@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0182: (2016-03-12 )
MSKFTKLMQGYLHLIEGKNEKIKPILLETKPNFTTDSVLETASWLWLSSKINHYDREEVEPVIAFLVENWNRPEKSIWGSAENDIYLATISSVYSALLDVKNTFPKPELQQTITIIRDYCFDNLLKGDSILTGFNTRKVSTDQLLSVLPFGLFSPEDLVMVAAVGKMEQQLVQDDGVLPYSGAPRVNSFATALMALYFLEKSDQDKALHYLNMAMKMEDNDELGAIFIEINQAFRAMESEVTAHISHDPFGHENRYEQQLTERTPHYPETEMHFSAACEVISEVEPIQVELVLKEKDWTILCEKKEKNDVQIWEALVPPLEEVGEYTYYFQATMKDQTTLTSDDYKVEPIWKHWSEEAAICETEQGLMVLFKENPSSIIPVEFTVKSDELVIGLKPSFEASNVKTKSSGQLKKDDLEIIVSNNPVRLEVHFKGKLILESHKIYPALQWYTDKTGTINKVKLHLDAPKEEEYYGFGERYNALGQRGNVLDCFVYNQYRDQGTRTYIPMPFYHTNRDYSVFVDTARYTSFDLGNQLADKHTITVEINGCDTDICLLMGDIRSAVANYMKKTGKPAMVPVWALGPWMSSNNWDRESVVRNEVETTQELQIPSTVVVLEQWSDEATYYMFNDAEYDEKAPSEAYSYDEIRFPSWGRWPDPKGMVDYIHDNKMKLILWQIPIQKYLNRQQHPLKDREEAYMIEKGYVVKNPDGSPYRIPENWFTESLIMDFSNEEGKKWWFDKRQYLIDIGVDGFKTDGGEFVFGEGLQFADGRRGDEMRNLYPNDYVEAYYQFAQQNEGMTFSRAGYTGAQNFPAHWAGDERSTFDAFRRSLIAGLSAGFSGIPFWSFDFAGFNGDIPTAELFIRSAEMATFCPIMQYHAESKAEFNQDRTPWNIASRTGDDSVIPIYRHFANVRMNILPYIYNESLKCVETGLPMMRALLLDYKEDPRVSDMYDQYLFGEAMLIAPVIEDGVRSREVYLPEGTWYDFWNGTKVSGPTLRKCKADKEEIPVFVRGGKAVLCNVDATLKLGSWVGNTVEEYDTPLLKVYLDGDFTEEITDHLFGKWLVKVTENADEVIVSVQTNTASYEVEVIGTTKKVQIKKGR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.........280.......290---.......300.......310.......320.......330.......340.......350........360.......370.......380...--..---..390.......400---.--------------.----------...-----.------...410.---------......420...-....430.--........440.---......450.......460.......470......-.480--..---..-....490-.--....--..---.-.500-..---......510-----..----.-----....520.......530....-----------------------------------------------------------------------------------------------------------------------------------------------------...540...-....---550....-.-..560..-.....570.......580.....---..590.--........600.......610...-------.-...620.......630.......640.......650.......660.......670....-...680.......690.......700.....-..-710....-...---------------------720-.........730.......740..--------.-.....750.....-..760--------------------------------.------------------------------------------.------------------------------------.-----.----..----.--.770--------------------------------.......780......--.790---.----...----...--.800.......810-.-.......820.......830.......840.......-850----------------------.-----......860.......870.....-..880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......-980.....-----..--990-........1000......1010....-----..1020-------........1030......1040...-..---.1050.....-----.1060.......1070......1080----.---------------------......--1090......1100---------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
K
F
T
K
L
M
Q
G
Y
L
H
L
IEGKNE
K
I
K
P
I
L
L
ETKPNFT
T
D
S
V
L
E
T
A
S
W
L
W
L
S
SKINHY
D
R
E
E
V
E
P
V
I
A
F
L
V
ENWNR
P
E
K
SIWGSAEN
D
I
Y
L
A
T
I
S
S
V
Y
S
A
L
L
D
V
KNTFP
K
P
E
L
Q
Q
T
I
T
I
I
R
D
Y
C
F
D
N
L
LKGD
S
I
L
TGFNTRKV
S
T
D
Q
L
L
S
V
LPFGLFSPE
D
L
V
M
V
A
A
V
G
K
M
E
Q
Q
L
V
QDDGVLPYSGAP
R
V
N
S
F
A
T
A
L
M
A
L
Y
F
LEKSDQ
D
K
A
L
H
Y
L
N
M
A
MKMEDNDEL
G
A
I
F
I
E
I
N
Q
A
F
R
A
M
E
S
E
V
T
A
HISHDPFGH
E
N
R
Y
E
Q
Q
L
T
ERTPHYPE
T
--
E
M
H
F
S
A
A
C
E
V
I
SEVE
P
I
Q
V
E
L
V
---
L
KEK
D
W
T
I
L
C
EKKEKN
D
V
Q
I
W
E
A
LVP
P
L
E
E
VGE
Y
T
Y
Y
F
Q
A
TMKDQTTLTSDDYKV
E
P
I
-
W
K
HWSEEAAICETEQ
G
L
M
V
L
F
KENPS
S
I
I
P
V
E
F
T
V
--KS---D
E
L
V
I
GLKPSFEA-----S--------------N----------VKT-----K------SSGQLKK---------D
D
L
E
I
I
VSNN
P
V
-
R
L
E
V
H
--F--K
G
K
L
I
L
ESHKI
Y
---
P
A
L
Q
W
YTDKTG
T
I
N
K
V
K
L
H
LDAPKE
E
E
YYGF
G
E
R
Y
-
N
A
L---GQ---RG-
N
V
L
D
C
---
F
--
V
Y
N
Q
--YR---D-QGT--
R
T
---
Y
I
PMP
F
Y
HT-----NR----
D
-----
Y
S
V
F
V
DTARYTSFDLGNQLAD-----------------------------------------------------------------------------------------------------------------------------------------------------
K
H
T
I
T
V
E
IN-GCD
T
---
D
I
C
L
L
M
G
-
D
-
I
R
S
A
V
A
N
-
Y
M
K
KTGKP
A
M
V
P
V
WALGPWMSSN---NW
D
--
R
--
E
S
V
V
R
N
E
VETTQELQIP
S
T
V
V
V
L
E-------Q-WSDE
A
T
Y
Y
M
FNDAEYDEKAPSEAYSYDEIRFPSWGRWPDP
K
G
M
V
D
YIHDN
K
M
K
L
I
L
W
QI
P
-
I
Q
K
Y
L
N
RQQHPL
K
D
R
E
E
A
Y
M
I
EK
G
Y
V
V
KNPD-GS-PYRI
P
E
N
-
W
F
T
---------------------
E
---
S
L
I
M
DFSNEEGK
K
W
W
FDK
R
Q
Y
-
L
I
--------
D
-IGVDGFKTDGG
E
F
-
V
FGE---------------------------------G------------------------------------------L------------------------------------Q-----F----AD----G--RRG
D
--------------------------------
E
M
R
NLY
P
N
D
Y
V
E
A
Y
Y
Q
--
F
A
Q
----Q----NEG----
M
T
F
--SRAGYTGAQNFP-A-H-WAGDER
S
T
F
D
A
F
R
R
S
L
I
A
G
L
S
AGFSGI
P
F
W
S
F
DFAGF-NGD----------------------I-----
P
T
A
E
L
F
I
RSA
E
M
A
T
F
C
P
I
M
Q
Y
HAE-SKAEFNQDRTPWNIASRTGDD
S
V
I
P
I
Y
R
H
F
A
N
V
R
M
N
I
L
P
Y
I
YNE
S
L
K
C
V
E
T
G
L
P
M
M
R
A
L
L
L
DYKEDP
R
V
S
D
M
Y
D
Q
Y
LFGE
A
M
L
I
A
P
V
I
E
DGVRS
R
E
V
YLPEG-
T
W
YDFWNG-----TK--V-S-GP
T
L
R
KCKA
D
K
E
EI
P
V
F
V
RGG
K
A
V
L
C
-----NV
D
A
---------
T
L
K
L
G
S
WVGN
T
V
E
E
YDT
P
L
L
K
V
Y
LD-GD---
F
T
E
E
I
T
D
H
L
F
-----
G
K
W
-
L
V
KVTENA
D
E
V
I
V
S
V
QTNT
A
S
-----
Y
---------------------
E
V
E
V
I
G--T
T
K
K
V
Q
IKKGR------------------------------------
1
PsiBlast_PDB
94.39
35%
-61
- C1 -
4KMQ
3
?
