@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0305: (2016-03-14 )
MTNTLKTSYQKTPYKLGGNGPRNVGVLTEALQNIDDNLESDIYGNGAVIEDFETKIAKILGKQSAVFFPSGTMAQQIALRIWADRKENRRVAYHPLSHLEIHEQDGLKELQQITPLLLGTANQLLTIDDIKSLREPVSSVLIELPQREIGGQLPAFEELEKISEYCHEQGISLHLDGARLWEITPFYQKSAEEICALFDSVYVSFYKGIGGIAGAILAGNDDFVQEAKIWKRRYGGDLISLYPYILSADYYFEKRIGKMAEYFEAAKGLAERFNSCSGVKTVPEVPVSNMFHVYFENSADEIGAILTKIQDETGVGISGYLQEKSADVCAFEVSVGDAFAEIPAKNLELVFRCLEKEL
Atome Classification :
(20 SA)
.........10........20........30........40--.........50........60---.--------.----.--.-.--...-.70........80...-...------..--90........100..-.....110.......-.120----.-----------.----......130-.-------.--------.---------.-------...140.......150.......160.......170.........180..-...--------..--190..----..---...--.200.....--.---.210.---.......220-........230....------.-..-240..----------.-...-.250..---.---.-.-.-..-260.......270...-....280.....---...--290.......-------300.......310.......320.-----.-----------.....330.....-..340.......350......----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTNTLKTSYQKT
P
Y
KLGGNGPR
N
V
G
V
L
T
E
A
L
Q
N
I
D
D
N
L
E
S---DIYGNG
A
V
I
E
D
F
E
T
K
I
A
K
I
L----G--------K----Q--S-
A
--
V
FF-PS
G
T
M
A
Q
Q
I
A
L
R
IWAD-RKE------N
R
--
R
V
A
YHPLS
H
L
E
IH
E
Q
-
D
G
L
K
E
L
Q
-
Q
I
T
P
L
L
L-GT-A----N-----------
Q
----
L
L
T
I
D
D
I
K
S
-
L
-------
R
--------
E
---------
P
-------
V
S
S
V
L
I
EL
P
Q
R
EIGGQLP
A
F
E
E
L
E
K
I
S
E
Y
C
H
EQG--
I
S
L
H
LDG
A
R
L
W
E
IT-
P
F
Y
--------
Q
K
--
S
-
A
E
E
----
I
C
---
A
L
F
--
D
S
V
Y
V
S
F
Y
K
--
G
---
I
G
-
G
I
---
A
G
A
I
LAGN
D
--
D
F
V
Q
E
A
K
I
W
K
R
R
YGG------
D
-
L
I
-
S
L
Y
P
Y
----------
I
-LS
A
-
D
Y
-
Y
F
E
---
K
---
R
-
I
-
G
-
K
M
-
A
E
Y
F
E
A
A
K
G
L
A
E
R
F
N
S-CSGVKT-VPEVP---VS
N
--
M
F
H
V
Y
FENS
A
-------
D
E
I
G
A
I
L
T
K
IQDETGVGI
S
G
Y
L
QE-----K-----------SA
D
V
C
A
F
E
VSVG
D
-
A
F
A
EIPAK
N
L
E
L
V
F
R
C
L
E
KEL----------------------------
1
PsiBlast_PDB
99.79
98%
-119
- C1 -
3PJ0
4
?
A:
[3-359]
-
T
N
T
L
K
T
S
Y
Q
K
T
P
Y
K
L
G
G
N
G
P
R
N
V
G
V
L
T
E
A
L
Q
N
I
D
D
N
L
E
S
---
D
I
Y
G
N
G
A
V
I
E
D
F
E
T
K
I
A
K
I
L
----
G
--------
K
----
Q
--
S
-
A
--
V
F
F
-
P
S
G
T
M
A
Q
Q
I
A
L
R
I
W
A
D
-
R
K
E
------
N
R
--
R
V
A
Y
H
P
L
S
H
L
E
I
H
E
Q
-
D
G
L
K
E
L
Q
-
Q
I
T
P
L
L
L
-
G
T
-
A
----
N
-----------
Q
----
L
L
T
I
D
D
I
K
S
-
L
-------
R
--------
E
---------
P
-------
V
S
S
V
L
I
E
L
P
Q
R
E
I
G
G
Q
L
P
A
F
E
E
L
E
K
I
S
E
Y
C
H
E
Q
G
--
I
S
L
H
L
D
G
A
R
L
W
E
I
T
-
P
F
Y
--------
Q
K
--
S
-
A
E
E
----
I
C
---
A
L
F
--
D
S
V
Y
V
S
F
Y
K
--
G
---
I
G
-
G
I
---
A
G
A
I
L
A
G
N
D
--
D
F
V
Q
E
A
K
I
W
K
R
R
Y
G
G
------
D
-
L
I
-
S
L
Y
P
Y
----------
I
-
L
S
A
-
D
Y
-
Y
F
E
---
K
---
R
-
I
-
G
-
K
M
-
A
E
Y
F
E
A
A
K
G
L
A
E
R
F
N
S
-
C
S
G
V
K
T
-
V
P
E
V
P
---
V
S
N
--
M
F
H
V
Y
F
E
N
S
A
-------
D
E
I
G
A
I
L
T
K
I
Q
D
E
T
G
V
G
I
S
G
Y
L
Q
E
-----
K
-----------
S
A
D
V
C
A
F
E
V
S
V
G
D
-
A
F
A
E
I
P
A
K
N
L
E
L
V
F
R
C
L
E
K
E
L
----------------------------
21
HHSearch
97.95
97%
-117
- C1 -
3PJ0
4
?
