@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0214: (2016-03-13 )
LKGLQQLIYEQKDIRAVLNALDEKEKAQLVTGLTGSSRALFASVVEGASKRPVVFVTHNLYHAQKLYDDLLSLMDVDRLFLYPADELISSELSISSPELRGQRVEALDFLLSGKPGIVIVPVAGLRKMLPPVSLWKHFNISIVEGEEIDPDVLRQKLVTMGYTMSGMVNTPGEFSVRGGIIDIYPITEEFPIRIELFDTEVDSLRFFDVETQRSTTRVEEFRLLPATEIILDQSYYPDIVKRLEKKMMLTLNELKEQEDKQALIENLEEDLEMLRSGVKPDMFFKYIGLAYPDPASLFDYLPKNTAILLDEFGRILETEESLEREEAEWQTETLSRMETVRDVQVSHSFKKLLEGNHSPKIYLSLFQKQMASMRVSKTTNIVYKQMQQFHGQMNVLKTELESWHKNNYAVVILAPNLERAEKMQQTLTDYDMESTILKKESDVPKYGMVQFVIGTFQNGFELPLAKVAIISETELFNKKIKKVKKRQKLSNAERIQSYSELKVGDYVVHVNHGIARYVGMETLDINGVHKDYLLLVYQGEDKLFIPVDQLDLVQKYVGAEGKSPRLNKLGGAEWKRVKKKVQASVQDIADDLIKLYAEREAEKGYAFSADDEMQREFEEAFPYQETEDQLRSISEIKKDMERPRPMDRLLVGDVGYGKTEVALRAAFKAIMDGKQVAFLVPTTILAQQHFETMKERFQGFPIEIGLLSRFRTKKQQTETLKGMKNGTVDVVVGTHRLLSKDVEYQDLGLLIVDEEQRFGVTHKEKIKQMRSKIDVLTLTATPIPRTLHMSMLGVRDLSVIETPPANRFPVQTYVAEQNNVLVREAIERELARDGQVYYLYNRVESITQKADEISAMVPDARVATAHGQMGESELESVILSFLEGEFDVLVTTTIIETGVDIPNVNTLFVQDADRMGLSQLYQLRGRVGRWNRIAYAYFMYQKDKILREEAEKRLSAIKEFTELGSGFKIAMRDLSIRGAGNILGAQQHGFIDSVGFDLYSQMLKEAIEAKKPKEEQKQIVPVEIDIQADAYIPEYYITDGRQKIEMYKRFRNIETLSELEDLQSDMIDRFGEYPEEVEYLFTMTELKVRALEVGIESVKQEQNKITMLFSESGTAGIRGDIVMQIIGEFGRMVGVGMEGTQLKITINVQNKPLKEWLYQVKSLAEKLRGAMKEKASTEN
Atome Classification :
(20 SA)
---.........------10........20........30.....--...40........50..--.......60........70-----------........--.--------------80.-------------.......90....-....100.......110.......120.......130.......140.......150.......160.......170.......180....-.-..190.......200.......210.......220.......230.......240.......250...---...---.260.......270...-----....---280....---...290--.--.-.....300.......310-........320.......330...---....-----340-------------.....--..-----350.....-..360...----.----...370-...--.....380---..-..---------.....------390.......400.......410.......420.......430..---...-------..440-------......--.--..450...--....460.......470.-......480.-----.--.--.-...490.......------500..--------.....510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610....--...620--------------.-......630.......640.......650.......660.......670--.---.......680.......690.......700........710.......720.......730.......740----.-----........750.......760-..------..------.....770.......780.......790..--.....800-..--......810.....-.-.820-----------........--830.........840..-----------------------.....850...-----.-.-..860......-------.870.......880----------------.......890.......900.......910..-----.----------....920........930.......940.......950.......960.......970.......980.......990.-----......1000......----1010--........1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---LK
G
L
Q
Q
L
I
Y
------
E
Q
K
D
I
R
A
V
L
N
AL
D
E
K
E
K
A
Q
LVTGLTGS--
S
R
A
L
F
A
S
V
V
EGASK-R
P
--
V
V
F
V
THN
L
Y
H
A
Q
K
L
Y
D
D
L
------------
L
S
L
M
D
V
D
R
--
L
--------------FLY-------------
P
A
D
E
L
I
S
S
ELSIS-SPELRG
Q
R
V
E
A
L
D
F
L
LSGKP
G
I
V
I
V
P
V
A
G
L
R
KMLP
P
V
S
L
W
KHF
N
I
S
I
VEGEEI
D
P
D
V
L
R
Q
K
L
V
T
MGYTMSGMVNTPG
E
F
S
VRG
G
I
I
D
I
Y
PI-T-EEF
P
I
R
I
E
L
FDTEVD
S
L
R
F
F
D
V
ETQRSTT
R
V
E
E
F
RLLP
A
T
E
I
I
LDQSY
Y
P
D
I
V
K
R
L
E
K
K
M
M
L
T
L
N
E
L
K
---
E
Q
E
---
D
K
Q
A
L
I
E