A:
[30-868]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
P
Y
G
D
D
D
L
Y
T
V
Q
P
T
E
R
S
P
R
D
P
K
A
G
E
D
V
I
L
N
I
T
T
W
P
I
E
N
G
Q
D
V
W
V
E
W
T
K
NG
V
A
Q
E
N
V
T
A
A
Y
D
Y
N
S
G
N
N
T
-
Y
W
K
A
D
L
G
K
F
E
K
G
D
E
I
T
Y
T
T
K
G
S
T
N
G
G
T
A
Y
E
S
G
P
F
T
F
Y
V
T
D
W
E
Y
V
Q
D
V
T
S
V
V
D
N
G
D
S
I
T
L
N
M
T
A
T
A
G
D
F
S
P
K
L
Y
L
S
F
E
D
L
---
D
T
L
R
M
E
L
S
P
T
G
K
E
-----
T
--------------
G
----------
H
A
G
-----
K
------
S
G
Y
T
V
E
D
T
AE
K
V
T
V
T
T
E
D
L
S
I
E
I
Q
K
S
P
Y
-
R
M
E
V
H
Q
-
A
--
D
G
T
L
L
T
S
E
Y
T
T
A
---
N
S
L
G
W
L
T
D
G
K
N
V
I
N
Q
Y
Q
N
N
F
M
T
P
S
D
E
A
F
Y
G
F
G
E
R
Y
-
D
T
I
---
N
Q
---
R
G
-
K
D
V
E
T
---
Y
--
V
Y
N
E
--
Y
Q
---
D
-
Q
A
Q
TE
R
T
---
Y
L
A
V
P
F
F
V
S
-----
A
N
----
K
-----
Y
G
M
Y
V
N
S
D
F
H
S
Q
F
Q
M
A
S
K
V
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
S
F
V
L
D
N
D
-
G
D
M
T
N
M
L
D
Y
Y
V
I
S
G
K
D
-
Q
N
D
I
V
N
N
-
Y
T
D
I
T
G
K
T
T
L
L
P
K
W
A
F
G
L
W
M
S
A
N
---
E
W
D
--
R
--
E
S
D
V
S
S
A
L
S
N
A
K
A
N
D
I
P
A
T
G
F
V
L
E
-------
Q
-
W
S
D
E
E
T
Y
Y
I
W
N
N
A
T
Y
T
A
K
K
N
G
E
A
F
S
Y
D
D
F
T
F
N
--
G
K
W
T
D
P
K
G
M
V
D
S
V
H
D
A
G
M
N
I
V
L
W
Q
V
P
-
V
L
K
-
D
D
G
T
V
Y
E
Q
R
D
N
D
E
E
Y
M
I
S
Q
G
Y
S
A
D
D
G
T
-
G
A
-
P
Y
R
V
P
A
S
Q
W
F
G
---------------------
N
---
G
I
L
L
D
F
T
N
K
D
A
V
D
W
W
T
S
Q
R
E
Y
-
L
L
T-------
E
-
V
G
I
D
G
F
K
T
D
G
G
E
M
-
V
W
G
R
---------------------------------
D
------------------------------------------
T
------------------------------------
T
-----
F
----
S
N
----
G
--
E
K
G
Q
--------------------------------
E
M
R
N
R
Y
P
T
D
Y
V
S
S
Y
F
D
--
F
A
K
S
I
--
N
----
P
E
A
----
V
S
F
--
S
R
S
G
T
S
G
A
Q
K
S
G
-
I
-
Y
-
W
S
G
D
Q
T
S
T
F
D
S
F
Q
A
S
L
K
A
G
L
S
A
S
T
S
G
V
S
Y
W
A
W
D
M
A
G
F
-
T
G
D
----------------------
Y
-----
P
T
A
E
L
Y
K
R
A
T
A
M
A
A
F
A
P
I
M
Q
F
H
S
E
K
S
D
P
S
P
S
E
E
R
S
P
W
N
A
V
A
R
T
G
D
E
T
I
L
P
T
F
Q
K
Y
L
Y
T
R
M
N
L
L
P
Y
I
Y
T
A
A
K
D
T
A
D
N
G
K
S
M
M
R
Q
M
A
M
D
Y
P
E
D
V
N
A
R
D
L
D
E
Q
Y
M
F
G
D
D
L
L
V
A
P
I
V
Q
E
G
Q
T
E
K
E
V
Y
L
P
E
G
-
E
W
V
D
I
W
N
G
-----
G
V
--
H
-
P
-
G
G
E
T
I
S
Y
Y
A
D
V
D
T
L
P
V
F
A
K
A
G
A
I
I
P
M
-----
N
M
T
D
---------
G
Y
Q
L
G
Q
N
V
G
N
D
L
K
S
Y
D
N
L
T
F
R
V
Y
P
S
-
G
D
---
S
E
Y
S
F
Y
D
D
V
N
-----
G
----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.06
35%
-61
- C1 -
4KWU
11
?
A:
[30-867]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
P
Y
G
D
D
D
L
Y
T
V
Q
P
T
E
R
S
P
R
D
P
K
A
G
E
D
V
I
L
N
I
T
T
W
P
I
E
N
G
Q
D
V
W
V
E
W
T
K
NG
V
A
Q
E
N
V
T
A
A
Y
D
Y
N
S
G
N
N
T
-
Y
W
K
A
D
L
G
K
F
E
K
G
D
E
I
T
Y
T
T
K
G
S
T
N
G
G
T
A
Y
E
S
G
P
F
T
F
Y
V
T
D
W
E
Y
V
Q
D
V
T
S
V
V
D
N
G
D
S
I
T
L
N
M
T
A
T
A
G
D
F
S
P
K
L
Y
L
S
F
E
D
L
---
D
T
L
R
M
E
L
S
P
T
G
K
E
-----
T
--------------
G
----------
H
A
G
-----
K
------
S
G
Y
T
V
E
D
T
AE
K
V
T
V
T
T
E
D
L
S
I
E
I
Q
K
S
P
Y
-
R
M
E
V
H
Q
-
A
--
D
G
T
L
L
T
S
E
Y
T
T
A
---
N
S
L
G
W
L
T
D
G
K
N
V
I
N
Q
Y
Q
N
N
F
M
T
P
S
D
E
A
F
Y
G
F
G
E
R
Y
-
D
T
I
---
N
Q
---
R
G
-
K
D
V
E
T
---
Y
--
V
Y
N
E
--
Y
Q
---
D
-
Q
A
Q
TE
R
T
---
Y
L
A
V
P
F
F
V
S
-----
A
N
----
K
-----
Y
G
M
Y
V
N
S
D
F
H
S
Q
F
Q
M
A
S
K
V
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
S
F
V
L
D
N
D
-
G
D
M
T
N
M
L
D
Y
Y
V
I
S
G
K
D
-
Q
N
D
I
V
N
N
-
Y
T
D
I
T
G
K
T
T
L
L
P
K
W
A
F
G
L
W
M
S
A
N
---
E
W
D
--
R
--
E
S
D
V
S
S
A
L
S
N
A
K
A
N
D
I
P
A
T
G
F
V
L
E
-------
Q
-
W
S
D
E
E
T
Y
Y
I
W
N
N
A
T
Y
T
A
K
K
N
G
E
A
F
S
Y
D
D
F
T
F
N
--
G
K
W
T
D
P
K
G
M
V
D
S
V
H
D
A
G
M
N
I
V
L
W
Q
V
P
-
V
L
K
-
D
D
G
T
V
Y
E
Q
R
D
N
D
E
E
Y
M
I
S
Q
G
Y
S
A
D
D
G
T
-
G
A
-
P
Y
R
V
P
A
S
Q
W
F
G
---------------------
N
---
G
I
L
L
D
F
T
N
K
D
A
V
D
W
W
T
S
Q
R
E
Y
-
L
L
T-------
E
-
V
G
I
D
G
F
K
T
D
G
G
E
M
-
V
W
G
R
---------------------------------
D
------------------------------------------
T
------------------------------------
T
-----
F
----
S
N
----
G
--
E
K
G
Q
--------------------------------
E
M
R
N
R
Y
P
T
D
Y
V
S
S
Y
F
D
--
F
A
K
S
I
--
N
----
P
E
A
----
V
S
F
--
S
R
S
G
T
S
G
A
Q
K
S
G
-
I
-
Y
-
W
S
G
D
Q
T
S
T
F
D
S
F
Q
A
S
L
K
A
G
L
S
A
S
T
S
G
V
S
Y
W
A
W
D
M
A
G
F
-
T
G
D
----------------------
Y
-----
P
T
A
E
L
Y
K
R
A
T
A
M
A
A
F
A
P
I
M
Q
F
H
S
E
K
S
D
P
S
P
S
E
E
R
S
P
W
N
A
V
A
R
T
G
D
E
T
I
L
P
T
F
Q
K
Y
L
Y
T
R
M
N
L
L
P
Y
I
Y
T
A
A
K
D
T
A
D
N
G
K
S
M
M
R
Q
M
A
M
D
Y
P
E
D
V
N
A
R
D
L
D
E
Q
Y
M
F
G
D
D
L
L
V
A
P
I
V
Q
E
G
Q
T
E
K
E
V
Y
L
P
E
G
-
E
W
V
D
I
W
N
G
-----
G
V
--
H
-
P
-
G
G
E
T
I
S
Y
Y
A
D
V
D
T
L
P
V
F
A
K
A
G
A
I
I
P
M
-----
N
M
T
D
---------
G
Y
Q
L
G
Q
N
V
G
N
D
L
K
S
Y
D
N
L
T
F
R
V
Y
P
S
-
G
D
---
S
E
Y
S
F
Y
D
D
V
N
-----
G
----------------------------------------------------------------------------------------------------------
46
Fugue
79.94
22%
-67
- C1 -
4BA0
12
OL4AG_CELJU
A:
[35-817]
---------------------------------------------------------------
A
V
F
Y
K
E
H
K
L
R
N
D
G
L
V
I
T
T
N
Q
G
N
I
R
L
Q
F
K
S
---------------------------------------------------------------
E
A
A
I
E
V
L
Y
-------------------------------------------------------------------------------------------------------
R
A
D
S
--
K
Q
L
P
S
F
A
L
A
--------------------------------------------------------------------------------------------------
Q
P
E
S
A
I
K
A
Q
L
T
E
--
T
E
---
N
H
L
Q
F
S
G
G
T
--------------------------------------------------------------------
L
T
A
R
I
Q
K
R
P
F
-
A
I
S
Y
Y
--
R
--
D
S
E
L
L
L
A
E
E
S
G
F
---
Q
V
-----------
N
K
I
N
F
R
F
Y
L
S
P
G
E
K
I
L
G
G
G
Q
R
I
-
L
G
M
---
D
R
---
R
G
-
Q
R
F
P
L
---
Y
--
N
R
A
H
YG
Y
S
---
D
-
H
S
G
--
Q
M
---
Y
F
G
L
P
A
I
M
S
-----
S
K
----
Q
-----
Y
I
L
V
F
D
N
S
A
S
G
A
M
D
I
G
K
T
--
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
D
I
L
Q
L
E
A
K
-
S
G
R
S
---
A
Y
I
L
V
A
G
N
S
-
Y
P
S
L
I
E
N
-
F
T
Q
V
T
G
R
Q
P
L
P
P
R
W
A
L
G
S
F
A
S
R
F
---
G
Y
R
--
S
--
E
A
E
T
R
A
T
V
Q
K
Y
K
T
E
D
F
P
L
D
T
I
V
L
D
---------------
L
Y
W
F
G
K
---
D
I
K
G
H
M
G
N
L
D
W
D
K
------
E
N
F
P
T
P
L
D
M
M
A
D
F
K
Q
Q
