@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0595: (2016-03-17 )
MSNEYKFETIQVHGGHTPDGDTHSRAVPIYQTTSYTFDSPEHAAALFGLQETGNIYTRIMNPTTAVLEERLTLLEGGIGAVATASGMAAITYSILNIAGSGDHIVAAATLYGGTHTLFSHTFKTFGIDVTFVDPNEPENFEKAIKDNTKAVFIETIGNPDINIVDIEKVAKIAHASDIPLIVDNTFATAYLNRPFDFGADIVVYSATKFIGGHGVAIGGAVIDSGKFNWANGKFPKLVVPDDSYNGLSYTNDVGAAAYITKLRVSLLRDTGAALSPFNAFLLILGLETLSLRLEQHVKNAKQVANFLNDHPKVAWVNYPGLKDNKYHELAQKYLPKGPGSIFTFGVKGGYEAGKKVIESVELFSHLANVGDAKSLIIHPASTTHQQLSEEQQLTAGVKPESIRLSIGIENADDIIQDLTKALEQI
Atome Classification :
(28 SA)
.........10........20.......-.30........40........50........60........70........80........90........100.......110.......120.......130.-..-.-...140.......150.......160.......170...-.-.-..180.......-190.......200.......210.-.......220......---.230.......240.......250.......260..-.-....-270.......280.......290.......300.......310.......320.......330.......340........350.......360.......370.......380.......390.......400.......410.......420...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSN
E
Y
K
F
E
T
I
Q
V
HGGHTPDGDTH
S
R
A
V
P
-
I
Y
Q
T
T
S
Y
TFDSP
E
H
A
A
A
L
FGLQETG
N
I
Y
T
RIMN
P
T
T
A
V
L
E
E
R
L
T
L
L
EGGIG
A
V
ATAS
G
M
A
A
I
T
Y
S
I
L
NIAGSGD
H
I
V
A
A
A
T
LYGG
T
H
T
L
F
S
H
T
F
K
TF
G
I
D
V
T
F
VD-PN-E-
P
E
N
F
E
K
A
I
KDNT
K
A
V
F
I
E
TIGNPD
I
N
I
V
D
I
E
K
V
A
K
I
AHA-S-D-I
P
L
I
VDNT
F
A
T
A
-YLNRPFDFGA
D
I
V
V
Y
S
A
T
KFIG-G-H
G
V
A
IG
G
A
V
IDSGKFN---WANGKF
P
K
L
VVPDDSYNGLSYTNDV
G
A
A
A
Y
I
T
K
L
R
V
-
S
-
L
L
RD-TGAAL
S
P
F
N
A
F
L
L
I
L
G
L
E
T
L
S
L
R
L
E
Q
H
V
K
N
A
K
Q
V
A
N
F
L
NDHP
K
V
A
W
V
NYPGLKD
N
K
Y
H
E
L
A
Q
K
YLPKGPG
S
-
I
F
T
F
GVKG
G
Y
E
A
G
K
K
V
I
E
S
V
E
L
F
S
H
L
A
NVGDA
K
S
L
I
I
HPAS
T
T
H
Q
Q
L
S
E
E
Q
Q
L
TAGVKP
E
S
I
R
L
S
IGIE
N
A
D
D
I
I
Q
D
L
T
K
A
L
E
QI
29
PsiBlast_CBE
92.73
46%
-98
- C1 -
4OC9
1
?
B:
[7-423]
-------
E
T
L
A
L
H
G
A
Y
N
F
D
T
Q
-
R
S
I
S
V
P
-
I
Y
Q
N
T
A
Y
N
F
E
N
L
D
Q
A
A
A
R
F
N
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
S
D
V
L
G
Q
R
L
A
N
V
E
G
G
A
F
G
I
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
S
H
T
L
K
N
F
G
I
E
A
R
E
F
D
-
I
D
-
D
-
L
D
S
L
E
K
V
I
D
Q
N
T
K
A
I
F
F
E
S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
-
H
-
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
-
G
-
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
D
L
L
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
P
I
F
S
I
R
V
I
I
-
T
-
W
L
R
D
-
L
G
A
S
L
A
P
Q
N
A
W
L
L
L
Q
G
L
E
T
L
A
V
R
I
E
K
H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
A
S
T
T
H
-
Q
L
S
E
E
E
L
Q
K
A
G
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
102
HHSearch
92.68
52%
-99
- C1 -
2CTZ
1
?
