@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0272: (2016-03-14 )
LYKLIAIDIDGTLLTDDHKVTDEVKEAIRQAKLKGVKVVLCTGRPLVGVENYLTELELREEGDYVISFNGAFVQDTFTKEVISHLTLGIEDLKDIYEVSLNSNLHMHFFDDKALYTPNREIGKYTIVEAYLTGSQLIYKEIENVPEDFIMSKAMFIEEAPELEVGIAKIPESFREKYHLVRSTPFYLEILNRDASKGNAVKELSEKLGIKQSEVICIGDQENDVTMLEFAGLGIAMGNAPERIKQLADYTTASNNDSGVAKAIQKFVLDK
Atome Classification :
(20 SA)
.........10....-....20........30........40........50....-....60........70........80-.........90........100----..-......110--.....--..-------120...-...---------------------.130.--..---..---------..-.140------....---.-.---..--.150....-....-.160.......170-.......180.......190.......200.......210.......220.......230.......240......--.--250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
L
Y
K
L
I
A
I
DIDG
T
L
LT-DDH
K
V
T
D
E
V
K
E
A
I
R
Q
AKLKG
V
K
V
V
L
CTGRPLV
G
V
E
N
Y
L
T
E
-
L
ELREEG
D
Y
V
I
S
FNG
A
F
V
Q
D
T
F
T
K
E
--
V
I
S
H
L
T
L
G
I
E
D
L
K
D
I
Y
E
V
SLN-----S
N
-
L
H
M
H
F
FDDK--ALYTP--NR-------EIG
K
Y
T
-
I
V
E
---------------------
A
Y-LT--G
S
---
Q
L
---------
I
Y
-
K
E
--------
I
E
NV---
P
-
E
---
D
F
--
I
M
--
S
K
A
M
-
F
IEE-APELE
V
G
I
A
KI
P
E
S
-
F
R
E
K
Y
H
L
VRST
P
F
Y
L
E
I
L
NRDASKG
N
A
V
K
E
L
S
E
KLGIKQS
E
V
I
C
IGDQEN
D
V
T
M
L
E
FAGL
G
I
AMGN
A
P
E
R
I
K
Q
L
A
D--Y--TTASNND
S
G
V
A
K
A
I
Q
K
F
VLDK--
64
HHSearch
94.80
43%
-105
- C4 -
1RKQ
2
YIDA_ECOLI
A:
[4-272]
A
I
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
-
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
Q
K
A
A
D
G
S
--
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
-----
V
G
-
S
H
F
H
A
L
D
R
T
--
T
L
Y
T
A
--
N
R
-------
D
I
S
Y
Y
T
-
V
H
E
---------------------
S
F
-
V
A
--
T
I
---
P
L
---------
V
F
-
C
E
--------
A
E
K
M
---
D
-
P
---
N
T
--
Q
F
--
L
K
V
M
-
M
I
D
E
-
P
A
I
L
D
Q
A
I
A
R
I
P
Q
E
-
V
K
E
K
Y
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
--
F
--
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
N
---
21
PsiBlast_CBE
94.31
43%
-104
- C4 -
1RKQ
2
YIDA_ECOLI
B:
[6-272]
--
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
-
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
Q
K
A
A
D
G
S
--
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
-----
V
G
-
S
H
F
H
A
L
D
R
T
--
T
L
Y
T
A
--
N
R
-------
D
I
S
Y
Y
T
-
V
H
E
---------------------
S
F
-
V
A
--
T
I
---
P
L
---------
V
F
-
C
E
--------
A
E
K
M
---
D
-
P
---
N
T
--
Q
F
--
L
K
V
M
-
M
I
D
E
-
P
A
I
L
D
Q
A
I
A
R
I
P
Q
E
-
V
K
E
K
Y
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
--
F
--
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
N
---
1
PsiBlast_PDB
93.79
43%
-103
- C4 -
1RKQ
2
YIDA_ECOLI
A:
[6-272]
--
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
-
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
Q
K
A
A
D
G
S
--
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
-----
V
G
-
S
H
F
H
A
L
D
R
T
--
T
L
Y
T
A
--
N
R
-------
D
I
S
Y
Y
T
-
V
H
E
---------------------
S
F
-
V
A
--
T
I
---
P
L
---------
V
F
-
C
E
--------
A
E
K
M
---
D
-
P
---
N
T
--
Q
F
--
L
K
V
M
-
M
I
D
E
-
P
A
I
L
D
Q
A
I
A
R
I
P
Q
E
-
V
K
E
K
Y
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
--
F
--
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
N
---
2
PsiBlast_PDB
83.81
31%
-104
- C4 -
4DW8
4
?