G
V
K
T
V
L
I
T
E
P
-
F
V
L
--------
T
S
S
K
R
W
D
D
A
V
K
A
K
A
L
A
K
D
P
Q
-
G
Q
-
P
K
A
-
F
E
L
-
Y
F
G
---------------------
N
---
G
G
I
I
D
V
F
S
K
E
G
S
R
W
F
S
S
I
Y
K
D
-
L
S
--------
K
-
Q
G
V
A
G
W
W
G
D
L
G
E
P
E
M
H
P
E
---------------------------------
D
------------------------------------------
T
------------------------------------
Q
-----
H
----
A
I
----
G
--
D
-
A
D
--------------------------------
T
V
H
N
A
Y
G
H
R
W
A
E
M
L
Y
Q
--
Q
Q
L
----
D
----
Q
F
P
E
L
R
P
F
I
M
--
M
R
A
G
F
V
G
S
Q
R
Y
G
-
M
-
I
P
W
T
G
D
V
S
R
T
W
G
G
L
A
S
Q
V
E
L
A
L
Q
M
S
L
L
G
F
G
Y
I
H
S
D
L
G
G
F
A
D
G
E
----------------------
T
-----
L
D
K
E
M
Y
I
R
W
L
Q
Y
G
V
F
Q
P
V
Y
R
P
H
G
Q
-
D
H
I
----
P
S
E
P
V
F
Q
-----
D
E
E
T
K
A
I
L
R
P
L
V
K
L
R
Y
R
M
L
P
Y
I
Y
T
A
A
Y
Q
N
T
L
T
G
M
P
L
M
R
P
L
F
F
S
D
E
K
N
P
A
L
I
D
N
K
T
S
Y
F
W
G
D
S
L
L
V
T
P
I
T
Q
A
G
V
E
S
V
S
I
P
A
P
K
G
-
V
W
F
D
F
W
K
D
-----
T
R
--
Y
-
Q
T
D
G
A
P
L
T
L
P
T
D
L
H
T
I
P
V
L
V
K
A
G
A
F
M
P
Y
-----
V
P
A
V
STTEDYRSD
S
L
E
I
H
Y
Y
A
D
A
S
V
P
---
L
A
Q
G
E
I
F
E
D
D
G
K
---
D
P
N
S
I
K
R
N
Q
F
-----
D
L
L
-
T
L
Q
A
T
H
T
D
N
Q
L
H
F
Q
L
A
R
T
G
K
G
-----
Y
RGMPERRA
T
T
L
V
I
H
NASDQYQ
H
L
D
I
N
G
--
K
T
I
A
I
A
Q
A
D
C
A
STPAL
A
C
Y
D
QERR
Q
L
Q
L
V
F
T
W
G
R
E
A
L
N
L
R
L
H
K----
44
Fugue
76.58
24%
-58
- C1 -
1XSJ
4
XYLS_ECOLI
A:
[1-773]
----
M
K
I
S
D
G
N
W
L
I
Q
P
G
------------------------------------
L
N
L
I
H
P
L
Q
V
F
E
V
E
Q
Q
D
----------------
N
E
M
V
V
Y
A
A
P
R
D
V
R
E
R
T
W
Q
L
D
T
P
L
F
T
L
R
F
F
S
P
Q
E
---------------------------------------------------------------------------------------------------------
G
I
V
G
V
R
I
E
H
F
Q
G
A
L
N
N
G
P
H
Y
P
L
N
I
L
Q
------------------------------------------------------------------------------------------
D
V
K
V
T
I
E
N
T
-------------------------------------
E
R
Y
A
E
F
--
K
S
---
G
N
L
S
A
R
V
S
--------------------------------------------------------------------------
K
G
E
F
W
-
S
L
D
F
L
--
R
--
N
G
E
R
I
T
G
S
Q
V
-----
K
N
N
G
Y
V
Q
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
---
V
R
---
N
G
-
Q
T
V
E
T
---
W
--
N
R
D
G
--
G
T
---
S
-
T
E
Q
---
A
---
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
--
K
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
V
Q
F
S
V
E
-
S
E
Y
L
---
E
Y
F
V
I
D
G
P
T
-
P
K
A
V
L
D
R
-
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
---
F
T
T
--
N
YD
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
---------------------
D
C
F
W
M
K
A
F
Q
W
C
D
F
E
W
D
P
------
L
T
F
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
-
Y
I
G
Q
--------
K
S
P
V
F
K
E
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
S
-
L
W
Q
-
W
D
K
-
W
Q
P
---------------------
G
---
L
A
I
Y
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
-
L
V
--------
A
-
M
G
V
D
C
F
K
T
D
F
G
E
R
-
I
-
P
T
---------------------------------
D
------------------------------------------
V
------------------------------------
Q
-----
W
----
F
D
----
G
--
S
D
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
--
V
L
K
----
D
T
VGE
E
E
A
----
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
F
P
-
V
-
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
-
E
N
T
----------------------------
A
P
A
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
------
K
S
Y
R
V
P
W
A
Y
-----
D
D
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
F
P
D
D
P
A
C
D
Y
L
D
R
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
W
T
H
L
W
H
N
-----
D
E
--
L
-
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
-------------
T
---------
L
L
A
L
G
N
N
D
Q
R
P
D
Y
V
W
H
E
G
T
A
F
H
L
F
N
-
L
Q
---
D
G
H
E
A
V
C
E
V
P
A
ADGS
V
I
F
-
T
L
K
A
A
R
T
G
N
T
I
T
V
T
G
A
G
E
A
K
N
-----
W
---------------------
T
L
C
L
R
N
--
V
V
K
V
N
G
L
Q
D
G
S
Q
A
E
S
EQ
G
L
V
V
K
P
QGN
A
L
T
I
T
L
H--------------
23
HHSearch
76.44
25%
-63
* C1 *
2F2H
2
XYLS_ECOLI
A:
[53-740]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
L
R
F
F
S
--
P
Q
E--
G
I
V
G
V
R
I
E
H
F
Q
G
A
LNNGP
H
Y-------------
P
LNILQDV
K
V
T
I
E
N
T
----
E
------
R
Y
A
E
F
K
S
---------
G
N
L
S
A
R
V
S
K
G
E
F
W
S
L
D
F
L
--
R
--
N
G
E
R
I
T
G
S
Q
V
K
N
---
N
G
Y
V
--
Q
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
---
V
R
---
N
G
-
Q
T
V
E
T
---
W
--
N
R
D
G
--
G
----
T
-
S
T
E
--
Q
A
---
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Q
F
S
V
E
-
S
E
Y
L
---
E
Y
F
V
I
D
G
P
T
-
P
K
A
V
L
D
R
-
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
---
F
T
T
NY
D
--
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
C------
F
-
W
M
K
A
--------------
F
Q
W
C
D
F
E
W
D
P
------
L
T
F
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
-
Y
I
G
Q
K
----
S
P
V
----
F
K
E
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
S
-
L
W
Q
W
-
D
K
-
W
Q
P
---------------------
G
---
L
A
I
Y
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
-
L
V
--------
A
-
M
G
V
D
C
F
K
T
D
F
G
E
R
-
I
P
T
----------------------------------
D
------------------------------------------
V
------------------------------------
Q
-----
W
----
F
D
----
G
--
S
D
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
--
V
L
K
----
D
TVGE
E
E
A
----
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
F
P
-
V
-
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
-
E
N
T
----------------------------
A
P
A
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
-
K
-----
S
Y
R
V
P
W
A
Y
D
D
-----
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
F
P
D
D
P
A
C
D
Y
L
D
R
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
W
T
H
L
W
H
N
-----
D
E
--
L
-
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
T
L
L
A
L
-----
G
N
N
D
---------
Q
R
P
-
D
Y
------
V
W
H
E
G
T
A
F
H
L
F
N
L
-
Q
D
G
H
E
A
V
C
E
V
P
A
A
D
G
-----
S
V
I
F
T
L
K
A
A
R
T
G
N
T
I
T
V
T
G
A
G
E
A
K
N
-----
W
---------------------
T
L
C
L
R
N
-------------------------------------------------
26
HHSearch
73.57
22%
-59
- C1 -
2XVL
12
?
