@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0348: (2016-03-14 )
MRRLVNDGYEAVEEMLAGYVAAQGKYVDFAENDKRVIVSKQMSEEPRVRIIVGGGSGHEPLFLGYVGKDFADAAVVGNINTSPSPEPCYNAVKAVDSGKGCLYMYGNYAGDVMNFDMGAEMAADDGIRVETVLVTDDIYSAEKVEDRRGVAGDLIVFKAAASAAAKGLDLDAVKQAAEKANANTFSMGVALSSSTLPVTGKAIFEMKEGEMEVGMGIHGEPGIKRTSIEPADKVVDQIMGYLIEEMKLTSDEEVHVLINGLGGLPVMDQYICYRRVDEILKEKGVHIHNPLVGNYATSMDMIGMSITLVRLDDELKDLLDTPCDTPYFKVD
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130......-.140-..--.--...-..150.......160.......170.......180.......190.......200.......210.......220..----.....230.......240.--------------------.------------------------.------------------------..----..--250.......260.......270.......280......-.290.--......300.......310-.-.--.....320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
R
L
V
N
D
G
Y
E
A
V
E
E
M
L
A
G
Y
V
AAQ
G
K
Y
V
DFAEND
K
R
V
I
V
S
K
QMSEEP
R
V
R
I
I
V
GGGSGHE
P
L
F
L
G
YVGKDFAD
A
A
V
VGNINTSPS
P
E
P
C
Y
N
A
V
K
A
VDSGK
G
C
L
Y
M
YGNYAGDVMNFDMGAEMAADDG
I
R
V
E
T
V
L
VTDDI-Y
S
A
--
E
K
--
V
--
E
D
R-RGVAG
D
L
I
V
F
KA
A
A
S
A
AAKGL
D
L
D
A
V
K
Q
A
A
E
KANAN
T
F
S
M
G
V
A
LSSSTLPVTG
K
A
I
F
E
MKEG
E
M
E
VGMGIHGEPGIK----RTSIE
P
A
D
K
V
V
D
Q
I
M
G
Y
L
I
--------------------
E
------------------------
E
------------------------MK----LT--SDE
E
V
H
V
L
I
NGLGGL
P
V
M
D
Q
Y
I
C
Y
R
R
V
D
E
I
L
K
EKG
V
H
IH-NPLVG--NYATS
M
D
MIG
M
S
I
T
L
V
RL
D
-
D
-
E
--
L
K
D
L
LDTPCDTPYFKVD-
35
HHSearch
99.31
37%
-95
- C5 -
1OI2
2
DHAK_ECOLI
A:
[20-364]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
-
L
T
L
H
Q
-
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
DS
L
Y
--
T
--
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
--------------------
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
E
Q
Q
T
K
------------------------
Q
P
----
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
A
L
N
W
--
50
Fugue
99.04
36%
-93
* C5 *
1OI2
2
DHAK_ECOLI
A:
[20-366]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
L
H
--
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
LY
T
--
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
--------------------
V
------------------------
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
E
Q
Q
T
K
Q
P
----
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
A
L
N
W
G
K
6
PsiBlast_PDB
96.81
34%
-94
- C5 -
1UOE
2
DHAK_ECOLI
A:
[20-360]
---------
Q