A:
[2-358]
M
T
N
T
L
K
T
S
Y
Q
K
T
P
Y
K
L
G
G
N
G
P
R
N
V
G
V
L
T
E
A
L
Q
N
I
D
D
N
L
E
S
---
D
I
Y
G
N
G
A
V
I
E
D
F
E
T
K
I
A
K
I
L
----
G
--------
K
----
Q
--
S
-
A
--
V
F
F
-
P
S
G
T
M
A
Q
Q
I
A
L
R
I
W
A
D
R
K
E
N
-------
R
--
R
V
A
Y
H
P
L
S
H
L
E
I
H
E
Q
-
D
G
L
K
E
L
Q
-
Q
I
T
P
L
L
L
-
G
T
-
A
----
N
-----------
Q
----
L
L
T
I
D
D
I
K
S
-
L
-------
R
--------
E
---------
P
-------
V
S
S
V
L
I
E
L
P
Q
R
E
I
G
G
Q
L
P
A
F
E
E
L
E
K
I
S
E
Y
C
H
E
Q
G
--
I
S
L
H
L
D
G
A
R
L
W
E
I
T
-
P
F
Y
--------
Q
K
--
S
-
A
E
E
----
I
C
---
A
L
F
--
D
S
V
Y
V
S
F
Y
K
--
G
---
I
G
-
G
I
---
A
G
A
I
L
A
G
N
D
--
D
F
V
Q
E
A
K
I
W
K
R
R
Y
G
G
------
D
-
L
I
-
S
L
Y
P
-----------
Y
-
I
L
S
-
A
D
Y
Y
F
E
---
K
---
R
-
I
-
G
-
K
M
-
A
E
Y
F
E
A
A
K
G
L
A
E
R
F
N
S
-
C
S
G
V
K
T
-
V
P
E
V
P
---
V
S
N
--
M
F
H
V
Y
F
E
N
S
A
-------
D
E
I
G
A
I
L
T
K
I
Q
D
E
T
G
V
G
I
S
G
Y
L
Q
E
-----
K
-----------
S
A
D
V
C
A
F
E
V
S
V
G
D
-
A
F
A
E
I
P
A
K
N
L
E
L
V
F
R
C
L
E
K
E
-----------------------------
23
HHSearch
68.03
22%
-98
- C1 -
1JG8
3
?
A:
[16-341]
----------------------
P
T
E
E
M
R
K
A
M
A
Q
A
--
E
V
G
D
---
D
V
Y
G
E
D
P
T
I
N
E
L
E
R
L
A
A
E
T
F
----
G
--------
K
----
E
--
A
-
A
--
L
F
V
-
P
S
G
T
M
G
N
Q
V
S
I
M
A
H
T
Q
--
R
G
-------
D
--
E
V
I
L
E
A
D
S
H
I
F
W
Y
E
V
-
G
A
M
A
V
L
S
-
G
V
M
P
H
P
V
-
P
G
-
K
----
N
-----------
G
----
A
M
D
P
D
D
V
R
K
-
A
I------
R
PRNIHF--
P
---------
R
-------
T
S
L
I
A
I
E
N
T
H
N
R
S
G
G
R
V
V
P
L
E
N
I
K
E
I
C
T
I
A
K
E
H
G
--
I
N
V
H
I
D
G
A
R
I
F
N
A
S
-
I
A
S
--------
G
V
--
P
-
V
K
E
----
Y
A
---
G
Y
A
--
D
S
V
M
F
C
L
S
K
--
G
---
L
C
-
A
P
---
V
G
S
V
V
V
G
D
R
--
D
F
I
E
R
A
R
K
A
R
K
M
L
G
G
------
G
-
M
R
-
Q
A
G
V
L
----------
A
-
A
A
G
-
I
I
-
A
L
T
---
K
---
M
-
V
-
D
-
R
L
-
K
E
D
H
E
N
A
R
F
L
A
L
K
L
K
E
-
I
-
G
Y
S
V
-
N
P
E
D
V
---
K
T
N
--
M
V
I
L
R
T
D
N
L
K
-------
V
N
A
H
G
F
I
-
E
A
L
R
N
S
G
V
L
A
N
A
V
S
----------------------
D
T
E
I
R
L
V
T
H
K
-
D
V
S
R
N
D
I
E
E
A
L
N
I
F
E
K
---------------------------------
24
HHSearch
66.10
21%
-100
- C1 -
3WGC
2
LTAA_AERJA
A:
[16-338]
---------------------
Q
P
T
D
A
M
R
Q
C
M
L
H
A
--
E
V
G
D
---
D
V
Y
G
E
D
P
G
V
N
A
L
E
A
Y
G
A
D
L
L
----
G
--------
K
----
E
--
A
-
A
--
L
F
V
-
P
S
G
T
M
S
N
L
L
A
V
M
S
H
C
Q
--
R
G
-------
E
--
G
A
V
L
G
S
A
A
H
I
Y
R
Y
E
A
-
Q
G
S
A
V
L
G
-
S
V
A
L
Q
P
V
-
P
M
-
Q
A---
D
-----------
G
----
S
L
A
L
A
D
V
R
A
-
A
I------
A
--------
P
DDVYFT---
P
-------
T
R
L
V
C
L
--
E
N
T
-
H
N
G
K
V
L
P
L
P
Y
L
R
E
M
R
E
L
V
D
E
H
G
--
L
Q
L
H
L
D
G
A
R
L
F
N
A
V
-
V
A
