@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0258: (2016-03-13 )
LSGHSGHDVKYGRHRTRRSFARISEVLELPNLIEIQTASYQWFLDEGLREMFRDISPIEDFAGNLSLEFIDYDLGEPKYSVEESKNRDANYAAPLRVKLRLINKETGEVKDQEVFMGDFPLMTEMGTFIINGAERVIVSQLVRSPGVYFNGKLDKNGKKGFGSTVIPNRGAWLEYETDAKDVVHVRIDRTRKLPVTVLLRALGFGSDQEIIDLIGDNDYLRNTLEKDNTDNAEKALLEIYERLRPGEPPTVDNARSLLVSRFFDPKRYDLASVGRYKINKKLHLKNRLFNQTLAETLVDPETGEIIASKGDILDRRNLDQIIPNLENGVGFRTLRPTDGVMEDSVLVQSIKIYAPNDEEKEINIIGNAYIEENVKHITPSDIISSISYFFNLLHGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDMTTITPQQLINIRPVVASIKEFFGSSQLSQFMDQTNPLGELTHKRRLSALGPGGLTRERAGYEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSFAKVNKFGFIETPYRRVDPETNRVTDKIDYLTADEEDNYVVAQANSKLDEQGTFTEEEVMARFRSENLAVEKERIDYMDVSPKQVVSVATACIPFLENDDSNRALMGANMQRQAVPLMHPEAPFVGTGMEHVSAKDSGAAVTAKHDGIVEHVEAREIWVRRVSLVDGKEVTGGIDKYTLRKFVRSNQGTCYNQRPNVAEGDRVVKGEILGNGPSMDSGELALGRNVLVAFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEFESEARDTKLGPEEMTRDIPNVGEDALRDLDERGIIRVGAEVKDNDLLVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGGGGIVLDVKIFTREAGDELPPGVNQLVRVYIVQKRKIHEGDKMAGRHGNKGVISRILPEEDMPFMPDGTPVDIMLNPLGVPSRMNIGQVLELHLGMAARALGIHVATPVFDGANEEDVWSTVEEAGMARDAKTILYDGRSGEAFDNRISVGVMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTIKSDDVVGRVKTYEAIVKGESVPEPGVPESFKVLIKELQSLGMDVKMLSADEEEIEMRDMDDDDFTNQNDAFNIVQPENAAAEKTE
Atome Classification :
(46 SA)
.........10........20........30........40.....----------...50........60.---.......70........80........90........100-------...-------....110.......120.......130.......140.......150-.........160.....--..170.......180.......190.......200.......210.......220....-..-..230.......240.......-250.......260.......270.......280...---....290------------------........300.......310---.....------....320..-.....330------------....--....340.......350.....---.------.360...------------....370....--------...-----------------------380.......390....--.--..400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700..---.....710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......-890.....-.----------------------------------------------------------------------------------------------------.900.......910.......920.......930.......940.......950.......960.......970.......980...------------------------------------------------------....990.......1000--------------------------........-----------------------------.1010------------.....--------------...1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LSGHSGHDVKY
G
R
H
R
T
R
R
S
F
A
R
I
S
E
V
L
ELP
N
L
I
E
I
QTAS
Y
Q
W
F
L
D
E
----------
G
L
R
E
M
F
R
DIS
P
I
E
D
F
A---GN
L
S
L
E
F
I
DYDLGEPKYSVEESKNRDANYAA
P
L
R
V
K
L
R
L
I-------NKE-------TGEVKDQ
E
V
FMGDF
P
L
M
T
EM
G
T
F
I
ING
A
E
R
V
I
V
S
Q
L
V
RSPG
V
Y
FN---GKLDKNGKKGFGSTVIP--NRG
A
W
L
E
YETDAK
D
V
V
H
V
R
IDRTRKL
P
V
T
V
L
L
R
A
LGFG
S
D
Q
E
I
I
D
L
IGD
N
D
Y
L
-
R
N
T
L
E-KD-NTD
N
A
E
K
A
L
L
E
I
Y
E
R
LRPGEPP-TVD
N
A
R
S
L
L
V
S
RFFDPKRY
D
L
A
SVG
R
Y
K
IN
K
K
L
H
L
K
---
N
R
L
F
N
Q
-------------------
T
L
A
E
T
LVDPETG
E
I
IASKG-----DILDR------R
N
L
D
Q
I
I
P
N-LENGVG
F
-------------
R
TLR--PTDGVM
E
D
S
V
L
V
Q
S
I
K
I
YAPND---E------E
K
E
I
N
I
I
------------G
N
A
Y
I
E
ENVKH--------I
T
P
-----------------------
S
D
I
I
S
S
I
S
Y
F
F
N
L
L
HGV--G--DT
D
D
I
D
H
L
G
N
R
R
L
R
S
V
G
E
L
L
Q
N
Q
F
R
I
G
L
S
R
M
E
R
V
V
R
E
R
MSIQDMTTI
T
P
Q
Q
L
INI
R
P
V
V
A
S
I
K
E
F
F
G
S
S
Q
L
S
Q
F
M
DQTN
P
L
G
E
L
T
H
K
R
R
L
SALGPGGLTRERAGY
E
V
R
D
V
H
Y
S
HYGRMCPIETPEGPNI
G
L
I
N
S
L
S
S
F
A
K
VNKFGFIET
P
Y
RRVDPETNRVTDKI
D
Y
L
TADEED
N
Y
V
V
A
QANSKLDEQGTF
T
E
E
E
V
M
A
R
F
RSENLA
V
E
K
ERIDYMDV
S
P
K
Q
V
V
S
V
A
T
A
C
I
P
FLENDDSN
R
A
L
MGANMQRQAVPLMHPEAPFVGTGMEHVSAKDS
G
A
A
V
T
AKHD
G
I
V
E
H
V
E
A
R
E
I
W
V
R
R
VSLVDGKEV---TGG
I
D
K
Y
T
L
R
K
F
V
R
SNQGTCYNQRPNVAEG
D
R
V
V
K
G
E
I
LGNGPSMDSGELALGR
N
V
L
V
A
F
M
TWDGYNY
E
D
A
I
I
M
S
E
R
L
VKDDV
Y
T
S
I
H
I
E
E
F
E
S
EARDTKL
G
P
E
E
M
T
R
DIPNV
G
E
D
A
L
R
D
L
D
ER
G
I
I
R
VGAEVKDN
D
L
L
V
GKVTPK
G
V
T
E
L
T
A
E
E
R
L
L
H
A
I
F
G
E
K
A
R
E
VRDTSLRVPHGG
G
G
I
V
L
-
D
V
K
I
F
T
RE-A----------------------------------------------------------------------------------------------------GDELPP
G
V
N
Q
L
V
R
V
Y
I
V
Q
K
RKIHEGDKMAGRHG
N
K
G
V
I
S
R
ILPEEDMPFMPDG
T
P
V
D
I
M
LNPLGVPSRM
N
I
G
Q
V
L
E
L
H
L
G
M
A
A
R
A
L
G
------------------------------------------------------
I
H
VATPVFDGA
N
E
E
D
-----------------------------
V
W
S
T
V
E
E
A-----------------------------GMA--------------RD
A
K
T
--------------
I
L
YDGRSGEAFD
N
R
I
S
V
G
V
M
Y
M
I
K
L
A
H
M
VDDKLHARSTGP
Y
S
L
V
TQQPLGGKAQFGGQRFGE
M
E
V
W
A
L
EAYG
A
A
Y
T
L
Q
E
I
L
TIKSDDVVG
R
V
K
T
Y
E
A
I
VKGESVPEPGV
P
E
S
F
K
V
L
I
K
E
L
Q
SLGM
D
V
K
MLSA
D
E
E
EIEMRDMDDDDFTNQND
A
F
N
I
VQPENAAAEKTE
99
Fugue
84.95
53%
-57
- C5 -
3LU0
-
RPOB_ECOLI
C:
[8-1342]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
