@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0286: (2016-03-14 )
MKISKRLQNLPDQFFSSLVEKVGKKVAEGHDVINLGQGNPDQPTPKHIVEAMKTASEKPLNHKYSLFRGKQELKQAAADFYAREYNVTIDPNTEVAILFGTKTGLVELPMCLMDPGDTMLLPDPGYPDYLSGVVLGEVQFEKMPLIAENDFLPDFTKIPEDIAEKTELMYLNYPNNPTGAVATADFFEETVAFAKNHNIVVAHDFAYGGIGFDGKKPISFLETNGAKEVGIELYTLSKTYNMAGWRVGFAVGNSEVIEAINLIQDHMYVSLFPGIQDAAIEALTGDQACVRELTARYENRRDAFISACREIGWEAVAPAGSFFAWMPVPEDFTSSEFADYLLEEVSVAVADGSGFGEFGEGYVRVGLLMDEERLEEAVTRVSKLHLFDKVTQQ
Atome Classification :
(20 SA)
-.........10----..-......20.-....-.-.-.30.........40........50........60..-----......70........80.....-...90..----.......100.......110...--....120..---....---.130...-.--...140....-...-150.......160.---......170.......180.......190.......200.......210...-------....220.-..----....230.......240.......250-.......260.......270..--.....280.---....--.--.---290.........300.......310.-----.......320....---...330-.----.---......340.......350...------....360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
K
I
S
K
R
L
Q
NL
P
----
D
Q
-
F
F
S
S
L
V
E
K
V
-
G
K
K
V
-A-E-GH-
D
V
I
NLGQGNPDQP
T
P
K
H
I
V
E
A
M
K
T
ASEKPLN
H
K
-----
Y
S
L
F
R
G
K
Q
E
L
K
Q
A
A
A
D
F
Y
A
R
E
Y
N
-
V
T
ID-PN----T
E
V
A
I
L
FGTKT
G
L
V
EL
P
M
C
LMDP--GD
T
M
LLPDP---GY
P
D
---
Y
L
S
G
V
V
L
-G--
E
V
Q
F
EKM
P
L
I-AEN-DFLP
D
F
T
K
I
P
E
D
I
A
---EK
T
E
L
M
Y
L
NYPNNPTGA
V
A
T
A
D
F
F
E
E
T
V
A
FAKNH
N
I
V
V
A
H
DFAYGGIGFDGK-------K
P
I
S
F
LET-NG----A
K
E
V
G
I
E
L
Y
T
L
SKTYNMA
G
W
R
V
G
F
A
VG-
N
S
E
V
I
E
A
I
N
L
I
Q
D
H
M
Y
V
S
LFPG--
I
Q
D
A
A
I
E
AL---TG
D
Q
--
A
--
C
---
V
--
R
E
L
T
A
R
YEN
R
R
D
A
F
I
S
A
C
R
EI-G-----WEAVAPAG
S
F
F
A
WM---PVPE-D-F----
T
---
S
S
E
F
A
D
Y
L
L
E
E
V
S
V
A
VADGSGF------
G
E
FGE
G
Y
V
R
V
G
L
LM
D
E
E
R
L
E
E
A
V
T
R
V
S
K
L
H
L
F
D
K
V
TQQ
21
PsiBlast_CBE
92.40
39%
-93
- C1 -
2X5D
6
?
D:
[21-398]
-------------------
V
F
N
I
T
A
E
L
K
-
M
A
A
R
-
R
-
R
-
G
E
-
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
Q
R
E
D
T
H
G
-----
Y
S
T
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
D
-
V
Q
I
D
-
P
E
----
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
T
I
L
V
P
N
P
---
S
Y
P
I
---
H
I
Y
G
A
V
I
-
A
--
G
A
Q
V
R
S
V
P
L
V
-
P
G
I
-
D
F
F
N
E
L
E
R
A
I
R
E
S
I
---
P
K
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
-------
K
A
P
S
I
M
Q
V
-
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
K
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
-
N
P
E
L
V
S
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
--
L
Q
V
A
A
I
A
A
L
---
E
G
D
Q
--
Q
--
C
---
V
--
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
-
G
-----
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
---
K
I
P
E
-
P
-
Y
----
A
HLG
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
Y
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
-----
1
PsiBlast_PDB
92.09
43%
-88
- C1 -
2O1B
1
?
