@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0309: (2016-03-14 )
MSIINSNFRSLGSYIMENIYKIPNYQREYSWEETELEDLWMDLSQIINGETESHFFGQIVIHVDKKEKAKLIIDGQQRTSTAVIFLAAMRELFTEMYNAGWDDAQFDAQDITTKFIGRYTQTRDERKLILGENDKSYFSNRIQSVSSEQLGLQKATKSQKRINFAYNYFYKKLEEEINSSDFLEDKYGLLKTFFSTFTEKCSVMFVETDDFNEAFIIFETLNARGKDLETADLLKNHLFKIANKKVGEVKKNWKQMLEFIGTVDTTKYIRHFWNSQNVFIREKDLYKEIRKKITTQFEAIIFIDDLVRLSEVYGGMKNPAEDNFFETDSQQVLNDLKRLGAKSFYPIILAMVKKDYGPNEIYEVLSAIEVLVVRNFVISGLVANKYETEFSKIAFKIYQEEVESVTEIINLIRTNIIADDVFLNNFSSFKTTNKLRLRYILKKINDSYSKEIAVLNDNNKIHLEHIMPIKADGWDIIKEEHEEYLWKIGNLTLLGSEYNKKSTNKIFNDKKDIYEYSEVQLTRKLLDYDEWNIDVIKERQVELAELAVNIWKV
Atome Classification :
(20 SA)
-------......---.--.--.10.........20........30........40----.....--------..-----..50........60.......-.70......------------..80.......-------.90....---------....100.......110----------........120.......-130...------....140.......150-------------........160.--------...---...170.......180.....-.-----.190------...--------....--------------------.200.-......210.......220....--...230.-------------.....-----.240.....-----..250--------.------......260---...--.....270.---------......280--..--.....290--.------...-.--...300......-----.310..-...-..-320........330---.........340---...--.----------------.---..------350...-------------....360-----....-.....-----370..----.-----..---..380.....---------.-.-390...-------...--.400.......410.-----.-----...--..420.-----------......-------430-----........440.......450-.--....-..460--------.--.-----.-...---..470.....-------..480......-------------.490.....------------------------------..500....--...510...-------------------....520--.......530.......540.......550.-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MS
I
I
N
S
---
N
--
F
--
R
S
-
L
G
S
Y
I
M
E
N
I
Y
KIPN
Y
Q
REYSWEE
T
E
L
E
D
L
W
-----
M
D
L
S
Q
--------II-----NGETE
S
H
F
F
G
Q
I
V
I
H
VDKKEK-
A
K
L
I
I
DGQQ------------RT
S
T
A
V
I
F
L
A
A
-------
M
R
E
L
F
T
E
---------
M
Y
NAGWDDAQF
D
A
Q
D
-
I
----------
T
T
K
F
I
G
R
Y
TQTRDE
R
K
L
I
-LGEN
D
K
------
S
Y
F
S
N
R
I
Q
S
V
S
S
E
Q
L
G
--------------
L
Q
K
ATKSQ
K
R
I
N
--------
F
A
Y
---
N
Y
F
Y
K
K
L
E
E
EINSSD
F
L
E
D
K
Y
-
G
-----
L
L
K
-------
T
F
F
--------
S
T
F
T--------------------EK
C
S
V
-
M
F
V
ETDDFN
E
A
F
I
I
F
E
TLNARGK--DL
E
T
A
D
L
-------------
L
K
N
H
L
-----
F
K
I
A
N
K
K
V
G
-----
E
V
K
K
N
--------
W
------
K
Q
M
L
E
F
IG----TV
D
--
T
T
K
Y
I
R
H
F
W---------NSQ
N
V
F
I
R
E
--
K
D
--
L
Y
K
E
I
R
K
---
K
------
I
T
T
-
Q
--
F
E
A
I
I
F
I
D
D
L
V
R
-----
L
S
E
V
YG-GMK-NP-AE-DNFFET
D
S
Q
-----
Q
V
L
N
D
L
K
R
LGAK---
S
F
Y
--
P
----------------
I
---
I
L
------
A
M
V
KKD-------------Y
G
P
N
E
-------
I
Y
E
V
-
L
S
A
I
E
-----
V
L
V
V
R
----
N
-----
F
V
---
I
S
G
L
VAN
K
Y
E
---------
T
-
E
-
F
S
K
I
A
F
-------
K
I
Y
--
Q
E
E
V
E
S
V
T
E
I
I
N
L
I
R
-----
T
-----
N
II--A
D
D
V
F
L-----------NN
F
S
SF-------KT------T
N
K
L
R
L
R
Y
I
L
K
K
INDSYS
K
E
I
-
A
--
V
LND-N
N
K
I
---------
H
--
L
-----
E
-
H
IM---PIKAD
G
W
D
I
I
-------
K
E
E
H
E
E
Y
L
W
K
I-------------G
N
L
T
L
LGSE------------------------------YNKKS
T
N
K
I--FND
K
K
D
I
Y
E
-------------------
Y
S
E
V
Q
L
T
--
R
K
L
LDYDEWN
I
D
V
I
K
E
R
Q
V
E
L
A
E
L
A
V
N
IWKV-----------------
37
Fugue
83.81
14%
-36
- C4 -
4M59
3
?
