@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0158: (2016-03-12 )
MYKIIAIDIDGTLLNDTHEITPAVRDSIKAAKAKGVKVVLCTGRPLAGIKKSLIELDLLDEGDYAITFNGAVVLETASEKTLADITLNKTELEEIYAFCHAENVNVTYFDGKNMYVPSRKITEITCQDSLLLGTPLYHLPVEEAPESIHVSKVMLLDSPEKITDVIKKLPENIKEKFYVVRSVPYNLEFLQKGVNKGSALASLADKLGVDQSEVMSIGDQENDITMIEYAGMGVAMGNATEHIKEIANYTTTTNNEDGVAQAIQMLILDR
Atome Classification :
(21 SA)
.........10....-..-..20........30........40........50....--....60........70..---------------------------.....----.80...-.....90........100.-....-..110....-----..--.120.-----......-130----..-.-----------.-.----.---..--140-----.---....-----...150-----------...-.-...------160.--...------...170..-----.....180....---...190.......200.......210.......220.......230.......240......--.--250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
K
I
I
A
I
DIDGTLLN-DT-HEI
T
P
A
V
R
D
S
I
K
A
AKAK
G
V
K
V
V
L
CTGR
P
L
A
G
I
K
K
S
L
I
E
--
L
D
LLDEG
D
Y
A
I
T
FN
G
A
V
V
---------------------------
L
ETAS----E
K
T
L
A
D
-
I
TL
N
K
T
E
L
E
E
I
Y
A
F
C
HAEN-V
N
V
T
-
Y
FDGK
N
M
YV-----PS--R
K
I
T
E
-----
I
T
CQDS-
L
-
L
----LG-T-----------P-
L
----
Y
---HL--PV------E---EAPE-----SI
H
V
S
K
-----------
V
M
L-L-D
S
P
------
E
K
I
T
--
D
V
I
------
K
K
L
P
E
N
I
K
-----
E
K
F
Y
V
V
RSVPY
N
---
L
E
F
L
Q
K
GVNK
G
S
A
L
A
S
L
A
D
KLGV
D
Q
S
E
V
M
SIGDQEN
D
I
T
M
I
E
YAGM
G
V
AMG
N
A
T
E
H
I
K
E
I
AN--Y--TTTTNN
E
D
G
V
A
Q
A
I
Q
M
L
ILDR--
1
PsiBlast_PDB
93.24
44%
-103
* C1 *
1RKQ
2
YIDA_ECOLI
A:
[6-272]
--
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
-
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
--
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
---------------------------
Q
K
A
A
D
----
G
S
T
V
A
Q
-
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
V
G
-
S
H
F
H
-
A
L
D
R
T
T
L
Y
T
-----
A
N
--
R
D
I
S
Y
-----
Y
T
V
H
E
S
-
F
-
V
----
A
T
-
I
-----------
P
-
L
----
V
---
F
C
--
E
A
------
E
---
K
M
D
P
-----
N
T
Q
F
L
K
-----------
V
M
M
-
I
-
D
E
P
------
A
I
L
D
--
Q
A
I
------
A
R
I
P
Q
E
V
K
-----
E
K
Y
T
V
L
K
S
A
P
Y
F
---
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
--
F
--
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
N
---
21
PsiBlast_CBE
93.08
44%
-106
- C1 -
1RKQ
2
YIDA_ECOLI
B:
[6-272]
--
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
-
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
--
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
---------------------------
Q
K
A
A
D
----
G
S
T
V
A
Q
-
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
V
G
-
S
H
F
H
-
A
L
D
R
T
T
L
Y
T
-----
A
N
--
R
D
I
S
Y
-----
Y
T
V
H
E
S
-
F
-
V
----
A
T
-
I
-----------
P
-
L
----
V
---
F
C
--
E
A
------
E
---
K
M
D
P
-----
N
T
Q
F
L
K
-----------
V
M
M
-
I
-
D
E
P
------
A
I
L
D
--
Q
A
I
------
A
R
I
P
Q
E
V
K
-----
E
K
Y
T
V
L
K
S
A
P
Y
F
---
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
