@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0259: (2016-03-13 )
LLDVNNFEYMKIGLASPDKIRSWSHGEVKKPETINYRTLKPERDGLFCERIFGPMKDWECSCGKYKRVRYKGVVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLVMDMSPRALEEIIYFASYVVTEPGDTPLEKKQLLSEREYRVYREKYGKGFSAGMGAEAIKKILADIDLEKETNDLKEELKSAQGQRRTRAIRRLEVMEAFRNSGNNPSWMVLDVLPVIPPEIRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPNIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPNLKMYQCGLPKEMALELFKPFVMKELVGRGLAHNIKSAKRKIERMAPEIWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADFDGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLEREKAVGEGTIFKDINEAQLAYQNGYVHLHSRIAVFAGSIPNERFTDEQRNQLLITTVGKLIFNTILPKSFPYINEPTKFNLEIETPAKYFVDTTTDVRAHIAAQELIDPFKKKILGNIIAEVFKKFHITETSKMLDRMKDLGFKISTKAGMTVGIADILTLEEKHEILEKAHDTVEKITKSFRRGLITDDERYERVIAVWNAAKDEIQGKLILSLDRLNPIFMMQDSGARGNISNFTQLAGMRGLMADPSGRIVELPITSNFREGLTVLEYFISTHGARKGLTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLTIKAIREGTEIIEPLEERLEGRYSRKTIRHPETKEVIARENDLITEAIATQIVDAGIEEVTIRSAFTCNTKHGVCKKCYGKNLATGTEVEVGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQEIFEARNPKGQAIITEVGGEVVSIEEGRDRQQEITIQGTDDRRSYNIPYTARLRVEEGTIVERGEALTEGSVDPKALIRVRDVLSVQEYLLAEVQKVYRMQGVEIGDKHVEVMVRQMLRKIRVMDTGDTNILPGTLMDIHTFTEANREAILSGSQPATGRPVLLGITKASLETDSFLSAASFQETTRVLTDAAIKGKRDELLGLKENVILGKLVPAGTGIGRYRKLKSEVIKETAEVTDEITNI
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140----........150.......160..---------------------------------------------------------------------------------------------------------------------------------------------------------------------------.....170.......180.......190.......200........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......-310........320.......330.......340.......350.......360.......370.......380.......390---..---.....400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540---.---......550...---------....560....-...570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720--------------.---.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830...-------....840..-----.....850.......860......----.870.......880--.........890.......900.......910.......920.......930.......940.....-..--------950.......960.......970.......980.-......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180.---.....1190......1200
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LLDVNN
F
E
Y
M
K
IGLAS
P
D
K
IRSWSHGEVKKPETINYRTLKPERDG
L
F
C
E
R
I
FGPMKDWECSCGK
Y
K
R
V
R
Y
K
G
V
V
CDRCG
V
E
V
T
K
S
K
V
R
R
E
RMG
H
I
E
LAAPVS
H
I
W
Y
FKGIPSRM
G
L
V
MDM
S
P
R
A
L
E
E
I
I
Y
F
A
S
Y
VVTEPGD-----T
P
L
E
K
K
Q
L
L
S
E
R
E
Y
R
V
Y
R
E
KYGK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSAGM
G
A
E
A
I
K
K
I
L
A
DIDLEK
E
T
N
D
L
K
E
E
L
K
S
AQG
Q
-
R
R
T
R
A
I
R
R
L
E
V
M
E
A
F
R
NSGNNP
S
W
M
V
L
D
VLPVIPPEI
R
P
M
V
Q
LEGGRFATS
D
L
N
D
L
Y
R
R
V
INR
N
N
R
L
K
R
L
L
D
LGAP
N
I
I
VQ
N
E
K
R
M
L
Q
E
A
V
D
A
L
IDNGRRGRPVTGPG-N-R
P
L
K
S
L
S
H
M
L
KGKQG
R
F
R
Q
N
L
LGKRVDYSG
R
S
V
I
V
VGPN
L
K
M
Y
QCGL
P
K
E
M
A
L
E
L
F
K
P
F
V
M
K
E
L
V
G
R
G
L
A
H
N
I
K
S
A
K
R
K
I
E
R
---
M
A
---
P
E
I
W
D
V
L
E
E
V
I
R
EHPVLLNRAP
T
L
H
R
LGIQAFEPTLVEG
R
A
I
R
L
H
P
L
V
C
T
A
YNADFDGD
Q
M
A
V
H
VPLSAEAQA
E
A
R
I
L
M
L
A
A
Q
N
ILNPKDGKPVVTPSQ
D
M
V
L
G
N
Y
Y
L
T
L
E
REKAVGEG
T
I
F
K
DI
N
E
A
Q
L
A
YQN
G
Y
V
H
L
H
S
R
I
A
V
F
AG---S---IPNERF
T
D
E
Q
R
N
---------
Q
L
L
I
T
T
V
G
K
L
I
-
F
N
T
ILPKSFPYINEP
T
K
F
N
L
E
IETPA
K
Y
F
V
DTT
T
D
V
R
A
H
I
A
A
Q
E
L
I
D
P
F
K
K
K
I
L
G
N
I
I
A
E
V
F
K
K
FHIT
E
T
S
K
M
L
D
R
M
K
DL
G
F
K
I
STKA
G
M
T
V
G
I
A
D
I
L
T
L
E
E
K
H
E
I
L
E
K
A
H
D
T
V
E
K
I
T
K
S
F
R
RGLIT
D
D
E
R
Y
E
R
V
I
A
V
W
N
A
A
K
D
EIQ
G
K
L
I
L
S
LD---------------R---LN
P
I
F
M
M
QDSGARGN
I
S
N
F
T
Q
L
A
GMRGLMADPSG
R
I
V
E
L
PITS
N
F
R
E
G
L
T
V
L
E
Y
F
I
S
THGARKGLT
D
T
A
LKTAD
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
V
I
I
REDDCGTDRGL
T
I
K
A
I
RE
G
T
E
I
-------
I
E
P
L
E
E
R
L
E
-----
G
RYSRKTIRHP
E
T
K
E
V
I
AREN
D
L
I
----
T
E
A
I
A
T
Q
I
V
D
AG----I
E
E
V
T
I
R
S
A
F
TCNTKH
G
V
C
K
K
C
YGKNLATGT
E
V
E
VG
E
A
V
G
I
I
A
A
Q
SIGEPGT
Q
L
T
M
R
T
FHTGGVA
G
D
-
D
I
--------
T
Q
G
L
P
R
I
Q
E
I
F
E
ARNPKG
Q
A
I
I
TEVG
G
E
V
V
S
IEE-GRDR
Q
Q
E
I
T
I
QGTDD
R
R
SYNI
P
Y
T
A
R
L
R
VEEG
T
I
VERGEALTEGSV
D
P
K
A
L
I
R
V
R
D
V
L
S
V
Q
E
Y
L
L
A
E
V
Q
K
V
Y
R
MQGVEI
G
D
K
H
V
E
V
M
V
R
Q
M
L
R
K
I
R
V
MDTGDTNILPG
T
L
M
D
I
H
T
F
T
EA
N
R
E
A
ILSGSQPATGR
P
V
L
L
G
I
T
KASLET
D
S
F
L
S
A
A
S
F
Q
E
T
T
R
V
L
T
D
A
AIKGK
R
D
E
L
LGLKEN
V
I
L
G
K
LVPAGTG
I
G
R
Y
R
K
L
K
---
S
E
V
I
K
E
T
A
E
V
T
D
E
ITNI
68
Fugue
86.84
51%
-67
- C7 -
1IW7
6
RPOC_THET8
D:
[2-1505]
---
K
K
E
V
R
K
V
R
I
A
L
A
S
P
E
K
I
R
S
W
S
Y
G
E
V
E
K
P
E
T
I
N
Y
R
T
L
K
P
E
R
D
G
L
F
D
E
R
I
F
G
P
I
K
D
Y
E
C
A
C
G
K
Y
K
R
Q
R
F
E
G
K
V
C
E
R
C
G
V
E
V
T
K
S
I
V
R
R
Y
R
M
G
H
I
E
L
A
T
P
A
A
H
I
W
F
V
K
D
V
P
S
K
I
G
T
L
L
D
L
S
A
T
E
L
E
Q
V
L
Y
F
S
K
Y
I
V
L
D
P
K
G
AILNG
V
P
V
E
K
R
Q
L
L
T
D
E
E
Y
R
E
L
R
Y
G
K
Q
E
TYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGVALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEILAELPEPYLFGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRNVVRVVESY
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
-
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
---
Q
R
DIK
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
A
G
R
---
E
TSV
G
R
L
K
Y
V
F
A
N
P
D
E
---------
A
L
L
A
V
A
H
G
I
V
D
-
L
Q
D
V
V
--
T
V
R
Y
M
G
K
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
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K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
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G
I
D
D
A
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P
E
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K
K
Q
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A
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K
L
L
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Y
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M
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L
W
T
E
T
T
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K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
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L
R
G
L
M
Q
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V
P
V
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S
S
F
R
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G
L
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L
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Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
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D
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Y
L
T
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K
L
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V
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A
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C
G
T
T
N
Y
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V
P
L
F
Q
P
D
E
V
T
RSLRLRK
R
A
D
I
E
A
G
L
Y
-----
G
R
V
L
A
R
E
V
E
V
L
G
V
---
R
L
E
E
G
R
Y
L
SMDD
V
H
L
L
I
K
A
A
E
A
G
E
----
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
T
G
G
V
A
G
A
A
D
I
--------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
--
E
-
E
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
F
V
R
F
T
Q
VVD
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
V
E
A
41
PsiBlast_CBE
86.24
50%
-70
- C7 -
4G7O
6
RPOC_THET8
N:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
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M
L
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E
P
L
A
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P
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D
I
I
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L
Y
Y
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Q
V
R
K
E
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A
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L
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A
A
H
E
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G
E
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A
L
N
A
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V
-
A
G
RET
S
---
V
G
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L
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Y
V
F
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---------
E
A
L
L
A
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A
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V
D
L
Q
D
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--
T
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I
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I
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A
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V
A
W
E
L
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L
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D
L
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Y
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L
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M
E
K
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L
L
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A
L
K
Y
Y
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F
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T
T
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G
I
D
D
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K
Q
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L
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K