A:
[6-714]
PD
A
Q
V
L
V
L
A
I
S
S
H
---
P
--
L
--
P
T
-
L
A
A
F
L
A
S
R
R
D
E
L
L
R
A
D
I
T
S
L
L
K
A
L
E
L
S
G
H
W
-----
E
W
A
L
A
--------
L
L
R
W
A
G
K
E
G
A
A
D
A
S
A
L
E
M
V
V
R
A
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Q
-
H
D
A
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C
A
L
L
D
ETPLPPG
S
R
L
D
V
R
A
Y
T
T
V
L
H
A
L
S
R
A
GR
Y
E
R
A
L
E
L
F
A
E
---------
L
R
R
Q
G
-
V
A
P
T
L
V
T
Y
N
-
V
----------
V
L
D
V
Y
G
R
M
G
R
S
W
P
R
I
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A
L
-
L
D
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M
R
A
A
G
V
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G
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A
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T
V
I
A
A
C
S
R
D
G
L
--------------
V
D
E
A
V
A
F
F
E
D
L
K
A
R
GHAPS
V
V
T
Y
---
N
A
L
L
Q
V
F
G
K
A
G
N
Y
T
E
A
L
R
V
L
G
-
E
-----
M
E
Q
N
G
C
Q
P
D
A
V
T
Y
--------
N
E
L
A
G
TE
E
A
A
R
C
L
D
T
M
A
SPN
A
F
T
Y
N
T
V
M
T
-
A
Y
G
N
V
G
K
V
D
E
A
L
A
L
F
D
Q
M
K
K
T
G
F
V
P
N
V
N
T
Y
N
L
-------------
V
L
G
M
L
G
K
K
SR
F
T
V
M
L
E
M
L
G
-----
E
M
S
R
S
G
C
T
P
N
R
V
T
W
------
N
T
M
L
A
V
S
G
----
K
R
G
--
M
E
D
Y
V
T
R
V
L
---------
E
G
M
R
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S
G
V
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L
S
R
D
--
T
Y
N
T
L
I
A
A
Y
G
R
------
C
G
S
-
R
--
T
N
A
F
K
M
Y
N
E
M
T
S
A
G
F
T
P
C
I
T
T
Y
N
-
A
L
L
-
N
V
-
L
S
-
R
Q
G
D
W
S
T
A
Q
-----
S
I
V
S
K
M
R
T
K
G
F
K
P
N
E
Q
S
Y
--
S
----------------
L
---
L
L
------
Q
C
Y
A
K
G
GN
V
A
G
I
A
A
I
E
N
E
V
Y
G
S
G
A
-------
V
F
P
S
-
W
V
I
L
R
-----
T
L
V
I
A
----
N
-----
F
K
C
RR
L
D
G
M
E
T
A
F
Q
E
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K
A
RG
Y
N
P
D
L
-
V
-
I
F
N
S
M
L
-------
S
I
Y
A
K
N
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M
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K
A
T
E
V
F
D
S
I
K
-----
R
S
G
L
S
P
D
L
I
--
T
Y
N
S
L
M
-----------
D
M
Y
A
K
C
SE
S
W
E
A
E
K
I
------
L
N
Q
L
K
C
S
Q
T
M
K
P
D
V
V
S
Y
N
T
V
I
-
N
--
G
F
C
K
-
Q
G
L
V
---------
K
E
A
Q
-----
R
-
V
L
S
---
E
M
V
A
D
G
M
A
P
C
-------
A
V
T
Y
H
T
L
V
G
G
Y
-------------
S
S
L
E
M
F
S
E
A
--------------------------------
R
E
V
I
G
Y
M
--
V
Q
H
G
L
K
P
M
E
-------------------
L
T
Y
R
R
V
V
--
E
S
Y
C
R
A
F
E
E
A
R
G
F
L
S
E
V
K
A
L
E
A
Y
I
E
D
A
---------------------
45
Fugue
82.06
17%
39
- C3 -
4RDR
28
?
