- C6 -
1GKU
-
RGYR_ARCFU
B:
[269-482]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
-----
L
E
K
L
G
T
G
G
I
I
Y
--------
A
R
T
---------------
G
-----------
E
E
A
E
E
I
Y
E
S
L
K
N
K
------------------------------------------------------------------------------
F
--
R
I
G
I
V
T
-----
A
T
K
K
G
D
Y
E
K
F
------
V
E
G
--
E
----
I
D
H
L
I
G
T
A
H----------
R
G
L
D
L
P
-
E
-
R
----
I
R
F
A
V
F
V
G
C
P
S
F
R
V
T
-
I
EDIDSLSPQMVKLLAYLYRNVDEIERLLPAVERH
I
--------------------------------------
D
E
V
R
E
---
I
L
K
--
K
V
M
-
G
KERPQAKDVV
V
R
-
E
G
--
E
V
I
F
P
D
-
L
R
T
Y
I
Q
G
S
G
R
T
--
S
R
LFA
G
G
L
T
--
K
G
---
A
S
F
L
----
L
E
D
D
S
E
L
---------------------------------------------------------------------------------------------------
29
HHSearch
48.56
21%
-55
- C6 -
2OCA
-
UVSW_BPT4
A:
[346-455]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
N
A
F
V
M
--------
F
K
H
---------------
V
-----------
S
H
G
K
A
I
F
D
L
I
K
N
E
--------------------------------------------------------------------------
Y
D
-----
K
V
Y
Y
V
S
G
E
V
D
T
E
T
R
-
N
I
M
K
T
L
------
A
E
N
-
G
K
----
G
I
I
I
V
A
S
-------
Y
G
V
F
S
T
G
I
S
V
K
-
N
------
L
H
H
V
V
L
A
H
G
V
K
S
------------------------------------------------------------------------------------------------------------------------
K
I
I
V
L
Q
T
I
G
R
V
--
L
R
---
K
H
G
S
--
K
T
---
I
A
T
V
----
W
D
L
I
------------------------------------------------------------------------------------------------------
26
HHSearch
45.02
14%
-43
- C6 -
2DB3
2
VASA1_DROME
A:
[297-407]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
A
D
G
T
I
V
F
--------
V
E
T
---------------
K
-----------
R
G
A
D
F
L
A
S
F
L
S
E
K
--------------------------------------------------------------------------
E
---
F
--
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
------
K
N
G
--
S
----
M
K
V
L
I
A
T
--------
S
V
A
S
R
G
L
D
I
K
-
N
------
I
K
H
V
I
N
Y
D
M
P
S
K
------------------------------------------------------------------------------------------------------------------------
I
D
D
Y
V
H
R
I
G
R
T
--
G
R
---
V
G
N
N
--
G
R
---
A
T
S
F
----
F
D
P
E
------------------------------------------------------------------------------------------------------
23
HHSearch
43.29
11%
-30
- C6 -
2V1X
2
RECQ1_HUMAN
A:
[266-349]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
Q
S
G
I
I
Y
--------
C
F
S
---------------
Q
-----------
K
D
S
E
Q
V
T
V
S
L
Q
N
L
--------------------------------------------------------------------------
G
---
I
--
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
------
S
A
N
--
E
----
I
Q
V
V
V
A
T
V
--------
A
F
G
M
G
I
D
K
P
-
D
------
V
R
F
V
I
H
H
S
M
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
43.12
14%
-49
- C6 -
1OYW
-
RECQ_ECOLI
A:
[235-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
K
S
G
I
I
Y
--------
C
N
S
---------------
R
-----------
A
K
V
E
D
T
A
A
R
L
Q
S
K
--------------------------------------------------------------------------
G
---
I
--
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
------
Q
R
D
--
D
----
L
Q
I
V
V
A
T
--------
V
A
F
G
M
G
I
N
K
P
-
N
------
V
R
F
V
V
H
F
D
I
P
R
N