L
L
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M
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L
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Y
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I
L
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L
W
T
E
T
T
E
K
V
T
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A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
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Y
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L
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A
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C
G
T
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N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
ADIEA
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
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I
Q
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V
P
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R
S
P
L
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Y
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I
G
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P
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T
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L
T
M
-------
V
A
G
A
A
D
I
--------
T
Q
G
L
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R
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L
F
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A
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A
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A
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-
V
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L
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A
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A
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A
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W
L
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A
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A
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L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
36
PsiBlast_CBE
86.08
50%
-70
- C7 -
4OIN
7
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
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A
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M
K
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-
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L
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A
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---
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L
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---------
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A
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L
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I
V
D
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D
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A
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N
F
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---------------
E
NYP
F
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P
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-------
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L
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L
Y
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L
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V
R
L
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E
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R
Y
L
----
S
M
D
D
V
H
L
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K
A
A
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A
GE
I
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V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
---------------
I
--------
T
Q
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L
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R
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I
E
L
F
E
A
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R
P
K
A
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-
V
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V
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M
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Y
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L
L
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L
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W
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A
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N
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L
I
A
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T
P
V
A
W
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P
L
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K
S
A
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W
L
S
A
A
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F
Q
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T
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V
L
T
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A
A
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A
G
K
K
D
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L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
42
PsiBlast_CBE
85.74
50%
-70
- C7 -
4G7O
6
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
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E
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K
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P
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-
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R
A
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A
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P
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L
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L
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G
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V
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A
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M
L
E
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Q
RD
I
K
---
D
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---
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---------------
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NYP
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L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
--------------
I
--------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
E
E
-
T
E
E
K
L
S
-
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
34
PsiBlast_CBE
85.48
50%
-71
- C7 -
4OIP
9
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
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K
R
M
L
Q
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A
V
D
A
L
L
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N
G
R
R
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A
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V
T
N
P
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D
-
R
P
L
R
S
L
T
D
I
L
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G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
---
D
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W
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A
L
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I
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V
L
L
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A
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F
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S
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A
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I
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M
L
S
A
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P
L
A
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I
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R
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E
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K
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A
G
L
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A
L
A
A
H
E
R
G
E
V
A
L
N
A
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V
-
A
G
R
E
T
S
---
V
G
R
L
K
Y
V
F
A
N
P
D
---------
E
A
L
L
A
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
K
R
L
E
T
S
P
G
R
I
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F
A
R
I
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A
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A
V
E
D
E
K
V
A
W
E
L
I
Q
L
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P
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N
S
L
K
D
L
V
Y
Q
A
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L
R
L
G
M
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K
T
A
R
L
L
D
A
L
K
Y
Y
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T
F
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I
G
I
D
D
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K
Q
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K
L
L
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I
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Y
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M
G
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R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
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E
A
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C