A:
[32-748]
-----------
S
R
---
P
--
R
--
A
T
-
S
G
L
L
H
T
S
T
A
S
D
K
I
I
S
G
D
T
L
R
Q
K
A
V
N
L
G
D
A
L
DGVPG
I
H
A
S
Q
YGGG
A
S
A
P
V
I
-----
R
G
Q
T
G
R
R
I
--
K
V
L
N
H
H
G
E
T
G
D
M
A
D
F
S
P
D
H
A
I
M-----------
V
D
T
A
L
S
Q
Q
V
E
I
-------
L
R
G
P
V
T
L
---------
L
Y
S
S
G
N
V
A
G
L
V
D
V
A
D
-
G
KIPE
K
M
P
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NG
V
S
G
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L
G
L
R
L
S
S
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N
L
E
K
L
T
-
S
G
G
I
N
I
------
G
L
G
K
N
F
V
L
H
T
E
G
L
Y
R
K
S
G
D
Y
A
V
P
RYRNLKR
L
P
D
S
H
A
D
S
Q
T
G
S
--------
I
G
L
---
S
W
V
G
E
K
G
F
I
G
V
A
Y
S
D
-
R
R
D
Q
Y
-
G
-----
L
P
A
-------
H
----------
S
H
E
Y
--------------------
D
D
C
H
A
D
I
I
W
Q
K
S
L
I
N
K
R
Y
L
Q
L
Y
P
H
L
L
T
E
E
--
D
I
D
Y
D
N
P
G
L
S
C
GHS
G
R
P
W
I
D
L
R
N
K
R
-----
Y
E
L
R
A
E
W
K
Q
PFPGF
E
A
L
R
V
--------
H
------
L
N
R
N
D
Y
R
H
----
D
E
K
--
A
G
D
A
V
E
N
F
F
---------
N
N
Q
T
Q
N
A
R
I
--
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--
R
H
Q
P
I
-
G
---
R
------
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S
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Y
L
Q
Q
K
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S
A
-----
L
S
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Q
P
M
L
L
-
D
N
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H
Y
S
F
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V
E
Q
A
N
W
D
N
F
T
L
E
G
G
V
---
R
V
E
--
K
----------------
Q
---
K
A
S
I
Q
Y
D
K
A
L
I
D
R
E
-------------
N
Y
Y
N
H
-------
P
L
P
D
-
L
G
A
-
H
-----
R
Q
T
A
R
----
S
-----
F
A
---
L
S
G
N
W
Y
F
T
P
Q
---------
H
-
K
-
L
S
L
T
A
S
-------
H
----
Q
E
R
L
P
S
T
Q
E
L
Y
A
H
G
K
-----
H
-------
V
--
A
T
N
T
F
E
V
G
N
KHLNKE
R
S
N
N
I
E
L
A
-------
L
G
------
Y
E
G
D
R
W
Q
Y
N
L
A
L
Y
R
N
R
F
G
N
Y
I
-
Y
A
Q
T
L
N
D
-
G
R
G
P
---------
K
--
S
IEDDS
E
M
K
L
V
---
R
Y
N
Q
S
G
A
D
F
Y
-------
G
A
E
G
E
I
Y
F
K
P
T
PR
Y
R
I
G
V
S
G
D
Y
V
R
G
R
L
K
N
L
P
S
L
P
G
R
EDAYG
N
R
P
F
I
A
Q
D
D
Q
N
A
P
RVP
A
A
R
L
G
F
H
L
K
A
S
L
T
D
R
--
I
D
A
N
L
D
Y
Y
R
V
F
A
Q
NKLARYE
T
R
T
P
G
H
H
M
L
N
L
G
A
N
Y
--
R
R
N
T
R
Y
G
E
W
N
W
Y
V
K
A
D
N
L
L
N
Q
S
V
Y
A
H
S
S
F
L
S
DTPQMG
R
S
F
T
G
G
V
N
V
K
F
41
Fugue
74.88
15%
-26
- C7 -
1JVN
4
HIS5_YEAST
A:
[1-555]
-GSH
M
P
V
V
H
V
I
D
V
ESG
N
--
L
--
Q
S
-
L
T
N
A
I
E
H
L
G
Y
E
V
Q
L
V
K
S
P
K
D
F
N
I
S
G
T
S
R
L
I
-----
L
P
----------------------
G
V
G
N
Y
G
H
F
V
D
N
L
F
N
R
G
F
-
E
K
P
I
R
E
Y
I
E
-------------
S
G
K
P
I
M
G
I
V
G
-------
L
Q
A
L
F
A
G
SVESPKSTG
L
N
Y
I
D
F
K
L
S
R
F
D
D
S
E
-
K
----------
P
V
