@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0437: (2016-03-15 )
MTYLVTGATGGLGGYALNYLKELVPMSDIYALVRSKEKGADLKAAGFNIRVGDYSDAESMKQAFAGIDRVLFVSGAPGNRQVEHENVINAAKKAGVSYIAYTSFAGADKSTSALAEDHFFTEKVIEKSGIAHTFLRNNWYFENEMPMIGGALSAGKFVYAAENGKVGWALKREYAEVAAKAVAGAGFPEILELSGPLMTYEELTKALKEATGKDFDVISSDDKGFVENLVSVGLPQPVAEMFLSFQHDIKNDQLDVTSDDFEKALGKPLTNRVDALRELLK
Atome Classification :
(20 SA)
-----------.........10........20...-...------..30.-...--...---.--40--------..-...----....50........60........70....--..-------------.----.80---.-..-------------.-----....90....-....100......-.-------------110----------------..-----.......120.......----..-------130.......140-...-.---.-------.----...---150-.---...--..--...---160-.---........170.......180..--..--..-.--190--..--.-.-.-.-.-..200.......210...---....220....------...230.......--.240.......250.---...-.----..260-....-..-.-270-----------........280---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------
M
T
Y
L
V
TGATGG
L
G
G
Y
A
L
N
Y
L
K
E
LV-
P
M
S
------
D
I
Y
A
L
-
V
RS--KEK---G--A---------DL-KAA----
G
F
N
I
R
VGDYS
D
A
E
S
M
K
Q
A
F
AGI
D
R
V
L
F
V
SG--AP-------------G----NRQ---
V
-
E
H
-------------
E
-----
N
V
I
N
A
A
K
KAG-
V
S
Y
I
A
Y
TSFAGAD-K-------------
S
------------------
T
S
-----
A
L
A
EDH
F
F
--
T
E
K
V
I
E
K----SG-------IA
H
T
F
LRN
N
W
Y
---FEN-E---M-------P----MIG---G---A---LSA--
G
K
--
F
V
Y
---
A
---A---ENG
K
V
G
W
A
L
K
R
E
Y
A
E
V
A
A
K
A
VAG--AG--
F
P
-
E
--
I
----
L
E--L-S-G-P-L-M
T
Y
E
E
L
T
K
A
L
K
E
ATGKDF---DVISSDD
K
G
F
V
------
E
N
L
V
-SVGLPQ
P
V
--
A
E
M
F
L
S
F
Q
H
DIKNDQ---LDV-
T
----
S
D
D
F
E
-
K
A
LG-K
P
-
L
-
T
N
------------
R
V
D
A
L
R
E
L
LK----
3
PsiBlast_PDB
97.52
36%
-94
- C2 -
2VRB
1
?
A:
[2-285]
------------
S
I
A
V
T
G
A
T
G
Q
L
G
G
L
V
I
Q
H
L
L
K
K
V
-
P
A
S
------
Q
I
I
A
I
-
V
R
N
--
V
E
K
---
A
--
S
---------
T
L
-
A
D
Q
----
G
V
E
V
R
H
G
D
Y
N
Q
P
E
S
L
Q
K
A
F
A
G
V
S
K
L
L
F
I
S
G
--
P
H
-------------
Y
----
D
N
T
L
L
I
V
-
Q
H
-------------
A
-----
N
V
V
K
A
A
R
D
A
G
-
V
K
H
I
A
Y
T
G
Y
A
F
A
E
-
E
-------------
S
------------------
I
I
-----
P
L
A
H
V
H
L
A
--
T
E
Y
A
I
R
T
----
T
N
-------
I
P
Y
T
F
L
R
N
A
L
Y
TDF
F
V
N
-
E
----------------
G
L
R
---
A
---
S
---
T
E
S
--
G
A
--
I
V
T
---
N
---
A
---
G
S
G
I
V
N
S
V
T
R
N
E
L
A
L
A
A
A
T
V
L
T
E
--
E
G
--
H
E
-
N
--
K
----
T
Y
NL
V
-
S
-
N
-
Q
-
P
-
W
T
F
D
E
L
A
Q
I
L
S
E
V
S
G
K
K
V
V
H
Q
P
V
S
F
E
E
E
K
N
F
---------
L
V
-
N
A
G
V
P
E
P
F
--
A
E
I
T
A
A
I
Y
D
A
I
S
K
G
E
---
A
S
K
-
T
----
S
D
D
L
Q
-
K
L
I
G
-
S
--
L
-
T
P
------------
L
K
E
T
V
K
Q
A
L
-----
50
Fugue
96.63
37%
-100
- C2 -
2ZCU
1
QOR2_ECOLI
A:
[1-283]
------------
M
I
A
I
T
G
A
T
G
Q
L
G
H
Y
V
I
E
S
L
M
K
T
V
-
P
A
S
------
Q
I
V
A
I
-
V
R
N
--
P
A
K
---
A
--
Q
---------
A
L
-
A
A
Q
----
G
I
T
V
R
Q
A
D
Y
G
D
E
A
A
L
T
S
A
L
Q
G
V
E
K
L
L
L
I
S
P
------------------------------
Q
H
-------------
R
-----
N
V
I
N
A
A
K
A
A
G
-
V
K
F
I
A
Y
T
S
L
L
H
A
D
-
T
-------------
S
------------------
P
L
-----
G
L
A
D
E
H
I
E
--
T
E
K
M
L
A
D
----
S
G
-------
I
V
Y
T
L
L
R
N
G
W
Y
---
S
E
N
-
Y
---
L
-------
A
----
S
A
P
---
A
---
A
---
L
E
H
--
G
V
--
F
I
G
---
A
---
A
---
G
D
G
K
I
A
S
A
T
R
A
D
Y
A
A
A
A
A
R
V
I
S
E
--
A
G
--
H
E
G
K
--
V
----
Y
E
--
L
-
A
-
G
-
D
S
A
-
W
T
L
T
Q
L
A
A
E
L
T
K
Q
S
G
K
Q
V
---
T
Y
Q
N
L
S
E
A
D
F
A
------
A
A
L
K
-
S
V
G
L
P
D
G
L
--
A
D
M
L
A
D
S
D
V
G
A
S
K
G
G
---
L
F
D
-
D
----
S
K
T
L
S
-
K
L
I
G
-
H
P
-
T
-
T
T
------------
L
A
E
S
V
S
H
L
F
N
----
4
PsiBlast_PDB
95.35
36%
-86
- C2 -
2JL1
6
?
