@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0276: (2016-03-14 )
LTKKYLICSDIDGTLLRQDQTVSKKTRDLIQTLEKDGHIFSISTGRMYRSAREVGFQVSSSGHVIASNGSYAAIRDEQLLKTTLEEKAIRSTYDIMSDFDLPLFFFSTNTLFYTKEPPAFFQNLADKSRLDTGHNSFSLVSINEKGIFDENMHQFLNAIVVAEEDASKLTEVRAALNEANGIRVLSSHHNNLEILPANSDKKTAVEALGKHYNIPRERIITFGDGENDIGMLQYAGTGVAMANASDNVKAAANHLTDTNEADGVYKFLKEFIS
Atome Classification :
(20 SA)
.....-....10......-.-.20..--.......30........40.....----...50...------...-..60--..-.......70....--....80...-......90.-...-....100..--....------.--..110....-----------------.-.-.---120..-..-.--..----130---.......140...--.---....150...----....160.--.-....-.170.-....--...--180--.......190..---.....200-----.........210.......220.......230.......240.......250.......260.......270.----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LT
K
K
Y
-
L
I
CSDID
G
T
LLR-Q-DQ-
T
V
--
S
K
K
T
R
D
L
I
Q
T
L
E
KDG
H
I
F
S
IST
G
R
----
M
Y
R
S
A
R
E
V------
G
F
Q
-VSS---SG-
H
V
I
ASNG
S
Y
A
A
I
R
--
D
E
Q
L
L
-
K
T
T
-
L
E
E
K
A
I
R
S
T
-
Y
D
I
-
M
S
DFD--L
P
--
L
F
F
F
------S--T
N
T
L
F
Y
TKE-----------------
P
-
P
-
A
---
F
F
Q
N
L
-
A
D
-
K
--SR----LDT---GHN
S
F
S
L
V
-
S
INE--K---GI
F
D
E
N
M
H
Q
F
----
L
N
A
I
V
VAE--
E
-
D
A
S
K
-
L
T
E
-
V
-
R
A
A
L--NEA--N
G
I
--
R
V
L
S
SHHN
N
L
E
I
---
L
PANSD-------
K
K
T
A
V
E
A
L
G
K
HYNI
P
R
E
R
I
I
T
FGDGEND
I
G
M
L
Q
YAGT
G
V
A
MANASD
N
V
K
A
A
A
NHLTDTNEA
D
G
V
Y
K
F
L
K
E
FIS----
1
PsiBlast_PDB
92.11
27%
-73
- C2 -
3R4C
4
?
A:
[18-265]
----------
D
V
D
G
T
L
L
S
F
E
-
T
H
-
K
V
--
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
----
A
A
S
D
L
H
E
I
------
D
-
A
-
V
P
Y
---
D
G
--
V
I
A
L
N
G
A
E
C
V
L
R
--
D
G
S
V
I
R
K
V
A
-
I
P
A
Q
D
F
R
K
S
-
M
E
L
-
A
R
E
F
D
--
F
A
--
V
A
L
E
------
L
--
N
E
G
V
F
V
N
R
L
-----------------
T
-
P
-
T
---
V
E
Q
I
A
-
G
I
-
V
--
E
------------
H
P
V
P
P
V
V
-
D
I
E
E
-------
M
F
E
R
K
--
E
C
----
C
Q
L
C
F
Y
F
D
--
E
-
E
A
E
Q
--------
K
V
M
--
P
L
L
--
S
G
L
--
S
A
T
R
W
H
P
L
F
A
D
V
---
N
V
A
G
T
S
-------
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
F
V
T
D
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
------
40
HHSearch
90.66
26%
-70
- C2 -
3R4C
4
?
