@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0540: (2016-03-16 )
MNRRERRKHKRRKNMIIVLSTVFLMFIATSWMIYEFKSKQEQTVSAPTKKKAATATNPSENAATNEPEETKDPEPVEEKPKETIVKNQEIDNYLQKIGFSGSALVVRDGETIIQKGYMYANRDDKVLNTPDTLFYIGSSQKAIIATALLQLEEKGKINTNDPISKYIPDFPNGNKILVKNFMNHTSGIVGRPNLTSNMTPDQIVKAIEKRGIKSQPGKWDYMDANYTVVGYLVEKISGQPLATYLQENIFNPAGMKHTGYYQKDVDGGKNVSTGYKIDENGVFQSPKLADLTKLYGAGDISMSTTDMYLFDKALMDKKLISEASLKKMFTKGSKSTYGMGFYVDPGSYNSHGVVTGWDVSNSFSHTGRTYVILFSNVQNYIASFGKVNNDIYGFLNK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.-......110.......120.......130.......140.......150.......160.......170.--.------.......180......-------------.190.-..----------------.-----------...200----------.........--210.--....-..220.......230.......240.......250.......260.......270.....-.-.-------------280..------------...-..290.-----......300.......310....--.--..320......---.330-------.--------......340-----...-------.-----...350..--..-...360.......370.......380.......390.....----------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
R
R
E
R
R
K
H
K
RRK
N
M
I
I
V
L
S
T
V
F
L
M
F
I
A
T
S
W
M
I
Y
E
FKSKQEQTVSAPTKKKAATATNPSENAATNEPEETKDPEPVEEK
P
K
E
T
I
V
K
N
Q
E
I
D
N
Y
L
Q
K
IGFSG
S
A
-
L
V
V
RD
G
E
T
I
I
QK
G
Y
M
YANRDDKVLNTPD
T
L
F
Y
IGSS
Q
K
A
I
I
A
T
A
L
L
Q
L
E
EKGKINTND
P
I
S
K
YIPDF--P--N------G
N
K
I
L
V
K
N
F
M
N
HTSGI-------------VGRPN-LT----------------S-----------NM
T
P
------------
D
Q
I
V
K
A
I
E
K--RGIK--SQPG-K
W
D
YMDAN
Y
T
V
V
G
Y
L
V
E
K
ISG
Q
P
L
A
T
Y
L
Q
E
NIFNPAGMKHTG
Y
Y
QKDVDGGKNVSTG
Y
K
I-D-E-------------NGVFQ------------SP
K
-
L
A
D
L
T
K
-----
L
YGAGDISMST
T
D
M
Y
L
F
D
K
A
L
M
D
--
K
--
K
L
I
S
E
A
S
L
K
K
M
---
F
TKG-------S--------KST
Y
G
M
G
F
Y
-----VDP-------G-----SYNSH
G
V
V
--
T
G-WDVSNSFSHTG
R
T
Y
V
I
L
FS
N
V
Q
N
Y
I
A
S
FGKVNN
D
I
Y
GFLNK----------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
88.63
28%
-76
- C2 -
1CEF
1
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
VRN
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
88.36
28%
-73
- C2 -
1PW1
6
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
VRN
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
88.25
28%
-74
- C2 -
1YQS
4
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
88.09
28%
-72
- C2 -
1PW8
3
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
VRN
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.05
28%
-71
- C2 -
1IKI
2
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
87.99
28%
-72
- C2 -
1PWG
1
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.89
28%
-72
- C2 -
1PWC
1
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
87.82
28%
-71
- C2 -
1IKG
1
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
VRN
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.81
28%
-70
- C2 -
1SCW
6
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
VRN
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
87.79
28%
-72
- C2 -
1CEG
1
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
VRN
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
66
Fugue
87.75
23%
-58
- C2 -
2QMI
-
?