--
F
--
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
N
---
86
HHSearch
89.62
42%
-109
- C1 -
1RKQ
2
YIDA_ECOLI
A:
[4-272]
A
I
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
-
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
--
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
---------------------------
Q
K
A
A
D
----
G
S
T
V
A
Q
-
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
V
G
-
S
H
F
H
-
A
L
D
R
T
T
L
Y
T
-----
A
N
--
R
D
I
--------
S
Y
Y
T
V
H
E
-
S
F
V
AT
I
P
L
V
-----------
F
-
C
----
E
---
A
E
--
K
M
------
D
----
P
N
-------
T
Q
F
L
K
-----------
V
M
M
-
I
D
E
P
A
-------
I
L
D
--
Q
A
I
------
A
R
I
P
Q
E
V
K
-----
E
K
Y
T
V
L
K
S
A
P
Y
F
---
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
--
F
--
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
N
---
2
PsiBlast_PDB
83.11
31%
-110
- C1 -
4DW8
4
?
A:
[5-269]
-
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
-
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
E
--
L
R
M
N
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
---------------------------
I
N
W
E
S
----
K
E
M
M
Y
E
-
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
N
H
-
L
S
I
L
-
T
Y
D
G
A
E
I
-------------
V
T
E
-----
N
S
L
D
P
Y
-
V
-
Q
----
K
E
-
A
-----------
F
-
L
----
N
---
K
M
--
A
I
------
R
---
E
T
N
D
FLTDI
T
L
P
V
A
K
-----------
C
L
I
-
V
-
G
D
A
------
G
K
L
I
--
P
V
E
------
S
E
L
C
I
R
L
Q
-----
G
K
I
N
V
F
R
S
E
P
Y
F
---
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
--
Y
--
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
F
-----
3
PsiBlast_PDB
82.95
30%
-109
- C1 -
3NIW
2
?
A:
[5-269]
-
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
-
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
E
--
L
R
M
N
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
---------------------------
I
N
W
E
S
----
K
E
M
M
Y
E
-
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
N
H
-
L
S
I
L
-
T
Y
D
G
A
E
I
-------------
V
T
E
-----
N
S
L
D
P
Y
-
V
-
Q
----
K
E
-
A
-----------
F
-
L
----
N
---
K
M
--
A
I
------
R
---
E
T
N
D
FLTDI
T
L
P
V
A
K
-----------
C
L
I
-
V
-
G
D
A
------
G
K
L
I
--
P
V
E
------
S
E
L
C
I
R
L
Q
-----
G
K
I
N
V
F
R
S
E
P
Y
F
---
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
--
Y
--
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
F
-----
87
HHSearch
77.62
32%
-93
- C1 -
1NRW
3
YWPJ_BACSU
A:
[4-288]
-
M
K
L
I
A
I
D
L
D
G
T
L
L
N
-
S
K
-
H
Q
V
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
E
P
--
L
G
I
---
K
T
W
V
I
S
A
N
G
A
V
I
---------------------------
H
D
P
-
E
----
G
R
L
Y
H
H
-
E
T
I
D
K
K
R
A
Y
D
I
L
S
W
L
E
S
E
N
-
Y
Y
Y
E
-
V
F
T
G
S
A
I
Y
T
-----
P
Q
--
N
G
R
E
L
L
D
V
E
L
D
R
F
R
S
A
-
N
-
P
E---
A
D
-
L
S
V
L
K
Q
A
A
E
V
Q
Y
S
-
Q
SG
F
A
Y
---
I
N
--
S
F
------
Q
ELF
E
A
D
E
-----
P
I
D
F
Y
N
-----------
I
L
G