A:
[22-399]
---
I
S
N
K
L
A
N
I
P
----
D
S
-
Y
F
G
------------
E
-
H
-
G
P
L
P
L
I
N
M
A
V
G
I
P
D
G
P
T
P
Q
G
I
I
D
H
F
Q
K
A
L
T
I
P
E
N
Q
K
-----
Y
G
A
F
H
G
K
E
A
F
K
Q
A
I
V
D
F
Y
Q
R
Q
Y
N
-
V
T
L
D
-
K
E
----
D
E
V
C
I
L
Y
G
T
K
N
G
L
V
A
V
P
T
C
V
I
N
P
--
G
D
Y
V
L
L
P
D
P
---
G
Y
T
D
---
Y
L
A
G
V
L
L
-
A
--
D
G
K
--
P
V
P
L
N
-
L
E
P
P
H
Y
L
P
D
W
S
K
V
D
S
Q
I
I
---
D
K
T
K
L
I
Y
L
T
Y
P
N
N
P
T
G
S
T
A
T
K
E
V
F
D
E
A
I
A
K
F
K
G
T
D
T
K
I
V
H
D
F
A
Y
G
A
F
G
F
D
A
K
-------
N
P
-
S
I
L
A
S
-
E
N
----
G
K
D
V
A
I
E
I
Y
S
L
S
K
G
Y
N
M
S
G
F
R
V
G
F
A
V
G
-
N
K
D
M
I
Q
A
L
K
K
Y
Q
T
H
T
N
A
G
M
F
G
A
--
L
Q
D
A
A
I
Y
A
L
---
N
H
Y
D
--
D
--
F
---
L
--
E
E
Q
S
N
V
F
K
T
R
R
D
R
F
E
A
M
L
A
K
A
-
D
-----
L
P
F
V
H
A
K
G
G
I
Y
V
W
L
---
E
T
P
P
-
G
-
Y
----
D
---
S
E
Q
F
E
Q
F
L
V
Q
E
K
S
I
L
V
A
P
G
K
P
F
------
G
E
N
G
N
R
Y
V
R
I
S
L
A
L
D
D
Q
K
L
D
E
A
A
I
R
L
T
E
L
---------
2
PsiBlast_PDB
91.61
39%
-96
- C1 -
2X5D
3
?
A:
[21-398]
-------------------
V
F
N
I
T
A
E
L
K
-
M
A
A
R
-
R
-
R
-
G
E
-
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
--------------
T
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
D
-
V
Q
I
D
-
P
E
----
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
T
I
L
V
P
N
P
---
S
Y
P
I
---
H
I
Y
G
A
V
I
-
A
--
G
A
Q
V
R
S
V
P
L
V
-
P
G
I
-
D
F
F
N
E
L
E
R
A
I
R
E
S
I
---
P
K
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
-------
K
A
P
S
I
M
Q
V
-
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
-
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
-
N
P
E
L
V
S
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
--
L
Q
V
A
A
I
A
A
L
---
E
G
D
Q
--
Q
--
C
---
V
--
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
-
G
-----
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
---
K
I
P
E
-
P
-
Y
----
A
HLG
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
Y
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
-----
22
PsiBlast_CBE
90.63
39%
-96
- C1 -
2X5D
4
?
