@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0605: (2016-03-17 )
VSSVHKVASISLFTLAWPIFLEQFLRLMISYIDVFMLGHYSDDAVAATGVANQILVISIIIYGFISVGVQIIVAQMIGAKKHKEIENVITNGLVVAFLIGIVMSIIFIFMSKNFLTWMGIDPHLVQVGAPFLEIIGGSSVVIAIHASILPILRAHGYVRQSILVPVTISIINVVGNYLFLYGPLAYLDYGVAGVGISTAVANFVGMGLAIWMLRKYIGYTFHFKKLEQVSKKLLYSILRLGLPSAGENLSYAGSQLVVTAIIAILGTEALTTKVYASTVSQFVALFAIALGQASQIIIGRAVGAKEIDKAYKQGLRSWKIGLVVAIVVSVSIYLFAEPIMRLFTTNTEIIAMTKELFLLSIFLELGRATNIIIISSLNSTGDVRFPFICGLIVMWIVSLPFSYVLGISAGLGLVGVWLAYIIDEGVRAVLMYRRWRSKVWSLKSVI
Atome Classification :
(20 SA)
---.....--....10--........20........30........-40.-.......50........60........70........80........90........100.......110.......120.......130.......140.......-150----------------...----....160.......170.......180.......190.......200..-.....210..--.--.....220...-....230-----........240.......250.......260.-.....---.-270....--...280.......290.......300.......310........320.......330.......340.....-------..350-.........360.......370.......380.......390.......400......-----.-----410.......420.......430..--...--..440....------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---VSS
V
H
--
K
V
A
S
I
S
--
L
F
T
L
A
W
P
I
F
L
E
Q
F
L
R
L
M
I
S
Y
I
D
V
F
M
LGH-YSD-D
A
V
A
ATGVANQ
I
L
V
I
S
I
I
I
Y
G
F
I
S
V
G
V
Q
I
I
V
A
Q
M
IG
A
K
K
H
K
E
I
E
N
V
I
TN
G
L
V
V
A
F
L
I
G
I
V
M
S
I
I
F
I
F
MSKN
F
L
T
WMGID
P
H
L
V
Q
VG
A
P
F
L
E
IIGG
S
S
V
V
I
A
I
H
A
S
I
L
-
P
I
L
----------------
R
AH----
G
Y
V
R
Q
S
I
L
V
P
V
T
I
S
I
I
N
V
VG
N
Y
L
F
L
YG
P
L
A
Y
L
D
YGVAGV
G
I
S
T
A
V
A
N
F
V
-
G
M
G
L
A
I
-
W
M
L
--
R
--
K
YIGY
T
F
H
F
K
K
-
L
E
Q
V
S
K
------
K
L
L
Y
S
I
L
R
LGLPSAGENLSYAG
S
Q
L
V
V
T
A
I
I
A
-
I
LGT
E
---
A
-
L
T
T
K
V
Y
A
--
S
T
V
S
Q
F
V
A
L
F
A
I
A
LGQA
S
Q
I
I
I
GRAV
G
A
K
E
I
D
K
A
-
Y
K
Q
G
L
R
SWK
I
G
L
V
V
A
I
V
V
S
V
S
I
Y
L
F
A
E
P
I
M
R
L
FTTNT-------
E
I
I
---
A
M
T
K
E
L
F
L
L
S
I
F
L
E
LGRAT
N
I
I
I
I
SSLNSTGDV
R
F
P
F
I
C
G
L
I
V
M
W
I
V
S
L
P
F
S
Y
V
L
GIS-----A-----
G
L
G
L
V
G
V
W
L
A
Y
I
I
D
E
G
V
R
A
V
L
M
Y
R
R
--
W
R
S
--
K
V
W
S
L
K
SVI------
1
PsiBlast_PDB
93.09
23%
-115
- C2 -
3MKT
-
?
A:
[3-449]
----
N
S
V
H
R
Y
K
K
E
A
S
N
--
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
-
V
S
A
-
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
-
I
A
V
L
F
Q
T
Q
F
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
-----
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
----------------
R
S
F
TDGM
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
-
M
L
L
L
L
L
-
F
Y
I
VT
S
--
K
R
L
A
H
V
K
V
F
E
T
-
F
H
K
P
Q
P
------
K
E
L
I
R
L
F
R
L
G
F
P
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
-
P
L
G
S
T
---
V
-
V
A
A
H
Q
V
A
--
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
-
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
-------
V
V
V
---
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
W
V
L
G
L
P
T
G
Y
I
L
G
M
T
NWLTE
Q
-----
P
L
G
A
K
G
F
W
L
G
F
I
I
G
L
S
A
A
A
L
M
L
G
Q
R
LY
W
L
Q
--
K
--------------
2
PsiBlast_PDB
92.87
23%
-115
- C2 -
3MKU
1
?
