@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0386: (2016-03-15 )
VTEKTIRLTTAQALVKFLNQQYIEVDDEMAPFVDGIFTVFGHGNVVGIGQALEEDPGHLNVYQGKNEQGMAHAAIAYAKQKNRKRIYACSASAGPGSANLITAASTALANNLPVLFLPADTFATRQPDPVLQQLEHESSAAITTNDGFQAVSRYFDRVQRPEQLMSALIRAFEVMTNPASAGPATICIAQDTEGEAFDYPVEFFQKRIHYLNRQIPTKRELTEAARLIQASKTPVIIVGGGARYSDAREELIALSEQSNIPLVETHAGKSTVEFDFKNNLGGTGILGTLAANKAIRDADLVIGIGTRYTDFTTSSKTAFGPATKFININVSRMQTYKLDAFQVVGDAKATLAELAPLLKGYQTQFGDRIAVYKAEWLAERTRLQNTKFNREAFTPEIKDQFDQATLNEYADSLQTEFTQTEALITINDTVAPDSIVVCSAGSLPGDLQRLWNPAVPNTYHLEYGYSCMGYEINGALGAKMAAANNQEVYSIVGDGSFCMSHSELLTSLQYGKKINIMLFDNSGFGCINNLQMANGSDSFFCEFRDSDNQIMQVDYAKIAEGYGAKVYRANTKEDLISALEDAKKQTKTTLIDMKVLPKTMSEGYLNWWNVGVSEVSNKESIKQAYEEKQTNLKNARLY
Atome Classification :
(20 SA)
.........10........20........30........40--.--.......50........60........70........80-........90........100.......110.......120...-....130.......140.......-----150.....----..160.......170.......180.......190.......200..-.-....210-.--..-----.....-------.220.......---230.......-240-..-.....250.......260.......270.......280-.-..----..-..290.......300.......310.......320--------...---------.....330...---....-340..--.--.--....350.......360.......370.......380.......390.......400.......410...----....420.......430---..---.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530-.......540--.........550.......560.......570.......580--..--.----.....590.......600.......610.......620.......630......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VTE
K
T
I
R
L
T
T
A
Q
A
L
V
K
F
L
N
Q
Q
Y
IEVDD
E
M
A
P
F
V
D
G
I
F
T
V
FG--H--G
N
V
V
GI
G
Q
A
L
EEDPGH
L
N
V
YQGKNEQG
M
A
H
A
A
I
A
Y
A
KQK-NR
K
R
I
Y
A
C
SASAGPGSA
N
L
I
T
A
A
S
T
A
LANNL
P
V
L
F
LPADTFATR-QP
D
P
V
L
Q
Q
L
EHESS
A
A
I
TTN
D
G
F
Q
-----
A
V
S
R
Y
F
D
R----VQ
R
P
E
Q
L
M
S
A
L
I
R
A
F
E
V
MTNPASAG
P
A
T
I
C
I
A
QDTEGEAFDY
P
V
E
F
F
-
Q
-
K
R
I
H
Y
---
L
--NR-----QIP
T
K
-------
R
E
L
T
E
A
A
R
L
I
Q---ASKT
P
V
I
I
VG-GGA-RY-
S
D
A
R
E
E
L
I
A
LSEQSNI
P
L
V
E
THAGK
S
T
V
E
F
D
FKNNLGG-T-G
I
----
L
G
-
T
L
AANKAIRDA
D
L
V
I
G
IGT
R
Y
T
D
FTTSSKTAFGP---------A
T
K
---------
F
I
N
I
N
V
S
R
M
Q
T
---
Y
KL
D
-
A
-
F
Q
V
--V--G--D
A
K
A
T
L
A
E
L
A
P
L
L
K
G
Y
Q
T
QFG
D
R
I
A
V
Y
K
A
E
W
L
A
E
R
T
RLQNTKFNREAF
T
P
E
I
K
D
Q
F
D
Q
A
T
L
N
E
Y
A
D
S
L
Q
T
----
E
FTQ
T
E
A
L
I
T
INDTV-----AP---D
S
I
V
V
CSAGSL
P
G
D
L
Q
R
LWNPAVP
N
T
Y
H
L
E
YG
Y
S
C
M
G
Y
E
INGALGA
K
M
AAANN
Q
E
V
Y
S
I
VGD
G
S
F
C
M
S
H
S
E
L
L
T
S
L
QYG
K
K
I
N
I
M
L
FDNSGFGCINNLQM-ANGSD
S
F
F
----
C
E
FRDSDN
Q
I
M
Q
V
D
Y
A
K
I
A
EGYG
A
K
V
Y
RAN
T
K
E
D
L
I
S
A
L
E
D
---
A
K
--
K
----QTK
T
T
L
I
D
M
KVL
P
K
T
M
S
EG
Y
L
N
W
W
NV
G
V
S
EVS
N
K
E
S
I
K
Q
A
Y
E
E
K
QTNLKNARLY
