@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0277: (2016-03-14 )
MGNLNWAILGPGSIAHEFAEGMRGMNREIYAVGARSLEKGQAFASQYGIENVYDDFDKMLADPAIDVVYIATPHSNHYEFIMKSLHNGKHVLAEKAITVSSKELNEINVLAKEKGLIVKEAMTIFHMPLYKKLREIVESGAIGKLKIIQVAFGSAKEKDPKNRFYNMDLAGGALLDIGTYALSFARYFLSETPDEVLTTMKKFETGVDEQSGILLKNNEEELAVVSLSFRAKMPKRGVIACEEGFITVDEYPRASRATVTHTATGKVEEIEVGETSKALEYEITAMEESVATGENMTYQLTNDVIAIMSDVRTQWGIKFPFEK
Atome Classification :
(20 SA)
----------------------------.........10....-.-.-..20..-.-.---..----..30........40....-..-..50-..----..--.....60........70........80........90........100.......110..-.-....120.......130.......140.....-..150..-...----.-.160-..-.---..-.--.170........180..-.....-190-.......200--.------..-----...-.210.......220......--.230-.--.......240.......250-.---..-.-----..--.260.---..-.-.---.---.270.--..-----....----..280.......290.--.----.----..---------..300.......310.......320.------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------MGNL
N
W
A
I
LG
P
G
S
I
A
-
H
-
E
-
F
A
E
G
M
R-G-M---NR----
E
I
Y
A
V
G
A
RSLE
K
G
Q
A
F
A
S
-QY-G
I
E
--
N
V
----
Y
D
--
D
F
D
K
M
LADPA
I
D
V
V
Y
I
ATPHS
N
H
Y
E
F
I
M
K
S
LHNG
K
H
V
L
A
EK
A
I
TVSSKE
L
N
E
I
N
V
L
A
KEK-G-
L
I
V
K
E
A
M
T
I
F
H
M
P
L
Y
K
K
L
R
E
I
V
ESGAI
G
K
L
K
I
-
I
Q
V
AFGS-AKE----K-DPKN-RF-Y---NM-D--LA-G
G
A
L
L
D
I
G
T
Y
A
L
S
F
-
A
R
Y
F
L
-SET-
P
D
E
V
L
T
T
M
K
K
--
F
------ET-----GVD-EQS
G
I
L
L
KNNEE
E
L
A
V
V
S
L
S
--
F
RA--K--MPKR
G
V
I
A
CEE
G
F
I
TVDEYP-R---AS-R-----
A
T
--
V
T
HTA---TG-
K
-
V
---
E
---
E
I
--E--VG-----ETSK----
A
L
E
Y
E
I
T
A
M
E
E
SVATG--E----
N
----
M
T
---------
Y
Q
L
T
N
D
V
I
A
I
M
S
D
V
R
T
QWGIKFPFEK------
81
Fugue
94.38
26%
-98
- C2 -
2O4U
9
DHDH_MACFA
X:
[2-332]
------------------------------
A
L
R
W
G
I
V
S
V
G
L
I
S
-
S
-
D
-
F
T
A
V
L
Q
-
T
-
L
---
P
R
SEH-
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
-
K
H
-
D
I
P
--
K
A
----
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
V
-
A
R
A
E
F
G
---
K
N
----
L
-
T
H
V
P
-
R
A
-
V
---
D
W
-
A
--
Q
A
-
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
-
I
S
M
V
F
G
G
Q
K
-
P
E
K
I
S
V
M
G
R
R
--
H
------
E
T
-----
G
V
D
-
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
T
C
S
--
I
T
A
--
Q
--
L
S
N
T
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
P
C
-
W
---
C
P
-
T
-----
E
L
--
V
V
K
G
E
---
H
K
-
E
-
F
---
L
---
L
P
--
P
--
V
P
KNCNF
D
N
G
A
----
G
M
S
Y
E
A
K
H
V
R
E
C
L
R
K
G
--
L
KESP
V
----
I
P
---------
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
G
V
T
F
P
Q
D
-------
62
HHSearch
93.25
25%
-94
- C2 -
3OHS
10
DHDH_MACFA
X:
[2-332]
------------------------------
A
L
R
W
G
I
V
S
V
G
L
I
S
-
S
-
D
-
F
T
A
V
L
Q
-
T
-
L
PRS
E
H
----
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
-
K
H
-
D
I
P
--
K
A
----
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
V
-
A
R
A
E
F
G
K
-
N
L
T
----
H
---
V
P
-
R
A
-
V
---
D
W
-
A
--
Q
A
-
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
-
I
S
M
V
F
-
G
G
Q
K
P
E
K
I
S
V
M
G
R
R
--
H
------
E
T
-----
G
V
D
-
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
T
C
S
--
I
T
A
--
Q
--
L
S
N
T
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
P
C
W
C
---
P
T
-
E
-----
L
V
--
V
K
G
E
H
---
K
E
-
F
L
L
---
P
PVP
K
N
--
C
--
N
F
-----
D
N
G
A
----
G
M
S
Y
E
A
K
H
V
R
E
C
L
R
K
G
L-
K
ES--
P
V---
I
P
---------
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
G
V
T
F
P
Q
D
-------
64
HHSearch
91.40
30%
-100
- C2 -
3EVN
-
?