A:
[2-448]
----
N
S
V
H
R
Y
K
K
E
A
S
N
--
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
-
V
S
A
-
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
-
I
A
V
L
F
Q
T
Q
F
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
-----
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
----------------
R
S
F
TDGM
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
-
M
L
L
L
L
L
-
F
Y
I
VT
S
--
K
R
L
A
H
V
K
V
F
E
T
-
F
H
K
P
Q
P
------
K
E
L
I
R
L
F
R
L
G
F
P
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
-
P
L
G
S
T
---
V
-
V
A
A
H
Q
V
A
--
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
-
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
-------
V
V
V
---
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
W
V
L
G
L
P
T
G
Y
I
L
G
M
T
NWLTE
Q
-----
P
L
G
A
K
G
F
W
L
G
F
I
I
G
L
S
A
A
A
L
M
L
G
Q
R
L
Y
W
L
Q
--
K
--------------
12
PsiBlast_PDB
92.79
21%
-130
- C2 -
3WBN
6
?
A:
[23-453]
---------------------
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
-
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
-
W
L
F
--
V
--
K
R
D
T
Y
V
D
I
T
L
R
-
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
-
T
A
G
G
E
N
G
V
A
-
V
F
T
S
A
W
R
--
I
T
M
L
G
I
V
P
I
L
G
M
A
--
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
S
E
SAQVI
K
G
D
L
I
---
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
----
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
--
R
I
S
A
L
K
K
--------
11
PsiBlast_PDB
91.90
21%
-128
- C2 -
3VVS
13
?
A:
[23-453]
---------------------
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
-
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
-
W
L
F
--
V
--
K
R
D
T
Y
V
D
I
T
L
R
-
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
-
T
A
G
G
E
N
G
V
A
-
V
F
T
S
A
W
R
--
I
T
M
L
G
I
V
P
I
L
G
M
A
--
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
---I
K
G
----
D
L
I
---
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
----
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
--
R
I
S
A
L
K
K
--------
10
PsiBlast_PDB
91.65
21%
-128
- C2 -
3VVR
4
?
A:
[23-453]
---------------------
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
-
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
-
W
L
F
--
V
--
K
R
D
T
Y
V
D
I
T
L
R
-
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
-
T
A
G
-
E
N
G
V
A
-
V
F
T
S
A
W
R
--
I
T
M
L
G
I
V
P
I
L
G
M
A
--
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
--I
K
G
----
D
L
I
---
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
----
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
--------------
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
--
R
I
S
A
L
K
K
--------
13
PsiBlast_PDB
91.54
21%
-128
- C2 -
4MLB
22
?
A:
[30-460]
---------------------
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
-
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
-
W
L
F
--
V
--
K
R
D
T
Y
V
D
I
T
L
R
-
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
-
T
A
G
G
E
N
G
V
A
-
V
F
T
S
A
W
R
--
I
T
M
L
G
I
V
P
I
L
G
M
A
--
T
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
S
E
SAQVI
K
G
D
L
I
---
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
----
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
--
R
I
S
A
L
K
K
--------
24
Fugue
91.53
21%
-115
- C2 -
3MKT
-
?
A:
[2-461]
-EN
S
V
H
R
Y
--
K
K
E
A
S
N
--
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
-
V
S
A
-
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
V
L
F
Q
T
Q
F
-
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
R
-
S
F
T
----------------
D
G
M
----
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
-
M
L
L
L
L
L
-
F
Y
I
--
V
TS
K
R
L
A
H
V
K
V
F
E
T
-
F
H
K
P
Q
P
------
K
E
L
I
R
L
F
R
L
G
F
P
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
-
P
L
G
S
T
---
V
-
V
A
A
H
Q
V
A
--
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
-
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
-------
V
V
V
---
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
W
V
L
G
L
P
T
G
Y
I
L
G
M
T
-----
N
WLTEQ
P
L
G
A
K
G
F
W
L
G
F
I
I
G
L
S
A
A
A
L
M
L
G
Q
R
--
L
Y
W
--
L
Q
K
Q
S
D
D
V
Q
L
H
L
A
A
K
8
PsiBlast_PDB
91.19
21%
-127
- C2 -
3VVO
10
?
A:
[23-453]
---------------------
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
-
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
-
W
L
F
--
V
--
K
R
D
T
Y
V
D
I
T
L
R
-
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
-
T
A
G
G
E
N
G
V
A
-
V
F
T
S
A
W
R
--
I
T
M
L
G
I
V
P
I
L
G
M
A
--
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
--IK
G
----
D
L
I
---
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
----
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
--
R
I
S
A
L
K
K
--------
7
PsiBlast_PDB
91.15
21%
-132
- C2 -
3VVN
12
?
