@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0210: (2016-03-13 )
MKDHQKIILVGDGAVGSSYAFACVNLSIGQEFGIIDIDKDRTIGDAMDLSHAVPFSTPKKIYSANYSDCHDADLVVVTAGTAQKPGETRLDLVNRNIKIMKGIVDEVMASGFDGIFLIASNPVDILTYATWKFSGLPKERVIGSGTSLDTARFRMSIADYLKVDARNVHGYILGEHGDTEFPAWSHTTVGGLPITEWISEDEQGAMDTIFVSVRDAAYEIINKKGATFYGVAAALARITKAILNNENAILPLSVYLDGHYGMNDIYIGAPAVVNRQGVRHIVEMNLNDKEKEQMKNSADTLKKVLDDAMKQID
Atome Classification :
(57 SA)
....-.....10........20........30........40........50.....-.-..-60..-.-....-.70........80........90........100.......110.......120.......130.......140.......150.......160......-.170.......180.......190.....-------.----.---200----.---..--....-----.210----.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKD
H
-
Q
K
I
I
L
V
GDGAVGS
S
Y
A
F
A
C
V
N
LSIG
Q
E
FG
I
I
D
IDKDRTIG
D
A
MDLSHAVPFS-T-
P
K
-
K
I
YS-A-NYSD-CHDA
D
L
V
V
V
TAGTAQKPGE
T
R
L
D
L
VNR
N
I
K
I
M
K
G
I
V
D
E
V
M
A
SGF
D
G
I
F
L
IASNP
V
D
I
L
T
Y
A
T
W
KFSGL
P
K
E
R
VIGSGTSL
D
T
A
R
F
R
M
S
I
A
D
Y
L
KVDARN
V
-
H
G
Y
I
L
GEHGDTEFPAWSHTTVGGL
P
I
T
E
W
-------I----S---ED-----E---QG--AM
D
T
-----
I
F
V
S
----
V
R
D
A
A
Y
E
I
I
NKKGA
T
F
Y
G
V
A
A
A
L
A
R
I
T
K
A
I
LNNEN
A
I
L
P
L
S
V
Y
L
DGHYGM
N
D
I
Y
IGA
P
A
VV
N
R
Q
G
V
R
H
I
V
EMNLN
D
K
E
K
E
Q
M
K
N
S
A
D
T
L
K
K
V
L
D
D
A
M
K
QID
32
PsiBlast_CBE
95.55
67%
-122
- C6 -
2ZQY
4
LDH_LACCA
C:
[10-321]
-----
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
A
K
N
D
26
PsiBlast_CBE
95.34
67%
-122
- C6 -
2ZQZ
3
LDH_LACCA
F:
[7-318]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
A
---
36
PsiBlast_CBE
95.20
66%
-121
- C6 -
3VPF
3
LDH_LACCA
D:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
39
PsiBlast_CBE
94.88
66%
-123
- C6 -
3VKU
3
LDH_LACCA
F:
[7-318]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
A
---
40
PsiBlast_CBE
94.86
66%
-122
- C6 -
3VKU
3
LDH_LACCA
E:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
27
PsiBlast_CBE
94.58
67%
-120
- C6 -
2ZQZ
3
LDH_LACCA
E:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
23
PsiBlast_CBE
94.55
67%
-125
- C6 -
3VKV
2
LDH_LACCA
D:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
-----
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
22
PsiBlast_CBE
94.47
67%
-122
- C6 -
3VKV
2
LDH_LACCA
E:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
28
PsiBlast_CBE
94.30
67%
-127
- C6 -
2ZQZ
3
LDH_LACCA
D:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
-----
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
25
PsiBlast_CBE
93.92
67%
-124
- C6 -
3VKV
2
LDH_LACCA
B:
[7-318]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
A
---
31
PsiBlast_CBE
93.82
67%
-126
- C6 -
2ZQY
4
LDH_LACCA
D:
[10-317]
-----
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
---
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
21
PsiBlast_CBE
93.80
67%
-122
- C6 -
3VKV
2
LDH_LACCA
F:
[7-318]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
A
---
1
PsiBlast_PDB
93.78
67%
-126
- C6 -
2ZQY
4
LDH_LACCA
A:
[10-317]
-----
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
---
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
33
PsiBlast_CBE
93.76
67%
-125
- C6 -
2ZQY
4
LDH_LACCA
B:
[10-317]
-----
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
35
PsiBlast_CBE
93.73
66%
-123
- C6 -
3VPF
3
LDH_LACCA
E:
[7-318]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
AHP
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
A
---
43
PsiBlast_CBE
93.59
66%
-123
- C6 -
3VKU
2
LDH_LACCA
B:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
30
PsiBlast_CBE
93.40
67%
-121
- C6 -
2ZQZ
2
LDH_LACCA
B:
[7-318]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
A
---
2
PsiBlast_PDB
93.40
67%
-124
- C6 -
2ZQZ
2
LDH_LACCA
A:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
-----
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
37
PsiBlast_CBE
93.31
66%
-119
- C6 -
3VPF
3
LDH_LACCA
C:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
3
PsiBlast_PDB
92.95
67%
-128
- C6 -
3VKV
1
LDH_LACCA
A:
[7-317]
-
K
D
H
-
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
-
P
K
-
K
I
Y
S
-
A
-
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
-----
T
R
L
D
L
V
N
K
N
L
K
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
-
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
-------
V
----
K
A
H
P
E
I
-----
K
---
E
D
--
K
L
V
K
-----
M
F
E
D
----
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
L
T
D
A
F
----
53
PsiBlast_CBE
91.59
58%
-124
- C6 -
1EZ4
1
LDH_LACPE
B:
[2-316]
M
P
N
H
-
Q
K
V
V
L
V
G
D
G
A
V
G
S
S
Y
A
F
A
M
A
Q
Q
G
I
A
E
E
F
V
I
V
D
V
V
K
D
R
T
K
G
D
A
L
D
L
E
D
A
Q
A
F
T
-
A
-
P
K
-
K
I
Y
S
-
G
-
E
Y
S
D
-
C
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
S
R
L
D
L
V
N
K
N
L
N
I
L
S
S
I
V
K
P
V
V
D
S
G
F
D
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
F
P
K
E
R
V
I
G
S
G
T
S
L
D
S
S
R
L
R
V
A
L
G
K
Q
F
N
V
D
P
R
S
V
-
D
A
Y
I
M
G
E
H
G
D
S
E
F
A
A
Y
S
T
A
T
I
G
T
R
P
V
R
D
V
-------
A
----
K
----------
E
---
Q
G
--
V
S
D
D
-----
D
L
A
K
L
E
D
G
V
R
N
K
A
Y
D
I
I
N
L
K
G
A
T
F
Y
G
I
G
T
A
L
M
R
I
S
K
A
I
L
R
D
E
N
A
V
L
P
V
G
A
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
I
I
G
G
T
G
L
K
Q
I
I
E
S
P
L
S
A
D
E
L
K
K
M
Q
D
S
A
A
T
L
K
K
V
L
N
D
G
L
A
E
L
E
51
PsiBlast_CBE
91.21
58%
-124
- C6 -
1EZ4
1
LDH_LACPE
D:
[2-316]
M
P
N
H
-
Q
K
V
V
L
V
G
D
G
A
V
G
S
S
Y
A
F
A
M
A
Q
Q
G
I
A
E
E
F
V
I
V
D
V
V
K
D
R
T
K
G
D
A
L
D
L
E
D
A
Q
A
F
T
-
A
-
P
K
-
K
I
Y
S
-
G
-
E
Y
S
D
-
C
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
P
G
E
S
R
L
D
L
V
N
K
N
L
N
I
L
S
S
I
V
K
P
V
V
D
S
G
F
D
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
F
P
K
E
R
V
I
G
S
G
T
S
L
D
S
S
R
L
R
V
A
L
G
K
Q
F
N
V
D
P
R
S
V
-
D
A
Y
I
M
G
E
H
G
D
S
E
F
A
A
Y
S
T
A
T
I
G
T
R
P
V
R
D
V
-------
A
----
K
----------
E
---
Q
G
--
V
S
D
D
-----
D
L
A
K
LEDG
V
R
N
K
A
Y
D
I
I
N
L
K
G
A
T
F
Y
G
I
G
T
A
L
M
R
I
S
K
A
I
L
R
D
E
N
A
V
L
P
V
G
A
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
I
I
G
G
T
G
L
K
Q
I
I
E
S
P
L
S
A
D
E
L
K
K
M
Q
D
S
A
A
T
L
K
K
V
L
N
D
G
L
A
E
L
E
8
PsiBlast_PDB
90.51
58%
-129
- C6 -
1EZ4
1
LDH_LACPE
A:
[2-316]
M
P
N
H
-
Q
K
V
V
L
V
G
D
G
A
V
G
S
S
Y
A
F
A
M
A
Q
Q
G
I
A
E
E
F
V
I
V
D
V
V
K
D
R
T
K
G
D
A
L
D
L
E
D
A
Q
A
F
T
-
A
-
P
K
-
K
I
Y
S
-
G
-
E
Y
S
D
-
C
K
D
A
D
L
V
V
I
T
A
G
A
----------
L
V
N
K
N
L
N
I
L
S
S
I
V
K
P
V
V
D
S
G
F
D
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
F
P
K
E
R
V
I
G
S
G
T
S
L
D
S
S
R
L
R
V
A
L
G
K
Q
F
N
V
D
P
R
S
V
-
D
A
Y
I
M
G
E
H
G
D
S
E
F
A
A
Y
S
T
A
T
I
G
T
R
P
V
R
D
V
-------
A
----
K
----------
E
---
Q
G
--
V
S
D
D
-----
D
L
A
K
L
E
D
G