C:
[22-398]
--------------------
F
N
I
T
A
E
L
K
-
M
A
A
R
-
R
-
R
-
G
E
-
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
Q
R
-------------
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
D
-
V
Q
I
D
-
P
E
----
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
T
I
L
V
P
N
P
---
S
Y
P
I
---
H
I
Y
G
A
V
I
-
A
--
G
A
Q
V
R
S
V
P
L
V
-
P
G
I
-
D
F
F
N
E
L
E
R
A
I
R
E
S
I
---
P
K
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
-------
K
A
P
S
I
M
Q
V
-
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
K
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
-
N
P
E
L
V
S
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
--
L
Q
V
A
A
I
A
A
L
---
E
G
D
Q
--
Q
--
C
---
V
--
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
-
G
-----
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
---
K
I
P
E
-
P
-
Y
----
A
HLG
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
Y
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
-----
23
PsiBlast_CBE
90.44
39%
-94
- C1 -
2X5D
2
?
B:
[21-398]
-------------------
V
F
N
I
T
A
E
L
K
-
M
A
A
R
-
R
-
R
-
G
E
-
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
Q
--------------
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
D
-
V
Q
I
D
-
P
E
----
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
T
I
L
V
P
N
P
---
S
Y
P
I
---
H
I
Y
G
A
V
I
-
A
--
G
A
Q
V
R
S
V
P
L
V
-
P
G
I
-
D
F
F
N
E
L
E
R
A
I
R
E
S
I
---
P
K
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
-------
K
A
P
S
I
M
Q
V
-
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
K
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
-
N
P
E
L
V
S
A
L
A
R
I
K
S
Y
H
D
Y
----
P
--
L
Q
V
A
A
I
A
A
L
---
E
G
D
Q
--
Q
--
C
---
V
--
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
-
G
-----
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
---
K
I
P
E
-
P
-
Y
----
A
HLG
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
Y
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
-----
33
HHSearch
88.40
39%
-95
- C1 -
2X5D
3
?
A:
[21-400]
-------------------
V
F
N
-
I
T
A
E
L
-
K
M
A
A
-
R
R
R
-
G
E
-
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
--------------
T
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
D
-
V
Q
I
D
-
P
E
----
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
T
I
L
V
P
N
P
---
S
Y
P
I
---
H
I
Y
G
A
V
I
-
A
--
G
A
Q
V
R
S
V
P
L
V
-
P
G
I
----
D
F
F
N
E
L
E
R
A
I
R
E
SI
P
K
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
-------
K
A
P
S
I
M
Q
V
-
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
-
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
-
N
P
E
L
V
S
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
--
L
Q
V
A
A
I
A
A
L
---
E
G
D
Q
--
Q
--
C
---
V
--
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
-
G
-----
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
---
K
I
P
E
-
P
-
Y
AHL-
G
---
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
Y
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
G
L
---
25
PsiBlast_CBE
85.16
32%
-90
- C1 -
1GD9
2
?
B:
[2-382]
--
A
L
S
D
R
L
E
L
V
S
---------
A
S
E
I
R
K
L
-
F
D
I
A
-
A
-
G
-
M
K
-
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
------
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
-
P
K
----
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
--
G
E
E
V
L
I
P
T
P
---
A
F
V
S
---
Y
A
P
A
V
I
L
-
A
--
G
G
K
P
V
E
V
P
T
Y
-
E
E
D
-
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
-------
R
H
Y
S
I
A
S
L
-
D
G
----
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
--
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
TF
I
Q
Y
A
A
A
K
A
L
---
K
D
E
R
--
S
WK
A
---
V
--
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
---
R
I
R
D
-
T
G
L
----
T
---
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
------
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
---------
24
PsiBlast_CBE
83.25
32%
-89
- C1 -
1GDE
4
?
B:
[2-382]
--
A
L
S
D
R
L
E
L
V
S
---------
A
S
E
I
R
K
L
-
F
D
I
A
-
A
-
G
-
M
K
-
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
------
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
-
P
K
----
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
--
G
E
E
V
L
I
P
T
P
---
A
F
V
S
---
Y
A
P
A
V
I
L
-
A
--
G
G
K
P
V
E
V
P
T
Y
-
E
E
D
-
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
-------
R
H
Y
S
I
A
S
L
-
D
G
----
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
--
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
TF
I
Q
Y
A
A
A
K
A
L
---
K
D
E
R
--
S
WK
A
---
V
--
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
---
R
I
R
D
-
T
G
L
----
T
---
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
------
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
---------
3
PsiBlast_PDB
82.99
32%
-90
- C1 -
1GDE
4
?