A:
[1-421]
----
M
R
F
E
T
L
Q
L
H
A
G
Y
E
P
E
P
T
T
L
S
R
Q
V
P
-
I
Y
P
T
T
S
Y
V
F
K
S
P
E
H
A
A
N
L
F
A
L
K
E
F
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
G
I
E
V
R
F
T
S
-
R
E
E
R
-
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
-
K
-
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
-
G
-
H
G
A
V
I
A
G
A
I
V
D
G
G
N
F
P
---
W
E
G
G
R
Y
P
L
L
T
E
P
Q
P
G
Y
H
G
L
R
L
T
E
A
F
G
E
L
A
F
I
V
K
A
R
V
-
D
-
G
L
R
D
-
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
F
K
G
K
P
G
A
-
V
L
T
F
G
L
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
--
26
PsiBlast_CBE
92.62
46%
-98
- C1 -
4OC9
1
?
G:
[7-423]
-------
E
T
L
A
L
H
G
A
Y
N
F
D
T
Q
-
R
S
I
S
V
P
-
I
Y
Q
N
T
A
Y
N
F
E
N
L
D
Q
A
A
A
R
F
N
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
S
D
V
L
G
Q
R
L
A
N
V
E
G
G
A
F
G
I
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
S
H
T
L
K
N
F
G
I
E
A
R
E
F
D
-
I
D
-
D
-
L
D
S
L
E
K
V
I
D
Q
N
T
K
A
I
F
F
E
S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
-
H
-
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
-
G
-
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
DLL
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
P
I
F
S
I
R
V
I
I
-
T
-
W
L
R
D
-
L
G
A
S
L
A
P
Q
N
A
W
L
L
L
Q
G
L
E
T
L
A
V
R
I
E
K
H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
A
S
T
T
H
S
Q
L
S
E
E
E
L
Q
K
A
G
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
28
PsiBlast_CBE
92.38
46%
-97
- C1 -
4OC9
1
?
C:
[7-423]
-------
E
T
L
A
L
H
G
A
Y
N
F
D
T
Q
-
R
S
I
S
V
P
-
I
Y
Q
N
T
A
Y
N
F
E
N
L
D
Q
A
A
A
R
F
N
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
S
D
V
L
G
Q
R
L
A
N
V
E
G
G
A
F
G
I
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
S
H
T
L
K
N
F
G
I
E
A
R
E
F
D
-
I
D
-
D
-
L
D
S
L
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K
V
I
D
Q
N
T
K
A
I
F
F
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S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
-
H
-
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
-
G
-
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
DLL
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
P
I
F
S
I
R
V
I
I
-
T
-
W
L
R
D
-
L
G
A
S
L
A
P
Q
N
A
W
L
L
L
Q
G
L
E
T
L
A
V
R
I
E
K
H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
A
S
T
T
H
S
Q
L
S
E
E
E
L
Q
K
A
G
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
27
PsiBlast_CBE
92.17
46%
-98
- C1 -
4OC9
2
?
D:
[7-423]
-------
E
T
L
A
L
H
G
A
Y
N
F
D
T
Q
-
R
S
I
S
V
P
-
I
Y
Q
N
T
A
Y
N
F
E
N
L
D
Q
A
A
A
R
F
N
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
S
D
V
L
G
Q
R
L
A
N
V
E
G
G
A
F
G
I
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
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H
T
L
K
N
F
G
I
E
A
R
E
F
D
-
I
D
-
D
-
L
D
S
L
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K
V
I
D
Q
N
T
K
A
I
F
F
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S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
-
H
-
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
-
G
-
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
DLL
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
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I
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S
I
R
V
I
I
-
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-
W
L
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L
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A
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A
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Q
N
A
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L
L
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L
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L
A
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H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
A
S
T
T
H
S
Q
L
S
E
E
E
L
Q
K
A
G
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
2
PsiBlast_PDB
92.13
52%
-99
- C1 -
2CTZ
1
?