N
L
E
E
D
L
E
M
L
R
-----SGV
K
---
P
D
M
F
F
K
Y
---IGLAYP--
D
--
P
-
A
S
L
F
D
YLPKN
T
A
I
L
L
D
E
--
F
G
R
I
L
E
T
E
E
S
L
E
R
E
E
A
E
W
Q
T
E
T
L
S
---
R
M
E
T
-----
V
R
D
-------------
V
Q
V
S
H
--
S
F
-----
K
K
L
L
EGNH-SP
K
I
Y
L
S
L
----
F
----
Q
K
Q
M
A
--
S
M
R--VS
K
T
T
N
-----
I
V
-
Y
K
---------
Q
M
Q
Q
F
------HGQ
M
N
V
L
K
T
E
L
E
S
W
HKN
N
Y
A
V
V
I
LAP
N
L
E
R
A
E
K
M
Q
Q
T
L
T
D
Y
D
M
E
S
---
T
I
L
-------KKE---------SDVPK
Y
--
G
--
M
V
Q
F
V
I
G
T
--FQNGFELP
L
A
K
V
A
I
I
S
E
T
-
E
L
F
N
K
K
I
K
K
V
-----
K
--
K
--
R
-
Q
KLS
N
A
E
R
I
Q
S
Y
S
------ELKVG--------
D
Y
V
V
H
VNHG
I
A
R
Y
VG
M
E
T
L
DINGVH
K
D
Y
L
L
L
V
Y
QGE
D
K
L
F
I
P
V
D
Q
L
D
L
V
Q
K
Y
VGAEGKSPRLNKLG
G
A
E
W
K
R
V
K
K
K
V
Q
A
S
V
Q
D
I
A
D
D
L
I
K
L
Y
A
E
R
EAEKG
Y
A
FSA
D
D
E
M
Q
R
E
--
F
E
E
AFP--------------Y-
Q
E
T
E
D
Q
L
R
S
I
S
E
I
K
K
D
M
ERPR
P
M
D
R
L
L
VGDVGY
G
K
T
E
V
A
L
R
A
A
F
K
A
I
M---D---G
K
Q
V
A
F
L
V
P
T
T
I
L
A
Q
Q
H
F
E
T
M
K
E
R
FQGFP-I
E
I
G
L
L
S
R
F
R
T
K
K
Q
Q
T
E
T
L
KGMKNG
T
V
D
V
V
VG
T
H
R
L
L
SK------D-----VEYQD
L
G
L
L
I
VDE
E
Q
RFGV---
T
H
------
K
E
------
K
I
K
Q
M
R
SKI
D
V
L
T
L
TATPIP
R
T
L
H
M
S
M
LGV--
R
D
L
S
V
IE--TP--PANRF
P
V
Q
T
Y
VAEQ-N-N
V
L
------------
V
R
E
A
I
E
R
E
--
L
--ARDG
Q
V
Y
Y
L
Y
N
R
V
E
-----------------------
S
I
T
Q
K
A
D
E
I
S
A
-----M-V-PD
A
R
V
A
TAHGQ-------M
G
E
S
E
L
E
S
V
I
L
S
F
L----------------EGE
F
D
V
L
V
T
T
T
I
IETGVDIPNV
N
T
L
F
VQ
D
A
D
R
-----
M
----------
G
L
S
Q
L
Y
-
Q
L
RGRVGR
W
N
R
I
A
Y
A
Y
F
M
Y
Q
K
D
K
I
L
R
E
E
A
E
K
R
L
S
A
I
K
E
F
T
E
LGSG
F
K
I
A
M
R
D
L
S
IRGAGNILGAQQHG
F
I
D
S
-----
V
G
F
D
L
Y
S
Q
M
L
K
E
A
I
E
A----KK----P
K
E
E
QK
Q
I
V
P
V
E
I
D
I
QADAYI
P
E
Y
Y
ITD
G
R
Q
K
I
E
M
Y
K
R
FRN
I
E
T
L
S
E
L
E
D
L
Q
S
D
M
I
D
R
FGE
Y
P
E
E
V
E
Y
L
F
T
M
T
E
L
K
V
R
A
L
E
V
G
I
E
S
V
K
QEQN
K
I
T
M
L
FSESGTAG
I
R
G
D
I
V
M
Q
I
I
G
E
F
G
R
MVGVGMEG
T
Q
L
K
I
T
I
N
VQNK
P
L
K
E
W
L
Y
Q
V
K
S
L
A
E
K
L
R
G
A
M
K
EKASTEN
80
Fugue
86.70
36%
-79
- C1 -
2EYQ
5
MFD_ECOLI
A:
[5-1150]
------
P
E
Q
Y
R
Y
---------------
T
L
P
V
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
--
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
------------
S
Q
F
T
D
Q
M
V
--
M
--------------
N
L
A
-------------
D
W
E
T
L
P
Y
D
S
F
S
P
H
--
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
-
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
-------
E
---
V
K
R
---
D
P
E
H
I
Y
Q
Q
V
S
K
------------
G
T
L
---
P
A
G
I
E
Y
W
---
Q
P
L
F
F
S
--
E
--
P
L
P
P
L
F
S
Y
F
P
A
N
T
-----------
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
---
R
F
E
N
-----
R
G
V
DPM
R
P
L
L
P
PQSLW
L
R
V
D
E
--
L
F
-----
S
E
L
---
K
N
-
W
P
R
V
Q
L
K
T
----
E
HLPT
K
A
A
N
A
--
N
L
G
--
F
Q
K
L
P
D
-----
L
A
-
V
Q
---------
A
Q
Q
K
--------
A
P
L
D
A
L
R
K
F
L
E
T
F
---
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
---
Q
R
I
-------
M
R
L
---------
D
E
A
S
D
R
--
G
--
R
-
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
-
D
L
L
G
E
R
V
A
R
R
-----
R
QD
S
--
R
-
R
T
I
N
P
D
T
L
I
R
N
L
A
------
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
--
F
C
D
S
F
P
--------------
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
---
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