S
--------
G
H
--
T
-
V
R
E
----
L
V
---
A
P
F
--
D
S
V
S
I
C
L
S
K
--
G
---
L
G
-
A
P
---
V
G
S
L
L
V
G
S
H
--
A
F
I
A
R
A
R
R
L
R
K
M
V
G
G
------
G
-
M
R
-
Q
A
G
I
L
----------
A
-
Q
A
G
-
L
F
-
A
L
Q
---
Q
---
H
-
V
-
V
-
R
L
-
A
D
D
H
R
R
A
R
Q
L
A
E
G
L
A
A
-
L
-------
L
A
Q
V
---
Q
T
N
--
M
V
F
L
Q
---------------
A
P
L
-
L
A
F
M
K
A
R
G
I
L
F
S
--------------------------
G
E
L
R
L
V
T
H
L
-
Q
I
H
D
D
D
I
E
E
V
I
D
A
F
T
E
Y
--------------------------------
28
HHSearch
64.56
20%
-93
- C1 -
1SVV
1
?
A:
[24-354]
--------------------
V
G
M
H
P
K
I
L
D
L
M
A
R
D
-
N
M
T
Q
H
---
A
G
Y
G
Q
D
S
H
C
A
K
A
A
R
L
I
G
E
L
L
----
E
--------
R
----
P
D
A
D
-
V
--
H
F
I
-
S
G
G
T
Q
T
N
L
I
A
C
S
L
A
L
R
--
P
W
-------
E
--
A
V
I
A
T
Q
L
G
H
I
S
T
H
E
T
-
G
-
A
I
E
A
T
-
G
H
K
V
V
T
A
-
P
C
-
P
----
D
-----------
G
----
K
L
R
V
A
D
I
E
S
-
A
L
------
H
--------
E
N
RSEH
M
V
--
I
-------
P
K
L
V
Y
I
S
N
-
T
T
-
E
V
G
T
Q
Y
T
K
Q
E
L
E
D
I
S
A
S
C
K
E
H
G
--
L
Y
L
F
L
D
G
A
R
L
A
S
A
L
-
S
S
P
--------
V
N
DL
T
-
L
A
D
----
I
A
---
R
L
T
--
D
M
F
Y
I
G
A
T
K
--
A
---
G
G
-
M
F
---
G
E
A
L
I
I
L
N
D
--
A
L
K
P
N
A
R
H
L
I
K
Q
R
G
A
------
L
-
M
A
-
K
G
W
L
L
----------
G
-
I
Q
F
-
E
V
-
L
M
K
D--
N
---
L
-
F
-
F
-
E
L
G
A
H
S
N
K
M
A
A
I
L
K
A
G
L
E
A
-
C
-
G
I
R
L
-
A
-
W
P
S
---
A
S
N
--
Q
L
F
P
I
L
E
N
T
---------
M
----
I
A
E
L
N
N
D
F
D
M
Y
T
V
E
P
L
-------------------
K
D
G
T
C
I
M
R
L
C
T
S
W
-
A
T
E
E
K
E
C
H
R
F
V
E
V
L
K
R
L
--------------------------------
25
HHSearch
61.94
18%
-89
- C1 -
1V72
2
?
A:
[19-350]
---------------------
G
A
S
P
E
V
A
Q
A
L
V
K
H
-
S
S
G
Q
A
---
G
P
Y
G
T
D
E
L
T
A
Q
V
K
R
K
F
C
E
I
F
----
E
--------
R
----
D
--
V
E
V
--
F
L
V
-
P
T
G
T
A
A
N
A
L
C
L
S
A
M
T
P
--
P
W
-------
G
--
N
I
Y
C
H
P
A
S
H
I
N
N
D
E
C
-
G
A
P
E
F
F
S
N
G
A
K
L
M
T
V
-
D
G
-
P
----
A
-----------
A
----
K
L
D
I
V
R
L
R
E
-
R
T
------
R
EKVGDVH
T
T
---------
Q
-------
P
A
C
V
S
I
T
Q
A
-
T
-
E
V
G
S
I
Y
T
L
D
E
I
E
A
I
G
D
V
C
K
S
S
S
--
L
G
L
H
M
D
G
S
R
F
A
N
A
L
-
V
S
L
--------
G
C
--
S
-
P
A
E
----
M
T
WK-
A
G
V
--
D
A
L
S
F
G
A
T
K
--
N
---
G
V
-
L
A
---
A
E
A
I
V
L
F
N
T
--
S
L
A
T
E
M
S
Y
R
R
K
R
A
G
H
------
L
-
S
S
-
K
M
R
F
L
----------
S
-
A
Q
I
-
D
A
-
Y
L
T
---
D
---
D
L
W
L
R
-
N
A
-
R
K
A
N
A
A
A
Q
R
L
A
Q
G
L
E
G
-
L
G
G
V
E
V
-
L
-
G
G
T
---
E
A
N
--
I
L
F
C
R
L
D
S
----------
A
M
I
----
D
A
L
L
K
A
G
F
G
F
Y
H
D
R
W
--------------------
G
P
N
V
V
R
F
V
T
S
F
-
A
T
T
A
E
D
V
D
H
L
L
N
Q
V
R
L
A
A
-------------------------------
47
Fugue
60.32
17%
-75
- C1 -
1V72
2
?
