@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0219: (2016-03-13 )
MDDTEKRVHKYIEKHDLIRSDDKLLVAVSGGPDSLALLHFLWNSNLVPKEAISVAHLNHQLRENAAKEQRVVETFCERQGIPFYIEEVDIKSRAQSLQKGLEETARIVRYDFFEKVMAEKNINKLVLAHHADDQIETILMRLVRGSASIGWSGIQPKRELKGGQAIRPFLPITKAEIIDYAQKHELAYEIDESNTSQEYTRNRYRAQLLPFLKQENPAVYSHFERFSEETSEDFQFLEALASDLLKKNLIKNGKQTTLLLSSFKNEANPLQRRAIHLLLRYLYNEDASFITVNHIYQIIQMIQSDNPSSSIDLPNKLIANRAYDKLHFQFGEREAPSEFYHQLELNDRIELDNKASIRLKLKSSVVQTNGLNGMLLDAEEITLPLIVRNRVNGDRMTMKGQAGSKKLKDIFIDAKIPRQERDKLPVITDYTGKILWVPGVKKSAYDREFSRSKKQYIIRYTRNIGGNESMHNDIQKVLISEDELQEKIRELGRELTTEYEGRNPLVVGVLKGATPFMTDLLKRVDTYLEMDFMDVSSYGNGTVSSGEVKIIKDLNASVEGRDVLVIEDIIDSGRTLSYLVDLIKYRKAKSVKLVTLLDKPAGRNVEIEADYVGFVVPNEFVVGYGLDYAERYRNLPYIGILKPEIYSE
Atome Classification :
(91 SA)
.........10........20........30........40........50........60...-.....-70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360..-..-....-370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500-----..------...-.-...510.......520..---..---.---------.------------.530.......540.......550-.......560.......570.......580.......590.......600.-..-....610.......-620.......630.......640......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
D
T
E
K
R
V
H
K
Y
I
E
K
H
DLIRSD
D
K
L
L
V
A
VSGGP
D
S
L
A
L
L
H
F
L
WNSNLV
P
K
E
A
I
S
V
A
H
L
N
H
Q
L
R
E
N
-
A
A
K
E
Q
-
R
V
V
E
T
F
C
ERQGI
P
F
Y
I
EEV
D
I
K
S
R
A
Q
S
L
Q
K
G
L
E
E
T
A
R
I
V
R
Y
D
F
F
E
K
V
M
A
EKNI
N
K
L
V
L
AHHAD
D
Q
I
E
T
I
L
M
R
L
V
RGSASIGWSGIQ
P
K
R
ELKGGQAIRPFLPI
T
K
A
E
I
I
D
Y
A
Q
K
H
E
L
A
Y
EIDESNT
S
Q
E
Y
T
R
N
R
Y
R
A
Q
L
L
P
F
L
KQEN
P
A
V
Y
S
H
F
E
R
F
S
E
E
T
S
E
D
F
Q
F
L
E
A
L
A
S
D
L
L
K
K
N
L
IKNGK
Q
T
T
L
L
L
S
S
FKNEAN
P
L
Q
R
R
A
I
H
L
L
L
R
Y
L
YNEDA
S
F
I
T
V
N
H
I
Y
Q
I
I
Q
M
I
QSDNPSSSIDL
P
N
K
L
I
A
NRAY
D
K
L
H
F
QFGERE
A
P
S
E
F
Y
H
QLELND
R
I
ELDNK
A
S
I
R
L
K
L
-KS-
S
V
-VQTN-GLN
G
M
L
LDAEE
I
T
L
P
L
I
V
RNRVNGD
R
M
T
MKGQAGSK
K
L
K
D
I
F
IDAKI
P
R
Q
ERDKL
P
V
ITDYT
G
K
I
L
WVPGVKKS
A
Y
D
R
E
F
S
RS
K
K
Q
Y
I
I
R
Y
TRNIGGN
E
S
M
H
N
D
I
Q
K
V
LI
S
E
D
E
L
Q
E
K
I
R
E
L
G
R
E
L
T
T
EYE-------GR------N
P
L
-
V
-
V
G
VLKGA
T
P
F
M
T
D
L
L
K
R
V
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
DVSSYGNGTVSSG
E
V
K
I
I
K-DLNASVEG
R
D
V
L
V
I
E
D
I
IDSG
R
T
L
S
Y
L
V
D
L
I
K
Y
RKAK
S
V
K
L
V
T
L
LDKPAGR-
N
V
-
E
I
E
A
D
Y
V
G
F
VVPN
E
-
F
V
VGYG
L
D
Y
A
E
R
YRNL
P
Y
I
G
IL
K
P
E
IYSE
1
PsiBlast_PDB
80.54
39%
-79
- C1 -
3A2K
-
TILS_GEOKA
A:
[4-456]
------
K
V
R
A
F
I
H
R
H
Q
L
L
S
E
G
A
A
V
I
V
G
V
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G
G
P
D
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L
A
L
L
H
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F
L
S
L
R
D
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W
K
L
Q
V
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A
H
V
D
H
M
F
R
G
R
-
E
S
E
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E
M
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R
I
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Q
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Q
R
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A
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L
G
A
Q
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A
A
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F
A
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M
E
K
H
Q
A
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V
A
V
G
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G
D
D
Q
V
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I
L
M
R
L
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R
G
S
T
S
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G
Y
A
G
I
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K
R
P
F
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G
G
Y
L
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A