28
HHSearch
87.43
23%
-74
- C5 -
3EYA
11
POXB_ECOLI
A:
[2-535]
------
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
----------
V
K
R
I
W
G
V
T
G
--
D
---
S
L
N
G
L
S
D
S
L
N
R
M
-
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
-
G
--
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
-
I
G
S
G
Y
F
Q
E
--------
T
H
P
Q
E
L
F
R
-----
E
C
S
H
Y
C
E
L
----
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
--
N
R
G
V
S
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
G
A
T
M
H
-
W
-
Y
H
A
-
P
---
Q
--
P
V
-----
V
T
P
E
E
-------
E
E
L
R
K
L
A
Q
L
L
R
---
Y
S
S
N
I
A
L
M
C
G
-
S
G
C
-
A
G
---
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
-
T
-
G
L
----
I
G
-
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
-----
Y
P
T
---------
D
A
K
---------
I
I
Q
I
D
I
N
P
A
S
I
---
G
A
H
S
K
V
D
M
A
L
--
V
--
G
--
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
-
A
D
R
K
F
-----
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
-------------------
D
D
L
A
K
P
S
E
K
----
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
-----
A
D
---
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
-
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
----------------------
G
T
E
--
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
---
A
F
--
S
----
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
-----------------------------------
23
HHSearch
87.04
23%
-65
- C5 -
1T9B
9
ILVB_YEAST
A:
[77-642]
--
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
----------
V
D
T
V
F
G
Y
P
G
--
G
---
A
I
L
P
V
Y
D
A
I
H
N
S
-
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
-
I
G
T
D
A
F
Q
E
--------
A
D
V
V
G
I
S
R
-----
S
C
T
K
W
N
V
M
----
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
-
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
-------------------------
F
V
M
-------
Q
S
I
N
K
A
A
D
L
I
N
---
L
A
K
K
P
V
L
Y
V
G
-
A
G
I
-
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
-
L
-
G
M
----
H
G
-
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
---------
I
I
H
F
E
V
S
P
K
N
I
---
N
K
V
V
Q
T
Q
I
A
V
--
E
--
G
--
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
R
---------
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
-
Y
--------------
A
Y
M
--
E
E
T
P
G
S
----
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
-----
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
-
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
-----
L
F
Y
E
----
H
R
Y
S
H
T
H
--
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
---
F
V
--
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
------------------------------------
35
HHSearch
86.79
23%
-67
- C5 -
1V5E
5
?