A:
[2-420]
-----
R
F
E
T
L
Q
L
H
A
G
Y
E
P
E
P
T
T
L
S
R
Q
V
P
-
I
Y
P
T
T
S
Y
V
F
K
S
P
E
H
A
A
N
L
F
A
L
K
E
F
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
G
I
E
V
R
F
T
S
-
R
E
-
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
-
K
-
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
-
G
-
H
G
A
V
I
A
G
A
I
V
D
G
G
N
F
P
---
W
E
G
G
R
Y
P
L
L
T
E
P
Q
P
G
Y
H
G
L
R
L
T
E
A
F
G
E
L
A
F
I
V
K
A
R
V
-
D
-
G
L
R
D
-
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
F
K
G
K
P
G
A
-
V
L
T
F
G
L
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
---
3
PsiBlast_PDB
91.86
46%
-98
- C1 -
4OC9
2
?
A:
[7-423]
-------
E
T
L
A
L
H
G
A
Y
N
F
D
T
Q
-
R
S
I
S
V
P
-
I
Y
Q
N
T
A
Y
N
F
E
N
L
D
Q
A
A
A
R
F
N
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
S
D
V
L
G
Q
R
L
A
N
V
E
G
G
A
F
G
I
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
S
H
T
L
K
N
F
G
I
E
A
R
E
F
D
-
I
D
-
D
-
L
D
S
L
E
K
V
I
D
Q
N
T
K
A
I
F
F
E
S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
-
H
-
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
-
G
-
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
D
L
L
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
P
I
F
S
I
R
V
I
I
-
T
-
W
L
R
D
-
L
G
A
S
L
A
P
Q
N
A
W
L
L
L
Q
G
L
E
T
L
A
V
R
I
E
K
H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
A
S
T
T
H
S
Q
L
S
E
E
E
L
Q
K
A
G
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
24
PsiBlast_CBE
90.95
52%
-96
- C1 -
2CTZ
1
?
B:
[2-420]
-----
R
F
E
T
L
Q
L
H
A
G
Y
E
P
E
P
T
T
L
S
R
Q
V
P
-
I
Y
P
T
T
S
Y
V
F
K
S
P
E
H
A
A
N
L
F
A
L
K
E
F
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
G
I
E
V
R
F
T
S
-
R
E
-
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
-
K
-
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
-
G
-
H
G
A
V
I
A
G
A
I
V
D
G
G
N
F
P
---
W
E
G
G
R
Y
P
L
L
T
E
P
Q
P
G
Y
H
G
L
R
L
T
E
A
F
G
E
L
A
F
I
V
K
A
R
V
-
D
-
G
L
R
D
-
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
F
K
G
K
P
G
A
-
V
L
T
F
G
L
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
---
25
PsiBlast_CBE
89.55
46%
-103
- C1 -
4OC9
1
?
O:
[7-423]
-------
E
T
L
A
L
H
G
A
Y
N
F
D
T
Q
-
R
S
I
S
V
P
-
I
Y
Q
N
T
A
Y
N
F
E
N
L
D
Q
A
A
A
R
F
N
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
S
D
V
L
G
Q
R
L
A
N
V
E
G
G
A
F
G
I
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
S
H
T
L
K
N
F
G
I
E
A
R
E
F
D
-
I
D
-
D
-
L
D
S
L
E
K
V
I
D
Q
N
T
K
A
I
F
F
E
S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
-
H
-
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
-
G
-
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
DLL
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
P
I
F
S
I
R
V
I
I
-
T
-
W
L
R
D
-
L
G
A
S
L
A
P
Q
N
A
W
L
L
L
Q
G
L
E
T
L
A
V
R
I
E
K
H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
-----------------
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
22
PsiBlast_CBE
88.58
55%
-106
- C1 -
4KAM
2
?