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A
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I
E
A
Y
C
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Q
M
G
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K
D
D
Y
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N
R
F
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L
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P
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L
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L
A
A
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A
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L
Q
L
L
L
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L
Y
G
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H
I
G
H
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C
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P
K
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L
K
V
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S
Y
D
R
C
L
F
T
F
D
A
E
S
G
E
K
G
Y
W
F
E
L
P
V
P
A
L
L
P
L
P
N
G
Y
A
I
I
S
E
F
-
G
E
-
H
Y
-
P
R
K
Q
A
G
N
D
W
F
V
V
D
P
A
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V
S
L
P
L
R
V
R
T
R
R
R
G
D
R
M
V
L
K
G
T
G
G
T
K
K
L
K
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F
I
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A
K
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W
P
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A
D
G
R
I
L
W
V
P
G
L
K
K
S
A
F
E
A
Q
-
N
R
G
Q
A
R
Y
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
79.93
39%
-75
* C1 *
3A2K
-
TILS_GEOKA
A:
[2-457]
----
I
D
K
V
R
A
F
I
H
R
H
Q
L
L
S
E
G
A
A
V
I
V
G
V
S
G
G
P
D
S
L
A
L
L
H
V
F
L
S
L
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D
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W
K
L
Q
V
I
A
A
H
V
D
H
M
F
R
G
R
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S
E
E
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M
-
E
F
V
K
R
F
C
V
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R
R
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C
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A
Q
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P
A
F
Q
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S
A
G
L
G
A
Q
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A
A
R
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C
R
Y
R
F
F
A
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L
M
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K
H
Q
A
G
Y
V
A
V
G
H
H
G
D
D
Q
V
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T
I
L
M
R
L
V
R
G
S
T
S
K
G
Y
A
G
I
P
V
K
R
P
F
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G
G
Y
L
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P
F
L
A
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I
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C
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P
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Y
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M
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L
Q
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L
L
L
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Y
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L
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K
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K
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Y
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L
F
T
F
D
A
E
S
G
E
K
G
Y
W
F
E
L
P
V
P
A
L
--
L
P
L
P
N
G
Y
A
I
I
S
E
F
G
E
H
Y
P
R
K
Q
A
-
G
N
D
W
F
V
V
D
P
A
S
V
S
L
P
L
R
V
R
T
R
R
R
G
D
R
M
V
L
K
G
T
G
G
T
K
K
L
K
E
I
F
I
E
A
K
I
P
R
M
E
R
D
R
W
P
I
V
E
D
A
D
G
R
I
L
W
V
P
G
L
K
K
S
A
F
E
A
Q
N
R
G
Q
A
R
Y
I
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
73.07
70%
-111
- C2 -
3HVU
2
?