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
N
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
3
PsiBlast_PDB
96.72
34%
-93
- C5 -
1OI2
2
DHAK_ECOLI
A:
[20-360]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
5
PsiBlast_PDB
96.68
34%
-92
- C5 -
1UOD
2
DHAK_ECOLI
A:
[20-360]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
4
PsiBlast_PDB
96.49
34%
-94
- C5 -
1OI3
1
DHAK_ECOLI
A:
[20-360]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
25
PsiBlast_CBE
96.40
34%
-95
- C5 -
1OI2
2
DHAK_ECOLI
B:
[20-360]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
VNGSYHRTLRFWDYQQGSWQ
E
------------------------
E
------------------------
Q
Q
TKQP
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
10
PsiBlast_PDB
96.38
34%
-98
- C5 -
3PNO
-
DHAK_ECOLI
A:
[10-350]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
N
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
12
PsiBlast_PDB
96.31
34%
-97
- C5 -
3PNM
-
DHAK_ECOLI
A:
[10-350]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
A
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
T
-------
S
F
T
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
24
PsiBlast_CBE
96.08
34%
-96
- C5 -
1OI3
1
DHAK_ECOLI
B:
[20-360]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
VNGSYHRTLRFWDYQQGSWQ
E
------------------------
E
------------------------
Q
Q
TKQP
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
23
PsiBlast_CBE
96.03
34%
-94
- C5 -
1UOD
2
DHAK_ECOLI
B:
[20-360]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
VNGSYHRTLRFWDYQQGSWQ
E
------------------------
E
------------------------
Q
Q
TKQP
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
26
PsiBlast_CBE
96.01
34%
-94
- C5 -
1UOE
2
DHAK_ECOLI
B:
[20-360]
---------
Q
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
-----------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
N
T
V
D
E
M
F
D
T
L
L
VNGSYHRTLRFWDYQQGSWQ
E
------------------------
E
------------------------
Q
Q
TKQP
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
8
PsiBlast_PDB
95.94
34%
-92
- C5 -
3PNL
3
DHAK_ECOLI
A:
[3-351]
-
K
K
L
I
N
D
V
Q
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
T
V
P
A
A
G
K
P
S
F
T
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
29
PsiBlast_CBE
95.82
34%
-97
- C5 -
3PNQ
1
DHAK_ECOLI
D:
[11-351]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
N