-
F
S
F
F
K
------
E
K
L
E
--
A
G
W
------
K
R
Y
-
E
H
A
E
------
D
L
T
L
V
S
S
A
E
H
N
---
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
--
A
--
V
T
L
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----
4
PsiBlast_PDB
77.57
29%
-80
- C1 -
1NRW
3
YWPJ_BACSU
A:
[5-288]
--
K
L
I
A
I
D
L
D
G
T
L
L
N
-
S
K
-
H
Q
V
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
E
P
--
L
G
I
---
K
T
W
V
I
S
A
N
G
A
V
I
---------------------------
H
D
P
E
G
-----
R
L
Y
H
H
-
E
T
I
D
K
K
R
A
Y
D
I
L
S
W
L
E
S
E
N
-
Y
Y
Y
E
-
V
F
T
G
S
A
I
Y
T
-----
P
Q
N
G
R
E
L
L
D
-----
V
E
L
-
D
R
-
F
-
R
----
S
A
-
N
-----------
P
-
E
----
A
---
D
L
--
S
V
------
L
---
K
Q
A
A
-----
E
V
Q
Y
S
Q
SG
F
A
Y
I
NSFQE
L
F
E
-
A
-
D
E
P
------
I
D
F
Y
--
N
I
L
G
F
S
FF
K
E
K
L
E
A
G
W
K
R
YEHA
E
D
L
T
L
V
S
S
A
E
H
N
---
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
--
A
--
V
T
L
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----
10
PsiBlast_PDB
77.30
29%
-77
- C1 -
2RAV
2
?
A:
[1-258]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
-
I
I
N
N
L
S
E
--
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
---------------------------
F
--
V
G
----
E
E
V
I
Y
K
-
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
-
V
P
C
I
-
F
V
E
E
H
N
I
S
V
---------------------
C
Q
P
N
-
E
-
M
----
V
K
-
K
-----------
I
-
F
----
Y
DFL
H
V
--
N
V
I
P
T
V
S
F
E
---
E
A
S
N
-----
K
-
E
V
I
Q
-----------
M
T
P
-
F
-
I
T
E
------
E
E
E
K
--
E
V
L
------
P
S
I
P
T
C
E
I
-----
G
R
W
Y
-----
P
A
F
---
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
7
PsiBlast_PDB
76.64
30%
-79
- C1 -
2RB5
2
?
A:
[1-258]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
-
I
I
N
N
L
S
E
--
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
---------------------------
F
--
V
G
----
E
E
V
I
Y
K
-
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
-
V
P
C
I
-
F
V
E
E
H
N
I
S
V
---------------------
C
Q
P
N
-
E
-
M
----
V
K
-
K
-----------
I
-
F
----
Y
DFL
H
V
--
N
V
I
P
T
V
S
F
E
---
E
A
S
N
-----
K
-
E
V
I
Q
-----------
M
T
P
-
F
-
I
T
E
------
E
E
E
K
--
E
V
L
------
P
S
I
P
T
C
E
I
-----
G
R
W
Y
-----
P
A
F
---
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
8
PsiBlast_PDB
76.33
30%
-78
- C1 -
2RBK
2
?
A:
[1-258]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
-
I
I
N
N
L
S
E
--
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
---------------------------
F
--
V
G
----
E
E
V
I
Y
K
-
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
-
V
P
C
I
-
F
V
E
E
H
N
I
S
V
---------------------
C
Q
P
N
-
E
-
M
----
V
K
-
K
-----------
I
-
F
----
Y
DFL
H
V
--
N
V
I
P
T
V
S
F
E
---
E
A
S
N
-----
K
-
E
V
I
Q
-----------
M
T
P
-
F
-
I
T
E
------
E
E
E
K
--
E
V
L
------
P
S
I
P
T
C
E
I
-----
G
R
W
Y
-----
P
A
F
---
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
9
PsiBlast_PDB
76.23
29%
-79
- C1 -
2RAR
2
?