A:
[19-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
S
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
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G
R
D
I
L
I
V
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I
I
D
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G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
23
PsiBlast_CBE
72.95
71%
-117
- C2 -
3KB8
7
?
B:
[23-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
2
PsiBlast_PDB
72.93
71%
-117
- C2 -
3H83
5
?
A:
[23-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
3
PsiBlast_PDB
72.60
71%
-111
- C2 -
3HVU
2
?
A:
[23-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
25
PsiBlast_CBE
71.92
71%
-112
- C2 -
3HVU
2
?
C:
[23-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
4
PsiBlast_PDB
71.82
71%
-119
- C2 -
3KB8
8
?
A:
[23-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
29
PsiBlast_CBE
71.72
71%
-111
- C2 -
3H83
4
?
B:
[23-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
26
PsiBlast_CBE
71.59
71%
-113
- C2 -
3HVU
2
?
B:
[23-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
21
PsiBlast_CBE
71.34
71%
-109
- C2 -
3KB8
4
?
D:
[24-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
24
PsiBlast_CBE
71.24
71%
-109
- C2 -
3HVU
2
?
D:
[23-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
27
PsiBlast_CBE
71.20
71%
-110
- C2 -
3H83
3
?
D:
[24-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
28
PsiBlast_CBE
70.78
71%
-109
- C2 -
3H83
3
?
C:
[24-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
22
PsiBlast_CBE
70.16
71%
-108
- C2 -
3KB8
4
?
C:
[24-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
M
N
Q
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
T
------
V
P
L
-
A
-
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
T
---
Y
---------
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
-
K
V
-
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
-
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
112
HHSearch
69.18
53%
-113
- C2 -
2GEB
2
?
A:
[4-184]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
P
S
P
M
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
K
------
D
L
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
L
---
P
---------
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
-
E
A
-
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
-
F
V
V
G
Y
G
I
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
6
PsiBlast_PDB
68.61
56%
-115
- C2 -
4RQB
6
?
A:
[5-185]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
V
M
H
N
D
L
K
E
V
L
L
T
E
E
D
I
Q
N
I
C
K
E
L
G
A
Q
L
T
K
D
Y
Q
-------
G
K
------
P
L
V
-
C
-
V
G
I
L
K
G
S
A
M
F
M
S
D
L
I
K
R
I
---
D
T
---
H
---------
L
------------
S
I
D
F
M
D
V
S
S
Y
H
G
G
T
E
S
T
G
E
V
Q
I
I
K
-
D
L
G
S
S
I
E
N
K
D
V
L
I
I
E
D
I
L
E
T
G
T
T
L
K
S
I
T
E
L
L
Q
S
R
K
V
N
S
L
E
I
V
T
L
L
D
K
P
N
R
R
-
K
A
-
D
I
E
A
K
Y
V
G
K
K
I
P
D
E
-
F
V
V
G
Y
G
L
D
Y
R
E
L
Y
R
N
L
P
Y
I
G
T
L
K
P
E
V
Y
S
-
113
HHSearch
68.48
54%
-110
- C2 -
1YFZ
4
?
A:
[27-204]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
M
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
K
------
D
L
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
L
---
P
---------
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
-
E
A
-
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
-
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
5
PsiBlast_PDB
68.45
56%
-115
- C2 -
4RQA
7
?
A:
[5-184]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
V
M
H
N
D
L
K
E
V
L
L
T
E
E
D
I
Q
N
I
C
K
E
L
G
A
Q
L
T
K
D
Y
Q
-------
G
K
------
P
L
V
-
C
-
V
G
I
L
K
G
S
A
M
F
M
S
D
L
I
K
R
I
---
D
T
---
H
---------
L
------------
S
I
D
F
M
D
V
S
S
Y
-----
S
T
G
E
V
Q
I
I
K
-
D
L
G
S
S
I
E
N
K
D
V
L
I
I
E
D
I
L
E
T
G
T
T
L
K
S
I
T
E
L
L
Q
S
R
K
V
N
S
L
E
I
V
T
L
L
D
K
P
N
R
R
-
K
A
-
D
I
E
A
K
Y
V
G
K
K
I
P
D
E
-
F
V
V
G
Y
G
L
D
Y
R
E
L
Y
R
N
L
P
Y
I
G
T
L
K
P
E
V
Y
--
9
PsiBlast_PDB
68.35
53%
-114
- C2 -
2GEB
2
?