A:
[5-322]
------------------------------
K
V
R
Y
G
V
V
S
T
A
K
V
A
-
P
-
R
-
F
I
E
G
V
R
-
L
-
A
G--
N
G
----
E
V
V
A
V
S
S
R
T
L
E
S
A
Q
A
----
K
Y
-
H
L
P
--
K
A
----
Y
D
--
K
L
E
D
M
L
A
D
E
S
I
D
V
I
Y
V
A
T
I
N
Q
D
H
Y
K
V
A
K
A
A
L
L
A
G
K
H
V
L
V
E
K
P
F
T
L
T
Y
D
Q
A
N
E
L
F
A
L
A
E
S
C
-
N
-
L
F
L
M
E
A
Q
K
S
V
F
I
P
M
T
Q
V
I
K
K
L
L
A
S
G
E
I
G
E
V
I
S
-
I
S
S
T
T
A
Y
-
P
N
I
------
D
H
V
T
-
W
F
-
R
---
E
L
-
E
--
L
G
-
G
G
T
V
H
F
M
A
P
Y
A
L
S
Y
-
L
Q
Y
L
F
-
D
A
T
-
I
T
H
A
S
G
T
A
T
F
--
P
------
K
G
-----
Q
S
D
-
S
Q
S
K
L
L
L
Q
L
S
N
G
V
L
V
D
I
F
L
T
--
T
R
L
--
N
--
L
P
H
E
M
I
I
Y
G
T
E
G
R
L
I
I
P
H
F
W
-
K
---
T
T
-
H
-----
A
K
--
L
V
R
N
D
---
T
S
---
A
---
R
---
T
I
--
Q
--
V
------
D
M
V
S
----
D
F
E
K
E
A
Y
H
V
S
Q
M
I
L
E
G
Q-
R
VS--
H
I---
M
T
---------
P
Q
L
T
L
S
G
V
K
I
I
E
D
L
Y
R
S
W
G
K
E
-----------
1
PsiBlast_PDB
91.01
29%
-96
- C2 -
3EVN
-
?
A:
[5-320]
------------------------------
K
V
R
Y
G
V
V
S
T
A
K
V
A
-
P
-
R
-
F
I
E
G
V
R
L
A
-
G
---
N
G
----
E
V
V
A
V
S
S
R
T
L
E
S
A
Q
A
----
K
Y
-
H
L
P
--
K
A
----
Y
D
--
K
L
E
D
M
L
A
D
E
S
I
D
V
I
Y
V
A
T
I
N
Q
D
H
Y
K
V
A
K
A
A
L
L
A
G
K
H
V
L
V
E
K
P
F
T
L
T
Y
D
Q
A
N
E
L
F
A
L
A
E
S
C
-
N
-
L
F
L
M
E
A
Q
K
S
V
F
I
P
M
T
Q
V
I
K
K
L
L
A
S
G
E
I
G
--
E
V
-
I
S
I
S
S
T
T
-
A
Y
P
----
N
I
D
H
V
T
-
W
F
-
R
---
E
L
-
E
--
L
G
-
G
G
T
V
H
F
M
A
P
Y
A
L
S
Y
-
L
Q
Y
L
F
-
D
A
T
-
I
T
H
A
S
G
T
A
T
F
--
P
------
K
G
-----
Q
S
D
-
S
Q
S
K
L
L
L
Q
L
S
N
G
V
L
V
D
I
F
L
T
--
T
R
L
--
N
--
L
P
H
E
M
I
I
Y
G
T
E
G
R
L
I
I
P
H
F
W
-
K
---
T
T
-
H
-----
A
K
--
L
V
R
N
D
---
T
S
---
A
---
R
---
T
I
--
Q
--
V
D
-----
M
V
S
D
-----
F
E
K
E
A
Y
H
V
S
Q
M
I
L
E
G
--
Q
----
R
VSHI
M
T
---------
P
Q
L
T
L
S
G
V
K
I
I
E
D
L
Y
R
S
W
G
-------------
60
HHSearch
86.01
22%
-87
- C2 -
1ZH8
7
?