A:
[6-350]
---------
R
P
P
A
L
G
F
S
S
D
N
I
A
G
A
S
P
E
V
A
Q
A
L
V
K
H
S
S
G
Q
A
---
G
P
Y
G
T
D
E
L
T
A
Q
V
K
R
K
F
C
E
I
F
----
E
--------
R
----
D
--
V
-
E
--
V
F
L
V
P
T
G
T
A
A
N
A
L
C
L
S
A
M
T
P
-
P
--------
W
G
--
N
I
Y
C
H
P
A
S
H
I
N
N
D
E
C
-
G
A
P
E
F
F
S
-
N
G
A
K
L
M
T
-
V
D
G
P
----
A
-----------
A
----
K
L
D
I
V
R
L
R
E
-
R
T
R
EKVGD
V
--------
H
---------
T
-------
T
Q
P
A
C
V
S
I
T
Q
A
T
E
V
G
S
I
Y
T
L
D
E
I
E
A
I
G
D
V
C
K
S
S
S
--
L
G
L
H
M
D
G
S
R
F
A
N
A
L
-
V
S
L
--------
G
C
--
S
-
P
A
E
----
M
T
---
W
K
A
GV
D
A
L
S
F
G
A
T
K
--
N
---
G
V
-
L
A
---
A
E
A
I
V
L
F
N
T
--
S
L
A
T
E
M
S
Y
R
R
K
R
A
G
H
------
L
-
S
S
-
K
M
R
F
L
----------
S
-
A
Q
I
-
D
A
-
Y
L
T
---
D
-------
D
-
L
W
-
L
R
N
A
R
K
A
N
A
A
A
Q
R
L
A
Q
---
G
L
E
G
-
L
G
G
V
E
---
V
L
G
GT
E
A
N
I
L
F
C
R
L
D
-------
S
A
M
I
D
A
L
L
K
------
A
G
F
G
F
Y
H
D
R
-----
W
-----------
G
P
N
V
V
R
F
V
T
S
F
A
T
------
T
A
E
D
V
D
H
L
L
N
Q
V
R
L
A
A
----------------------------
5
PsiBlast_PDB
59.40
25%
-89
- C1 -
2FM1
3
?
A:
[40-300]
-------------------------------------------
D
V
Y
G
E
D
P
T
I
N
E
L
E
R
L
A
A
E
T
F
----
G
--------
K
----
E
--
A
-
A
--
L
F
V
-
P
S
G
T
M
G
N
Q
V
S
--
I
M
A
H
-
T
Q
R
------
G
D
--
E
V
I
L
E
A
D
S
H
I
F
W
Y
E
V
-
G
A
M
A
V
L
S
-
G
V
M
P
H
P
V
-
P
G
-
K
----
N
-----------
G
----
A
M
D
P
D
D
V
R
K
-
A
-------
I
--------
R
---------
P
RNIHFPR
T
S
L
I
A
I
E
N
T
H
N
R
S
G
G
R
V
V
P
L
E
N
I
K
E
I
C
T
I
A
K
E
H
G
--
I
N
V
H
I
D
G
A
R
I
F
N
A
S
-
I
A
S
--------
G
V
--
P
-
V
K
E
----
Y
A
---
G
Y
A
--
D
S
V
M
F
C
L
S
K
--
G
---
L
C
-
A
P
---
V
G
S
V
V
V
G
D
R
--
D
F
I
E
R
A
R
K
A
R
K
M
L
G
G
------
G
-
M
R
-
Q
A
G
V
L
----------
A
-
A
A
G
-
I
I
-
A
L
T
---
K
---
M
-
V
-
D
-
R
L
-
K
E
D
H
E
N
A
R
F
L
A
L
K
L
K
E
-
I
-
G
Y
S
V
-
N
P
E
D
V
---
K
T
N
--
M
V
I
L
R
T
D
N
-----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
58.66
25%
-88
- C1 -
1M6S
3
?
