@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0432: (2016-03-15 )
MTIKNKVIIITGASSGIGKATALLLAEKGAKLVLAARRVEKLEKIVQTIKANSGEAIFAKTDVTKREDNKKLVELAIERYGKVDAIFLNAGIMPNSPLSALKEDEWEQMIDINIKGVLNGIAAVLPSFIAQKSGHIIATSSVAGLKAYPGGAVYGATKWAVRDLMEVLRMESAQEGTNIRTVTIYPAAINTELLETITDKETEQGMTSLYKQYGITPDRIASIVAYAIDQPEDVNVNEFTVGPTSQPW
Atome Classification :
(43 SA)
.........10........20..--......-30-------....-....40.-........-50.--..-.....60........70........80........90-.-.......100.........110.......120.......130.--.......140..-....--.150.......160.......170.......180.......190-.-......200.----.....-.-.-210..-..--...---..220.......230.......240......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTIK
N
K
V
I
I
I
TGASSGI
G
K
A
T
A
L
--
L
L
AEKG-
A
K
-------
L
V
L
A
-
A
R
R
V
E
-
K
-
L
E
K
I
V
Q
T
I
-KAN--SG-
E
A
I
F
AKTDVTKRED
N
K
K
L
V
E
L
A
I
E
RYGK
V
D
A
I
F
L
NAG-I-MPNS
P
L
S
A
--L
K
E
D
E
W
E
Q
M
I
D
I
N
I
K
G
V
L
N
G
I
A
A
V
L
P
S
F
I
A
Q-K--SG
H
I
I
A
TSSVAG-LKAY--PGGAVYG
A
T
K
W
A
V
R
D
L
M
E
V
L
R
M
E
SAQEGT
N
I
R
T
V
T
I
YPAAI
N
T
E
-
L
-
L
E
T
I
T
D
K
E
-
T
----
E
Q
G
M
T
-
S
-
L
-
Y
--
K
Q-YG--I
T
P
---
D
R
I
A
S
I
V
A
Y
AIDQPEDVNVN
E
F
TVGPTSQPW
22
PsiBlast_CBE
89.91
44%
-111
- C1 -
3TFO
5
?
B:
[3-239]
---
M
D
K
V
I
L
I
T
G
A
S
G
G
I
G
E
G
I
A
R
--
E
L
G
V
A
G
-
A
K
-------
I
L
L
G
-
A
R
R
Q
A
-
R
-
I
E
A
I
A
T
E
I
-
R
D
A
--
G
G
-
T
A
L
A
Q
V
L
D
V
T
D
R
H
S
V
A
A
F
A
Q
A
A
V
D
T
W
G
R
I
D
V
L
V
N
N
A
G
-
V
-
M
P
L
S
P
L
A
A
--
V
K
V
D
E
W
E
R
M
I
D
V
N
I
K
G
V
L
W
G
I
G
A
V
L
P
I
M
E
A
Q
-
R
--
S
G
Q
I
I
N
I
G
S
I
G
A
-
L
S
V
V
--
P
T
A
A
V
Y
C
A
T
K
F
A
V
R
A
I
S
D
G
L
R
----
Q
E
S
T
N
I
R
V
T
C
V
N
P
G
V
V
------------------------------------
I
A
--
L
Q
P
---
A
D
I
A
R
A
V
R
Q
V
I
E
A
P
Q
S
V
D
T
T
E
I
T
I
R
P
T
A
---
21
PsiBlast_CBE
87.01
44%
-107
- C1 -
3TFO
5
?