C:
[20-433]
----
W
S
F
E
T
K
Q
I
H
A
G
Q
Q
P
D
S
A
T
----
L
P
-
I
Y
Q
T
T
S
-----------------------
R
L
G
N
P
T
T
D
V
V
E
Q
R
I
A
A
L
E
G
G
V
A
A
L
F
L
S
S
G
Q
A
A
E
T
F
A
I
L
N
L
A
G
A
G
D
H
I
V
S
S
P
R
L
Y
G
G
T
Y
N
L
F
H
Y
S
L
A
K
L
G
I
E
V
S
F
V
D
D
P
D
-
N
-
L
D
S
W
Q
A
A
V
R
P
N
T
K
A
F
F
G
E
T
I
S
N
P
Q
I
D
L
L
D
T
P
G
V
A
E
V
A
H
R
-
N
-
G
-
I
P
L
I
V
D
N
T
I
A
T
P
-
Y
L
I
R
P
F
T
Q
G
A
D
I
V
V
H
S
A
T
K
Y
L
G
-
G
-
H
G
A
A
I
A
G
V
I
V
D
G
G
T
F
D
---
W
T
Q
G
R
F
P
E
F
T
T
P
D
P
S
Y
H
G
V
V
F
A
-
E
L
G
A
P
A
Y
A
L
K
A
R
V
-
Q
-
L
L
R
D
-
L
G
S
A
A
S
P
F
N
A
F
L
V
A
Q
G
L
E
T
L
S
L
R
I
E
R
H
V
S
N
A
Q
R
V
A
E
F
L
A
D
R
E
D
V
V
T
V
N
Y
A
G
L
P
G
S
P
W
H
E
R
A
K
K
L
S
P
K
G
T
G
A
-
V
L
S
F
E
L
A
G
G
V
E
A
G
K
A
F
V
N
A
L
K
L
H
S
H
V
A
N
I
G
D
V
R
S
L
V
I
H
-------------------
S
P
G
L
V
R
L
A
V
G
I
E
G
I
E
D
I
L
A
D
L
-------
107
HHSearch
88.52
46%
-101
- C1 -
2RFV
1
?
A:
[5-396]
--
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
-
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
-----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
R
F
V
D
-
A
A
-
K
-
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
-
H
G
D
V
I
G
G
I
I
V
G
K
Q
E
----------------------------------
F
I
D
Q
A
R
F
V
G
-
L
K
D
I
-
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
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M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
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G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
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T
L
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Q
H
P
A
S
M
T
H
S
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V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
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L
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V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
6
PsiBlast_PDB
87.67
43%
-102
- C1 -
3JW9
2
?
A:
[4-395]
-
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
-
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
-
A
A
-
K
-
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
-
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
-
V
-
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
-
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
10
PsiBlast_PDB
87.65
43%
-104
- C1 -
3JWB
4
?
A:
[7-395]
----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
-
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
-
A
A
-
K
-
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
-
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
-
V
-
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
-
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
4
PsiBlast_PDB
87.33
43%
-103
- C1 -
4OMA
6
?
A:
[4-395]
-
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
-
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
-
A
A
-
K
-
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
-
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
-
V
-
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
-
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
11
PsiBlast_PDB
87.19
43%
-105
- C1 -
2RFV
1
?
A:
[7-395]
----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
-
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
-----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
R
F
V
D
-
A
A
-
K
-
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
-
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
-
V
-
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
-
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
1
PsiBlast_PDB
86.91
55%
-106
- C1 -
4KAM
2
?
A:
[20-433]
----
W
S
F
E
T
K
Q
I
H
A
G
Q
Q
P
D
S
-----
A
L
P
-
I
Y
Q
T
T
S
--------------------------
N
P
T
T
D
V
V
E
Q
R
I
A
A
L
E
G
G
V
A
A
L
F
L
S
S
G
Q
A
A
E
T
F
A
I
L
N
L
A
G
A
G
D
H
I
V
S
S
P
R
L
Y
G
G
T
Y
N
L
F
H
Y
S
L
A
K
L
G
I
E
V
S
F
V
D
D
P
D
-
N
-
L
D
S
W
Q
A
A
V
R
P
N
T
K
A
F
F
G
E
T
I
S
N
P
Q
I
D
L
L
D
T
P
G
V
A
E
V
A
H
R
-
N
-
G
-
I
P
L
I
V
D
N
T
I
A
T
P
-
Y
L
I
R
P
F
T
Q
G
A
D
I
V
V
H
S
A
T
K
Y
L
G
-
G
-
H
G
A
A
I
A
G
V
I
V
D
G
G
T
F
D
---
W
T
Q
G
R
F
P
E
F
T
T
P
D
P
S
Y
H
G
V
V
F
A
-
E
L
G
A
P
A
Y
A
L
K
A
R
V
-
Q
-
L
L
R
D
-
L
G
S
A
A
S
P
F
N
A
F
L
V
A
Q
G
L
E
T
L
S
L
R
I
E
R
H
V
S
N
A
Q
R
V
A
E
F
L
A
D
R
E
D
V
V
T
V
N
Y
A
G
L
P
G
S
P
W
H
E
R
A
K
K
L
S
P
K
G
T
G
A
-
V
L
S
F
E
L
A
G
G
V
E
A
G
K
A
F
V
N
A
L
K
L
H
S
H
V
A
N
I
G
D
V
R
S
L
V
I
H
---------------------
G
L
V
R
L
A
V
G
I
E
G
I
E
D
I
L
A
D
L
-------
5
PsiBlast_PDB
86.76
43%
-104
- C1 -
4HF8
5
?