A:
[32-292]
-------------------------------------------
D
V
Y
G
E
D
P
T
I
N
E
L
E
R
L
A
A
E
T
F
----
G
--------
K
----
E
--
A
-
A
--
L
F
V
-
P
S
G
T
M
G
N
Q
V
S
--
I
M
A
H
-
T
Q
R
------
G
D
--
E
V
I
L
E
A
D
S
H
I
F
W
Y
E
V
-
G
A
M
A
V
L
S
-
G
V
M
P
H
P
V
-
P
G
-
K
----
N
-----------
G
----
A
M
D
P
D
D
V
R
K
-
A
-------
I
--------
R
---------
P
RNIHFPR
T
S
L
I
A
I
E
N
T
H
N
R
S
G
G
R
V
V
P
L
E
N
I
K
E
I
C
T
I
A
K
E
H
G
--
I
N
V
H
I
D
G
A
R
I
F
N
A
S
-
I
A
S
--------
G
V
--
P
-
V
K
E
----
Y
A
---
G
Y
A
--
D
S
V
M
F
C
L
S
K
--
G
---
L
C
-
A
P
---
V
G
S
V
V
V
G
D
R
--
D
F
I
E
R
A
R
K
A
R
K
M
L
G
G
------
G
-
M
R
-
Q
A
G
V
L
----------
A
-
A
A
G
-
I
I
-
A
L
T
---
K
---
M
-
V
-
D
-
R
L
-
K
E
D
H
E
N
A
R
F
L
A
L
K
L
K
E
-
I
-
G
Y
S
V
-
N
P
E
D
V
---
K
T
N
--
M
V
I
L
R
T
D
N
-----------------------------------------------------------------------------------------------------------------
35
HHSearch
58.61
14%
-82
- C1 -
3B1D
6
?
A:
[46-388]
-----------------------
M
P
E
V
K
Q
A
I
H
D
Y
---
A
E
Q
---
L
V
Y
G
Y
T
Y
A
S
D
E
L
L
Q
A
V
L
D
W
E
----
K
S
E
HQ
Y
S
F
D
K
----
E
--
D
-
I
--
V
F
V
-
E
G
V
V
P
A
I
S
I
A
I
Q
A
F
T
K
--
E
G
-------
E
--
A
V
L
I
N
S
P
V
Y
P
P
F
A
----
R
S
V
R
L
N
-
N
R
K
L
V
S
N
-
S
L
-
K
----
E
-----------
E
NG
L
F
Q
I
D
F
E
Q
L
E
N
-
D
I
V
-----
E
--------
N
---------
D
-------
V
K
L
Y
L
L
C
N
P
H
N
P
-
G
G
R
V
W
E
R
E
V
L
E
Q
I
G
H
L
C
Q
K
H
H
--
V
I
L
V
S
D
E
I
H
Q
D
L
T
L
-
F
G
H
--------
E
H
--
V
S
F
N
T
----
V
S
PDF
K
D
F
--
A
L
V
L
S
S
A
T
K
--
T
---
F
N
-
I
A
GT
K
N
S
Y
A
I
I
E
N
P
--
T
L
C
A
Q
F
K
H
Q
Q
L
V
N
N
H
------
H
-
E
---
V
S
S
L
----------
G
-
Y
I
A
T
E
T
-
A
Y
R
YG
K
P
---
W
-
L
-
V
-
A
L
K
A
V
L
E
E
N
I
Q
F
A
V
E
Y
F
A
Q
E
A
P
R
L
K
V
-
M
-
K
P
Q
---
G
T
Y
--
L
I
W
L
D
F
S
D
Y
G
-------
L
T
D
D
A
L
F
T
L
L
H
D
Q
A
K
V
I
L
N
R
G
S
D
Y
-----
G
-----------
S
E
G
E
L
H
A
R
L
N
I
A
A
-
P
K
-----
S
L
V
E
E
I
C
K
R
I
V
C
------------------------------
3
PsiBlast_PDB
58.41
25%
-90
- C1 -
1JG8
3
?
A:
[32-292]
-------------------------------------------
D
V
Y
G
E
D
P
T
I
N
E
L
E
R
L
A
A
E
T
F
----
G
--------
K
----
E
--
A
-
A
--
L
F
V
-
P
S
G
T
M
G
N
Q
V
S
--
I
M
A
H
-
T
Q
R
------
G
D
--
E
V
I
L
E
A
D
S
H
I
F
W
Y
E
V
-
G
A
M
A
V
L
S
-
G
V
M
P
H
P
V
-
P
G
-
K
----
N
-----------
G
----
A
M
D
P
D
D
V
R
K
-
A
-------
I
--------
R
---------
P
RNIHFPR
T
S
L
I
A
I
E
N
T
H
N
R
S
G
G
R
V
V
P
L
E
N
I
K
E
I
C
T
I
A
K
E
H
G
--
I
N
V
H
I
D
G
A
R
I
F
N
A
S
-
I
A
S
--------
G
V
--
P
-
V
K
E
----
Y
A
---
G
Y
A
--
D
S
V
M
F
C
L
S
K
--
G
---
L
C
-
A
P
---
V
G
S
V
V
V
G
D
R
--
D
F
I
E
R
A
R
K
A
R
K
M
L
G
G
------
G
-
M
R
-
Q
A
G
V
L
----------
A
-
A
A
G
-
I
I
-
A
L
T
---
K
---
M
-
V
-
D
-
R
L
-
K
E
D
H
E
N
A
R
F
L
A
L
K
L
K
E
-
I
-
G
Y
S
V
-
N
P
E
D
V
---
K
T
N
--
M
V
I
L
R
T
D
N
-----------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.04
24%
-93
- C1 -
1LW4
5
?