V
R
N
K
A
Y
D
I
I
N
L
K
G
A
T
F
Y
G
I
G
T
A
L
M
R
I
S
K
A
I
L
R
D
E
N
A
V
L
P
V
G
A
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
I
I
G
G
T
G
L
K
Q
I
I
E
S
P
L
S
A
D
E
L
K
K
M
Q
D
S
A
A
T
L
K
K
V
L
N
D
G
L
A
E
L
E
110
HHSearch
90.47
58%
-128
- C6 -
1EZ4
1
LDH_LACPE
A:
[2-315]
M
P
N
H
-
Q
K
V
V
L
V
G
D
G
A
V
G
S
S
Y
A
F
A
M
A
Q
Q
G
I
A
E
E
F
V
I
V
D
V
V
K
D
R
T
K
G
D
A
L
D
L
E
D
A
Q
A
F
T
-
A
-
P
K
-
K
I
Y
S
-
G
-
E
Y
S
D
-
C
K
D
A
D
L
V
V
I
T
A
G
A
----------
L
V
N
K
N
L
N
I
L
S
S
I
V
K
P
V
V
D
S
G
F
D
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
F
P
K
E
R
V
I
G
S
G
T
S
L
D
S
S
R
L
R
V
A
L
G
K
Q
F
N
V
D
P
R
S
V
-
D
A
Y
I
M
G
E
H
G
D
S
E
F
A
A
Y
S
T
A
T
I
G
T
R
P
V
R
D
V
-------
A
----
K
---
E
Q
GV---
S
---
D
D
--
D
L
A
K
-----
L
E
D
G
----
V
R
N
K
A
Y
D
I
I
N
L
K
G
A
T
F
Y
G
I
G
T
A
L
M
R
I
S
K
A
I
L
R
D
E
N
A
V
L
P
V
G
A
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
I
I
G
G
T
G
L
K
Q
I
I
E
S
P
L
S
A
D
E
L
K
K
M
Q
D
S
A
A
T
L
K
K
V
L
N
D
G
L
A
E
L
-
54
PsiBlast_CBE
90.42
59%
-125
- C6 -
3PQF
1
LDH_BACSU
D:
[3-310]
--
K
H
V
N
K
V
A
L
I
G
A
G
F
V
G
S
S
Y
A
F
A
L
I
N
Q
G
I
T
D
E
L
V
V
I
D
V
N
K
E
K
A
M
G
D
V
M
D
L
N
H
G
K
A
F
A
P
Q
-
P
V
-
K
T
S
Y
-
G
-
T
Y
E
D
-
C
K
D
A
D
I
V
C
I
C
A
G
A
N
Q
K
P
G
E
T
R
L
E
L
V
E
K
N
L
K
I
F
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
T
L
D
S
A
R
F
R
F
M
L
S
E
Y
F
G
A
A
P
Q
N
V
-
C
A
H
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
V
G
G
V
P
V
S
E
L
-------
V
----
E
---
K
N
-----
D
AYK
Q
E
--
E
L
D
Q
-----
I
V
D
D
----
V
K
N
A
A
Y
H
I
I
E
K
K
G
A
T
Y
Y
G
V
A
M
S
L
A
R
I
T
K
A
I
L
H
N
E
N
S
I
L
T
V
S
T
Y
L
D
G
Q
Y
G
A
D
D
V
Y
I
G
V
P
A
V
V
N
R
G
G
I
A
G
I
T
E
L
N
L
N
E
K
E
K
E
Q
F
L
H
S
A
G
V
L
K
N
I
L
--------
13
PsiBlast_PDB
90.32
58%
-124
- C6 -
3H3J
4
LDH1_STAAC
A:
[8-313]
------
K
V
V
L
I
G
N
G
A
V
G
S
S
Y
A
F
S
L
V
N
Q
S
I
V
D
E
L
V
I
I
D
L
D
T
E
K
V
R
G
D
V
M
D
L
K
H
A
T
P
Y
S
P
T
-
T
V
-
R
V
K
A
-
G
-
E
Y
S
D
-
C
H
D
A
D
L
V
V
I
C
A
G
A
R
Q
K
P
G
E
T
R
L
D
L
V
S
K
N
L
K
I
F
K
S
I
V
G
E
V
M
A
S
K
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
A
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
I
L
D
S
A
R
F
R
L
L
L
S
E
A
F
D
V
A
P
R
S
V
-
D
A
Q
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
I
A
G
Q
P
L
K
T
L
-------
L
----
E
---
Q
R
-----
P
---
E
G
K
A
Q
I
E
Q
-----
I
F
V
Q
----
T
R
D
A
A
Y
D
I
I
Q
A
K
G
A
T
Y
Y
G
V
A
M
G
L
A
R
I
T
E
A
I
F
R
N
E
D
A
V
L
T
V
S
A
L
L
E
G
E
Y
E
E
E
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
N
V
V
E
I
P
L
N
D
E
E
Q
S
K
F
A
H
S
A
K
T
L
K
D
I
M
A
E
A
-----
52
PsiBlast_CBE
90.19
58%
-128
- C6 -
1EZ4
1
LDH_LACPE
C:
[2-316]
M
P
N
H
-
Q
K
V
V
L
V
G
D
G
A
V
G
S
S
Y
A
F
A
M
A
Q
Q
G
I
A
E
E
F
V
I
V
D
V
V
K
D
R
T
K
G
D
A
L
D
L
E
D
A
Q
A
F
T
-
A
-
P
K
-
K
I
Y
S
-
G
-
E
Y
S
D
-
C
K
D
A
D
L
V
V
I
T
A
G
A
----------
L
V
N
K
N
L
N
I
L
S
S
I
V
K
P
V
V
D
S
G
F
D
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
F
P
K
E
R
V
I
G
S
G
T
S
L
D
S
S
R
L
R
V
A
L
G
K
Q
F
N
V
D
P
R
S
V
-
D
A
Y
I
M
G
E
H
G
D
S
E
F
A
A
Y
S
T
A
T
I
G
T
R
P
V
R
D
V
-------
A
----
K
----------
E
---
Q
G
--
V
S
D
D
-----
D
L
A
K
LEDG
V
R
N
K
A
Y
D
I
I
N
L
K
G
A
T
F
Y
G
I
G
T
A
L
M
R
I
S
K
A
I
L
R
D
E
N
A
V
L
P
V
G
A
Y
M
D
G
Q
Y
G
L
N
D
I
Y
I
G
T
P
A
I
I
G
G
T
G
L
K
Q
I
I
E
S
P
L
S
A
D
E
L
K
K
M
Q
D
S
A
A
T
L
K