A:
[16-337]
----------------------------
L
R
K
I
R
L
G
I
V
G
C
G
I
A
A
-
R
-
E
L
H
L
P
A
L
K
-
N
-
L
SH-
L
F
----
E
I
T
A
V
T
S
R
T
R
S
H
A
E
E
F
A
K
-
M
V
-
G
N
P
--
A
V
----
F
D
--
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
-
K
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
I
G
D
P
V
F
-
M
N
W
Q
I
W
V
-
G
M
D
ENNK
Y
-
V
H
T
D
-
W
R
-
K
---
K
P
-
K
--
H
V
-
G
G
F
L
S
D
G
G
V
H
H
A
A
A
-
M
R
L
I
L
-
G
E
I
--
E
W
I
S
A
V
A
K
D
LS
P
------
L
L
-----
G
G
M
-
D
F
L
S
S
I
F
E
F
E
N
G
T
V
G
N
Y
T
I
S
--
Y
S
L
--
K
--
G
N
E
R
F
E
I
T
G
T
K
G
K
I
S
I
S
W
D
---------
K
-----
I
V
--
L
N
E
-----
E
------------
E
M
--
K
---
V
-----
P
Q
E
N
----
S
Y
Q
K
E
F
E
D
F
Y
Q
V
V
A
E
G
K-
P
N---
D
L---
G
S
---------
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
F
V
S
-------
65
HHSearch
83.92
21%
-93
- C2 -
3RC1
7
?
A:
[26-349]
-----------------------------
N
P
I
R
V
G
V
I
G
C
A
D
I
A
-
W
-
R
R
A
L
P
A
L
E
-
A
-
E
P--
L
T
----
E
V
T
A
I
A
S
R
R
W
D
R
A
K
R
F
T
E
-
R
F
-
G
G
---
E
P
----
V
E
--
G
Y
P
A
L
L
E
R
D
D
V
D
A
V
Y
V
P
L
P
A
V
L
H
A
E
W
I
D
R
A
L
R
A
G
K
H
V
L
A
E
K
P
L
T
T
D
R
P
Q
A
E
R
L
F
A
V
A
R
E
R
-
G
-
L
L
L
M
E
N
F
M
F
L
H
H
P
Q
H
R
Q
V
A
D
M
L
D
E
G
V
I
G
E
I
R
S
-
F
A
A
S
F
T
I
-
P
P
K
----
P
--
Q
G
D
-
I
R
-
Y
---
Q
A
-
D
--
V
G
-
G
G
A
L
L
D
I
G
V
Y
P
I
R
A
-
A
G
L
F
L
-
G
A
D
-
L
E
F
V
G
A
V
L
R
H
E
-
R
------
D
R
-----
D
V
V
-
V
G
G
N
A
L
L
T
T
R
Q
G
V
T
A
Q
L
T
F
G
--
M
E
H
--
A
--
Y
T
N
N
Y
E
F
R
G
S
T
G
R
L
W
M
N
R
V
F
-
T
---
P
P
A
T
-----
Y
Q
P
V
V
H
I
E
R
---
Q
D
-
H
-
A
---
E
---
Q
F
--
V
---
L
-----
P
A
H
D
----
Q
F
A
K
S
I
R
A
F
A
Q
A
V
L
S
G
E-
H
----
P
R
---
E
W
---------
S
E
D
S
L
R
Q
A
S
L
V
D
A
V
R
T
G
A
R
D
I
Y
F
---------
3
PsiBlast_PDB
83.65
30%
-106
- C3 -
2O4U
8
DHDH_MACFA
X:
[3-234]
-------------------------------
L
R
W
G
I
V
S
V
G
L
I
S
-
S
-
D
-
F
T
A
V
L
Q
-
T
-
L
---
P
R
SEH-
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
-
K
H
-
D
I
P
--
K
A
----
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
V
-
A
R
A
E
F
G
K
-
N
L
T
----
H
-
V
P
---
R
A
-
V
---
D
W
-
A
--
Q
A
-
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
-
G
Q
K
-
P
E
K
I
S
V
M
G
R
R
--
H
------
E
T
-----
G
V
D
-
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
T
C
S
--
I
T
A
--
Q
--