A:
[7-395]
----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
-
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
R
F
V
D
-
A
A
-
K
-
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
-
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
-
V
-
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
-
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
9
PsiBlast_PDB
86.56
43%
-102
- C1 -
3JWA
6
?
A:
[7-395]
----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
-
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
A
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
-
A
A
-
K
-
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
-
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
-
V
-
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
-
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
21
PsiBlast_CBE
86.26
55%
-106
- C1 -
4KAM
2
?
D:
[20-433]
----
W
S
F
E
T
K
Q
I
H
A
G
Q
------
N
A
R
A
L
P
-
I
Y
Q
T
T
S
Y
----------------------
R
L
G
N
P
T
T
D
V
V
E
Q
R
I
A
A
L
E
G
G
V
A
A
L
F
L
S
S
G
Q
A
A
E
T
F
A
I
L
N
L
A
G
A
G
D
H
I
V
S
S
P
R
L
Y
G
G
T
Y
N
L
F
H
Y
S
L
A
K
L
G
I
E
V
S
F
V
D
D
P
D
-
N
-
L
D
S
W
Q
A
A
V
R
P
N
T
K
A
F
F
G
E
T
I
S
N
P
Q
I
D
L
L
D
T
P
G
V
A
E
V
A
H
R
-
N
-
G
-
I
P
L
I
V
D
N
T
I
A
T
P
-
Y
L
I
R
P
F
T
Q
G
A
D
I
V
V
H
S
A
T
K
Y
L
G
-
G
-
H
G
A
A
I
A
G
V
I
V
D
G
G
T
F
D
---
W
T
Q
G
R
F
P
E
F
T
T
P
D
P
S
Y
H
G
V
V
F
A
-
E
L
G
A
P
A
Y
A
L
K
A
R
V
-
Q
-
L
L
R
D
-
L
G
S
A
A
S
P
F
N
A
F
L
V
A
Q
G
L
E
T
L
S
L
R
I
E
R
H
V
S
N
A
Q
R
V
A
E
F
L
A
D
R
E
D
V
V
T
V
N
Y
A
G
L
P
G
S
P
W
H
E
R
A
K
K
L
S
P
K
G
T
G
A
-
V
L
S
F
E
L
A
------
K
A
F
V
N
A
L
K
L
H
S
H
V
A
N
I
G
D
V
R
S
L
V
I
H
P
------------------
S
P
G
L
V
R
L
A
V
G
I
E
G
I
E
D
I
L
A
D
L
-------
23
PsiBlast_CBE
85.93
55%
-101
- C1 -
4KAM
2
?