A:
[10-266]
-
H
M
I
K
-
V
L
L
L
D
V
D
G
T
L
L
S
-
F
E
T
H
-
K
V
--
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
----
A
A
S
D
L
H
E
I
------
D
-
A
-
V
P
----
Y
D
-
G
V
I
A
L
N
G
A
E
C
V
L
R
D-
G
S
V
I
R
-
K
V
A
-
I
P
A
Q
D
F
R
K
S
-
M
E
L
-
A
R
E
F
D
--
F
A
--
V
A
L
E
------
L
--
N
E
G
V
F
V
N
R
L
-----------------
T
-
P
-----
T
V
E
Q
I
-
A
G
-
I
V
E
H
P
----
V
P
P
---
V
V
--
D
I
-------------
E
E
M
F
E
-
R
K
E
C
----
C
Q
L
C
F
Y
F
D
--
E
---
E
A
-
E
Q
K
-
V
-
M
P
L
L
--
S
-
G
--
L
S
A
----
T
R
W
H
P
L
F
A
D
V
---
N
V
A
G
T
S
-------
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
F
V
T
D
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
G
-----
48
Fugue
88.64
25%
-73
- C2 -
1NF2
3
?
A:
[1-267]
--
M
Y
R
-
V
F
V
F
D
L
D
G
T
L
L
N
-
D
-
N
L
-
E
I
--
S
E
K
D
R
R
N
I
E
K
L
-
S
R
K
C
Y
V
V
F
A
S
G
R
----
M
L
V
S
T
L
N
V
------
E
K
K
-
Y
F
K
---
R
T
F
P
T
I
A
Y
N
G
A
I
V
Y
L
P
--
E
E
G
V
I
-
L
N
E
K
I
P
P
E
V
A
K
D
I
-
I
E
Y
-
I
K
P
L
N
--
V
H
--
W
Q
A
Y
------
I
--
D
D
V
L
Y
S
E
K
D
-----------------
N
-
E
-
E
---
I
K
S
Y
A
-
R
H
-
S
--
N
V
-------------------
D
Y
R
V
--
E
---
P
N
L
S
E
L
V
S
K
M
----
G
T
T
K
L
L
L
I
--
D
-
T
P
E
R
-
L
D
E
-
L
-
K
E
I
L
--
S
E
R
FK
D
V
V
--
K
V
F
K
S
F
P
T
Y
L
E
I
---
V
P
K
N
V
D
-------
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
DCLD
6
PsiBlast_PDB
86.75
26%
-52
- C2 -
1YMQ
3
?
A:
[8-258]
----------
D
I
D
G
T
L
V
S
F
E
-
T
H
-
R
I
--
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
PKA-
I
I
N
N
L
S
E
L
------
Q
D
R
-
N
L
I
---
D
G
-
Y
-
I
T
M
N
G
A
Y
C
F
V
G
--
E
E
V
I
Y
-
K
S
A
-
I
P
Q
E
E
V
K
A
M
-
A
A
F
-
C
E
K
K
G
--
V
P
--
C
I
F
V
------
E
--
E
----------------------------------------------------------
H
N
-
I
S
V
C
-
Q
P
N
E
M
V
K
---
K
I
F
Y
D
F
L
H
V
N
----
V
I
P
T
V
S
F
E
--
E
-
A
S
N
K
E
V
I
Q
-
M
-
T
P
F
I
--
T
E
E
--
E
E
K
--
E
V
L
P
S
I
-
P
T
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
KGDT
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
16
PsiBlast_PDB
86.12
21%
-68
- C2 -
3FZQ
7
?
A:
[7-269]
------
L
L
I
L
D
I
D
G
T
L
R
D
-
E
-
V
Y
-
G
I
--
P
E
S
A
K
H
A
I
R
L
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
----
S
M
G
T
I
Q
D
D
------
V
L
S
-
L
G
V
---
D
G
-
Y
-
I
A
G
G
G
N
Y
I
Q
Y
H
--
G
E
L
L
Y
-
N
Q
S
-
F
N
Q
R
L
I
K
E
V
-
V
C
L
-
L
K
K
R
E
--
V
A
--
F
S
I
E
------
S
--
Q
E
K
V
F
M
N
Q
K
-----------------
A
-
K
-
E
---
I
F
E
T
-----
M
--
N
Q
----
L
K
G
---
T
N
S
C
I
N
K
Q
-
H
I
Q
E
--
K
---
I
T
Y
E
N
N
I
E
E
Y
KSQD
I
H
K
I
C
L
W
S
--
N
-
E
K
V
--
F
D
E
-
V
-
K
D
I
L
--
Q
D
K
--
M
E
L
AQ
R
D
I
S
S
Q
Y
--
Y
E
I
---
I
Q
K
D
F
H
-------
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
S
I
C
E
D
I
F
D
N
G
I
Y
K
E
L
K
--------
30
HHSearch
86.02
23%
-74
- C2 -
3DAO
1
?