P
E
I
G
W
N
S
C
I
P
S
E
N
L
F
F
G
L
D
P
Y
K
R
------
Y
Y
F
V
H
S
F
A
A
I
L
N
S
E
K
K
--------------
K
N
L
E
N
D
G
W
K
I
A
K
--------
A
K
Y
GS
E
E
F
I
A
A
V
N
K
N
N
I
F
A
T
Q
F
H
P
E
K
S
-
G
K
A
G
L
N
V
I
E
-------
N
F
L
K
QQSPPIP
N
Y
S
A
--------------------
E
E
K
E
L
-
L
M
N
D
Y
S
N
Y
G
L
T
R
R
I
I
A
C
L
D
V
R
T
N
--
D
--------------------
Q
G
D
L
-----
V
V
-
T
K
G
D
L
G
-----
K
P
V
Q
L
--------
A
------
Q
K
Y
Y
Q
--
Q
----
G
A
D
------
E
V
T
F
L
---------
N
I
T
D
C
P
L
K
D
--
T
P
--
M
L
E
V
L
K
Q
---
A
------
A
K
T
-
V
--
F
V
P
L
T
V
G
---------------
G
-
G
I
K
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D
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D
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T
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P
A
L
-----
E
V
A
S
L
Y
F
R
S
G
A
D
---
K
V
S
I
G
T
----------------
D
---
A
V
------
Y
A
A
E
K
Y
-------------
Y
E
L
G
N
-------
R
G
D
G
-
T
S
P
I
E
-----
T
I
S
K
A
YGAQ
A
-----
V
V
---
I
S
V
D
P
K
R
V
Y
V
---------
N
-
S
-
Q
A
D
T
K
N
-------
K
V
F
--
E
T
E
Y
P
G
P
N
G
-----------
E
-----
K
Y
C
--
W
Y
Q
C
T
I
-----------
K
G
G
----------
R
E
------
S
R
D
L
G
V
W
E
L
T
R
A
C
E
A
L
G
A
G
E
I
-
L
--
L
N
C
I
-
D
K
----------------------------
D
G
S
N
S
G
Y
D
----------
L
E
L
I
E
H
V
K
D
A
-------------
V
K
I
P
V
I
A
S
S
GA----------------------------
G
V
P
E
H
F
E
E
A
--
F
L
K
T
R
------------------------
A
D
A
C
L
G
--
A
G
M
F
H
R
G
E
F
T
V
N
D
V
K
E
Y
L
L
E
-
H
G
L
K
V
R
M
D
E
E
-----------------
39
Fugue
61.77
11%
-19
- C5 -
1JIH
-
POLH_YEAST
A:
[1-509]
-------
M
S
------------------
K
F
T
W
K
E
L
I
Q
L
G
S
P
S
K
A
Y
E
S
S
L
A
C
I
A
H
I
D
-----
M
N
------------------------
A
F
F
A
Q
V
E
Q
M
R
C
G
L
S
K
-
E
D
P
V
V
C
V
Q
W
------------
N
S
I
I
A
V
S
Y
A
A
R
-------
K
Y
G
I
S
R
M
---------
D
---
T
I
Q
E
A
L
K
K
C
S
N
-
L
----------
I
P
I
H
T
A
V
F
K
K
G
E
D
F
W
Q
Y
H
-
D
G
C
G
S
W
------
V
Q
D
P
A
K
Q
I
S
V
E
D
H
K
V
S
--------------
L
E
P
Y
R
R
E
S
R
K
A
L
--------
K
I
F
---
K
S
A
C
D
L
V
E
R
A
S
I
D
E
V
F
L
D
---------------------------------
L
G
--------------------
R
I
C
F
N
-
M
L
M
F
D
N
E
Y
E
L
T
G
D
L
--
K
L
K
D
A
L
S
--
N
I
R
E
A
F
I
-------------
G
G
N
Y
D
--------
I
N
S
H
L
P
-----
L
I
P
E
K
--------
I
------
K
S
L
K
F
E
G
D
----
V
F
N
--
P
E
G
R
D
L
I
T
D
---------
W
D
D
V
I
L
A
L
G
--
S
Q
--
V
C
K
G
I
R
D
---
S
------
I
K
D
-
I
LG
Y
T
T
S
C
G
L
S
S
T
K
N
-----
V
C
K
L
A
S
-
N
Y
K
-
K
P
-
D
A
-
Q
T
I
V
K
N
D
C
L
-----
L
D
F
L
D
C
G
K
F
E
I
T
---
S
F
W
--
T
----------------
L
GG
V
L
G
------
K
E
L
I
D
V
-------------
L
D
L
P
H
-------
E
N
S
I
-
K
H
I
R
E
T
WPDN
A
G