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
-------------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
VNGSYHRTLRFWDYQQGSWQ
E
------------------------
E
------------------------
Q
Q
TKQP
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
34
HHSearch
95.69
38%
-96
- C5 -
3CT4
1
DHAK_LACLA
A:
[4-331]
-
E
K
I
I
N
Q
P
Q
D
V
V
S
E
M
L
D
G
L
T
Y
A
Y
G
D
L
I
E
K
V
P
-
D
F
E
I
I
Q
R
K
S
P
K
-
S
G
K
V
A
L
V
S
G
G
G
S
G
H
E
P
A
H
A
G
F
V
G
E
G
M
L
S
A
A
V
C
G
A
I
F
T
S
P
T
P
D
Q
I
Y
E
A
I
K
S
A
D
E
G
A
G
V
L
L
I
I
K
N
Y
L
G
D
V
M
N
F
E
M
A
R
E
M
A
E
M
E
E
I
K
V
E
Q
I
I
V
D
D
D
I
-
A
V
E
NS
L
Y
--
T
--
Q
G
R
-
R
G
V
A
G
T
V
L
V
H
K
I
L
G
A
A
A
H
Q
E
A
S
L
D
E
I
K
D
L
A
D
K
V
V
K
N
I
K
T
I
G
L
A
L
S
A
A
T
V
P
----------
D
N
E
I
E
Y
G
V
G
I
H
S
E
P
G
Y
R
----
R
E
K
M
K
T
S
Y
E
L
A
T
E
L
V
G
K
L
K
--------------------
E
------------------------
E
------------------------
F
K
----
F
E
--
A
G
Q
K
Y
G
I
L
V
N
G
M
G
A
T
P
L
M
E
Q
F
I
F
M
N
D
V
A
K
L
L
T
E
E
N
I
E
I
L
-
F
K
K
V
G
--
N
Y
M
T
S
I
D
M
A
G
L
S
L
T
M
I
K
L
E
D
D
-
Q
--
W
L
K
N
L
N
E
D
V
K
T
I
S
W
----
11
PsiBlast_PDB
95.64
34%
-99
- C5 -
3PNQ
-
DHAK_ECOLI
A:
[11-351]
---------
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
N
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
-------------
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
2
PsiBlast_PDB
95.40
34%
-92
- C5 -
4LRX
1
DHAK_ECOLI
A:
[1-350]
M
K
K
L
I
N
D
V
Q
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
T
V
P
A
A
G
K
P
S
F
T
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
7
PsiBlast_PDB
95.38
34%
-96
- C5 -
3PNK
1
DHAK_ECOLI
A:
[3-351]
-
K
K
L
I
N
D
V
Q
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
T
V
P
A
A
G
K
P
S
F
T
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
27
PsiBlast_CBE
95.19
34%
-96
- C5 -
3PNK
1
DHAK_ECOLI
B:
[3-351]
-
K
K
L
I
N
D
V
Q
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
T
V
P
A
A
G
K
P
S
F
T
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
VNGSYHRTLRFWDYQQGSWQ
E
------------------------
E
------------------------
Q
Q
TKQP
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
9
PsiBlast_PDB
95.14
34%
-93
- C5 -
4LRY
1
DHAK_ECOLI
A:
[1-350]
M
K
K
L
I
N
D
V
Q
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
L
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
T
V
P
A
A
G
K
P
S
F
T
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