G
T
T
N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
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G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
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P
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I
G
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A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
--------------
I
--------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
E
E
-
T
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K
L
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V
F
V
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S
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G
F
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K
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L
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A
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L
L
V
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D
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D
Y
V
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A
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A
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L
L
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A
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Y
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V
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E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
32
PsiBlast_CBE
85.33
50%
-70
- C7 -
4OIR
7
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
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M
I
L
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A
V
P
V
L
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P
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L
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M
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G
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D
L
N
D
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Y
R
R
L
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N
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R
L
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K
L
L
A
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G
A
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E
I
I
I
R
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K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
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V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
---
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
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L
V
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L
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A
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N
A
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D
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D
Q
M
A
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L
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S
F
A
Q
A
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A
R
I
Q
M
L
S
A
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N
L
L
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S
G
E
P
L
A
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P
S
R
D
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I
L
G
L
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Q
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R
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K
G
A
G
L
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A
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A
L
A
A
H
E
R
G
E
V
A
L
N
A
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I
K
V
-
A
G
R
E
T
S
---
V
G
R
L
K
Y
V
F
A
N
P
D
---------
E
A
L
L
A
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
K
R
L
E
T
S
P
G
R
I
L
F
A
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I
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A
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A
V
E
D
E
K
V
A
W
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L
I
Q
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N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
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M
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K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
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T
T
S
G
I
T
I
G
I
D
D
A
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I
P
E
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K
Q
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L
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K
L
L
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I
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Y
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M
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L
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Y
D
Q
I
L
Q
L
W
T
E
T
T
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K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
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A
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G
N
P
Q
Q
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L
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L
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D
V
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V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
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P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
-----------------------
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
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E
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T
E
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L
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V
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V
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F
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D
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A
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Q
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A
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Q
L
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A
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P
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A
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Y
L
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E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
44
PsiBlast_CBE
85.31
50%
-69
- C7 -
4G7H
6
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
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Q
V
D
G
G
R
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A
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D
L
N
D
L
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R
L
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R
N
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R
L
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K
L
L
A
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G
A
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E
I
I
I
R
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R
M
L
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E
A
V
D
A
L
L
D
N
G
R
R
G
A
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V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
Q
RD
I
K
---
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
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T
L
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I
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Q
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V
L
V
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S
I
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L
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---
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---------
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A
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N
F
E
---------------
E
NYP
F
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P
L
Y
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Q
Q
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Y
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L
F
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D
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V
-------
T
R
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L
R
L
R
K
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A
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I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
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A
A
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A
GE
I
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L
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--------------
I
--------
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A
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N
V
I
L
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R
L
I
P
A
G
T
G
----------------------------
39
PsiBlast_CBE
85.24
50%
-69
- C7 -
4G7Z
4
RPOC_THET8
N:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
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Q
L
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RET
