@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0181: (2016-03-12 )
MKKGLLLLMVVVLSVFGLSACGGGSSSGDKTEITYYQFSAPADGKALDEMVKEFEKQNPDIKVNVQTIAFNDYFTKLQTQIAGGDAPDAFELNYETFMQYAEKGVLADLTSYIEKDKDFDPSTLNKQAYDAFKYDGKQYGMVESFSNVVTIYNKDLFDKAGVEYPTADWTWKDEEAAAKKLTDAKNKVWGTSQPVTMNEFYKVAAQNGGSIFNEDLTETTINSPENVEALTHLTNEVTDSKVAPSPADLSGQLPEDLFMNGQIAMLHTGIWLFDMFQDAPFKWDVQVEAGNTQKATHFFANGIGVSKDSDKKEAAFKFASFMSANEEAAKIRIDNNWELPATENKEILQPYLDATPPDNREAVFESLQYMVLPPVVKDWNKISDYTNSEFEKVLNGDSTPEKALKNSEDNINKTMGFK
Atome Classification :
(20 SA)
.........10........20........30........40-......-..50........60........70--.......--.80..-.-.--.-...90.........100.......--110.......120.......130.-.......140.......150.......160.......170.......180..-..---.--------..-190.----...-.---.--.-----200-.........210-..-.-----..-----...220.......230.......240-----..--.....-250........260.......--270..------....---.-----280...-.--..-----.290-.-.----.....300---..----------.....310.......320...----.-....330.--------......340.......350......-------.360-........370.......------380.......390....--...400.......410......---------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKK
G
L
L
L
L
M
V
V
V
L
S
V
FGLSACGGGSSSGDK
T
E
I
T
Y
Y
Q
FSAP-AD
G
K
A
L
-
D
E
M
V
K
E
F
E
KQNP
D
I
K
V
N
V
Q
T
I
A
F
N
--
D
Y
F
T
K
L
Q
--
T
Q
IAG-G-D--A-PD
A
F
-EL
N
Y
E
T
F
M
Q
Y
A
EK
G
V
L
A
D
L
--
T
S
Y
I
E
KDKDFDPSTL
N
K
Q
A
Y
D
-
A
F-KYDGKQYG
M
V
E
S
F
S
N
V
V
T
I
YNK
D
L
F
D
KAGVEYPTADWTWK
D
E
E
A
A
A
K
K
L
TDA-KN---K--------VW-GTSQ----PV
T
-
M
---
N
--
E
-----
F
---
Y
K
V
A
A
QNGGSI--FN-E-----D
L
-----
T
E
TTINSP
E
N
V
E
A
L
T
H
L
T
N
EVTDSKV-----AP--SPADL-SG-QL
P
E
D
L
FMNG
Q
I
A
M
L
HT
G
--
I
W
L
F
D
------
M
FQD---A-----P
F
K
W
D
V
-
Q
--
V
E-----AGNT-Q-
K
----
A
T
H
F
FANG---IG----------VSKDSD
K
K
E
A
A
F
K
F
A
S
F
-MSA----N-E
E
A
A
K
I
R
I--------DNNWELPATE
N
K
E
I
L
Q
P
Y
LDATPPD-------
N
R
E
--
A
V
F
E
S
L
Q
Y
MVL
P
P
V
V
K
D
W
------
N
K
I
SDY
T
N
S
E
F
E
K
V
LNG--DS
T
P
E
K
A
LKNSEDNINKTMGFK---------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.66
25%
-41
- C1 -
4QSC
1
?
A:
[25-402]
-------------------------------
D
V
T
L
T
L
W
S
L
D
-
R
D
I
Q
P
A
-
P
N
L
I
K
E
F
N
A
L
N
N
G
I
K
I
E
Y
R
Q
L
Q
F
D
--
D
V
V
S
E
S
M
--
R
A
Y
S
T
-
G
-
N
--
A
-
P
D
I
I
-
A
I
D
N
P
N
H
A
M
F
A
S
R
G
A
F
L
D
V
--
T
D
M
I
A
K
S
D
V
I
K
T
E
N
Y
F
P
G
P
L
K
-
S
V
-
T
W
D
G
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
D
A
A
K
P
P
Q
T
W
D
E
L
V
D
A
A
R
K
L
T
N
P
-
A
K
---
N
--------
V
Y
-
G
I
S
F
----
S
A
K
-
A
---
N
--
E
E
G
T
F
Q
F
---
L
P
W
A
Q
M
A
G
A
T
Y
--
K
N
------------------
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
L
D
E
K
L
A
-----
S
P
--
D
T
L
T
R
-
S
Q
-
W
D
S
T
A
T
F
N
A
G
N
A
A
M
A
I
S
G
--
P
W
E
I
D
R
-----
M
L
K
D
---
A
-----
K
F
D
W
G
V
-
T
--
L
L
-----
P
V
P
T
-
P
-
D
----
A
P
R
S
S
A
M
G
D
Y
N
W
A
----------
I
F
S
K
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
----
K
-
D
---
K
D
M
F
--------
K
N
F
G
Q
L
P
A
R
S
D
I
P
V
-
P
P
T
G
N
A
L
K
D
E
-------
A
L
K
--
T
F
V
E
Q
L
K
Y
A
Q
P
R
G
P
S
P
E
W
------
P
K
I
S
K
A
I
Q
D
A
I
Q
G
A
L
S
G
--
Q
M
T
P
K
A
A
L
D
Q
A
A
E
K
I
----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.22
24%
-34
- C1 -
1EU8
9
MALE_THELN
A:
[2-398]
----------------------------
E
E
G
K
I
V
F
A
V
G
G
A
P
-
N