V
N
G
S
Y
H
R
T
L
R
F
W
DYQQG
S
W
Q
E
------------------------
E
------------------------
Q
Q
T
K
Q
P
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
22
PsiBlast_CBE
95.08
34%
-93
- C5 -
4LRX
1
DHAK_ECOLI
B:
[1-350]
M
K
K
L
I
N
D
V
Q
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
T
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
T
V
P
A
A
G
K
P
S
F
T
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
VNGSYHRTLRFWDYQQGSWQ
E
------------------------
E
------------------------
Q
Q
TKQP
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
20
PsiBlast_CBE
94.84
38%
-90
- C5 -
3CT4
1
DHAK_LACLA
C:
[4-322]
-
E
K
I
I
N
Q
P
Q
D
V
V
S
E
M
L
D
G
L
T
Y
A
Y
G
D
L
I
E
K
V
P
D
F
E
--
I
I
Q
R
K
S
P
K
S
G
K
V
A
L
V
S
G
G
G
S
G
H
E
P
A
H
A
G
F
V
G
E
G
M
L
S
A
A
V
C
G
A
I
F
T
S
P
T
P
D
Q
I
Y
E
A
I
K
S
A
D
E
G
A
G
V
L
L
I
I
K
N
Y
L
G
D
V
M
N
F
E
M
A
R
E
M
A
E
M
E
E
I
K
V
E
Q
I
I
V
D
D
D
I
-
A
V
E
--
N
S
--
L
YT
Q
G
R
-
R
G
V
A
G
T
V
L
V
H
K
I
L
G
A
A
A
H
Q
E
A
S
L
D
E
I
K
D
L
A
D
K
V
V
K
N
I
K
T
I
G
L
A
L
S
A
A
T
V
P
----------
D
N
E
I
E
Y
G
V
G
I
H
S
E
P
G
Y
R
----
R
E
K
M
K
T
S
Y
E
L
A
T
E
L
V
G
K
L
K
--------------------
E
------------------------
E
------------------------
F
K
----
F
E
--
A
G
Q
K
Y
G
I
L
V
N
G
M
G
A
T
P
L
M
E
Q
F
I
F
M
N
D
V
A
K
L
L
T
E
E
N
I
E
I
L
-
F
K
K
V
G
--
N
Y
M
T
S
I
D
M
A
G
L
S
L
T
M
I
K
L
E
-
D
-
D
QW
L
K
N
L
--------------
28
PsiBlast_CBE
94.83
34%
-92
- C5 -
4LRY
1
DHAK_ECOLI
B:
[1-350]
M
K
K
L
I
N
D
V
Q
D
V
L
D
E
Q
L
A
G
L
A
K
A
H
P
S
L
T
--
L
H
Q
D
P
V
Y
V
T
R
A
D
A
P
V
A
G
K
V
A
L
L
S
G
G
G
S
G
H
E
P
M
H
C
G
Y
I
G
Q
G
M
L
S
G
A
C
P
G
E
I
F
L
S
P
T
P
D
K
I
F
E
C
A
M
Q
V
D
G
G
E
G
V
L
L
I
I
K
N
Y
T
G
D
I
L
N
F
E
T
A
T
E
L
L
H
D
S
G
V
K
V
T
T
V
V
I
D
D
D
V
-
A
V
K
--
D
S
--
L
YT
A
G
R
-
R
G
V
A
N
T
V
L
I
E
K
L
V
G
A
A
A
E
R
G
D
S
L
D
A
C
A
E
L
G
R
K
L
N
N
Q
G
H
S
I
G
I
A
L
G
A
C
T
V
P
A
A
G
K
P
S
F
T
L
A
D
N
E
M
E
F
G
V
G
I
H
G
E
P
G
I
D
----
R
R
P
F
S
S
L
D
Q
T
V
D
E
M
F
D
T
L
L
VNGSYHRTLRFWDYQQGSWQ
E
------------------------
E
------------------------
Q
Q
TKQP
L
Q
--
S
G
D
R
V
I
A
L
V
N
N
L
G
A
T
P
L
S
E
L
Y
G
V
Y
N
R
L
T
T
R
C
Q
Q
A
G
L
T
I
E
-
R
N
L
I
G
--
A
Y
C
T
S
L
D
M
T
G
F
S
I
T
L
L
K
V
D
-
D
-
E
--
T
L
A
L
W
D
A
P
V
H
T
P
------
21
PsiBlast_CBE
94.78
38%
-89
- C5 -
3CT4
1
DHAK_LACLA
B:
[4-322]
-
E
K
I
I
N
Q
P
Q
D
V
V
S
E
M
L
D
G
L
T
Y
A
Y
G
D
L
I
E
K