A:
[5-286]
---------------
V
T
G
A
T
G
Q
L
G
G
L
V
I
Q
H
L
L
K
K
V
-
P
A
S
------
Q
I
I
A
I
-
V
R
N
--
V
E
K
---
A
--
S
---------
T
L
-
A
D
Q
----
G
V
E
V
R
H
G
D
Y
N
Q
P
E
S
L
Q
K
A
F
A
G
V
S
K
L
L
F
I
S
G
--
P
H
-------------
Y
----
D
N
T
L
L
I
V
-
Q
H
-------------
A
-----
N
V
V
K
A
A
R
D
A
G
-
V
K
H
I
A
Y
T
G
Y
A
F
A
E
-
E
-------------
S
------------------
I
I
-----
P
L
A
H
V
H
L
A
--
T
E
Y
A
I
R
T
----
T
N
-------
I
P
Y
T
F
L
R
N
A
L
Y
TDF
F
V
N
-
E
----------------
G
L
R
---
A
---
S
---
T
E
S
--
G
A
--
I
V
T
---
N
---
A
---
G
S
G
I
V
N
S
V
T
R
N
E
L
A
L
A
A
A
T
V
L
T
E
--
E
G
--
H
E
-
N
--
K
----
T
Y
NL
V
-
S
-
N
-
Q
-
P
-
W
T
F
D
E
L
A
Q
I
L
S
E
V
S
G
K
K
V
V
H
Q
P
V
S
F
E
E
E
K
N
F
---------
L
V
-
N
A
G
V
P
E
P
F
--
T
E
I
T
A
A
I
Y
D
A
I
S
K
G
E
---
A
S
K
-
T
----
S
D
D
L
Q
-
K
L
I
G
-
S
--
L
-
T
P
------------
L
K
E
T
V
K
Q
A
L
K
----
2
PsiBlast_PDB
95.05
37%
-88
- C2 -
2ZCV
4
QOR2_ECOLI
A:
[4-281]
---------------
I
T
G
A
T
G
Q
L
G
H
Y
V
I
E
S
L
M
K
T
V
-
P
A
S
------
Q
I
V
A
I
-
V
R
N
--
P
A
K
---
A
--
Q
---------
A
L
-
A
A
Q
----
G
I
T
V
R
Q
A
D
Y
G
D
E
A
A
L
T
S
A
L
Q
G
V
E
K
L
L
L
I
S
S
--
S
E
V------------
G
----
Q
R
A
---
P
-
Q
H
-------------
R
-----
N
V
I
N
A
A
K
A
A
G
-
V
K
F
I
A
Y
T
S
L
L
H
A
D
-
T
-------------
S
------------------
P
L
-----
G
L
A
D
E
H
I
E
--
T
E
K
M
L
A
D
----
S
G
-------
I
V
Y
T
L
L
R
N
G
W
Y
---
S
E
N
-
Y
---
L
-------
A
----
S
A
P
---
A
---
A
---
L
E
H
--
G
V
--
F
I
G
---
A
---
A
---
G
D
G
K
I
A
S
A
T
R
A
D
Y
A
A
A
A
A
R
V
I
S
E
--
A
G
--
H
E
G
K
--
V
----
Y
E
--
L
-
A
-
G
D
S
-
A
-
W
T
L
T
Q
L
A
A
E
L
T
K
Q
S
G
K
Q
V
---
T
Y
Q
N
L
S
E
A
D
F
A
------
A
A
L
K
-
S
V
G
L
P
D
G
L
--
A
D
M
L
A
D
S
D
V
G
A
S
K
G
G
---
L
F
D
-
D
----
S
K
T
L
S
-
K
L
I
G
-
H
P
-
T
-
T
T
------------
L
A
E
S
V
S
H
L
------
30
HHSearch
94.36
36%
-97
- C2 -
2ZCU
1
QOR2_ECOLI
A:
[1-282]
------------
M
I
A
I
T
G
A
T
G
Q
L
G
H
Y
V
I
E
S
L
M
K
T
V
P
A
-
S
------
Q
I
V
A
I
-
V
R
N
--
P
A
K
---
A
--
Q
---------
A
L
-
A
A
Q
----
G
I
T
V
R
Q
A
D
Y
G
D
E
A
A
L
T
S
A
L
Q
G
V
E
K
L
L
L
I
S
-----------------------------
P
-
Q
H
-------------
R
-----
N
V
I
N
A
A
K
A
A
G
-
V
K
F
I
A
Y
T
S
L
L
H
A
D
-
T
-------------
S
------------------
P
L
-----
G
L
A
D
E
H
I
E
--
T
E
K
M
L
A
D
----
S
G
-------
I
V
Y
T
L
L
R
N
G
W
Y
---
S