A:
[1-258]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
-
I
I
N
N
L
S
E
--
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
---------------------------
F
--
V
G
----
E
E
V
I
Y
K
-
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
-
V
P
C
I
-
F
V
E
E
H
N
I
S
V
---------------------
C
Q
P
N
-
E
-
M
----
V
K
-
K
-----------
I
-
F
----
Y
DFL
H
V
--
N
V
I
P
T
V
S
F
E
---
E
A
S
N
-----
K
-
E
V
I
Q
-----------
M
T
P
-
F
-
I
T
E
------
E
E
E
K
--
E
V
L
------
P
S
I
P
T
C
E
I
-----
G
R
W
Y
-----
P
A
F
---
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
6
PsiBlast_PDB
76.13
30%
-80
- C1 -
1YMQ
3
?
A:
[2-258]
-
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
-
I
I
N
N
L
S
E
--
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
---------------------------
F
--
V
G
----
E
E
V
I
Y
K
-
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
-
V
P
C
I
-
F
V
E
E
H
N
I
S
V
---------------------
C
Q
P
N
-
E
-
M
----
V
K
-
K
-----------
I
-
F
----
Y
DFL
H
V
--
N
V
I
P
T
V
S
F
E
---
E
A
S
N
-----
K
-
E
V
I
Q
-----------
M
T
P
-
F
-
I
T
E
------
E
E
E
K
--
E
V
L
------
P
S
I
P
T
C
E
I
-----
G
R
W
Y
-----
P
A
F
---
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
75
Fugue
75.76
29%
-90
- C1 -
1NF2
3
?
A:
[1-267]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
-
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
-
R
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
K
K
--
Y
--
F
K
R
T
F
P
T
I
A
Y
N
G
A
I
V
---------------------------
Y
L
P
E
E
----
G
V
I
L
N
E
--
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
L
N
-
V
H
W
Q
-
A
Y
I
D
D
V
L
Y
S
-----
E
K
--
D
N
-
E
E
-----
I
K
S
Y
A
R
-
H
-
S
----
N
V
-
D
-----------
Y
-
R
----
V
---
E
P
--
N
L
------
S
---
E
L
V
S
-----
K
M
G
T
T
K
-----------
L
L
L
-
I
-
D
T
P
------
E
R
L
D
--
E
L
K
------
E
I
L
S
E
R
F
K
-----
D
V
V
K
V
F
K
S
F
P
T
Y
---
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
D
C
LD
13
PsiBlast_PDB
75.41
24%
-102
- C1 -
2QYH
5
?
A:
[4-257]
--
K
I
V
F
F
D
I
D
G
T
L
L
D
-
E
Q
-
K
Q
L
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
K
Q
--
L
G
I
----
D
S
F
V
S
F
N
G
Q
Y
V
---------------------------
V
F
E
G
N
------
V
L
Y
K
-
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
H
K
N
G
-
H
P
L
V
-
F
M
D
A
E
K
M
R
A
SIGDH
P
H
--
I
H
V
S
M
-----
A
S
L
K
F
A
-
H
-
P
----
P
V
-
D
-----------
P
-
L
----
Y
---
Y
------------------
E
-----
N
K
D
I
Y
Q
-----------
A
L
L
-
F
-
C
R
A
------
E
E
E
E
--
P
Y
V
------
R
N
Y
P
E
----------
F
R
F
V
R
W
H
D
V
S
---
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
--
F
--
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
I
---
15
PsiBlast_PDB
74.56
26%
-88
- C1 -
3PGV
9
?