A:
[19-283]
-
G
M
I
K
-
L
I
A
T
D
I
D
G
T
L
V
K
-
D
-
G
S
L
L
I
--
D
P
E
Y
M
S
V
I
D
R
L
I
D
K
G
I
I
F
V
V
C
S
G
R
----
Q
F
S
S
E
F
K
L
------
F
A
P
-
I
K
H
---
K
L
-
L
Y
I
T
D
G
G
T
V
V
R
T
P
--
K
E
I
L
K
-
T
Y
P
-
M
D
E
D
I
W
K
G
M
-
C
R
M
-
V
R
D
E
L
PA
C
D
--
Y
F
A
A
------
T
--
P
D
F
C
F
A
E
D
G
-----------------
G
-
S
-
P
---
I
F
H
L
L
-
R
D
S
Y
G-
F
E
----
M
R
E
---
V
D
--
D
I
-------------
T
R
L
-
D
-
R
N
D
I
----
I
K
F
T
V
F
H
P
D-
K
-
C
E
E
L
-
C
T
P
-
V
F
I
P
A
W
--
N
K
K
--
A
H
L
----
A
A
A
G
K
E
W
V
D
C
---
N
A
K
G
V
S
-------
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
N
A
G
I
S
Y
A
V
S
N
A
R
Q
E
V
I
A
A
A
K
H
T
C
A
P
Y
W
E
N
G
V
L
S
V
L
K
S
F
L
-----
32
HHSearch
85.16
20%
-69
* C2 *
1RLM
3
SUPH_ECOLI
A:
[2-264]
--
A
V
K
-
V
I
V
T
D
M
D
G
T
F
L
N
-
D
-
A
K
-
T
Y
N-
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
----
Q
Y
Y
Q
L
I
S
F
------
F
P
E
-
L
K
D
---
E
I
-
S
F
V
A
E
N
G
A
L
V
Y
E
H
--
G
K
Q
L
F
-
H
G
E
-
L
T
R
H
E
S
R
I
V
-
I
G
E
L
L
K
D
K
Q
--
L
N
--
F
V
A
C
------
G
--
L
Q
S
A
Y
V
S
E
N
-----------------
A
-
P
E
A
---
F
V
A
L
M
A
K
H
-
Y
--
H
R
----
L
K
P
---
V
K
--
D
Y
-------------
Q
E
I
-
D
--
D
V
L
----
F
K
F
S
L
N
L
P
DE
Q
-
I
P
L
V
-
I
D
K
-
L
-
H
V
A
L
--
D
G
I
--
M
K
P
----
V
T
S
G
F
G
F
I
D
L
---
I
I
P
G
L
H
-------
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
----
12
PsiBlast_PDB
84.19
26%
-49
- C2 -
2RAV
2
?