A:
[1-447]
--------------------------------------
M
D
V
G
K
L
E
S
F
I
V
E
K
M
A
E
R
K
V
P
-----------------------------------------
G
I
S
I
-
S
I
I
K
D
G
D
V
V
Y
A
K
G
F
G
Y
R
N
V
E
A
R
L
P
S
T
P
E
T
I
Y
G
I
G
S
I
T
K
S
F
T
A
L
A
I
M
K
L
V
E
E
G
G
L
S
L
D
D
P
V
E
K
F
V
N
I
K
--
L
RP
F
------
G
E
P
V
T
V
H
H
L
L
T
H
S
S
G
I
PSLG
Y
A
E
A
F
I
D
G
M
V
G
G
D
N
-
W
L
----------------
P
-----------
V
S
T
P
------------
E
E
T
I
A
F
A
R
D
--
M
E
K
W
AV
A
K
P
G
E
R
F
F
Y
L
N
T
G
Y
V
L
L
G
K
I
I
E
K
V
S
G
V
S
Y
E
E
Y
I
K
K
K
I
L
E
P
L
G
M
N
R
S
Y
F
F
K
E
E
V
E
K
D
K
D
V
A
M
G
Y
I
L
-
D
-
K
-------------
E
G
R
L
V
------------
P
Q
P
-
F
--
P
Y
G
-----
I
T
A
D
G
G
L
L
S
S
V
L
D
L
A
K
Y
L
K
M
Y
I
E
RD
E
--
S
I
V
S
K
E
Y
I
E
K
M
---
E
T
S
Y
-------
I
KVPWEIFG
G
E
G
Y
G
Y
G
L
I
-----
I
Y
P
-------
N
FLG
E
K
L
V
G
H
S
G
S
V
--
G
M
-
Y
T
G
Y
I
G
Y
I
P
E
K
K
I
G
V
A
V
L
E
N
S
S
G
--
Y
P
P
S
Y
I
A
M
Y
A
L
A
L
L
L
G
KNPEKELPFI
Y
R
E
R
I
L
K
K
V
E
G
R
Y
M
G
YKGT
I
K
F
E
V
K
V
D
GD
V
V
Y
L
R
A
L
G
RA
F
T
Y
T
I
P
L
F
P
EVLEED
F
I
K
C
Y
T
L
S
NG
R
K
M
Y
A
E
F
Y
I
K
DN
K
V
D
L
I
F
ER
Y
R
L
I
K
S
42
HHSearch
87.66
26%
-60
- C2 -
1YQS
4
DAC_STRSR
A:
[6-344]
--------------------------------------------------------------------------------
P
D
D
T
G
L
Q
A
V
L
H
T
A
L
S
-
Q
G
A
P
G
A
M
V
R
V
D
D
N
G
T
-
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
-
D
M
F
A
QT
V
P
G
F
E
S
V
R
N---
K
-----------
V
F
S
Y
------------
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
-
P
-
D
EAG----------
G
A
L
V
-------------
D
S
T
-
E
Q
T
V
S
W
-----
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
---
Q
Q
W
T
TVN----
S
--------
T
Q
G
Y
G
L
G
L
R
-----
R
R
D
L
SCG
I
--
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
M
A
R
T
L
E
S
A
F
C
-----------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.65
28%
-70
- C2 -
1SDE
1
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
87.59
28%
-71
- C2 -
1PWD
1
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
43
HHSearch
87.51
24%
-78
- C2 -
3TG9
-
?
