@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0180: (2016-03-12 )
MKTEKSGSPKWQLFKNILTYTIICLGGIIMLMPFVWMVSTAFKTGAANMVLPPQFIPKEPTTANFTQVFEMFPMLRFLVNSVIVAVVTTLGQMLFCSMAAYAFARIPFWGRDKLFLLYLATMMVPAQVTMIPQFILMKQFGWLDSYAGLIVPALFSVFGTFLLRQAFMGIPKELEEAAFMDGANHFTIFRKVILPLAKPTFATLGILTFMQSWNSYLWPLIVTSSQEMATLPLGLSLLQGRYGTNYGLMMAGVLISVIPILAVYLFAQKYFIQGMAMSGMKE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........-70..----......80........90........100.......110.......120.......130.......-140-----.------.---------.-------------------.....--------150..-.-.-.-..160....---...170.......180.......190.......200.......210.......220..-...----------..230......--------------.240-.....--...250...----------------....260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKTEKSGS
P
K
W
Q
L
F
K
N
I
L
T
Y
T
I
I
C
L
G
G
I
I
M
L
M
P
F
V
W
M
V
S
T
A
FKTGAANMVLPPQFIPKEPTT
A
N
F
T
Q
V
F
-
E
M
F
P
----
M
L
R
F
L
V
N
S
V
I
V
A
V
V
T
T
L
G
Q
M
L
F
C
S
M
A
A
Y
A
F
ARIPFWGR
D
K
L
F
L
L
Y
L
A
T
M
MVP
A
Q
V
T
M
I
P
Q
F
I
L
M
K
Q
-FG------
W
------
L
---------
D
-------------------
S
Y
A
G
L
--------
I
V
P
A
L
-
F
-
S
-
V
-
F
G
T
F
L
L
R
Q
A
---
F
MGI
P
K
E
L
E
E
A
A
FMDGA
N
H
F
T
I
F
R
K
V
I
LPLAK
P
T
F
A
T
L
G
I
L
T
F
M
Q
S
W
NS
Y
L
W
P
L
I
VTS-SQE----------MAT
L
P
L
G
L
S
L
L
--------------QGR--YGT
N
Y
--
G
L
M
M
A
G
V
L
I
----------------
S
V
I
P
I
L
A
V
Y
L
F
A
Q
K
Y
F
I
Q
G
M
A
MSGMKE
32
Fugue
88.65
26%
-125
- C4 -
4TQU
-
?
N:
[2-284]
--
L
A
T
P
F
Y
S
R
S
D
R
I
F
G
I
V
N
A
V
L
L
G
I
F
A
L
C
A
L
Y
P
I
I
Y
I
F
S
M
S
I
S
S
G
A
A
V
T
Q
G
R
V
F
L
L
P
V
D
I
D
F
S
A
Y
G
R
V
L
-
H
D
K
L
----
F
W
T
S
Y
A
N
T
I
F
Y
T
V
F
G
V
V
T
S
L
I
F
I
V
P
G
A
Y
A
L
S
K
P
R
I
R
G
R
R
V
F
G
F
I
I
A
F
T
M
W
F
N
A
G
--
M
I
P
F
F
L
N
M
R
D
-
L
G
------
L
------
L
---------
D
-------------------
N
R
F
G
I
--------
L
I
G
F
A
-
C
-
N
-
A
-
F
N
I
I
L
M
R
N
Y
---
F
E
S
I
S
A
S
F
E
E
A
A
R
M
D
G
A
N
D
L
Q
I
L
W
K
V
Y
I
P
L
A
K
P
A
L
A
T
I
T
L
L
C
A
I
S
R
W
N
G
Y
F
W
A
M
V
L
L
R
-
A
E
E
----------
K
I
P
L
Q
V
Y
L
K
K
T
IVDLNVNEEFAGAL
L
T
N
--
S
Y
S
M
E
--
T
V
V
G
A
I
I
V
M
----------------
S
I
I
P
V
I
I
V
Y
P
V
V
Q
K
Y
F
T
K
---------
1
PsiBlast_PDB
86.51
29%
-121
- C4 -
4TQU
-
?
