@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0263: (2016-03-13 )
MKKRWNSVFKLVLMVTAILGLSLYVTTSQGVEVRAESITQPTAINVIFPDPALANAIKIAAGKSNVTDTVTQADLDGITTLSAFGTGVTTIEGVQYLNNLIGLELKDNQITDLTPLKNLTKITELELSGNPLKNVSAIAGLQSIKTLDLTSTQITDVTPLAGLSNLQVLYLDLNQITNISPLAGLTNLQYLSIGNAQVSDLTPLANLSKLTTLKADDNKISDISPLASLPNLIEVHLKNNQISDVSPLANTSNLFIVTLTNQTITNQPVFYQNNLVVPNVVKGPSGAPIAPATISDNGTYASPNLTWNLTSFINNVSYTFNQSVTFKNTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTVGANELIKEPTAPTKEGYTFTGWYDAKTGGTKWDFATDKMPAEDITLYAQFTINSYTATFDIDGKLTTQKVTYQSLLEEPVAPTKDGYTFTGWYDAKTGGTKWDFATGKMPAGNITLYAQFTKNDNPNPDDPTTNTPTGNGDGTSNPSNSGGNTTLPTAGDENTMLPIFIGVFLLGTATLILRKTIKVK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.----------------...----------...140.......150.......--160.......170.......--180.......190.......200.--......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340..---.....350.......360--.........370.......380.......390..--.....400.......410..------------------.....420.......430.-----......440.......450----.........460.......470.......480.......490.......500.......510.......520.......530.......540......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
R
W
N
S
V
F
K
L
V
L
M
V
T
A
I
LG
L
S
L
Y
V
TTSQG
V
E
V
R
AESITQP
T
A
I
N
V
IFPDP
A
L
A
N
A
I
K
IAAGKSNVTD
T
V
T
QADLDG
I
T
T
L
S
AFGTGV
T
T
I
E
G
V
Q
Y
L
N
N
LIG
L
E
LKDNQITDLTPLK
N
L
T
K
I
T
E
L
E
LSGNPL
K
----------------
N
V
S
----------
A
I
AGLQ
S
I
K
T
LDLTSTQITDVTP--LAGLSN
L
Q
V
L
Y
L
D
L
N
QITNI--SPLAGLT
N
L
Q
Y
L
SIGNAQVSDLTP--LAN
L
S
K
L
T
T
LKADDNKISDI
S
P
L
A
SLPN
L
I
E
V
H
LKNNQISDVSPLANTS
N
L
F
I
V
T
LTNQTITNQ
P
V
F
Y
QNNLVVPNVVKGPSGAPIA
P
A
TISDNGTYASP
N
L
T
W
N
L
T
S
F
INN
V
S
Y
T
FNQ
S
V
T
FKNTTVPFSGTVTQ
P
L
T
E
A
---
Y
T
A
V
F
DVDGK
Q
T
S
V
T
V----G
A
N
E
L
IKEPTAPTKE
G
Y
T
F
T
G
W
Y
DAKTGGTKWDF--ATDKMPAE
D
I
T
L
Y
A
Q
F
T
IN
S
------------------
Y
T
A
T
F
D
IDGKLT
T
Q
K
V
T
Y
Q
-----
S
L
L
EEPVAPTKDG
Y
T
F
T
------
G
W
Y
DAKTGGTKWDFATGKMPAG
N
I
T
L
Y
A
Q
FTKNDNPNPDDPTTNTPTGNGDGTSNPSNSGGNTTLPTAGDENT
M
L
P
I
F
I
G
V
F
L
L
G
T
A
T
L
I
L
R
K
TIKVK
70
HHSearch
87.06
99%
-129
- C3 -
1H6U
-
?