A:
[1-318]
-------------------------------------------------------------------------------------
M
K
N
H
L
H
T
I
M
E
D
W
K
L
S
G
T
A
-
L
M
K
K
G
E
D
I
P
F
I
A
S
L
G
F
A
N
R
A
E
R
I
P
N
E
H
H
T
R
F
G
I
A
S
G
C
K
L
F
T
A
I
A
I
C
Q
L
V
E
A
G
K
L
S
F
D
T
P
L
S
D
W
L
D
A
P
------------
F
P
N
V
T
I
H
H
L
L
T
H
T
S
G
V
-------------
P
D
Y
F
D
--------------------EDLWKDVPMYH
L
R
R
L
------------
K
D
F
L
P
L
F
Q
H
--
A
P
M
K
--
F
P
P
G
H
R
F
H
Y
N
N
A
G
F
I
L
L
G
L
V
V
E
S
V
S
G
V
T
F
Q
E
Y
V
E
A
N
V
F
Q
R
A
G
M
H
E
S
G
Y
F
A
F
D
T
-
L
P
A
K
T
A
L
G
Y
I
D
-
L
-
E
-------------
D
G
S
W
K
------------
T
N
L
-
Y
S
L
P
V
I
-----
G
G
S
D
G
G
A
Y
V
T
A
E
D
M
M
K
L
W
L
A
L
M
R
--
H
--
E
L
L
N
E
T
Y
T
Q
K
L
---
L
T
P
H
VHCE---
D
--------
D
D
Y
Y
G
Y
G
V
W
-----
I
K
Q
Q
DGAI--
S
-----
K
Y
H
V
M
G
Y
D
--
P
G
-
V
C
F
H
S
A
F
Y
P
T
S
N
G
I
V
V
V
C
A
N
Q
S
S
G
A
--------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
87.50
28%
-71
- C2 -
3PTE
-
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
VRN
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.07
28%
-70
- C2 -
1MPL
5
DAC_STRSR
A:
[22-329]
-------------------------------------------------------------------------------------------------
G
A
P
G
A
M
-
V
R
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
L
P
G
L
--
L
--
P
------
D
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
-------------
Y
D
Y
T
N
D
M
F
----------------
A
-----------
Q
T
V
P
G
F
E
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
L
K
--
H
G
V
T
--
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
I
P
G
T
H
A
N
G
Y
L
T
P
D
-
E
-------------
A
G
----------------
G
A
-
L
V
D
S
T
E
QTVSW
A
Q
S
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
--
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
QW
T
T
V
N
-------
S
--------
T
Q
G
Y
G
L
G
L
R
R
R
D
L
S
C
G
I
-------
S
-----
V
Y
G
H
T
G
T
V
--
Q
G
-
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
--------------------------------------------------------------------------------------------------------------------
45
HHSearch
82.46
23%
-63
- C2 -
2DRW
4
?
A:
[5-338]
----------------------------------------------------------------------------------
N
N
A
I
Q
G
I
L
D
D
H
V
A
-
R
G
V
V
G
V
S
L
A
L
C
L
P
G
E
E
T
S
L
Y
Q
S
G
Y
A
D
K
F
N
K
M
P
M
T
G
D
H
L
F
R
I
A
S
C
T
K
S
F
I
A
T
G
L
H
L
L
V
Q
D
G
T
V
D
L
D
E
P
I
T
R
W
F
P
D
L
--
P
--
K
------
A
A
Q
M
P
V
R
I
L
L
N
H
R
S
G
L
-------------
P
D
F
E
T
-
S
M
PMISD-----------
K
-----------
S
W
T
A
------------
Q
E
I
V
D
F
S
F
R
--
H
G
V
Q
--
K
E
P
W
H
G
M
E
Y
S
N
T
G
Y
V
L
A
G
M
I
I
A
H
E
T
G
K
P
Y
S
D
H
L
R