E
N
-
Y
---
L
-------
A
----
S
A
P
---
A
---
A
---
L
E
H
--
G
V
--
F
-
I
---
G
---
A
A--
G
D
G
K
I
A
S
A
T
R
A
D
Y
A
A
A
A
A
R
V
I
S
E
A-
G
H
--
E
G
-
K
--
V
----
Y
E
--
L
-
A
-
G
-
D
-
S
A
W
T
L
T
Q
L
A
A
E
L
T
K
Q
S
G
K
Q
V
---
T
Y
Q
N
L
S
E
A
D
F
A
------
A
A
L
K
-
S
V
G
L
P
D
G
L
--
A
D
M
L
A
D
S
D
V
G
A
S
K
G
G
---
L
F
D
-
D
----
S
K
T
L
S
-
K
L
I
G
-
H
P
-
T
-
T
T
------------
L
A
E
S
V
S
H
L
F
-----
1
PsiBlast_PDB
94.25
37%
-96
- C2 -
2ZCU
1
QOR2_ECOLI
A:
[4-281]
---------------
I
T
G
A
T
G
Q
L
G
H
Y
V
I
E
S
L
M
K
T
V
-
P
A
S
------
Q
I
V
A
I
-
V
R
N
--
P
A
K
---
A
--
Q
---------
A
L
-
A
A
Q
----
G
I
T
V
R
Q
A
D
Y
G
D
E
A
A
L
T
S
A
L
Q
G
V
E
K
L
L
L
I
S
-----------------------------
P
-
Q
H
-------------
R
-----
N
V
I
N
A
A
K
A
A
G
-
V
K
F
I
A
Y
T
S
L
L
H
A
D
-
T
-------------
S
------------------
P
L
-----
G
L
A
D
E
H
I
E
--
T
E
K
M
L
A
D
----
S
G
-------
I
V
Y
T
L
L
R
N
G
W
Y
---
S
E
N
-
Y
---
L
-------
A
----
S
A
P
---
A
---
A
---
L
E
H
--
G
V
--
F
I
G
---
A
---
A
---
G
D
G
K
I
A
S
A
T
R
A
D
Y
A
A
A
A
A
R
V
I
S
E
--
A
G
--
H
E
G
K
--
V
----
Y
E
--
L
-
A
-
G
D
S
-
A
-
W
T
L
T
Q
L
A
A
E
L
T
K
Q
S
G
K
Q
V
---
T
Y
Q
N
L
S
E
A
D
F
A
------
A
A
L
K
-
S
V
G
L
P
D
G
L
--
A
D
M
L
A
D
S
D
V
G
A
S
K
G
G
---
L
F
D
-
D
----
S
K
T
L
S
-
K
L
I
G
-
H
P
-
T
-
T
T
------------
L
A
E
S
V
S
H
L
------
31
HHSearch
93.71
35%
-89
- C2 -
2JL1
6
?
A:
[1-285]
-----------
F
S
I
A
V
T
G
A
T
G
Q
L
G
G
L
V
I
Q
H
L
L
K
K
V
P
A
-
S
------
Q
I
I
A
I
-
V
R
N
--
V
E
K
---
A
--
S
---------
T
L
-
A
D
Q
----
G
V
E
V
R
H
G
D
Y
N
Q
P
E
S
L
Q
K
A
F
A
G
V
S
K
L
L
F
I
S
G
--
P
H
-------------
Y
D
N
T
-
L
L
I
---
V
-
Q
H
-------------
A
-----
N
V
V
K
A
A
R
D
A
G
-
V
K
H
I
A
Y
T
G
Y
A
F
A
E
-
E
-------------
S
------------------
I
I
-----
P
L
A
H
V
H
L
A
--
T
E
Y
A
I
R
T
----
T
N
-------
I
P
Y
T
F
L
R
N
A
L
Y
---
T
D
F
-
F
---
V
N------
E
----
G
L
R
---
A
---
S
---
T
E
S
--
G
A
--
I
V
T
---
N
---
A
---
G
S
G
I
V
N
S
V
T
R
N
E
L
A
L
A
A
A
T
V
L
T
E
E-
G
H
--
E
N
-
K
--
T
----
Y
N
--
L
-
V
-
S
-
N
-
Q
P
W
T
F
D
E
L
A
Q
I
L
S
E
V
S
G
K
K
V
---
V
H
Q
P
V
S
F
E
E
E
K
------
N
F
L
V
-
N
A
G
V
P
E
P
F
--
T
E
I
T
A
A
I
Y
D
A
I
S
K
G
E
---
A
S
K
-
T
----
S
D
D
L
Q
-
K
L
I
G
-
S
--
L
-
T
P
------------
L
K
E
T
V
K
Q
A
L
-----
29
HHSearch
80.47
25%
-70
- C2 -
3E48
2
?