S
---
V
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---------
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---------------
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V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
35
PsiBlast_CBE
85.18
50%
-70
- C7 -
4OIO
7
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
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A
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Q
Q
L
L
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L
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---
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V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
33
PsiBlast_CBE
85.12
50%
-70
- C7 -
4OIQ
7
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
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K
E
L
L
E
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M
K
H
P
S
R
A
-
R
R
A
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A
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K
R
L
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V
R
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F
L
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S
G
N
R
P
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W
M
I
L
E
A
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P
V
L
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D
L
R
P
M
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Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
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R
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R
L
K
K
L
L
A
Q
G
A
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E
I
I
I
R
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A
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A
L
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G
R
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V
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N
P
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D
-
R
P
L
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S
L
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Q
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N
L
L
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R
V
D
Y
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R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
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A
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R
M
L
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QRD
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K
---
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A
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---
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G
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L
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Y
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---------
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A
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L
A
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A
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I
V
D
L
Q
D
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--
T
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L
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P
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V
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L
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D
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Y
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L
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A
V
F
K
N
F
E
---------------
E
NYP
F
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P
L
Y
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Y
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L
F
Q
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-------
T
R
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L
R
L
R
K
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A
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A
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L
Y
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L
A
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V
L
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V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
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A
A
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A
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P
G
T
Q
L
T
M
-------------
I
--------
T
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L
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R
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I
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L
F
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A
R
R
P
K
A
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-
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V
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V
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M
M
K
Y
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R
L
L
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L
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K
W
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V
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A
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N
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R
L
I
A
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G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
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F
Q
N
T
T
H
V
L
T
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A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
43
PsiBlast_CBE
84.92
50%
-70
- C7 -
4G7H
3
RPOC_THET8
N:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
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K
E
L
L
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M
K
H
P
S
R
A
-
R
R
A
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A
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R
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V
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L
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G
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N
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P
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L
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K
Q
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F
R
Q
N
L
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R
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D
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V
I
V
V
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P
Q
L
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L
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Q
C
G
L
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L
L
K
K
M
E
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I
A
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V
K
A
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R
M
L
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QRD
I
K
---
D
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A
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I
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V
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A
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RET
S
---
V
G
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---------
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A
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A
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F
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---------------
E
NYP
F
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A
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G
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Y
I
S
V
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P
L
F
Q
P
D
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-------
T
R
S
L
R
L
R
K
R
ADIEA
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
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I
Q
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V
P
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S
P
L
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C
Q
T
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Y
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A
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E
P
G
T
Q
L
T
--------------
I
--------
T
Q
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L
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R
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I
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L
F
E
A
R
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K
A
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-
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M
K
Y
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D
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D
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R
L
L
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G
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L
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K
W
D
V
E
A
L
