@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0476: (2016-03-15 )
MKMTDPLYGTFEIEPVLAELIQSPLVSRLAHVHQGGSSYLVNPLWDLSRLDHSIGVMLFIRKFGGSLEEQIAGLLHDVSHTAFSHVVDYALDFEEEDYHEQIFEDFVKTSTIPAILEKYGYSFEGIFNDISKWKILEQEAPELCADRIDYTLQDLYRHGKISLAEVKEFLQALVMVDGRLYLANIALAEWFVAQYYSEVIDYFYDPLNVYSYEILAEAMRIAFQQETITTADLRLTDAELLAKLNANSDAREKIQLLASPHLEENEVDFTYHHKKKMRLINPSVLVDGRLIPADELSEKVREMNDWASERSKHGIYIKATKKSKQ
Atome Classification :
(26 SA)
--.........10...-.....20........30........40........50.....----...60.......-------------.-----------70........80.......---.90.......-.100---........110....---------...120....--.--..-----130---.........--------140.......150.......-160-.......170.......180---.--..---....190.......200.......210.......220....----------------------------...230--..-.....240......---.-250-----------......-------------.-260-.-..-----------.--------------------....270....-.---..280..----------..-...290.......300.......310.......320...-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MKMTDPL
Y
G
T
F
E
I
E
-
P
V
L
A
E
L
I
Q
S
P
L
V
S
R
L
A
H
V
HQGGS
S
Y
L
VNP
L
W
D
L
S
R
L
D
H
S
I
G
V
----
M
L
F
I
R
K
FGG
S
L
E
-------------
E
-----------
Q
I
A
G
L
L
H
D
V
S
H
T
A
F
S
H
V
V
D
---
Y
ALDFEE
E
D
Y
-
H
E
Q
----
I
F
E
D
F
V
KTS
T
I
P
A
I
L
---------
E
KYGY
S
F
E
G
I
--F--ND-----
I
-----
S
K
W
K
I
L
E
QE--------
A
P
E
L
C
A
D
R
I
D
Y
T
L
Q
D
L
Y
R
HG-KI
S
-
L
A
E
V
K
E
F
L
Q
A
L
V
MVDG
R
L
Y
L
---
A
--
N
I
---
A
L
A
E
W
F
V
A
Q
Y
Y
S
E
V
I
D
Y
FY
D
P
L
N
V
Y
S
Y
E
I
L
A
E
A
M
R
I
A
F
QQE----------------------------TITTAD--
L
R
-LT
D
A
E
L
L
A
K
LNAN
S
---
D
-
A
R
E
-----------
K
I
Q
L
L
A-------------S-PH--L-EE-----------N--------------------EV
D
F
T
Y
HH
K
K
K
-
M
---
R
LIN
P
S
V
----------
L
V-DGRLI
P
A
D
E
L
S
E
K
V
R
E
M
N
D
W
A
S
ERSKH
G
I
Y
I
K
ATKKSKQ-----
64
Fugue
96.20
26%
-89
- C9 -
2HEK
13
?
A:
[1-369]
M
I
K
E
F
S
D
P
L
Y
G
F
V
R
V
G
-
E
A
G
L
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
----
Y
H
I
T
E
R
I
C
E
S
L
K
-------------
V
KE
K
E
L
V
-----
K
L
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
---
V
L
L
P
R
E
R
S
---
H
E
D
----
F
T
E
R
V
I
K
E
T
E
I
Y
E
I
L
K
Q
D
YS
H
E
D
I
E
R
L
V
R
I
T
L
G
K
--
P
--
E
D
-----
E
-----
E
E
K
L
L
S
E
I
I
--------
T
G
E
F
G
S
D
R
M
D
Y
L
R
R
D
A
Y
F
C
G
V
S
Y
G
-
F
F
D
Y
D
R
L
I
S
T
L
R
V
Y
E
N
K
V
V
V
DES
G
--
L
R
---
A
L
E
N
F
L
I
S
R
Y
F
M
Y
V
Q
V
Y
F
H
-
K
V
V
R
I
L
S
I
H
L
V
E
F
L
K
K
L
I
S
Q
E
----------------------------
D
F
T
D
I
N
N
F
L
R
-
L
N
D
A
F
V
I
S
E
L
F
K
R
K
---
A
-
F
R
E
-----------
D
F
E
R
I
F
QRKHFKTLLSTEN
Y
-
E
K
--
F
-
S
E
-----------
T
--------------------
K
E
R
L
L
E
K
F
P
Q
E
-
K
---
V
R
F
D
E
V
E
K
E
VYGGN
I
Y
V
L
S
-
S
E
G
L
K
K
A
H
E
L
S
P
L
I
A
S
L
K
----
P
I
K
L
Y
R
I
Y
V
D
R
Q
L
W
E
K
A
R
S
E
L
K
38
HHSearch
94.39
27%
-87
- C9 -
2HEK
13
?