A:
[32-266]
-------------------------------------------
D
V
Y
G
E
D
P
T
I
N
E
L
E
R
L
A
A
E
T
F
----
G
--------
K
----
E
--
A
-
A
--
L
F
V
-
P
S
G
T
M
G
N
Q
V
S
I
M
A
H
T
Q
-
R
G
D
----------
E
V
I
L
E
A
D
S
H
I
F
W
Y
E
V
-
G
A
M
A
V
L
S
-
G
V
M
P
H
P
V
-
P
G
-
K
----
N
-----------
G
----
A
M
D
P
D
D
V
R
K
-
A
-------
I
--------
R
---------
P
RNIHFPR
T
S
L
I
A
I
E
N
T
H
N
R
S
G
G
R
V
V
P
L
E
N
I
K
E
I
C
T
I
A
K
E
H
G
--
I
N
V
H
I
D
G
A
R
I
F
N
A
S
-
I
A
S
--------
G
V
--
P
-
V
K
E
----
Y
A
---
G
Y
A
--
D
S
V
M
F
C
L
S
K
--
G
---
L
C
-
A
P
---
V
G
S
V
V
V
G
D
R
--
D
F
I
E
R
A
R
K
A
R
K
M
L
G
G
------
G
-
M
R
-
Q
A
G
V
L
----------
A
-
A
A
G
-
I
I
-
A
L
T
---
K
---
M
-
V
-
D
-
R
L
-
K
E
D
H
E
N
A
R
F
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.45
24%
-92
- C1 -
1LW5
4
?
A:
[32-266]
-------------------------------------------
D
V
Y
G
E
D
P
T
I
N
E
L
E
R
L
A
A
E
T
F
----
G
--------
K
----
E
--
A
-
A
--
L
F
V
-
P
S
G
T
M
G
N
Q
V
S
I
M
A
H
T
Q
-
R
G
D
----------
E
V
I
L
E
A
D
S
H
I
F
W
Y
E
V
-
G
A
M
A
V
L
S
-
G
V
M
P
H
P
V
-
P
G
-
K
----
N
-----------
G
----
A
M
D
P
D
D
V
R
K
-
A
-------
I
--------
R
---------
P
RNIHFPR
T
S
L
I
A
I
E
N
T
H
N
R
S
G
G
R
V
V
P
L
E
N
I
K
E
I
C
T
I
A
K
E
H
G
--
I
N
V
H
I
D
G
A
R
I
F
N
A
S
-
I
A
S
--------
G
V
--
P
-
V
K
E
----
Y
A
---
G
Y
A
--
D
S
V
M
F
C
L
S
K
--
G
---
L
C
-
A
P
---
V
G
S
V
V
V
G
D
R
--
D
F
I
E
R
A
R
K
A
R
K
M
L
G
G
------
G
-
M
R
-
Q
A
G
V
L
----------
A
-
A
A
G
-
I
I
-
A
L
T
---
K
---
M
-
V
-
D
-
R
L
-
K
E
D
H
E
N
A
R
F
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
57.39
15%
-95
- C1 -
1AX4
2
TNAA_PROVU
A:
[70-437]
-------------------------------------------
E
A
Y
A
G
S
R
N
Y
Y
D
L
K
D
K
A
K
E
L
F
----
N
--------
Y
----
D
--
Y
-
I
--
I
P
A
-
H
Q
G
R
G
A
E
N
I
L
F
P
V
L
L
K
--
Y
K
Q
K
E
GKA
K
N
--
P
V
F
I
S
N
F
H
F
D
T
T
A
----
A
H
V
E
L
N
-
G
C
K
A
I
N
I
-
V
T
-
E
----
K
AFDSETYDDWK
G
----
D
F
D
I
K
K
L
K
E
-
N
I
------
A
--------
Q
H
GAD-----
N
-------
I
V
A
I
V
S
T
V
T
C
N
S
A
G
G
Q
P
V
S
M
S
N
L
K
E
V
Y
E
I
A
K
Q
H
G
--
I
F
V
V
M
D
S
A
R
F
C
E
N
A
-
Y
F
I
K
A
RDPKYK
N
A
--
T
-
I
K
E
V
I
F
D
M
Y
---
K
Y
A
--
D
A
L
T
M
S
A
K
K
--
D
---
P
L
-
L
N
---
I
G
G
L
V
A
I
R
D
N
E
E
I
F
T
L
A
R
Q
R
C
V
P
M
E
G
------
F
V
T
Y
G
G
L
A
G
R
----------
D
M
A
A
M
-
V
Q
-
G
L
E
---
E
G
--
T
-
E
-
E
E
Y
L
-
H
Y
R
I
G
Q
V
K
Y
L
G
D
R
L
R
E
-
A
-
G
I
P
I
-
Q
-
Y
P
T
---
G
G
H
--
A
V
F
V
D
C
K
K
L
V
PQIPGDQ
F
P
A
Q
A
V
I
N
A
L
Y
L
E
S
G
V
R
A
V
E
I
G
S
F
-----
L
LGRDPATGEQK
H
A
D
M
E
F
M
R
L
T
I
A
R
R
V
Y
T
N
D
H
M
D
Y
I
A
D
A
L
I
G
L
--------------------------------
45
Fugue
55.46
20%
-76
- C1 -
1JG8
3
?