N
E
R
L
I
A
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K
T
P
V
A
W
K
P
L
L
M
G
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K
S
A
L
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W
L
S
A
A
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F
Q
N
T
T
H
V
L
T
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A
A
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A
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K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
40
PsiBlast_CBE
84.42
50%
-69
- C7 -
4G7Z
4
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
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A
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V
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A
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QRD
I
K
---
D
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---
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A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
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R
E
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I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
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K
L
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E
A
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C
G
T
T
N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
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P
L
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T
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C
Y
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I
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A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
--------------
I
--------
T
Q
G
L
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R
V
I
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L
F
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A
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R
P
K
A
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A
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I
S
E
I
D
G
-
V
V
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-
T
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K
L
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-
V
F
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G
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L
L
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Q
K
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Y
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G
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L
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D
K
H
I
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I
V
V
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M
M
K
Y
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L
L
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L
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W
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V
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A
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N
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R
L
I
A
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K
T
P
V
A
W
K
P
L
L
M
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K
S
A
L
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K
S
W
L
S
A
A
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F
Q
N
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H
V
L
T
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A
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A
G
K
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D
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L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
31
PsiBlast_CBE
84.30
50%
-70
- C7 -
4Q5S
5
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
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A
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Q
Q
L
L
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E
L
D
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QRD
I
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---
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A
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G
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V
-
A
G
RET
S
---
V
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R
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---------
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A
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--
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K
N
F
E
---------------
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NYP
F
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Q
P
D
E
V
-------
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L
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A
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L
Y
G
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R
E
V
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L
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V
R
L
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E
G
R
Y
L
----
S
M
D
D
V
H
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A
A
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A
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I
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I
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Q
S
I
G
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P
G
T
Q
L
T
M
-----------------------
Q
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L
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L
F
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A
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-
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M
M
K
Y
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L
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L
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W
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A
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R
L
I
A
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P
V
A
W
K
P
L
L
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K
S
A
L
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S
W
L
S
A
A
S
F
Q
N
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V
L
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A
G
K
K
D
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L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
23
PsiBlast_CBE
83.89
51%
-74
- C7 -
4YLP
1
RPOC_ECOLI
J:
[17-1031]
------
F
D
A
I
K
I
A
L
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M
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R
S
W
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F
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V
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G
M
-----
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Y
L
D
A
L
E
E
F
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
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M
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A
L
L
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---
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---
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--------------
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---------------------------
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L
Q
TETVINRDGQEEKQV
S
---
F
N
S
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M
A
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A
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----
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I
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G
T
Q
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R
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G
G
A
A
S
R
-
A
A
AESSIQVK
N
K
G
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V
K
S
V
V
N
S
S
G
K
L
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R
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E
L
K
L
I
D
E
F
G
R
T
K
E
------------
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Y
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L
A
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G
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--
T
V
A
N
W
D
P
H
T
M
P
V
I
T
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.77
51%
-77
- C7 -
4YLN
1
RPOC_ECOLI
D:
[17-1031]
------
F
D
A
I
K
I
A
L
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S
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---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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--------------
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TETVINRDGQEEKQV
S
---
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AESSIQVK
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V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.69
51%
-72
- C7 -
4YLO
1
RPOC_ECOLI
D:
[17-1031]
------
F
D
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--------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
83.54
50%
-66
- C7 -
2A6H
3
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
E
E
-
T
E
E
K
L
S
-
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
2
PsiBlast_PDB
83.36
51%
-80
- C7 -
4JKR
5
?