W
P
-
V
R
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
------
D
-----
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
R
F
G
V
---
R
H
------
K
E
------
R
I
K
A
M
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
G
M
--
R
D
L
S
I
I
A
--
T
P
--
P
A
R
R
L
A
V
K
T
F
V
R
E
Y
-
D
-
S
M
V
------------
V
R
E
A
I
L
R
E
--
I
--
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
-----------------------
N
I
Q
K
A
A
E
R
L
A
E
-----
L
-
V
-
P
E
A
R
I
A
I
G
H
G
Q
-------
M
R
E
R
E
L
E
R
V
M
N
D
F
H
----------------
H
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
-----
F
----------
G
L
A
Q
L
H
-
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
-----
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
----
L
K
A
GRE
P
S
L
E
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
K
N
--
H
V
N
P
A
W
L
I
G
L
L
Q
K
Q
P
Q
H
Y
R
L
D
-
G
P
T
R
L
K
F
I
Q
D
---------
L
S
E
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
A
I
21
PsiBlast_CBE
81.66
36%
-73
- C1 -
2EYQ
5
MFD_ECOLI
B:
[20-1094]
------------------------------------
R
L
L
G
E
L
T
G
A
--
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
TD
Q
M
V
----
M
N
L
A
D
W
E
T
--
L
------------------------------
P
Y
D
S
F
S
P
H
Q
D
I
I
S
-
S
------
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
-
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
-----
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
---
R
-----
D
P
E
H
I
Y
Q
Q
V
S
K
G
--
T
L
P
-----
A
G
I
E
------
Y
W
Q
P
---
L
F
F
S
E
P
--
L
--
P
--
P
L
F
S
Y
F
P
A
N
T
--
L
L
V
N
--
T
G
---
D
L
E
T
S
A
E
R
----
F
Q
A
D
T
L
A
---
R
F
E
N
RGVDP
M
R
P
-------------
L
L
P
P
Q
--
S
L
WLR
V
D
E
L
F
S
E
L
K
N
-
W
P
R
V
Q
L
K
T
E
H
L
P
T
----
K
A
A
N
A
--
N
L
G
--
F
Q
K
L
P
D
-----
L
A
-
V
Q
---------
A
Q
Q
K
--------
A
P
L
D
A
L
R
K
F
L
E
T
F
---
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
-------
D
E
A
---------
S
D
R
G
R
Y
--
L
--
M
----
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
-
D
L
L
G
E
R
V
A
R
R
-----
R
--
Q
DS
R
-
R
T
I
N
P
D
T
L
I
R
N
L
A
------
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
--
F
C
D
S
F
P
--------------
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
---
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
W
P
-
V
R
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
------
D
-----
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
R
F
G
V
---
R
H
------
K
E
------
R
I
K
A
M
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
G
M
--
R
D
L
S
I
I
A
--
T
P
--
P
A
R
R
L
A
V
K
T
F
V
R
E
Y
-
D
-
S
M
V
------------
V
R
E
A
I
L
R
E
--
I
--
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
-----------------------
N
I
Q
K
A
A
E
R
L
A
E
-----
L
-
V
-
P
E
A
R
I
A
I
G
H
G
Q
-------
M
R
E
R
E
L
E
R
V
M
N
D
F
H
----------------
H
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
-----
F
----------
G
L
A
Q
L
H
-
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
-----
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
G
R
E
----
P
S
L
E
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
--------------------------------------------------------------------
1
PsiBlast_PDB
80.75
36%
-75
* C1 *
2EYQ
5
MFD_ECOLI
A:
[20-1094]
------------------------------------
R
L
L
G
E
L
T
G
A
--
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
V
----
M
N
L
A
D
W
E
T
--
L
------------------------------
P
Y
D
S
F
S
P
H
Q
D
I
I
S
-
S
------
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
-
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
-----
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
---
R
-----
D
P
E
H
I
Y
Q
Q
V
S
K
G
--
T
L
P
-----
A
G
I
E
------
Y
W
Q
P
---
L
F
F
S
E
P
--
L
--
P
--
P
L
F
S
Y
F
P
A
N
T
--
L
L
V
N
--
T
G
---
D
L
E
T
S
A
E
R
----
F
Q
A
D
T
L
A
---
R
F
E
N
R
GVDP
M
R
P
-------------
L
L
P
P
Q
--
S
L
WLR
V
D
E
L
F
S
E
L
K
N
-
W
P
R
V
Q
L
K
T
EHLP
T
----
K
A
A
N
A
--
N
L
G
--
F
Q
K
L
P
D
-----
L
A
-
V
Q
---------
A
Q
Q
K
--------
A
P
L
D
A
L
R
K
F
L
E
T
F
---
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
-------
D
E
A
---------
S
D
R
G
R
Y
--
L
--
M
----
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
-
D
L
L
G
E
R
V
A
R
R
-----
R
--
Q
DS
R
-
R
T
I
N
P
D
T
L
I
R
N
L
A
------
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
--
F
C
D
S
F
P
--------------
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
---
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
W
P
-
V
R
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
------
D
-----
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
R
F
G
V
---
R
H
------
K
E
------
R
I
K
A
M
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
G
M
--
R
D
L
S
I
I
A
--
T
P
--
P
A
R
R
L
A
V
K
T
F
V
R
E
Y
-
D
-
S
M
V
------------
V
R
E
A
I
L
R
E
--
I
--
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
-----------------------
N
I
Q
K
A
A
E
R
L
A
E
-----
L
-
V
-
P
E
A
R
I
A
I
G
H
G
Q
-------
M
R
E
R
E
L
E
R
V
M
N
D
F
H
----------------
H
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
-----
F
----------
G
L
A
Q
L
H
-
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
-----
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
G
R
E
----
P
S
L
E
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
--------------------------------------------------------------------
61
HHSearch
63.34
39%
-64
- C1 -
1GM5
2
?
A:
[348-740]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
P
K
K
I
E
G
K
L
A
E
E
--
F
I
K
S
L
P
--------------
F
-
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
---
A
---
G
F
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
F
N
-
I
H
V
A
L
L
I
G
A
T
T
P
S
E
K
E
K
I
K
S
G
L
R
N
G
Q
I
D
V
V
I
G
T
H
A
L
I
Q
E
------
D
-----
V
H
F
K
N
L
G
L
V
I
I
D
E
Q
H
R
F
--------------
E
------
A
L
M
N
K
G
K
M
V
D
T
L
V
M
S
A
T
P
I
P
R
S
M
A
L
A
F
Y
G
D
--
L
D
V
T
V
I
D
--
E
M
--
P
P
G
R
K
E
V
Q
T
M
L
V
P
M
-
D
R
V
N
E
------------
V
Y
E
F
V
R
Q
E
--
V
--
M
R
G
G
Q
A
F
I
V
Y
P
L
I
K
-----------------------
S
A
V
E
M
Y
E
Y
L
S
K
-----
E
V
F
----
K
L
G
L
M
H
G
R
-------
L
S
Q
E
E
K
D
R
V
M
L
E
F
A
----------------
E
G
R
Y
D
I
L
V
S
T
T
V
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
E
N
P
E
R
-----
F
----------
G
L
A
Q
L
H
-
Q
L
R
G
R
V
G
R
G
G
Q
E
A
Y
C
F
L
V
V
G
D
V
G
---
E
E
A
M
E
R
L
R
F
F
T
L
---
N
T
D
G
F
K
I
A
E
Y
D
L
K
T
R
G
P
G
E
----
K
Q
H
G
L
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.27
37%
-64
- C1 -
1GM5
2
?