Q
L
K
----
E
-----
F
L
---
D
A
K
V
K
Q
S
D
Y
D
---------
R
-
S
-
T
S
N
I
D
P
-------
L
K
T
--
A
D
L
A
E
K
L
F
K
L
S
R
G
R
Y
-----
G
-----
L
P
L
--
S
S
R
P
V
V
-----------
K
S
M
M
S
N
-------
K
N
LRGKSC
N
S
I
V
D
C
I
S
W
L
E
V
F
C
A
E
L
T
S
R
I
-
Q
--
D
L
E
Q
E
Y
N
K
I
---------
V
--
I
-----
P
-
R
T
V
---
S
I
S
L
K
T
K
S
Y
E
-------
V
Y
R
K
S
G
P
V
-----------------------------------------------------------
A
Y
K
G
I
--
N
F
Q
S
H
E
L
L
K
-------------------
V
G
I
K
F
V
T
--
D
L
D
I
K
G
K
N
K
S
Y
Y
P
L
T
K
L
S
M
T
I
T
N
F
D
I
I
---------------------
46
Fugue
57.55
16%
-8
- C6 -
4N0N
9
A:
[22-422]
----SAV
C
T
V
C
G
A
---
A
PV
A
--
K
S
A
C
G
G
W
F
C
G
N
C
-------
V
P
Y
H
A
G
H
C
H
T
T
S
L
F
-----
A
N
C
G
H
--------
D
I
-----
M
Y
R
S
T
Y
C
T
M
-----------------
C
E
G
S
P
------------
K
Q
M
V
P
K
V
P
H
P
I
-------
L
D
H
L
L
C
H
---------
I
D
Y
G
S
K
E
E
L
T
L
V
V
A
D
G
R
----------
T
T
S
P
P
G
R
Y
K
V
---
G
H
K
V
V
-
A
V
V
A
D
V
------
G
--
G
N
I
V
F
G
C
G
P
G
S
H
I
--------------
A
V
P
L
Q
D
T
L
K
G
V
V
-----------------
V
N
K
A
L
K
N
A
A
A
S
E
Y
V
E
G
P
P
-
G
-----
S
G
K
-------
T
F
H
--------
L
V
K
D
--------------------
V
L
A
V
V
---------
G
S
A
T
L
V
V
P
T
------------------------------------------------------
H
A
S
--------
M
------
L
D
C
I
N
K
L
K
----
Q
A
G
--
A
D
P
Y
F
V
V
P
K
---------
Y
T
V
L
D
F
P
R
P
--
G
S
--
G
N
I
T
V
R
L
---
P
------
Q
V
G
-
T
--
S
E
G
E
T
F
V
D
E
V
A
Y
-----
F
S
----------
P
-
V
D
L
A
R
I
L
T
Q
G
R
V
-----
K
G
Y
G
D
L
N
Q
L
G
C
V
---------------------------------------------------------
G
P
A
S
------------------------
V
P
R
----
N
-----
L
W
---
L
R
H
F
V
S
L
E
P
L
---------
R
-
V
-
C
H
R
F
G
--------------------
A
A
V
C
D
L
I
K
------------------
G
I
Y
P
-----------
Y
Y
E
P
A
P
-------
H
T
------
T
K
V
V
F
V
P
------
N
P
D
F
E
K
G
V
-
V
--
I
T
A
Y
-
H
K
D
R
---------
G
--
L
-----
G
-
H
R
T
---
I
D
S
I
Q
G
C
T
-----------------
F
P
V
-------------
V
T
L
R
L
--------------------------------------
P
T
P
Q
S
--
L
T
R
P
R
A
V
V
A
-------------------
V
--
T
R
A
S
--
Q
E
L
Y
I
Y
D
P
F
D
---------
Q
L
S
G
L
L
K
F
---------------------
15
PsiBlast_PDB
56.05
20%
-58
- C8 -
2Z82
2
TLR2_MOUSE
A:
[76-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
H
L
D
L
-------------
S
D
N
H
L
-----
S
S
L
S
S
S
W
F
G
-----
P
L
S
S
----------------
L
K
Y
L
N
L
M
G
NPYQ
T
L
G
--
V
T
S
L
F
P
N
L
T
---------
N
L
Q
T
L
R
I
G
N
--
V
E
--
T
F
S
E
I
R
R
------------
I
-
D
--
F
A
G
L
T
S
L
N
E
L
---------
E
I
K
A
L
S
L
R
-
N
--------
Y
Q
S
Q
S
L
-----
K
S
I
R
D
I
H
H
L
--------------------------------
T
L
------
H
L
S
E
S
A
-------------
F
L
L
E
I