D:
[3-239]
---
M
D
K
V
I
L
I
T
G
A
S
G
G
I
G
E
G
I
A
R
--
E
L
G
V
A
G
-
A
K
-------
I
L
L
G
-
A
R
R
Q
A
-
R
-
I
E
A
I
A
T
E
I
-
R
D
A
--
G
G
-
T
A
L
A
Q
V
L
D
V
T
D
R
H
S
V
A
A
F
A
Q
A
A
V
D
T
W
G
R
I
D
V
L
V
N
N
A
G
-
V
-
M
P
L
S
P
L
A
A
--
V
K
V
D
E
W
E
R
M
I
D
V
N
I
K
G
V
L
W
G
I
G
A
V
L
P
I
M
E
A
Q
-
R
--
S
G
Q
I
I
N
I
G
S
I
G
A
-
L
S
V
V
--
P
T
A
A
V
Y
C
A
T
K
F
A
V
R
A
I
S
D
G
L
R
----
Q
E
S
T
N
I
R
V
T
C
V
N
P
G
V
V
E
---------------------------------
A
-
I
A
--
L
Q
P
---
A
D
I
A
R
A
V
R
Q
V
I
E
A
P
Q
S
V
D
T
T
E
I
T
I
R
P
T
A
---
23
PsiBlast_CBE
85.44
38%
-97
- C1 -
3P19
1
?
D:
[17-251]
-----
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
--
R
F
S
E
E
G
-
H
P
-------
L
L
L
L
-
A
R
R
V
E
-
R
-
L
K
A
L
-------
N
--
L
P
-
N
T
L
C
A
Q
V
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
-
M
-
M
L
L
G
Q
I
D
T
--
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
-
N
--
C
G
T
I
I
N
I
S
S
I
A
G
-
K
K
T
F
--
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
--
A
S
N
V
R
V
M
T
I
A
P
S
A
V
K
T
E
-
L
-
L
S
H
T
T
S
Q
Q
-
I
----
K
D
G
Y
D
-
A
-
W
-
R
--
V
D
-
M
G
GV
L
A
A
---
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
--
1
PsiBlast_PDB
85.06
38%
-95
- C1 -
3P19
1
?
A:
[17-251]
-----
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
--
R
F
S
E
E
G
-
H
P
-------
L
L
L
L
-
A
R
R
V
E
-
R
-
L
K
A
L
-------
N
--
L
P
-
N
T
L
C
A
Q
V
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
-
M
-
M
L
L
G
Q
I
D
T
--
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
-
N
--
C
G
T
I
I
N
I
S
S
I
A
G
-
K
K
T
F
--
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
--
A
S
N
V
R
V
M
T
I
A
P
S
A
V
K
T
E
-
L
-
L
S
H
T
T
S
Q
Q
-
I
----
K
D
G
Y
D
-
A
-
W
-
R
--
V
D
-
M
G
G
V
L
A
A
---
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
--
38
PsiBlast_CBE
83.75
36%
-92
- C1 -
2JAP
2
?
C:
[5-246]
--
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
--
A
L
A
A
E
G
-
A
A
-------
V
A
I
A
-
A
R
R
V
E
-
K
-
L
R
A
L
G
D
E
L
-
T
A
A
--
G
A
-
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
-
I
-
M
L
L
G
P
V
E
D
--
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
-
K
---
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
--
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
--
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
-
R
G
H
I
T
H
T
A
-
T
KEMY
E
Q
R
I
S
-
Q
-
I
-
R
--
K
------
L
Q
A
---
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
--
14
PsiBlast_PDB
83.57
36%
-92
- C1 -
2JAP
2
?
A:
[5-246]
--
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
--
A
L
A
A
E
G
-
A
A
-------
V
A
I
A
-
A
R
R
V
E
-
K
-
L
R
A
L
G
D
E
L
-
T
A
A
--
G
A
-
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
-
I
-
M
L
L
G
P
V
E
D
--
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
-
K
---
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
--
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
--
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
-
R
G
H
I
T
H
T
A
-
T
K
E
M
Y
E
Q
R
I
S
-
Q
-
I
-
R
--
K
------
L
Q
A
---
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
--
135
HHSearch
83.22
35%
-93
- C1 -
2JAH
1
?
A:
[4-245]
-
A
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
--
A
L
A
A
E
G
-
A
A
-------
V
A
I
A
-
A
R
R
V
E
-
K
-
L
R
A
L
G
D
E
L
-
T
A
A
--
G
A
-
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
-
I
-
M
L
L
G
P
V
E
D
--
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
--
S
--
K
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
--
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
--
E
R
G
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
-
R
G
H
I
T
H
T
A
-
T
----
K
E
M
Y
E
Q
R
-
I
-
S
--
Q
I
-
R
K
--
L
Q
A
---
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
---
37
PsiBlast_CBE
82.78
36%
-91
- C1 -
2JAP
2
?
