@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0224: (2016-03-13 )
LKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEEAVARALQMAEDGAAIIDVGGISTRPGFSEVTPDEELARIIPVIKAVRTKLPDIWISVDSWRAEVAEQAILAGADMINDQWGAKKEPKIAEVAAKYDVPICLMHNRENAQYDNFLEDVKKDLLESIAIAKAASVPDEHIILDPGFGFVKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPGDRMEGTGATTVYGFSKGCTITRVHDVLPIARMVRMTDAITGKLDITNL
Atome Classification :
(61 SA)
.........10..-......20........30-........40...-----.....50........60........70........80-....----.....90........100.......110.......120.......-130.....--..---140------.--------.--------.-------.----------------------------..------..150----.......-----160.......170.......---180..-.-....190......-----.----------------200.......210......---------.220------..------......230......--.240.......------250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LKK
W
K
R
D
H
L
G
M
V
M
-
G
I
LNVTPDSFSDGG
K
Y
M
Q
-
V
E
E
A
V
A
R
A
L
Q
MAE-----DG
A
A
I
I
D
VGGISTRPGFSEVT
P
D
E
E
L
A
R
I
I
P
V
I
K
A
V
--
R
TKL----P
D
I
W
I
S
V
D
S
W
R
A
E
V
A
E
Q
A
I
L
AGADMINDQWGAKKEP
K
I
A
E
V
A
A
KY-DV
P
I
C
L
M
H--NR---EN-------A--------
Q
--------
Y
-------
D
----------------------------
N
F
------
L
E
D
V
K
----
K
D
L
L
E
S
I
-----
A
I
A
KAASVPD
E
H
I
I
LDPGFG---FVKT
P
-
A
-
Q
N
L
E
V
L
R
R
I
D
E
I
V
-----
A
----------------
L
G
Y
E
V
LLGTSRK
S
T
I
G
L
V
L
---------GT-T------PG------DRMEGTGA
T
T
V
Y
GFS--KG
C
T
I
T
R
V
H
D
V
------
L
P
I
A
R
M
V
R
M
T
D
AITGKLDITNL
19
PsiBlast_PDB
92.75
59%
-105
- C8 -
3TYD
8
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
26
PsiBlast_CBE
91.52
59%
-106
- C8 -
4NHV
8
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
42
PsiBlast_CBE
91.44
59%
-105
- C8 -
3H2E
6
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
----
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
36
PsiBlast_CBE
91.11
59%
-108
- C8 -
3TYD
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
37
PsiBlast_CBE
90.49
59%
-103
- C8 -
3TYC
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
12
PsiBlast_PDB
90.34
59%
-97
- C8 -
3H2E
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
46
PsiBlast_CBE
90.16
59%
-104
- C8 -
1TX2
6
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
25
PsiBlast_CBE
90.15
59%
-93
- C8 -
4NIL
6
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
17
PsiBlast_PDB
90.10
59%
-101
- C8 -
3TYA
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
6
PsiBlast_PDB
89.90
59%
-100
- C8 -
3H21
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
5
PsiBlast_PDB
89.84
59%
-101
- C8 -
1TX2
6
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
13
PsiBlast_PDB
89.82
59%
-100
- C8 -
3H2F
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
33
PsiBlast_CBE
89.81
59%
-103
- C8 -
4D8Z
6
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
11
PsiBlast_PDB
89.79
59%
-105
- C8 -
3H2A
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
51
PsiBlast_CBE
89.70
59%
-99
- C8 -
3V5O
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
N
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
2
PsiBlast_PDB
89.64
59%
-102
- C8 -
1TWW
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
21
PsiBlast_CBE
89.60
59%
-103
- C8 -
4NL1
5
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
--
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
18
PsiBlast_PDB
89.59
59%
-101
- C8 -
3TYB
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
27
PsiBlast_CBE
89.53
59%
-92
- C8 -
4NHV
8
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
39
PsiBlast_CBE
89.52
59%
-103
- C8 -
3TYA
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
20
PsiBlast_PDB
89.40
59%
-100
- C8 -
3TYE
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
------
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------