V
P
D
F
E
--
I
I
Q
R
K
S
P
K
S
G
K
V
A
L
V
S
G
G
G
S
G
H
E
P
A
H
A
G
F
V
G
E
G
M
L
S
A
A
V
C
G
A
I
F
T
S
P
T
P
D
Q
I
Y
E
A
I
K
S
A
D
E
G
A
G
V
L
L
I
I
K
N
Y
L
G
D
V
M
N
F
E
M
A
R
E
M
A
E
M
E
E
I
K
V
E
Q
I
I
V
D
D
D
I
-
A
V
E
--
N
S
--
L
YT
Q
G
R
-
R
G
V
A
G
T
V
L
V
H
K
I
L
G
A
A
A
H
Q
E
A
S
L
D
E
I
K
D
L
A
D
K
V
V
K
N
I
K
T
I
G
L
A
L
S
A
A
T
V
P
----------
D
N
E
I
E
Y
G
V
G
I
H
S
E
P
G
Y
R
----
R
E
K
M
K
T
S
Y
E
L
A
T
E
L
V
G
K
L
K
--------------------
E
------------------------
E
------------------------
F
K
----
F
E
--
A
G
Q
K
Y
G
I
L
V
N
G
M
G
A
T
P
L
M
E
Q
F
I
F
M
N
D
V
A
K
L
L
T
E
E
N
I
E
I
L
-
F
K
K
V
G
--
N
Y
M
T
S
I
D
M
A
G
L
S
L
T
M
I
K
L
E
-
D
-
D
QW
L
K
N
L
--------------
1
PsiBlast_PDB
94.68
38%
-90
- C5 -
3CT4
1
DHAK_LACLA
A:
[4-322]
-
E
K
I
I
N
Q
P
Q
D
V
V
S
E
M
L
D
G
L
T
Y
A
Y
G
D
L
I
E
K
V
P
D
F
E
--
I
I
Q
R
K
S
P
K
S
G
K
V
A
L
V
S
G
G
G
S
G
H
E
P
A
H
A
G
F
V
G
E
G
M
L
S
A
A
V
C
G
A
I
F
T
S
P
T
P
D
Q
I
Y
E
A
I
K
S
A
D
E
G
A
G
V
L
L
I
I
K
N
Y
L
G
D
V
M
N
F
E
M
A
R
E
M
A
E
M
E
E
I
K
V
E
Q
I
I
V
D
D
D
I
-
A
V
E
--
N
S
--
L
YT
Q
G
R
-
R
G
V
A
G
T
V
L
V
H
K
I
L
G
A
A
A
H
Q
E
A
S
L
D
E
I
K
D
L
A
D
K
V
V
K
N
I
K
T
I
G
L
A
L
S
A
A
T
V
P
----------
D
N
E
I
E
Y
G
V
G
I
H
S
E
P
G
Y
R
----
R
E
K
M
K
T
S
Y
E
L
A
T
E
L
V
G
K
L
K
--------------------
E
------------------------
E
------------------------
F
K
----
F
E
--
A
G
Q
K
Y
G
I
L
V
N
G
M
G
A
T
P
L
M
E
Q
F
I
F
M
N
D
V
A
K
L
L
T
E
E
N
I
E
I
L
-
F
K
K
V
G
--
N
Y
M
T
S
I
D
M
A
G
L
S
L
T
M
I
K
L
E
-
D
-
D
Q
W
L
K
N
L
--------------
15
PsiBlast_PDB
90.48
32%
-95
- C5 -
2IU6
1
DHAQ_LACLA
A:
[5-323]
-----
N
S
T
N
E
I
P
E
E
M
L
K
G
I
D
L
T
Y
P
Q
L
T
Y
L
P
E
T
G
---
I
L
Y
D
N
T
Y
N
E
K
T
V
P
I
I
S
G
G
G
S
G
H
E
P
A
H
V
G
Y
V
G
S
G
M
L
A
A
A
V
T
G
P
L
F
I
P
P
K
S
K
N
I
L
K
A
I
R
Q
V
N
S
G
K
G
V
F
V
I
I
K
N
F
E
A
D
L
K
E
F
N
E
A
I
K
E
A
R
T
E
G
I
D
V
R
Y
I
V
S
H
D
D
I
S
V
N
A
--
Y
N
--
F
--
H
K
R
H
R
G
V
A
G
T
I
L
L
H
K
I
L
G
A
F
A
K
E
G
G
S
I
D
E
I
E
Q
L
A
L
S
L
S
P
E
I
Y
T
L
G
V
A
L
------------------
E
V
S
F
G
I
G
I
H
G
E
P
G
Y
R
----
V
E
K
F
E
G
S
E
R
I
A
I
E
L
V
N
K
L
K
--------------------
A
------------------------
E
------------------------
I
N
----
W
Q
KK
A
N
K
N
Y
I
L
L
V
N
G
L
G
S
T
T
L
M
E
L
Y
S
F
Q
Y
D
V
M
R
L
L
E
L
E
G
L
S
V
K
-
F
C
K
V
G
--
N
L
M
T
S
C
D
M
S
G
I
S
L
T
L
C
S
V
K
-
D
P
K
--
W
L
D
Y
L
N
V
P
T
---------
32
PsiBlast_CBE
89.35
32%
-93
- C5 -
2IU6