A:
[2-541]
-----
N
K
I
N
I
G
L
A
V
M
K
I
L
E
S
W
G
----------
A
D
T
I
Y
G
I
P
S
--
G
---
T
L
S
S
L
M
D
A
M
G
E
E
E
N
N
V
K
F
L
Q
V
K
H
E
E
V
G
A
M
A
A
V
M
Q
S
K
F
G
-
G
--
N
L
G
V
T
V
G
S
G
G
P
G
A
S
H
L
I
N
G
L
Y
D
A
A
M
D
N
I
P
V
V
A
I
L
G
S
R
P
Q
R
E
-
L
N
M
D
A
F
Q
E
--------
L
N
Q
N
P
M
Y
D
-----
H
I
A
V
Y
N
R
R
----
V
A
Y
A
E
Q
L
P
K
L
V
D
E
A
A
R
M
A
I
--
A
K
R
G
V
A
V
L
E
V
P
G
D
F
A
K
V
E
I
D
N
D
Q
W
Y
S
S
A
-
N
S
L
R
K
---
Y
--
A
P
-----
I
A
P
A
A
-------
Q
D
I
D
A
A
V
E
L
L
N
---
N
S
K
R
P
V
I
Y
A
G
-
I
G
T
-
M
G
-
H
--
G
P
A
V
Q
E
L
A
R
K
I
K
A
P
V
I
T
T
G
K
N
F
E
T
F
E
W
D
F
E
A
L
T
G
S
-
T
-
Y
R
----
V
G
-
W
K
P
A
N
E
T
I
L
E
A
D
T
V
L
F
A
G
S
N
F
P
F
S
E
V
E
G
T
--
F
R
N
---------
V
D
N
---------
F
I
Q
I
D
I
D
P
A
M
L
---
G
K
R
H
H
A
D
V
A
I
--
L
--
G
--
D
A
A
L
A
I
D
E
I
L
N
K
V
D
A
V
-
E
E
S
A
W
W
-----
T
A
N
L
K
N
I
A
N
W
R
E
Y
I
-------------------
N
M
L
E
T
K
E
E
G
----
D
L
Q
F
Y
Q
V
Y
N
A
I
N
N
H
A
-----
D
E
---
D
A
I
Y
S
I
D
V
G
N
S
T
Q
T
S
I
R
H
L
H
M
T
P
K
N
M
W
R
T
S
P
L
F
A
T
M
G
I
A
I
P
G
G
L
G
A
K
N
T
Y
P
-
D
R
Q
V
W
N
I
I
G
D
G
A
F
S
M
T
Y
P
D
V
V
T
N
V
R
Y
N
M
P
V
I
N
V
V
F
S
N
T
E
Y
A
F
I
K
N
K
Y
E
-----
D
T
N
K
-----
N
L
F
G
V
D
--
F
T
D
V
D
Y
A
K
I
A
E
A
Q
G
A
K
G
F
T
V
S
R
I
E
D
M
D
R
V
M
A
E
---
A
V
--
A
A
N
K
-
A
G
H
T
V
V
I
D
C
K
I
T
Q
D
R
---------------------------------------
19
PsiBlast_PDB
85.89
24%
-64
- C5 -
2DJI
5
?
A:
[18-537]
----------------------------------
G
A
D
T
I
Y
G
I
P
S
--
G
T
L
S
S
L
M
D
A
M
G
E
E
E
N
N
V
K
F
L
Q
V
K
H
E
E
V
G
A
M
A
A
V
M
--
Q
S
K
-
F
G
G
N
L
G
V
T
V
G
S
G
G
P
G
A
S
H
L
I
N
G
L
Y
D
A
A
M
D
N
I
P
V
V
A
I
----
L
G
S
R
-
P
Q
----
R
E
L
N
M
D
A
F
Q
E
L
N
Q
N
P
M
Y
D
-----
H
I
A
V
Y
N
R
R
----
V
A
Y
A
E
Q
L
P
K
L
V
D
E
A
A
R
M
A
I
--
A
K
R
G
V
A
V
L
E
V
P
G
D
F
A
K
V
E
I
D
N
D
Q
W
Y
S
-
S
A
N
S
L
R
K
---
Y
--
A
P
-----
I
A
P
A
A
-------
Q
D
I
D
A
A
V
E
L
L
N
---
N
S
K
R
P
V
I
Y
A
G
I
G
T
M
-
G
H
-
G
P
A
V
Q
E
L
---
A
R
K
I
K
A
P
V
I
T
T
G
K
N
F
E
T
F
E
W
D
F
E
A
L
T
G
S
-
T
-
Y
R
----
V
G
-
W
K
P
A
N
E
T
I
L
E
A
D
T
V
L
F
A
G
S
N
F
P
-
F
S
E
V
E
G
T
-
F
R
N
---------
V
D
N
---------
F
I
Q
I
D
I
D
P
A
M
L
---
G
K
R
H
-
H
-
A
D
V
A
I
L
--
G
--
D
A
A
L
A
I
D
E
I
L
N
K
V
D
A
V
E
E
S
---------
A
W
W
T
A
N
L
K
N
I
A
N
W
R
--------------------
E
Y
I
N
M
L
E
T
KEEG
D
L
Q
F
Y
Q
V
Y
N
A
I
N
N
H
A
-----
D
E
---
D
A
I
Y
S
I
D
V
G
N
S
T
Q
T
S
I
R
H
L
H
M
T
P
K
N
M
W
R
T
S
P
L
F
A
T
M
G
I
A
I
P
G
G
L
G
A
K
N
T
Y
P
D
R
Q
-
V
W
N
I
I
G
D
G
A
F
S
M
T
Y
P
D
V
V
T
N
V
R
Y
N
M
P
V
I
N
V
V
F
S
N
T
E
Y
A
F
I
K
N
K
Y
E
-
D
T
N
K
N
L
F
G
----
V
D
F
T
D
-------
V
D
Y
A
K
I
A
E
A
Q
G
A
K
G
F
T
V
S
R
I
E
D
M
D
R
V
M
A
E
A
V
A
A
N
--
K
----
A
G
H
T
V
V
I
D
C
K
I
-------------------------------------------
20
PsiBlast_PDB
85.68
24%
-65
- C5 -
1V5F
7
?