K
V
L
N
D
G
L
A
E
L
E
12
PsiBlast_PDB
89.75
58%
-127
- C6 -
3D4P
2
LDH1_STAAC
A:
[8-312]
------
K
V
V
L
I
G
N
G
A
V
G
S
S
Y
A
F
S
L
V
N
Q
S
I
V
D
E
L
V
I
I
D
L
D
T
E
K
V
R
G
D
V
M
D
L
K
H
A
T
P
Y
S
P
T
-
T
V
-
R
V
K
A
-
G
-
E
Y
S
D
-
C
H
D
A
D
L
V
V
I
C
A
G
A
A
Q
K
P
--
T
R
L
D
L
V
S
K
N
L
K
I
F
K
S
I
V
G
E
V
M
A
S
K
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
A
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
I
L
D
S
A
R
F
R
L
L
L
S
E
A
F
D
V
A
P
R
S
V
-
D
A
Q
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
I
A
G
Q
P
L
K
T
L
-------
L
----
E
---
Q
R
-----
P
---
E
G
K
A
Q
I
E
Q
-----
I
F
V
Q
----
T
R
D
A
A
Y
D
I
I
Q
A
K
G
A
T
Y
Y
G
V
A
M
G
L
A
R
I
T
E
A
I
F
R
N
E
D
A
V
L
T
V
S
A
L
L
E
G
E
Y
E
E
E
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
N
V
V
E
I
P
L
N
D
E
E
Q
S
K
F
A
H
S
A
K
T
L
K
D
I
M
A
E
------
57
PsiBlast_CBE
89.60
58%
-124
- C6 -
3H3J
4
LDH1_STAAC
B:
[8-313]
------
K
V
V
L
I
G
N
G
A
V
G
S
S
Y
A
F
S
L
V
N
Q
S
I
V
D
E
L
V
I
I
D
L
D
T
E
K
V
R
G
D
V
M
D
L
K
H
A
T
P
Y
S
P
T
-
T
V
-
R
V
K
A
-
G
-
E
Y
S
D
-
C
H
D
A
D
L
V
V
I
C
A
G
A
R
Q
K
P
G
E
T
R
L
D
L
V
S
K
N
L
K
I
F
K
S
I
V
G
E
V
M
A
S
K
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
A
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
I
L
D
S
A
R
F
R
L
L
L
S
E
A
F
D
V
A
P
R
S
V
-
D
A
Q
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
I
A
G
Q
P
L
K
T
L
-------
L
----
E
---
Q
R
-----
P
---
E
G
KA
Q
I
E
Q
-----
I
F
V
Q
----
T
R
D
A
A
Y
D
I
I
Q
A
K
G
A
T
Y
Y
G
V
A
M
G
L
A
R
I
T
E
A
I
F
R
N
E
D
A
V
L
T
V
S
A
L
L
E
G
E
Y
E
E
E
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
N
V
V
E
I
P
L
N
D
E
E
Q
S
K
F
A
H
S
A
K
T
L
K
D
I
M
A
E
A
-----
56
PsiBlast_CBE
88.89
58%
-124
- C6 -
3D4P
2
LDH1_STAAC
B:
[8-313]
------
K
V
V
L
I
G
N
G
A
V
G
S
S
Y
A
F
S
L
V
N
Q
S
I
V
D
E
L
V
I
I
D
L
D
T
E
K
V
R
G
D
V
M
D
L
K
H
A
T
P
Y
S
P
T
-
T
V
-
R
V
K
A
-
G
-
E
Y
S
D
-
C
H
D
A
D
L
V
V
I
C
A
G
A
A
Q
K
P
G
E
T
R
L
D
L
V
S
K
N
L
K
I
F
K
S
I
V
G
E
V
M
A
S
K
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
A
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
I
L
D
S
A
R
F
R
L
L
L
S
E
A
F
D
V
A
P
R
S
V
-
D
A
Q
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
I
A
G
Q
P
L
K
T
L
-------
L
----
E
---
Q
R
-----
P
---
E
G
K
A
Q
I
E
Q
-----
I
F
V
Q
----
T
R
D
A
A
Y
D
I
I
Q
A
K
G
A
T
Y
Y
G
V
A
M
G
L
A
R
I
T
E
A
I
F
R
N
E
D
A
V
L
T
V
S
A
L
L
E
G
E
Y
E
E
E
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
N
V
V
E
I
P
L
N
D
E
E
Q
S
K
F
A
H
S
A
K
T
L
K
D
I
M
A
E
A
-----
55
PsiBlast_CBE
88.83
59%
-124
- C6 -
3PQF
1
LDH_BACSU
C:
[3-310]
--
K
H
V
N
K
V
A
L
I
G
A
G
F
V
G
S
S
Y
A
F
A
L
I
N
Q
G
I
T
D
E
L
V
V
I
D
V
N
K
E
K
A
M
G
D
V
M
D
L
N
H
G
K
A
F
A
P
Q
-
P
V
-
K
T
S
Y
-
G
-
T
Y
E
D
-
C
K
D
A
D
I
V
C
I
C
A
G
A
N
Q
K
P
G
E
T
R
L
E
L
V
E
K
N
L
K
I
F
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
T
L
D
S
A
R
F
R
F
M
L
S
E
Y
F
G
A
A
P
Q
N
V
-
C
A
H
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
V
G
G
V
P
V
S
E
L
-------
V
----
E
---
K
N
-----
D
AYK
Q
E
--
E
L
D
Q
-----
I
V
D
D
----
V
K
N
A
A
Y
H
I
I
E
K
K
G
A
T
Y
Y
G
V
A
M
S
L
A
R
I
T
K
A
I
L
H
N
E
N
S
I
L
T
V
S
T
Y
L
D
G
Q
Y
G
A
D
D
V
Y
I
G
V
P
A
V
V
N
R
G
G
I
A
G
I
T
E
L
N
L
N
E
K
E
K
E
Q
F
L
H
S
A
G
V
L
K
N
I
L
--------
17
PsiBlast_PDB
88.82
56%
-128
- C6 -
4M1Q
5
?