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
84
Fugue
82.74
21%
-87
- C2 -
1OFG
2
GFO_ZYMMO
A:
[1-381]
ATLP
A
G
A
S
Q
VPT
T
P
A
G
R
P
MPYAI
R
P
M
P
E
D
R
R
F
G
Y
A
I
V
G
L
G
K
Y
A
-
L
N
Q
-
I
L
P
G
F
A
--------
G
CQHS
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
-
E
-
Y
G
V
D
--
P
R
KIYD
Y
S
--
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
-
V
T
T
D
N
S
D
-
V
M
D
----
Q
-
N
D
P
A
-
Q
Q
-
W
RLR
R
E
-
L
--
A
G
-
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
-
T
R
Y
L
L
-
G
E
E
-
P
I
E
V
R
A
Y
T
Y
S
--
D
------
P
N
DERFV
E
V
E
-
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
S
H
G
A
S
S
YS--
T
--
T
--
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
A
T
-
G
---
Y
Y
-
Q
-----
N
L
--
I
S
V
Q
T
---
P
G
-
H
-
A
---
N
---
Q
S
--
M
--
M
P
-----
Q
F
I
M
PANN
Q
F
S
A
Q
L
D
H
L
A
E
A
V
I
N
N
--
K
-----------PVRSP
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
N
T
D
W
G
Y
V
R
Q
GGY
5
PsiBlast_PDB
82.65
30%
-104
- C3 -
3OHS
9
DHDH_MACFA
X:
[3-234]
-------------------------------
L
R
W
G
I
V
S
V
G
L
I
S
-
S
-
D
-
F
T
A
V
L
Q
-
T
-
L
---
P
R
SEH-
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
-
K
H
-
D
I
P
--
K
A
----
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
V
-
A
R
A
E
F
G
K
-
N
L
T
----
H
-
V
P
---
R
A
-
V
---
D
W
-
A
--
Q
A
-
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
-
G
Q
K
-
P
E
K
I
S
V
M
G
R
R
--
H
------
E
T
-----
G
V
D
-
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
T
C
S
--
I
T
A
--
Q
--
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.29
30%
-104
- C3 -
2O48
6
DHDH_MACFA
X:
[3-234]
-------------------------------
L
R
W
G
I
V
S
V
G
L
I
S
-
S
-
D
-
F
T
A
V
L
Q
-
T
-
L
---
P
R
SEH-
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
-
K
H
-
D
I
P
--
K
A
----
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
V
-
A
R
A
E
F
G
K
-
N
L
T
----
H
-
V
P
---
R
A
-
V
---
D
W
-
A
--
Q
A
-
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
-
G
Q
K
-
P
E
K
I
S
V
M
G
R
R
--
H
------
E
T
-----
G
V
D
-
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
T
C
S
--
I
T
A
--
Q
--
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.26
30%
-103
- C3 -
2POQ
6
DHDH_MACFA
X:
[3-234]
-------------------------------
L
R
W
G
I
V
S
V
G
L
I
S
-
S
-
D
-
F
T
A
V
L
Q
-
T
-
L
---
P
R
SEH-