D:
[17-1040]
------
F
D
A
I
K
I
A
L
A
S
P
D
M
I
R
S
W
S
F
G
E
V
K
K
P
E
T
I
N
Y
R
T
F
K
P
E
R
D
G
L
F
C
A
R
I
F
G
P
V
K
D
Y
E
C
L
C
G
K
Y
K
R
L
K
H
R
G
V
I
C
E
K
C
G
V
E
V
T
Q
T
K
V
R
R
E
R
M
G
H
I
E
L
A
S
P
T
A
H
I
W
F
L
K
S
L
P
S
R
I
G
L
L
L
D
M
P
L
R
D
I
E
R
V
L
Y
F
E
S
Y
V
V
I
E
G
G
M
-----
T
N
L
E
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
D
A
K
M
G
A
E
A
I
Q
A
L
L
K
S
M
D
L
E
Q
E
C
E
Q
L
R
E
E
L
N
E
T
N
S
E
T
K
R
K
K
L
T
K
R
I
K
L
L
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A
F
V
Q
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G
N
K
P
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W
M
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T
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L
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L
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D
L
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P
L
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G
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N
D
L
Y
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V
I
N
R
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N
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L
K
R
L
L
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L
A
A
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V
R
N
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M
L
Q
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A
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D
A
L
L
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G
R
R
G
R
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T
G
S
N
-
K
-
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P
L
K
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L
A
D
M
I
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K
Q
G
R
F
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L
L
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D
Y
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V
I
T
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L
R
L
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L
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L
E
L
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G
K
L
E
L
R
G
L
A
T
T
I
K
A
A
K
K
M
V
E
R
---
E
E
---
A
V
V
W
D
I
L
D
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R
E
H
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V
L
L
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R
A
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L
H
R
L
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K
A
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Q
L
H
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A
A
Y
N
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F
D
G
D
Q
M
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V
H
V
P
L
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L
E
A
Q
L
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A
L
M
M
S
T
N
N
I
L
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A
N
G
E
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V
P
S
Q
D
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V
L
G
L
Y
Y
M
T
R
D
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K
G
E
G
M
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L
T
G
P
K
E
A
E
R
L
Y
R
S
G
L
A
S
L
H
A
R
V
K
V
--------------
R
I
T
E
Y
E
K
D
ANGELVAKT
S
L
K
D
T
T
V
G
R
A
I
-
L
W
M
I
V
P
K
G
L
P
Y
---------------------------
S
I
V
N
Q
A
L
----
G
K
K
A
I
S
K
M
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C
Y
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L
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I
P
E
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S
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A
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V
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Q
E
Q
F
Q
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L
V
T
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R
Y
N
K
V
I
D
I
W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
TETVINRDGQEEKQV
S
---
F
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
G
M
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L
M
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S
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I
T
A
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F
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L
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Y
F
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A
R
K
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T
A
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S
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R
L
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D
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D
D
C
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T
H
E
G
I
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P
V
I
E
G
G
D
V
-------
K
E
P
L
R
D
R
V
L
-----
G
R
V
T
A
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D
V
L
K
P
G
T
A
D
I
L
V
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R
N
T
L
L
----
H
E
Q
W
C
D
L
L
E
E
N
S
----
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
A
Q
S
I
G
E
P
G
T
Q
L
----------------ESSIQVK-
N
K
G
S
I
K
L
S
N
V
K
S
V
V
N
S
S
G
K
L
V
I
T
S
R
N
T
E
L
K
L
I
D
E
F
G
R
T
K
E
------------
S
Y
K
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P
Y
G
A
V
L
A
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G
D
G
E
Q
V
A
G
G
E
--
T
V
A
N
W
D
P
H
T
M
P
V
I
T
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
83.31
50%
-66
- C7 -
2PPB
9
RPOC_THET8
N:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
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E
L
D
L
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E
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M
K
H
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A
-
R
R
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A
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K
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V
R
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R
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I
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N
V
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A
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R
M
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QRD
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K
---
D
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W
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A
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-
A
G
RET
S
---
V
G
R
L
K
Y
V
F
A
N
P
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---------
E
A
L
L
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A
H
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L
Q
D
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--
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K
N
F
E
---------------
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F
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ADIEA
G
L
Y
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R
E
V
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L
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M
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--------
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L
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W
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A
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L
I
A
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T
P
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L
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L
K
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N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
45
PsiBlast_CBE
83.24
50%
-66
- C7 -
3WOD
1
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
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A
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E
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K
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A
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RET
S
---
V
G
R
L
K
Y
V
F
A
N
P
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---------
E
A
L
L
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I
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D
L
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D
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--
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R
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A
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A
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F
K
N
F
E
---------------
E
NYP
F
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-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
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K
R
A