A:
[338-750]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
K
E
R
E
K
H
G
G
I
P
K
K
I
E
G
K
L
A
E
E
--
F
I
K
S
L
P
--------------
F
-
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
---
A
---
G
F
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
F
N
-
I
H
V
A
L
L
I
G
A
T
T
P
S
E
K
E
K
I
K
S
G
L
R
N
G
Q
I
D
V
V
I
G
T
H
A
L
I
Q
E
------
D
-----
V
H
F
K
N
L
G
L
V
I
I
D
E
Q
H
R
F
--------------
E
------
A
L
M
N
K
G
K
M
V
D
T
L
V
M
S
A
T
P
I
P
R
S
M
A
L
A
F
Y
G
D
--
L
D
V
T
V
I
D
--
E
M
--
P
P
G
R
K
E
V
Q
T
M
L
V
P
M
-
D
-
R
V
N
E
-----------
V
Y
E
F
V
R
Q
E
--
V
--
M
R
G
G
Q
A
F
I
V
Y
P
L
I
-K----------------------
S
A
V
E
M
Y
E
Y
L
S
K
-----
E
-
V
F---
K
L
G
L
M
H
G
R
-------
L
S
Q
E
E
K
D
R
V
M
L
E
F
A
----------------
E
G
R
Y
D
I
L
V
S
T
T
V
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
E
N
P
E
R
-----
F
----------
G
L
A
Q
L
H
-
Q
L
R
G
R
V
G
R
G
G
Q
E
A
Y
C
F
L
------
V
V
G
D
V
G
E
E
A
M
E
R
L
R
F
F
T
L
N
T
D
G
F
K
I
A
E
Y
D
L
K
T
R
G
P
G
E
----
K
Q
H
G
L
S
G
F
-----
K
V
A
D
L
Y
R
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
62.49
20%
-62
- C1 -
2D7D
2
UVRB_BACSU
A:
[32-643]
---------------------------------
K
K
H
Q
T
L
L
G
A
T
G
T
--
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
------------
K
E
F
F
P
N
N
A
--
V
--------------
E
Y
F
V
SYYD
Y
Y
Q
P
EAYV
P
Q
T
D
T
F
-
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
-
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
-
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
---
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
-----
E
M
G
F
---
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
--
G
ST
P
-
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
--
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
---
H
G
F
R
-----
L
P
S
AL-----------
D
N
R
P
L
--
R
F
-----
E
E
F
E
K
H
M
H
--
N
I
V
Y
V
S
A
----
T
----
P
G
P
Y
E
I
E
H
T
D
EM
V
E
Q
I
I
R
PTGLL
D
P
-
L
I
---------
D
V
R
P
I
------
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
---
N
Y
L
-------
H
S
E
IK
T
L
E
R
I
E
I
I
R
D
L
R
L
--
G
KY
D
V
L
V
G
I
N
L
--
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
-
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
--
G
--
R
A
A
R
N
A
E
G
R
V
I
M
Y
A
D
KIT
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
------
P
K
T
I
N
--------------------------------------------
K
K
E
R
Q
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
59.03
22%
-60
- C1 -
3HJH
1
MFD_ECOLI
A:
[14-450]
---------------------------------
G
E
Q
R
L
L
G
E
L
T
G
A
--
A
C
A
T
L
V
A
E
I
A
E
R
-
H
A
G
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
------------
S
Q
F
T
D
-
Q
M
--
V
--------------
M
N
L
-------------
A
D
W
E
T
L
P
Y
D
S
F
S
P
-
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
-
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
--------------------
D
P
E
H
I
Y
Q
Q
V
S
-----
K
G
T
L
---
P
A
G
I
E
Y
W
---
Q
P
L
F
F
S
--
E
P-
L
-
P
P
L
F
S
Y
F
P
A
N
T
L
L
--
V
N
--
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D--
P
M
R
P
-----
L
L
P
P------------
Q
S
L
W
L
--
R
V
-----
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
T
----
E
----
H
L
P
T
--------
K
A
A
N
A
N
-----
L
G
-
F
Q
---------
K
L
P
D
L
AVQAQQ
K
A
P
L
D
A
L
R
K
F
L
E
T
F
---
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
---
Q
R
I
-------
M
R
L
----------
D
E
A
S
D
--
R
--
G
R
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
-
D
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
58.43
20%
-64
- C1 -
3HJH
1
MFD_ECOLI
A:
[5-450]
------------------------
Y
R
Y
T
L
P
V
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
--
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
------------
S
Q
F
T
D
-
Q
M
--
V
--------------
M
N
L
-------------
A
D
W
E
T
L
P
Y
D
S
F
S
P
-
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
-
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
-------
E
---
V
K
R
---
D
P
E
H
I
Y
Q
Q
V
S
K
------------
G
T
L
---
P
A
G
I
E
Y
W
---
Q
P
L
F
F
S
--
E
--
P
L
P
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
---
P
L
L
P
-----
P
Q
S
-------------
L
W
L
R
----------
V
D
E
L
F
S
E
L
-
K
N
W
P
R
V
Q
L
----
K
----
T
E
H
L
P
--
T
K
A
--
A
N
A
N
L
G
-----
F
Q
K
L
P
---------
D
L
A
V
Q
------
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
---
Q
R
I
-------
M
R
L
---------
D
E
A
S
D
R
--
G
---
R
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
-
D
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.41
23%
-74
- C1 -
2NMV
3
?