S
R
I
F
A
P
L
G
M
K
D
T
W
V
G
T
H
E
T
F
P
I
E
R
E
A
R
G
Y
M
H
-
A
-
A
ADDENPQWDVSGA
G
D
P
V
D
GVWD--------
S
T
E
-
W
F
P
L
S
G
-----
A
N
A
A
G
D
M
V
S
T
P
R
D
I
V
K
F
L
N
A
L
F
D
--
G
--
R
I
L
D
Q
K
R
L
W
E
M
---
K
D
N
I
-------
K
P
A
F
F
P
GSN
T
V
A
N
G
H
G
L
L
-----
L
M
R
YGSS---
E
-----
L
K
G
H
L
G
Q
I
--
P
G
-
H
T
S
I
M
G
R
D
E
E
T
G
A
A
L
M
L
I
Q
N
S
G
A
G
D
--------------------------------------------------------------------------------------------------------------------
50
HHSearch
80.96
20%
-67
- C2 -
1CI9
1
ESTB_BURGA
A:
[17-387]
--------------------------------------------------------------------------------
S
L
A
A
R
L
D
A
V
F
D
Q
A
L
R
E
R
R
L
V
G
A
V
A
I
V
A
R
H
G
E
I
L
Y
R
R
A
Q
G
L
A
D
R
E
A
G
R
P
M
R
E
D
T
L
F
R
L
A
S
V
T
K
P
I
V
A
L
A
V
L
R
L
V
A
R
G
E
L
A
L
D
A
P
V
T
R
W
L
P
E
F
--
R
--
P
R
L
ADGS
E
P
L
V
T
I
H
H
L
L
T
H
T
S
G
L
-------------
G
Y
W
L
L
-
E
G
AGS
V
Y
D
R
L
GISDGIDL
R
-----------
D
F
D
L
------------
D
E
N
L
R
R
L
A
S
--
A
P
L
S
--
F
A
P
G
S
G
W
Q
Y
S
L
-
A
L
D
V
L
G
A
V
V
E
R
A
T
G
Q
P
L
A
A
A
V
D
A
L
V
A
Q
P
L
G
M
R
D
C
G
F
V
S
A
E
P
---
E
R
F
A
V
P
Y
H
D
-
G
-
Q
P
E
P
V
R
M
R
D
-----
G
I
E
V
P
L
P
EGHGA
A
V
R
F
A
P
S
R
V
F
E
P
G
A
Y
-----
P
S
G
G
A
G
M
Y
G
S
A
D
D
V
L
R
A
L
E
A
I
R
A
--
N
--
P
G
F
L
P
E
T
L
A
D
A
A
--
R
R
D
Q
AGVGAET
R
--------
G
P
G
W
G
F
G
Y
L
-----
S
A
V
LDDPAAA
G
-----
T
P
Q
H
A
G
T
L
Q
W
G
G
V
Y
G
H
S
W
F
V
D
R
A
L
G
L
S
V
L
L
L
T
N
T
A
Y
E
G
M
-
S
G
P
L
T
I
A
L
R
D
--------------------------------------------------------------------------------------------------------
39
HHSearch
80.37
24%
-65
* C2 *
2QMI
-
?
A:
[3-332]
----------------------------------------------------------------------------------
V
G
K
L
E
S
F
I
V
E
K
M
A
E
R
K
V
P
G
I
S
I
S
I
I
K
D
G
D
V
V
Y
A
K
G
F
G
Y
R
N
V
E
A
R
L
P
S
T
P
E
T
I
Y
G
I
G
S
I
T
K
S
F
T
A
L
A
I
M
K
L
V
E
E
G
G
L
S
L
D
D
P
V
E
K
F
V
N
I
K
LR
P
--
F
------
G
E
P
V
T
V
H
H
L
L
T
H
S
S
G
I
-------------
P
S
L
G
Y
-
A
E
A
F
I
D
G
M
V
GGDNWL---
P
-----------
V
S
T
P
------------
E
E
T
I
A
F
A
R
D
ME
K
W
A
V
--
A
K
P
G
E
R
F
F
Y
L
N
T
G
Y
V
L
L
G
K
I
I
E
K
V
S
G
V
S
Y
E
E
Y
I
K
K
K
I
L
E
P
L
G
M
N
R
S
Y
F
F
K
E
E
V
E
K
D
K
D
V
A
M
G
Y
I
L
-
D
K
E
-------------
G
R
L
---------------
V
P
-
Q
P
F
P
Y
G
-----
I
T
A
D
G
G
L
L
S
S
V
L
D
L
A
K
Y
L
K
M
Y
I
E
--
R
DE
S
I
V
S
K
E
Y
I
E
K
M
---
E
T
S
Y
-------
I
KVPWEIFG
G
E
G
Y
G
Y
G
L
I
-----
I
Y
P
NFLG
E
--
K
-----
L
V
G
H
S
G
S
V
--
G
M
-
Y
T
G
Y
I
G
Y
I
P
E
K
K
I
G
V
A
V
L
E
N
S
S
G
Y
---------------------------------------------------------------------------------------------------------------------