A:
[67-913]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
L
Q
V
--
M
G
E--
R
I
I
R
V
T
A
L
P
G
T
D
F
GIVP-
E
SIQVVAKPATN
V
P
F
S
----------
V
D
Q
A
----
G
------
E
K
L
V
L
K
T
---------
S
Q
V
S
A
E
V
S
L
L
D
G
-
T
V
S
F
R
--
D
A-
K
G
N
V
L
L
Q
E
E
N
R
G
T
F
S
P
V
I
H
D
P
D
P
V
D
A
D
S
Y
A
L
R
Q
E
F
N
R
G
S
D
E
G
F
F
G
L
G
Q
H
Q
N
G
Q
V
---
N
Y
---
A
G
-
E
N
V
E
L
---
T
--
T
Y
----------------
N
L
---
V
I
S
I
P
F
L
V
S
-----
S
R
----
N
-----
Y
G
L
L
W
D
N
N
S
I
T
R
F
G
D
P
R
E
A
Q
P
LNQS
L
K
L
Y
D
AEGKEG
G
L
T
V
R
Y
F
VGDELK
L
T
R
V
E
ADFNHQFYKQGNELENPFPEEV
A
G
A
Y
K
N
NT
L
R
I
E
L
E
G
S
I
E
A
QAT
G
K
H
Q
F
K
M
Y
N
S
G
Y
A
Q
L
S
L
DGEVV
L
D
R
W
R
MNW
N
P
W
Y
H
N
F
Y
R
E
L
N
AG
D
K
H
K
L
K
V
S
W
KPDG
G
F
F
H
L
R
H
L
D
P
LPANE
Q
H
E
L
S
L
A
S
E
T
G
K
A
I
---
D
Y
Y
F
V
A
G
D
T
-
K
D
D
I
I
S
G
-
Y
R
Q
L
T
G
K
S
V
M
L
P
K
W
A
Y
G
F
W
Q
S
R
E
---
R
Y
K
--
S
--
S
D
E
I
I
Q
N
L
K
E
Y
R
D
R
K
I
P
I
D
N
I
V
L
D
W
------
S
-
Y
W
P
--------------
E
D
A
W
G
S
H
D
F
D
K
------
Q
F
F
P
D
P
K
A
L
V
D
K
V
H
A
M
N
A
Q
I
M
I
S
V
W
P
-
K
F
Y
P
T
----
T
D
----
N
Y
K
E
L
N
A
K
G
F
M
F
N
R
N
L
-
D
E
-
K
---
N
L
D
-
W
I
G
---------------------
K
G
Y
L
N
A
F
Y
D
P
F
S
P
E
A
T
A
I
F
W
K
Q
I
R
D
K
I
N
--------
V
-
H
G
F
D
A
W
W
L
D
A
V
E
P
-
D
I
H
S
---------------------------------
N
------------------------------------------
L
------------------------------------
T
F
E
K
R
K
W
L
M
TP
N
A
----
R
--
G
N
G
A
--------------------------------
E
I
F
N
A
Y
A
V
P
H
A
E
G
V
Y
Q
--
G
E
L
A
T
DG
D
----
K
R
S
----
F
I
L
--
T
R
S
G
F
G
G
I
Q
R
T
G
S
A
-
I
-
W
S
G
D
I
V
S
R
W
S
D
M
K
D
Q
I
A
A
G
I
G
T
N
L
A
G
V
T
N
W
T
F
D
I
G
G
F
-
T
P
E
DRFRHGKKGFVGSWTALDAEQ
V
D
-----
E
W
Q
E
L
N
T
R
W
Y
Q
F
G
A
F
V
P
L
Y
R
S
H
G
Q
-
N
-----
P
Y
R
E
I
F
N
I
A
D
E
G
--
T
E
V
Y
N
A
M
V
W
Y
T
K
L
R
Y
Y
L
M
P
Y
I
Y
T
L
G
G
D
T
Y
H
K
D
G
T
I
M
R
G
L
V
M
D
F
P
N
D
R
K
A
W
D
I
N
T
Q
Y
M
F
G
P
A
F
L
V
N
P
V
Y
E
Y
K
A
R
S
R
D
V
Y
L
P
A
G
S
D
W
Y
N
F
Y
T
G
-----
E
K
--
L
-
A
-
G
G
Q
T
I
T
A
D
A
P
L
A
R
V
P
L
F
V
K
A
G
A
I
V
P
T
-----
G
P
L
I
---------
Q
H
V
-
D
E
------
G
L
N
S
P
L
L
I
T
V
Y
T
G
-
A
N
---
G
S
F
D
I
Y
E
D
D
G
-----
R
S
L
--------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.34
30%
-72
- C1 -
2F2H
2
XYLS_ECOLI
A:
[154-664]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
---
V
R
---
N
G
-
Q
T
V
E
T
---
W
--------
N
R
---
D
-
G
G
T
--
S
T
EQA
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Q
F
S
V
E
S
E
---
Y
L
---
E
Y
F
V
I
D
G
-
P
-
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
-
W
C
D
--------------------
F
E
W
D
P
L
T
F
P
------
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
----
I
N
P
Y
I
G
Q
K
S
P
V
F
K
E
-----
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
S
-
L
W
Q
W
-
D
K
-
W
Q
P
---------------------
G
---
L
A
I
Y
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
-
L
V
--------
A
-
M
G
V
D
C
F
K
T
D
F
G
E
R
-
I
P
T
D
----------------------------------------------------------------------------
V
------------------------------------
Q
-----
W
----
F
D
----
G
--
S
D
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
--
V
L
K
D
TVG
E
----
E
E
A
----
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
F
P
-
V
-
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
-
E
N
T
----------------------
A
-----
P
-
A
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
-
K
S
Y
-----
R
V
P
W
A
Y
-----
D
D
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
F
P
D
D
P
A
C
D
Y
L
D
R
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
-
A
G
D
V
Q
F
Y
L
P
E
G
-
R
W
T
H
L
W
H
N
-----
D
E
--
L
-
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.93
29%
-72
- C1 -
1WE5
1
XYLS_ECOLI
A:
[154-664]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
---
V
R
---
N
G
-
Q
T
V
E
T
---
W
--------
N
R
---
D
-
G
G
T
--
S
T
EQA
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Q
F
S
V
E
S
E
---
Y
L
---
E
Y
F
V
I
D
G
-
P
-
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
-------
C
-
F
W
M
K
A
--
F
Q
W
C
D
F
E
W
D
P
L
T
-----------------
F
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
----
I
N
P
Y
I
G
Q
K
S
P
V
F
K
E
-----
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
S
-
L
W
Q
W
-
D
K
-
W
Q
P
---------------------
G
---
L
A
I
Y
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
-
L
V
--------
A
-
M
G
V
D
C
F
K
T
D
F
G
E
R
-
I
P
T
D
----------------------------------------------------------------------------
V
------------------------------------
Q
-----
W
----
F
D
----
G
--
S
D
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
--
V
L
K
D
T
VG
E
----
E
E
A
----
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
F
P
-
V
-
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
-
E
N
T
----------------------
A
-----
P
-
A
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
-
K
S
Y
-----
R
V
P
W
A
Y
-----
D
D
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
F
P
D
D
P
A
C
D
Y
L
D
R
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
-
A
G
D
V
Q
F
Y
L
P
E
G
-
R
W
T
H
L
W
H
N
-----
D
E
--
L
-
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.67
24%
-61
- C1 -
4B9Y
12
OL4AG_CELJU
A:
[62-696]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
E
A
A
I
E
V
L
Y
R
A
D
-
S
K
Q
L
P
-
S
F
A
L
--
A
Q
---
P
E
S
A
I
------
K
A
-----
Q
--------------
L
----------
T
E
T
-----
E
------
N
H
L
Q
F
S
G
---------
G
T
L
T
A
R
I
Q
K
R
P
F
-
A
I
S
Y
Y
--
R
--
D
S
E
L
L
L
A
E
E
S
------
G
F
Q
V
---
K
------
I
N
F
R
F
Y
L
S
P
G
E
K
I
L
G
G
G
Q
R
I
-
L
G
M
---
D