D:
[5-246]
--
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
--
A
L
A
A
E
G
-
A
A
-------
V
A
I
A
-
A
R
R
V
E
-
K
-
L
R
A
L
G
D
E
L
-
T
A
A
--
G
A
-
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
-
I
-
M
L
L
G
P
V
E
D
--
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
-
K
---
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
--
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
--
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
-
R
G
H
I
T
H
T
A
-
T
KEMY
E
Q
R
I
S
-
Q
-
I
-
R
--
K
------
L
Q
A
---
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
--
39
PsiBlast_CBE
82.77
36%
-94
- C1 -
2JAP
2
?
B:
[5-246]
--
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
--
A
L
A
A
E
G
-
A
A
-------
V
A
I
A
-
A
R
R
V
E
-
K
-
L
R
A
L
G
D
E
L
-
T
A
A
--
G
A
-
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
-
I
-
M
L
L
G
P
V
E
D
--
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
-
K
---
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
--
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
--
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
-
R
G
H
I
T
H
T
A
-
T
K
E
M
Y
E
Q
R
I
S
-
Q
-
I
-
R
--
K
------
L
Q
A
---
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
--
29
PsiBlast_CBE
80.45
33%
-107
- C1 -
3RKR
5
?
D:
[26-259]
-
S
L
S
G
Q
V
A
V
V
T
G
A
S
R
G
I
G
A
A
I
A
R
--
K
L
G
S
L
G
-
A
R
-------
V
V
L
T
-
A
R
D
V
E
-
K
-
L
R
A
V
E
R
E
I
-
V
A
A
--
G
G
-
E
A
E
S
H
A
C
D
L
S
H
S
D
A
I
A
A
F
A
T
G
V
L
A
A
H
G
R
C
D
V
L
V
N
N
A
G
-
V
G
W
F
G
G
P
L
H
T
--
M
K
P
A
E
W
D
A
L
I
A
V
N
L
K
A
P
Y
L
L
L
R
A
F
A
P
A
M
I
A
A
-
K
--
R
G
H
I
I
N
I
S
S
L
A
G
-
K
N
P
V
--
A
D
G
A
A
Y
T
A
S
K
W
G
L
N
G
L
M
T
S
A
A
E
E
L
R
Q
H
--
Q
V
R
V
S
L
V
A
P
G
S
V
R
------------------------------------
A
--
I
E
P
---
D
D
I
A
D
V
V
A
L
L
A
T
Q
A
D
Q
S
F
I
S
E
V
L
V
R
P
T
----
25
PsiBlast_CBE
79.54
38%
-105
- C1 -
3P19
1
?
B:
[17-251]
-----
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
--
R
F
S
E
E
G
-
H
P
-------
L
L
L
L
-
A
R
R
V
E
-
R
-
L
K
A
L
-------
N
--
L
P
-
N
T
L
C
A
Q
V
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
-
M
-
M
L
L
G
Q
I
D
T
--
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
-
N
--
C
G
T
I
I
N
I
S
S
I
A
G
-
K
K
T
F
--
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
--
A
S
N
V
R
V
M
T
I
A
P
S
A
V
K
T
E
-
L
-
L
S
-----------------------------
G
GV
L
A
A
---
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
--
31
PsiBlast_CBE
79.14
33%
-107
- C1 -
3RKR
5
?