------------------------------------------------------------------------------------------------------------------------
I
E
S
Y
Y
Q
E
T
G
R
A
--
G
R
---
D
G
L
P
--
A
E
---
A
M
L
F
----
Y
D
P
-------------------------------------------------------------------------------------------------------
24
HHSearch
42.84
19%
-52
- C6 -
3I5X
2
MS116_YEAST
A:
[339-420]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
K
A
I
I
F
--------
A
P
T
---------------
V
-----------
K
F
T
S
F
L
C
S
I
L
K
N
E
--------------------------------------------------------------------------
F
K
K
D
L
--
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
------
K
K
D
--
E
----
S
G
I
L
V
C
T
--------
D
V
G
A
R
G
M
D
F
P
-
N
------
V
H
E
V
L
Q
I
G
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
42.26
18%
-49
- C6 -
3SQW
2
MS116_YEAST
A:
[287-369]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
K
A
I
I
F
--------
A
P
T
---------------
V
-----------
K
F
T
S
F
L
C
S
I
L
K
N
E
--------------------------------------------------------------------------
F
K
K
D
L
--
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
------
K
K
D
--
E
----
S
G
I
L
V
C
T
--------
D
V
G
A
R
G
M
D
F
P
-
N
------
V
H
E
V
L
Q
I
G
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.83
27%
66
- C6 -
4F91
-
U520_HUMAN
B:
[1313-1392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
-
S
A
---
F
E
S
L
YQD
K
F
P
F
--
F
N
P
-----------------
I
Q
T
Q
V
F
N
T
-
V
Y
--------
N
S
D
--
D
N
V
F
-----
V
G
A
P
T
-
G
S
G
K
T
I
C
A
E
------------
F
A
I
L
R
M
L
------------
L
Q
S
-
S
E
G
R
C
V
Y
I
T
P
M
E
----
A
L
A
E
Q
V
Y
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
41.13
13%
-44
- C6 -
2IPC
-
SECA_THET8
A:
[372-707]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
F
F
R
L
Y
E
K
R
A
G
M
T
G
T
A
K
T
E
E
---------
K
E
F
Q
E
I
-
Y
G
M
D
V
----
V
V
V
P
T
N
R
P
V
-------
I
-----
R
K
D
F
P
D
V
---
V
Y
R
-
T
E
-
K
--
G
-
K
F
-
Y
A
V
V
E
E
I
A
E
K
-----
Y
-
E
R
G
Q
P
V
L
V
G
--------
T
I
S
---------------
I
-----------
E
K
S
E
R
L
S
Q
M
L
K
E
P
RLY
L
P
R
L
E
M
R
L
E
L
F
K
K
A
S
QKQQG
P
E
W
E
R
L
R
KLLERPAQLKDEDLAPFEGLIPPKG
N
L
R
T
A
W
E
G
L
K
R
A
V
H
T
L
A
V
L
R
Q
-
G
I
--
P
H
Q
V
L
N
A
K
H
H
A
R
E
A
E
I
V
A
Q
A
G
------
R
S
--------
K
T
V
T
I
A
T
--------
N
M
A
G
R
G
T
D
I
K
-
L
G
G
N
P
E
Y
L
A
A
A
L
L
E
K
E
G
F
D
R
Y
E
W
K
----------------------------------
V
E
L
F
I
K
K
M
V
A
GK
E
E
E
A
R
A
L
A
Q
E
L
GIR
E
E
L
L
E
R
I
R
E
I
R
E
E
C
K
Q
D
E
---
E
R
V
--
R
A
L
-
G
----------
G
L
-
F
I
-
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
--
G
R
---
Q
G
-
D
--
P
G
G
S
R
F
Y
V
S
----
F
D
D
D
L
M
R
L
F
A
S
-----------------------------------------------------------------------------------------------
21
HHSearch
40.23
16%
-33
- C6 -
1TF5
-
SECA_BACSU
A:
[414-494]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
-
K
A
V
A
E
D
V
A
Q
R
-----
Y
-
M
T
G
Q
P
V
L
V
G
--------
T
V
A
---------------
V
-----------
E
T
S
E
L
I
S
K
L
L
K
N
K
--------------------------------------------------------------------------
G
---
I
--
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
------
Q
K
--------
G
A
V
T
I
A
T
--------
N
M
A
G
R
G
T
D
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------