IYEREAP
E
G
T
-------
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
-
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
----------
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
G
K
V
Y
V
E
K
---
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
VPV
E
Y
I
A
G
K
-------------------
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
-----
M
E
L
S
L
------
D
L
L
A
K
L
S
Q
S
-
G
H
K
R
I
E
T
LFTNDLDHGPYIS
E
T
L
R
--
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
---
P
PTREAA
E
S
L
F
E
N
L
FFSEDRYDLSAV
G
R
M
K
F
N
R
S
L
L
R
EEIEGSGI
L
S
K
-----------------------
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
V
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
--
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
-
D
E
M
Y
P
G
---
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
VEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQ
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
DKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKG
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
-----------------------------
I
K
E
L
L
K
L
G
-----------------------------
D
L
P
--------------
T
S
G
Q
I
--------------
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
------------------------------------
80
PsiBlast_CBE
84.24
47%
-61
- C5 -
4MEX
1
RPOB_ECOLI
I:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
LEKDDVKLIEVPVEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
MELSL
D
L
L
A
K
LSQSGH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S------------
E
T
L
R
VD
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
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R
G
D
V
L
A
D
G
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S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
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K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
84.18
55%
-56
- C5 -
2A6H
1
RPOB_THET8
C:
[2-1112]
---------------
E
I
K
R
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVPPEKRENV
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
E
D
KGK
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
-------
T
G
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
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D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
T
---
P
D
P
A
R
--
P
G
R
Y
I
A
S
I
I
P
LP
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
K
-
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
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-
L
A
R
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L
G
A
Y
G
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L
V
Q
G
L
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D
-
E
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V
F
A
M
R
P
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E
A
L
I
R
L
F
T
L
L
R
P
G
D
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P
-
K
R
D
K
A
V
A
Y
V
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L
I
A
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P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
I
R
----------------------------------
L
S
---------------------------------------------------------------------------
G
R
T
L
A
R
--------------------
F
------------
E
D
-------
G
E
--------
F
K
D
-----------------------
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
PG
H
--
E
V
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M
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M
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S
L
T
P
A
K
L
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R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
--
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
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I
A
Q
A
N
T
P
L
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G
N
-
R
I
A
A
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R
V
V
A
R
R
K
G
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V
S
P
E
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F
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P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
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H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
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P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
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V
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D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
--------
E
---
D
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
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N
G
F
L
A
L
G
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N
V
L
V
A