A:
[8-258]
----------
D
I
A
G
T
L
V
S
F
E
-
T
H
-
R
I
--
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
PKA-
I
I
N
N
L
S
E
L
------
Q
D
R
-
N
L
I
---
D
G
-
Y
-
I
T
M
N
G
A
Y
C
F
V
G
--
E
E
V
I
Y
-
K
S
A
-
I
P
Q
E
E
V
K
A
M
-
A
A
F
-
C
E
K
K
G
--
V
P
--
C
I
F
V
------
E
--
E
----------------------------------------------------------
H
N
-
I
S
V
C
-
Q
P
N
E
M
V
K
---
K
I
F
Y
D
F
L
H
V
N
----
V
I
P
T
V
S
F
E
--
E
-
A
S
N
K
E
V
I
Q
-
M
-
T
P
F
I
--
T
E
E
--
E
E
K
--
E
V
L
P
S
I
-
P
T
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
KGDT
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
31
HHSearch
83.87
26%
-64
- C2 -
1RKQ
2
YIDA_ECOLI
A:
[3-270]
-
L
A
I
K
-
L
I
A
I
D
M
D
G
T
L
L
L
-
P
-
D
H
-
T
I
--
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
----
P
Y
A
G
V
H
N
Y
------
L
K
E
-
L
H
M
EQP
G
D
-
Y
C
I
T
Y
N
G
A
L
V
Q
K
A
AD
G
S
T
V
A
-
Q
T
A
-
L
S
Y
D
D
Y
R
F
L
-
E
K
L
-
S
R
E
V
G
--
S
H
--
F
H
A
L
------
D
--
R
T
T
L
Y
T
A
N
R
-----------------
D
-
I
-
S
---
Y
Y
T
V
H
-
E
S
-
F
--
V
A
------
T
---
I
P
--
L
V
F
----
C
E
--
A
---
E
K
M
-
D
P
N
T
Q
F
----
L
K
V
M
M
I
D
E
P
A
I
-
L
D
Q
A
-
I
A
R
-
I
-
P
Q
E
V
--
K
E
K
--
Y
T
V
----
L
K
S
A
P
Y
F
L
E
I
---
L
D
K
R
V
N
-------
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
-----
11
PsiBlast_PDB
83.77
26%
-48
- C2 -
2RAR
2
?
A:
[8-258]
----------
D
I
A
G
T
L
V
S
F
E
-
T
H
-
R
I
--
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
PKA-
I
I
N
N
L
S
E
L
------
Q
D
R
-
N
L
I
---
D
G
-
Y
-
I
T
M
N
G
A
Y
C
F
V
G
--
E
E
V
I
Y
-
K
S
A
-
I
P
Q
E
E
V
K
A
M
-
A
A
F
-
C
E
K
K
G
--
V
P
--
C
I
F
V
------
E
--
E
----------------------------------------------------------
H
N
-
I
S
V
C
-
Q
P
N
E
M
V
K
---
K
I
F
Y
D
F
L
H
V
N
----
V
I
P
T
V
S
F
E
--
E
-
A
S
N
K
E
V
I
Q
-
M
-
T
P
F
I
--
T
E
E
--
E
E
K
--
E
V
L
P
S
I
-
P
T
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
GDT
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
8
PsiBlast_PDB
83.52
26%
-50
- C2 -
2RBK
2
?
A:
[8-258]
----------
D
I
D
G
T
L
V
S
F
E
-
T
H
-
R
I
--
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
PKA-
I
I
N
N
L
S
E
L
------
Q
D
R
-
N
L
I
---
D
G
-
Y
-
I
T
M
N
G
A
Y
C
F
V
G
--
E
E
V
I
Y
-
K
S
A
-
I
P
Q
E
E
V
K
A
M
-
A
A
F
-
C
E
K
K
G
--
V
P
--
C
I
F
V
------
E
--
E
----------------------------------------------------------
H
N
-
I
S
V
C
-
Q
P
N
E
M
V
K
---
K
I
F
Y
D
F
L
H
V
N
----
V
I
P
T
V
S
F
E
--
E
-
A
S
N
K
E
V
I
Q
-
M
-
T
P
F
I
--
T
E
E
--
E
E
K
--
E
V
L
P
S
I
-
P
T
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
KGDT
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
7
PsiBlast_PDB
83.16
26%
-49
- C2 -
2RB5
2
?