N:
[30-284]
------------------------------
L
Y
P
I
I
Y
I
F
S
M
S
I
S
S
G
A
A
V
T
Q
G
R
V
F
L
L
P
V
D
I
D
F
S
A
Y
G
R
V
L
-
H
D
K
L
----
F
W
T
S
Y
A
N
T
I
F
Y
T
V
F
G
V
V
T
S
L
I
F
I
V
P
G
A
Y
A
L
S
K
P
R
I
R
G
R
R
V
F
G
F
I
I
A
F
T
M
W
F
N
A
G
--
M
I
P
F
F
L
N
M
R
D
-
L
G
------
L
------
L
---------
D
-------------------
N
R
F
G
I
--------
L
I
G
F
A
-
C
-
N
-
A
-
F
N
I
I
L
M
R
N
Y
---
F
E
S
I
S
A
S
F
E
E
A
A
R
M
D
G
A
N
D
L
Q
I
L
W
K
V
Y
I
P
L
A
K
P
A
L
A
T
I
T
L
L
C
A
I
S
R
W
N
G
Y
F
W
A
M
V
L
L
R
-
A
E
E
------------
K
I
P
L
Q
V
Y
L
K
--------------
K
T
I
--
V
D
L
N
V
--
N
E
E
F
A
G
A
L
L
TNSYSMETVVGAIIVM
S
I
I
P
V
I
I
V
Y
P
V
V
Q
K
Y
F
T
K
---------
2
PsiBlast_PDB
85.68
29%
-123
- C4 -
4TQV
-
?
B:
[30-287]
------------------------------
L
Y
P
I
I
Y
I
F
S
M
S
I
S
S
G
A
A
V
T
Q
G
R
V
F
L
L
P
V
D
I
D
F
S
A
Y
G
R
V
L
-
H
D
K
L
----
F
W
T
S
Y
A
N
T
I
F
Y
T
V
F
G
V
V
T
S
L
I
F
I
V
P
G
A
Y
A
L
S
K
P
R
I
R
G
R
R
V
F
G
F
I
I
A
F
T
M
W
F
N
A
G
--
M
I
P
F
F
L
N
M
R
D
-
L
G
------
L
------
L
---------
D
-------------------
N
R
F
G
I
--------
L
I
G
F
A
-
C
-
N
-
A
-
F
N
I
I
L
M
R
N
Y
---
F
E
S
I
S
A
S
F
E
E
A
A
R
M
D
G
A
N
D
L
Q
I
L
W
K
V
Y
I
P
L
A
K
P
A
L
A
T
I
T
L
L
C
A
I
S
R
W
N
G
Y
F
W
A
M
V
L
L
R
-
A
E
E
------------
K
I
P
L
Q
V
Y
L
K
--------------
K
T
I
--
V
D
L
N
V
--
N
E
E
F
A
G
A
L
L
T
N
SYS
M
E
T
V
V
G
A
I
I
V
M
S
I
I
P
V
I
I
V
Y
P
V
V
Q
K
Y
F
T
K
G
V
M
------
8
PsiBlast_PDB
85.40
30%
-142
- C4 -
3PUV
4
MALG_ECOLI
G:
[79-295]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
-
11
PsiBlast_PDB
85.27
30%
-142
- C4 -
3RLF
2
MALG_ECOLI
G:
[79-295]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
-
14
PsiBlast_PDB
84.73
30%
-139
- C4 -
4KI0
8
?
G:
[79-295]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
-
9
PsiBlast_PDB
84.64
30%
-139
- C4 -
3PUW
5
MALG_ECOLI
G:
[79-295]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
-
10
PsiBlast_PDB
84.35
30%
-141
- C4 -
3PUX
3
MALG_ECOLI
G:
[79-295]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
-
3
PsiBlast_PDB
83.74
30%
-138
- C4 -
2R6G
-
MALG_ECOLI
G:
[79-295]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
-
5
PsiBlast_PDB
83.21
30%
-139
- C4 -
3PUY
-
MALG_ECOLI
G:
[79-295]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
-
31
Fugue
82.46
27%
-148
- C4 -
3FH6
-
MALG_ECOLI
G:
[3-287]
-----
M
V
Q
P
K
S
Q
K
A
R
L
F
I
T
H
L
L
L
L
L
F
I
A
A
I
M
F
P
L
L
M
V
V
A
I
S
L
R
Q
---------------------
R
I
T
P
-
P
P
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
------
E
YIPFIG
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
I
A
-
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
L
L
R
-
D
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
--------------
L
N
P
--
Q
N
Y
L
W
--
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
---------
13
PsiBlast_PDB
80.70
30%
-138
- C4 -
4KHZ
1
?