E
I
E
Y
W
-
K
G
V
I
A
E
F
E
K
K
Y
P
G
V
T
V
E
L
K
R
Q
A
T
D
--
T
E
Q
R
R
L
D
L
V
N
A
L
R
G
-
K
-
S
--
S
D
P
D
V
F
-
L
M
D
V
A
W
L
G
Q
F
I
A
S
G
W
L
E
P
L
--
D
D
Y
V
Q
K
D
-
N
Y
D
L
S
V
F
F
Q
S
V
I
N
L
A
D
-
K
Q
G
G
K
L
Y
A
L
P
V
Y
I
D
A
G
L
L
Y
Y
R
K
D
L
L
E
K
Y
G
Y
S
K
P
P
E
--
T
W
Q
E
L
V
E
M
A
Q
K
I
Q
S
G
-
E
R
---
E
TNPNFWG
F
V
W
Q
G
K
Q
Y
----
E
G
L
-
V
---
C
--
D
-----
F
---
V
E
Y
V
Y
S
N
G
G
S
L
G
E
F
K
-
D
-----
G
K
-----
W
V
P
T
L
N
K
P
E
N
V
E
A
L
Q
F
M
V
D
L
I
H
K
Y
K
I
-----
S
P
PN
T
Y
T
E
M
-
T
E
-
E
P
V
R
L
M
F
Q
Q
G
N
A
A
F
E
R
N
W
P
Y
A
W
G
L
H
------
N
A
D
D
---
S
-----
P
V
K
G
K
V
-
G
--
V
A
P
L
P
H
F
P
G
H
K
-
S
-
A
----
A
T
-
L
G
G
W
H
---
I
G
----------
I
S
K
Y
S
D
N
K
A
L
A
W
E
F
V
K
F
-
V
E
S
----
Y
-
S
V
Q
K
G
F
A
M
--------
N
L
G
W
N
P
G
R
V
D
V
Y
D
--
D
P
A
V
V
S
K
S
P
H
-------
L
K
E
L
R
A
V
F
E
N
---
A
V
P
R
P
I
V
P
Y
Y
------
P
Q
L
S
E
I
I
Q
K
Y
V
N
S
A
L
A
G
--
K
I
S
P
Q
E
A
L
D
K
A
Q
-------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.88
25%
-42
- C1 -
4QSE
2
?
A:
[25-402]
-------------------------------
D
V
T
L
T
L
W
S
L
D
-
R
D
I
Q
P
A
-
P
N
L
I
K
E
F
N
A
L
N
N
G
I
K
I
E
Y
R
Q
L
Q
F
D
--
D
V
V
S
E
S
M
--
R
A
Y
S
T
-
G
-
N
--
A
-
P
D
I
I
-
A
I
D
N
P
N
H
A
M
F
A
S
R
G
A
F
L
D
V
--
T
D
M
I
A
K
S
D
V
I
K
T
E
N
Y
F
P
G
P
L
K
-
S
V
-
T
W
D
G
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
D
A
A
K
P
P
Q
T
W
D
E
L
V
D
A
A
R
K
L
T
N
P
-
A
K
---
N
--------
V
Y
-
G
I
S
F
----
S
A
K
-
A
---
N
--
E
E
G
T
F
Q
F
---
L
P
W
A
Q
M
A
G
A
T
Y
--
K
N
------------------
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
L
D
E
K
L
A
-----
S
P
--
D
T
L
T
R
-
S
Q
-
W
D
S
T
A
T
F
N
A
G
N
A
A
M
A
I
S
G
--
P
W
E
I
D
R
-----
M
L
K
D
---
A
-----
K
F
D
W
G
V
-
T
--
L
L
-----
P
V
P
T
-
P
-
D
----
A
P
R
S
S
A
M
G
D
Y
N
W
A
----------
I
F
S
K
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
----
K
-
D
---
K
D
M
F
--------
K
N
F
G
Q
L
P
A
R
S
D
I
P
V
-
P
P
T
G
N
A
L
K
D
E
-------
A
L
K
--
T
F
V
E
Q
L
K
Y
A
Q
P
R
G
P
S
P
E
W
------
P
K
I
S
K
A
I
Q
D
A
I
Q
G
A
L
S
G
--
Q
M
T
P
K
A
A
L
D
Q
A
A
E
K
I
----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.87
25%
-42
- C1 -
4QRZ
1
?
A:
[25-402]
-------------------------------
D
V
T
L
T
L
W
S
L
D
-
R
D
I
Q
P
A
-
P
N
L
I
K
E
F
N
A
L
N
N
G
I
K
I
E
Y
R
Q
L
Q
F
D
--
D
V
V
S
E
S
M
--
R
A
Y
S
T
-
G
-
N
--
A
-
P
D
I
I
-
A
I
D
N
P
N
H
A
M
F
A
S
R
G
A
F
L
D
V
--
T
D
M
I
A
K
S
D
V
I
K
T
E
N
Y
F
P
G
P
L
K
-
S
V
-
T
W
D
G
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
D
A
A
K
P
P
Q
T
W
D
E
L
V
D
A
A
R
K
L
T
N
P
-
A
K
---
N
--------
V
Y
-
G
I
S
F
----
S
A
K
-
A
---
N
--
E
E
G
T
F
Q
F
---
L
P
W
A
Q
M
A
G
A
T
Y
--
K
N
------------------
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
L
D
E
K
L
A
-----
S
P
--
D
T
L
T
R
-
S
Q
-
W
D
S
T
A
T
F
N
A
G
N
A
A
M
A
I
S
G
--
P
W
E
I
D
R
-----
M
L
K
D
---
A
-----
K
F
D
W
G
V
-
T
--
L
L
-----
P
V
P
T
-
P
-
D
----
A
P
R
S
S
A
M
G
D
Y
N
W
A
----------
I
F
S
K
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
----
K
-
D
---
K
D
M
F
--------
K
N
F
G
Q
L
P
A
R
S
D
I
P
V
-
P
P
T
G
N
A
L
K
D
E
-------
A
L
K
--
T
F
V
E
Q
L
K
Y
A
Q
P
R
G
P
S
P
E
W
------
P
K
I
S
K
A
I
Q
D
A
I
Q
G
A
L
S
G
--
Q
M
T
P
K
A
A
L
D
Q
A
A
E
K
I
----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.58
25%
-39
- C1 -
4QSD
2
?