A:
[38-342]
-------------------------------------
I
T
Q
P
T
A
I
N
V
I
F
P
D
P
A
L
A
N
A
I
K
I
A
A
G
K
S
N
V
T
D
T
V
T
Q
A
D
L
D
G
I
T
T
L
S
A
F
G
T
G
V
T
T
I
E
G
V
Q
Y
L
N
N
L
I
G
L
E
L
K
D
N
Q
I
T
D
L
A
P
L
K
N
L
T
K
I
T
E
L
E
L
S
G
N
P
L
K
----------------
N
V
S
----------
A
I
A
G
L
Q
S
I
K
T
L
D
L
T
S
T
Q
I
T
D
V
T
P
--
L
A
G
L
S
N
L
Q
V
L
Y
L
D
L
N
Q
I
T
N
I
--
S
P
L
A
G
L
T
N
L
Q
Y
L
S
I
G
N
A
Q
V
S
D
L
T
P
--
L
A
N
L
S
K
L
T
T
L
K
A
D
D
N
K
I
S
D
I
S
P
L
A
S
L
P
N
L
I
E
V
H
L
K
N
N
Q
I
S
D
V
S
P
L
A
N
T
S
N
L
F
I
V
T
L
T
N
Q
T
I
T
N
Q
P
V
F
Y
N
N
N
L
V
V
P
N
V
V
K
G
P
S
G
A
P
I
A
P
A
T
I
S
D
N
G
T
Y
A
S
P
N
L
T
W
N
L
T
S
F
I
N
N
V
S
Y
T
F
N
Q
S
V
T
F
K
N
T
T
V
P
F
S
G
T
V
T
Q
P
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.87
99%
-128
- C3 -
1H6U
-
?
A:
[37-343]
------------------------------------
S
I
T
Q
P
T
A
I
N
V
I
F
P
D
P
A
L
A
N
A
I
K
I
A
A
G
K
S
N
V
T
D
T
V
T
Q
A
D
L
D
G
I
T
T
L
S
A
F
G
T
G
V
T
T
I
E
G
V
Q
Y
L
N
N
L
I
G
L
E
L
K
D
N
Q
I
T
D
L
A
P
L
K
N
L
T
K
I
T
E
L
E
L
S
G
N
P
L
K
----------------
N
V
S
----------
A
I
A
G
L
Q
S
I
K
T
L
D
L
T
S
T
Q
I
T
D
V
T
P
--
L
A
G
L
S
N
L
Q
V
L
Y
L
D
L
N
Q
I
T
N
I
--
S
P
L
A
G
L
T
N
L
Q
Y
L
S
I
G
N
A
Q
V
S
D
L
T
P
--
L
A
N
L
S
K
L
T
T
L
K
A
D
D
N
K
I
S
D
I
S
P
L
A
S
L
P
N
L
I
E
V
H
L
K
N
N
Q
I
S
D
V
S
P
L
A
N
T
S
N
L
F
I
V
T
L
T
N
Q
T
I
T
N
Q
P
V
F
Y
N
N
N
L
V
V
P
N
V
V
K
G
P
S
G
A
P
I
A
P
A
T
I
S
D
N
G
T
Y
A
S
P
N
L
T
W
N
L
T
S
F
I
N
N
V
S
Y
T
F
N
Q
S
V
T
F
K
N
T
T
V
P
F
S
G
T
V
T
Q
P
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.53
93%
-134
- C3 -
4FHO
1
?
A:
[6-231]
----------------------------------
A
E
S
I
A
Q
P
T
P
I
N
V
I
F
P
D
P
A
L
A
N
A
V
K
T
A
T
G
K
S
N
V
T
D
A
V
T
Q
A
D
L
D
G
I
A
T
L
S
A
F
N
T
G
V
T
T
I
E
G
I
Q
Y
L
N
N
L
I
G
L
E
L
K
D
N
Q
I
T
D
L
T
P
L
K
N
L
T
K
I
T
E
L
E
L
S
G
N
P
L
K
----------------
N
V
S
----------
A
I
A
G
L
Q
S
I
K
T
L
D
L
T
S
T
Q
I
T
D
V
T
P
--
L
A
G
L
S
N
L
Q
V
L
Y
L
D
L
N
Q
I
T
N
I
--
S
P
L
A
G
L
T
N
L
Q
Y
L
S
I
G
N
N
Q
V
N
D
L
T
P
--
L
A
N
L
S
K
L
T
T
L
R
A
D
D
N
K
I
S
D
I
S
P
L
A
S
L
P
N
L
I
E
V
H
L
K
D
N
Q
I
S
D
V
S
P
L
A
N
L
S
N
L
F
I
V
T
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
70.24
42%
-116
- C3 -
4AW4
6
INLB_LISMO
C:
[4-310]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
L
T
S
L
N
L
S
N
N
Q
I
T
D
I
S
P
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
70.05
42%
-117
- C3 -
4AW4
9
INLB_LISMO
B:
[4-310]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
L
T
S
L
N
L
S
N
N
Q
I
T
D
I
S
P
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.34
42%
-119
- C3 -
4AW4
14
INLB_LISMO
A:
[4-310]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
L
T
S
L
N
L
S
N
N
Q
I
T
D
I
S
P
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
------
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.79
39%
-117
- C3 -
2WQU
6
INLB_LISMO
F:
[5-288]
------------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
67.34
38%
-118
- C3 -
2WQW
7
INLB_LISMO
B:
[1-286]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
C
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
C
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
A
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.27
39%
-120
- C3 -
2WQU
7
INLB_LISMO
A:
[4-288]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.11
38%
-118
- C3 -
2WQW
5
INLB_LISMO
A:
[1-286]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
C
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
C
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
A
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
66.91
31%
-72
- C3 -
1M9S
8
INLB_LISMO
A:
[3-596]
-----------------------------------