-------
F
A
D
I
-
L
S
S
V
R
-----
Y
L
E
L
R
----
D
TNLAR
F
Q
---
F
S
P
L
P
V
D
E
V
S
---------
S
-
P
-
M
K
K
L
A
F
-------
R
G
S
--
V
L
T
D
E
S
F
N
E
L
L
K
L
L
R
YILEL
S
-----
E
V
E
--
F
D
D
C
T
L
-----------
N
G
L
G
D
F
-------
N
P
------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
55.24
20%
-58
- C8 -
2Z81
2
TLR2_MOUSE
A:
[76-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
H
L
D
L
-------------
S
D
N
H
L
-----
S
S
L
S
S
S
W
F
G
-----
P
L
S
S
----------------
L
K
Y
L
N
L
M
G
NPYQ
T
L
G
--
V
T
S
L
F
P
N
L
T
---------
N
L
Q
T
L
R
I
G
N
--
V
E
--
T
F
S
E
I
R
R
------------
I
-
D
--
F
A
G
L
T
S
L
N
E
L
---------
E
I
K
A
L
S
L
R
-
N
--------
Y
Q
S
Q
S
L
-----
K
S
I
R
D
I
H
H
L
--------------------------------
T
L
------
H
L
S
E
S
A
-------------
F
L
L
E
I
-------
F
A
D
I
-
L
S
S
V
R
-----
Y
L
E
L
R
----
D
TNLAR
F
Q
---
F
S
P
L
P
V
D
E
V
S
---------
S
-
P
-
M
K
K
L
A
F
-------
R
G
S
--
V
L
T
D
E
S
F
N
E
L
L
K
L
L
R
YILEL
S
-----
E
V
E
--
F
D
D
C
T
L
-----------
N
G
L
G
D
F
-------
N
P
------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
54.05
20%
29
* C7 *
4OVY
9
?
A:
[1-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
P
L
P
S
--------
W
NDS
A
A
R
R
A
I
L
E
Y
V
K
----
S
V
T
--
T
E
G
S
P
R
F
V
P
---------
V
S
E
R
I
V
T
F
D
--
N
D
GT
L
W
C
E
--------------
Q
P
M
Y
--
V
Q
L
A
F
A
L
D
R
V
R
L
-----
L
A
D
K
H
P
-
E
W
R
-
T
E
-
E
P
-
F
R
A
V
I
E
K
D
--------
L
P
A
L
A
K
L
G
A
K
---
G
L
T
--
E
L
T
M
A
T
HAGMT
D
D
E
F
E
N
I
---
V
T
------
E
W
I
R
K
A
-------------
R
H
P
K
F
HRPYTEC
V
Y
Q
P
M
L
E
L
L
A
-----
F
L
R
Q
H
----
E
-----
F
K
---
T
F
I
V
S
G
A
G
I
E
---------
F
M
R
P
W
A
K
E
V
Y
-------
G
I
P
--
P
E
Q
V
I
G
S
S
V
K
L
K
Y
E
L
-----
R
-----
D
G
K
--
P
V
L
V
R
L
-----------
A
E
L
N
-
F
-------
I
D
------
D
Q
A
G
K
P
V
G
I
R
Q
V
I
G
---
R
R
P
V
M
A
--
V
G
N
S
-
D
G
D
Y
---------
E
M
-
L
-----
E
-
Y
V
T
---
S
G
P
A
N
G
L
G
L
I
V
H
HTDAV
R
E
F
A
Y
D
R
Q
S
P
F
-------------
G
R
L
D
R
A
L
T
D
------------------------------
A
T
S
K
G
W
I
V
I
DM
Q
R
D
W
K
V
I
F
P
-------------------
E
S
-------------------------------------------------------
40
Fugue
52.46
9%
-16
- C7 -
1LTX
1
RAE1_RAT
R:
[2-614]
-------
A
D
N
L
P
S
---
D
--
F
DV
I
V
-
I
G
T
G
L
P
E
S
I
I
A
A
A
C
S
R
S
-----------------------------------------------
G
Q
R
V
L
H
V
D
S
R
S
Y
-
Y
-----
G
G
N
------------
W
A
S
F
S
F
S
G
L
L
S
-------
W
L
K
E
Y
Q
E
---------
N
T
E
N
S
M
W
Q
E
Q
I
L
E
N
E
-
E
----------
A
I
P
L
S
S
K
D
K
T
I
Q
H
V
E
V
F
C
-
Y
A
S
Q
D
K
------
N
R
I
T
Y
S
Q
I
I
K
E
G
R
R
F
N
--------------
I
D
L
V
S
K
----
L
L
--------
Y
S
R
---
G
L
L
I
D
L
L
I
K
---
S
N
V