A:
[8-258]
----------
D
I
D
G
T
L
V
S
F
E
-
T
H
-
R
I
--
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
PKA-
I
I
N
N
L
S
E
L
------
Q
D
R
-
N
L
I
---
D
G
-
Y
-
I
T
M
N
G
A
Y
C
F
V
G
--
E
E
V
I
Y
-
K
S
A
-
I
P
Q
E
E
V
K
A
M
-
A
A
F
-
C
E
K
K
G
--
V
P
--
C
I
F
V
------
E
--
E
----------------------------------------------------------
H
N
-
I
S
V
C
-
Q
P
N
E
M
V
K
---
K
I
F
Y
D
F
L
H
V
N
----
V
I
P
T
V
S
F
E
--
E
-
A
S
N
K
E
V
I
Q
-
M
-
T
P
F
I
--
T
E
E
--
E
E
K
--
E
V
L
P
S
I
-
P
T
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
KGDT
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
------
3
PsiBlast_PDB
83.05
26%
-75
- C2 -
4DW8
4
?
A:
[4-261]
---
K
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
-
K
K
-
E
I
--
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
PTYG
I
V
P
L
A
N
E
L
RMNEFG
G
F
I
-
L
S
Y
---
N
G
-
G
E
I
I
N
W
E
S
-------
K
E
M
M
Y
-
E
N
V
-
L
P
N
E
V
V
P
V
L
-
Y
E
C
-
A
R
T
N
H
--
L
S
--
I
L
T
Y
D
GA
E
I
V
T
--
E
N
S
L
D
P
Y
V
Q
-----------------
K
-
E
-
A
---
F
L
N
K
M
-
A
I
-
R
--
E
------------
T
N
D
F
----------------
L
T
D
I
T
L
P
V
----
A
K
C
L
I
V
G
-----
D
A
G
K
-
L
I
P
-
V
-
E
S
E
L
C
I
R
L
Q
--
G
K
I
--
N
V
F
R
S
E
P
Y
F
L
E
L
---
V
P
Q
G
I
D
-------
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
I
T
L
T
N
D
E
D
G
V
-------------
13
PsiBlast_PDB
82.78
26%
-72
- C2 -
3NIW
2
?
A:
[4-261]
--
K
Y
K
-
L
I
V
L
D
L
D
G
T
L
T
N
-
S
-
K
K
-
E
I
--
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
PTYG
I
V
P
L
A
N
E
L
RMNEFG
G
F
I
-
L
S
Y
---
N
G
-
G
E
I
I
N
W
E
S
-------
K
E
M
M
Y
-
E
N
V
-
L
P
N
E
V
V
P
V
L
-
Y
E
C
-
A
R
T
N
H
--
L
S
--
I
L
T
Y
D
GA
E
I
V
T
--
E
N
S
L
D
P
Y
V
Q
-----------------
K
-
E
-
A
---
F
L
N
K
M
-
A
I
-
R
--
E
------------
T
N
D
F
----------------
L
T
D
I
T
L
P
V
----
A
K
C
L
I
V
G
-----
D
A
G
K
-
L
I
P
-
V
-
E
S
E
L
C
I
R
L
Q
--
G
K
I
--
N
V
F
R
S
E
P
Y
F
L
E
L
---
V
P
Q
G
I
D
-------
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
I
T
L
T
N
D
E
D
G
V
-------------
36
HHSearch
82.68
24%
-73
- C2 -
1NF2
3
?