B:
[20-433]
----
W
S
F
E
T
K
Q
I
H
A
G
Q
------
N
A
R
A
L
P
-
I
Y
Q
T
T
S
----------------------
T
R
L
G
N
P
T
T
D
V
V
E
Q
R
I
A
A
L
E
G
G
V
A
A
L
F
L
S
S
G
Q
A
A
E
T
F
A
I
L
N
L
A
G
A
G
D
H
I
V
S
S
P
R
L
Y
G
G
T
Y
N
L
F
H
Y
S
L
A
K
L
G
I
E
V
S
F
V
D
D
P
D
-
N
-
L
D
S
W
Q
A
A
V
R
P
N
T
K
A
F
F
G
E
T
I
S
N
P
Q
I
D
L
L
D
T
P
G
V
A
E
V
A
H
R
-
N
-
G
-
I
P
L
I
V
D
N
T
I
A
T
P
-
Y
L
I
R
P
F
T
Q
G
A
D
I
V
V
H
S
A
T
K
Y
L
G
-
G
-
H
G
A
A
I
A
G
V
I
V
D
G
G
T
F
D
---
W
T
Q
G
R
F
P
E
F
T
T
P
D
P
S
Y
H
G
V
V
F
A
-
E
L
G
A
P
A
Y
A
L
K
A
R
V
-
Q
-
L
L
R
D
-
L
G
S
A
A
S
P
F
N
A
F
L
V
A
Q
G
L
E
T
L
S
L
R
I
E
R
H
V
S
N
A
Q
R
V
A
E
F
L
A
D
R
E
D
V
V
T
V
N
Y
A
G
L
P
G
S
P
W
H
E
R
A
K
K
L
S
P
K
G
T
G
A
-
V
L
S
F
E
L
A
G
G
V
E
A
G
K
A
F
V
N
A
L
K
L
H
S
H
V
A
N
I
G
D
V
R
S
L
V
I
H
-------------------
S
P
G
L
V
R
L
A
V
G
I
E
G
I
E
D
I
L
A
D
L
-------
7
PsiBlast_PDB
84.39
43%
-106
- C1 -
3MKJ
1
?
A:
[7-395]
----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
-
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
-----------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
-
A
A
-
K
-
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
-
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
-
V
-
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
-
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
30
PsiBlast_CBE
81.15
37%
-100
- C1 -
1E5F
5
?
B:
[17-395]
-----------------
P
Q
K
D
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
-
T
A
-
I
-
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
-
H
T
D
V
V
A
G
L
I
----------------------------------
C
G
K
A
D
L
L
Q
Q
I
R
M
-
V
-
G
I
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
-
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
31
PsiBlast_CBE
80.87
37%
-102
- C1 -
1E5E
6
?
B:
[17-395]
-----------------
P
Q
K
D
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
-
T
A
-
I
-
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
-
H
T
D
V
V
A
G
L
I
----------------------------------
C
G
K
A
D
L
L
Q
Q
I
R
M
-
V
-
G
I
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
-
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
106
HHSearch
80.03
39%
-95
- C1 -
1E5E
5
?
A:
[4-395]
--
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
-
Q
F
G
A
A
I
P
P
-
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
-
T
A
-
I
-
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
E
-
G
-
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
T
D
V
V
A
G
L
I
-
C
G
K
A
D
----------------------------------
L
L
Q
Q
I
R
M
-
V
G
I
K
D
I
-
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
-
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
14
PsiBlast_PDB
80.01
37%
-101
- C1 -
1E5F
6
?
A:
[17-395]
-----------------
P
Q
K
D
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
-
T
A
-
I
-
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
-
H
T
D
V
V
A
G
L
I
----------------------------------
C
G
K
A
D
L
L
Q
Q
I
R
M
-
V
-
G
I
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
-
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
13
PsiBlast_PDB
79.60
37%
-99
- C1 -
1E5E
5
?
A:
[17-395]
-----------------
P
Q
K
D
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
-
T
A
-
I
-
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
-
H
T
D
V
V
A
G
L
I
----------------------------------
C
G
K
A
D
L
L
Q
Q
I
R
M
-
V
-
G
I
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
-
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
115
HHSearch
77.85
43%
-108
- C1 -
1PFF
18
?
A:
[2-330]
------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
G
V
E
V
D
F
I
D
-
M
A
-
V
-
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
K
-
D
-
I
L
V
I
V
D
N
T
F
A
S
P
-
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
-
T
D
V
V
A
G
L
V
C
S
R
A
-
D
----------------------------------
I
I
A
K
V
K
S
-
Q
G
I
K
D
I
-
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
-
K
M
F
G
S
-
M
I
A
F
D
V
D
G
L
-
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
85
PsiBlast_CBE
77.14
39%
-110
- C1 -
1PFF
18
?
A:
[1-330]
-----------------------------------------------------------------
S
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
G
V
E
V
D
F
I
D
-
M
A
-
V
-
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
-
Q
K
D
-
I
L
V
I
V
D
N
T
F
A
S
P
-
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
-
G
-
H
T
D
V
V
A
G
L
V
----------------------------------
C
S
R
A
D
I
I
A
K
V
K
S
-
Q
-
G
I
K
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
-
K
M
F
G
S
-
M
I
A
F
D
V
D
-
G
L
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V