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M
P
F
D
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Y
N
F
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D
A
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E
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L
L
K
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D
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Y
T
S
I
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I
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A
R
D
T
K
L
G
P
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R
I
T
R
D
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L
S
E
A
A
L
R
D
L
D
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E
G
V
V
R
I
G
A
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V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
-
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
IKELLAQAFEVYFGKRKGEGFGVDKREVE
V
L
R
R
A
E
K
L
-----------------------------
G
L
V
TPGKTPEEQLKELF
L
Q
G
K
V
--------------
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
----------------------------
81
PsiBlast_CBE
83.59
47%
-59
- C5 -
4MEX
1
RPOB_ECOLI
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
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P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
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K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
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R
Q
L
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D
DVK
L
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P
V
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V
V
A
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D
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L
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C
A
A
N
MELS
L
D
L
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L
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Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
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--
S
A
L
V
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Y
R
M
M
R
P
G
E
P
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T
R
------
E
A
A
E
S
L
F
------------
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N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
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V
D
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G
N
R
R
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A
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L
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K
V
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--
V
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L
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A
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N
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G
H
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F
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D
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V
G
A
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L
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F
L
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D
D
A
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A
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M
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A
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M
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L
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G
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A
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A
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A
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A
K
R
G
G
V
V
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V
D
A
S
R
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V
I
K
----
V
N
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D
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A
G
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N
L
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Y
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L
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E
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A
L
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K
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G
D
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V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
82.75
56%
-56
- C5 -
4G7H
2
RPOB_THET8
M:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
26
PsiBlast_CBE
82.73
56%
-57
- C5 -
4OIQ
3
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
79
PsiBlast_CBE
82.57
47%
-61
- C5 -
4XSX
1
?