E
T
I
T
V
S
T
P
I
K
Q
I
F
P
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
T
N
L
K
N
L
G
W
L
F
L
D
E
N
K
I
K
----------------
D
L
S
----------
S
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
N
G
--
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
--
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
------------------------
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
E
T
T
EKT
V
N
L
T
R
Y
V
K
Y
I
R
G
N
A
G
I
Y
KLP
R
E
D
N
S
L
K
Q
G
T
L
A
S
H
R
C
K
A
L
T
V
D
R
E
A
R
N
G
G
K
L
W
Y
R
L
K
N
I
G
W
T
K
A
E
N
L
S
L
D
R
Y
D
K
M
E
Y
D
K
G
V
T
A
Y
A
R
VRNASG
N
S
V
W
T
K
P
Y
N
T
A
G
A
K
H
V
N
K
L
S
V
Y
QG
K
N
M
R
I
L
R
E
A
K
T
P
I
T
T
W
Y
Q
F
S
I
GG
K
V
I
G
W
V
D
T
R
A
L
N
T
F
Y
K
Q
S
M
E
--
K
P
T
R
L
T
R
Y
V
S
A
N
K
A
G
E
S
Y
Y
K
V
P
V
A
D
N
P
V
K
R
G
T
L
A
K
Y
K
N
Q
K
L
I
V
D
C
Q
A
T
I
E
G
-
Q
L
W
Y
R
I
R
T
S
S
T
F
I
G
---
W
T
K
A
A
N
L
R
A
Q
26
PsiBlast_CBE
66.91
39%
-114
- C3 -
2WQU
5
INLB_LISMO
E:
[5-288]
------------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.90
39%
-113
- C3 -
2WQV
4
INLB_LISMO
A:
[5-288]
------------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
----
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
66.68
39%
-115
- C3 -
2WQV
5
INLB_LISMO
B:
[5-288]
------------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
65.68
39%
-115
- C3 -
1H6T
-
INLB_LISMO
A:
[35-321]
----------------------------------
S
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
65.24
42%
-112
- C3 -
1H6T
-
INLB_LISMO
A:
[37-320]
------------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
----------------
D
L
S
----------
S
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
N
G
--
L
V
H
------------------------
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
64.90
39%
-110
- C3 -
2WQU
6
INLB_LISMO
B:
[4-288]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
-----
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.58
39%
-112
- C3 -
2UZX
-
INLB_LISMO
A:
[36-320]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
64.47
42%
-112
- C3 -
1H6T
-
INLB_LISMO
A:
[31-321]
------------------------------
G
P
L
G
S
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
----------------
D
L
S
----------
S
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
N
G
--
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
--
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
------------------------
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.19
39%
-110
- C3 -
2UZY
-
INLB_LISMO
A:
[36-320]
-----------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
----------------------
V
T
K
L
F
L
N
G
N
K
L
T
----------------
D
I
K
----------
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
V
K
D
L
S
S
--
L
K
D
L
K
K
L
K
S
L
S
L
E
H
N
G
I
S
D
I
--
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
I
T
D
I
T
V
--
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
R
A
L
A
G
L
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
55.53
35%
-115
- C3 -
4R5C
2
?
A:
[1-261]
------------------------------------
T
I
T
V
S
T
P
I
K
Q
I
F
P
D
D
A
F
A
E
T
I
K
A
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
R
Y
L
A
L
G
G
N
K
L
H
D
I
S
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
Q
L
E
TLPQGVFEKLTNLTTL
N
L
S
NNQLTSLPQG
V
F
E
R
L
A
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
GV
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
PQ
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
GV
F
E
R
L
T
S
L
H
T
L
D
L
S
N
N
G
I
T
D
I
S
A
L
K
N
L
D
N
L
H
T
L
D
L
S
N
N
G
I
T
D
I
S
A
L
K
N
L
D
N
L
H
T
L
D
L
S
N
N
G
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------