A:
[19-370]
--------------------
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
--
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
------------
K
E
F
F
P
N
N
A
--
V
E
Y
F
V
S
YYDYYQ
P
E
A
Y
V
P
-------------
Q
T
D
T
F
I
E
K
D
A
S
I
N
-
D
-
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
-
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
-
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
---
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
MGFC
S
G
I
-----
E
N
Y
S
R
H
---
L
T
L
R
P
P
GS
T
--
P
-
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.05
23%
-77
- C1 -
2D7D
2
UVRB_BACSU
A:
[19-370]
--------------------
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
--
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
------------
K
E
F
F
P
N
N
A
--
V
E
Y
F
V
SYYD
Y
Y
Q
P
EA
Y
V
P
-------------
Q
T
D
T
F
I
E
K
D
A
S
I
N
-
D
-
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
-
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
-
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
---
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
MGFC
S
G
I
-----
E
N
Y
S
R
H
---
L
T
L
R
P
P
GS
T
--
P
-
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Fugue
57.01
16%
-38
- C1 -
1D2M
4
UVRB_THET8
A:
[2-583]
TFR
Y
R
G
P
S
P
K
G
D
------
Q
P
K
A
I
A
G
L
V
E
A
L
R
D
G
E
R
F
V
T
L
L
G
A
T
G
T
--
G
K
T
V
T
M
A
K
V
I
E
A
L
G
-
R
P
--
A
L
V
L
A
P
N
K
I
L
A
A
Q
L
A
A
E
F
------------
R
E
L
F
P
E
N
A
--
V
--------------
E
Y
F
ISYYDYYQ
P
E
A
Y
V
P
G
K
D
L
Y
I
E
K
D
A
S
I
-
N
P
E
I
E
R
L
R
H
S
T
T
R
S
L
L
T
R
R
D
V
I
V
V
A
S
V
S
A
I
Y
G
L
G
D
P
R
E
Y
R
A
R
--------
N
L
V
V
R
E
V
L
L
E
R
L
L
E
L
G
Y
Q
R
N
D
I
D
L
S
P
G
R
F
R
A
K
G
E
V
L
E
I
F
P
A
-
Y
-
E
T
E
P
I
R
V
E
-
L
G
F
V
L
F
P
A
T
H
Y
L
S
P
E
G
L
E
E
I
L
K
E
I
E
K
E
L
W
E
R
V
R
Y
F
E
E
R
G
E
V
L
Y
A
Q
R
L
K
E
R
T
L
Y
D
L
E
M
L
R
---
V
M
G
---
T
C
P
G
-
V
E
N
Y
A
R
Y
F
T
G
K
A
-----
P
G
--------------------
E
--
P
--
P
-
Y
T
L
L
D
Y
F
P
E
D
F
L
V
F
L
D
E
--
S
H
V
T
V
P
Q
L
Q
G
M
Y
R
G
D
Y
A
R
K
K
T
L
V
D
Y
GF
R
L
P
S
-----
A
L
D
-------------
N
R
P
L
R
---------
F
E
E
F
L
E
R
V
-
S
Q
V
V
F
V
S
A
----
T
----
P
G
P
F
E
--
L
A
H
--
S
G
R
V
V
E
-----
Q
I
-
I
R
PTGLLD
P
L
V
R
V
K
P
T
------
E
N
Q
I
L
D
L
M
E
G
I
R
E
R
A
A
R
G
E
R
T
L
V
T
V
L
T
V
R
M
A
E
E
L
T
S
F
L
V
E
H
G
I
R
A
---
R
Y
L
HHELDA
F
K
R
Q
---------
A
L
I
R
D
L
R
L
G
--
H
Y
D
C
L
V
G
I
NL
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
-
D
------
K
E
G
-----
F
--
L
--
R
-
S
E
R
S
L
I
Q
T
I
G
R
A
A
------
R
N
A
R
G
--------
E
V
W
L
Y
A
D
R
---
V
S
E
A
M
Q
R
A
I
E
E
T
N
R
R
R
A
L
Q
E
A
Y
N
L
E
H
G
I
T
P
E
T
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.09
24%
-75
- C1 -
1T5L
-
UVRB_BACCA
A:
[21-339]
----------------------
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
--
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
PH
N
A
V
E
Y
F
V
S
Y
Y
D
Y
A
Q
P
E
A
--------------
Y
V
P
-------------
Q
T
D
T
Y
I
E
K
D
A
K
I
N
-
D
-
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
-
Y
R
E
L
V
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
-
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
---
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
MGFC
S
G
I
-----
E
N
Y
S
R
H
---
L
A
L
R
P
P
GS
T
--
P
-
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
55.88
24%
-59
- C1 -
3HJH
1
MFD_ECOLI
A:
[17-450]
------------------------------------
R
L
L
G
E
L
T
G
A
--
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
DQ
M
V
----
M
N
L
A
D
W
E
T
--
L
------------------------------
P
Y
D
S
F
S
P
H
Q
D
I
I
S
-
S
------
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
-
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
-----
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
---
R
-----
D
P
E
H
I
Y
Q
Q
V
S
K
G
--
T
L
P
-----
A
G
I
E
------
Y
W
Q
P
---
L
F