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
L
E
K
D
DVK
L
I
E
V
P
VEYIAG
K
V
V
A
K
D
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S
T
G
E
L
I
C
A
A
N
M
E
L
S
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D
L
L
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K
L
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Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
R
V
D
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
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S
Q
L
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M
D
Q
N
N
P
L
S
E
I
T
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K
R
R
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A
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G
P
G
G
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R
A
G
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E
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Y
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I
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T
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P
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I
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N
S
L
S
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Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.54
56%
-54
- C5 -
4MQ9
2
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
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E
N
G
F
L
A
L
G
Q
N
V
L
V
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I
M
P
F
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G
Y
N
F
E
D
A
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V
I
S
E
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L
L
K
R
D
F
Y
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S
I
H
I
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Y
E
I
E
A
R
D
T
K
L
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R
I
T
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D
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H
L
S
E
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A
L
R
D
L
D
E
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G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
GKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
27
PsiBlast_CBE
82.45
56%
-56
- C5 -
4OIP
5
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
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G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
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Y
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S
N
Q
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A
L
D
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L
L
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N
G
F
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A
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N
V
L
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M
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Y
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L
L
K
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Y
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H
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Y
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A
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K
L
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P
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D
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H
L
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A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
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V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
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S
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T
P
E
E
R
L
L
R
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I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
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F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
17
PsiBlast_PDB
82.44
56%
-56
- C5 -
4G7H
2
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
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G
L
A
R
L
A
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G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
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F
F
S
R
S
Q
L
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F
K
D
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T
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P
L
S
S
L
R
H
K
R
R
I
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A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
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V
V
Y
M
T
A
T
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E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
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V
V
A
R
R
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V
I
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V
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F
M
D
V
S
P
K
Q
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F
S
V
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T
N
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I
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F
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D
A
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R
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L
M
G
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N
M
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Q
A
V
P
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I
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A
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A
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V
V
M
T
G
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R
V
V
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S
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A
A
L
Y
A
E
E
D
G
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V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
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V
R
K
G
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L
L
A
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N
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F
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L
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V
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M
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Y
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V
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L
L
K
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Y
T
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Y
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D
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L
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P
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A
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R
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L
D
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V
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I
G
A
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P
G
D
I
L
V
G
R
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F
K
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E
S
E
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T
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E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
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D
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R
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G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
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D
K
M
H
A
R
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P
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S
L
I
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Q
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P
L
G
G
K
A
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F
G
G
Q
R
F
G
E
M
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A
L
E
A
Y
G
A
A
H
T
L
Q
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M
L
T
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K
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I
E
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A
Y
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A
I
I
K
G
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P
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L
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Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
78
PsiBlast_CBE
82.40
47%
-62
- C5 -
4XSX
1
?
I:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
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L
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V
Q
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Q
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R
G
V
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Y
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A
P
L
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K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
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Y
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--
Y
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R
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A
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I
I
L
R
A
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N
Y
T
T
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Q
-
I
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D
L
F
----
F
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-
K
V
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D
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N
K
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M
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----
V
P
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R
L
R
-
G
E
T
A
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-----------------
F
D
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K
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A
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LEKDDVKLIEVPVEYIAGK
V
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A
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D
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T
L
F
T
N
D
L
D
H
G
P
Y
I
S------------
E
T
L
R
VD
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
82.36
47%
-59
- C5 -
4XSZ
1
?
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
L
E
K
D
DVK
L
I
E
V
P
VEYIAG
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
R
V
D
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
82.30
47%
-60
- C5 -
4KN7
1
RPOB_ECOLI
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEG
Q
Y
----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
L
E
K
D
DVK
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
R
V
D
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
82.24
47%
-59
- C5 -
4ZH4
1
?
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
L
E
K
D
DVK
L
I
E
V
P
VEYIAG
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
R
V
D
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.20
56%
-53
- C5 -
4G7O
3
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
GKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
67
PsiBlast_CBE
82.19
47%
-58
- C5 -
4YG2
1
RPOC_ECOLI
I:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
LEKDDVKLIEVPVEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
MELSL
D
L
L
A
K
LSQSGH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S------------
E
T
L
R
VD
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
82.18
47%
-58
- C5 -
4ZH3
1
?