S
R
Y
A
E
F
-
K
-----
N
I
T
-------
R
I
L
--------
A
F
R
E
--------------------
G
T
V
E
Q
-
V
P
C
S
R
A
D
V
F
N
S
K
Q
L
-----------
T
M
V
E
K
R
M
-------------
L
M
K
F
L
-----
T
F
C
V
E
Y
E
E
H
-----
P
D
E
Y
R
--------
A
YEG---
T
T
F
S
E
Y
L
K
----
T
Q
K
--
L
T
P
N
L
Q
Y
F
V
LHSIAMTST
S
C
T
V
D
G
L
K
A
--
T
K
--
K
F
L
Q
C
L
G
---
R
YGNTPF
L
F
P
-
L
--
Y
G
Q
G
E
L
P
Q
C
F
C
R
-----
M
C
A
V
F
G
-
G
I
Y
C
L
R
-
H
S
-
V
Q
C
L
V
V
D
K
E
-----
S
R
K
C
K
A
V
I
D
Q
F
G
---
Q
R
I
--
I
----------------
S
---
K
H
------
F
I
I
E
D
S
-------------
Y
L
S
E
N
-------
T
C
S
R
-
V
Q
Y
R
Q
-----
I
S
R
A
V
----
L
-----
I
T
---
D
G
S
V
L
K
T
D
A
D
---------
Q
-
Q
-
V
S
I
L
T
V
-------
P
A
E
--
E
P
G
S
F
A
V
R
V
I
E
L
C
S
S
-----
T
-----
M
T
C
--
M
K
G
T
Y
L
-----------
V
H
L
T
C
M
-------
S
S
------
K
T
-------
A
R
E
D
L
E
R
V
V
Q
K
L
-
F
--
T
P
Y
T
-
E
I
E
E
---------
K
--
P
-----
R
-
L
L
W
---
A
L
Y
F
N
M
R
D
S
S
-------
D
I
S
R
D
C
Y
N
D
L
P
-------------
S
N
V
Y
V
C
S
G
P
------------------------------
D
S
G
L
G
N
D
N
A
--
V
K
Q
A
E
T
L
F
Q
-------------------
Q
I
----------
C
P
N
E
D
F
P
E
D
I
V
L
D
--------------------------------
4
PsiBlast_PDB
49.30
20%
53
- C10 -
3WEM
-
?
A:
[40-205]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
G
Y
GYQVK
N
A
K
V
D
--
N
S
T
G
K
S
L
T
A
L
L
Q
L
I
R
-----
N
-----
S
P
V
YG
P
D
I
Q
F
L
-----------
S
F
T
A
S
F
-------
E
E
------
D
D
T
L
R
I
R
-----
I
T
D
A
N
N
R
R
W
-
E
--
I
P
N
E
-
V
L
P
R
P
P
P
P
P
SPPP--------------------
Q
P
T
T
T
V
L
-------
S
H
P
H
S
D
L
V
F
T
L
-------------
F
H
T
T
P
F
G
F
T
------------------------------
I
Y
R
K
S
T
H
D
V
--
L
F
D
A
T
P
I
------------------------------------------------------------------------------
7
PsiBlast_PDB
48.54
30%
84
- C8 -
3QDN
-
?
A:
[229-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
Q
V
G
R
--
N
E
E
A
L
E
L
-------------
L
F
S
H
L
-----
R
K
D
L
T
A
A
E
G
-----
Q
T
R
K
T
--------
F
------
Q
E
I
L
A
A
L
G
----
T
G
D
A
L
A
S
K
Y
R
R
Q
L
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
48.45
20%
57
- C10 -
3W38
-
?
A:
[39-205]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
I
G
Y
GYQVKNA
K
V
D
--
N
S
T
G
K
S
L
T
A
L
L
Q
L
I
R
-----
N
-----
S
P
V
YG
P
D
I
Q
F
L
-----------
S
F
T
A
S
F
-------
E
E
------
D
D
T
L
R
I
R
-----
I
T
D
A
N
N
R
R
W
-
E
--
I
P
N
E
-
V
L
P
R
PPPPP-------------------------
P
T
T
T
V
L
-------
S
H
P
H
S
D
L
V
F
T
L
-------------
F
H
T
T
P
F
G
F
T
------------------------------
I
Y
R
K
S
T
H
D
V
--
L
F
D
A
T
P
I
------------------------------------------------------------------------------
3
PsiBlast_PDB
48.40
20%
62
- C10 -
3WEL
1
?