A:
[1-279]
-----------
M
N
I
M
L
T
G
A
T
G
H
L
G
T
H
I
T
N
Q
A
I
A
N
H
-
I
-
D
------
H
F
H
I
G
-
V
R
N
--
V
E
K
---
V
--
P
---------
D
D
-
W
R
G
----
K
V
S
V
R
Q
L
D
Y
F
N
Q
E
S
M
V
E
A
F
K
G
M
D
T
V
V
F
I
P
S
--
I
I
-------------
H
PSF-
K
R
I
---
P
-
E
V
-------------
E
-----
N
L
V
Y
A
A
K
Q
S
G
-
V
A
H
I
I
F
I
G
Y
Y
A
D
Q
H
N
-------------
N
------------------
P
F
-----
H
M
S
P
Y
F
G
Y
--
A
S
R
L
L
S
T
----
S
G
-------
I
D
Y
T
Y
V
R
M
A
M
Y
---
M
D
P
-
L
---
K
-------
P
----
Y
L
P
---
E
---
L
---
M
N
M
--
H
K
--
L
I
Y
---
P
---
A
---
G
D
G
R
I
N
Y
I
T
R
N
D
I
A
R
G
V
I
A
I
I
K
N
P-
D
T
--
W
G
-
K
--
R
----
Y
L
--
L
-
S
-
G
-
Y
-
S
-
Y
D
M
K
E
L
A
A
I
L
S
E
A
S
G
T
E
I
---
K
Y
E
P
V
S
L
E
T
F
A
------
E
M
Y
D
-
E
---
P
K
G
F
--
G
A
L
L
A
S
M
Y
H
A
G
A
R
G
L
---
L
D
Q
-
E
----
S
N
D
F
K
-
Q
L
V
N
-
D
Q
-
P
-
Q
T
------------
L
Q
S
F
L
Q
E
-------
6
PsiBlast_PDB
72.92
26%
-63
- C2 -
3E48
2
?
A:
[5-272]
---------------
L
T
G
A
T
G
H
L
G
T
H
I
T
N
--
Q
A
I
A
-
N
H
I
------
D
H
F
H
I
G
V
R
N
--
V
E
K
---
V
--
P
---------
D
D
-
W
R
G
----
K
V
S
V
R
Q
L
D
Y
F
N
Q
E
S
M
V
E
A
F
K
G
M
D
T
V
V
F
I
P
S
II
H
P
-------------
S
----
F
K
R
---
I
P
E
V
-------------
E
-----
N
L
V
Y
A
A
K
Q
S
G
-
V
A
H
I
I
F
I
G
Y
Y
-
A
D
-
Q
-------------
H
------------------
N
N
-----
P
F
H
M
S
P
Y
F
G
Y
A
S
R
L
L
S
T
----
S
G
-------
I
D
Y
T
Y
V
R
M
A
M
Y
---
M
D
P
-
L
---
K
-------
P
----
Y
L
P
---
E
---
L
---
M
N
M
--
H
K
--
L
I
Y
---
P
---
A
---
G
D
G
R
I
N
Y
I
T
R
N
---
D
I
A
R
G
V
I
A
I
--
I
K
--
N
P
-
D
--
T
WG
K
R
Y
L
--
L
-
S
-
G
-
Y
-
S
-
Y
D
M
K
E
L
A
A
I
L
S
E
A
S
G
T
E
I
---
K
Y
E
P
V
S
L
E
T
F
A
------
E
M
Y
D
-
E
---
P
K
G
F
--
G
A
L
L
A
S
M
Y
H
A
G
A
R
G
L
---
L
D
Q
-
E
----
S
N
D
F
K
-
Q
L
V
N
D
Q
P
-
Q
-
T
---------------------------
34
HHSearch
71.74
15%
-80
- C2 -
3C1O
1
?
