@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0228: (2016-03-13 )
MSNENHEELNDQLIVRREKVDTLREEGIDPFGEKFIRSISPEEIETKFADKSKEELEEAAIEVSVAGRIMTKRVKGKVGFTHIQDRFHQLQIYIRKDAIGEDAYAVFKLADLGDIIGIKGTIFRTNTGELSVKATEFTLLSKSLRPLPDKYHGLKDVEQRYRQRYLDLITNEESQNRFVMRSKILKYTRDYMDNQGFLEVETPVLHTIAGGAAAKPFITHHNALDMELYLRIALELHLKRLIVGGMDKVYEIGRVFRNEGTSTRHNPEFTMLESYAAYEDYEDVMDLVEGLVSTVCKQVNGTTEITYGEYKVDLTPNWRRIHMADAVKEYVGVDFWNVTSDEEARELAKKHDVPVTEHMTYGHILNEFFETYVEEKLIQPTFVYGHPVEISPLAKKNKEDERFTDRFELFIVGREHANAFSELNDPIDQRERFEAQMKEREQGNDEAHGMDADFLEALEYGLPPTGGLGIGIDRLVMLLTDAPSIRDILLFPTMKHRD
Atome Classification :
(31 SA)
.........10........-20........30........40........50.........60........70.....-.-..80........90...--...-..--100..-.-....110.......120.......130.......140.......150.......160.......170.......180.......190.......200...-....210.......220--........230.......240.......250.......260........270......-.280.......290.......300......-------..310.......320.......330.-...--....-340-..----...------..350.....----..360.......370......---.380-.........390-.......400.....---------------------------------------..410.......420.......430.......440.......450.......460.......470.......480.......490......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNE
N
H
E
E
L
N
D
Q
L
I
V
R
R
E
K
-
V
D
T
L
R
E
EGI
D
P
F
G
E
K
F
I
R
SI
S
P
E
E
I
E
T
K
FAD-K
S
K
E
E
L
E
E
A
A
I
E
V
S
VA
G
R
I
M
T
K
R
VKG-K-VG
F
T
H
I
Q
D
R
F
H
Q
L
Q
I
Y
I
--
R
KD-AI--GEDA
Y
-
A
-
V
F
K
LADLGDIIGI
K
G
T
I
F
RTNTG
E
L
S
V
K
AT
E
F
T
L
L
S
K
SLRPL
P
D
KYH
G
L
K
D
V
E
Q
R
Y
R
Q
R
Y
L
D
L
ITNEESQ
N
R
F
V
M
R
S
K
I
L
K
Y
T
R
D
Y
MDNQG
F
L
E
VETP
V
L
-
H
TIAGGAAAK
P
F
ITHH---NAL
D
M
E
L
Y
L
R
I
A
L
E
L
H
L
K
R
L
I
VG
G
M
D
K
V
Y
E
I
G
R
V
F
RNEGT-STRHNP
E
F
T
M
L
E
S
Y
A
A
Y
-
E
D
Y
E
D
V
M
D
L
V
E
G
L
V
S
T
V
C
K
QVN-GT
T
E
I
T
Y-------G
E
Y
K
V
DLTPNW
R
R
I
H
M
A
D
A
V
K
E
Y
V-G-V
D
F
--WNVT-S
D
E
-
E
A
----
R
E
L
------
A
K
KHDVP
V
T
E
----
H
M
T
Y
G
H
I
L
N
E
F
F
E
T
Y
V
E
E
KLI---Q
P
---
T
F
VYGHPVEISP-LAKKNKE
D
E
R
FT
D
R
F
---------------------------------------
E
L
F
I
V
GREHA
N
A
F
S
ELNDP
I
D
Q
R
E
R
F
E
A
Q
M
K
E
R
EQGNDEAHGM
D
A
D
F
L
E
A
L
EYGLPPTGGL
G
I
G
I
D
R
L
V
M
L
LTDAPSI
R
D
I
L
L
FPTMKHRD
27
PsiBlast_CBE
98.57
70%
-89
- C7 -
3A74
5
SYK_GEOSE
D:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
24
PsiBlast_CBE
98.54
70%
-87
- C7 -
3E9H
2
SYK_GEOSE
D:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
29
PsiBlast_CBE
98.43
70%
-89
- C7 -
3A74
5
SYK_GEOSE
B:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
22
PsiBlast_CBE
98.06
70%
-89
- C7 -
3E9I
4
SYK_GEOSE
C:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
28
PsiBlast_CBE
97.99
70%
-88
- C7 -
3A74
5
SYK_GEOSE
C:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
3
PsiBlast_PDB
97.95
70%
-89
- C7 -
3A74
5
SYK_GEOSE
A:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
71
HHSearch
97.85
70%
-89
- C7 -
3A74
5
SYK_GEOSE
A:
[5-492]
--------
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
2
PsiBlast_PDB
97.82
70%
-87
- C7 -
3E9I
4
SYK_GEOSE
A:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
1
PsiBlast_PDB
97.64
70%
-89
- C7 -
3E9H
2
SYK_GEOSE
A:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
21
PsiBlast_CBE
97.58
70%
-89
- C7 -
3E9I
4
SYK_GEOSE
D:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
26
PsiBlast_CBE
97.36
70%
-87
- C7 -
3E9H
2
SYK_GEOSE
B:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
25
PsiBlast_CBE
97.17
70%
-89
- C7 -
3E9H
2
SYK_GEOSE
C:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
23
PsiBlast_CBE
96.04
70%
-86
- C7 -
3E9I
4
SYK_GEOSE
B:
[4-492]
-------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
-
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
-
D
V
--
G
E
Q
Q
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
-
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
-
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
-------
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
-
V
D
F
--
W
R
Q
M
-
S
D
E
-
E
A
----
R
E
L
------
A
K
E
H
G
V
E
V
A
P
----
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
---
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
---------------------------------------
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