B:
[26-259]
-
S
L
S
G
Q
V
A
V
V
T
G
A
S
R
G
I
G
A
A
I
A
R
--
K
L
G
S
L
G
-
A
R
-------
V
V
L
T
-
A
R
D
V
E
-
K
-
L
R
A
V
E
R
E
I
-
V
A
A
--
G
G
-
E
A
E
S
H
A
C
D
L
S
H
S
D
A
I
A
A
F
A
T
G
V
L
A
A
H
G
R
C
D
V
L
V
N
N
A
G
-
V
G
W
F
G
G
P
L
H
T
--
M
K
P
A
E
W
D
A
L
I
A
V
N
L
K
A
P
Y
L
L
L
R
A
F
A
P
A
M
I
A
A
-
K
--
R
G
H
I
I
N
I
S
S
L
A
G
-
K
N
P
V
--
A
D
G
A
A
Y
T
A
S
K
W
G
L
N
G
L
M
T
S
A
A
E
E
L
R
Q
H
--
Q
V
R
V
S
L
V
A
P
G
S
V
R
------------------------------------
A
--
I
E
P
---
D
D
I
A
D
V
V
A
L
L
A
T
Q
A
D
Q
S
F
I
S
E
V
L
V
R
P
T
----
3
PsiBlast_PDB
78.39
33%
-104
- C1 -
3RKR
5
?
A:
[26-259]
-
S
L
S
G
Q
V
A
V
V
T
G
A
S
R
G
I
G
A
A
I
A
R
--
K
L
G
S
L
G
-
A
R
-------
V
V
L
T
-
A
R
D
V
E
-
K
-
L
R
A
V
E
R
E
I
-
V
A
A
--
G
G
-
E
A
E
S
H
A
C
D
L
S
H
S
D
A
I
A
A
F
A
T
G
V
L
A
A
H
G
R
C
D
V
L
V
N
N
A
G
-
V
G
W
F
G
G
P
L
H
T
--
M
K
P
A
E
W
D
A
L
I
A
V
N
L
K
A
P
Y
L
L
L
R
A
F
A
P
A
M
I
A
A
-
K
--
R
G
H
I
I
N
I
S
S
L
A
G
-
K
N
P
V
--
A
D
G
A
A
Y
T
A
S
K
W
G
L
N
G
L
M
T
S
A
A
E
E
L
R
Q
H
--
Q
V
R
V
S
L
V
A
P
G
S
V
-------------------------------------
A
--
I
E
P
---
D
D
I
A
D
V
V
A
L
L
A
T
Q
A
D
Q
S
F
I
S
E
V
L
V
R
P
T
----
24
PsiBlast_CBE
78.27
38%
-101
- C1 -
3P19
1
?
C:
[17-251]
-----
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
--
R
F
S
E
E
G
-
H
P
-------
L
L
L
L
-
A
R
R
V
E
-
R
-
L
K
A
L
-------
N
--
L
P
-
N
T
L
C
A
Q
V
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
-
M
-
M
L
L
G
Q
I
D
T
--
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
-
N
--
C
G
T
I
I
N
I
S
S
I
A
G
-
K
K
T
F
--
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
--
A
S
N
V
R
V
M
T
I
A
P
S
A
V
K
T
E
-
L
-
L
S
-----------------------------
G
GV
L
A
A
---
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
--
30
PsiBlast_CBE
77.65
33%
-102
- C1 -
3RKR
3
?
C:
[26-259]
-
S
L
S
G
Q
V
A
V
V
T
G
A
S
R
G
I
G
A
A
I
A
R
--
K
L
G
S
L
G
-
A
R
-------
V
V
L
T
-
A
R
D
V
E
-
K
-
L
R
A
V
E
R
E
I
-
V
A
A
--
G
G
-
E
A
E
S
H
A
C
D
L
S
H
S
D
A
I
A
A
F
A
T
G
V
L
A
A
H
G
R
C
D
V
L
V
N
N
A
G
-
V
G
W
F
G
G
P
L
H
T
--
M
K
P
A
E
W
D
A
L
I
A
V
N
L
K
A
P
Y
L
L
L
R
A
F
A
P
A
M
I
A
A
-
K
--
R
G
H
I
I
N
I
S
S
L
A
G
-
K
N
P
V
--
A
D
G
A
A
Y
T
A
S
K
W
G
L
N
G
L
M
T
S
A
A
E
E
L
R
Q
H
--
Q
V
R
V
S
L
V
A
P
G
S
V
R
-------------------
A
L
G
--------------
A
--
I
E
P
---
D
D
I
A
D
V
V
A
L
L
A
T
Q
A
D
Q
S
F
I
S
E
V
L
V
R
P
T
----
7
PsiBlast_PDB
77.24
33%
-95
- C1 -
3TN7
2
?