R
---
R
G
-
Q
R
F
P
L
---
Y
N
R
A
H
Y
G
--
Y
S
---
D
-
H
S
G
--
Q
M
---
Y
F
G
L
P
A
I
M
S
-----
S
K
----
Q
-----
Y
I
L
V
F
D
N
S
A
S
G
A
M
D
I
G
K
T
E
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
Q
L
E
A
K
-
S
G
R
S
---
A
Y
I
L
V
A
G
-
N
S
Y
P
S
L
I
E
N
-
F
T
Q
V
T
G
R
Q
P
L
P
P
R
W
A
L
G
S
F
A
S
R
F
---
G
Y
R
--
S
--
E
A
E
T
R
A
T
V
Q
K
Y
K
T
E
D
F
P
L
D
T
I
V
L
D
---------------
L
Y
W
F
G
K
---
D
I
K
G
H
M
G
N
L
D
W
D
K
E
N
F
P
T
------
P
L
D
M
M
A
D
F
K
Q
Q
G
V
K
T
V
L
I
T
E
P
F
V
L
T
S
S
K
R
W
D
D
A
V
K
A
K
A
---------
L
A
K
D
P
Q
-
G
Q
-
P
-
K
A
F
E
L
-
Y
F
G
---------------------
N
---
G
G
I
I
D
V
F
S
K
E
G
S
R
W
F
S
S
I
Y
K
D
-
L
S
--------
K
-
Q
G
V
A
G
W
W
G
D
L
G
E
P
E
M
H
P
E
---------------------------------
D
------------------------------------------
T
------------------------------------
Q
-----
H
----
A
I
----
G
--
D
-
A
D
--------------------------------
T
V
H
N
A
Y
G
H
R
W
A
E
M
L
Y
Q
Q
Q
L
D
Q
----
F
----
P
E
L
----
R
P
F
I
M
M
R
A
G
F
V
G
S
Q
R
Y
G
-
M
I
P
-
W
T
G
D
V
S
R
T
W
G
G
L
A
S
Q
V
E
L
A
L
Q
M
S
L
L
G
F
G
Y
I
H
S
D
L
G
G
F
A
D
G
E
----------------------
T
-----
L
D
K
E
M
Y
I
R
W
L
Q
Y
G
V
F
Q
P
V
Y
R
P
H
G
--------
Q
D
H
I
P
S
E
P
V
F
Q
--
D
E
E
T
K
A
I
L
R
P
L
V
K
L
R
Y
R
M
L
P
Y
I
Y
T
A
A
Y
Q
N
T
L
T
G
M
P
L
M
R
P
L
F
F
S
D
E
K
N
P
A
L
I
D
N
K
T
S
Y
F
W
G
D
S
L
L
V
T
P
I
T
Q
A
G
V
E
S
V
S
I
P
A
P
K
G
-
V
W
F
D
F
W
K
D
-----
T
R
Y
Q
T
-
D
-
G
A
P
L
-
T
L
P
T
D
L
H
T
I
P
V
L
V
K
A
G
-
A
F
M
P
-----
Y
V
P
A
---------
V
--------
S
T
T
E
D
Y
R
S
D
S
L
E
I
H
Y
Y
-
A
D
-----------------------------------------------------------------------------------------------------------------------------
22
HHSearch
72.59
23%
-55
- C1 -
3L4Y
10
MGA_HUMAN
A:
[76-777]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
F
G
S
N
V
D
N
V
L
L
T
A
--
E
Y
QTS
N
R
F
H
F
K
L
T
D
Q
T
N
N
-----
R
F-------------
E
----------
V
P
H
-----
E
H
V
Q
S
F
-
S
G
N
A
A
A
S
---------
L
T
Y
Q
V
E
I
S
R
Q
P
F
-
S
I
K
V
T
--
R
RS
N
N
R
V
L
F
D
S
S
I
G
----
P
L
L
F
-------
A
D
Q
F
L
Q
L
S
T
R
L
P
-
S
T
N
V
Y
G
L
G
E
H
V
-
H
Q
Q
---
Y
R
HDM
N
W
-
K
T
W
P
I
---
F
--
N
R
D
T
--
T
P
N--
G
-
N
G
T
--
N
L
---
Y
G
A
Q
T
F
F
L
C
LEDAS
G
L
----
S
-----
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
T
Y
R
T
I
-
G
G
I
L
---
D
F
Y
V
F
L
G
N
T
-
P
E
Q
V
V
Q
E
-
Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
---
E
Y
G
--
T
--
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I------
D
-
Y
M
D
----------------
E
R
R
D
F
T
Y
D
S
------
V
D
F
K
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
-
A
I
S
N
N
S
S
S
S
K
P
Y
G
--
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
-
G
V
T
P
L
I
-
G
E
V
-
W
P
G
---------------------
Q
---
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
-
F
H
--------
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
-
S
N
F
V
---------------------------------
D
GSVSGCSTNNLNNPPFTPRILDGYLFCKTLCMD---------
A
------------------------------------
V
-----
Q
----
H
W
----
G
---
K
Q
Y
--------------------------------
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
--
A
A
K
T
V
F
P
N
----
K
R
S
----
F
I
L
--
T
R
S
T
F
A
G
S
G
K
F
A
-
A
-
H
-
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
-
A
L
D
----------------------------
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
-
Q
G
---
Y
K
D
Q
D
P
A
S
F
G
A
D
---
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
-
V
W
Y
D
Y
E
T
G
-----
S
Q
--
V
-
R
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
-----
Q
Q
P
N
---------
T
T
-
T
L
A
S
------
R
K
N
P
L
G
L
I
I
A
L
D
-
E
N
K
E
-
A
K
G
E
L
F
W
D
D
G
-----
E
T
K
--------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.46
30%
-68
- C1 -
1XSK
3
XYLS_ECOLI
A:
[154-664]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
---
V
R
---
N
G
-
Q
T
V
E
T
---
W
--------
N
R
---
D
-
G
G
T
--
S
T
EQA
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Q
F
S
V
E
S
E
---
Y
L
---
E
Y
F
V
I
D
G
-
P
-
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
-
W
C
D
--------------------
F
E
W
D
P
L
T
F
P
------
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
----
I
N
P
Y
I
G
Q
K
S
P
V
F
K
E
L
Q
E
-----
K
G
Y
L
L
K
R
P
D
-
G
S
-
L
W
Q
W
-
D
K
-
W
Q
P
---------------------
G
---
L
A
I
Y
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
-
L
V
--------
A
-
M
G
V
D
C
F
K
T
D
F
G
E
R
-
I
P
T
D
----------------------------------------------------------------------------
V
------------------------------------
Q
-----
W
----
F
D
----
G
--
S
D
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
--
V
L
K
D
TVG
E
----
E
E
A
----
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
F
P
-
V
-
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
-
E
N
T
----------------------
A
-----
P
-
A
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
-
K
S
Y
-----
R
V
P
W
A
Y
-----
D
D
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
F
P
D
D
P
A
C
D
Y
L
D
R
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
-
A
G
D
V
Q
F
Y
L
P
E
G
-
R
W
T
H
L
W
H
N
-----
D
E
--
L
-
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.36
24%
-61
- C1 -
4BA0
9
OL4AG_CELJU
A:
[62-696]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
E
A
A
I
E
V
L
Y
R
A
D
-
S
K
Q
L
P
-
S
F
A
L
--
A
Q
---
P
E
S
A
I
------
K
A
-----
Q
--------------
L
----------
T
E
T
-----
E
------
N
H
L
Q
F
S
G
---------
G
T
L
T
A
R
I
Q
K
R
P
F
-
A
I
S
Y
Y
--
R
--
D
S
E
L
L
L
A
E
E
S
------
G
F
Q
V
N
--
K
------
I
N
F
R
F
Y
L
S
P
G
E
K
I
L
G
G
G
Q
R
I
-
L
G
M
---
D
R
---
R
G
-
Q
R
F