--
60
Fugue
89.83
51%
-81
- C7 -
1LYL
1
SYK2_ECOLI
A:
[14-502]
--------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
-
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
-
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
-D
S
L
--
P
E
G
V
Y
-
N
D
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
-------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
-
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
---
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
-I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A-
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
-------
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
-
T
D
M
--
A
D
L
D
-
N
F
D
-
A
A
----
K
A
L
------
A
E
S
I
G
I
T
V
E
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
---
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
-P
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
---------------------------------------
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
--
30
PsiBlast_CBE
89.77
51%
-82
- C7 -
1LYL
1
SYK2_ECOLI
C:
[14-501]
--------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
-
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
-
S
L
--
P
E
G
V
Y
-
N
D
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
-
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
---
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
-
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
-------
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
-
P
E
T
D
M
--
A
D
L
D
-
N
F
D
-
A
A
----
K
A
L
------
A
E
S
I
G
I
T
V
E
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
---
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
---------------------------------------
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
---
31
PsiBlast_CBE
89.73
51%
-82
- C7 -
1LYL
1
SYK2_ECOLI
B:
[14-501]
--------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
-
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
-
S
L
--
P
E
G
V
Y
-
N
D
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
-
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
---
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
-
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
-------
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
-
P
E
T
D
M
--
A
D
L
D
-
N
F
D
-
A
A
----
K
A
L
------
A
E
S
I
G
I
T
V
E
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
---
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
---------------------------------------
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
---
9
PsiBlast_PDB
89.24
51%
-80
- C7 -
1BBU
1
SYK1_ECOLI
A:
[13-501]
-------
D
L
N
N
E
L
K
T
R
R
E
K
-
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
-
K
E
N
E
E
L
E
A
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
-
D
L
--
P
E
G
V
Y
-
N
E
Q
F
K
K
W
D
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
-
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
---
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
-
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
-
G
K
T
E
V
T
Y
-------
G
D
V
T
L
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
-
P
E
T
D
M
--
A
D
L
D
-
N
F
D
-
S
A
----
K
A
I
------
A
E
S
I
G
I
H
V
E
K
----
S
W
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
I
---
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
---------------------------------------
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
---
4
PsiBlast_PDB
89.02
51%
-80
- C7 -
1LYL
1
SYK2_ECOLI
A:
[14-501]
--------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
-
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
-
S
L
--
P
E
G
V
Y
-
N
D
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
-
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
---
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
-
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
-------
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
-
P
E
T
D
M
--
A
D
L
D
-
N
F
D
-
A
A
----
K
A
L
------
A
E
S
I
G
I
T
V
E
K
----
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
---
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
---------------------------------------
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
---