A:
[24-253]
----
M
K
V
A
V
I
T
G
A
S
R
G
I
G
E
A
I
A
R
--
A
L
A
R
D
G
-
Y
A
-------
L
A
L
G
-
A
R
S
V
D
-
R
-
L
E
K
I
A
H
E
L
-
M
Q
E
--
Q
G
V
E
V
F
Y
H
H
L
D
V
S
K
A
E
S
V
E
E
F
S
K
K
V
L
E
R
F
G
D
V
D
V
V
V
A
N
A
G
-
L
-
G
Y
F
K
R
L
E
E
--
L
S
E
E
E
F
H
E
M
I
E
V
N
L
L
G
V
W
R
T
L
K
A
F
L
D
S
-
L
K
R
-
T
--
G
G
L
A
L
V
T
T
S
D
V
S
-
A
R
L
I
--
P
Y
G
G
G
Y
V
S
T
K
W
A
A
R
A
L
V
R
T
F
Q
I
E
N
----
P
D
V
R
F
F
E
L
R
P
G
A
V
D
T
Y
-
F
-
G
G
S
K
P
G
K
P
-
K
----
E
K
G
Y
----------------
L
K
P
---
D
E
I
A
E
A
V
R
C
L
L
K
L
P
K
D
V
R
V
E
E
L
M
L
R
S
V
Y
Q
--
33
PsiBlast_CBE
76.00
33%
-92
- C1 -
3TN7
1
?
B:
[24-253]
----
M
K
V
A
V
I
T
G
A
S
R
G
I
G
E
A
I
A
R
--
A
L
A
R
D
G
-
Y
A
-------
L
A
L
G
-
A
R
S
V
D
-
R
-
L
E
K
I
A
H
E
L
-
M
Q
E
--
Q
G
V
E
V
F
Y
H
H
L
D
V
S
K
A
E
S
V
E
E
F
S
K
K
V
L
E
R
F
G
D
V
D
V
V
V
A
N
A
G
-
L
-
G
Y
F
K
R
L
E
E
--
L
S
E
E
E
F
H
E
M
I
E
V
N
L
L
G
V
W
R
T
L
K
A
F
L
D
S
-
L
K
R
-
T
--
G
G
L
A
L
V
T
T
S
D
V
S
-
A
R
L
I
--
P
Y
G
G
G
Y
V
S
T
K
W
A
A
R
A
L
V
R
T
F
Q
I
E
N
----
P
D
V
R
F
F
E
L
R
P
G
A
V
D
T
Y
-
F
-
G
G
S
K
P
G
K
P
-
K
----
E
K
G
Y
----------------
L
K
P
---
D
E
I
A
E
A
V
R
C
L
L
K
L
P
K
D
V
R
V
E
E
L
M
L
R
S
V
Y
Q
--
123
HHSearch
74.86
27%
-94
- C1 -
1XG5
2
DHR11_HUMAN
A:
[28-277]
E
R
W
R
D
R
L
A
L
V
T
G
A
S
G
G
I
G
A
A
V
A
R
--
A
L
V
Q
Q
G
-
L
K
-------
V
V
G
C
-
A
R
T
V
G
-
N
-
I
E
E
L
A
A
E
C
-
K
S
A
GY
P
G
-
T
L
I
P
Y
R
C
D
L
S
N
E
E
D
I
L
S
M
F
S
A
I
R
S
Q
H
S
G
V
D
I
C
I
N
N
A
G
-
L
-
A
R
P
D
T
L
L
S
--
G
S
T
S
G
W
K
D
M
F
N
V
N
V
L
A
L
S
I
C
T
R
E
A
Y
Q
S
M
K
E
R
-
N
VD
D
G
H
I
I
N
I
N
S
M
S
G
-
H
R
V
L
PL
S
V
T
H
F
Y
S
A
T
K
Y
A
V
T
A
L
T
E
G
L
R
Q
E
L
R
E
A
Q
T
H
I
R
A
T
C
I
S
P
G
V
V
E
T
Q
-
F
-
A
F
K
L
H
D
K
D
-
P
----
E
K
A
A
A
-
T
-
Y
-
E
------
C
--
L
K
P
---
E
D
V
A
E
A
V
I
Y
V
L
S
T
P
A
H
I
Q
I
G
D
I
Q
M
R
P
T
----
11
PsiBlast_PDB
74.61
30%
-102
- C1 -
2BD0
1
SPRE_CHLTE
A:
[3-238]
-----
H
I
L
L
I
T
G
A
G
K
G
I
G
R
A
I
A
L
--
E
F
A
R
A
A
-
R
H
H
P
DFEPV
L
V
L
S
-
S
R
T
A
A
-
D
-
L
E
K
I
S
L
E
C
-
R
A
E
--
G
A
-
L
T
D
T
I
T
A
D
I
S
D
M
A
D
V
R
R
L
T
T
H
I
V
E
R
Y
G
H
I
D
C
L
V
N
N
A
G
-
V
-
G
R
F
G
A
L
S
D
--
L
T
E
E
D
F
D
Y
T
M
N
T
N
L
K
G
T
F
F
L
T
Q
A
L
F
A
L
M
E
R
Q
-
H
--
S
G
H
I
F
F
I
T
S
V
A
A
-
T
K
A
F
--
R
H
S
S
I
Y
C
M
S
K
F
G
Q
R
G
L
V
E
T
M
R
L
Y
A
R
K
--
C
N
V
R
I
T
D
V
Q
P
G
A
V
Y
T
P
-
M
-
W
G
K
V
D
D
E
----------
M
Q
-
A
-
L
-
M
---------
M
M
P
---
E
D
I
A
A
P
V
V
Q
A
Y
L
Q
P
S
R
T
V
V
E
E
I
I
L
R
P
T
S
---
12
PsiBlast_PDB
73.99