A:
[25-402]
-------------------------------
D
V
T
L
T
L
W
S
L
D
-
R
D
I
Q
P
A
-
P
N
L
I
K
E
F
N
A
L
N
N
G
I
K
I
E
Y
R
Q
L
Q
F
D
--
D
V
V
S
E
S
M
--
R
A
Y
S
T
-
G
-
N
--
A
-
P
D
I
I
-
A
I
D
N
P
N
H
A
M
F
A
S
R
G
A
F
L
D
V
--
T
D
M
I
A
K
S
D
V
I
K
T
E
N
Y
F
P
G
P
L
K
-
S
V
-
T
W
D
G
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
D
A
A
K
P
P
Q
T
W
D
E
L
V
D
A
A
R
K
L
T
N
P
-
A
K
---
N
--------
V
Y
-
G
I
S
F
----
S
A
K
-
A
---
N
--
E
E
G
T
F
Q
F
---
L
P
W
A
Q
M
A
G
A
T
Y
--
K
N
------------------
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
L
D
E
K
L
A
-----
S
P
--
D
T
L
T
R
-
S
Q
-
W
D
S
T
A
T
F
N
A
G
N
A
A
M
A
I
S
G
--
P
W
E
I
D
R
-----
M
L
K
D
---
A
-----
K
F
D
W
G
V
-
T
--
L
L
-----
P
V
P
T
-
P
-
D
----
A
P
R
S
S
A
M
G
D
Y
N
W
A
----------
I
F
S
K
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
----
K
-
D
---
K
D
M
F
--------
K
N
F
G
Q
L
P
A
R
S
D
I
P
V
-
P
P
T
G
N
A
L
K
D
E
-------
A
L
K
--
T
F
V
E
Q
L
K
Y
A
Q
P
R
G
P
S
P
E
W
------
P
K
I
S
K
A
I
Q
D
A
I
Q
G
A
L
S
G
--
Q
M
T
P
K
A
A
L
D
Q
A
A
E
K
I
----------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.20
22%
-52
- C1 -
3UOR
-
?
A:
[27-411]
-----------------------------
K
T
T
V
R
F
W
A
M
G
K
E
-
A
E
--
V
V
-
A
E
L
V
A
D
F
E
K
Q
N
P
T
I
H
V
D
V
Q
N
I
P
M
T
--
A
A
H
E
K
L
L
--
T
A
F
A
A
-
D
-
G
--
L
-
P
D
V
C
-
Q
L
G
N
T
W
L
P
E
F
A
L
L
D
T
L
E
P
M
--
Q
P
Y
V
A
R
S
K
I
V
D
P
A
D
Y
F
P
G
V
W
D
-
T
N
-
L
V
D
G
T
L
Y
G
V
P
W
Y
V
D
T
R
L
L
F
Y
R
K
D
L
L
R
E
A
G
--
Y
S
Q
M
P
K
T
W
A
E
M
E
---
Q
V
M
A
A
I
-
K
R
---
K
--------
V
G
-
P
D
R
Y
----
A
I
L
-
M
P
L-
N
--
E
-----
F
E
Q
Q
L
S
F
A
L
Q
Q
D
D
R
L
--
L
R
-
D
-----
H
D
-----
N
Y
G
N
F
R
G
A
G
F
R
K
A
L
G
F
Y
D
N
-
M
Y
Q
Q
G
W
-----
A
P
--
K
V
S
E
T
-
Q
V
-
S
N
V
W
Y
E
F
F
N
G
Y
Y
A
F
Y
L
S
G
--
P
W
N
V
R
------
E
F
K
-----------
L
R
Q
P
P
-
G
--
M
E
------
G
N
W
-
G
-
T
----
A
P
L
P
G
P
N
G
---
L
G
A
G
I
A
G
G
S
S
L
V
I
F
K
S
S
Q
H
K
D
A
S
W
K
L
I
E
Y
-
L
S
Q
----
P
-
Q
V
Q
A
R
F
H
A
I
IGDLPPR
R
S
T
W
K
L
P
S
L
A
N
D
A
L
A
H
A
F
G
D
---------------------
Q
L
E
R
V
K
A
T
P
K
V
L
E
W
------
E
R
I
V
Q
E
M
R
L
V
T
E
R
V
V
R
G
--
G
Q
S
H
D
A
A
V
Q
E
L
D
Q
R
V
D
E
I
L
------------------------------------------------------------------------------------------
60
Fugue
78.84
20%
-37
- C1 -
2VGQ
6
MALE_ECOLI (first)
A:
[17-477]
I
E
E
G
K
L
V
I
W
I
----------------------------
N
G
D
-
K
G
Y
N
G
L
-
A
E
V
G
K
K
F
E
K
D
T
---
G
I
K
V
T
V
E
H
P
D
--
K
L
E
E
K
F
P
--
Q
V
A
A
T
-
G
-
D
--
G
-
P
D
I
I
-
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
A
E
I
--
T
P
D
K
A
F
Q
D
K
L
-----
Y
P
F
T
W
D
-
A
V
-
R
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
----
P
K
---
T
W
E
E
I
P
A
L
D
K
E
L
K
A
K
-
G
K
---
S
--------
A
L
-
M
F
N
L
----
Q
-
E
-
P
---
Y
--
F
-----
T
---
W
P
L
I
A
A
D
G
G
Y
A
--
F
K
-
Y
ENGKY
D
I
-----
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
K
N
K
H
M
----------
N
A
D
T
-
D
Y
-
S
I
A
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