A:
[2-382]
--
A
L
S
D
R
L
E
L
V
S
---------
A
S
E
I
R
K
L
-
F
D
I
A
-
A
-
G
-
M
K
-
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
------
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
-
P
K
----
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
--
G
E
E
V
L
I
P
T
P
---
A
F
V
S
---
Y
A
P
A
V
I
L
-
A
--
G
G
K
P
V
E
V
P
T
Y
-
E
E
D
-
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
-------
R
H
Y
S
I
A
S
L
-
D
G
----
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
--
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
E
R
--
S
W
K
A
---
V
--
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
---
R
I
R
D
-
T
G
L
----
T
---
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
------
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
---------
4
PsiBlast_PDB
82.02
32%
-90
- C1 -
1GD9
2
?
A:
[2-382]
--
A
L
S
D
R
L
E
L
V
S
---------
A
S
E
I
R
K
L
-
F
D
I
A
-
A
-
G
-
M
K
-
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
------
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
-
P
K
----
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
--
G
E
E
V
L
I
P
T
P
---
A
F
V
S
---
Y
A
P
A
V
I
L
-
A
--
G
G
K
P
V
E
V
P
T
Y
-
E
E
D
-
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
-------
R
H
Y
S
I
A
S
L
-
D
G
----
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
--
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
E
R
--
S
W
K
A
---
V
--
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
---
R
I
R
D
-
T
G
L
----
T
---
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
------
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
---------
28
HHSearch
81.97
31%
-89
- C1 -
1GD9
2
?
A:
[2-387]
--
A
L
S
D
R
L
E
L
V
S
----
A
S
E
I
R
K
-----
L
-
F
D
I
A
-
A
-
G
-
M
K
-
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
G
L
T
H
-----
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
P
K
T
-----
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
--
G
E
E
V
L
I
P
T
P
---
A
F
V
S
---
Y
A
P
A
V
I
L
-
A
--
G
G
K
P
V
E
V
P
T
Y
-
E
E
D
-
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
-------
R
H
Y
S
I
A
S
L
-
D
G
----
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
--
I
Q
Y
A
A
A
K
A
L
---
K
D
E
R
S
W
K
--
A
---
V
--
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
---
R
I
R
D
T
G
-
L
----
T
---
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
------
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
----
26
PsiBlast_CBE
78.93
32%
-90
- C1 -
2DOU
4
?
B:
[8-373]
-------------------
S
V
F
L
V
V
D
E
A
-
K
R
K
A
-
R
-
E
R
G
V
-
G
L
I
D
L
S
I
G
S
T
D
L
P
P
P
E
A
P
L
K
A
L
A
E
A
L
N
D
P
T
T
Y
G
-----
Y
C
L
K
S
C
T
L
P
F
L
E
E
A
A
R
W
Y
E
G
R
Y
G
-
V
G
L
D
-
P
R
----
R
E
A
L
A
L
I
G
S
Q
E
G
L
A
H
L
L
L
A
L
T
E
P
--
E
D
L
L
L
L
P
E
V
---
A
Y
P
S
---
Y
F
G
A
A
R
V
-
A
--
S
L
R
T
F
L
I
P
L
---
R
E
-
D
G
L
A
D
L
K
A
V
P
E
G
V
W
---
R
E
A
K
V
L
L
L
N
Y
P
N
N
P
T
G
A
V
A
D
W
G
Y
F
E
E
A
L
G
L
A
R
K
H
G
L
W
L
I
H
D
N
P
Y
V
D
Q
V
Y
E
G
E
-------
A
P
-
S
P
L
A
L
-
P
G
----
A
K
E
R
V
V
E
L
F
S
L
S
K
S
Y
N
L
A
G
F
R
L
G
F
A
L
G
-
S
E
E
A
L
A
R
L
E
R
V
K
G
V
I
D
F
N
Q
Y
A
G
--
V
L
R
M
G
V
E
A
L
---
K
T
P
K
--
E
--
V
---
V
--
R
G
Y
A
R
V
Y
R
E
R
A
L
G
M
A
E
A
L
K
G
V
-------
L
S
L
L
P
P
R
A
T
M
Y
L
W
G
---
R
L
P
E
-
G
-
V
----
D
---
D
L
E
F
G
L
R
L
V
E
R
-
G
V
A
L
A
P
G
R
G
F
------
G
P
G
G
K
G
F
V
R
I
A
L
V
R
P
L
E
E
L
L
E
A
A
K
R
I
R
E
----------
5
PsiBlast_PDB
78.41
32%
-88
- C1 -
2DOU
4
?