A:
[17-536]
----------------------------------
G
A
D
T
I
Y
G
I
P
S
--
G
T
L
S
S
L
M
D
A
M
G
E
E
E
N
N
V
K
F
L
Q
V
K
H
E
E
V
G
A
M
A
A
V
M
--
Q
S
K
-
F
G
G
N
L
G
V
T
V
G
S
G
G
P
G
A
S
H
L
I
N
G
L
Y
D
A
A
M
D
N
I
P
V
V
A
I
----
L
G
S
R
-
P
Q
----
R
E
L
N
M
D
A
F
Q
E
L
N
Q
N
P
M
Y
D
-----
H
I
A
V
Y
N
R
R
----
V
A
Y
A
E
Q
L
P
K
L
V
D
E
A
A
R
M
A
I
--
A
K
R
G
V
A
V
L
E
V
P
G
D
F
A
K
V
E
I
D
N
D
Q
W
Y
S
-
S
A
N
S
L
R
K
---
Y
--
A
P
-----
I
A
P
A
A
-------
Q
D
I
D
A
A
V
E
L
L
N
---
N
S
K
R
P
V
I
Y
A
G
I
G
T
M
-
G
H
-
G
P
A
V
Q
E
L
---
A
R
K
I
K
A
P
V
I
T
T
G
K
N
F
E
T
F
E
W
D
F
E
A
L
T
G
S
-
T
-
Y
R
----
V
G
-
W
K
P
A
N
E
T
I
L
E
A
D
T
V
L
F
A
G
S
N
F
P
-
F
S
E
V
E
G
T
-
F
R
N
---------
V
D
N
---------
F
I
Q
I
D
I
D
P
A
M
L
---
G
K
R
H
-
H
-
A
D
V
A
I
L
--
G
--
D
A
A
L
A
I
D
E
I
L
N
K
V
D
A
V
E
E
S
---------
A
W
W
T
A
N
L
K
N
I
A
N
W
R
--------------------
E
Y
I
N
M
L
E
T
KEEG
D
L
Q
F
Y
Q
V
Y
N
A
I
N
N
H
A
-----
D
E
---
D
A
I
Y
S
I
D
V
G
N
S
T
Q
T
S
I
R
H
L
H
M
T
P
K
N
M
W
R
T
S
P
L
F
A
T
M
G
I
A
I
P
G
G
L
G
A
K
N
T
Y
P
D
R
Q
-
V
W
N
I
I
G
D
G
A
F
S
M
T
Y
P
D
V
V
T
N
V
R
Y
N
M
P
V
I
N
V
V
F
S
N
T
E
Y
A
F
I
K
N
K
Y
E
-
D
T
N
K
N
L
F
G
----
V
D
F
T
D
-------
V
D
Y
A
K
I
A
E
A
Q
G
A
K
G
F
T
V
S
R
I
E
D
M
D
R
V
M
A
E
A
V
A
A
N
--
K
----
A
G
H
T
V
V
I
D
C
K
I
-------------------------------------------
18
PsiBlast_PDB
85.01
24%
-65
- C5 -
1V5E
5
?