33%
-92
- C1 -
2UVD
-
?
A:
[2-231]
--
L
K
G
K
V
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
I
--
D
L
A
K
Q
G
-
A
N
-------
V
V
V
N
Y
A
G
N
E
Q
-
K
-
A
N
E
V
V
D
E
I
-
K
K
L
--
G
S
-
D
A
I
A
V
R
A
D
V
A
N
A
E
D
V
T
N
M
V
K
Q
T
V
D
V
F
G
Q
V
D
I
L
V
N
N
A
G
-
V
-
T
K
D
N
L
L
M
R
--
M
K
E
E
E
W
D
T
V
I
N
T
N
L
K
G
V
F
L
C
T
K
A
V
S
R
F
M
M
R
Q
-
R
--
H
G
R
I
V
N
I
A
S
V
V
G
-
V
T
G
N
--
P
G
Q
A
N
Y
V
A
A
K
A
G
V
I
G
L
T
K
T
S
A
K
E
L
A
S
R
--
N
I
T
V
N
A
I
A
P
G
F
I
A
T
D
-
M
-
T
D
V
L
-
D
E
N
-
I
----
K
A
E
M
L
-
K
-
L
-
I
PA
A
Q
-
F
G
--
E
A
Q
---
D
I
A
N
A
V
T
F
F
A
S
D
Q
S
K
----------------
28
PsiBlast_CBE
73.62
34%
-94
- C1 -
3RKU
1
YM71_YEAST
B:
[34-278]
-----
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
EY
L
E
A
S
N
G
D
M
K
-------
L
I
L
A
-
A
R
R
L
E
-
K
-
L
E
E
L
K
K
T
I
-
D
Q
E
FP
N
A
-
K
V
H
V
A
Q
L
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
-
L
G
S
D
R
V
G
Q
--
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
-
N
--
S
G
D
I
V
N
L
G
S
I
A
G
-
R
D
A
Y
--
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
--
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
E
---
F
S
L
V
R
Y
R
G
-
N
----
E
E
Q
A
K
-
N
-
V
-
Y
--
K
D
-----
T
T
P
LMA
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
--
2
PsiBlast_PDB
73.31
34%
-92
- C1 -
3RKU
1
YM71_YEAST
A:
[34-278]
-----
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
G
D
M
K
-------
L
I
L
A
-
A
R
R
L
E
-
K
-
L
E
E
L
K
K
T
I
-
D
Q
E
F
P
N
A
-
K
V
H
V
A
Q
L
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
-
L
G
S
D
R
V
G
Q
--
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
-
N
--
S
G
D
I
V
N
L
G
S
I
A
G
-
R
D
A
Y
--
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
--
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
E
---
F
S
L
V
R
Y
R
G
-
N
----
E
E
Q
A
K
-
N
-
V
-
Y
--
K
D
-----
T
T
P
LM
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
--
26
PsiBlast_CBE
72.83
34%
-94
- C1 -
3RKU
1
YM71_YEAST
D:
[34-278]
-----
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
EY
L
E
A
S
N
G
D
M
K
-------
L
I
L
A
-
A
R
R
L
E
-
K
-
L
E
E
L
K
K
T
I
-
D
Q
E
FP
N
A
-
K
V
H
V
A
Q
L
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
-
L
G
S
D
R
V
G
Q
--
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
-
N
--
S
G
D
I
V
N
L
G
S
I
A
G
-
R
D
A
Y
--
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
--
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
E
---
F
S
L
V
R
Y
R
G
-
N
----