A:
[7-184]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
M
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
K
------
D
L
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
L
---
P
---------
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
-
E
A
-
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
-
F
V
V
G
Y
G
I
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
55
PsiBlast_CBE
68.32
42%
-108
- C2 -
1P18
4
?
B:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
NVP------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
8
PsiBlast_PDB
68.08
52%
-110
- C2 -
1YFZ
4
?
A:
[27-204]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
M
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
K
------
D
L
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
L
---
P
---------
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
-
E
A
-
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
-
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
30
PsiBlast_CBE
67.70
52%
-111
- C2 -
1YFZ
4
?
B:
[28-204]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
D
I
E
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
K
------
D
L
V
-
L
-
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
L
---
P
---------
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
-
E
A
-
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
-
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
47
PsiBlast_CBE
67.67
42%
-109
- C2 -
1TC2
4
?
B:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
81
PsiBlast_CBE
67.28
42%
-109
- C2 -
1I0L
4
?
B:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
NVP------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
N
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
85
PsiBlast_CBE
67.24
42%
-110
- C2 -
1I13
4
?
B:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
NVP------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
A
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
58
PsiBlast_CBE
67.19
42%
-110
- C2 -
1P17
1
?
C:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
---
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
66
PsiBlast_CBE
66.85
46%
-114
- C2 -
4RHX
3
?
C:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
L
S
A
T
T
-
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
--
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
52
PsiBlast_CBE
66.83
42%
-108
- C2 -
1P19
1
?
A:
[9-190]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
--
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
--
62
PsiBlast_CBE
66.77
46%
-113
- C2 -
4RHY
3
?
C:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ETT----
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
------
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
64
PsiBlast_CBE
66.66
46%
-113
- C2 -
4RHY
3
?
A:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E------
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
79
PsiBlast_CBE
66.59
42%
-110
- C2 -
1I14
4
?
B:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
NVP------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
E
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
42
PsiBlast_CBE
66.40
47%
-104
- C2 -
4QYI
4
?
C:
[6-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
E
------
E
I
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
N
---
D
---------
V
------------
T
I
D
F
I
S
A
S
S
Y
G
N
Q
T
E
T
T
G
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
-
K
V
-
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
-
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
---------
80
PsiBlast_CBE
66.39
42%
-108
- C2 -
1I14
4
?
A:
[9-191]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
E
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
63
PsiBlast_CBE
66.33
46%
-112
- C2 -
4RHY
3
?
B:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-------
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
------
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
83
PsiBlast_CBE
66.27
42%
-107
- C2 -
1I0I
4
?
B:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
NVP------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
Q
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
53
PsiBlast_CBE
66.15
42%
-107
- C2 -
1TC1
2
?
B:
[8-189]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
--
84
PsiBlast_CBE
66.08
42%
-109
- C2 -
1I0I
4
?
A:
[9-191]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
Q
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
86
PsiBlast_CBE
66.05
42%
-113
- C2 -
1I13
4
?
A:
[9-191]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
A
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
82
PsiBlast_CBE
65.98
42%
-106
- C2 -
1I0L
3
?
A:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
N
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
60
PsiBlast_CBE
65.74
42%
-111
- C2 -
1P17
1
?
A:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
G
L
R
P
YV
N
P
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
---
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
68
PsiBlast_CBE
65.68
46%
-113
- C2 -
4RHX
3
?
A:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ELSATT-
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
----
S
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
56
PsiBlast_CBE
65.53
42%
-109
- C2 -
1P18
4
?
A:
[9-191]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
59
PsiBlast_CBE
65.51
42%
-106
- C2 -
1P17
1
?
B:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
------
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
74
PsiBlast_CBE
65.44
46%
-108
- C2 -
4RHU
2
?
A:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ETT----
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
------
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
50
PsiBlast_CBE
65.44
42%
-113
- C2 -
1P19
1
?