A:
[29-331]
------
R
V
V
I
I
G
T
G
A
V
G
S
S
Y
A
F
S
M
I
N
Q
N
V
T
D
E
M
V
L
I
D
L
D
K
R
K
T
E
G
D
A
M
D
L
N
H
G
I
P
F
G
-
A
-
P
T
-
K
V
W
A
-
G
-
D
Y
G
D
-
C
K
S
A
D
I
V
V
I
T
A
G
A
A
Q
K
P
G
E
T
R
L
D
L
V
E
K
N
A
N
I
F
K
G
I
V
D
Q
V
M
G
S
G
F
N
G
I
F
I
I
A
T
N
P
V
D
V
L
A
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
I
L
D
T
A
R
F
R
F
L
L
S
E
Y
F
D
I
D
V
R
N
I
-
H
G
Y
I
M
G
E
H
G
D
T
E
L
P
V
W
S
Q
T
R
I
G
S
E
P
I
S
R
Y
-------
M
D
K
YK
P
---
D
G
-----
S
---
N
K
--
D
L
D
E
-----
I
F
V
N
----
V
R
D
A
A
Y
H
I
I
E
R
K
G
A
T
H
Y
A
I
A
M
G
L
A
R
L
T
K
A
I
L
R
N
E
Q
S
I
L
T
V
S
T
L
M
E
G
E
Y
D
L
D
D
V
Y
I
G
V
P
A
I
V
S
Q
K
G
V
E
R
A
I
E
I
D
L
N
D
E
E
M
K
K
L
H
H
S
S
N
T
L
K
D
V
---------
60
PsiBlast_CBE
85.64
57%
-125
- C6 -
2LDB
5
LDH_GEOSE
B:
[8-317]
------
R
V
V
V
I
G
A
G
F
V
G
A
S
Y
V
F
A
L
M
N
Q
G
I
A
D
E
I
V
L
I
D
A
N
E
S
K
A
I
G
D
A
M
D
F
N
H
G
K
V
F
A
P
K
-
P
V
-
D
I
W
----
D
Y
D
D
-
C
R
D
A
D
L
V
V
I
C
A
G
A
--------
L
D
L
V
D
K
N
I
A
I
F
R
S
I
V
E
S
V
M
A
S
G
F
Q
G
L
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
H
E
R
V
I
G
S
G
T
I
L
D
T
A
R
F
R
F
L
L
G
E
Y
F
S
V
A
P
Q
N
V
-
H
A
Y
I
I
G
E
H
G
D
T
E
L
P
V
W
S
Q
A
Y
I
G
V
M
P
I
R
K
L
-------
V
----
E
S--------------
K
--
D
L
E
R
-----
I
F
V
N
----
V
R
D
A
A
Y
Q
I
I
E
K
K
G
A
T
Y
Y
G
I
A
M
G
L
A
R
V
T
R
A
I
L
H
N
E
N
A
I
L
T
V
S
A
Y
L
D
G
L
Y
G
E
R
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
E
V
I
E
I
E
L
N
D
D
E
K
N
R
F
H
H
S
A
A
T
L
K
S
V
L
A
R
A
F
T
R
--
71
PsiBlast_CBE
85.39
51%
-118
- C6 -
3WSW
4
?
B:
[3-311]
-
K
T
S
-
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
-
E
-
K
N
V
S
V
W
S
-
G
-
T
Y
E
E
-
C
Q
D
A
N
L
V
I
L
T
A
G
V
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
Q
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
-
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
-------
V
----
E
---
K
D
HRL--
E
---
E
N
--
D
L
T
V
-----
L
A
D
K
----
V
K
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
L
N
G
E
Y
G
E
E
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
-------
70
PsiBlast_CBE
85.23
51%
-123
- C6 -
3WSW
6
?
C:
[3-311]
-
K
T
S
-
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
-
E
-
K
N
V
S
V
W
S
-
G
-
T
Y
E
E
-
C
Q
D
A
N
L
V
I
L
T
A
G
V
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
Q
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
-
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
-------
V
----
E
---
K
D
HRL--
E
---
E
N
--
D
L
T
V
-----
L
A
D
K
----
V
K
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
L
N
G
E
Y
G
E
E
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
-------
15
PsiBlast_PDB
85.17
57%
-125
- C6 -
2LDB
5
LDH_GEOSE
A:
[8-317]
------
R
V
V
V
I
G
A
G
F
V
G
A
S
Y
V
F
A
L
M
N
Q
G
I
A
D
E
I
V
L
I
D
A
N
E
S
K
A
I
G
D
A
M
D
F
N
H
G
K
V
F
A
P
K
-
P
V
-
D
I
W
----
D
Y
D
D
-
C
R
D
A
D
L
V
V
I
C
A
G
A
--------
L
D
L
V
D
K
N
I
A
I
F
R
S
I
V
E
S
V
M
A
S
G
F
Q
G
L
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
H
E
R
V
I
G
S
G
T
I
L
D
T
A
R
F
R
F
L
L
G
E
Y
F
S
V
A
P
Q
N
V
-
H
A
Y
I
I
G
E
H
G
D
T
E
L
P
V
W
S
Q
A
Y
I
G
V
M
P
I
R
K
L
-------
V
----
E
S--------------
K
--
D
L
E
R
-----
I
F
V
N
----
V
R
D
A
A
Y
Q
I
I
E
K
K
G
A
T
Y
Y
G
I
A
M
G
L
A
R
V
T
R
A
I
L
H
N
E
N
A
I
L
T
V
S
A
Y
L
D
G
L
Y
G
E
R
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
E
V
I
E
I
E
L
N
D
D
E
K
N
R
F
H
H
S
A
A
T
L
K
S
V
L
A
R
A
F
T
R
--
59
PsiBlast_CBE
85.08
57%
-125
- C6 -
2LDB
5
LDH_GEOSE
C:
[8-317]
------
R
V
V
V
I
G
A
G
F
V
G
A
S
Y
V
F
A
L
M
N
Q
G
I
A
D
E
I
V
L
I
D
A
N
E
S
K
A
I
G
D
A
M
D
F
N
H
G
K
V
F
A
P
K
-
P
V
-
D
I
W
----
D
Y
D
D
-
C
R
D
A
D
L
V
V
I
C
A
G
A
--------
L
D
L
V
D
K
N
I
A
I
F
R
S
I
V
E
S
V
M
A
S
G
F
Q
G
L
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
H
E
R
V
I
G
S
G
T
I
L
D
T
A
R
F
R
F
L
L
G
E
