@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0199: (2016-03-13 )
MSNEYFDPKLKIFSLNSNRELAEEIAKEVGIELGKSSVTHFSDGEIQINIEESIRGCHVYVIQSTSNPVNQNLMELLIMIDALKRASAATINIVMPYYGYARQDRKARSREPITAKLVANLIETAGATRMITLDMHAPQIQGFFDIPIDHLNAVRLLSDYFSERHLGDDLVVVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIVGNVEGKVCIIIDDIIDTAGTITLAAKALREAGATKVYACCSHPVLSGPAMKRIEESPIEKLVVTNSIALPEEKWIDKMEQLSVAALLGEAIVRVHENASVSSLFE
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100......-.-110.......120.......130.......140.......150.----..-....160....-...170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280...---..-..290.......300.......310......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNEYFDP
K
L
K
I
F
SLNS
N
R
E
L
A
E
E
I
A
K
E
V
G
I
ELGKSSVTHFSD
G
E
I
Q
I
N
I
E
ESIRG
C
H
V
Y
V
IQSTSNP
V
N
Q
N
L
M
E
L
L
I
M
I
D
A
L
K
RAS
A
A
T
I
N
I
VMPYYGYARQDRKAR-S-REP
I
T
A
K
L
V
A
N
L
I
E
TAGA
T
R
M
I
T
L
DMHAPQI
Q
G
F
F
DI
P
I
D
H
L
N
A
----
V
R
-
L
L
S
D
Y
F
S
ERHL-GD
D
L
V
V
V
SPDHG
G
V
T
R
A
R
K
M
A
D
R
LKA
P
I
A
I
IDKRRPRP
N
V
A
E
V
M
N
I
V
GNVEG
K
V
C
I
I
I
D
D
IIDTA
G
T
I
T
L
A
A
K
A
L
R
EAGA
T
K
V
Y
A
CCSHPVLS
G
P
A
M
K
R
I
E
ESPI
E
K
L
V
VTNSIAL
P
E
E
---
K
W
-
I
D
K
M
E
Q
L
S
V
A
A
L
L
G
E
A
I
V
R
VHENA
S
V
S
S
LFE
67
Fugue
97.77
76%
-156
- C8 -
1DKU
3
KPRS_BACSU
A:
[9-316]
--------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
----
V
P
-
I
L
G
E
Y
F
E
G
K
N
L
--
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
K
--------
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
21
PsiBlast_CBE
97.54
76%
-159
- C8 -
1DKU
3
KPRS_BACSU
B:
[9-316]
--------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
----
V
P
-
I
L
G
E
Y
F
E
G
K
N
L
--
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
-------
K
-
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
1
PsiBlast_PDB
97.44
76%
-156
- C8 -
1DKU
3
KPRS_BACSU
A:
[9-316]
--------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
----
V
P
-
I
L
G
E
Y
F
E
G
K
N
L
--
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
-------
K
-
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
48
HHSearch
96.87
77%
-154
- C8 -
1DKU
3
KPRS_BACSU
A:
[9-316]
--------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
----
V
P
-
I
L
G
E
Y
F
E
G
K
-
N
-
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
-------
K
-
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
22
PsiBlast_CBE
96.26
76%
-155
- C8 -
1DKR
3
KPRS_BACSU
B:
[2-316]
-
S
N
Q
Y
G
D
K
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
----
V
P
-
I
L
G
E
Y
F
E
G
K
N
L
--
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
P
E
E
---
K
K
-
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
23
PsiBlast_CBE
87.09
54%
-149
- C8 -
3DAH
5
?
C:
[8-313]
---------
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
-
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
----
T
P
I
L
L
G
D
L
R
K
Q
N
Y
---
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
I
D
K
R
R
-------
V
M
N
I
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
---
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
----
49
HHSearch
86.42
54%
-142
- C8 -
3DAH
4
?
A:
[6-315]
-------
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
-
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
----
T
P
-
I
L
L
G
D
L
R
K
Q
-
N
-
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
--------------------
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
--
L
A
-
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
--
47
HHSearch
85.83
46%
-148
* C8 *
3S5J
3
PRPS1_HUMAN
B:
[3-314]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
----
E
P
-
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M--
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
S
24
PsiBlast_CBE
85.10
54%
-145
- C8 -
3DAH
7
?
B:
[8-316]
---------
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
-
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
----
T
P
I
L
L
G
D
L
R
K
Q
N
Y
---
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
-----------------
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
---
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
F
-
5
PsiBlast_PDB
84.49
46%
-151
- C8 -
4LYG
2
PRPS1_HUMAN
A:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
T
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
D
K
M
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
9
PsiBlast_PDB
84.34
46%
-151
- C8 -
3EFH
4
PRPS1_HUMAN
A:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
K
-------
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
D
K
M
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
27
PsiBlast_CBE
84.28
46%
-153
- C8 -
4LYG
3
PRPS1_HUMAN
B:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
T
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
K
-----
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
D
K
M
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
8
PsiBlast_PDB
84.21
46%
-149
- C8 -
2HCR
8
PRPS1_HUMAN
A:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
D
K
M
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
35
PsiBlast_CBE
84.20
46%
-153
- C8 -
4M0P
3
PRPS1_HUMAN
B:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
T
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
EPAV
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
DKM
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
2
PsiBlast_PDB
84.19
54%
-144
- C8 -
3DAH
4
?
A:
[8-315]
---------
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
-
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
----
T
P
I
L
L
G
D
L
R
K
Q
N
Y
---
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
--------------------
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
---
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
--
10
PsiBlast_PDB
83.64
46%
-150
- C8 -
3S5J
3
PRPS1_HUMAN
B:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
EPAV
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
DKM
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
28
PsiBlast_CBE
83.61
46%
-150
- C8 -
4LZN
3
PRPS1_HUMAN
A:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
N
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
D
K
M
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
26
PsiBlast_CBE
83.56
46%
-151
- C8 -
4LZO
3
PRPS1_HUMAN
B:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
T
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
EPAV
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
DKM
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
11
PsiBlast_PDB
83.54
46%
-150
- C8 -
2H08
5
PRPS1_HUMAN
A:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
M
A
E
P
A
V
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
D
K
M
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
6
PsiBlast_PDB
83.52
46%
-152
- C8 -
4LZN
3
PRPS1_HUMAN
B:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
N
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
EPAV
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
DKM
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
31
PsiBlast_CBE
83.40
46%
-149
- C8 -
2HCR
8
PRPS1_HUMAN
B:
[3-313]
--------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
-
W
I
R
E
N
I
S
E
W
R
----
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
Q
E
D
K
M
K
H
-
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-