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
L
E
K
D
DVK
L
I
E
V
P
VEYIAG
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
R
V
D
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
82.17
47%
-59
- C5 -
4XSY
1
?
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
L
E
K
D
DVK
L
I
E
V
P
VEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
R
V
D
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
82.16
47%
-57
- C5 -
4YFK
1
RPOB_ECO24
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
L
E
K
D
DVK
L
I
E
V
P
VEYIAG
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
R
V
D
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
82.14
47%
-59
- C5 -
4KN4
1
RPOB_ECOLI
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEG
Q
Y
----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
L
E
K
D
DVK
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
GH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
------------
E
T
L
R
V
D
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
V
G
R
M
K
F
N
R
S
L
LREEIEGSGILS
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
82.11
56%
-52
- C5 -
4G7O
3
RPOB_THET8
M:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
24
PsiBlast_CBE
82.09
56%
-57
- C5 -
4Q4Z
4
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
29
PsiBlast_CBE
82.02
56%
-57
- C5 -
4OIN
4
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
23
PsiBlast_CBE
81.82
56%
-55
- C5 -
4Q5S
4
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
19
PsiBlast_PDB
81.73
56%
-52
- C5 -
4G7Z
2
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
GK
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
66
PsiBlast_CBE
81.66
47%
-60
- C5 -
4YLN
1
RPOB_ECOLI
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
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P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
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A
N
G
K
V
Y
V
E
K
G
R
R
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T
---
A
R
H
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R
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LEKDDVKLIEVPVEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
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I
C
A
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N
MELSL
D
L
L
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LSQSGH
K
R
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T
L
F
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N
D
L
D
H
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P
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S------------
E
T
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VD
P
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D
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--
S
A
L
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R
M
M
R
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R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
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D
D
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H
L
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R
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A
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L
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L
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A
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G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.64
56%
-56
- C5 -
4OIR
4
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
28
PsiBlast_CBE
81.23
56%
-53
- C5 -
4OIO
5
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
32
PsiBlast_CBE
81.22
56%
-53
- C5 -
4G7Z
2
RPOB_THET8
M:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
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D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
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Y
P
L
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R
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Y
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N
Q
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V
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F
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A
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N
V
L
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M
P
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Y
N
F
E
D
A
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V
I
S
E
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L
L
K
R
D
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Y
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S
I
H
I
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Y
E
I
E
A
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D
T
K
L
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P
E
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I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
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F
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G
E
S
E
P
T
P
E
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R
L
L
R
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F
G
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A
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K
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P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
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V
V
R
V
Y
V
A
Q
K
R
K
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V
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D
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N
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L
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G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
65
PsiBlast_CBE
81.09
47%
-55
- C5 -
4YLN
1
RPOB_ECOLI
I:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
LEKDDVKLIEVPVEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
MELSL
D
L
L
A
K
LSQSGH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S------------
E
T
L
R
VD
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
80.96
47%
-54
- C5 -
4YLO
1
RPOB_ECOLI
I:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
LEKDDVKLIEVPVEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
MELSL
D
L
L
A
K
LSQSGH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S------------
E
T
L
R
VD
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
80.96
47%
-55
- C5 -
4YLP
1
RPOB_ECOLI
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
LEKDDVKLIEVPVEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
MELSL
D
L
L
A
K
LSQSGH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S------------
E
T
L
R
VD
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
80.55
47%
-53
- C5 -
4YLP
1
RPOB_ECOLI
I:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
LEKDDVKLIEVPVEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
MELSL
D
L
L
A
K
LSQSGH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S------------
E
T
L
R
VD
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.14
56%
-56
- C5 -
3AOH
2
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
63
PsiBlast_CBE
79.98
47%
-59
- C5 -
4YLO
1
RPOB_ECOLI
C:
[8-938]
------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
REAPEGT
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
SDK
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
-
I
L
D
L
F
----
F
E
-
K
V
I
F
E
I
R
D
-
N
K
L
Q
M
E
L
----
V
P
E
R
L
R
-
G
E
T
A
-
S
-----------------
F
D
I
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
---
A
R
H
I
R
Q
LEKDDVKLIEVPVEYIAGK
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
MELSL
D
L
L
A
K
LSQSGH
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S------------
E
T
L
R
VD
P
T
N
D
R
L
--
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
PPT
R
------
E
A
A
E
S
L
F
------------
E
N
L
F
F
S
E
D
R
Y
D
--------
L
S
A
VGRMKFNRSLLREEIEGSGILSK
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
--
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
----
V
N
E
D
E
M
YPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
-
D
V
Q
V
F
T
R
D
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.80
56%
-52
- C5 -
2O5I
3
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
22
PsiBlast_CBE
79.75
56%
-55
- C5 -
4WQS
2
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
41
PsiBlast_CBE
79.65
56%
-51
- C5 -
2O5I
3
RPOB_THET8
M:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
39
PsiBlast_CBE
79.59
56%
-50
- C5 -
2PPB
6
RPOB_THET8
M:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
40
PsiBlast_CBE
79.53
56%