Y
F
S
V
A
P
Q
N
V
-
H
A
Y
I
I
G
E
H
G
D
T
E
L
P
V
W
S
Q
A
Y
I
G
V
M
P
I
R
K
L
-------
V
----
E
S--------------
K
--
D
L
E
R
-----
I
F
V
N
----
V
R
D
A
A
Y
Q
I
I
E
K
K
G
A
T
Y
Y
G
I
A
M
G
L
A
R
V
T
R
A
I
L
H
N
E
N
A
I
L
T
V
S
A
Y
L
D
G
L
Y
G
E
R
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
E
V
I
E
I
E
L
N
D
D
E
K
N
R
F
H
H
S
A
A
T
L
K
S
V
L
A
R
A
F
T
R
--
58
PsiBlast_CBE
85.08
57%
-125
- C6 -
2LDB
5
LDH_GEOSE
D:
[8-317]
------
R
V
V
V
I
G
A
G
F
V
G
A
S
Y
V
F
A
L
M
N
Q
G
I
A
D
E
I
V
L
I
D
A
N
E
S
K
A
I
G
D
A
M
D
F
N
H
G
K
V
F
A
P
K
-
P
V
-
D
I
W
----
D
Y
D
D
-
C
R
D
A
D
L
V
V
I
C
A
G
A
--------
L
D
L
V
D
K
N
I
A
I
F
R
S
I
V
E
S
V
M
A
S
G
F
Q
G
L
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
H
E
R
V
I
G
S
G
T
I
L
D
T
A
R
F
R
F
L
L
G
E
Y
F
S
V
A
P
Q
N
V
-
H
A
Y
I
I
G
E
H
G
D
T
E
L
P
V
W
S
Q
A
Y
I
G
V
M
P
I
R
K
L
-------
V
----
E
S--------------
K
--
D
L
E
R
-----
I
F
V
N
----
V
R
D
A
A
Y
Q
I
I
E
K
K
G
A
T
Y
Y
G
I
A
M
G
L
A
R
V
T
R
A
I
L
H
N
E
N
A
I
L
T
V
S
A
Y
L
D
G
L
Y
G
E
R
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
E
V
I
E
I
E
L
N
D
D
E
K
N
R
F
H
H
S
A
A
T
L
K
S
V
L
A
R
A
F
T
R
--
69
PsiBlast_CBE
83.98
51%
-119
- C6 -
3WSW
5
?
D:
[3-311]
-
K
T
S
-
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
-
E
-
K
N
V
S
V
W
S
-
G
-
T
Y
E
E
-
C
Q
D
A
N
L
V
I
L
T
A
G
V
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
Q
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
-
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
-------
V
----
E
---
K
D
HRL--
E
---
E
N
--
D
L
T
V
-----
L
A
D
K
----
V
K
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
L
N
G
E
Y
G
E
E
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
-------
72
PsiBlast_CBE
83.59
51%
-120
- C6 -
3WSW
5
?
A:
[3-311]
-
K
T
S
-
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
-
E
-
K
N
V
S
V
W
S
-
G
-
T
Y
E
E
-
C
Q
D
A
N
L
V
I
L
T
A
G
V
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
Q
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
-
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
-------
V
----
E
---
K
D
HRL--
E
---
E
N
--
D
L
T
V
-----
L
A
D
K
----
V
K
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
L
N
G
E
Y
G
E
E
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
-------
117
HHSearch
83.37
51%
-116
- C6 -
3WSW
5
?
A:
[3-315]
-
K
T
S
-
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
-
E
K
N
V
-
S
V
W
S
-
G
-
T
Y
E
E
-
C
Q
D
A
N
L
V
I
L
T
A
G
V
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
Q
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
-
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
-------
V
----
E
---
K
D
HRL--
E
---
E
N
--
D
L
T
V
-----
L
A
D
K
----
V
K
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
L
N
G
E
Y
G
E
E
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
T
V
R
L
---
80
PsiBlast_CBE
79.20
39%
-104
- C6 -
2V7P
2
LDH_THET8
A:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
R
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
P
G
E
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
A
E
A
R
GRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
E
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
----------
93
PsiBlast_CBE
78.71
39%
-106
- C6 -
3VPH
4
LDH_THECA
C:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
R
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
P
G
E
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
AEARGRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
E
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
----------
78
PsiBlast_CBE
78.28
39%
-99
- C6 -
2V7P
2
LDH_THET8
C:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
R
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
P
G
E
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