--
P
W
A
W
S
------
N
I
D
T
---
S
-----
K
V
N
Y
G
V
-
T
V
L
P
T
-----
F
K
G
Q
-
P
-
S
----
K
P
F
V
G
V
L
S
---
A
G
----------
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
E
N
-
Y
L
L
----
T
-
D
E
G
L
E
-
A
V
--------
N
K
D
K
P
L
G
A
V
A
L
K
S
Y
E
E
E
L
---
A
K
D
P
-------
R
I
A
--
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
------
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
--
R
Q
T
V
D
E
A
L
K
D
A
Q
T
N
S
A
M
A
F
A
E
D
K
T
Y
K
Y
I
C
R
N
FSNFCNVDVVEILPYLPCLT
A
R
D
Q
D
R
L
R
A
T
C
T
L
SG
N
R
D
T
L
W
H
L
F
N
T
L
Q
R
RPG
W
V
E
Y
F
I
A
A
L
R
G
C
EL
V
D
L
A
D
E
V
A
S
V
Y
Q
35
HHSearch
77.03
22%
-30
* C1 *
1EU8
9
MALE_THELN
A:
[2-407]
----------------------------
E
E
G
K
I
V
F
A
V
G
G
A
P
-
N
E
I
E
Y
W
-
K
G
V
I
A
E
F
E
K
K
Y
P
G
V
T
V
E
L
K
R
Q
A
T
D
T
E
Q
R
R
L
D
L
V
--
N
A
L
R
G
K
S
-
S
--
D
-
P
D
V
F
-
L
M
D
V
A
W
L
G
Q
F
I
A
S
G
W
L
E
P
L
--
D
D
Y
V
Q
K
D
N
-
Y
D
L
S
V
F
F
Q
S
V
I
N
-
L
A
D
K
Q
G
G
K
L
Y
A
L
P
V
Y
I
D
A
G
L
L
Y
Y
R
K
D
L
L
E
K
Y
G
Y
S
K
P
P
--
E
T
W
Q
E
L
V
E
M
A
Q
K
I
Q
S
G
E
R
E
TNP
N
--------
F
W
-
G
F
V
W
----
Q
G
K
-
Q
Y
E
G
L
V
C
D
-----
F
---
V
E
Y
V
Y
S
N
G
G
S
L
--
G
E
F
K
-----
D
G
K
----
W
V
P
T
L
N
K
P
E
N
V
E
A
L
Q
F
M
V
D
L
I
H
K
Y
K
I
-----
S
P
--
P
N
T
Y
T
E
M
T
E
E
P
V
R
L
M
F
Q
Q
G
N
A
A
F
E
R
N
W
--
P
Y
A
W
G
------
L
H
N
A
DDS
P
V----
K
G
K
V
G
V
A
P
--
L
P
-----
H
F
P
G
H
K
-
S
----
A
A
T
L
G
G
W
H
---
I
G
----------
I
S
K
Y
S
D
N
K
A
L
A
W
E
F
V
K
F
-
V
E
S
----
Y
-
S
V
-
Q
K
G
F
A
--------
M
N
L
G
W
N
P
G
R
V
D
V
Y
D
D
P
A
V
V
S
K
S
--
P
-------
H
L
K
--
E
L
R
A
V
F
E
N
A
V
P
R
P
I
V
P
Y
Y
------
P
Q
L
S
E
I
I
Q
K
Y
V
N
S
A
L
A
G
--
K
I
S
P
Q
E
A
L
D
K
A
Q
K
E
A
E
E
L
V
K
Q
----------------------------------------------------------------------------------------
32
HHSearch
77.03
20%
-46
- C1 -
3UOR
-
?
A:
[27-413]
-----------------------------
K
T
T
V
R
F
W
A
M
G
K
---
E
A
E
V
V
-
A
E
L
V
A
D
F
E
K
Q
N
P
T
I
H
V
D
V
Q
N
I
P
M
T
--
A
A
H
E
K
L
L
--
T
A
F
A
A
-
D
-
G
--
L
-
P
D
V
C
-
Q
L
G
N
T
W
L
P
E
F
A
L
L
D
T
L
E
P
M
--
Q
P
Y
V
A
R
S
K
I
V
D
P
A
D
Y
F
P
G
V
W
D
-
T
N
-
L
V
D
G
T
L
Y
G
V
P
W
Y
V
D
T
R
L
L
F
Y
R
K
D
L
L
R
E
A
G
Y
S
Q
M
P
--
K
T
W
A
E
M
E
Q
V
M
A
A
I
K
R
K
V
G
P
---
D
--------
R
Y
-
A
I
L
M
----
P
L
N
-
E
---
F
E
-
Q
-----
Q
---
L
S
F
A
L
Q
Q
D
D
R
L
--
L
R
-
D
-----
H
D
-----
N
Y
G
N
F
R
G
A
G
F
R
K
A
L
G
F
Y
D
N
M
Y
Q
Q
G
W
A
-----
P
K
--
V
S
E
-
T
-
Q
V
-
S
N
V
W
Y
E
F
F
N
G
Y
Y
A
F
Y
L
S
G
--
P
W
N
V
R
------
E
F
K
L
---
R
QPPGM
E
G
N
W
G
T
A
P
--
L
P
-----
G
P
N
G
-
L
-
G
----
A
G
I
A
G
G
S
S
---
L
V
----------
I
F
K
S
S
Q
H
K
D
A
S
W
K
L
I
E
Y
-
L
S
Q
----
P
-
Q
V
-
Q
A
R
F
H
--------
A
I
I
G
D
L
P
P
R
R
S
T
W
K
L
P
S
L
A
N
D
A
----------
L
A
H
--
A
F
G
D
Q
L
E
R
V
K
A
T
P
K
V
L
E
W
------
E
R
I
V
Q
E
M
R
L
V
T
E
R
V
V
R
G
--
G
Q
S
H
D
A
A
V
Q
E
L
D
Q
R
V
D
E
I
L
A
K
----------------------------------------------------------------------------------------
36
HHSearch
75.78
20%
-46
- C1 -
2ZYO
1
?