A:
[5-268]
-
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
E
-
L
R
M
N
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
I
N
W
E
S
K
E
--
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
-----
N
H
-
L
S
I
L
T
Y
D
G
A
--
E
I
V
T
E
--
N
--------
S
L
D
P
Y
V
-
Q
K
E
---------------------
A
F
-
L
----
N
---
K
M
---------
A
I
-
R
E
--------
T
N
D
F
---
L
-
T
---
D
I
--
T
L
PV
A
K
C
L
-
I
V
G
D
-
A
G
K
L
I
P
V
E
S
E
L
C
I
R
-
L
Q
G
K
I
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
--
Y
--
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
------
3
PsiBlast_PDB
82.72
30%
-99
- C4 -
3NIW
2
?
A:
[5-268]
-
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
E
-
L
R
M
N
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
I
N
W
E
S
K
E
--
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
-----
N
H
-
L
S
I
L
T
Y
D
G
A
--
E
I
V
T
E
--
N
--------
S
L
D
P
Y
V
-
Q
K
E
---------------------
A
F
-
L
N
--
K
M
---
A
I
------------
R
E
--------
T
N
D
F
---
L
-
T
---
D
I
--
T
L
PV
A
K
C
L
-
I
V
G
D
-
A
G
K
L
I
P
V
E
S
E
L
C
I
R
-
L
Q
G
K
I
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
--
Y
--
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
------
22
PsiBlast_CBE
82.59
31%
-105
- C4 -
1NF2
3
?
C:
[1-264]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
K
C
Y
-
V
V
F
A
S
G
R
M
L
V
S
T
L
N
--
V
E
-
K
K
Y
F
K
R
T
F
P
T
I
A
Y
N
G
A
I
V
---
Y
L
P
E
EG
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
-----
L
N
-
V
H
W
Q
A
Y
I
D
D
--
V
L
Y
S
E
KD
N
E
-------
E
I
-------
K
---------------------
S
Y
-
A
R
--
H
S
---
N
V
---------
D
Y
-
R
V
--------
E
P
N
L
---
S
-
E
LVS
K
M
--
G
T
--
T
K
L
L
-
L
I
D
T
-
P
E
R
L
D
E
L
K
E
I
L
S
E
R
-
F
K
D
V
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
D
---
23
PsiBlast_CBE
82.21
31%
-102
- C4 -
1NF2
3
?