A
E
A
R
G
R
A
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
E
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
----------
88
PsiBlast_CBE
78.26
39%
-104
- C6 -
2XXJ
3
LDH_THET8
B:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
W
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
P
G
E
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
A
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
AEARGRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
A
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
A
G
T
V
Y
P
S
L
S
P
E
E
R
A
A
L
R
R
S
A
E
I
L
K
E
----------
95
PsiBlast_CBE
78.15
39%
-106
- C6 -
3VPH
5
LDH_THECA
A:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
R
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
P
G
E
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
A
E
A
R
GRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
E
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
----------
99
PsiBlast_CBE
77.86
40%
-116
- C6 -
1LLD
1
LDH2_BIFL2
B:
[9-312]
------
K
L
A
V
I
G
A
G
A
V
G
S
T
L
A
F
A
A
A
Q
R
G
I
A
R
E
I
V
L
E
D
I
A
K
E
R
V
E
A
E
V
L
D
M
Q
H
G
S
S
F
Y
-
P
-
T
V
-
S
I
D
G
-
S
-
D
D
P
E
I
C
R
D
A
D
M
V
V
I
T
A
G
P
R
Q
K
P
G
Q
S
R
L
E
L
V
G
A
T
V
N
I
L
K
A
I
M
P
N
L
V
K
V
A
P
N
A
I
Y
M
L
I
T
N
P
V
D
I
A
T
H
V
A
Q
K
L
T
G
L
P
E
N
Q
I
F
G
S
G
T
N
L
D
S
A
R
L
R
F
L
I
A
Q
Q
T
G
V
N
V
K
N
V
-
H
A
Y
I
A
G
E
H
G
D
S
E
V
P
L
W
E
S
A
T
I
G
G
V
P
M
S
D
W
-------
T
----
P
---
L
P
-----
G
---
H
D
--
P
L
D
A
DKREE
I
H
Q
E
----
V
K
N
A
A
Y
K
I
I
N
G
K
G
A
T
N
Y
A
I
G
M
S
G
V
D
I
I
E
A
V
L
H
D
T
N
R
I
L
P
V
S
S
M
L
K
D
F
H
G
I
S
D
I
C
M
S
V
P
T
L
L
N
R
Q
G
V
N
N
T
I
N
T
P
V
S
D
K
E
L
A
A
L
K
R
S
A
E
T
L
K
E
----------
100
PsiBlast_CBE
77.53
40%
-120
- C6 -
1LLD
1
LDH2_BIFL2
A:
[9-312]
------
K
L
A
V
I
G
A
G
A
V
G
S
T
L
A
F
A
A
A
Q
R
G
I
A
R
E
I
V
L
E
D
I
A
K
E
R
V
E
A
E
V
L
D
M
Q
H
G
S
S
F
Y
-
P
-
T
V
-
S
I
D
G
-
S
-
D
D
P
E
I
C
R
D
A
D
M
V
V
I
T
A
G
P
R
Q
K
P
G
Q
S
R
L
E
L
V
G
A
T
V
N
I
L
K
A
I
M
P
N
L
V
K
V
A
P
N
A
I
Y
M
L
I
T
N
P
V
D
I
A
T
H
V
A
Q
K
L
T
G
L
P
E
N
Q
I
F
G
S
G
T
N
L
D
S
A
R
L
R
F
L
I
A
Q
Q
T
G
V
N
V
K
N
V
-
H
A
Y
I
A
G
E
H
G
D
S
E
V
P
L
W
E
S
A
T
I
G
G
V
P
M
S
D
W
-------
T
----
P
---
L
P
-----
G
---
H
D
--
P
L
D
A
D
K
R
E
E
I
H
Q
E
----
V
K
N
A
A
Y
K
I
I
N
G
K
G
A
T
N
Y
A
I
G
M
S
G
V
D
I
I
E
A
V
L
H
D
T
N
R
I
L
P
V
S
S
M
L
K
D
F
H
G
I
S
D
I
C
M
S
V
P
T
L
L
N
R
Q
G
V
N
N
T
I
N
T
P
V
S
D
K
E
L
A
A
L
K
R
S
A
E
T
L
K
E
----------
111
HHSearch
77.36
39%
-118
- C6 -
1LLD
1
LDH2_BIFL2
A:
[7-317]
---
P
-
T
K
L
A
V
I
G
A
G
A
V
G
S
T
L
A
F
A
A
A
Q
R
G
I
A
R
E
I
V
L
E
D
I
A
K
E
R
V
E
A
E
V
L
D
M
Q
H
G
S
S
F
Y
-
P
-
T
V
-
S
I
D
G
-
S
D
D
P
E
I
-
C
R
D
A
D
M
V
V
I
T
A
G
P
R
Q
K
P
G
Q
S
R
L
E
L
V
G
A
T
V
N
I
L
K
A
I
M
P
N
L
V
K
V
A
P
N
A
I
Y
M
L
I
T
N
P
V
D
I
A
T
H
V
A
Q
K
L
T
G
L
P
E
N
Q
I
F
G
S
G
T
N
L
D
S
A
R
L
R
F
L
I
A
Q
Q
T
G
V
N
V
K
N
V
-
H
A
Y
I
A
G
E
H
G
D
S
E
V
P
L
W
E
S
A
T
I
G
G
V
P
M
S
D
W
-------
T
----
P
---
L
P
GHDPL
D
---
A
D
--
K
R
E
E
-----
I
H
Q
E
----
V
K
N
A
A
Y
K
I
I
N
G
K
G
A
T
N
Y
A
I
G
M
S
G
V
D
I
I
E
A
V
L
H
D
T
N
R
I
L
P
V
S
S
M
L
K
D
F
H
G
I
S
D
I
C
M
S
V
P
T
L
L
N
R
Q
G
V
N
N
T
I
N
T
P
V
S
D
K
E
L
A
A
L
K
R
S
A
E
T
L
K
E
T
A
A
Q
F
-----
92
PsiBlast_CBE
77.07
39%
-105
- C6 -
3VPH
5
LDH_THECA
D:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
R
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
P
G
E
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
AEARGRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
E
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
----------
97
PsiBlast_CBE
76.93
40%
-116
- C6 -
1LTH
2
LDH2_BIFL2
T:
[9-312]
------
K
L
A
V
I
G
A
G
A
V
G
S
T
L
A
F
A
A
A
Q
R
G
I
A
R
E
I
V
L
E
D
I
A
K
E
R
V
E
A
E
V
L
D
M
Q
H
G
S
S
F
Y
-
P
-
T
V
-
S