A:
[3-351]
--
K
E
F
S
D
P
L
Y
G
F
V
R
V
G
-
E
A
G
L
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
----
Y
H
I
T
E
R
I
C
E
S
L
K
-------------
V
KE
K
E
L
V
-----
K
L
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
---
V
L
L
P
R
--
E
R
S
-
H
E
D
----
F
T
E
R
V
I
K
E
T
E
I
Y
E
I
L
---------
K
Q
-
D
Y
S
H
E
D
I
--
E
R
L
V
R
I
T
L
--
G
KPED
E
E
E
K
L
L
S
E
I
I
--------
T
G
E
F
G
S
D
R
M
D
Y
L
R
R
D
A
Y
F
C
G
-
V
S
Y
G
F
F
D
Y
D
R
L
I
S
T
L
R
V
Y
E
N
K
V
V
V
---
D
--
E
S
G
L
-
R
A
L
E
N
F
L
I
S
R
Y
F
M
Y
V
Q
V
Y
F
H
K
V
V
R
I
L
S
I
H
L
V
E
F
L
K
K
L
I
S
Q
E
D---------------------------
F
T
D
I
N
N
--
F
L
R
L
N
D
A
F
V
I
S
E
L
F
K
R
K
---
A
F
R
E
D
F
E
R
I
FQRK---
H
F
K
T
L
L
-------------
S
T
E
N
Y
E
K
F
S
E
T
K
E
R
L
L
E
K
FPQ
E
--------------------
K
V
R
F
D
E
V
E
K
E
--
V
---
Y
G
G
N
I
Y
V
----------
L
S
-
S
E
G
L
K
K
A
H
E
L
S
P
L
I
A
S
L
K
P
I
K
L
----------------------
1
PsiBlast_PDB
92.29
28%
-102
- C8 -
2HEK
12
?
A:
[4-275]
---
E
F
S
D
P
L
Y
G
F
V
R
V
G
-
E
A
G
L
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
----
Y
H
I
T
E
R
I
C
E
S
L
K
VKE
K
E
L
-------
V
-----------
K
L
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
---
V
L
L
P
--
R
E
R
S
-
H
E
D
----
F
T
E
R
V
I
K
E
T
E
I
Y
E
I
L
----------
K
Q
D
Y
S
H
E
D
I
E
R
L
--
V
R
-----
I
-----
T
L
G
K
P
E
D
E
E
E
K
L
L
S
E
I
I
T
G
E
F
G
S
D
R
M
D
Y
L
R
R
D
A
Y
F
C
G
V
S
Y
G
-
F
F
D
Y
D
R
L
I
S
T
L
R
V
Y
E
N
K
V
V
V
---
D
--
E
S
G
L
R
A
L
E
N
F
L
I
S
R
Y
F
M
Y
V
Q
V
Y
F
H
K
V
V
R
I
L
S
I
H
-
L
V
E
F
L
K
K
L
I
S
Q
E
----------------------------
D
F
T
D
I
N
N
F
L
R
-
L
N
D
A
F
V
I
S
E
L
F
K
R
K
---
A
-
F
R
E
-----------
D
F
E
------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
82.34
21%
-76
* C9 *
2Q14
6
?