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
-
K
H
-
D
I
P
--
K
A
----
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
V
-
A
R
A
E
F
G
K
-
N
L
T
----
H
-
V
P
---
R
A
-
V
---
D
W
-
A
--
Q
A
-
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
-
G
Q
K
-
P
E
K
I
S
V
M
G
R
R
--
H
------
E
T
-----
G
V
D
-
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
T
C
S
--
I
T
A
--
Q
--
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
80.77
17%
-90
- C2 -
3MZ0
7
IOLG_BACSU
A:
[1-326]
-----------------------------
M
S
L
R
I
G
V
I
G
T
G
A
I
G
-
K
-
E
-
H
I
N
R
I
T
-
N
K
L
S--
G
A
----
E
I
V
A
V
T
D
V
N
Q
E
A
A
Q
K
V
V
E
-
Q
Y
-
Q
L
N
A
-
T
V
----
Y
P
--
N
D
D
S
L
L
A
D
E
N
V
D
A
V
L
V
T
S
W
G
P
A
H
E
S
S
V
L
K
A
I
K
A
Q
K
Y
V
F
C
E
K
P
L
A
T
T
A
E
G
C
M
R
I
V
E
E
E
I
K
V
-
G
K
R
L
V
Q
V
G
F
M
R
R
Y
D
S
G
Y
V
Q
L
K
E
A
L
D
N
H
V
I
G
E
P
L
M
-
I
H
C
A
H
R
N
-
P
T
V
-------
G
D
N
-
Y
------------
T
T
-
D
M
A
V
V
D
T
L
V
H
E
I
D
V
-
L
H
W
L
V
-
N
D
D
-
Y
E
S
V
Q
V
I
Y
P
K
--
K
SKNA--
L
P
-----
H
L
K
-
D
P
Q
I
V
V
I
E
T
K
G
G
I
V
I
N
A
E
I
Y
--
V
N
C
--
K
YG
Y
D
I
Q
C
E
I
V
G
E
D
G
I
I
K
L
P
E
P
S
--------
S
-----
I
S
--
L
R
K
E
G
---
R
F
-
S
-
T
---
D
---
I
L
M-
D
W-
Q
R
-----
R
F
V
A
----
A
Y
D
V
E
I
Q
D
F
I
D
S
I
Q
K
K
GE
V
----
S
G---
P
T
---------
A
W
D
G
Y
I
A
A
V
T
T
D
A
C
V
K
A
Q
E
S
G
Q
K
E
K
-------
61
HHSearch
80.00
18%
-84
- C2 -
3CEA
1
?
A:
[6-343]
----------------------------
R
K
P
L
R
A
A
I
I
G
L
G
R
L
G
-
E
-
R
-
H
A
R
H
L
V
-
N
K
I
Q--
G
V
----
K
L
V
A
A
C
A
L
D
S
N
Q
L
E
W
A
K
N
-
E
L
-
G
V
E
--
T
T
----
Y
T
--
N
Y
K
D
M
I
D
T
E
N
I
D
A
I
F
I
V
A
P
T
P
F
H
P
E
M
T
I
Y
A
M
N
A
G
L
N
V
F
C
E
K
P
L
G
L
D
F
N
E
V
D
E
M
A
K
V
I
K
S
H
P
N
-
Q
I
F
Q
S
G
F
M
R
R
Y
D
D
S
Y
R
Y
A
K
K
I
V
D
N
G
D
I
G
K
I
I
Y
-
M
R
G
Y
G
I
D
-
P
I
S
----
G
-
M
E
S
F
T
K
F
-
A
---
T
E
-
A
--
D
S
-
G
G
I
F
V
D
M
N
I
H
D
I
D
L
-
I
R
W
F
T
-
G
Q
D
-
P
V
Q
A
Y
G
L
T
S
N
--
I
AA
P
Q
L
A
D
I
-----
G
E
F
-
E
T
G
V
A
Q
L
K
M
S
D
G
V
I
A
T
L
I
G
G
--
R
H
A
--
A
H
G
N
Q
V
E
L
E
V
M
G
S
N
G
W
V
R
I
G
E
H
P
-
D
---
L
N
-
R
-----
V
T
--
V
F
N
D
Q
---
G
V
-
V
-
R
---
P
---
S
L
--
Q
S
F
G
E
-----
R
F
D
T
----
A
F
T
D
E
V
Q
D
F
V
N
N
V
I
V
G
K-
Q
----
P
E---
V
T
---------
V
D
D
G
I
K
A
L
K
I
A
K
A
C
Q
Q
S
A
N
I
G
K
L
V
D
-------
86
Fugue
79.41
20%
-88
- C2 -
1ZH8
7
?