P
L
---
Y
N
R
A
H
Y
G
--
Y
S
---
D
-
H
S
G
--
Q
M
---
Y
F
G
L
P
A
I
M
S
-----
S
K
----
Q
-----
Y
I
L
V
F
D
N
S
A
S
G
A
M
D
I
G
K
T
E
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
Q
L
E
A
K
-
S
G
R
S
---
A
Y
I
L
V
A
G
-
N
S
Y
P
S
L
I
E
N
-
F
T
Q
V
T
G
R
Q
P
L
P
P
R
W
A
L
G
S
F
A
S
R
F
---
G
Y
R
--
S
--
E
A
E
T
R
A
T
V
Q
K
Y
K
T
E
D
F
P
L
D
T
I
V
L
D
---------------
L
Y
W
F
G
K
---
D
I
K
G
H
M
G
N
L
D
W
D
K
E
N
F
P
T
------
P
L
D
M
M
A
D
F
K
Q
Q
G
V
K
T
V
L
I
T
E
P
F
V
L
T
S
S
K
R
W
D
D
A
V
K
A
K
A
---------
L
A
K
D
P
Q
-
G
Q
-
P
-
K
A
F
E
L
-
Y
F
G
---------------------
N
---
G
G
I
I
D
V
F
S
K
E
G
S
R
W
F
S
S
I
Y
K
D
-
L
S
--------
K
-
Q
G
V
A
G
W
W
G
D
L
G
E
P
E
M
H
P
E
---------------------------------
D
------------------------------------------
T
------------------------------------
Q
-----
H
----
A
I
----
G
--
D
-
A
D
--------------------------------
T
V
H
N
A
Y
G
H
R
W
A
E
M
L
Y
Q
Q
Q
L
D
Q
----
F
----
P
E
L
----
R
P
F
I
M
M
R
A
G
F
V
G
S
Q
R
Y
G
-
M
I
P
-
W
T
G
D
V
S
R
T
W
G
G
L
A
S
Q
V
E
L
A
L
Q
M
S
L
L
G
F
G
Y
I
H
S
D
L
G
G
F
A
D
G
E
----------------------
T
-----
L
D
K
E
M
Y
I
R
W
L
Q
Y
G
V
F
Q
P
V
Y
R
P
H
G
--------
Q
D
H
I
P
S
E
P
V
F
Q
--
D
E
E
T
K
A
I
L
R
P
L
V
K
L
R
Y
R
M
L
P
Y
I
Y
T
A
A
Y
Q
N
T
L
T
G
M
P
L
M
R
P
L
F
F
S
D
E
K
N
P
A
L
I
D
N
K
T
S
Y
F
W
G
D
S
L
L
V
T
P
I
T
Q
A
G
V
E
S
V
S
I
P
A
P
K
G
-
V
W
F
D
F
W
K
D
-----
T
R
Y
Q
T
-
D
-
G
A
P
L
-
T
L
P
T
D
L
H
T
I
P
V
L
V
K
A
G
-
A
F
M
P
-----
Y
V
P
A
---------
V
--------
S
T
T
E
D
Y
R
S
D
S
L
E
I
H
Y
Y
-
A
D
-----------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.20
24%
-61
- C1 -
4B9Z
17
OL4AG_CELJU
A:
[62-696]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
E
A
A
I
E
V
L
Y
R
A
D
-
S
K
Q
L
P
-
S
F
A
L
--
A
Q
---
P
E
S
A
I
------
K
A
-----
Q
--------------
L
----------
T
E
T
-----
E
------
N
H
L
Q
F
S
G
---------
G
T
L
T
A
R
I
Q
K
R
P
F
-
A
I
S
Y
Y
--
R
--
D
S
E
L
L
L
A
E
E
S
------
G
F
Q
V
---
K
------
I
N
F
R
F
Y
L
S
P
G
E
K
I
L
G
G
G
Q
R
I
-
L
G
M
---
D
R
---
R
G
-
Q
R
F
P
L
---
Y
N
R
A
H
Y
G
--
Y
S
---
D
-
H
S
G
--
Q
M
---
Y
F
G
L
P
A
I
M
S
-----
S
K
----
Q
-----
Y
I
L
V
F
D
N
S
A
S
G
A
M
D
I
G
K
T
E
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
Q
L
E
A
K
-
S
G
R
S
---
A
Y
I
L
V
A
G
-
N
S
Y
P
S
L
I
E
N
-
F
T
Q
V
T
G
R
Q
P
L
P
P
R
W
A
L
G
S
F
A
S
R
F
---
G
Y
R
--
S
--
E
A
E
T
R
A
T
V
Q
K
Y
K
T
E
D
F
P
L
D
T
I
V
L
D
---------------
L
Y
W
F
G
K
---
D
I
K
G
H
M
G
N
L
D
W
D
K
E
N
F
P
T
------
P
L
D
M
M
A
D
F
K
Q
Q
G
V
K
T
V
L
I
T
E
P
F
V
L
T
S
S
K
R
W
D
D
A
V
K
A
K
A
---------
L
A
K
D
P
Q
-
G
Q
-
P
-
K
A
F
E
L
-
Y
F
G
---------------------
N
---
G
G
I
I
D
V
F
S
K
E
G
S
R
W
F
S
S
I
Y
K
D
-
L
S
--------
K
-
Q
G
V
A
G
W
W
G
D
L
G
E
P
E
M
H
P
E
---------------------------------
D
------------------------------------------
T
------------------------------------
Q
-----
H
----
A
I
----
G
--
D
-
A
D
--------------------------------
T
V
H
N
A
Y
G
H
R
W
A
E
M
L
Y
Q
Q
Q
L
D
Q
----
F
----
P
E
L
----
R
P
F
I
M
M
R
A
G
F
V
G
S
Q
R
Y
G
-
M
I
P
-
W
T
G
D
V
S
R
T
W
G
G
L
A
S
Q
V
E
L
A
L
Q
M
S
L
L
G
F
G
Y
I
H
S
D
L
G
G
F
A
D
G
E
----------------------
T
-----
L
D
K
E
M
Y
I
R
W
L
Q
Y
G
V
F
Q
P
V
Y
R
P
H
G
--------
Q
D
H
I
P
S
E
P
V
F
Q
--
D
E
E
T
K
A
I
L
R
P
L
V
K
L
R
Y
R
M
L
P
Y
I
Y
T
A
A
Y
Q
N
T
L
T
G
M
P
L
M
R
P
L
F
F
S
D
E
K
N
P
A
L
I
D
N
K
T
S
Y
F
W
G
D
S
L
L
V
T
P
I
T
Q
A
G
V
E
S
V
S
I
P
A
P
K
G
-
V
W
F
D
F
W
K
D
-----
T
R
Y
Q
T
-
D
-
G
A
P
L
-
T
L
P
T
D
L
H
T
I
P
V
L
V
K
A
G
-
A
F
M
P
-----
Y
V
P
A
---------
V
--------
S
T
T
E
D
Y
R
S
D
S
L
E
I
H
Y
Y
-
A
D
-----------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.86
30%
-64
- C1 -
1XSJ
2
XYLS_ECOLI
A:
[154-664]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
---
V
R
---
N
G
-
Q
T
V
E
T
---
W
--------
N
R
---
D
-
G
G
T
--
S
T
EQA
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Q
F
S
V
E
S
E
---
Y
L
---
E
Y
F
V
I
D
G
-
P
-
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
-
W
C
D
--------------------
F
E
W
D
P
L
T
F
P
------
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
----
I
N
P
Y
I
G
Q
K
S
P
V
F
K
E
L
Q
E
-----
K
G
Y
L
L
K
R
P
D
-
G
S
-
L
W
Q
W
-
D
K
-
W
Q
P
---------------------
G
---
L
A
I
Y
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
-
L
V
--------
A
-
M
G
V
D
C
F
K
T
D
F
G
E
R
-
I
P
T
D
----------------------------------------------------------------------------
V
------------------------------------
Q
-----
W
----
F
D
----
G
--
S
D
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
--
V
L
K
D
T
VG
E
----
E
E
A
----
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
F
P
-
V
-
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
-
E
N
T
----------------------
A
-----
P
-
A
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
-
K
S
Y
-----
R
V
P
W
A
Y
-----
D
D
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
F
P
D
D
P
A
C
D
Y
L
D
R
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
-
A
G
D
V
Q
F
Y
L
P
E
G
-
R
W
T
H
L
W
H
N
-----
D
E
--
L
-
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
71.55
21%
-48
- C1 -
2QMJ
14
MGA_HUMAN
A:
[7-870]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
E
L
E
R
I
N
C
I
P
D
Q
--
P
P
T
-
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
---------
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
-------
N
L
V
N
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
------------------
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
--
Q
T
---
N
N
-----
R
F
E
V
P
H
-----
E
--------------
H
----------
V
Q
S
-----
F
------
S