A:
[4-373]
----------
V
P
----
E
P
-
S
V
F
L
V
V
D
E
A
-
K
R
K
A
-
R
-
E
R
G
V
-
G
L
I
D
L
S
I
G
S
T
D
L
P
P
P
E
A
P
L
K
A
L
A
E
A
L
N
D
P
T
T
Y
G
-----
Y
C
L
K
S
C
T
L
P
F
L
E
E
A
A
R
W
Y
E
G
R
Y
G
-
V
G
L
D
-
P
R
----
R
E
A
L
A
L
I
G
S
Q
E
G
L
A
H
L
L
L
A
L
T
E
P
--
E
D
L
L
L
L
P
E
V
---
A
Y
P
S
---
Y
F
G
A
A
R
V
-
A
--
S
L
R
T
F
L
I
P
L
---
R
E
-
D
G
L
A
D
L
K
A
V
P
E
G
V
W
---
R
E
A
K
V
L
L
L
N
Y
P
N
N
P
T
G
A
V
A
D
W
G
Y
F
E
E
A
L
G
L
A
R
K
H
G
L
W
L
I
H
D
N
P
Y
V
D
Q
V
Y
E
G
E
-------
A
P
-
S
P
L
A
L
-
P
G
----
A
K
E
R
V
V
E
L
F
S
L
S
K
S
Y
N
L
A
G
F
R
L
G
F
A
L
G
-
S
E
E
A
L
A
R
L
E
R
V
K
G
V
I
D
F
N
Q
Y
A
G
--
V
L
R
M
G
V
E
A
L
---
K
T
P
K
--
E
--
V
---
V
--
R
G
Y
A
R
V
Y
R
E
R
A
L
G
M
A
E
A
L
K
G
V
-------
L
S
L
L
P
P
R
A
T
M
Y
L
W
G
---
R
L
P
E
-
G
-
V
----
D
---
D
L
E
F
G
L
R
L
V
E
R
-
G
V
A
L
A
P
G
R
G
F
------
G
P
G
G
K
G
F
V
R
I
A
L
V
R
P
L
E
E
L
L
E
A
A
K
R
I
R
E
----------
36
HHSearch
78.13
29%
-86
* C1 *
1O4S
8
AAT_THEMA
A:
[14-388]
---
V
S
R
R
I
S
E
I
P
----
I
S
K
T
M
E
-
L
D
A
K
A
-
K
A
L
I
-
K
-
K
-
G
E
-
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
-
K
G
E
V
K
-----
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
-
K
D
I
S
-
P
D
-----
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
--
G
D
E
V
I
V
F
S
P
---
V
W
V
S
---
Y
I
P
Q
I
I
L
-
A
--
G
G
T
V
N
V
V
E
T
F
-
M
S
K
-
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
---
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
--------
F
T
S
I
L
D
V
-
S
E
----
G
F
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
-
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
--
A
Q
Y
A
A
L
K
A
L
---
E
V
D
----------
N
--
S
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
-----
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
---
K
V
R
G
--------
D
---
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
------
L
K
--
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
------
52
Fugue
76.99
30%
-91
- C1 -
1BJW
1
AAT_THET8
A:
[1-382]
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
-
V
N
A
K
A
L
E
L
R
-
R
Q
-------
G
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
------
Q
GKTK
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
------SVTP
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
--
G
D
E
V
I
V
L
S
P
---
Y
W
V
S
---
Y
P
E
M
V
R
F
A
G
--
G
V
-
V
V
E
V
E
T
-
L
P
E
E
-
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
PGR----------
V
----
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
-
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
--
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
R
--
A
--
F
---
V
--
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
--
G
L
K
A
V----
R
P
S
G
A
F
Y
V
L
M
---
D
T
S
-----PIAP
D
---
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
------
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--------
39
HHSearch
76.88
32%
-94
- C1 -
2DOU
4
?