B:
[1-264]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
K
C
Y
-
V
V
F
A
S
G
R
M
L
V
S
T
L
N
--
V
E
-
K
K
Y
F
K
R
T
F
P
T
I
A
Y
N
G
A
I
V
---
Y
L
P
E
EG
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
-----
L
N
-
V
H
W
Q
A
Y
I
D
D
--
V
L
Y
S
E
KD
N
E
-------
E
I
-------
K
---------------------
S
Y
-
A
R
--
H
S
---
N
V
---------
D
Y
-
R
V
--------
E
P
N
L
---
S
-
E
LVS
K
M
--
G
T
--
T
K
L
L
-
L
I
D
T
-
P
E
R
L
D
E
L
K
E
I
L
S
E
R
-
F
K
D
V
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
D
---
66
HHSearch
82.11
35%
-93
- C4 -
1NRW
3
YWPJ_BACSU
A:
[4-288]
-
M
K
L
I
A
I
D
L
D
G
T
L
L
N
-
S
K
H
Q
V
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
E
P
-
L
G
I
---
K
T
W
V
I
S
A
N
G
A
V
I
H
D
P
-
E
G
R
--
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
W
L
E
S
-----
E
N
-
Y
Y
Y
E
V
F
T
G
S
--
A
I
Y
T
P
--
Q
N
-------
G
R
E
L
L
D
V
E
L
D
---------------------
R
F
-
R
S
--
A
N
PEA
D
L
S
V
L
K
Q
A
A
E
V
Q
Y
-
S
Q
SG
F
A
Y
I
NS
F
Q
E
L
FEA
D
-
E
---
P
I
--
D
F
--
Y
N
I
L
G
F
S
F
F
-
K
E
K
L
E
A
G
W
K
R
Y
E
-
H
--
A
E
D
L
T
L
V
S
S
A
E
H
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
--
A
--
V
T
L
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----
5
PsiBlast_PDB
82.06
31%
-104
- C4 -
1NF2
3
?
A:
[1-264]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
K
C
Y
-
V
V
F
A
S
G
R
M
L
V
S
T
L
N
--
V
E
-
K
K
Y
F
K
R
T
F
P
T
I
A
Y
N
G
A
I
V
---
Y
L
P
E
EG
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
-----
L
N
-
V
H
W
Q
A
Y
I
D
D
--
V
L
Y
S
E
KD
N
E
-------
E
I
-------
K
---------------------
S
Y
-
A
R
--
H
S
---
N
V
---------
D
Y
-
R
V
--------
E
P
N
L
---
S
-
E
L
V
S
K
M
--
G
T
--
T
K
L
L
-
L
I
D
T
-
P
E
R
L
D
E
L
K
E
I
L
S
E
R
-
F
K
D
V
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
D
---
67
HHSearch
80.69
30%
-102
- C4 -
1NF2
3
?
A:
[1-263]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
-
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
K
K
Y
F
K
R
---
T
F
P
T
I
A
Y
N
G
A
I
V
Y
L
P
-
E
E
G
--
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
-----
L
N
-
V
H
W
Q
A
Y
I
D
D
--
V
L
Y
S
E
--
K
D
-------
N
E
---
E
-
I
-
K
---------------------
S
Y
-
A
R
H
S
N
V
---
D
Y
---------
R
V
E
P
N
--------
L
S
E
L
---
V
-
S
---
K
M
--
G
T
--
T
K
L
L
-
L
I
D
T
-
P
E
R
L
D
E
L
K
E
I
L
S
E
R
-
F
K
D
V
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
----
6
PsiBlast_PDB
79.59
29%
-89
- C4 -
1YMQ
3
?
A:
[2-258]
-
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
-
L
S
E
-
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
--
F
V
G
E
E
--
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
-----
K
G
-
V
P
C
I
F
V
E
E
H
N
I
S
V
C
Q
P
--
N
E
-------
M
V
K
K
---
I
F
Y
---------------------
D
F
-
L
H
--
V
N
---
V
I
---------
P
T
-
V
S
--------
F
E
E
A
---
S
-
N
---
K
E
--
V
I
--
Q
M
T
P
-
F
I
T
E
-
E
E
E
K
E
V
-
L
P
S
I
P
T
C
------
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
4
PsiBlast_PDB
79.59
33%
-82
- C4 -
1NRW
2
YWPJ_BACSU
A:
[5-281]
--
K
L
I
A
I
D
L
D
G
T
L
L
N
-
S
K
H
Q
V
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
E
P
-
L
G
I
K
T
---
W
V
I
S
A
N
G
A
V
I
H
D
P
E
G
R
---
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
W
L
E
S
-----
E
N
-
Y
Y
Y
E
V
F
T
G
S
--
A
I
Y
T
P
--
Q
N
G
R
E
L
L
D
V
E
L
D
R
F
R
-
S
A
N
PEAD
L
S
V
L
K
Q
A
A
E
V
Q
Y
S
Q
SG
F
A
Y
-
I
N
--
S
F
---
Q
E
---------
L
F
-
E
A
--------
D
E
-----
P
-
I
---
D
F
Y
N
I
L
--
G
F
S
F
-
F
K
E
K
----
L
E
A
G
W
K
R
Y
E
H
A
---
E
D
L
T
L
V
S
S
A
E
H
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
--
A
--
V
T
L
T
N
D
E
H
G
V
A
------------
8
PsiBlast_PDB
78.28
29%
-88
- C4 -
2RBK
2
?