A:
[21-284]
-
Y
Q
V
V
A
S
D
L
D
G
T
L
L
S
-
P
D
-
H
F
L
T
P
Y
A
K
E
T
L
K
L
L
T
A
R
G
I
N
F
V
F
A
T
G
R
H
Y
I
D
V
G
Q
I
R
D
N
--
L
G
I
R
---
S
Y
M
I
T
S
N
G
A
R
V
---------------------------
H
D
S
D
G
----
Q
Q
I
F
A
H
--
N
L
D
R
D
I
A
A
D
L
F
E
I
V
R
N
D
P
-
K
I
V
T
N
V
Y
R
E
D
E
W
Y
M
-----
N
R
--
H
R
----------
F
F
K
E
-
A
-
V
----
F
N
-
Y
-----------
K
-
L
----
Y
---
E
---
P
G
------
E
---
L
D
P
Q
-----
G
I
--
S
K
-----------
V
F
F
T
C
-
E
D
H
------
E
H
L
L
--
P
L
E
------
Q
A
M
N
A
R
W
G
-----
D
R
V
N
V
S
F
S
T
L
T
C
---
L
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
E
L
E
--
V
I
G
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
L
----
92
HHSearch
74.50
27%
-100
- C1 -
1NF2
3
?
A:
[1-263]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
-
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
-
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
K
K
Y
-
F
K
R
---
T
F
P
T
I
A
Y
N
G
A
I
V
---------------------------
Y
L
P
-
E
----
E
G
V
I
L
N
-
E
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
L
N
-
V
H
W
Q
-
A
Y
I
D
D
V
L
Y
S
-----
E
K
--
D
N
E
E
I
------
K
S
Y
A
R
H
S
-
N
----
V
D
-
Y
-----------
R
-
V
E
P--
N
---
L
S
--
E
L
------
V
----
S
K
-------
M
G
T
T
K
-----------
L
L
L
-
I
D
T
P
E
-------
R
L
D
--
E
L
K
------
E
I
L
S
E
R
F
K
-----
D
V
V
K
V
F
K
S
F
P
T
Y
---
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
----
89
HHSearch
73.74
25%
-94
- C1 -
3PGV
9
?
A:
[21-284]
-
Y
Q
V
V
A
S
D
L
D
G
T
L
L
S
-
P
D
-
H
F
L
T
P
Y
A
K
E
T
L
K
L
L
T
A
R
G
I
N
F
V
F
A
T
G
R
H
Y
I
D
V
G
Q
I
R
D
N
--
L
G
I
---
R
S
Y
M
I
T
S
N
G
A
R
V
---------------------------
H
D
S
-
D
----
G
Q
Q
I
F
A
-
H
N
L
D
R
D
I
A
A
D
L
F
E
I
V
R
N
D
P
K
I
V
T
N
-
V
Y
R
E
D
E
W
Y
M
-----
N
R
--
H
R
----------
F
F
K
E
-
A
-
V
----
F
N
-
Y
-----------
K
L
Y
----
E
---
P
G
--
E
L
------
D
-----
P
-------
Q
G
I
S
K
-----------
V
F
F
-
T
C
E
D
H
------
E
H
L
L
--
P
L
E
------
Q
A
M
N
A
R
W
G
-----
D
R
V
N
V
S
F
S
T
L
T
C
---
L
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
--
E
L
E
V
I
G
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
L
----
94
HHSearch
73.59
29%
-78
- C1 -
2RBK
2
?
A:
[1-260]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
-
F
E
T
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
L
Q
D
R
N
L
---
I
D
G
Y
I
T
M
N
G
A
Y
C
---------------------------
F
V
G
------
E
E
V
I
Y
K
-
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
-
V
P
C
I
-
F
V
E
E
H
N
I
S
V
-----
C
Q
--
P
N
E
M
V
-----
K
K
I
F
Y
D
-
F
-
L
-----
H
-
V
-----------
N
-
V
I
---
P
---
T
V
--
S
F
------
E
---
E
A
S
N
------
K
E
V
I
Q
-----------
M
T
P
-
F
I
T
E
E
-------
E
E
------------
K
E
V
L
P
S
I
P
------
T
C
E
I
G
R
W
Y
P
A
F
---
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
----
96
HHSearch
73.00
25%
-94
- C1 -
3R4C
4
?