A:
[18-537]
----------------------------------
G
A
D
T
I
Y
G
I
P
S
--
G
T
L
S
S
L
M
D
A
M
G
E
E
E
N
N
V
K
F
L
Q
V
K
H
E
E
V
G
A
M
A
A
V
M
--
Q
S
K
-
F
G
G
N
L
G
V
T
V
G
S
G
G
P
G
A
S
H
L
I
N
G
L
Y
D
A
A
M
D
N
I
P
V
V
A
I
----
L
G
S
R
-
P
Q
----
R
E
L
N
M
D
A
F
Q
E
L
N
Q
N
P
M
Y
D
-----
H
I
A
V
Y
N
R
R
----
V
A
Y
A
E
Q
L
P
K
L
V
D
E
A
A
R
M
A
I
--
A
K
R
G
V
A
V
L
E
V
P
G
D
F
A
K
V
E
I
D
N
D
Q
W
Y
S
-
S
A
N
S
L
R
K
---
Y
--
A
P
-----
I
A
P
A
A
-------
Q
D
I
D
A
A
V
E
L
L
N
---
N
S
K
R
P
V
I
Y
A
G
I
G
T
M
-
G
H
-
G
P
A
V
Q
E
L
---
A
R
K
I
K
A
P
V
I
T
T
G
K
N
F
E
T
F
E
W
D
F
E
A
L
T
G
S
-
T
-
Y
R
----
V
G
-
W
K
P
A
N
E
T
I
L
E
A
D
T
V
L
F
A
G
S
N
F
P
-
F
S
E
V
E
G
T
-
F
R
N
---------
V
D
N
---------
F
I
Q
I
D
I
D
P
A
M
L
---
G
K
R
H
-
H
-
A
D
V
A
I
L
--
G
--
D
A
A
L
A
I
D
E
I
L
N
K
V
D
A
V
E
E
S
---------
A
W
W
T
A
N
L
K
N
I
A
N
W
R
--------------------
E
Y
I
N
M
L
E
T
KEEG
D
L
Q
F
Y
Q
V
Y
N
A
I
N
N
H
A
-----
D
E
---
D
A
I
Y
S
I
D
V
G
N
S
T
Q
T
S
I
R
H
L
H
M
T
P
K
N
M
W
R
T
S
P
L
F
A
T
M
G
I
A
I
P
G
G
L
G
A
K
N
T
Y
P
D
R
Q
-
V
W
N
I
I
G
D
G
A
F
S
M
T
Y
P
D
V
V
T
N
V
R
Y
N
M
P
V
I
N
V
V
F
S
N
T
E
Y
A
F
I
K
N
K
Y
E
-
D
T
N
K
N
L
F
G
----
V
D
F
T
D
-------
V
D
Y
A
K
I
A
E
A
Q
G
A
K
G
F
T
V
S
R
I
E
D
M
D
R
V
M
A
E
A
V
A
A
N
--
K
----
A
G
H
T
V
V
I
D
C
K
I
-------------------------------------------
16
PsiBlast_PDB
84.32
25%
-52
- C5 -
1POX
5
POXB_LACPL
A:
[18-567]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
S
A
E
-
D
W
Y
-
A
-
S
A
N
N
Y
---
Q
--
T
P
-----
L
L
P
E
P
D
V
-----
Q
A
V
T
R
L
T
Q
T
L
L
---
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
---
E
S
T
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
V
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
-
D
T
N
Q
N
D
F
I
G---
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
10
PsiBlast_PDB
83.79
25%
-53
- C5 -
2EZT
6
POXB_LACPL
A:
[26-575]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
E
S
T
---
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
13
PsiBlast_PDB
83.70
25%
-51
- C5 -
4FEG
10
?
A:
[26-575]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
---
E
S
T
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
12
PsiBlast_PDB
83.59
25%
-50
- C5 -
4FEE
10
?