A:
[1-258]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
-
L
S
E
-
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
--
F
V
G
E
E
--
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
-----
K
G
-
V
P
C
I
F
V
E
E
H
N
I
S
V
C
Q
P
--
N
E
-------
M
V
K
K
---
I
F
Y
---------------------
D
F
-
L
H
--
V
N
---
V
I
---------
P
T
-
V
S
--------
F
E
E
A
---
S
-
N
---
K
E
--
V
I
--
Q
M
T
P
-
F
I
T
E
-
E
E
E
K
E
V
-
L
P
S
I
P
T
C
------
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
83
Fugue
78.26
29%
-90
- C4 -
1NF2
3
?
A:
[1-267]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
-
R
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
K
K
-
Y
F
K
R
T
--
F
P
T
I
A
Y
N
G
A
I
V
Y
L
P
-
E
E
G
--
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
-----
L
N
-
V
H
W
Q
A
Y
I
D
D
--
V
L
Y
S
E
--
K
D
-------
N
-
E
E
I
K
-
S
Y
A
---------------------
R
H
-
S
N
--
V
D
---
Y
R
---------
V
E
-
P
N
--------
L
S
E
L
---
V
-
S
---
K
M
--
G
T
--
T
K
L
L
-
L
I
D
T
-
P
E
R
L
D
E
L
K
E
I
L
S
E
R
-
F
K
D
V
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
D
C
LD
7
PsiBlast_PDB
78.01
29%
-85
- C4 -
2RB5
2
?
A:
[1-258]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
-
L
S
E
-
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
--
F
V
G
E
E
--
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
-----
K
G
-
V
P
C
I
F
V
E
E
H
N
I
S
V
C
Q
P
--
N
E
-------
M
V
K
K
---
I
F
Y
---------------------
D
F
-
L
H
--
V
N
---
V
I
---------
P
T
-
V
S
--------
F
E
E
A
---
S
-
N
---
K
E
--
V
I
--
Q
M
T
P
-
F
I
T
E
-
E
E
E
K
E
V
-
L
P
S
I
P
T
C
------
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
10
PsiBlast_PDB
77.48
28%
-87
- C4 -
2RAV
2
?
A:
[1-258]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
-
L
S
E
-
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
--
F
V
G
E
E
--
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
-----
K
G
-
V
P
C
I
F
V
E
E
H
N
I
S
V
C
Q
P
--
N
E
-------
M
V
K
K
---
I
F
Y
---------------------
D
F
-
L
H
--
V
N
---
V
I
---------
P
T
-
V
S
--------
F
E
E
A
---
S
-
N
---
K
E
--
V
I
--
Q
M
T
P
-
F
I
T
E
-
E
E
E
K
E
V
-
L
P
S
I
P
T
C
------
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
9
PsiBlast_PDB
77.09
28%
-86
- C4 -
2RAR
2
?