A:
[16-375]
---------------------------
A
-
K
R
K
A
-
R
E
R
-
G
V
-
G
L
I
D
L
S
I
G
S
T
D
L
P
P
P
E
A
P
L
K
A
L
A
E
A
L
N
D
P
T
T
Y
G
-----
Y
C
L
K
S
C
T
L
P
F
L
E
E
A
A
R
W
Y
E
G
R
Y
G
-
V
G
L
D
-
P
R
----
R
E
A
L
A
L
I
G
S
Q
E
G
L
A
H
L
L
L
A
L
T
E
P
--
E
D
L
L
L
L
P
E
V
---
A
Y
P
S
---
Y
F
G
A
A
R
V
-
A
--
S
L
R
T
F
L
I
P
L
R
-
E
D
---
G
L
A
D
L
K
A
V
P
E
G
V
W
---
R
E
A
K
V
L
L
L
N
Y
P
N
N
P
T
G
A
V
A
D
W
G
Y
F
E
E
A
L
G
L
A
R
K
H
G
L
W
L
I
H
D
N
P
Y
V
D
Q
V
Y
E
G
E
-------
A
P
S
P
L
A
-
L
-
P
G
----
A
K
E
R
V
V
E
L
F
S
L
S
K
S
Y
N
L
A
G
F
R
L
G
F
A
L
G
-
S
E
E
A
L
A
R
L
E
R
V
K
G
V
I
D
F
N
Q
Y
A
G
--
V
L
R
M
G
V
E
A
L
---
K
T
P
K
--
E
--
V
---
V
--
R
G
Y
A
R
V
Y
R
E
R
A
L
G
M
A
E
A
L
K
G
V
-------
L
S
L
L
P
P
R
A
T
M
Y
L
W
G
---
R
L
P
E
-
G
-
V
----
D
---
D
L
E
F
G
L
R
L
-
V
E
R
G
V
A
L
A
P
G
R
G
F
------
G
P
G
G
K
G
F
V
R
I
A
L
V
R
P
L
E
E
L
L
E
A
A
K
R
I
R
E
A
L
--------
6
PsiBlast_PDB
76.85
29%
-85
- C1 -
1O4S
8
AAT_THEMA
A:
[14-382]
---
V
S
R
R
I
S
E
I
P
----
I
S
-
K
T
M
E
L
D
A
K
A
-
K
A
L
I
-
K
-
K
-
G
E
-
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
-
E
V
K
-----
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
-
K
D
I
S
-
P
D
-----
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
--
G
D
E
V
I
V
F
S
P
---
V
W
V
S
---
Y
I
P
Q
I
I
L
-
A
--
G
G
T
V
N
V
V
E
T
F
-
M
S
K
-
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
---
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
-------
F
-
T
S
I
L
D
V
-
S
E
----
G
F
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
-
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
--
A
Q
Y
A
A
L
K
A
L
---
E
V
D
N
--
S
--
Y
--------
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
-----
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
---
K
V
R
G
-
D
----------
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
--------
L
K
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
------------
27
HHSearch
76.12
29%
-80
- C1 -
1J32
2
?