A:
[16-340]
----------------------------
L
R
K
I
R
L
G
I
V
G
C
G
I
A
A
-
R
-
E
L
H
L
P
A
L
K
-
N
-
L
---
S
H
LF--
E
I
T
A
V
T
S
R
T
R
S
H
A
E
E
F
A
K
M
V
G
-
N
P
---
A
V
----
F
D
--
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
-
K
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
I
G
D
P
V
F
M
N
W
Q
I
W
V
G
M
D
E
N
----
N
-
K
Y
V
H
-
T
D
-
W
---
R
K
-
K
PK
H
V
-
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
I
L
---
G
E
-
I
E
W
I
S
A
V
A
K
D
--
L
S-----
P
L
-----
L
G
G
M
D
F
L
S
S
I
F
E
F
E
N
G
T
V
G
N
Y
T
I
S
--
Y
S
L
--
K
--
G
N
E
R
F
E
I
T
G
T
K
G
K
I
S
I
S
W
----------------
D
K
--
I
V
L
N
E
---
E
E
M
K
-
V
---
P
---
Q
---------------
E
N
----
S
Y
Q
K
E
F
E
D
F
Y
Q
V
V
A
E
G
--
K
----
P
NDL-
G
S
---------
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
F
V
S
S
LL----
72
HHSearch
78.66
20%
-87
- C2 -
3EZY
2
?
A:
[2-330]
------------------------------
S
L
R
I
G
V
I
G
L
G
R
I
G
-
T
-
I
-
H
A
E
N
L
K
-
M
-
I
D--
D
A
----
I
L
Y
A
I
S
D
V
R
E
D
R
L
R
E
M
K
E
-
K
L
-
G
V
E
--
K
A
----
Y
K
--
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
K
K
A
-
D
-
V
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
A
V
E
N
G
T
I
G
K
P
H
V
-
L
R
I
T
S
R
D
-
P
A
P
----
P
--
P
L
D
-
Y
-------
I
-
R
--
V
S
-
G
G
I
F
L
D
M
T
I
H
D
F
D
M
-
A
R
Y
I
M
-
G
E
E
-
V
E
E
V
F
A
D
G
S
V
--
L
VD
E
E
I
G
K
A
-----
G
D
V
-
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
D
N
S
--
R
R
A
--
V
Y
G
Y
D
Q
R
I
E
V
F
G
S
K
G
R
I
F
A
D
N
V
R
-----
E
T
-
T
-----
V
V
--
L
T
D
E
Q
---
G
D
-
R
-
G
S
--
R
---
Y
L
Y-
F
F-
L
E
-----
R
Y
R
D
----
S
Y
L
E
E
L
K
T
F
I
K
N
V
K
S
G
E-
P
----
P
A---
V
S
---------
G
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
S
L
E
E
K
R
S
V
K
-------
66
HHSearch
76.62
18%
-86
- C2 -
3EUW
1
?
A:
[3-331]
-----------------------------
L
T
L
R
I
A
L
F
G
A
G
R
I
G
-
H
-
V
-
H
A
A
N
I
A
-
A
-
N
P--
D
L
----
E
L
V
V
I
A
D
P
F
I
E
G
A
Q
R
L
A
E
-
A
N
-
G
A
---
E
A
----
V
A
--
S
P
D
E
V
F
A
R
D
D
I
D
G
I
V
I
G
S
P
T
S
T
H
V
D
L
I
T
R
A
V
E
R
G
I
P
A
L
C
E
K
P
I
D
L
D
I
E
M
V
R
A
C
K
E
K
I
G
D
G
-
A
-
S
K
V
M
L
G
F
N
R
R
F
D
P
S
F
A
A
I
N
A
R
V
A
N
Q
E
I
G
N
L
E
Q
-
L
V
I
I
S
R
D
-
P
A
P
----
A
--
P
K
D
-
Y
I
--------
A
--
G
S
-
G
G
I
F
R
D
M
T
I
H
D
L
D
M
-
A
R
F
F
V
-
P
N
--
I
V
E
V
T
A
T
G
A
N
--
V
F
S
Q
E
I
A
E
F
-----
N
D
Y
-
D
Q
V
I
V
T
L
R
G
S
K
G
E
L
I
N
I
V
N
S
--
R
H
C
SY
G
--
Y
D
Q
R
L
E
A
F
G
S
K
G
M
L
A
A
D
N
I
--
R
---
P
T
-
T
-----
V
R
--
K
H
N
A
E
---
S
T
-
E
-
Q
A
--
D
P--
I
F
NF
F
--
L
E
-----
R
Y
D
A
----
A
Y
K
A
E
L
A
T
F
A
Q
G
I
R
D
G
Q-
G
----
F
S---
P
N
---------
F
E
D
G
V
I
A
L
E
L
A
N
A
C
L
E
S
A
Q
T
G
R
T
V
T
-------
69
HHSearch
75.72
18%
-84
* C2 *
3DB2
-
?