A:
[16-394]
---------------------------
G
K
P
D
K
L
V
V
W
E
N
A
D
D
G
V
Q
L
N
N
T
-
K
K
W
A
G
E
F
T
K
K
-
T
G
I
Q
V
E
V
V
P
V
A
L
L
--
K
Q
Q
E
K
L
T
--
L
D
G
P
A
-
G
-
K
--
G
-
A
D
L
V
-
T
W
P
H
D
R
L
G
E
A
V
T
K
G
L
L
Q
P
I
--
Q
V
D
N
S
----
V
-
K
N
Q
F
D
D
V
A
M
K
-
A
L
-
T
Y
G
G
K
L
Y
G
L
P
K
A
I
E
S
V
A
L
I
Y
N
K
K
L
M
G
Q
----
V
P
---
A
T
Y
D
E
L
F
Q
Y
A
K
A
N
N
K
P
-
D
E
---
Q
--------
K
Y
-
G
V
L
F
----
E
A
N
-
N
---
F
Y-
Y
-----
T
---
Y
F
L
F
A
A
K
G
A
A
V
--
F
K
-
E
-----
Q
D
GTLDP
N
E
I
G
L
N
S
P
E
A
V
Q
G
M
N
E
V
Q
K
W
F
T
E
A
R
L
------
P
--
Q
S
L
K
---
A
-
D
T
V
N
G
L
F
K
S
G
K
V
A
A
V
I
N
G
--
P
W
A
I
K
------
D
Y
Q
A
---
A
-----
G
I
N
V
G
V
A
P
--
L
P
-----
K
I
D
G
K
D
-
A
----
Q
T
F
I
G
V
K
G
---
W
Y
----------
L
S
A
Y
S
K
Y
P
K
Y
A
T
E
L
M
Q
F
-
L
T
S
----
K
-
E
A
-
L
A
S
R
F
--------
K
E
T
G
E
I
P
P
Q
K
E
L
L
N
D
P
M
I
K
N
N
---
P
-------
V
V
N
--
G
F
A
K
Q
A
S
K
G
V
P
M
P
S
I
P
E
M
------
G
V
V
W
E
P
I
N
N
A
H
T
F
V
A
Q
G
--
K
Q
T
P
E
Q
A
L
N
D
A
V
K
I
M
K
E
K
I
Q
T
----------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.50
22%
-35
- C1 -
3K00
1
?
A:
[27-405]
--------------------------------
V
T
F
W
D
T
S
N
E
-
A
E
K
A
T
Y
-
Q
A
L
A
E
G
F
E
K
E
H
P
K
V
D
V
K
Y
V
N
V
P
F
G
--
E
A
N
A
K
F
K
---
N
A
A
G
-
G
-
N
SG
A
-
P
D
V
M
-
R
T
E
V
A
W
V
A
D
F
A
S
I
G
Y
L
A
P
L
DG
T
P
A
L
D
D
G
S
D
H
L
P
-----
Q
A
A
A
-
S
T
-
R
Y
E
G
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
E
V
P
G
S
V
A
E
L
K
T
A
A
A
E
I
T
E
K
T
G
A
-
T
G
---
L
--------
Y
L
-
R
G
D
D
----
P
Y
W
--------------
F
---
L
P
Y
L
Y
G
E
G
G
D
L
--
V
D
-
E
-----
K
N
-----
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
-
R
V
I
K
D
L
V
D
S
K
A
-----
A
I
--
T
D
A
S
D
-
G
W
-
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
--
P
W
A
I
E
D
V
K
A
GA
R
F
K
D
---
A
-----
G
N
L
G
V
A
-
P
--
V
P
-----
A
G
S
A
-
G
-
Q
----
G
S
P
Q
G
G
W
N
---
L
S
----------
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
A
K
V
Q
Q
-
Q
T
T
E
K
L
S
L
LPTR----
T
S
V
Y
E
V
P
S
V
A
D
N
E
M
V
K
F
F
---------------
K
P
--
A
V
D
K
A
V
E
R
----
P
W
I
A
E
G
------
N
A
L
F
E
P
I
R
L
Q
M
A
N
V
L
S
G
--
E
T
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.44
22%
-35
- C1 -
3K02
2
?
A:
[27-405]
--------------------------------
V
T
F
W
D
T
S
N
E
-
A
E
K
A
T
Y
-
Q
A
L
A
E
G
F
E
K
E
H
P
K
V
D
V
K
Y
V
N
V
P
F
G
--
E
A
N
A
K
F
K
---
N
A
A
G
-
G
-
N
SG
A
-
P
D
V
M
-
R
T
E
V
A
W
V
A
D
F
A
S
I
G
Y
L
A
P
L
DG
T
P
A
L
D
D
G
S
D
H
L
P
-----
Q
A
A
A
-
S
T
-
R
Y
E
G
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
E
V
P
G
S
V
A
E
L
K
T
A
A
A
E
I
T
E
K
T
G
A
-
T
G
---
L
--------
Y
L
-
R
G
D
D
----
P
Y
W
--------------
F
---
L
P
Y
L
Y
G
E
G
G
D
L
--
V
D
-
E
-----
K
N
-----
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
-
R
V
I
K
D
L
V
D
S
K
A
-----
A
I
--
T
D
A
S
D
-
G
W
-
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
--
P
W
A
I
E
D
V
K
A
GA
R
F
K
D
---
A
-----
G
N
L
G
V
A
-
P
--
V
P
-----
A
G
S
A
-
G
-
Q
----
G
S
P
Q
G
G
W
N
---
L
S
----------
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
A
K
V
Q
Q
-
Q
T
T
E
K
L
S
L
LPTR----
T
S
V
Y
E
V
P
S
V
A
D
N
E
M
V
K
F
F
---------------
K
P
--
A
V
D
K
A
V
E
R
----
P
W
I
A
E
G
------
N
A
L
F
E
P
I
R
L
Q
M
A
N
V
L
S
G
--
E
T
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.22
22%
-35
- C1 -
3JZJ
2
?