A:
[1-262]
--
M
Y
R
-
V
F
V
F
D
L
D
G
T
L
L
N
-
D
-
N
L
-
E
I
--
S
E
K
D
R
R
N
I
E
K
L
S
R
-
K
C
Y
V
V
F
A
S
G
R
----
M
L
V
S
T
L
N
V
------
E
K
K
Y
F
K
R
---
T
F
-
P
T
I
A
Y
N
G
A
I
V
Y
L
P
E-
E
G
V
I
L
-
N
E
K
-
I
P
P
E
V
A
K
D
I
-
I
E
Y
-
I
K
P
L
N
--
V
H
--
W
Q
A
Y
------
I
--
D
D
V
L
Y
S
E
K
D
-----------------
N
-
E
-
E
I
K
S
Y
A
R
H
S
N
V
D
-
Y
--
R
V
----------
E
P
--
N
L
-------------
S
E
L
-
V
S
K
M
G
T
----
T
K
L
L
L
I
D
T
P
E
R
-
L
D
E
L
-
K
E
I
-
L
-
S
E
R
F
--
K
D
V
--
V
K
V
----
F
K
S
F
P
T
Y
L
E
I
---
V
P
K
N
V
D
-------
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
-----
15
PsiBlast_PDB
82.46
21%
-66
- C2 -
3DNP
1
YHAX_BACSU
A:
[6-273]
---
K
Q
-
L
L
A
L
N
I
D
G
A
L
L
R
-
S
-
N
G
-
K
I
--
H
Q
A
T
K
D
A
I
E
Y
V
K
K
K
G
I
Y
V
T
L
V
T
N
R
----
H
F
R
S
A
Q
K
I
------
A
K
S
-
L
K
L
---
D
A
-
K
L
I
T
H
S
G
A
Y
I
A
E
K
I-
D
A
P
F
F
-
E
K
R
-
I
S
D
D
H
T
F
N
I
-
V
Q
V
-
L
E
S
Y
Q
--
C
N
--
I
R
L
L
------
H
--
E
K
Y
S
I
G
N
K
K
---------------------
K
---
V
N
S
N
L
-
L
G
-
K
--
A
L
----
I
H
P
---
S
D
P
I
F
Y
P
V
-
Q
F
V
E
--
S
L
S
D
L
L
M
D
E
P
V
S
A
P
----
V
I
E
V
Y
T
E
H
--
D
-
I
Q
H
D
-
I
T
E
T
I
-
T
K
A
F
--
P
A
V
--
D
V
I
--
R
V
---
N
D
E
K
L
N
I
---
V
P
K
G
V
S
-------
K
E
A
G
L
A
L
V
A
S
E
L
G
L
S
M
D
D
V
V
A
I
G
H
Q
Y
D
D
L
P
M
I
E
L
A
G
L
G
V
A
M
G
N
A
V
P
E
I
K
R
K
A
D
W
V
T
R
S
N
D
E
Q
G
V
A
Y
M
M
K
E
Y
------
14
PsiBlast_PDB
82.32
25%
-61
- C2 -
3L7Y
1
?
A:
[39-301]
------
V
I
A
T
D
M
D
G
T
F
L
N
-
S
-
K
G
-
S
Y
D
H
N
R
F
Q
R
I
L
K
Q
L
Q
E
R
D
I
R
-
F
V
V
A
S
S
N
----
P
Y
R
Q
L
R
E
H
------
F
P
D
-
C
H
E
---
Q
L
-
T
F
V
G
E
N
G
A
N
I
I
S
K
--
N
Q
S
L
I
-
E
V
F
-
Q
Q
R
E
D
I
A
S
I
I
Y
F
I
-
E
E
K
Y
P
--
Q
A
--
V
I
A
L
------
S
--
G
E
K
K
G
Y
L
K
K
-----------------
G
-
V
-
S
E
N
-
I
V
K
M
L
-
S
P
-
F
--
F
P
----
V
L
E
---
L
V
N
S
F
S
P
L
-
P
-------------
E
R
F
F
K
L
------
T
L
Q
V
K
E
--
E
-
E
S
A
Q
-
I
M
K
-
A
-
I
A
D
Y
--
K
T
S
--
Q
R
L
--
V
G
T
A
S
G
F
G
Y
I
D
I
---
I
T
K
G
L
H
-------
K
G
W
A
L
Q
Q
L
L
K
R
W
N
F
T
S
D
H
L
M
A
F
G
D
G
G
N
D
I
E
M
L
K
L
A
K
Y
S
Y
A
M
A
N
A
P
K
N
V
K
A
A
A
N
Y
Q
A
K
S
N
D
E
S
G
V
L
D
V
I
D
N
Y
L
A
----
37
HHSearch
81.67
21%
-68
- C2 -
3L7Y
1
?