-52
- C5 -
2O5J
5
RPOB_THET8
M:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
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F
M
D
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P
K
Q
V
F
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N
T
N
L
I
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F
L
E
H
D
D
A
N
R
A
L
M
G
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N
M
Q
T
Q
A
V
P
L
I
R
A
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A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
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N
Q
G
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A
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V
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L
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F
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A
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N
V
L
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M
P
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Y
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F
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A
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L
L
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I
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Y
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A
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L
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P
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T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
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F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
12
PsiBlast_PDB
79.33
56%
-51
- C5 -
2PPB
4
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
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D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
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F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
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P
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E
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F
M
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Q
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F
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N
T
N
L
I
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F
L
E
H
D
D
A
N
R
A
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M
G
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N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
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A
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D
Q
R
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V
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G
Q
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V
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G
D
L
L
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A
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N
G
F
L
A
L
G
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N
V
L
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A
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M
P
F
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G
Y
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F
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D
A
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I
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L
L
K
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Y
T
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I
H
I
E
R
Y
E
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E
A
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D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
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D
L
D
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E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
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F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
16
PsiBlast_PDB
79.29
56%
-54
- C5 -
3AOI
2
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
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G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
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A
K
L
V
N
S
R
P
L
E
A
A
I
R
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F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
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R
A
G
F
D
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R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
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G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
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R
V
V
A
R
R
K
G
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S
P
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F
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D
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K
Q
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N
T
N
L
I
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F
L
E
H
D
D
A
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A
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N
M
Q
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A
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P
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V
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G
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V
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S
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A
L
Y
A
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G
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A
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D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
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Y
P
L
R
R
F
Y
R
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N
Q
G
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A
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F
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A
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V
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F
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A
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L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
-----------------------
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
11
PsiBlast_PDB
79.28
56%
-53
- C5 -
2O5J
4
RPOB_THET8
C:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
21
PsiBlast_CBE
79.22
56%
-54
- C5 -
4WQS
2
RPOB_THET8
M:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-----------------------------
37
PsiBlast_CBE
79.21
56%
-55
- C5 -
3AOI
2
RPOB_THET8
M:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
---
Y
E
D
G
R
L
V
--------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
----------------------
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
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G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
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F
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V
L
V
K
E
L
Q
A
L
A
L
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V
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T
L
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D
N
P
V
D
I
-----------------------------
38
PsiBlast_CBE
79.12
56%
-55
- C5 -
3AOI
2
RPOB_THET8
H:
[303-1111]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
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Y
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A
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--
P
GH
E
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R
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--
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---
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--------------------------
K
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----------------------------------------------------------------------------------------------------
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------------------------------------------------------
Q
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-----------------------------
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FEVYFGKRKGEGFGVDKREVEVLRRAEKL
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--------------
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D
I
-----------------------------