A:
[27-405]
--------------------------------
V
T
F
W
D
T
S
N
E
-
A
E
K
A
T
Y
-
Q
A
L
A
E
G
F
E
K
E
H
P
K
V
D
V
K
Y
V
N
V
P
F
G
--
E
A
N
A
K
F
K
---
N
A
A
G
-
G
-
N
SG
A
-
P
D
V
M
-
R
T
E
V
A
W
V
A
D
F
A
S
I
G
Y
L
A
P
L
DG
T
P
A
L
D
D
G
S
D
H
L
P
-----
Q
A
A
A
-
S
T
-
R
Y
E
G
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
E
V
P
G
S
V
A
E
L
K
T
A
A
A
E
I
T
E
K
T
G
A
-
T
G
---
L
--------
Y
L
-
R
G
D
D
----
P
Y
W
--------------
F
---
L
P
Y
L
Y
G
E
G
G
D
L
--
V
D
-
E
-----
K
N
-----
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
-
R
V
I
K
D
L
V
D
S
K
A
-----
A
I
--
T
D
A
S
D
-
G
W
-
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
--
P
W
A
I
E
D
V
K
A
GA
R
F
K
D
---
A
-----
G
N
L
G
V
A
-
P
--
V
P
-----
A
G
S
A
-
G
-
Q
----
G
S
P
Q
G
G
W
N
---
L
S
----------
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
A
K
V
Q
Q
-
Q
T
T
E
K
L
S
L
LPTR----
T
S
V
Y
E
V
P
S
V
A
D
N
E
M
V
K
F
F
---------------
K
P
--
A
V
D
K
A
V
E
R
----
P
W
I
A
E
G
------
N
A
L
F
E
P
I
R
L
Q
M
A
N
V
L
S
G
--
E
T
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
------------------------------------------------------------------------------------------
42
HHSearch
73.42
19%
-41
- C1 -
1ELJ
4
MALE_PYRFU
A:
[4-380]
----------------------------
E
E
G
K
V
V
I
W
H
A
M
Q
P
-
N
E
L
E
V
F
-
Q
S
L
A
E
E
Y
M
A
L
C
P
E
V
E
I
V
F
E
Q
K
P
----
N
L
E
D
A
L
K
--
A
A
I
P
T
-
G
-
Q
--
G
-
P
D
L
F
-
I
W
A
H
D
W
I
G
K
F
A
E
A
G
L
L
E
P
I
--
D
E
Y
V
T
E
D
--
L
-
L
N
E
F
A
P
M
A
Q
D
-
A
M
-
Q
Y
K
G
H
Y
Y
A
L
P
F
A
A
E
T
V
A
I
I
Y
N
K
E
M
V
S
E
----
P
P
---
K
T
F
D
E
M
K
A
I
M
E
K
Y
Y
D
P
-
A
N
---
E
--------
K
Y
-
G
I
A
W
----
P
I
N
-
A
---
Y
--
F
-----
I
---
S
A
I
A
Q
A
F
G
G
Y
Y
--
F
D
-
D
-----
K
T
-----
E
Q
P
G
L
D
K
P
E
T
I
E
G
F
K
F
F
F
T
E
I
W
P
Y
-
M
-----
A
P
--
T
G
D
----
Y
-
N
T
Q
Q
S
I
F
L
E
G
R
A
P
M
M
V
N
G
--
P
W
S
I
N
------
D
V
K
K
---
A
-----
G
I
N
F
G
V
V
P
--
L
P
-----
P
I
I
K
D
G
-
K
E
Y
W
P
R
P
Y
G
G
V
K
L
---
I
Y
----------
F
A
A
G
I
K
N
K
D
A
A
W
K
F
A
K
W
-
L
T
T
----
S
E
E
S
-
I
K
T
L
A
--------
L
E
L
G
Y
I
P
V
L
T
K
V
L
D
D
P
E
I
K
N
D
P
----------
V
I
Y
--
G
F
G
Q
A
V
Q
H
A
Y
L
M
P
K
S
P
K
M
------
S
A
V
W
G
G
V
D
G
A
I
N
E
I
L
Q
D
PQ
N
A
D
I
E
G
I
L
K
K
Y
Q
Q
E
I
L
N
N
M
Q
-----------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.19
22%
-31
- C1 -
3K01
1
?
A:
[30-408]
--------------------------------
V
T
F
W
D
T
S
N
E
-
A
E
K
A
T
Y
-
Q
A
L
A
E
G
F
E
K
E
H
P
K
V
D
V
K
Y
V
N
V
P
F
G
--
E
A
N
A
K
F
K
---
N
A
A
G
-
G
-
N
SG
A
-
P
D
V
M
-
R
T
E
V
A
W
V
A
D
F
A
S
I
G
Y
L
A
P
L
DG
T
P
A
L
D
D
G
S
D
H
L
P
-----
Q
A
A
A
-
S
T
-
R
Y
E
G
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
E
V
P
G
S
V
A
E
L
K
T
A
A
A
E
I
T
E
K
T
G
A
-
T
G
---
L
--------
Y
L
-
R
G
D
D
----
P
Y
W
--------------
F
---
L
P
Y
L
Y
G
E
G
G
D
L
--
V
D
-
E
-----
K
N
-----
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
-
R
V
I
K
D
L
V
D
S
K
A
-----
A
I
--
T
D
A
S
D
-
G
W
-
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
--
P
W
A
I
E
D
V
K
A
GA
R
F
K
D
---
A
-----
G
N
L
G
V
A
-
P
--
V
P
-----
A
G
S
A
-
G
-
Q
----
G
S
P
Q
G
G
W
N
---
L
S
----------
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
A
K
V
Q
Q
-
Q
T
T
E
K
L
S
L
LPTR----
T
S
V
Y
E
V
P
S
V
A
D
N
E
M
V
K
F
F
---------------
K
P
--
A
V
D
K
A
V
E
R
----
P
W
I
A
E
G
------
N
A
L
F
E
P
I
R
L
Q
M
A
N
V
L
S
G
--
E
T
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
------------------------------------------------------------------------------------------
47
HHSearch
73.14
21%
-44
- C1 -
2GHA
1
?