A:
[1-386]
-
M
K
L
A
A
R
V
E
S
V
S
----
P
S
-
M
T
L
I
I
D
A
-
K
-
A
K
A
M
K
A
-
E
-
G
I
-
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
-
Q
G
K
T
R
-----
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
-
L
C
Y
G
-
A
D
-----
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
--
G
D
E
V
I
I
P
A
P
---
F
W
V
S
---
Y
P
E
M
V
K
L
-
A
--
E
G
T
P
V
I
L
P
T
T
-
V
E
T
-
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
---
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
-------
Q
H
L
S
I
G
A
A
S
P
E
----
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
-
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
--
A
Q
Y
G
A
I
A
A
Y
---
E
N
S
Q
--
D
--
C
---
V
--
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
-----
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
---
S
I
A
K
T
G
-
R
----
S
---
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
------
G
A
--
D
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
------
8
PsiBlast_PDB
75.04
30%
-84
- C1 -
1B5O
3
AAT_THET8
A:
[4-381]
---
L
S
R
R
V
Q
A
M
K
----
P
S
-
A
T
V
A
V
N
A
K
A
-
L
E
L
R
-
R
-
Q
-
G
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
-----
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
-
P
E
-----
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
--
G
D
E
V
I
V
L
S
P
YWV
S
Y
P
E
M
V
R
F
A
G
G
V
V
------
V
E
V
E
T
L
P
----
E
E
-
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-------
H
---
F
S
P
G
-
R
V
----
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
--
A
Q
W
A
T
L
E
A
L
---
T
N
Q
E
--
A
--
S
R
A
F
V
--
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TS
P
I
A
P
-
D
-
E
----
V
---
R
A
--
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
------
A
A
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
---------
18
PsiBlast_PDB
74.63
28%
-81
- C1 -
3JTX
5
?
A:
[6-395]
-------
L
K
Q
L
K
----
P
Y
-
P
F
A
R
L
H
E
A
M
Q
G
I
S
A
-
P
-
E
-
G
M
-
E
A
V
P
L
H
I
G
E
P
K
H
P
T
P
K
V
I
T
D
A
L
-
T
A
S
L
H
E
L
-
E
K
-----
Y
P
L
T
A
G
L
P
E
L
R
Q
A
C
A
N
W
L
K
R
R
Y
D
G
L
T
V
D
-
A
D
----
N
E
I
L
P
V
L
G
S
R
E
A
L
F
S
F
V
Q
T
V
L
N
P
G
I
K
P
A
I
V
S
P
N
P
---
F
Y
Q
I
---
Y
E
G
A
T
L
L
-
G
G
G
E
I
H
F
A
N
C
P
----
A
P
-
S
F
N
P
D
W
R
S
I
S
E
E
V
W
---
K
R
T
K
L
V
F
V
C
S
P
N
N
P
S
G
S
V
L
D
L
D
G
W
K
E
V
F
D
L
Q
D
K
Y
G
F
I
I
A
S
D
E
C
Y
S
E
I
Y
F
D
G
N
-------
K
P
L
G
C
L
Q
A
-
A
A
Q
L
GR
S
R
Q
K
L
L
M
F
T
S
L
S
K
R
S
N
V
P
G
L
R
S
G
F
V
A
G
-
D
A
E
L
L
K
N
F
L
L
Y
R
T
Y
H
G
S
A
M
S
I
P
--
V
Q
R
A
S
I
A
A
W
---
D
D
E
Q
--
H
--
V
---
I
D
N
R
R
L
---
Y
Q
E
K
F
E
R
V
I
P
I
L
Q
Q
V
-------
F
D
V
K
L
P
D
A
S
F
Y
I
W
L
---
K
V
P
--
D
-
G
----
D
---
D
L
A
F
A
R
N
L
W
Q
K
A
A
I
Q
V
L
P
G
R
F
L
ARDTEQ
G
N
P
G
E
G
Y
V
R
I
A
L
V
A
D
V
A
T
C
V
K
A
A
E
D
I
V
S
L
Y
--------