F
S
E
P
--
L
--
P
--
P
L
F
S
Y
F
P
A
N
T
-----------
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
---
R
F
E
N
R
GVDP
M
R
P
-------------
L
L
P
P
Q
--
S
L
WLR
V
D
E
L
F
S
E
L
K
N
-
W
P
R
V
Q
L
K
T
EHLP
T
----
K
A
A
N
A
--
N
L
G
--
F
Q
K
L
P
D
-----
L
A
-
V
Q
---------
A
Q
Q
K
--------
A
P
L
D
A
L
R
K
F
L
E
T
F
---
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
-------
D
E
A
---------
S
D
R
G
R
Y
--
L
--
M
----
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
-
D
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
55.64
23%
-74
- C1 -
3V4R
2
UVRB_BACSU
A:
[25-345]
--------------------
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
--
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
------------
K
E
F
F
P
N
N
A
--
V
E
Y
F
V
S
YYD
Y
Y
Q
P
EA
Y
V
P
-------------
Q
T
D
T
F
I
E
K
D
A
S
I
N
-
D
-
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
-
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
---R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
---
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
MGFC
S
G
I
-----
E
N
Y
S
R
H
---
L
T
L
R
P
P
G
S
T
--
P
-
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
55.21
19%
-49
- C1 -
3FHT
4
DD19B_HUMAN
A:
[34-380]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
L
Q
G
--
V
Y
A
M
G
F
--------------
N
-
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
----
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
---
P
ANK
Y
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
E
L
K
L
A
Y
A
V
R
G
N
K
-------
L
E
R
G
Q
K
I
S
E
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
SKLK
F
-----
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
---
T
Q
GH
Q
D
Q
S
I
R
------
I
Q
R
M
L
P
R
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
--
P
D
P
N
V
I
K
--
L
K
RE
E
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
S
-
R
D
E
------------
K
F
Q
A
L
C
N
L
--
Y
GA
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
-----------------------
T
A
S
W
L
A
A
E
L
S
K
-----
E
----
G
H
Q
V
A
L
L
S
G
E
-------
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
----------------
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGN
P
----------
D
N
E
T
Y
L
-
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
54.90
18%
-49
- C1 -
3PEY
10
DBP5_YEAST
A:
[13-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
E
L
L
K
G
--
I
Y
A
M
K
F
--------------
Q
-
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
----
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
PED
A
---
S
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
-
I
T
S
Q
L
I
V
P
D
S
--------
F
E
K
N
K
Q
I
N
A
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K-
L
-----
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
---
Q
Q
G
L
G
D
Q
C
I
R
------
V
K
R
F
L
P
K
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
LQ
T
N
--
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
A
D
------------
K
F
D
V
L
T
E
L
Y
G
L
--
M
T
I
G
S
S
I
I
F
V
A
T
K
K
-----------------------
T
A
N
V
L
Y
G
K
L
K
S
-----
E
----
G
H
E
V
S
I
L
H
G
D
-------
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
----------------
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQ
A
----------
D
P
A
T
Y
I
-
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Fugue
54.77
20%
-30
- C1 -
4NL4
3
?
H:
[18-747]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
A
H
V
A
L
P
V
P
L
P
R
---------
T
F
D
Y
L
------
L
-------
P
E
G
---------
M
A
V
K
A
G
--
C
--
R
V
R
V
P
F
G
----------
K
Q
E
R
I
G
I
V
A
A
V
S
E
R
S
E
L
P
L
D
E
L
-----
K
--
P
--
V
-
A
E
A
L
D
D
E
P
V
F
S
T
T
------
V
W
R
L
L
--------
M
W
A
A
E
Y
Y
H
H
P
I
G
D
V
L
F
H
A
L
P
---------
V
M
L
R
Q
G
K
-----
P
A
S
A
T
P
L
W
Y
W
F
A
T
E
Q
G
Q
V
V
D
L
N
G
L
K
R
S
------
R
K
Q
Q
Q
A
L
A
A
L
R
Q
G
--
K
I
W
R
H
Q
V
G
E
L
E
F
N
E
A
A
L
Q
A
L
R
G