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I
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A
G
L
Y
G
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L
A
R
E
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G
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L
E
E
G
R
Y
L
----
S
M
D
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I
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A
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GE
I
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T
Q
L
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M
------------------------
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L
F
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-
V
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V
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L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
27
PsiBlast_CBE
82.99
51%
-77
- C7 -
4YLN
1
RPOC_ECOLI
J:
[17-1031]
------
F
D
A
I
K
I
A
L
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M
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R
S
W
S
F
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-----
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A
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F
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
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---
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---
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A
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L
H
A
R
V
K
V
--------------
R
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ANGELVAKT
S
L
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R
A
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-
L
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P
K
G
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Y
---------------------------
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----
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N
L
Q
TETVINRDGQEEKQV
S
---
F
N
S
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Y
M
M
A
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A
R
G
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A
A
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-------
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----
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----
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A
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I
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G
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Q
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R
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F
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G
G
A
A
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R
-
A
A
AESSIQVK
N
K
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N
V
K
S
V
V
N
S
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K
L
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L
K
L
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D
E
F
G
R
T
K
E
------------
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Y
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Y
G
A
V
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A
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G
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G
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A
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--
T
V
A
N
W
D
P
H
T
M
P
V
I
T
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.96
51%
-74
- C7 -
4YLP
1
RPOC_ECOLI
D:
[17-1031]
------
F
D
A
I
K
I
A
L
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V
V
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-----
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Y
L
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A
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F
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
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A
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A
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--------------
R
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ANGELVAKT
S
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A
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P
K
G
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P
Y
---------------------------
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V
S
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A
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N
L
Q
TETVINRDGQEEKQV
S
---
F
N
S
I
Y
M
M
A
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A
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-------
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----
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----
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Q
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T
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R
T
F
H
I
G
G
A
A
S
R
-
A
A
AESSIQVK
N
K
G
S
I
K
L
S
N
V
K
S
V
V
N
S
S
G
K
L
V
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T
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L
K
L
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D
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F
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R
T
K
E
------------
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Y
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A
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--
T
V
A
N
W
D
P
H
T
M
P
V
I
T
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
82.65
50%
-68
- C7 -
3AOI
5
RPOC_THET8
I:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
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Q
L
L
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E
L
D
L
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E
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K
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R
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------------
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RET
S
---
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---------
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---------------
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F
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-------
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ADIEA
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----
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M
R
---------------------
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V
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R
L
I
P
A
G
T
G
----------------------------
25
PsiBlast_CBE
82.59
51%
-73
- C7 -
4YLO
1
RPOC_ECOLI
J:
[17-1031]
------
F
D
A
I
K
I
A
L
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D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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--------------
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---------------------------
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TETVINRDGQEEKQV
S
---
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A
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A
A
AESSIQVK
N
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W
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T
M
P
V
I
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E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
82.43
50%
-67
- C7 -
3AOI
3
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
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V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
-------------
D
I
--------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
E
E
-
T
E
E
K
L
S
-
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
19
PsiBlast_PDB
82.39
50%
-66
- C7 -
2O5I
6
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
---
D
E
V
W
D
A
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K
V
V
L
L
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R
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E
A
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N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
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T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
-
A
G
RET
S
---
V
G
R
L
K
Y
V
F
A
N
P
D
---------
E
A
L
L
A
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
K
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
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T
F
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V
P
V
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S
F
R
E
G
L
T
V
L
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Y
F
I
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S
H
G
A
R
K
G
G
A
D
T
A
L
R
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A