A:
[5-347]
----------
M
I
D
L
R
S
D
T
V
T
K
P
T
E
E
M
R
K
A
M
A
Q
A
-
E
V
G
--
D
---
D
V
Y
G
E
D
P
T
I
N
E
L
E
R
L
A
A
E
T
F
----
G
--------
K
----
E
--
A
-
A
--
L
F
V
-
P
S
G
T
M
G
N
Q
V
S
I
M
A
H
---
T
Q
R
------
G
D
--
E
V
I
L
E
A
D
S
H
I
F
W
Y
E
V
-
G
A
M
A
V
L
S
-
G
V
M
P
H
P
V
-
P
G
-
K
---------------------
N
G
A
M
D
P
D
D
V
-
R
-------
K
--------
A
IRPRNIHFP
R
-------
T
S
L
I
A
I
E
N
T
H
N
R
S
G
G
R
V
V
P
L
E
N
I
K
E
I
C
T
I
A
K
E
H
G
--
I
N
V
H
I
D
G
A
R
I
F
N
A
-
S
I
A
S
--------
G
V
--
P
-
V
K
E
----
Y
A
---
G
Y
A
--
D
S
V
M
F
C
L
S
K
---GLC
A
P
--
V
---
G
S
V
V
V
G
D
-----
R
D
F
I
E
R
A
R
K
A
R
K
M
L
----------------GGGMRQ
A
G
V
L
A
-
A
A
G
-
I
I
-
A
L
T
---
K
---
M
-
V
-
D
-
R
L
-
K
E
D
H
E
N
A
R
F
L
A
L
K
L
K
E
-
I
-
G
Y
S
V
-
N
--
P
E
DVK-
T
N
--
M
V
I
L
R
T
D
N
L
K
-------
V
-
N
A
H
G
F
I
E
A
L
R
N
S
G
V
L
A
N
A
V
S
--------------------------------------------------
D
T
E
I
R
L
V
T
HKDV
S
R
N
D
I
E
E
A
L
N
I
F
E
K
L
F
R
KFS
7
PsiBlast_PDB
52.98
25%
-80
- C1 -
4LNJ
4
?
A:
[28-263]
-------------------------------------------
D
V
Y
G
D
D
P
T
V
N
A
L
Q
D
Y
A
A
E
L
S
----
G
--------
K
----
E
--
A
-
A
--
I
F
L
-
P
T
G
T
Q
A
N
L
V
A
L
L
S
H
C
E
-
R
G
E
------
E
Y
--
I
V
G
Q
--
A
A
H
N
Y
L
F
E
A
-
G
G
A
A
V
L
G
-
S
I
Q
P
Q
P
I
D
A
A
-
A
----
D
-----------
G
----
T
L
P
L
D
K
V
A
M
-
K
-------
I
--------
K
---------
P
DDIHF--
A
R
T
K
L
L
S
L
E
N
T
H
N
G
K
V
L
P
R
-
E
Y
L
K
E
A
W
E
F
T
R
K
R
N
--
L
A
L
H
V
D
G
A
R
I
F
N
A
V
-
V
A
Y
--------
G
C
--
E
-
L
K
E
----
I
T
---
Q
Y
C
--
D
S
F
T
I
C
L
S
K
--
G
---
L
G
-
T
P
---
V
G
S
L
L
V
G
N
R
--
D
Y
I
K
R
A
I
R
W
R
K
M
T
G
G
------
G
-
M
R
-
Q
S
G
I
L
----------
A
-
A
A
G
-
M
Y
-
A
L
K
---
N
---
N
-
V
-
A
-
R
L
-
Q
E
D
H
D
N
T
A
W
M
A
E
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
52.77
16%
-81
- C1 -
1ECX
2
?
A:
[1-376]
M
R
V
Y
F
D
N
N
-
A
T
T
R
-----
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
Y
G
N
P
N
S
AH
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
----
G
--------
V
----
S
--
P
-
S
E
I
F
F
T
-
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
-
T
F
E
------
K
R
KR
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
K
G
-
F
K
V
K
Y
V
P
-
V
D
-
S
----
R
-----------
G
----
V
V
K
L
E
E
L
E
K
L
V
-------
D
--------
E
---------
D
-------
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
----
V
E
D
V
T
R
I
V
K
K
K
N
KE
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
-
P
F
S
--------
L
E
--
K
-
L
E
------------
V
--
D
Y
A
S
F
S
A
H
K
FH
G
---
P
K
-
G
V
----
G
I
T
Y
I
R
K
G
--
V
P
I
R
P
L
I
H
G
G
G
Q
E
R
G
LRSGTQ
N
-
V
P
-
G
I
V
G
A
----------
A
-
R
A
M
-
E
I
-
A
V
E
---
E
---
L
-
S
-
E
-
A
A
-
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
-
L
G
A
H
I
I
T
P
L
E
I
S
---
L
P
N
--
T
L
S
V
S
F
P
N
I
R
----------
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
H
V
L
D
A
M
GVD
R
-----------
R
I
A
Q
G
A
I
R
I
S
L
C
K
-
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
----------------------------
33
HHSearch
52.68
14%
-73
* C1 *
3L8A
2
?