C:
[9-190]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
----
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
--
12
PsiBlast_PDB
65.40
47%
-111
- C2 -
3O7M
4
?
A:
[5-173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
E
------
E
I
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
N
---
D
---------
V
------------
T
I
D
F
I
S
A
S
S
Y
G
-------
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
-
K
V
-
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
-
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
---------
32
PsiBlast_CBE
65.35
47%
-113
- C2 -
3O7M
5
?
D:
[5-173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
E
------
E
I
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
N
---
D
---------
V
------------
T
I
D
F
I
S
A
S
S
Y
--------
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
-
K
V
-
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
-
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
---------
14
PsiBlast_PDB
65.35
48%
-108
- C2 -
1HGX
1
HGXR_TRIFO
A:
[7-179]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
D
L
E
R
V
L
Y
N
Q
D
D
I
Q
K
R
I
R
E
L
A
A
E
L
T
E
F
Y
E
-------
D
K
------
N
P
V
-
M
-
I
C
V
L
T
G
A
V
F
F
Y
T
D
L
L
K
H
L
---
D
F
---
Q
---------
L
------------
E
P
D
Y
I
I
C
S
S
----------
L
T
I
S
K
-
D
L
K
T
N
I
E
G
R
H
V
L
V
V
E
D
I
I
D
T
G
L
T
M
Y
Q
L
L
N
N
L
Q
M
R
K
P
A
S
L
K
V
C
T
L
C
D
K
D
I
G
K
-
K
A
Y
D
V
P
I
D
Y
C
G
F
V
V
E
N
R
-
Y
I
I
G
Y
G
F
D
F
H
N
K
Y
R
N
L
P
V
I
G
I
L
K
E
-----
110
HHSearch
65.31
47%
-112
- C2 -
1HGX
1
HGXR_TRIFO
A:
[7-179]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
D
L
E
R
V
L
Y
N
Q
D
D
I
Q
K
R
I
R
E
L
A
A
E
L
T
E
F
Y
E
-------
D
K
------
N
P
V
-
M
-
I
C
V
L
T
G
A
V
F
F
Y
T
D
L
L
K
H
L
---
D
F
---
Q
---------
L
------------
E
P
D
Y
I
I
C
S
S
----------
L
T
I
S
K
-
D
L
K
T
N
I
E
G
R
H
V
L
V
V
E
D
I
I
D
T
G
L
T
M
Y
Q
L
L
N
N
L
Q
M
R
K
P
A
S
L
K
V
C
T
L
C
D
K
D
I
G
K
K
A
Y
-
D
V
P
I
D
Y
C
G
F
V
V
E
N
R
-
Y
I
I
G
Y
G
F
D
F
H
N
K
Y
R
N
L
P
V
I
G
I
L
K
E
-----
57
PsiBlast_CBE
65.25
42%
-110
- C2 -
1P17
1
?
D:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
NVP------
V
------------
R
M
E
F
I
C
V
S
S
Y
---------
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
111
HHSearch
65.16
41%
-116
- C2 -
1TC1
2
?
A:
[5-187]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
GKGLRPY
V
N
------
P
L
V
-
L
-
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
F
N
V
P
---------
V
------------
R
M
E
F
I
C
V
S
S
Y
---------
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
----
48
PsiBlast_CBE
65.15
42%
-111
- C2 -
1TC2
4
?
A:
[9-190]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
--
61
PsiBlast_CBE
65.06
46%
-110
- C2 -
4RHY
3
?
D:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ATT----
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
----
S
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
33
PsiBlast_CBE
64.97
47%
-113
- C2 -
3O7M
2
?
C:
[6-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
E
------
E
I
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
N
---
D
---------
V
------------
T
I
D
F
I
S
A
S
S
Y
G
-------
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
-
K
V
-
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
-
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
---------
69
PsiBlast_CBE
64.89
46%
-114
- C2 -
4RHU
3
?
F:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-------
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
125
Fugue
64.83
48%
-107
- C2 -
1HGX
1
HGXR_TRIFO
A:
[7-179]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
D
L
E
R
V
L
Y
N
Q
D
D
I
Q
K
R
I
R
E
L
A
A
E
L
T
E
F
Y
E
-------
D
K
------
N
P
V
-
M
-
I
C
V
L
T
G
A
V
F
F
Y
T
D
L
L
K
H
L
---
D
-----
F
Q
-------
L
------------
E
P
D
Y
I
I
C
S
S
-----
L
T
I
S
K
------
D
L
K
T
N
I
E
G
R
H
V
L
V
V
E
D
I
I
D
T
G
L
T
M
Y
Q
L
L
N
N
L
Q
M
R
K
P
A
S
L
K
V
C
T
L
C
D
K
D
I
G
K
-
K
A
Y
D
V
P
I
D
Y
C
G
F
V
V
E
N
-
R
Y
I
I
G
Y
G
F
D
F
H
N
K
Y
R
N
L
P
V
I
G
I
L
K
E
-----
43
PsiBlast_CBE
64.83
47%
-104
- C2 -
4QYI
4
?
B:
[6-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
I
K
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
E
------
E
I
V
-
V
-
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
N
---
D
---------
V
------------
T
I
D
F
I
S
A
S
S
Y
G
N
Q
T
E
T
T
G
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
-
K
V
-
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
-
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
---------
72
PsiBlast_CBE
64.47
46%
-109
- C2 -
4RHU
2
?
C:
[20-198]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ELSATT-
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
----
73
PsiBlast_CBE
64.44
46%
-110
- C2 -
4RHU
3
?
B:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ELSATT-
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
----
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
67
PsiBlast_CBE
64.41
46%
-117
- C2 -
4RHX
3
?
B:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
SATT---
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
78
PsiBlast_CBE
64.23
46%
-113
- C2 -
4RHT
4
?
A:
[21-198]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-------
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
------
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
----
45
PsiBlast_CBE
64.14
47%
-121
- C2 -
3ACD
3
?
A:
[12-179]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
I
S
A
E
A
I
K
K
R
V
E
E
L
G
G
E
I
A
R
D
Y
Q
-------
G
K
------
T
P
H
-
L
-
I
C
V
L
N
G
A
F
I
F
M
A
D
L
V
R
A
I
---
P
L
---
P
---------
L
------------
T
M
D
F
I
A
I
S
------------
E
L
L
K
-
D
L
R
L
P
I
H
G
R
D
V
I
V
V
E
D
I
V
D
T
G
L
T
L
S
Y
L
L
D
Y
L
E
A
R
K
P
A
S
V
R
V
A
A
L
L
S
K
P
S
R
R
-
Q
V
-
E
V
P
I
H
Y
L
G
F
E
I
E
D
A
-
Y
V
Y
G
Y
G
L
D
R
A
Q
F
D
R
N
L
P
F
I
T
S
I
R
P
E
----
37
PsiBlast_CBE
64.03
48%
-113
- C2 -
1G9T
1
HPRT_ECOLI
B:
[10-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
DS-----
G
S
------
D
M
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
V
---
S
---------
H
------------
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
-
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
-
E
V
-
N
V
P
V
E
F
I
G
F
S
I
P
D
E
-
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
---------
77
PsiBlast_CBE
63.74
46%
-114
- C2 -
4RHT
4
?
B:
[20-199]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E-------
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
---
49
PsiBlast_CBE
63.49
42%
-111
- C2 -
1P19
1
?
D:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
NVP------
V
------------
R
M
E
F
I
C
V
S
----------
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
106
HHSearch
63.19
44%
-113
- C2 -
3ACD
3
?
A:
[4-179]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
T
P
G
N
G
P
V
Q
I
S
A
E
A
I
K
K
R
V
E
E
L
G
G
E
I
A
R
D
Y
Q
-------
G
K
------
T
P
H
-
L
-
I
C
V
L
N
G
A
F
I
F
M
A
D
L
V
R
A
I
---
P
L
---
P
---------
L
------------
T
M
D
F
I
A
I
S
------------
E
L
L
K
-
D
L
R
L
P
I
H
G
R
D
V
I
V
V
E
D
I
V
D
T
G
L
T
L
S
Y
L
L
D
Y
L
E
A
R
K
P
A
S
V
R
V
A
A
L
L
S
K
P
S
R
R
-
Q
V
-
E
V
P
I
H
Y
L
G
F
E
I
E
D
A
-
Y
V
Y
G
Y
G
L
D
R
A
Q
F
D
R
N
L
P
F
I
T
S
I
R
P
E
----
54
PsiBlast_CBE
63.04
42%
-111
- C2 -
1TC1
2
?