A:
[3-348]
----------------------------
Y
N
P
V
G
V
A
A
I
G
L
G
R
W
A
-
Y
-
V
-
M
A
D
A
Y
T
-
K
-
S
E--
K
L
----
K
L
V
T
C
Y
S
R
T
E
D
K
R
E
K
F
G
K
-
R
Y
-
N
C
---
A
G
----
D
A
--
T
M
E
A
L
L
A
R
E
D
V
E
M
V
I
I
T
V
P
N
D
K
H
A
E
V
I
E
Q
C
A
R
S
G
K
H
I
Y
V
E
K
P
I
S
V
S
L
D
H
A
Q
R
I
D
Q
V
I
K
E
T
-
G
-
V
K
F
L
C
G
H
S
S
R
R
L
G
A
L
R
K
M
K
E
M
I
D
T
K
E
I
G
E
V
S
S
-
I
E
A
V
F
S
N
-
E
R
G
LE--
L
-
K
K
G
N
-
W
R
-
G
---
E
P
A
T
--
A
P
-
G
G
P
L
T
Q
L
G
V
H
Q
I
D
N
-
L
Q
F
L
L
-
G
P
V
--
A
R
V
F
N
F
G
K
P
M
Y
T
------
E
V
-----
E
N
I
-
T
V
N
Q
T
L
L
E
F
E
D
G
K
Q
A
Y
L
G
T
N
--
W
A
C
--
P
--
G
V
F
S
I
N
V
Y
G
T
K
A
N
L
F
Y
Q
L
D
F
-
S
WWS
N
S
-
D
VTDEH
S
T
--
L
I
K
R
E
FAS-----
N
R
I
L
R
---
D
V
--
K
V
-
D
F
-----
E
S
V
D
----
H
L
R
V
E
V
E
E
V
A
D
V
I
R
N
G
G
-
E
----
T
E---
I
G
---------
A
E
A
S
L
R
N
L
A
V
V
L
A
A
V
K
S
V
H
E
K
R
P
V
E
-------
19
PsiBlast_PDB
74.81
31%
-95
- C3 -
1OFG
1
GFO_ZYMMO
A:
[32-233]
-------------------------------
F
G
Y
A
I
V
G
L
G
K
Y
A
L
N
-
Q
-
I
L
P
G
F
A
-
G
-
C
---
Q
H
S---
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
-
E
Y
-
G
V
D
PR
K
I
----
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
-
V
T
T
D
N
S
D
-
V
M
D
----
Q
N
D
P
A
Q
-
Q
W
R
L
---
R
R
-
E
--
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
-
T
R
Y
L
L
-
G
E
E
-
P
I
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
74.55
31%
-95
- C3 -
1OFG
1
GFO_ZYMMO
B:
[32-233]
-------------------------------
F
G
Y
A
I
V
G
L
G
K
Y
A
L
N
-
Q
-
I
L
P
G
F
A
-
G
-
C
---
Q
H
S---
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
-
E
Y
-
G
V
D
PR
K
I
----
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
-
V
T
T
D
N
S
D
-
V
M
D
----
Q
N
D
P
A
Q
-
Q
W
R
L
---
R
R
-
E
--
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
-
T
R
Y
L
L
-
G
E
E
-
P
I
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
74.21
31%
-95
- C3 -
1OFG
1
GFO_ZYMMO
D:
[32-233]
-------------------------------
F
G
Y
A
I
V
G
L
G
K
Y
A
L
N
-
Q
-
I
L
P
G
F
A
-
G
-
C
---
Q
H
S---
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
-
E
Y
-
G
V
D
PR
K
I
----
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
-
V
T
T
D
N
S
D
-
V
M
D
----
Q
N
D
P
A
Q
-
Q
W
R
L
---
R
R
-
E
--
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
-
T
R
Y
L
L
-
G
E
E
-
P
I
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------