A:
[5-308]
-----------
E
K
I
I
I
Y
G
G
T
G
Y
I
G
K
F
M
V
R
A
S
L
S
F
S
---
H
------
P
T
F
I
Y
-
A
R
P
--
L
T
P
---
D
--
S
T
P
S
S
V
Q
L
R
E
E
F
-
R
S
M
----
G
V
T
I
I
E
G
E
M
E
E
H
E
K
M
V
S
V
L
K
Q
V
D
I
V
I
S
A
L
P
--
F
P
-------------------
M
I
---
S
-
S
Q
-------------
I
-----
H
I
I
N
A
I
K
A
A
G
N
I
K
R
F
L
P
-
S
D
F
G
C
E
E
D
RIKPL
P
-------
P
------------------
F
E
-----
S
V
L
E
K
K
R
I
--
I
R
R
A
I
E
A
----
A
A
-------
L
P
Y
T
Y
V
S
A
N
C
F
---
G
A
Y
-
F
---
V
N
------
Y
----
L
L
H
PSP
H
---
P
---
N
R
N
--
D
D
--
I
V
I
---
Y
---
G
T--
G
E
T
K
F
V
L
N
Y
E
E
D
I
A
K
Y
T
I
K
V
A
C
D
P-
R
C
--
C
N
-
R
--
I
----
V
I
--
Y
-
R
P
P
-
K
-
N
I
I
S
Q
N
E
L
I
S
L
W
E
A
K
S
G
L
S
F
---
K
K
V
H
M
P
D
E
Q
L
V
------
R
L
S
Q
-
E
L
P
Q
P
Q
N
----
I
P
V
S
I
L
H
S
I
F
V
K
G
D
L--
M
S
Y
-
E
MRKD
D
I
E
A
S
N
L
Y
P
E
-
L
E
-
F
-
T
S
------------
I
D
G
L
L
D
L
F
I
-----
55
Fugue
69.76
19%
-72
- C2 -
2WM3
6
NMRL1_HUMAN
A:
[4-299]
---------DK
K
L
V
V
V
F
G
G
T
G
A
Q
G
G
S
V
A
R
T
L
L
E
D
G
-
T
F
-------
K
V
R
V
V
-
T
R
N
PR
K
K
A
---
A
--
K
---------
E
L
-
R
L
Q
----
G
A
E
V
V
Q
G
D
Q
D
D
Q
V
I
M
E
L
A
L
N
G
A
Y
A
T
F
I
V
T
N
--
Y
W
-------------
E
----
S
C
S
---
Q
-
E
Q
-------------
E
V
K
Q
G
K
L
L
A
D
L
A
R
R
L
G
-
L
H
Y
V
V
Y
S
G
L
E
N
I
K
-
K
-------------
L
------------------
T
A
GRLAA
A
H
F
D
G
K
G
E
--
V
E
E
Y
F
R
D
----
I
G
-------
V
P
M
T
S
V
R
L
P
C
Y
---
F
E
N
-
L
---
L
-------
S
----
H
F
L
---
P
---
Q
---
K
A
P
D-
G
K
--
S
Y
L
---
L
---
S
L
PT
G
D
V
P
M
D
G
M
S
V
S
D
L
G
P
V
V
L
S
L
L
K
M
--
P
E
--
K
Y
-
V
G
Q
N
----
I
G
--
L
-
S
-
T
-
C
-
R
-
H
T
A
E
E
Y
A
A
L
L
T
K
H
T
R
K
V
V
---
H
D
A
K
M
T
P
E
D
Y
E
------
K
L
G
F
-
P
--
G
A
R
D
L
--
A
N
M
F
R
F
Y
A
L
R
P
D
R
D
--------------
I
E
L
T
-
L
R
L
N
-
P
K
-
A
-
L
T
------------
L
D
Q
W
L
E
Q
H
K
G
DFNL
37
HHSearch
69.27
23%
-95
- C2 -
1QYC
-
?