A:
[8-187]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
S
Y
---------
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
----
51
PsiBlast_CBE
62.65
42%
-104
- C2 -
1P19
1
?
B:
[9-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
K
GLRPYV
N
P
L
-
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
D
---
F
N
V
P
------
V
------------
R
M
E
F
I
C
V
S
------------
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
-
R
V
-
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
-
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
E
46
PsiBlast_CBE
62.62
47%
-119
- C2 -
3ACC
3
?
A:
[12-179]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
I
S
A
E
A
I
K
K
R
V
E
E
L
G
G
E
I
A
R
D
Y
Q
-------
G
K
------
T
P
H
-
L
-
I
C
V
L
N
G
A
F
I
F
M
A
D
L
V
R
A
I
---
P
L
---
P
---------
L
------------
T
M
D
F
I
A
I
S
S
Y
-----------
L
L
K
-
D
L
R
L
P
I
H
G
R
D
V
I
V
V
E
D
I
V
D
T
G
L
T
L
S
Y
L
L
D
Y
L
E
A
R
K
P
A
S
V
R
V
A
A
L
L
S
K
P
S
R
R
-
Q
V
-
E
V
P
I
H
Y
L
G
F
E
I
E
D
A
-
Y
V
Y
G
Y
G
L
D
R
A
Q
F
D
R
N
L
P
F
I
T
S
I
R
P
E
----
65
PsiBlast_CBE
62.48
46%
-109
- C2 -
4RHX
3
?
D:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ELSATT-
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
71
PsiBlast_CBE
62.46
46%
-107
- C2 -
4RHU
2
?
D:
[20-198]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
EATT---
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
---------
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
----
76
PsiBlast_CBE
62.44
46%
-103
- C2 -
4RHT
4
?
C:
[23-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
TT-----
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
--
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
-------
70
PsiBlast_CBE
61.83
46%
-111
- C2 -
4RHU
2
?
E:
[20-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
T------
G
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
------------
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
H
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
16
PsiBlast_PDB
61.60
48%
-113
- C2 -
1G9T
1
HPRT_ECOLI
A:
[10-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
DS-----
G
S
------
D
M
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
V
---
S
---------
H
------------
E
V
D
F
M
T
A
S
---------
R
D
L
K
I
L
K
-
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
-
E
V
-
N
V
P
V
E
F
I
G
F
S
I
P
D
E
-
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
---------
38
PsiBlast_CBE
61.44
48%
-110
- C2 -
1G9S
1
HPRT_ECOLI
B:
[10-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
DS-----
G
S
------
D
M
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
V
---
S
---------
H
------------
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
-
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
-
E
V
-
N
V
P
V
E
F
I
G
F
S
I
P
D
E
-
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
---------
75
PsiBlast_CBE
61.13
46%
-109
- C2 -
4RHT
4
?
D:
[21-197]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
K
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
---------
Q
------
D
L
L
-
L
-
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
V
---
P
---------
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
----
S
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
----
A
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
-
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
-----
109
HHSearch
60.95
30%
-100
- C2 -
3OZF
4
?
A:
[49-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
M
I
P
A
H
Y
K
K
Y
L
T
K
V
L
V
P
N
G
V
I
K
N
R
I
E
K
L
A
Y
D
I
K
K
V
Y
N
-------
N
E
------
E
F
H
-
I
-
L
C
L
L
K
G
S
R
G
F
F
T
A
L
L
K
H
L
---
S
R
---
I
---------
H
N
Y
S
AVETSKPL
F
G
E
H
Y
V
R
V
K
S
Y
C
N
D
Q
-
S
T
G
T
L
E
I
V
S
-
E
D
L
S
C
L
K
G
K
H
V
L
I
V
E
D
I
I
D
T
G
K
T
L
V
K
F
C
E
Y
L
K
K
F
E
I
K
T
V
A
I
A
C
L
F
I
K
R
T
P
L
-
W
N
-
G
F
K
A
D
F
V
G
F
S
I
P
D
H
-
F
V
V
G
Y
S
L
D
Y
N
E
I
F
R
D
L
D
H
C
C
L
V
N
D
E
G
K
K
-
90
PsiBlast_CBE
59.97
36%
-125
- C2 -
1PZM
1
?