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S
G
Y
L
T
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K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
ADIEA
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
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R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
--------------------------
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
E
E
-
T
E
E
K
L
S
-
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
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A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
55
PsiBlast_CBE
82.15
50%
-67
- C7 -
2PPB
8
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
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A
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E
I
I
I
R
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K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
---
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
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T
L
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C
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D
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M
A
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L
S
S
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A
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A
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I
Q
M
L
S
A
H
N
L
L
S
P
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G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
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Q
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R
K
E
K
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A
G
L
E
F
A
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A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
-
A
G
RET
S
---
V
G
R
L
K
Y
V
F
A
N
P
D
---------
E
A
L
L
A
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
K
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
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D
E
K
V
A
W
E
L
I
Q
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P
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S
L
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D
L
V
Y
Q
A
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L
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L
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M
E
K
T
A
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L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
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K
K
Q
Y
L
E
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D
R
K
L
L
Q
I
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Q
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Y
E
M
G
F
L
T
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E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
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Y
L
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I
V
V
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A
D
C
G
T
T
N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
ADIEA
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
T
-------
D
I
--------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
E
E
-
T
E
E
K
L
S
-
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
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A
G
Q
P
L
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I
D
P
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Q
L
L
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A
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P
E
A
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E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
50
PsiBlast_CBE
81.75
50%
-67
- C7 -
3AOI
2
RPOC_THET8
N:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
-----------
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
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E
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R
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E
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A
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L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
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R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
---
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
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R
A
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T
L
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R
L
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I
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L
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D
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Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
-
A
G
RET
S
---
V
G
R
L
K
Y
V
F
A
N
P
D
---------
E
A
L
L
A
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
K
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
ADIEA
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
-------------
D
I
--------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
E
E
-
T
E
E
K
L
S
-
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
57
PsiBlast_CBE
81.58
50%
-68
- C7 -
2O5I
5
RPOC_THET8
N:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
---
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
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Q
S
I
Q
L
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L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
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L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
-
A
G
RET
S
---
V
G
R
L
K
Y
V
F
A
N
P
D
---------
E
A
L
L
A
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
K
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
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T
F
E
V
P
V
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S
S
F
R
E
G
L
T
V
L
E
Y
F
I
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S
H
G
A
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K
G
G
A
D
T
A
L
R
T
A
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S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
ADIEA
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
--------------------------
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
-
V
V
R
I
E
E
-
T
E
E
K
L
S
-
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
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A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
20
PsiBlast_PDB
79.50
50%
-65
- C7 -
2O5J
7
RPOC_THET8
D:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
-
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
---
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
-
A
G
RET
S
---
V
G
R
L
K
Y
V
F
A
N
P
D
---------
E
A
L
L
A
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
K
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
---------------
E
NYP
F
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
-
P
L
F
Q
P
D
E
V
-------
T
R
S
L
R
L
R
K
R
ADIEA
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
----
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
T
G
G
V
A
G
A
A
D
I
--------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
------------------------------------------------------------
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
----------------------------
56
PsiBlast_CBE
79.49
50%
-64
- C7 -
2O5J
7
RPOC_THET8
N:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
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L
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QRD
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---
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I
K
V
-
A
G
RET
S
---
V
G
R
L
K
Y
V
F
A
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P
D
---------
E
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---------------
E
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Y
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L
F
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-------
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ADIEA
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----
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I
--------
T
Q
G
L
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R
R
P
K
A
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------------------------------------------------------------
A
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D
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V
I
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L
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P
A
G
T
G
----------------------------
30
PsiBlast_CBE
78.18
50%
-61
- C7 -
4WQS
3
RPOC_THET8
N:
[452-1477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
R
M
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----------------------------