A:
[5-253]
-----------
S
R
I
L
L
I
G
A
T
G
Y
I
G
R
H
V
A
K
A
S
L
D
L
G
---
H
------
P
T
F
L
L
-
V
R
E
--
S
T
A
---
S
--
S
NS
E
K
A
Q
L
L
E
S
F
-
K
A
S
----
G
A
N
I
V
H
G
S
I
D
D
H
A
S
L
V
E
A
V
K
N
V
D
V
V
I
S
T
V
G
--
S
-------------------
L
Q
I
---
E
-
S
Q
-------------
V
-----
N
I
I
K
A
I
K
E
V
G
T
V
K
R
F
F
P
-
S
E
F
G
N
D
V
D
NVHAVE-------
P
------------------
A
K
-----
S
V
F
E
V
K
A
K
--
V
R
R
A
I
E
A
----
E
G
-------
I
P
Y
T
Y
V
S
S
N
C
F
---
A
G
Y
-
F
---
L
-------
R
S---
L
A
Q
---
A
GLT
A
---
P
P
R
--
D
K
--
V
V
I
---
L
---
G
D--
G
N
A
R
V
V
F
V
K
E
E
D
I
G
T
F
T
I
K
A
V
D
D
P-
R
T
--
L
N
-
K
--
T
----
L
Y
--
L
R
L
-
P
-
A
-
N
T
L
S
L
N
E
L
V
A
L
W
E
K
K
I
D
K
T
L
---
E
K
A
Y
V
P
E
E
E
V
L
------
K
L
I
-----------------------------------------------------------------------------------
51
Fugue
68.79
19%
-75
- C2 -
2EXX
2
NMRL1_HUMAN
A:
[1-305]
LY
K
K
A
G
L
M
VD
K
K
L
V
V
V
F
G
G
T
G
A
Q
G
G
S
V
A
R
T
L
L
E
D
--
G
T
F
------
K
V
R
V
V
-
T
R
N
PR
K
K
A
---
A
--
K
---------
E
L
-
R
L
Q
----
G
A
E
V
V
Q
G
D
Q
D
D
Q
V
I
M
E
L
A
L
N
G
A
Y
A
T
F
I
V
T
N
--
Y
W
-------------
E
----
S
C
S
---
Q
-
E
Q
-------------
E
V
K
Q
G
K
L
L
A
D
L
A
R
R
L
G
-
L
H
Y
V
V
Y
S
G
L
E
N
I
K
-
K
-------------
L
------------------
T
A
GRLAA
A
H
F
D
G
K
G
E
--
V
E
E
Y
F
R
D
----
I
G
-------
V
P
M
T
S
V
R
L
P
C
Y
---
F
E
N
L
L
---
S
-------
H
----
F
L
P
---
Q
---
K
---
A
P
D
--
G
K
--
S
Y
L
L
S
L
P
---
T
---
G
D
V
P
M
D
G
M
S
V
S
D
L
G
P
V
V
L
S
L
L
K
M
--
P
E
--
K
Y
-
V
G
Q
N
----
I
G
--
L
-
S
-
T
-
C
-
R
-
H
T
A
E
E
Y
A
A
L
L
T
K
H
T
R
K
V
V
---
H
D
A
K
M
T
P
E
D
Y
E
-------------
K
L
G
F
P
G
--
A
R
D
L
A
N
M
F
R
F
Y
A
L
R
P
---
D
---
R
----
D
I
E
L
T
-
L
R
L
N
-
P
K
-
A
-
L
T
------------
L
D
Q
W
L
E
Q
H
K
G
DFNL
54
Fugue
68.75
18%
-72
- C2 -
2WMD
2
NMRL1_HUMAN
A:
[5-299]
----------K
K
L
V
V
V
F
G
G
T
G
A
Q
G
G
S
V
A
R
T
L
L
E
D
G
-
T
F
-------
K
V
R
V
V
-
T
R
N
PR
K
K
A
---
A
--
K
---------
E
L
-
R
L
Q
----
G
A
E
V
V
Q
G
D
Q
D
D
Q
V
I
M
E
L
A
L
N
G
A
Y
A
T
F
I
V
T
N
--
Y
W
-------------
E
----
S
C
S
---
Q
-
E
Q
-------------
E
V
K
Q
G
K
L
L
A
D
L
A
R
R
L
G
-
L
H
Y
V
V
Y
S
G
L
E
N
I
K
-
K
-------------
L
------------------
T
A
GRLAA
A
H
F
D
G
K
G
E
--
V
E
E
Y
F
R
D
----
I
G
-------
V
P
M
T
S
V
R
L
P
C
Y
---
F
E
N
-
L
---
L
-------
S
----
H
F
L
---
P
---
Q
---
K
A
P
D-
G
K
--
S
Y
L
---
L
SLP
T
---
G
D
V
P
M
D
G
M
S
V
S
D
L
G
P
V
V
L
S
L
L
K
M
--
P
E
KY
V
G
-
Q
--
N
----
I
G
--
L
-
S
-
T
-
C
-
R
-
H
T
A
E
E
Y
A
A
L
L
T
K
H
T
R
K
V
V
---
H
D
A
K
M
T
P
E
D
Y
E
------
K
L
G
------
F
P
G
A
--
R
D
L
A
N
M
F
R
F
Y
A
L
R
P
D
---
R
D
--------
I
E
L
T
-
L
R
L
N
-
P
K
-
A
-
L
T
------------
L
D
Q
W
L
E
Q
H
K
G
DFNL
43
HHSearch
68.06
20%
-67
- C2 -
3WJ7
2
?