I
D
G
-
S
-
D
D
P
E
I
C
R
D
A
D
M
V
V
I
T
A
G
P
R
Q
K
P
G
Q
S
R
L
E
L
V
G
A
T
V
N
I
L
K
A
I
M
P
N
L
V
K
V
A
P
N
A
I
Y
M
L
I
T
N
P
V
D
I
A
T
H
V
A
Q
K
L
T
G
L
P
E
N
Q
I
F
G
S
G
T
N
L
D
S
A
R
L
R
F
L
I
A
Q
Q
T
G
V
N
V
K
N
V
-
H
A
Y
I
A
G
E
H
G
D
S
E
V
P
L
W
E
S
A
T
I
G
G
V
P
M
S
D
W
-------
T
----
P
---
L
P
-----
G
---
H
D
--
P
L
D
A
DKREE
I
H
Q
E
----
V
K
N
A
A
Y
K
I
I
N
G
K
G
A
T
N
Y
A
I
G
M
S
G
V
D
I
I
E
A
V
L
H
D
T
N
R
I
L
P
V
S
S
M
L
K
D
F
H
G
I
S
D
I
C
M
S
V
P
T
L
L
N
R
Q
G
V
N
N
T
I
N
T
P
V
S
D
K
E
L
A
A
L
K
R
S
A
E
T
L
K
E
----------
86
PsiBlast_CBE
76.90
39%
-100
- C6 -
2XXJ
3
LDH_THET8
D:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
W
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
P
G
E
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
A
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
AEARGRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
A
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
A
G
T
V
Y
P
S
L
S
P
E
E
R
A
A
L
R
R
S
A
E
I
L
K
E
----------
98
PsiBlast_CBE
76.79
40%
-107
- C6 -
1LTH
3
LDH2_BIFL2
R:
[9-312]
------
K
L
A
V
I
G
A
G
A
V
G
S
T
L
A
F
A
A
A
Q
R
G
I
A
R
E
I
V
L
E
D
I
A
K
E
R
V
E
A
E
V
L
D
M
Q
H
G
S
S
F
Y
-
P
-
T
V
-
S
I
D
G
-
S
-
D
D
P
E
I
C
R
D
A
D
M
V
V
I
T
A
G
P
R
Q
K
P
G
Q
S
R
L
E
L
V
G
A
T
V
N
I
L
K
A
I
M
P
N
L
V
K
V
A
P
N
A
I
Y
M
L
I
T
N
P
V
D
I
A
T
H
V
A
Q
K
L
T
G
L
P
E
N
Q
I
F
G
S
G
T
N
L
D
S
A
R
L
R
F
L
I
A
Q
Q
T
G
V
N
V
K
N
V
-
H
A
Y
I
A
G
E
H
G
D
S
E
V
P
L
W
E
S
A
T
I
G
G
V
P
M
S
D
W
-------
T
----
P
---
L
P
-----
G
---
H
D
--
P
L
D
A
DKREE
I
H
Q
E
----
V
K
N
A
A
Y
K
I
I
N
G
K
G
A
T
N
Y
A
I
G
M
S
G
V
D
I
I
E
A
V
L
H
D
T
N
R
I
L
P
V
S
S
M
L
K
D
F
H
G
I
S
D
I
C
M
S
V
P
T
L
L
N
R
Q
G
V
N
N
T
I
N
T
P
V
S
D
K
E
L
A
A
L
K
R
S
A
E
T
L
K
E
----------
94
PsiBlast_CBE
76.17
39%
-103
- C6 -
3VPH
5
LDH_THECA
B:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
R
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
P
G
E
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
AEARGRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
E
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
----------
77
PsiBlast_CBE
75.57
39%
-106
- C6 -
2V7P
2
LDH_THET8
D:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
R
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
----------
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
AEARGRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
E
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
----------
79
PsiBlast_CBE
74.93
39%
-111
- C6 -
2V7P
2
LDH_THET8
B:
[2-303]
------
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
-
H
-
P
V
-
W
V
R
A
-
G
-
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
-----------
Q
L
L
D
R
N
A
Q
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
-
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
L
E
F
A
E
A
RGRA
L
----
S
---
P
E
-----
D
---
R
A
--
R
I
D
E
--------
G
----
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
V
E
G
V
L
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
----------
104
HHSearch
70.53
38%
-100
- C6 -
2X0J
2
MDH_ARCFU
A:
[1-293]
-----
M
K
L
G
F
V
G
A
G
R
V
G
S
T
S
A
F
T
C
L
L
N
L
D
V
D
E
I
A
L
V
D
I
A
E
D
L
A
V
G
E
A
M
D
L
A
H
A
A
A
G
I
-
D
K
Y
P
-
K
I
V
G
G
A
-
D
Y
S
L
-
L
K
G
S
E
I
I
V
V
T
A
G
L
A
R
K
P
G
M
T
R
L
D
L
A
H
K
N
A
G
I
I
K
D
I
A
K
K
I
V
E
N
A
P
E
S
K
I
L
V
V
T
N
P
M
D
V
M
T
Y
I
M
W
K
E
S
G
K
P
R
N
E
V
F
G
M
G
N
Q
L
D
S
Q
R
L
K
E
R
L
Y
N
A
---
G
A
R
N
I
R
R
A
W
I
I
G
E
H
G
D
S
M
F
V
A
K
S
L
A
D
F
D
G
E
V
-----------------------------------
D
W
E
A
-----
V
E
N
D
----
V
R
F
V
A
A
E
V
I
K
R
K
G
A
T
I
F
G
P
A
V
A
I
Y
R
M
V
K
A
V
V
E
D
T
G
E
I
I
P
T
S
M
I
L
Q
G
E
Y
G
I
E
N
V
A
V
G
V
P
A
K
L
G
K
N
G
A
E
-
V
A
D
I
K
L
S
D
E
E
I
E
K
L
R
N
S
A
K
I
L
R
E
R
L
E
E
L
G
----