A:
[1-258]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
-
L
S
E
-
L
Q
D
R
N
L
I
D
G
Y
I
T
M
N
G
A
Y
C
--
F
V
G
E
E
--
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
-----
K
G
-
V
P
C
I
F
V
E
E
H
N
I
S
V
C
Q
P
--
N
E
-------
M
V
K
K
---
I
F
Y
---------------------
D
F
-
L
H
--
V
N
---
V
I
---------
P
T
-
V
S
--------
F
E
E
A
---
S
-
N
---
K
E
--
V
I
--
Q
M
T
P
-
F
I
T
E
-
E
E
E
K
E
V
-
L
P
S
I
P
T
C
------
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
12
PsiBlast_PDB
76.27
27%
-95
- C4 -
2QYH
5
?
A:
[4-256]
--
K
I
V
F
F
D
I
D
G
T
L
L
D
-
E
Q
K
Q
L
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
K
Q
-
L
G
I
----
D
S
F
V
S
F
N
G
Q
Y
V
--
V
F
E
G
N
--
V
L
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
-
H
-----
K
N
-
G
H
P
L
V
F
M
D
A
--
E
--
K
M
--
R
A
-------
S
I
G
D
H
P
-
H
I
H
---------------------
V
S
-
M
A
--
S
L
---
K
F
---------
A
H
-
P
P
--------
V
D
P
L
---
Y
Y
E
---
N
K
--
D
I
--
Y
Q
A
L
-
L
F
C
R
-
A
E
E
E
E
P
Y
V
R
N
Y
P
E
------
F
R
F
V
R
W
H
D
V
S
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
--
F
--
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
----
14
PsiBlast_PDB
74.07
28%
-76
- C4 -
3PGV
9
?
A:
[21-284]
-
Y
Q
V
V
A
S
D
L
D
G
T
L
L
S
-
P
D
H
F
L
T
P
Y
A
K
E
T
L
K
L
L
T
A
R
G
I
N
F
V
F
A
T
G
R
H
Y
I
D
V
G
Q
I
R
D
N
-
L
G
I
R
S
---
Y
M
I
T
S
N
G
A
R
V
H
D
S
D
G
Q
Q
--
I
F
A
H
-
N
L
D
R
D
I
A
A
D
L
F
E
I
V
R
N
DPK
I
V
T
N
-
V
Y
R
---
E
D
E
--
W
Y
M
N
R
--
H
R
------------
F
-
F
K
E
---------------------
A
V
-
F
----
N
---
Y
K
---------
L
Y
-
E
P
--------
G
E
L
D
---
P
-
Q
---
G
----
I
--
S
K
V
F
-
F
T
C
E
-
D
H
E
H
L
L
P
L
E
Q
A
M
N
A
R
W
G
D
R
V
N
V
S
F
S
T
L
T
C
L
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
E
L
E
--
V
I
G
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
L
----
68
HHSearch
74.01
28%
-85
- C4 -
3PGV
9
?
A:
[21-284]
-
Y
Q
V
V
A
S
D
L
D
G
T
L
L
S
-
P
D
H
F
L
T
P
Y
A
K
E
T
L
K
L
L
T
A
R
G
I
N
F
V
F
A
T
G
R
H
Y
I
D
V
G
Q
I
R
D
N
-
L
G
I
---
R
S
Y
M
I
T
S
N
G
A
R
V
H
D
S
-
D
G
Q
--
Q
I
F
A
H
N
L
D
R
D
I
A
A
D
L
F
E
I
V
R
N
-----
D
P
K
I
V
T
N
V
Y
R
E
D
--
E
W
Y
M
N
--
R
H
-------
R
------------------------------
F
F
K
E
A
--
V
F
---
N
Y
---------
K
L
-
Y
E
--------
P
G
E
----
L
-
D
---
P
Q
--
G
I
--
S
K
V
F
-
F
T
C
E
D
H
E
H
L
L
P
L
E
Q
A
M
N
A
R
-
W
G
D
R
V
N
V
S
F
S
T
L
T
C
L
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
--
E
L
E
V
I
G
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
L
----