A:
[26-575]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
---
E
S
T
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
9
PsiBlast_PDB
83.43
25%
-52
- C5 -
2EZ9
4
POXB_LACPL
A:
[26-575]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
E
S
T
---
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
24
HHSearch
83.33
21%
-61
* C5 *
2PAN
5
GCL_ECOLI
A:
[25-584]
-----
A
K
M
R
A
V
D
A
A
M
Y
V
L
E
K
E
G
----------
I
T
T
A
F
G
V
P
G
--
A
---
A
I
N
P
F
Y
S
A
M
R
K
H
-
G
G
I
R
H
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
--
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
A
R
-
L
H
K
E
D
F
Q
A
--------
V
D
I
E
A
I
A
K
-----
P
V
S
K
M
A
V
T
----
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
-
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
D
P
D
M
Y
-
E
-
P
L
P
V
-------
Y
K
-----
P
A
A
S
R
-------
M
Q
I
E
K
A
V
E
M
L
I
---
Q
A
E
R
P
V
I
V
A
G
-
G
G
V
-
I
N
-
A
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
D
H
E
L
M
A
G
M
-
V
-
G
L
----
Q
T
A
H
R
Y
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
S
V
E
K
Y
T
E
---------
G
R
K
---------
I
V
H
I
D
I
E
P
T
Q
I
---
G
R
V
L
C
P
D
L
G
I
--
V
--
S
--
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
---
A
G
R
L
P
C
R
K
E
W
V
A
D
C
Q
Q
R
K
R
T
L
L
------------------
R
K
-
T
H
F
D
N
V
----
P
V
K
P
Q
R
V
Y
E
E
M
N
K
A
F
-----
G
R
---
D
V
C
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
-
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
-
A
F
D
M
D
Y
C
V
QLAF
E
N
I
N
S
S
E
V
N
G
Y
G
V
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
Q
---
A
K
--
A
L
M
A
Q
Y
R
V
P
V
V
V
E
V
I
L
E
R
V
T
N
I
-------------------------------------
46
Fugue
83.19
23%
-56
- C5 -
1POX
5
POXB_LACPL
A:
[1-542]
-----
T
N
I
L
A
G
A
A
V
I
K
V
L
E
A
W
-------------
G
V
D
H
L
Y
G
--
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
--
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
--
D
T
F
Q
E
-
M
-----
N
E
N
P
I
Y
A
-----
D
V
A
D
Y
N
V
T
----
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
-
H
Q
-
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
S
A
E
D
W
Y
A
-
S
-
A
N
N
Y
Q
---
T
--
P
L
L
P
E
P
D
V
Q
A
V
T
-------
R
L
T
Q
T
L
L
A
-------
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
--
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
--
V
S
K
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
---
G
K
R
H
-
K
-
T
D
I
--
A
--
V
LA
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
-------------------------
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
----
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
-
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
V
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
-
D
T
N
Q
N
----------
D
F
I
G
V
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
-
A
I
--
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
-------------------------------------
7
PsiBlast_PDB
83.12
25%
-51
- C5 -
2EZ4
5
POXB_LACPL
A:
[26-575]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
E
S
T
---
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
8
PsiBlast_PDB
83.11
25%
-51
- C5 -
2EZ8
5
POXB_LACPL
A:
[26-575]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
E
S
T
---
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
14
PsiBlast_PDB
83.05
25%
-52
- C5 -
4KGD
9
?
A:
[26-575]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
---
E
S
T
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
11
PsiBlast_PDB
83.02
25%
-51
- C5 -
2EZU
5
POXB_LACPL
A:
[26-575]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
E
S
T
---
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
15
PsiBlast_PDB
83.00
25%
-49
- C5 -
1POW
3
POXB_LACPL
A:
[18-567]
--------------------------------
V
D
H
L
Y
G
I
P