G
N
A
A
A
S
---------
L
T
Y
Q
V
E
I
S
R
Q
P
F
-
S
I
K
V
T
R
R
S
--
N
N
R
V
L
F
D
S
S
I
------
G
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
------
L
P
S
T
N
V
Y
G
L
G
E
H
V
-
H
Q
Q
---
Y
R
---
H
D
M
N
W
K
T
W
---
P
--
I
F
N
R
--
D
T
TPN
G
-
N
G
T
--
N
L
---
Y
G
A
Q
T
F
F
L
C
-----
L
E
----
D
ASG
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
I
T
Y
R
T
I
-
G
G
I
L
---
D
F
Y
V
F
L
G
N
T
-
P
E
Q
V
V
Q
E
-
Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
---
E
Y
G
--
T
--
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
---------------------
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
--
R
R
D
F
T
Y
D
S
------
V
D
F
K
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
-
A
I
S
N
N
S
S
S
S
K
P
Y
G
P
Y
D
R
G
--
S
D
M
K
I
W
V
N
S
S
D
-
G
V
-
T
P
L
I
G
E
V
-
W
P
G
---------------------
Q
---
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
-
F
H
N
-------
Q
-
V
E
F
D
G
I
W
I
D
M
N
E
V
-
S
N
F
V
---------------------------------
D
------------------------------------------
G
------------------------------------
S
-----
V
----
S
G
----
C
--
S
T
N
N
LNNPPFTPRILDGYLFCKTLCMD
A
V
Q
HWGKQY
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
--
A
A
K
----
T
V
F
PN
K
R
S
----
F
I
L
--
T
R
S
T
F
A
G
S
G
K
F
A
-
A
-
H
-
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
-
A
L
D
----------------------------
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
-
Q
G
---
Y
K
D
Q
D
P
A
S
F
G
A
D
S
---
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
-
V
W
Y
D
Y
E
T
G
-----
S
Q
--
V
R
W
-
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
QPNT
T
T
L
A
---------
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
---
T
K
D
T
V
A
N
K
V
Y
-----
L
L
C
-
E
F
S
V
T
Q
N
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
NNLAF
N
---------------------
E
I
K
I
L
G
TE
E
P
S
N
V
T
V
K
H
N
G
VPST
S
P
T
V
T
Y
D
SNLK
V
A
I
I
T
DIDLLLG
E
A
Y
T
V
E
W
A
H
3
PsiBlast_PDB
71.46
30%
-67
- C1 -
1XSI
2
XYLS_ECOLI
A:
[154-664]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
---
V
R
---
N
G
-
Q
T
V
E
T
---
W
--------
N
R
---
D
-
G
G
T
--
S
T
EQA
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Q
F
S
V
E
S
E
---
Y
L
---
E
Y
F
V
I
D
G
-
P
-
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
-
W
C
D
--------------------
F
E
W
D
P
L
T
F
P
------
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
----
I
N
P
Y
I
G
Q
K
S
P
V
F
K
E
L
Q
E
-----
K
G
Y
L
L
K
R
P
D
-
G
S
-
L
W
Q
W
-
D
K
-
W
Q
P
---------------------
G
---
L
A
I
Y
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
-
L
V
--------
A
-
M
G
V
D
C
F
K
T
D
F
G
E
R
-
I
P
T
D
----------------------------------------------------------------------------
V
------------------------------------
Q
-----
W
----
F
D
----
G
--
S
D
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
--
V
L
K
D
TVG
E
----
E
E
A
----
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
F
P
-
V
-
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
-
E
N
T
----------------------
A
-----
P
-
A
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
-
K
S
Y
-----
R
V
P
W
A
Y
-----
D
D
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
F
P
D
D
P
A
C
D
Y
L
D
R
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
-
A
G
D
V
Q
F
Y
L
P
E
G
-
R
W
T
H
L
W
H
N
-----
D
E
--
L
-
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
68.56
21%
-58
- C1 -
3TOP
1
MGA_HUMAN
A:
[81-807]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
P
V
N
P
L
R
L
D
V
--
T
Y
HKN
E
M
L
Q
F
K
I
Y
D
P
N
K
N
-----
R
Y-------------
E
----------
V
P
V
-----
P
L
N
I
PSM
P
S
S
T
P
E
G
---------
Q
L
Y
D
V
L
I
K
K
N
P
F
-
G
I
E
I
R
--
R
KS
T
G
T
I
I
W
D
S
Q
L
L
----
G
F
T
F
-------
S
D
M
F
I
R
I
S
T
R
L
P
-
S
K
Y
L
Y
G
F
G
E
T
E
-
H
R
S
---
Y
R
---
R
D
-
L
E
W
H
T
W
G
M
F
--
S
R
D
Q
--
P
P
---
G
-
Y
K
K
--
N
S
---
Y
G
V
H
P
Y
Y
M
G
-----
L
E
EDG
S
A
-----
H
G
V
L
L
L
N
S
N
A
M
D
V
T
F
Q
P
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
Y
R
T
T
-
G
G
V
L
---
D
F
Y
V
F
L
G
P
T
-
P
E
L
V
T
Q
Q
-
Y
T
E
L
I
G
R
P
V
M
V
P
Y
W
S
L
G
F
Q
L
C
R
Y
---
G
Y
Q
--
N
--
D
S
E
I
A
S
L
Y
D
E
M
V
A
A
Q
I
P
Y
D
V
Q
Y
S
D
I------
D
-
Y
M
E
----------------
R
Q
L
D
F
T
L
S
P
-------
K
F
A
G
F
P
A
L
I
N
R
M
K
A
D
G
M
R
V
I
L
I
L
D
P
-
A
I
S
G
N
E
T
Q
P
Y
P
A
----
F
T
R
G
V
E
D
D
V
F
I
K
Y
P
N
D
G
D
-
I
V
W
-
G
K
V
-
W
P
D
FPDVVVNGSLD
W
D
S
Q
V
E
L
YR
A
Y
---
V
A
F
P
D
F
F
R
N
S
T
A
K
W
W
K
R
E
I
E
E
-
L
Y
N
NPQNPER
S
-
L
K
F
D
G
M
W
I
D
M
N
E
P
-
S
S
F
V
---------------------------------
N
------------------------------------------
G
AVSPGCRDASLNHPPYMPHLESRDRGLSSKTLCME
S
Q
-----
Q
I
L
--
P
D
----
G
S
L
V
Q
H
Y
--------------------------------
N
V
H
N
L
Y
G
W
S
Q
T
R
P
T
Y
E
--
A
V
Q
E
V
T-
G
----
Q
R
G
----
V
V
I
--
T
R
S
T
F
P
S
S
G
R
W
A
-
G
-
H
-
W
L
G
D
N
T
A
A
W
D
Q
L
K
K
S
I
I
G
M
M
E
F
S
L
F
G
I
S
Y
T
G
A
D
I
C
G
F
-
F
Q
D
----------------------------
A
E
Y
E
M
C
V
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
T
-
I
G
---
T
R
R
Q
D
P
V
S
W
D
V
-----
A
F
V
N
I
S
R
T
V
L
Q
T
R
Y
T
L
L
P
Y
L
Y
T
L
M
H
K
A
H
T
E
G
V
T
V
V
R
P
L
L
H
E
F
V
S
D
Q
V
T
W
D
I
D
S
Q
F
L
L
G
P
A
F
L
V
S
P
V
L
E
R
N
A
R
N
V
T
A
Y
F
P
R
A
-
R
W
Y
D
Y
Y
T
G
-----
V
D
--
I
-
N
A
R
G
E
W
K
T
L
P
A
P
L
D
H
I
N
L
H
V
R
G
G
Y
I
L
P
W
-----
Q
E
P
A
---------
L
N
-
T
H
L
------
S
R
Q
K
F
M
G
F
K
I
A
L
D
-
D
E
GT-
A
G
G
W
L
F
W
D
D
G
-----
Q
S
I
--------------------------------------------------------------------------------------------------------
28
HHSearch
68.34
22%
-60
- C1 -
3NSX
3
?