E
E
Q
A
K
-
N
-
V
-
Y
--
K
D
-----
T
T
P
LMA
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
--
27
PsiBlast_CBE
72.34
34%
-92
- C1 -
3RKU
1
YM71_YEAST
C:
[34-278]
-----
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
EY
L
E
A
S
N
G
D
M
K
-------
L
I
L
A
-
A
R
R
L
E
-
K
-
L
E
E
L
K
K
T
I
-
D
Q
E
FP
N
A
-
K
V
H
V
A
Q
L
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
-
L
G
S
D
R
V
G
Q
--
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
-
N
--
S
G
D
I
V
N
L
G
S
I
A
G
-
R
D
A
Y
--
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
--
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
E
---
F
S
L
V
R
Y
R
G
-
N
----
E
E
Q
A
K
-
N
-
V
-
Y
--
K
D
-----
T
T
P
LMA
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
--
130
HHSearch
68.78
31%
-93
- C1 -
1GEE
1
DHG_BACME
A:
[4-237]
-
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
-
D
E
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
-
E
N
P
V
S
S
H
E
--
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
--
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
-
N
A
E
K
F
A
D
P
E
Q
----
R
A
D
V
E
-
S
M
I
-
P
--
M
G
-
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
---------------
53
PsiBlast_CBE
68.36
33%
-92
- C1 -
1GEE
1
DHG_BACME
E:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
57
PsiBlast_CBE
68.24
33%
-92
- C1 -
1GCO
1
DHG_BACME
E:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
55
PsiBlast_CBE
68.23
33%
-91
- C1 -
1GEE
1
DHG_BACME
A:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
56
PsiBlast_CBE
68.17
33%
-91
- C1 -
1GCO
1
DHG_BACME
F:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
52
PsiBlast_CBE
68.15
33%
-90
- C1 -
1GEE
1
DHG_BACME
F:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
76
PsiBlast_CBE
68.05
33%
-97
- C1 -
1G6K
1
DHG_BACME
E:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
-
A
--
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
75
PsiBlast_CBE
68.04
33%
-95
- C1 -
1G6K
1
DHG_BACME
F:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
-
A
--
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
54
PsiBlast_CBE
67.94
33%
-91
- C1 -
1GEE
1
DHG_BACME
B:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
59
PsiBlast_CBE
67.84
33%
-91
- C1 -
1GCO
1
DHG_BACME
A:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
88
PsiBlast_CBE
67.70
33%
-93
- C1 -
1RWB
1
DHG_BACME
A:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
77
PsiBlast_CBE
67.70