A:
[3-374]
------------------------------
P
K
L
T
I
W
C
S
E
K
---
Q
V
D
I
L
-
Q
K
L
G
E
E
F
K
A
K
Y
-
G
V
E
V
E
V
Q
Y
V
N
F
Q
--
D
I
K
S
K
F
L
--
T
A
A
P
E
-
G
-
Q
--
G
-
A
D
I
I
-
V
G
A
H
D
W
V
G
E
L
A
V
N
G
L
I
E
P
I
--
P
N
F
S
D
------
L
K
N
F
Y
E
T
A
L
N
-
A
F
-
S
Y
G
G
K
L
Y
G
I
P
Y
A
M
E
A
I
A
L
I
Y
N
K
D
Y
V
P
E
----
P
P
---
K
T
M
D
E
L
I
E
I
A
K
Q
I
D
E
E
F
G
G
---
E
--------
V
R
-
G
F
I
T
----
S
A
A
-
E
---
F
Y-
Y
-----
I
---
A
P
F
I
F
G
Y
G
G
Y
V
--
F
K
-
Q
-----
T
E
KGLDV
N
D
I
G
L
A
N
E
G
A
I
K
G
V
K
L
L
K
R
L
V
D
E
G
I
L
-----
D
P
--
S
D
N
-
Y
----
Q
I
M
D
S
M
F
R
E
G
Q
A
A
M
I
I
N
G
--
P
W
A
I
K
------
A
Y
K
D
---
A
-----
G
I
D
Y
G
V
A
P
--
I
P
-----
D
L
E
P
G
V
P
A
----
R
P
F
V
G
V
Q
G
---
F
M
----------
V
N
A
K
S
P
N
K
L
L
A
I
E
F
L
T
S
F
I
A
K
----
K
-
E
T
-
M
Y
R
I
Y
--------
L
G
D
P
R
L
P
S
R
K
D
V
L
E
L
--
V
K
D
N
P
----------
D
V
V
--
G
F
T
L
S
A
A
N
G
I
P
M
P
N
V
P
Q
M
------
A
A
V
W
A
A
M
N
D
A
L
N
L
V
V
N
G
--
K
A
T
V
E
E
A
L
K
N
A
V
E
R
I
K
A
Q
I
Q
-----------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.57
24%
-20
- C1 -
3ZKK
2
?
A:
[18-412]
----------------------------
D
D
K
T
I
T
F
W
H
N
A
S
A
-
G
E
G
R
Q
Y
W
E
N
L
A
K
S
F
E
E
A
N
P
G
T
K
V
E
I
Q
A
I
Q
N
E
--
D
F
A
G
K
L
Q
--
T
A
M
Q
D
P
A
-
S
--
G
-
P
D
V
F
M
S
L
G
G
A
K
T
K
E
M
I
D
A
G
Q
V
M
D
L
--
T
D
K
I
S
D
T
V
K
T
D
----
M
K
T
T
L
S
-
A
A
-
T
F
D
G
K
V
Y
G
V
P
V
S
V
E
P
G
G
M
W
Y
S
K
D
L
F
K
K
A
G
V
S
D
V
P
A
--
T
Y
E
E
L
L
A
D
A
K
K
L
K
D
S
-
G
T
---
D
--------
A
I
-
A
L
G
A
KD
A
W
P
A
A
-
H
---
W
--
Y
-----
Y
---
W
L
V
L
R
E
C
S
P
E
V
--
Y
D
-
K
-----
S
V
-----
Q
D
H
D
F
S
N
A
C
W
V
N
A
G
K
K
L
-
Q
E
L
K
D
L
K
V
FNDGF
L
T
--
T
T
A
Q
Q
-
G
A
-
N
S
S
A
G
L
L
A
N
H
K
A
A
M
E
L
M
G
--
A
W
E
P
G
------
V
L
K
D
---
L
-----
T
P
D
Q
K
P
-
M
--
A
D
-----
L
G
-------------
F
F
A
F
----
P
E
----------
V
A
G
G
E
G
E
P
G
A
L
M
G
G
V
T
Y
-
F
C
V
----
N
-
P
K
A
S
Q
T
S
I
--------
D
F
V
N
Y
M
G
E
K
K
N
Q
E
D
Y
A
K
A
F
S
T
I
P
A
S
EPARAVV
T
D
E
--
S
L
K
Q
V
I
E
Y
L
D
K
A
P
S
M
Q
L
W
M
D
T
A
L
G
T
N
I
G
N
A
L
N
A
A
V
V
N
M
L
S
G
--
Q
G
S
P
E
D
I
V
K
A
M
Q
D
A
A
Q
K
--------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.52
24%
-17
- C1 -
4C1T
3
?