A:
[40-657]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
A
F
T
Y
I
M
D
E
D
D
I
V
Y
G
L
G
E
S
N
-
R
G
I
---
N
K
---
R
G
-
Y
C
Y
I
S
---
N
--
C
T
D
D
--
P
I
HT-
E
-
D
K
R
--
S
L
---
Y
G
A
H
N
F
I
I
V
-----
S
G
K
T
--
T
-----
F
G
L
F
F
D
Y
P
S
K
L
T
F
D
I
G
Y
T
R
M
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
K
V
S
C
E
-
N
A
D
L
---
D
I
Y
V
I
E
G
E
N
-
A
Y
D
I
V
K
Q
-
F
R
R
V
I
G
R
S
Y
I
P
P
K
F
A
F
G
F
G
Q
S
R
W
---
G
Y
T
--
T
--
K
E
D
F
R
A
V
A
K
G
Y
R
E
N
H
I
P
I
D
M
I
Y
M
D
I------
D
-
Y
M
Q
----------------
D
F
K
D
F
T
V
N
E
------
K
N
F
P
D
F
P
E
F
V
K
E
M
K
D
Q
E
L
R
L
I
P
I
I
D
A
-
G
V
K
V
E
K
--
G
Y
E
V
----
Y
E
E
G
V
K
N
N
Y
F
C
K
R
E
D
-
G
S
-
D
F
V
A
-
A
V
-
W
P
G
---------------------
D
---
T
H
F
P
D
M
L
N
P
E
A
R
K
W
F
G
D
K
Y
R
F
-
L
I
--------
D
-
Q
G
I
E
G
F
W
N
D
M
N
E
P
-
A
I
F
Y
---------------------------------
S
S
E
G
L
A
E
A
K
E
F
A
G
E
F
A
K
DTEGKIH
P
W
A
M
Q
A
K
M
K
D
I
VNS
P
E
D
Y
K
R
------------------------------------
F
-----
Y
----
H
N
V
NG
K
K
--
I
R
H
D
--------------------------------
K
V
H
N
L
F
G
Y
N
M
T
R
A
A
G
E
--
A
F
E
R
I
DP
E
----
K
R
F
----
L
M
F
--
S
R
S
S
Y
I
G
M
H
R
Y
G
-
G
-
I
-
W
M
G
A
N
K
S
W
W
S
H
I
L
L
N
L
K
M
L
P
S
L
N
M
C
G
F
M
Y
T
G
A
D
L
G
G
F
-
G
D
D
----------------------------
T
T
R
D
L
L
L
R
F
L
A
L
G
V
F
T
P
L
M
R
D
H
A
A
-
E
G
---
T
R
E
Q
E
C
Y
Q
F
E
-------
N
I
E
D
F
R
S
V
I
N
A
R
Y
R
L
V
P
Y
L
Y
S
E
Y
M
K
A
A
L
N
D
D
M
Y
F
K
P
L
G
F
V
Y
P
D
D
K
M
A
I
R
V
E
D
Q
L
M
L
G
N
E
I
M
I
A
P
V
Y
E
Q
N
A
R
G
R
Y
V
Y
L
P
E
E
M
K
F
I
K
F
M
P
D
G
S
I
S
E
E
V
--
L
-
E
-
K
G
-
V
H
Y
V
D
V
A
L
N
E
V
P
L
F
I
R
S
G
K
C
I
P
V
-----
A
E
A
A
---------
E
C
V
-
K
D
I
------
D
T
E
N
M
Q
L
I
G
Y
E
G
------
S
S
Y
T
L
Y
E
D
D
G
-----
I
H
K
-
D
Y
D
K
---------------------------------------------------------------------------------------------------
25
HHSearch
68.33
20%
-53
- C1 -
3LPP
4
SUIS_HUMAN
A:
[104-805]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
F
G
N
D
I
N
S
V
L
F
T
T
--
Q
N
QTP
N
R
F
R
F
K
I
T
D
P
N
N
R
-----
R
Y-------------
E
----------
V
P
H
QY
V
K
E
F
------
T
G
P
T
V
S
D
---------
T
L
Y
D
V
K
V
A
Q
N
P
F
-
S
I
Q
V
I
--
R
KS
N
G
K
T
L
F
D
T
S
I
G
----
P
L
V
Y
-------
S
D
Q
Y
L
Q
I
S
A
R
L
P
-
S
D
Y
I
Y
G
I
G
E
Q
V
-
H
K
R
FRH
D
L
---
S
W
-
K
T
W
P
I
---
F
--
T
R
D
Q
--
L
P
---
G
D
N
N
N
--
N
L
---
Y
G
H
Q
T
F
F
M
C
I
EDTS
G
K
----
S
-----
F
G
V
F
L
M
N
S
N
A
M
E
I
F
I
Q
P
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
T
Y
R
V
T
-
G
G
I
L
---
D
F
Y
I
L
L
G
D
T
-
P
E
Q
V
V
Q
Q
-
Y
Q
Q
L
V
G
L
P
A
M
P
A
Y
W
N
L
G
F
Q
L
S
R
W
---
N
Y
K
--
S
--
L
D
V
V
K
E
V
V
R
R
N
R
E
A
G
I
P
F
D
T
Q
V
T
D
I------
D
-
Y
M
----------------
E
D
K
K
D
F
T
Y
D
Q
------
V
A
F
N
G
L
P
Q
F
V
Q
D
L
H
D
H
G
Q
K
Y
V
I
I
L
D
P
-
A
I
S
I
G
R
R
A
N
G
T
T
Y
A
-
T
Y
E
R
G
N
T
Q
H
V
W
I
N
E
S
D
-
G
S
T
P
I
I
-
G
E
V
-
W
P
G
---------------------
L
---
T
V
Y
P
D
F
T
N
P
N
C
I
D
W
W
A
N
E
C
S
I
-
F
H
Q
-------
E
-
V
Q
Y
D
G
L
W
I
D
M
N
E
V
-
S
S
F
I
QGSTKGCNVNKLNYPPFTPDILDKLMYSKTICM
D
------------------------------------------
A
------------------------------------
V
-----
Q
-----
N
----
W
--
G
K
Q
Y
--------------------------------
D
V
H
S
L
Y
G
Y
S
M
A
I
A
T
E
Q
--
A
V
Q
K
V
FP
N
----
K
R
S
----
F
I
L
--
T
R
S
T
F
A
G
S
G
R
H
A
-
A
-
H
-
W
L
G
D
N
T
A
S
W
E
Q
M
E
W
S
I
T
G
M
L
E
F
S
L
F
G
I
P
L
V
G
A
D
I
C
G
F
-
V
A
E
----------------------------
T
T
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
S
-
D
G
---
Y
E
H
Q
D
P
A
F
F
G
Q
N
---
S
L
L
V
K
S
S
R
Q
Y
L
T
I
R
Y
T
L
L
P
F
L
Y
T
L
F
Y
K
A
H
V
F
G
E
T
V
A
R
P
V
L
H
E
F
Y
E
D
T
N
S
W
I
E
D
T
E
F
L
W
G
P
A
L
L
I
T
P
V
L
K
Q
G
A
D
T
V
S
A
Y
I
P
D
A
-
I
W
Y
D
Y
E
S
G
-----
A
K
--
R
-
P
W
R
K
Q
R
V
D
M
Y
L
P
A
D
K
I
G
L
H
L
R
G
G
Y
I
I
P
I
-----
Q
E
P
D
---------
V
T
T
-
T
A
------
S
R
K
N
P
L
G
L
I
V
A
L
G
-
E
N
N
T
-
A
K
G
D
F
F
W
D
D
G
-----
E
T
K
--------------------------------------------------------------------------------------------------------
27
HHSearch
65.53
25%
-59
- C1 -
2G3M
-
AGLU_SULSO
A:
[53-633]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
K
S
L
D
L
K
E
H
I
I
G
L
G
E
K
A
-
F
E
L
---
D
R
---
K
R
-
K
R
Y
V
M
---
Y
--
N
V
D
A
--
G
A
YK-
K
-
Y
Q
D
--
P
L
---
Y
V
S
I
P
L
F
I
S
-----
V
K
DG
V
-
A
-----
T
G
Y
F
F
N
S
A
S
K
V
I
F
D
V
G
L
E
E
Y
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
--
V
I
V
T
I
P
-
E
D
S
V
---
E
F
Y
V
I
E
G
P
R
-
I
E
D
V
L
E
K
-
Y
T
E
L
T
G
K
P
F
L
P
P
M
W
A
F
G
Y
M
I
S
R
Y
---
S
Y
Y
--
P
--
Q
D
K
V
V
E
L
V
D
I
M
Q
K
E
G
F
R
V
A
G
V
F
L
D
-------
I
H
Y
M
----------------
D
S
Y
K
L
F
T
W
H
P
------
Y
R
F
P
E
P
K
K
L
I
D
E
L
H
K
R
N
V
K
L
I
T
I
V
D
H
-
G
I
R
V
D
Q
--
N
Y
S
P
------
F
L
S
G
M
G
K
F
C
E
I
E
S
-
G
E
-
L
F
V
-
G
K
M
-
W
P
G
---------------------
T
---
T
V
Y
P
D
F
F
R
E
D
T
R
E
W
W
A
G
L
I
S
E
-
W
L
--------
S
-
Q
G
V
D
G
I
W
L
D
M
N
E
P
-
T
D
F
S
---------------------------------
R
A
I
E
I
R
D
V
L
SSLP
V
Q
F
R
DDRLVTTFPDN---------------
V
------------------------------------
V
-----
H
Y
---
L
R
G
K
--
R
--
V
K
H
E
--------------------------------
K
V
R
N
A
Y
P
L
Y
E
A
M
A
T
F
K
--
G
F
R
T
S
H-
R
----
N
E
I
----
F
I
L
--
S
R
A
G
Y
A
G
I
Q
R
Y
A
-
F
-
I
-
W
T
G
D
N
T
P
S
W
D
D
L
K
L
Q
L
Q
L
V
L
G
L
S
I
S
G
V
P
F
V
G
C
D
I
G
G
F
-
Q
G
R
----------------------
N
FAEID
N
S
M
D
L
L
V
K
Y
Y
A
L
A
L
F
F
P
F
Y
R
S
H
K
A
-
T
D
---
G
I
D
T
E
P
V
F
L
P
D
-----
Y
Y
K
E
K
V
K
E
I
V
E
L
R
Y
K
F
L
P
Y
I
Y
S
L
A
L
E
A
S
E
K
G
H
P
V
I
R
P
L
F
Y
E
F
Q
D
D
D
D
M
Y
R
I
E
D
E
Y
M
V
G
K
Y
L
L
Y
A
P
I
V
S
K
E
E
-
S
R
L
V
T
L
P
R
G
-
K
W
Y
N
Y
W
N
G
-----
E
I
--
I
-
N
-
G
K
S
V
V
---
K
S
T
H
E
L
P
I
Y
L
R
E
G
S
I
I
P
L
-----
E
G
D
----------------------------
E
L
I
V
Y
---
G
E
---
T
S
F
K
R
Y
D
N
A
E
-----
I
T
S
--------------------------------------------------------------------------------------------------------