A:
[11-266]
M
I
K
V
L
L
L
D
V
D
G
T
L
L
S
-
F
E
T
H
K
V
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
A
A
S
D
L
H
E
I
D
-
A
--
V
P
----
Y
D
G
V
I
A
L
N
G
A
E
C
---------------------------
V
L
R
-
D
----
G
S
V
I
R
K
-
V
A
I
P
A
Q
D
F
R
K
S
M
E
L
A
R
E
F
D
-
F
A
V
A
-
L
E
L
N
E
G
V
F
V
-----
N
R
--
L
T
P
T
------
V
E
Q
I
A
G
-
I
V
E
----
H
P
-
V
-----------
P
-
P
--------
V
V
--
D
I
------
E
---
E
M
F
E
-----
R
K
E
C
C
Q
-----------
L
C
F
-
Y
F
D
E
E
-------
A
E
------------
Q
K
V
M
P
L
L
S
------
G
L
S
A
T
R
W
H
P
L
F
---
A
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
--
F
--
V
T
D
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
G
-----
5
PsiBlast_PDB
72.31
27%
-95
- C1 -
1NF2
3
?
A:
[1-264]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
-
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
K
C
Y
-
V
V
F
A
S
G
R
M
L
V
S
T
L
N
--
V
E
--
K
K
Y
F
K
R
T
F
P
T
I
A
Y
N
G
A
I
V
Y
L
PEEGVI
L
N
E
K
IPP
E
V
A
K
D
I
I
E
Y
I
K
P
L
N
V
H
W
----
Q
A
Y
I
D
D
-
V
L
Y
S
E
K
D
N
E
E
I
K
S
Y
A
R
H
S
N
-
V
D
----------
Y
R
-----
V
E
--
P
N
L
S
E
-----
L
V
S
K
----------
M
G
-
T
---------------------------------------------------
T
K
-----------
L
L
L
-
I
-
D
T
P
------
E
R
L
D
--
E
L
K
------
E
I
L
S
E
R
F
K
-----
D
V
V
K
V
F
K
S
F
P
T
Y
---
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
D
---
11
PsiBlast_PDB
68.29
31%
-54
- C1 -
3DNP
1
YHAX_BACSU
A:
[7-267]
--
Q
L
L
A
L
N
I
D
G
A
L
L
R
-
S
N
-
G
K
I
H
Q
A
T
K
D
A
I
E
Y
V
K
K
K
G
I
Y
V
T
L
V
T
N
R
H
F
R
S
A
Q
K
I
A
K
S
--
L
K
L
D
A
K
---
L
I
T
H
S
G
A
Y
I
---------------------------
A
E
K
I
D
APF
F
E
K
R
I
S
D
D
H
T
F
N
I
V
Q
V
L
E
S
Y
Q
-
C
N
I
R
L
-
L
H
E
K
-
Y
S
I
G
N
K
K
K
V
-----------------------
N
S
-
N
-
L
----
L
G
-
K
-----------
A
-
L
----
I
---
H
P
S
D
P
I
------
F
---
Y
P
V
Q
-----
F
V
E
S
L
S
-----------
D
L
L
-
M
-
D
E
P
VSAP
V
I
E
V
Y
T
EH
D
I
Q
------
H
D
I
T
E
T
I
T
-----
K
A
F
P
A
V
D
V
I
R
V
N
DE
K
L
N
I
V
P
K
G
V
S
K
E
A
G
L
A
L
V
A
S
E
L
G
L
S
M
D
D
V
V
A
I
G
H
Q
Y
D
D
L
P
M
I
E
L
A
G
L
G
V
A
M
G
N
A
V
P
E
I
K
R
K
A
D
--
W
--
V
T
R
S
N
D
E
Q
G
V
A
------------