A:
[36-300]
--
S
V
K
-
V
I
A
T
D
M
D
G
T
F
L
N
-
S
-
K
G
-
S
Y
D-
H
N
R
F
Q
R
I
L
K
Q
L
Q
E
R
D
I
R
F
V
V
A
S
S
N
----
P
Y
R
Q
L
R
E
H
------
F
P
D
-
C
H
E
---
Q
L
-
T
F
V
G
E
N
G
A
N
I
I
S
K
--
N
Q
S
L
I
-
E
V
F
-
Q
Q
R
E
D
I
A
S
I
-
I
Y
F
-
I
E
E
K
Y
--
P
Q
A
V
I
A
L
S
------
G
--
E
K
K
G
Y
L
K
K
G
-----------------
V
S
E
-
N
---
I
V
K
M
L
-
S
P
-
F
F-
P
V
----
L
E
L
---
V
N
--
S
F
-------------
S
P
L
-
P
--
E
R
F
----
F
K
L
T
L
Q
V
K
EE
E
-
S
A
Q
I
-
M
K
A
-
I
-
A
D
Y
K
T-
S
Q
R
--
L
V
G
----
T
A
S
G
F
G
Y
I
D
I
---
I
T
K
G
L
H
-------
K
G
W
A
L
Q
Q
L
L
K
R
W
N
F
T
S
D
H
L
M
A
F
G
D
G
G
N
D
I
E
M
L
K
L
A
K
Y
S
Y
A
M
A
N
A
P
K
N
V
K
A
A
A
N
Y
Q
A
K
S
N
D
E
S
G
V
L
D
V
I
D
N
Y
L
-----
5
PsiBlast_PDB
81.57
26%
-45
- C2 -
1NRW
3
YWPJ_BACSU
A:
[6-288]
------
L
I
A
I
D
L
D
G
T
L
L
N
-
S
-
K
H
-
Q
V
--
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
----
A
H
F
D
V
M
S
I
------
F
E
P
-
L
G
I
---
K
T
-
W
V
I
S
A
N
G
--
A
V
I
H
--
D
P
E
G
R
-
L
Y
H
-
H
E
T
I
D
K
K
R
A
-
Y
D
I
-
L
S
W
L
E
--
S
E
--
N
Y
Y
Y
------
E
V
F
T
G
S
A
I
Y
T
P
Q
N
G
R
E
L
L
D
V
E
L
D
R
F
R
S
A
N
P
-
E
-
A
---
D
L
S
V
L
-
K
Q
-
A
--
A
E
----
V
Q
Y
---
S
Q
S
G
F
A
Y
I
N
S
F
Q
E
--
L
---
F
E
A
D
E
P
I
-
D
F
----
Y
N
-
I
L
G
F
S
--
F
-
F
K
E
K
-
L
E
A
-
G
-
W
K
R
Y
--
E
H
A
--
E
D
L
--
T
L
V
S
S
A
E
H
N
F
E
L
---
S
S
R
K
A
S
-------
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
V
T
L
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----
28
HHSearch
81.45
19%
-59
- C2 -
3FZQ
7
?
A:
[4-271]
--
L
Y
K
-
L
L
I
L
D
I
D
G
T
L
R
D
-
E
-
V
Y
-
G
I
--
P
E
S
A
K
H
A
I
R
L
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
----
S
M
G
T
I
Q
D
D
------
V
L
S
-
L
G
V
----
D
-
G
Y
I
A
G
G
G
N
Y
I
Q
Y
H
--
G
E
L
L
Y
-
N
Q
S
-
F
N
Q
R
L
I
K
E
V
-
V
C
L
-
L
K
K
R
E
--
V
A
--
F
S
I
E
------
S
--
Q
E
K
V
F
M
N
Q
K
-----------------
A
-
K
-
E
---
I
F
E
T
M
-
N
Q
-
L
--
K
G
TNSC
I
N
K
QHI
Q
E
K
I
T
Y
----
E
N
N
--
I
---
E
E
Y
-
K
-
S
Q
D
I
----
H
K
I
C
L
W
S
N
E
-
K
V
F
D
E
V
-
K
D
I
-
L
-
Q
D
K
M
--
E
----
L
A
Q
----
R
D
I
S
S
Q
Y
Y
E
I
---
I
Q
K
D
F
H
-------
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
S
I
C
E
D
I
F
D
N
G
I
Y
K
E
L
K
R
R
------