A:
[75-417]
----------------------
P
V
P
E
I
K
E
A
I
I
N
Y
-
G
R
E
H
I
---
F
G
Y
--
N
Y
F
N
D
D
L
Y
Q
A
V
I
D
W
E
R
K
EH
D
--------
Y
A
V
V
K
E
--
D
-
I
--
L
F
I
-
D
G
V
V
P
A
I
S
I
A
L
Q
A
F
S
E
--
K
G
-------
D
--
A
V
L
I
N
S
P
V
Y
Y
P
F
A
R
----
T
I
R
L
N
-
D
H
R
L
V
E
N
-
S
L
-
Q
I
I
NG
R
-----------
F
----
E
I
D
F
E
Q
L
E
K
-
D
I
------
I
D
-------
N
---------
N
-------
V
K
I
Y
L
L
C
S
P
H
N
P
-
G
G
R
V
W
D
N
D
D
L
I
K
I
A
E
L
C
K
K
H
G
--
V
I
L
V
S
D
E
I
H
Q
D
L
A
L
-
F
G
N
--------
T
H
--
H
S
L
N
T
----
L
D
ASY
K
D
F
--
T
I
I
L
S
S
A
T
K
--
T
---
F
N
I
A
G
T
K
-
N
S
F
A
I
I
Q
N
E
--
S
L
R
R
K
F
Q
Y
R
Q
L
A
N
N
Q
---------
H
-
E
V
P
T
V
----------
G
-
M
I
A
-
T
Q
A
A
F
Q
---
Y
G
K
P
W
-
L
-
E
-
E
L
K
T
V
I
E
G
N
I
K
L
V
I
K
E
L
E
A
-
K
T
K
I
K
V
-
M
-
E
P
E
---
G
T
Y
--
L
V
W
L
D
F
S
A
Y
A
-------
I
A
Q
P
Q
L
S
E
K
L
Q
N
E
A
K
V
V
L
N
D
G
A
H
F
-----
G
-----------
K
E
G
K
Y
F
A
R
L
N
V
A
T
-
P
-----
K
N
T
V
Q
E
A
L
S
R
I
I
S
------------------------------
12
PsiBlast_PDB
52.25
25%
-75
- C1 -
4RJY
6
?
A:
[28-263]
-------------------------------------------
D
V
Y
G
D
D
P
T
V
N
A
L
Q
D
Y
A
A
E
L
S
----
G
--------
K
----
E
--
A
-
A
--
I
F
L
-
P
T
G
T
Q
A
N
L
V
A
L
L
S
H
C
E
-
R
G
E
------
E
Y
--
I
V
G
Q
--
A
A
H
N
Y
L
F
E
A
-
G
G
A
A
V
L
G
-
S
I
Q
P
Q
P
I
D
A
A
-
A
----
D
-----------
G
----
T
L
P
L
D
K
V
A
M
-
K
-------
I
--------
K
---------
P
DDIHF--
A
R
T
K
L
L
S
L
E
N
T
H
N
G
K
V
L
P
R
-
E
Y
L
K
E
A
W
E
F
T
R
K
R
N
--
L
A
L
H
V
D
G
A
R
I
F
N
A
V
-
V
A
Y
--------
G
C
--
E
-
L
K
E
----
I
T
---
Q
Y
C
--
D
S
F
T
I
C
L
S
K
--
G
---
L
G
-
T
P
---
V
G
S
L
L
V
G
N
R
--
D
Y
I
K
R
A
I
R
W
R
K
M
T
G
G
------
G
-
M
R
-
Q
S
G
I
L
----------
A
-
A
A
G
-
M
Y
-
A
L
K
---
N
---
N
-
V
-
A
-
R
L
-
Q
E
D
H
D
N
T
A
W
M
A
E
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
52.09
26%
-75
- C1 -
3WLX
2
LTAE_ECOLI
B:
[28-263]
-------------------------------------------
D
V
Y
G
D
D
P
T
V
N
A
L
Q
D
Y
A
A
E
L
S
----
G
--------
K
----
E
--
A
-
A
--
I
F
L
-
P
T
G
T
Q
A
N
L
V
A
L
L
S
H
C
E
-
R
G
E
------
E
Y
--
I
V
G
Q
--
A
A
H
N
Y
L
F
E
A
-
G
G
A
A
V
L
G
-
S
I
Q
P
Q
P
I
D
A
A
-
A
----
D
-----------
G
----
T
L
P
L
D
K
V
A
M
-
K
-------
I
--------
K
---------
P
DDIHF--
A
R
T
K
L
L
S
L
E
N
T
H
N
G
K
V
L
P
R
-
E
Y
L
K
E
A
W
E
F
T
R
E
R
N
--
L
A
L
H
V
D
G
A
R
I
F
N
A
V
-
V
A
Y
--------
G
C
--
E
-
L
K
E
----
I
T
---
Q
Y
C
--
D
S
F
T
I
C
L
S
K
--
G
---
L
G
-
T
P
---
V
G
S
L
L
V
G
N
R
--
D
Y
I
K
R
A
I
R
W
R
K
M
T
G
G
------
G
-
M
R
-
Q
S
G
I
L
----------
A
-
A
A
G
-
I
Y
-
A
L
K
---
N
---
N
-
V
-
A
-
R
L
-
Q
E
D
H
D
N
A
A
W
M
A
E
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------