A:
[18-412]
----------------------------
D
D
K
T
I
T
F
W
H
N
A
S
A
-
G
E
G
R
Q
Y
W
E
N
L
A
K
S
F
E
E
A
N
P
G
T
K
V
E
I
Q
A
I
Q
N
E
--
D
F
A
G
K
L
Q
--
T
A
M
Q
D
P
A
-
S
--
G
-
P
D
V
F
M
S
L
G
G
A
K
T
K
E
M
I
D
A
G
Q
V
M
D
L
--
T
D
K
I
S
D
T
V
K
T
D
----
M
K
T
T
L
S
-
A
A
-
T
F
D
G
K
V
Y
G
V
P
V
S
V
E
P
G
G
M
W
Y
S
K
D
L
F
K
K
A
G
V
S
D
V
P
A
--
T
Y
E
E
L
L
A
D
A
K
K
L
K
D
S
-
G
T
---
D
--------
A
I
-
A
L
G
A
KD
A
W
P
A
A
-
H
---
W
--
Y
-----
Y
---
W
L
V
L
R
E
C
S
P
E
V
--
Y
D
-
K
-----
S
V
-----
Q
D
H
D
F
S
N
A
C
W
V
N
A
G
K
K
L
-
Q
E
L
K
D
L
K
V
FNDGF
L
T
--
T
T
A
Q
Q
-
G
A
-
N
S
S
A
G
L
L
A
N
H
K
A
A
M
E
L
M
G
--
A
W
E
P
G
------
V
L
K
D
---
L
-----
T
P
D
Q
K
P
-
M
--
A
D
-----
L
G
-------------
F
F
A
F
----
P
E
----------
V
A
G
G
E
G
E
P
G
A
L
M
G
G
V
T
Y
-
F
C
V
----
N
-
P
K
A
S
Q
T
S
I
--------
D
F
V
N
Y
M
G
E
K
K
N
Q
E
D
Y
A
K
A
F
S
T
I
P
A
S
EPARAVV
T
D
E
--
S
L
K
Q
V
I
E
Y
L
D
K
A
P
S
M
Q
L
W
M
D
T
A
L
G
T
N
I
G
N
A
L
N
A
A
V
V
N
M
L
S
G
--
Q
G
S
P
E
D
I
V
K
A
M
Q
D
A
A
Q
K
--------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.25
24%
-21
- C1 -
3ZKL
3
?
A:
[18-412]
----------------------------
D
D
K
T
I
T
F
W
H
N
A
S
A
-
G
E
G
R
Q
Y
W
E
N
L
A
K
S
F
E
E
A
N
P
G
T
K
V
E
I
Q
A
I
Q
N
E
--
D
F
A
G
K
L
Q
--
T
A
M
Q
D
P
A
-
S
--
G
-
P
D
V
F
M
S
L
G
G
A
K
T
K
E
M
I
D
A
G
Q
V
M
D
L
--
T
D
K
I
S
D
T
V
K
T
D
----
M
K
T
T
L
S
-
A
A
-
T
F
D
G
K
V
Y
G
V
P
V
S
V
E
P
G
G
M
W
Y
S
K
D
L
F
K
K
A
G
V
S
D
V
P
A
--
T
Y
E
E
L
L
A
D
A
K
K
L
K
D
S
-
G
T
---
D
--------
A
I
-
A
L
G
A
KD
A
W
P
A
A
-
H
---
W
--
Y
-----
Y
---
W
L
V
L
R
E
C
S
P
E
V
--
Y
D
-
K
-----
S
V
-----
Q
D
H
D
F
S
N
A
C
W
V
N
A
G
K
K
L
-
Q
E
L
K
D
L
K
V
FNDGF
L
T
--
T
T
A
Q
Q
-
G
A
-
N
S
S
A
G
L
L
A
N
H
K
A
A
M
E
L
M
G
--
A
W
E
P
G
------
V
L
K
D
---
L
-----
T
P
D
Q
K
P
-
M
--
A
D
-----
L
G
-------------
F
F
A
F
----
P
E
----------
V
A
G
G
E
G
E
P
G
A
L
M
G
G
V
T
Y
-
F
C
V
----
N
-
P
K
A
S
Q
T
S
I
--------
D
F
V
N
Y
M
G
E
K
K
N
Q
E
D
Y
A
K
A
F
S
T
I
P
A
S
EPARAVV
T
D
E
--
S
L
K
Q
V
I
E
Y
L
D
K
A
P
S
M
Q
L
W
M
D
T
A
L
G
T
N
I
G
N
A
L
N
A
A
V
V
N
M
L
S
G
--
Q
G
S
P
E
D
I
V
K
A
M
Q
D
A
A
Q
K
--------------------------------------------------------------------------------------------
33
HHSearch
72.20
21%
-28
- C1 -
3K01
1
?
A:
[24-410]
--------------------------
V
E
L
S
G
T
V
T
F
W
D
T
S
N
E
-
A
E
K
A
T
Y
-
Q
A
L
A
E
G
F
E
K
E
H
P
K
V
D
V
K
Y
V
N
V
P
F
G
--
E
A
N
A
K
F
K
--
N
A
A
G
G
-
N
S
G
--
A
-
P
D
V
M
-
R
T
E
V
A
W
V
A
D
F
A
S
I
G
Y
L
A
P
L
--
D
G
T
P
A
L
D
D
---
G
S
D
H
L
P
Q
A
A
A
-
S
T
-
R
Y
E
G
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
E
V
P
---
G
S
V
A
E
L
K
T
A
A
A
E
I
T
E
K
-
T
----
G
--------
A
T
-
G
L
Y
L
----
R
G
D
D
P
---
Y
--
W
-----
F
---
L
P
Y
L
Y
G
E
G
G
D
L
--
V
D
-
E
-----
K
N
-----
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
R
V
I
K
D
L
V
D
S
K
A
A
-----
I
T
--
D
A
S
-
D
-
G
W
-
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
--
P
W
A
I
E
------
D
V
K
A
---
G
ARFKD
A
G
N
L
G
V
A
P
--
V
P
-----
A
G
S
A
-
G
-
Q
----
G
S
P
Q
G
G
W
N
---
L
S
----------
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
----
A
-
K
V
-
Q
Q
Q
T
T
--------
E
K
L
S
L
L
P
T
R
T
S
V
Y
E
V
P
S
V
A
D
N
---
E
-------
M
V
K
--
F
F
K
P
A
V
D
K
A
V
E
R
P
W
I
A
E
G
------
N
A
L
F
E
P
I
R
L
Q
M
A
N
V
L
S
G
--
E
T
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
K
D
----------------------------------------------------------------------------------------