G
-----
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
--
V
G
A
M
A
A
A
A
D
A
K
-
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
-
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
-----
A
V
----
N
A
----
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
------
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
--
P
A
E
D
W
-
Y
-
A
S
A
N
S
---
Y
--
Q
T
-----
P
L
L
P
E
-------
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
-
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
-
A
-
N
R
----
V
A
-
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-
F
A
E
V
S
K
-
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
GKR
H
K
T
D
---
I
A
V
--
L
--
A
--
D
A
Q
K
T
L
A
A
I
L
-------
A
Q
V
S
E
R
---
E
S
T
P
W
W
--
Q
A
N
L
A
N
V
K
-
N
W
R
A
Y
L
A
S
L
E
D
K
-
Q
E
G
P
L
Q
A
Y
---------------
Q
V
L
R
A
V
N
K
I
A
-----
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
-
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
----
V
E
F
N
D
-------
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
---
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
P
L
P
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
------------
5
PsiBlast_PDB
82.14
24%
-57
- C5 -
1T9C
7
ILVB_YEAST
A:
[99-635]
-------------------------------------
T
V
F
G
--
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
--
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
-----
V
F
T
G
Q
-
V
P
-----------
T
S
A
I
G
T
-
D
A
F
Q
EAD
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
-
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
-
T
-
T
L
P
S
-----------------
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
---
L
A
K
K
P
V
L
Y
V
G
-
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
-
L
-
G
M
----
H
G
-
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
---
N
K
V
V
-
Q
-
T
Q
I
--
A
V
E
G
--
D
A
T
T
N
L
G
K
M
--
M
S
K
I
F
P
V
K
-------
E
R
S
E
W
F
A
Q
I
N
K
W
--------------
K
K
E
Y
P
Y
A
Y
M
E
E
T
P
G
S
K
I
K
----
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
-----
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
-
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
-------
S
L
F
----
Y
E
H
R
Y
S
H
T
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
---
F
V
--
S
----
T
K
G
P
V
L
L
E
V
E
V
-------------------------------------------
25
HHSearch
81.95
23%
-62
- C5 -
2IHT
7
CEAS_STRCL
A:
[11-571]
------
K
P
T
A
A
H
A
L
L
S
R
L
R
D
H
G
----------
V
G
K
V
F
G
V
V
G
--
R
---
E
A
A
S
I
L
F
D
E
V
---
E
G
I
D
F
V
L
T
R
H
E
F
T
A
G
V
A
A
D
V
L
A
R
I
T
-
G
--
R
P
Q
A
C
W
A
T
L
G
P
G
M
T
N
L
S
T
G
I
A
T
S
V
L
D
R
S
P
V
I
A
L
A
A
Q
S
E
S
H
D
I
F
P
N
D
T
H
Q
C
--------
L
D
S
V
A
I
V
A
-----
P
M
S
K
Y
A
V
E
----
L
Q
R
P
H
E
I
T
D
L
V
D
S
A
V
N
A
A
M
T
-
E
P
V
G
P
S
F
I
S
L
P
V
D
L
L
G
S
S
E
G
I
D
---
P
-
N
-
P
P
A
N
T
PA
K
P
V
G
V
V
-----
A
D
G
W
Q
-------
K
A
A
D
Q
A
A
A
L
L
A
---
E
A
K
H
P
V
L
V
V
G
-
A
A
A
-
I
R
-
S
G
A
V
P
A
I
R
A
L
A
E
R
L
N
I
P
V
I
T
T
Y
I
A
K
G
V
L
P
V
G
H
E
L
N
Y
G
A
-
V
T
G
Y
M
D
G
I
L
N
-
F
P
A
L
Q
T
M
F
A
P
V
D
L
V
L
T
V
G
Y
D
Y
A
E
D
L
R
P
S
M
W
Q
K
G
I
---------
E
K
K
---------
T
V
R
I
S
P
T
V
N
P
I
---
P
R
V
Y
R
P
D
V
D
V
--
V
--
T
--
D
V
L
A
F
V
E
H
F
E
T
A
T
A
S
F
G
A
--
K
Q
R
--
H
D
I
E
P
L
R
A
R
I
A
E
F
L
----------------------
A
D
-
P
E
T
Y
E
D
----
G
M
R
V
H
Q
V
I
D
S
M
N
T
V
M
E
E
A
AE
P
G
---
E
G
T
I
V
S
D
I
G
F
F
R
H
Y
G
V
L
F
A
R
A
D
Q
P
F
G
F
L
T
S
A
G
C
S
S
F
G
Y
G
I
P
A
A
I
G
A
Q
M
A
R
P
-
D
Q
P
T
F
L
I
A
G
D
G
G
F
H
S
N
S
S
D
L
E
T
I
A
R
L
N
L
P
I
V
T
V
V
V
N
N
D
T
N
G
L
I
E
L
Y
Q
N
-
I
G
H
H
R
-
S
H
----
D
P
--
A
V
K
--
F
G
G
V
D
F
V
A
L
A
E
A
N
G
V
D
A
T
R
A
T
N
R
E
E
L
L
A
A
L
R
K
---
G
A
--
E
----
L
G
R
P
F
L
I
E
V
P
V
N
Y
D
F
Q
P
G
G
F
G
A
L
-------------------------------