33%
-95
- C1 -
1G6K
1
DHG_BACME
B:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
-
A
--
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
78
PsiBlast_CBE
67.60
33%
-94
- C1 -
1G6K
1
DHG_BACME
A:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
-
A
--
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
87
PsiBlast_CBE
67.53
33%
-92
- C1 -
1RWB
1
DHG_BACME
B:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
85
PsiBlast_CBE
67.49
33%
-92
- C1 -
1RWB
1
DHG_BACME
F:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
86
PsiBlast_CBE
67.12
33%
-94
- C1 -
1RWB
1
DHG_BACME
E:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
58
PsiBlast_CBE
67.08
33%
-90
- C1 -
1GCO
1
DHG_BACME
B:
[5-230]
--
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
--
R
F
A
T
E
K
-
A
K
-------
V
V
V
N
-
Y
R
S
K
E
D
E
-
A
N
S
V
L
E
E
I
-
K
K
V
--
G
G
-
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-
L
---
E
N
P
V
S
S
HE
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I-
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
--
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
P
E
-
Q
----
R
A
D
V
E
-
S
-
M
-
I
--
P
M
G
Y
I
--
G
E
P
---
E
E
I
A
A
V
A
A
W
----------------------
8
PsiBlast_PDB
61.36
30%
-85
- C1 -
3PK0
5
?
A:
[8-226]
--
L
Q
G
R
S
V
V
V
T
G
G
T
K
G
I
G
R
G
I
A
T
--
V
F
A
R
A
G
-
A
N
-------
V
A
V
A
-
G
R
S
T
A
-
D
-
I
D
A
C
V
A
D
L
D
Q
L
G
--
S
G
-
K
V
I
G
V
Q
T
D
V
S
D
R
A
Q
C
D
A
L
A
G
R
A
V
E
E
F
G
G
I
D
V
V
C
A
N
A
G
-
V
-
F
P
D
A
P
L
A
T
--
M
T
P
E
Q
L
N
G
I
F
A
V
N
V
N
G
T
F
Y
A
V
Q
A
C
L
D
A
L
I
A
S
-
G
--
S
G
R
V
V
L
T
S
S
I
T
G
P
I
T
G
Y
--
P
G
W
S
H
Y
G
A
T
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
L
A
P
H
--
K
I
T
V
N
A
I
M
P
G
N
I
M
T
E
G
L
-
L
E
-----
N
-
G
----
E
E
Y
I
A
-
S
-
M
-
A
--
R
----------------
S
I
P
A
G
A
L
G
T
P
E
D
I
G
-------------
6
PsiBlast_PDB
59.98
34%
-88
- C1 -
3OSU
15
FABG_STAAM
A:
[5-224]
-----
K
S
A
L
V
T
G
A
S
R
G
I
G
R
S
I
A
L
--
Q
L
A
E
E
G
-
Y
N
-------
V
A
V
N
Y
A
G
S
K
E
-
K
-
A
E
A
V
V
E
E
I
-
K
A
K
--
G
V
-
D
S
F
A
I
Q
A
N
V
A
D
A
D
E
V
K
A
M
I
K
E
V
V
S
Q
F
G
S
L
D
V
L
V
N
N
A
G
-
I
-
T
R
D
N
L
L
M
R
--
M
K
E
Q
E
W
D
D
V
I
D
T
N
L
K
G
V
F
N
C
I
Q
K
A
T
P
Q
M
L
R
Q
-
R
--
S
G
A
I
I
N
L
S
S
V
V
G
-
A
V
G
N
--
P
G
Q
A
N
Y
V
A
T
K
A
G
V
I
G
L
T
K
S
A
A
R
E
L
A
S
R
G
I
T
V
N
A
V
A
--
P
G
F
I
V
S
D
-
M
-
T
D
A
L
S
D
E
L
-
K
----
E
Q
M
L
T
-
Q
-
I
P
L
--
A
R
-
F
G
--
Q
D
T
---
D
-
I
A
N
T
V
A
F
----------------------