@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0198: (2016-03-13 )
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLNVDKVVTIVGHGAEKVQEHLAGKSEFVKQDEQLGTAHAVLQAKAELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDSDEVVAAYRMESFEESLGVNDRIALAEASKLMQRRINENHMRNGVTLVNPESTYIDIDVKIGQDTVIEPGVMLRGKTVIGDDCVVTSGSEIVNSVIGERVHVRTSSIFESKVGDDVQIGPYAHLRPESDIHDHVKIGNYVETKKAVVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDNVFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQDNKLGYAKHLNHSK
Atome Classification :
(51 SA)
....--.....10........20.---.......30........40........50........60-------.....-..-.70---.........80........90..-......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.-......230.......240.......250.......260.......270.......280.......290.......300.......310......-..320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.....---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSK
R
--
Y
A
V
V
L
AAGQGT
R
M
K
S
K
L
Y
---
K
V
L
HPVCG
K
P
M
V
E
H
V
V
D
Q
I
S
TL
N
V
D
K
V
V
T
I
VGH
G
A
E
K
V
Q
-------
E
H
LA
G
-
K
S
-
E
F
----
V
K
Q
D
E
QL
G
T
A
H
A
V
L
Q
A
K
A
E
LAGK-D
G
V
T
L
V
V
CGDTPLI
E
A
S
T
M
E
A
L
L
K
Y
H
H
E
KRAK
A
T
I
L
T
T
V
IEDPTGY
G
R
I
I
R
D
D
L
G
I
V
E
K
I
V
EHKDA
T
E
K
E
Q
R
I
S
EINTG
T
Y
CFD
N
K
A
L
F
E
A
L
E
NVSNDNVQGEYY
L
P
D
V
I
K
ILKDS
D
E
V
V
A
A
Y
R
M
E
S
F
E
E
-
S
LGVND
R
I
A
L
A
E
A
S
K
L
M
Q
R
RI
N
E
N
H
MRN
G
V
T
L
VNPES
T
Y
I
D
I
D
V
K
IGQDTVIEPG
V
M
L
RG
K
T
VIGDD
C
V
VTS
G
S
E
I
V
N
S
V
IGE
R
V
H
V
R
-
T
S
S
I
F
E
-
S
KVGDDVQIGPYAHLRPESDIHDHVKIG
N
Y
V
E
T
K
K
A
VVGEGTKL
P
H
F
I
Y
MGDAEIGKNVNVGC
G
S
I
A
V
NYDGKN
K
A
K
T
IIGD
N
V
F
VGCNS
N
L
I
A
P
V
KVG
D
R
A
F
I
AAGSTITKDV
P
E
D
A
L
G
I
ARAKQDNKLG
Y
A
K
HLNHSK---
6
PsiBlast_PDB
96.13
54%
-109
- C1 -
4AAW
2
GLMU_STRR6
A:
[4-454]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
E
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
---
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
-----
7
PsiBlast_PDB
96.07
54%
-110
- C1 -
4AC3
2
GLMU_STRR6
A:
[4-454]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
E
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
--
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
-----
2
PsiBlast_PDB
96.03
54%
-109
- C1 -
1HM8
2
GLMU_STRPN
A:
[13-463]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
-----
22
PsiBlast_CBE
95.50
54%
-108
- C1 -
1HM8
2
GLMU_STRPN
B:
[13-463]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
-----
23
PsiBlast_CBE
95.35
54%
-112
- C1 -
1HM0
2
GLMU_STRPN
B:
[13-456]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
------
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
------------
3
PsiBlast_PDB
94.38
54%
-112
- C1 -
1HM0
2
GLMU_STRPN
A:
[13-456]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
------
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
------------
4
PsiBlast_PDB
94.04
54%
-108
- C1 -
1G95
-
GLMU_STRPN
A:
[4-452]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
------
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
S
E
V
Q
I
E
A
N
V
T
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
I
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
N
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
-------
5
PsiBlast_PDB
93.96
54%
-107
- C1 -
1G97
3
GLMU_STRPN
A:
[4-447]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
S
E
V
Q
I
E
A
N
V
T
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
I
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
N
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
------------
21
PsiBlast_CBE
93.40
54%
-102
- C1 -
1HM9
6
GLMU_STRPN
B:
[13-463]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
-----
70
HHSearch
93.23
55%
-102
- C1 -
1HM9
6
GLMU_STRPN
A:
[11-461]
--
S
N
--
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
-------
1
PsiBlast_PDB
92.93
54%
-104
- C1 -
1HM9
6
GLMU_STRPN
A:
[13-463]
------
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
-----
92
Fugue
92.89
54%
-102
- C1 -
1HM9
6
GLMU_STRPN
A:
[11-468]
--
S
N
--
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
---
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
-------
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
-
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
KNQ
29
PsiBlast_CBE
89.09
41%
-107
- C1 -
4E1K
5
GLMU_HAEIN
A:
[4-451]
---
K
A
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
---
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
-------
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
N
I
-
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
E
N
--
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
-
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
---------
28
PsiBlast_CBE
89.02
41%
-106
- C1 -
4KNR
9
GLMU_HAEIN
A:
[4-451]
---
K
A
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
---
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
-------
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
N
I
-
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
E
N
--
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
-
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
---------
26
PsiBlast_CBE
88.82
41%
-106
- C1 -
4KPX
11
GLMU_HAEIN
A:
[4-451]
---
K
A
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
---
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
-------
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
N
I
-
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
E
N
--
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
-
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
---------
27
PsiBlast_CBE
88.80
41%
-105
- C1 -
4KNX
8
GLMU_HAEIN
A:
[4-451]
---
K
A
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
---
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
-------
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G