A:
[7-397]
--
K
I
I
N
D
P
V
F
G
F
I
N
I
P
K
G
L
L
Y
D
I
V
R
H
P
L
L
Q
R
L
T
R
I
K
Q
V
G
L
S
S
V
V
Y
P
G
A
Q
H
T
R
F
Q
H
S
L
G
A
----
F
Y
L
M
S
E
A
I
T
Q
L
T
S
K
G
N
F
I
F
D
S
E
A
E
A
V
-----------
Q
A
A
I
L
L
H
D
I
G
H
G
P
F
S
H
V
L
E
---
D
T
I
V
Q
--
G
V
S
-
H
E
E
----
I
S
L
M
L
M
E
R
M
-----
N
---------
K
E
M
N
G
Q
L
S
L
A
-----
I
Q
I
F
K
DE
Y
-----
P
K
R
F
L
H
Q
L
V
--------
S
G
Q
L
D
M
D
R
L
D
Y
L
R
R
D
S
F
Y
T
G
-
V
T
E
G
N
I
G
S
A
R
I
I
K
M
L
D
V
A
D
D
R
L
V
I
---
E
SK
G
I
---
Y
S
I
E
N
F
L
T
A
R
R
L
M
Y
W
Q
V
Y
L
H
K
T
S
V
A
Y
E
R
M
L
I
S
T
L
L
R
A
K
E
L
A
S
Q
G
V
E
L
F
A
S
P
A
L
H
F
F
L
Y
N
DIN
H
T
E
F
H
N
N
P
D
C
L
E
N
--
F
I
Q
L
D
D
N
D
I
W
T
A
L
K
V
W
S
NHP
D
-
K
V
L
S
T
L
S
L
G
M
I
N
RN
I
F
K
V
E
N
-------------
S
A
E
P
--
I
-
G
E
-----------
D
R
I
K
E
L
T
L
Q
I
S
Q
Q
L
GITLSEA
N
Y
F
V
S
T
P
S
I
E
K
N
M
YDP
A
D
D
S
I
D
I
----------
I
Y
K
D
G
T
I
K
N
I
A
E
A
S
D
M
L
N
I
S
L
L
S
K
K
----------------------
32
PsiBlast_CBE
69.05
31%
-93
- C8 -
4RXO
4
SAMH1_HUMAN
C:
[31-207]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
68.73
31%
-92
- C8 -
4BZC
6
SAMH1_HUMAN
A:
[42-192]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
68.57
31%
-94
- C8 -
4BZC
6
SAMH1_HUMAN
B:
[42-192]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
68.52
31%
-92
- C8 -
4RXO
4
SAMH1_HUMAN
B:
[31-208]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.41
31%
-97
- C8 -
4MZ7
6
SAMH1_HUMAN
A:
[31-177]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
68.33
31%
-96
- C8 -
4Q7H
2
SAMH1_HUMAN
C:
[18-181]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
68.22
31%
-93
- C8 -
4RXO
4
SAMH1_HUMAN
D:
[31-197]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
GYLA
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQISERDVLCV
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
GSVM
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
68.21
31%
-94
- C8 -
4Q7H
3
SAMH1_HUMAN
B:
[18-179]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
68.18
31%
-97
- C8 -
4RXS
5
SAMH1_HUMAN
B:
[31-177]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.88
30%
-95
- C8 -
4TNQ
5
SAMH1_HUMAN
A:
[6-151]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.87
30%
-90
- C8 -
4TNX
5
SAMH1_HUMAN
A:
[6-152]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
67.86
31%
-91
- C8 -
4BZC
6
SAMH1_HUMAN
C:
[42-188]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
67.84
31%
-93
- C8 -
4BZC
6
SAMH1_HUMAN
D:
[42-199]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.82
31%
-91
- C8 -
4RXO
4
SAMH1_HUMAN
A:
[31-185]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.52
31%
-99
- C8 -
4RXP
5
SAMH1_HUMAN
A:
[31-176]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
67.47
31%
-97
- C8 -
4MZ7
6
SAMH1_HUMAN
B:
[31-176]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.36
31%
-97
- C8 -
4RXS
5
SAMH1_HUMAN
A:
[31-177]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
67.31
31%
-100
- C8 -
4RXQ
5
SAMH1_HUMAN
B:
[31-176]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
67.20
31%
-98
- C8 -
4RXP
5
SAMH1_HUMAN
B:
[31-176]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
67.18
31%
-100
- C8 -
4RXR
5
SAMH1_HUMAN
B:
[31-176]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.14
31%
-100
- C8 -
4RXQ
5
SAMH1_HUMAN
A:
[31-176]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.88
31%
-99
- C8 -
4RXR
5
SAMH1_HUMAN
A:
[31-176]
----
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
K
Q
P
-------------
E
LQIS
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRF
I
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
I
K
P
V
M
---------
E
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------