K
GL
A
E
L
A
C
E
ATDWRSAYSVAGER
L
-
R
L
N
T
E
Q
A
T
A
V
G
A
I
H
S
--
A
A
D
R
F
S
A
W
L
L
A
G
I
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
V
L
A
---
Q
---
G
R
Q
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
A
----
P
V
E
V
L
H
S
G
L
N
D
S
E
R
L
S
A
W
L
K
A
K
N
G
E
A
A
I
V
I
G
T
R
S
S
L
F
T
------
P
-------
F
K
D
L
G
V
I
V
I
D
E
E
H
D
S
S
Y
---
K
Q
------
Q
E
------
G
W
R
Y
H
A
R
D
L
A
V
W
R
A
H
S
E
Q
I
P
I
I
L
G
S
A
T
P
A
L
--
E
T
L
H
N
V
R
--
Q
G
--
K
Y
R
Q
L
T
L
S
K
P
A
Q
Q
H
-
V
-
L
D
L
KGQPLQAGLSPA
L
I
S
R
M
R
Q
H
--
L
--
Q
A
D
N
Q
V
I
L
F
L
N
R
R
G
FAPALLCHDCGWIAECPRCDSYY
T
L
H
Q
A
Q
H
H
L
R
C
HHCDS
Q
-
R
-
P
I
P
R
Q
C
P
S
C
G
S
THLVPVG
I
G
T
E
Q
L
E
Q
A
L
A
P
L
F
PEVPISRIDRHLAAVH
R
G
G
A
R
I
L
I
G
T
Q
M
L
A
K
G
H
H
F
P
D
V
T
L
V
S
L
L
D
V
D
G
-----
A
LFSADFRSAE
R
F
A
Q
L
Y
T
Q
V
S
G
R
A
G
R
A
G
K
Q
G
E
V
I
L
Q
T
H
H
P
E
---------
H
P
L
L
Q
T
L
L
Y
K
G
-
Y
D
A
F
A
E
Q
A
L
A
E
R
Q
T
M
Q
L
P
P
W
T
S
H
V
L
I
R
A
EDHNN
Q
Q
A
P
L
F
L
Q
Q
L
R
N
L
L
Q
A
----
S
-----
P
L
A
D
E
K
L
W
V
L
G
P
V
P
-
A
L
R
W
Q
I
L
L
Q
H
P
S
R
V
R
L
Q
H
I
V
S
G
T
L
A
L
I
N
T
L
P
E
A
W
V
L
D
V
D
P
I
E
G
--------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
54.49
23%
-70
- C1 -
3UWX
-
?
B:
[58-364]
----------------------------------
K
H
Q
T
L
L
G
A
T
G
T
--
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
H
S
E
L
------------
K
E
F
F
P
H
N
A
--
V
E
Y
F
V
S
YYDYYQ
P
E
A
Y
V
P
-------------
Q
T
D
T
Y
I
E
K
D
A
K
I
N
-
D
-
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
-
Y
R
E
L
V
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
-
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
---
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
MGFC
S
G
I
-----
E
N
Y
S
R
H
---
L
A
L
R
P
P
GS
T
--
P
-
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Fugue
53.81
19%
-52
- C1 -
1D9X
1
UVRB_BACCA
A:
[2-414]
---
E
G
R
F
Q
L
V
A
P
YEPQGD
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-----KP
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
------------
K
E
F
F
P
H
N
A
--
V
E
Y
F
V
S
YYDYYQP
E
-
A
Y
V
-------------
P
Q
T
D
T
Y
I
E
K
D
A
K
I
-
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
--
F
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
-
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
A
--
E
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
---
A
Q
G
KLL
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
-----
E
M
G
F
CSG
I
E
N
Y
S
R
H
---
L
A
L
R
P
P
G
S
T
--
P
-
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
--
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
---
H
G
F
R
-----
L
P
S
-------------
A
L
D
N
R
P
L
T
F
-----
E
E
F
E
Q
K
I
N
-
Q
I
I
Y
V
S
A
T
----
P
----
G
P
Y
E
L
--
E
H
S
--
P
-----------
G
-
V
V
---------
E
Q
I
I
R
------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
53.76
20%
-50
- C1 -
1OYW
1
RECQ_ECOLI
A:
[8-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
E
S
G
A
K
Q
V
--
L
Q
E
T
F
G
--------------
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
------
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
---------
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
----
G
-
V
A
A
A
C
L
N
S
T
Q
T
R
E
Q
Q
L
E
V
M
T
G
C
R
T
G
Q
I
R
L
L
Y
I
A
P
E
R
L
M
L
------
D
N
F
L
E
H
L
A
H
W
N
P
V
L
L
A
V
D
E
A
H
C
I
S
Q
WGH
D
F
------
R
P
E
Y
A
A
LG
Q
L
R
Q
R
F
P
T
L
P
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
GL
N
D
P
L
I
-
Q
--
I
S
--
S
F
D
R
P
N
I
R
Y
M
L
M
E
K
----
F
K
------------
P
L
D
Q
L
M
R
Y
--
V
Q
E
Q
R
G
K
S
G
I
I
Y
C
N
S
R
A
-----------------------
K
V
E
D
T
A
A
R
L
Q
S
-----
K
----
G
I
S
A
A
A
Y
H
A
G
-------
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
----------------
R
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
----------------
N
I
E
S
Y
Y
-
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------