A:
[25-202]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
DFHLT--
A
D
------
N
P
L
Y
L
-
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
A
D
E
G
V
---
P
---------
V
------------
K
V
E
F
I
C
A
S
-------------
M
L
L
-
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
-
K
V
-
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
-
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
E
----
15
PsiBlast_PDB
59.72
48%
-113
- C2 -
1G9S
1
HPRT_ECOLI
A:
[10-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
DS-----
G
S
------
D
M
V
-
L
-
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
V
---
S
---------
H
------------
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
-
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
-
E
V
-
N
V
P
V
E
F
I
G
F
S
I
P
D
E
-
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
---------
108
HHSearch
59.25
34%
-115
- C2 -
1PZM
1
?
A:
[20-202]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
M
S
A
R
T
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
DFHLTA-
D
N
------
P
L
Y
-
L
-
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
---
A
D
E
G
V
P
---------
V
------------
K
V
E
F
I
C
A
S
-------------
M
L
L
-
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
-
K
V
-
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
-
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
E
----
94
PsiBlast_CBE
58.68
34%
-110
- C2 -
4RAQ
3
HPRT_HUMAN
A:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
N
SD
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
S
-----------------
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
S
V
-
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------
99
PsiBlast_CBE
58.46
34%
-112
- C2 -
4RAN
2
HPRT_HUMAN
D:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
N
SDR
S
I
P
M
------------
T
V
D
F
I
R
L
--------------
V
I
G
G-----
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
S
V
-
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------
95
PsiBlast_CBE
57.69
34%
-107
- C2 -
4RAO
3
HPRT_HUMAN
D:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
N
SD
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
S
Y
--------
D
I
K
V
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
S
V
-
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------
98
PsiBlast_CBE
57.62
34%
-112
- C2 -
4RAO
3
HPRT_HUMAN
A:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
N
SR
S
I
P
-
M
------------
T
V
D
F
I
R
L
K
-------------------
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
S
V
-
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------
89
PsiBlast_CBE
57.19
36%
-130
- C2 -
1PZM
1
?
B:
[25-201]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
DFHLT--
A
D
------
N
P
L
Y
L
-
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
A
D
E
G
V
---
P
---------
V
------------
K
V
E
F
I
C
A
------------
V
R
M
L
L
-
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
-
K
V
-
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
-
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
-----
97
PsiBlast_CBE
56.78
34%
-110
- C2 -
4RAO
3
HPRT_HUMAN
B:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
NSDRSIP
M
------------
T
V
D
F
I
R
L
K
-------------
V
I
G
G
D
D
--
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
S
---
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------
96
PsiBlast_CBE
56.40
34%
-106
- C2 -
4RAO
3
HPRT_HUMAN
C:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
N
S
D
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
------------
K
V
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
S
V
-
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------
91
PsiBlast_CBE
55.38
34%
-111
- C2 -
4RAQ
3
HPRT_HUMAN
D:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
N
S
D
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
-------------
V
I
G
--
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
S
V
-
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------
92
PsiBlast_CBE
55.20
34%
-111
- C2 -
4RAQ
3
HPRT_HUMAN
C:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
N
S
D
R
S
I
P
M
------------
T
V
D
F
I
R
L
---------------
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
--
V
-
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------
100
PsiBlast_CBE
54.85
34%
-108
- C2 -
4RAN
2
HPRT_HUMAN
C:
[30-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
H
------
H
I
V
-
A
-
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
A
---
L
N
R
N
SD
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
-------------
V
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
S
V
-
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
-
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
C
V
I
-------