1
DHAQ_LACLA
B:
[5-323]
-----
N
S
T
N
E
I
P
E
E
M
L
K
G
I
D
L
T
Y
P
Q
L
T
Y
L
P
E
T
G
---
I
L
Y
D
N
T
Y
N
E
K
T
V
P
I
I
S
G
G
G
S
G
H
E
P
A
H
V
G
Y
V
G
S
G
M
L
A
A
A
V
T
G
P
L
F
I
P
P
K
S
K
N
I
L
K
A
I
R
Q
V
N
S
G
K
G
V
F
V
I
I
K
N
F
E
A
D
L
K
E
F
N
E
A
I
K
E
A
R
T
E
G
I
D
V
R
Y
I
V
S
H
D
D
I
S
V
N
A
--
Y
N
--
F
--
H
K
R
H
R
G
V
A
G
T
I
L
L
H
K
I
L
G
A
F
A
K
E
G
G
S
I
D
E
I
E
Q
L
A
L
S
L
S
P
E
I
Y
T
L
G
V
A
L
A
P
V
--------------
D
E
V
S
F
G
I
G
I
H
G
E
P
G
Y
R
----
V
E
K
F
E
G
S
E
R
I
A
I
E
L
V
N
K
L
K
--------------------
A
------------------------
E
------------------------
I
N
----
W
Q
KK
A
N
K
N
Y
I
L
L
V
N
G
L
G
S
T
T
L
M
E
L
Y
S
F
Q
Y
D
V
M
R
L
L
E
L
E
G
L
S
V
K
-
F
C
K
V
G
--
N
L
M
T
S
C
D
M
S
G
I
S
L
T
L
C
S
V
K
-
D
P
K
--
W
L
D
Y
L
N
V
P
T
---------
14
PsiBlast_PDB
87.72
36%
-89
- C5 -
1UN9
1
DHAK_CITFR
A:
[39-340]
----------------------------------
R
I
V
V
R
R
D
L
N
K
N
-
N
V
A
V
I
S
G
G
G
S
G
H
E
P
A
H
V
G
F
I
G
K
G
M
L
T
A
A
V
C
G
D
V
F
A
S
P
S
V
D
A
V
L
T
A
I
Q
A
V
T
G
E
A
G
C
L
L
I
V
K
N
Y
T
G
D
R
L
N
F
G
L
A
A
E
K
A
R
R
L
G
Y
N
V
E
M
L
I
V
G
D
D
I
--
S
L
--
P
D
--
N
--
K
H
P
-
R
G
I
A
G
T
I
L
V
H
K
I
A
G
Y
F
A
E
R
G
Y
N
L
A
T
V
L
R
E
A
Q
Y
A
A
S
N
T
F
S
L
G
V
A
L
S
S
C
H
L
P
Q
E
T
D
A
A
P
R
H
H
P
G
H
A
E
L
G
M
G
I
H
G
E
P
G
A
S
VIDT
Q
N
S
A
Q
V
V
N
L
M
V
D
K
L
L
A
A
L
P
--------------------
E
------------------------
T
------------------------
G
R
----
L
A
--------
V
M
I
N
N
L
G
G
V
S
V
A
E
M
A
I
I
T
R
E
----
L
A
S
S
P
L
H
S
R
I
D
W
L
I
G
PA
S
L
V
T
A
L
D
M
K
G
F
S
L
T
A
I
V
L
E
-
E
-
S
--
I
E
K
A
L
L
T
E
V
E
T
S
N
W
----
31
PsiBlast_CBE
87.71
36%
-89
- C5 -
1UN9
1
DHAK_CITFR
B:
[39-340]
----------------------------------
R
I
V
V
R
R
D
L
N
K
N
-
N
V
A
V
I
S
G
G
G
S
G
H
E
P
A
H
V
G
F
I
G
K
G
M
L
T
A
A
V
C
G
D
V
F
A
S
P
S
V
D
A
V
L
T
A
I
Q
A
V
T
G
E
A
G
C
L
L
I
V
K
N
Y
T
G
D
R
L
N
F
G
L
A
A
E
K
A
R
R
L
G
Y
N
V
E
M
L
I
V
G
D
D
I
--
S
L
--
P
D
--
N
--
K
H
P
-
R
G
I
A
G
T
I
L
V
H
K
I
A
G
Y
F
A
E
R
G
Y
N
L
A
T
V
L
R
E
A
Q
Y
A
A
S
N
T
F
S
L
G
V
A
L
S
S
C
H
L
P
Q
E
T
D
A
A
P
R
H
H
P
G
H
A
E
L
G
M
G
I
H
G
E
P
G
A
S
VIDT
Q
N
S
A
Q
V
V
N
L
M
V
D
K
L
L
A
A
L
P
--------------------
E
------------------------
T
------------------------
G
R
----
L
A
--------
V
M
I
N
N
L
G
G
V
S
V
A
E
M
A
I
I
T
R
E
----
L
A
S
S
P
L
H
S
R
I
D
W
L
I
G
PA
S
L
V
T
A
L
D
M
K
G
F
S
L
T
A
I
V
L
E
-
E
-
S
--
I
E
K
A
L
L
T
E
V
E
T
S
N
W
----