G:
[79-283]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
-------------
7
PsiBlast_PDB
80.40
30%
-135
- C4 -
3PV0
1
MALG_ECOLI
G:
[79-283]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
-------------
6
PsiBlast_PDB
80.01
30%
-132
- C4 -
3PUZ
1
MALG_ECOLI
G:
[79-283]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
-------------
12
PsiBlast_PDB
79.84
30%
-133
- C4 -
4JBW
-
MALG_ECOLI
G:
[79-287]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
---------
4
PsiBlast_PDB
75.60
30%
-142
- C4 -
3FH6
-
MALG_ECOLI
G:
[79-287]
------------------------------------------------------------------------
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
V
L
S
L
V
A
L
Y
A
L
F
D
R
-
L
G
EYIPFI
G
------
L
---------
N
-------------------
T
H
G
G
V
--------
I
F
A
Y
L
-
G
-
G
-
I
A
L
H
V
W
T
I
K
G
Y
---
F
E
T
I
D
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
F
I
A
A
I
T
E
V
--
P
V
A
S
L
L
-
L
R
D
----------
V
N
S
Y
T
L
A
V
G
M
Q
--------------
Q
Y
L
--
N
P
Q
N
Y
LW
G
D
F
A
A
A
A
V
M
----------------
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
---------
23
HHSearch
74.49
23%
-136
* C4 *
3RLF
2
MALF_ECOLI
F:
[258-503]
----------------------------------------------------------
T
T
G
W
K
N
F
T
R
V
F
T
D
E
-
G
IQKP
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
L
V
Q
W
E
A
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
------
E
------
I
---------
N
MMLSALFGVKPAWFSDPTT
A
R
T
M
L
--------
I
I
V
N
T
-
W
L
G
Y
P
-
Y
M
M
I
L
C
M
G
L
---
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
P
D
RLGTTTPAGY
T
D
L
L
V
N
Y
T
Y
R
I
--------------
A
F
E
GG
G
G
Q
D
F
--
G
L
A
A
A
I
A
T
L
----------------
I
F
L
L
V
G
A
L
A
I
-----------------
21
HHSearch
73.48
18%
-140
- C4 -
2ONK
-
WTPB_ARCFU
C:
[27-272]
-------------
L
F
S
A
L
L
A
L
L
S
S
I
I
L
L
F
V
L
L
P
V
A
A
T
V
T
L
Q
L
F
N
-----------------
F
D
E
F
L
K
A
A
S
D
P
-
A
----
V
W
K
V
V
L
T
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
I
L
A
R
K
S
F
P
G
K
S
V
V
E
G
I
V
D
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
F
G
S
-
S
G
------
L
------
I
GSFSPLKFV
D
-------------------
A
L
P
G
I
--------
V
V
A
M
L
F
V
-
S
V
P
-
I
Y
I
N
Q
A
K
E
G
---
F
A
S
V
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
E
F
G
A
V
V
V
I
A
Y
---
Y
----------
P
M
I
A
P
T
L
I
Y
E
R
--------------
Y
L
S
----
E
G
L
--
S
A
A
M
P
V
A
A
I
----------------
L
I
L
L
S
L
A
V
F
V
A
L
R
I
-------------
22
HHSearch
72.38
17%
-140
- C4 -
3D31
-
?
C:
[47-283]
------------------------
V
L
F
L
F
I
F
L
T
L
S
N
M
I
F
E
Q
I
T
E
----------------
D
F
S
G
L
V
K
A
A
G
N
R
-
S
----
V
I
S
S
I
F
L
S
L
Y
A
G
F
L
A
T
L
L
A
L
L
L
G
A
P
T
G
Y
I
L
A
R
F
D
F
P
G
K
R
L
V
E
S
I
I
D
V
P
V
V
V
P
H
T
V
A
G
I
A
L
L
T
V
F
G
S
-
R
G
------
L
------
I
---------
G
EPLESYIQFRD--------
A
L
P
G
I
--------
V
V
A
M
L
F
V
-
S
M
P
-
Y
L
A
N
S
A
R
E
G
---
F
K
S
V
D
P
R
L
E
N
A
A
R
S
L
G
A
P
L
W
K
A
F
F
F
V
T
L
P
L
S
A
R
Y
L
L
I
G
S
V
M
T
W
A
R
A
I
S
E
F
G
A
V
V
I
L
A
Y
---
Y
----------
P
M
V
G
P
T
L
I
Y
D
R
--------------
F
I
S
----
Y
G
L
--
S
A
S
R
P
I
A
V
L
----------------
L
I
L
V
T
L
S
I
F
L
V
-
I
R
-------------
33
Fugue
70.80
17%
-136
- C4 -
2ONK
-
WTPB_ARCFU
C:
[24-275]
---------------------------
M
R
L
L
F
S
A
L
L
A
L
L
S
S
I
I
L
L
F
V
L
L
P
V
A
A
T
V
T
L
Q
L
F
N
F
D
E
F
L
K
A
A
-
S
D
P
A
----
V
W
K
V
V
L
T
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
I
L
A
R
K
S
F
P
G
K
S
V
V
E
G
I
V
D
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
F
G
S
-
S
G
------
L
------
I
---------
G
-------------------
S
F
S
P
L
KFVDALPG
I
V
V
A
M
-
L
-
F
-
V
-
S
V
P
I
Y
I
N
Q
A
KEG
F
A
S
V
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
E
F
G
A
V
V
V
I
A
Y
-
Y
P
M
----------
I
------
A
P
T
L
--------------
I
Y
E
--
R
Y
L
S
E
--
G
L
S
A
A
M
P
V
A
----------------
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
--------