A:
[14-332]
-----------
D
V
T
L
V
T
G
A
T
G
F
V
G
S
A
V
A
R
V
L
E
E
R
G
---
H
------
R
L
R
L
L
-
V
R
P
--
T
S
D
---
R
--
S
---------
N
I
-
A
E
L
----
N
A
E
L
A
V
G
D
L
S
D
P
D
T
L
A
P
A
L
K
G
V
K
I
L
F
H
V
A
A
--
D
Y
RLWVPD
P
E
T
M
M
--
K
----
A
N
V
---
E
-
G
T
-------------
R
-----
N
L
M
L
A
A
L
E
A
G
-
V
E
K
I
I
Y
C
S
S
V
A
A
L
G
L
-------------
R
SDGVPADETTPVSESQV-
I
G
-----
I
Y
K
L
S
K
Y
R
--
A
E
Q
E
V
L
R
L
I
R
E
K
N
-------
L
P
A
I
I
V
N
P
S
T
P
---
V
G
P
-
R
---
D
-------
I
KPT
P
T
G
Q
---
M
---
I
---
L
D
C
--
A
S
--
G
N
M
---
P
---
A
Y
--
V
E
T
G
L
N
I
V
H
V
D
D
V
A
E
G
H
A
L
A
L
E
R
--
G
K
--
I
G
-
E
--
K
----
Y
I
--
L
-
G
-
G
-
E
-
N
-
I
M
L
G
D
L
F
R
M
V
S
Q
I
A
G
V
K
P
---
P
A
V
K
L
K
Q
S
W
L
Y
P
V
A
L
V
S
E
W
L
A
R
G
F
G
I
E
P
R
V
--
T
R
E
T
L
A
---
M
-
S
K
K
L
---
M
F
F
-
S
----
S
D
K
A
K
-
K
E
L
G
-
Y
A
-
P
-
R
P
------------
A
R
D
A
V
T
D
A
I
-----
59
Fugue
67.81
18%
-68
- C2 -
2GN4
3
PSEB_HELPY
A:
[16-344]
-----QNMLDN
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
-
N
A
K
------
K
I
I
V
Y
-
S
R
D
--
E
L
K
---
Q
--
S
---------
E
M
-
A
M
E
F
NDP
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
I
C
I
H
A
A
A
--
L
K
-------------
H
----
V
P
I
---
A
-
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
-----
N
V
I
N
A
C
L
K
N
A
-
I
S
Q
V
I
A
L
S
T
D
K
A
A
-
N
-------------
P
------------------
I
N
-----
L
Y
G
A
T
K
L
C
--
S
D
K
L
F
V
S
----
A
N
NFKGS
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
---
V
G
S
-
R
GS
V
V
-------
P
----
F
F
K
---
K
---
L
---
V
Q
N
KA
S
E
--
I
P
I
---
T
---
D
---
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
--
M
H
--
G
G
-
E
--
I
----
F
V
--
P
-
K
-
I
-
P
-
S
-
M
K
M
T
D
L
A
K
A
L
A
P
N
T
P
T
K
I
---
I
G
I
R
P
G
E
K
L
H
E
------
V
M
I
P
-
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
T
I
S
F
Q
T
P
---
K
D
Y
-
T
----
L
T
K
L
H
-
E
K
G
Q
-
K
V
-
A
-
P
D
FEYSSHNNN
Q
W
L
E
P
D
D
L
L
K
L
L
-----
33
HHSearch
67.75
18%
-69
* C2 *
2WM3
6
NMRL1_HUMAN
A:
[6-294]
-----------
K
L
V
V
V
F
G
G
T
G
A
Q
G
G
S
V
A
R
T
L
L
E
D
G
-
T
F
-------
K
V
R
V
V
-
T
R
N
--
P
R
K
---
K
--
A
A
K
-------
E
L
-
R
L
Q
----
G
A
E
V
V
Q
G
D
Q
D
D
Q
V
I
M
E
L
A
L
N
G
A
Y
A
T
F
I
V
T
N
--
Y
W
ESCS
Q
--------
E
----
Q
E
V
---
K
-
Q
G
-------------
K
-----
L
L
A
D
L
A
R
R
L
G
-
L
H
Y
V
V
Y
S
G
L
E
N
I
K
K
L
-------------
T
A
GRL--------------
A
A
-----
A
H
F
D
G
K
G
E
--
V
E
E
Y
F
R
D
----
I
G
-------
V
P
M
T
S
V
R
L
P
C
Y
---
F
E
N
-
L
---
L
S------
H
----
F
L
P
---
Q
---
K
---
A
P
D
--
G
K
S
Y
L
L
S
---
L
---
P
T--
G
D
V
P
M
D
G
M
S
V
S
D
L
G
P
V
V
L
S
L
L
K
M
PE
K
Y
--
V
G
-
Q
--
N
----
I
G
--
L
-
S
-
T
-
C
-
R
-
H
T
A
E
E
Y
A
A
L
L
T
K
H
T
R
K
V
V
---
H
D
A
K
M
T
P
E
D
Y
E
------
K
L
G
-----
F
P
G
----
A
R
D
L
A
N
M
F
R
F
Y
A
L
R
P
----
D
--
R
----
D
I
E
L
T
-
L
R
L
N
-
P
K
-
A
-
L
T
------------