A:
[38-205]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
I
G
Y
G
Y
Q
V
K
N
A
K
V
D
--
N
S
T
G
K
S
L
T
A
L
L
Q
L
I
R
-----
N
-----
S
P
V
YG
P
D
I
Q
F
L
-----------
S
F
T
A
S
F
-------
E
E
------
D
D
T
L
R
I
R
-----
I
T
D
A
N
N
R
R
W
-
E
--
I
P
N
E
-
V
L
P
R
PPPPP-------------------------
P
T
T
T
V
L
-------
S
H
P
H
S
D
L
V
F
T
L
-------------
F
H
T
T
P
F
G
F
T
------------------------------
I
Y
R
K
S
T
H
D
V
--
L
F
D
A
T
P
I
------------------------------------------------------------------------------
5
PsiBlast_PDB
47.88
20%
59
- C10 -
3WEN
-
?
A:
[40-205]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
G
Y
GYQVK
N
A
K
V
D
--
N
S
T
G
K
S
L
T
A
L
L
Q
L
I
R
-----
N
-----
S
P
V
YG
P
D
I
Q
F
L
-----------
S
F
T
A
S
F
-------
E
E
------
D
D
T
L
R
I
R
-----
I
T
D
A
N
N
R
R
W
-
E
--
I
P
N
E
-
V
L
P
R
P
P
P
P
P
SPPP--------------------
Q
P
T
T
T
V
L
-------
S
H
P
H
S
D
L
V
F
T
L
-------------
F
H
T
T
P
F
G
F
T
------------------------------
I
Y
R
K
S
T
H
D
V
--
L
F
D
A
T
P
I
------------------------------------------------------------------------------
1
PsiBlast_PDB
47.71
20%
51
- C10 -
3W37
-
?
A:
[39-205]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
I
G
Y
G
Y
Q
V
K
N
A
K
V
D
--
N
S
T
G
K
S
L
T
A
L
L
Q
L
I
R
-----
N
-----
S
P
V
YG
P
D
I
Q
F
L
-----------
S
F
T
A
S
F
-------
E
E
------
D
D
T
L
R
I
R
-----
I
T
D
A
N
N
R
R
W
-
E
--
I
P
N
E
-
V
L
P
R
P
P
P
PP-------------------------
P
T
T
T
V
L
-------
S
H
P
H
S
D
L
V
F
T
L
-------------
F
H
T
T
P
F
G
F
T
------------------------------
I
Y
R
K
S
T
H
D
V
--
L
F
D
A
T
P
I
------------------------------------------------------------------------------
16
PsiBlast_PDB
44.93
27%
65
- C8 -
1NAR
-
?
A:
[109-210]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
I
I
Q
K
Y
S
D
D
S
-
G
--
N
L
I
D
-
G
I
D
I
---------
H
--
Y
-----
E
-
H
I
R
SDE
P
F
A
T
L
M
G
Q
L
I
-------
T
E
L
K
K
D
D
D
L
N
I
-------------
N
V
V
S
I
A
P
S
E
------------------------------
N
N
S
S
H
Y
Q
K
L
--
Y
N
A
K
K
D
Y
I
N
-------------------
W
V
D
Y
Q
F
S
NQ
Q
K
P
V
S
T
D
D
A
F
V
E
I
F
K
---------------------------------
21
PsiBlast_CBE
41.95
40%
77
- C10 -
4YEH
1
?
B:
[43-82]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
R
D
G
Y
K
S
-----
L
A
K
-------
T
I
F
--------
G
T
Y
G
--------------------
I
D
C
S
F
-----
D
T
E
Y
N
E
A
F
I
F
Y
E
N
F
C
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.90
38%
72
- C10 -
3V6N
5
?
A:
[43-85]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
S
F
V
R
D
G
Y
K
S
-----
L
A
K
-------
T
I
F
--------
G
T
Y
G
--------------------
I
D
C
S
F
-----
D
T
E
Y
N
E
A
F
I
F
Y
E
N
F
C
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
41.40
38%
73
* C10 *
4LL2
1
?
A:
[43-85]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
S
F
V
R
D
G
Y
K
S
-----
L
A
K
-------
T
I
F
--------
G
T
Y
G
--------------------
I
D
C
S
F
-----
D
T
E
Y
N
E
A
F
I
F
Y
E
N
F
C
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
40.71
40%
71
- C10 -
3S18
3
?
B:
[46-85]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
R
D
G
Y
K
S
-----
L
A
K
-------
T
I
F
--------
G
T
Y
G
--------------------
I
D
C
S
F
-----
D
T
E
Y
N
E
A
F
I
F
Y
E
N
F
C
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------