L
D
Q
W
L
E
Q
H
K
-----
35
HHSearch
67.22
16%
-73
- C2 -
2R6J
1
EGS1_OCIBA
A:
[12-308]
-----------
S
K
I
L
I
F
G
G
T
G
Y
I
G
N
H
M
V
K
G
S
L
K
L
G
---
H
------
P
T
Y
V
F
-
T
R
P
--
N
S
S
---
K
--
T
T
L
L
D
-----
E
F
-
Q
S
L
----
G
A
I
I
V
K
G
E
L
D
E
H
E
K
L
V
E
L
M
K
K
V
D
V
V
I
S
A
L
A
--
F
P
-------------------
Q
I
---
L
-
D
Q
-------------
F
-----
K
I
L
E
A
I
K
V
A
G
N
I
K
R
F
L
P
-
S
D
F
G
V
E
E
D
R
I
N
A
L
P
-------
P
------------------
F
E
-----
A
L
I
E
R
K
R
M
--
I
R
R
A
I
E
E
----
A
N
-------
I
P
Y
T
Y
V
S
A
N
C
F
---
A
S
Y
-
F
I
--
N
-------
Y
----
L
L
R
---
P
---
Y
---
D
P
K
--
D
E
--
I
T
V
---
Y
---
G
T--
G
E
A
K
F
A
M
N
Y
E
Q
D
I
G
L
Y
T
I
K
V
A
T
D
P-
R
A
--
L
N
-
R
--
V
V
---
I
Y
--
R
-
P
-
S
-
T
-
N
I
I
T
Q
L
E
L
I
S
R
W
E
K
K
I
G
K
K
F
---
K
K
I
H
V
P
E
E
E
I
V
------
A
L
T
K
-
E
--
L
P
E
P
E
--
N
I
P
I
A
I
L
H
C
L
F
I
D
G
A
TMS
Y
D
F
K
E
ND--
V
E
A
S
T
-
L
Y
P
E
-
L
K
-
F
-
T
T
------------
I
D
E
L
L
D
I
F
V
H
----
42
HHSearch
66.15
19%
-70
- C2 -
1R6D
2
?
A:
[1-308]
-----------
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
---
Y
PDVPAD
E
V
I
V
L
-
D
S
L
--
T
Y
A
GNR
A
NL
A
---------
P
V
D
A
D
P
----
R
L
R
F
V
H
G
D
I
R
D
A
G
L
L
A
R
E
L
R
G
V
D
A
I
V
H
F
A
A
--
E
S
H
V
D
R
S
I
A
GA
S
V
F
T
E
----
T
N
V
---
Q
-
G
T
-------------
Q
-----
T
L
L
Q
C
A
V
D
A
G
-
V
G
R
V
V
H
V
S
T
N
Q
V
Y
G
S
ID
S
G
S
W
T
ESSPLE
P
------------------
N
S
-----
P
Y
A
A
S
K
A
G
--
S
D
L
V
A
R
A
Y
H
R
T
Y
G
-------
L
D
V
R
I
T
R
C
C
N
N
---
Y
G
P
-
Y
---
Q
HPEK
L
I
P
L
----
F
V
T
---
N
---
L
---
L
D
G
--
G
T
--
L
P
L
---
Y
---
G
D--
G
A
N
V
R
E
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
--
G
R
--
A
G
-
E
--
I
----
Y
H
--
I
-
G
-
G
-
G
-
L
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
W
---
S
S
V
R
----
K
V
A
-------------
D
R
K
G
---------------
H
D
L
R
---
Y
S
L
-
D
----
G
G
K
I
E
-
R
E
L
G
-
Y
R
-
P
Q
V
S
------------
F
A
D
G
L
A
R
T
V
-----
39
HHSearch
66.12
17%
-69
- C2 -
2X4G
-
?
A:
[13-330]
-----------
V
K
Y
A
V
L
G
A
T
G
L
L
G
H
H
A
A
R
A
I
R
A
A
G
---
H
------
D
L
V
L
I
-
H
R
P
--
S
S
Q
---
I
--
Q
---------
R
L
-
A
Y
L
----
E
P
E
C
R
V
A
E
M
L
D
H
A
G
L
E
R
A
L
R
G
L
D
G
V
I
F
S
--------------------E
E
V
A
S
A
L
---
G
-
Q
T
-------------
N
-----
P
F
Y
A
A
C
L
Q
A
R
-
V
P
R
I
L
Y
V
G
S
A
Y
A
M
P
R
-------------
H
PQGLPGHEGLFYDSLPSG
K
S
-----
S
Y
V
L
C
K
W
A
--
L
D
E
Q
A
R
E
Q
A
R
-
N
G
-------
L
P
V
V
I
G
I
P
G
M
V
---
L
G
E
-
L
---
D
I------
G
P---
T
T
G
---
R
---
V
I
T
A
I
G
N
--
G
E
--
M
T
H
---
Y
-------
V
A
G
Q
R
N
V
I
D
A
A
E
A
G
R
G
L
L
M
A
L
E
R
--
G
R
--
I
G
-
E
--
R
----
Y
L
--
L
-
T
-
G
-
H
-
N
-
L
E
M
A
D
L
T
R
R
I
A
E
L
L
G
Q
P
A
---
P
-
Q
P
M
S
M
A
M
A
R
------
A
L
A
T
-
L
G
R
L
--------------
E
V
M
A
-
G
G
---
Q
F
L
-
D
----
G
R
K
A
R
-
E
E
L
G
-
F
F
S
T
-
T
A
------------
L
D
D
T
L
L
R
A
I
-----