A:
[23-453]
---------------------
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
-
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
--
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
-
W
L
F
--
V
--
K
R
D
T
Y
V
D
I
T
L
R
-
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
-
T
A
G
G
E
N
G
V
A
-
V
F
T
S
A
W
R
--
I
T
M
L
G
I
V
P
I
L
G
M
A
--
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
---AQVI
K
G
-
D
L
I
---
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
----
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
--
R
I
S
A
L
K
K
--------
9
PsiBlast_PDB
91.00
21%
-131
- C2 -
3VVP
1
?
A:
[23-453]
---------------------
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
-
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
-------
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
-
W
L
F
--
V
--
K
R
D
T
Y
V
D
I
----
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
-
T
A
G
G
E
NG
V
A
-
V
F
T
S
A
W
R
--
I
T
M
L
G
I
V
P
I
L
G
M
A
--
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
--------------------
D
L
I
---
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
----
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
--
R
I
S
A
L
K
K
--------
5
PsiBlast_PDB
89.08
21%
-106
- C2 -
4HUM
1
?
A:
[16-442]
------------------
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
-
A
G
K
-
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
M
V
H
R
A
L
H
-
A
Y
A
----------------
S
S
L
----
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
-
M
A
V
F
W
-
F
S
A
L
A
L
-
W
I
-------
Y
I
A
K
E
K
F
F
R
P
-
F
G
L
T
A
K
F
G
K
PDW
A
V
F
K
Q
I
W
K
I
G
A
P
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
-
P
F
G
E
D
---
Y
-
V
A
A
Q
Q
V
G
--
I
S
L
S
G
I
L
Y
M
I
P
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
-
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
-------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
W
G
C
G
L
L
P
G
Y
L
L
A
Y
R
-----
F
-----
D
M
G
I
Y
G
F
W
T
A
L
I
A
S
L
T
I
A
A
V
A
L
-----------
V
W
C
L
E
---------
20
HHSearch
88.35
19%
-134
- C2 -
3W4T
9
?
A:
[14-446]
----------
G
D
P
K
K
A
--
I
V
R
L
S
I
A
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
-
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
T
----
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
-
T
S
L
F
I
A
-
Y
W
L
--
F
--
V
K
R
D
T
Y
V
D
I
T
L
R
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
G
E
N
---
G
-
V
A
V
F
T
S
A
--
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
------------VI
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
-----------------
3
PsiBlast_PDB
88.16
21%
-108
- C2 -
4HUK
1
?
A:
[16-442]
------------------
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
-
A
G
K
-
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
M
V
H
R
A
L
H
-
A
Y
A
----------------
S
S
L
----
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
-
M
A
V
F
W
-
F
S
A
L
A
L
-
W
I
-------
Y
I
A
K
E
K
F
F
R
P
-
F
G
L
T
A
K
F
G
K
PDW
A
V
F
K
Q
I
W
K
I
G
A
P
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
-
P
F
G
E
D
---
Y
-
V
A
A
Q
Q
V
G
--
I
S
L
S
G
I
L
Y
M
I
P
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
-
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
-------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
W
G
C
G
L
L
P
G
Y
L
L
A
Y
R
-----
F
-----
D
M
G
I
Y
G
F
W
T
A
L
I
A
S
L
T
I
A
A
V
A
L
-----------
V
W
C
L
E
---------
6
PsiBlast_PDB
87.96
21%
-108
- C2 -
4HUN
1
?
A:
[16-442]
------------------
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
-
A
G
K
-
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
M
V
H
R
A
L
H
-
A
Y
A
----------------
S
S
L
----
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
-
M
A
V
F
W
-
F
S
A
L
A
L
-
W
I
-------
Y
I
A
K
E
K
F
F
R
P
-
F
G
L
T
A
K
F
G
K
PDW
A
V
F
K
Q
I
W
K
I
G
A
P
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
-
P
F
G
E
D
---
Y
-
V
A
A
Q
Q
V
G
--
I
S
L
S
G
I
L
Y
M
I
P
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
-
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
-------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
W
G
C
G
L
L
P
G
Y
L
L
A
Y
R
-----
F
-----
D
M
G
I
Y
G
F
W
T
A
L
I
A
S
L
T
I
A
A
V
A
L
-----------
V
W
C
L
E
---------
25
Fugue
87.68
20%
-121
- C2 -
4LZ6
-
?
A:
[1-446]
QKQ
Q
S
E
R
L
--
G
T
E
A
I
P
KL
L
R
S
L
S
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
I
F
I
S
Y
A
V
G
I
-
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
L
V
L
S
V
I
G
F
I
S
A
F
T
L
L
G
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
L
L
G
S
I
F
F
F
F
A
F
A
A
N
-
N
I
I
----------------
R
S
E
----
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
----
L
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
S
-
V
T
G
L
V
L
R
Y
F
L
--
T
--
G
K
S
T
L
S
L
H
W
S
D
-
L
R
M
-
K
G
------
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
M
L
L
-
R
F
G
S
D
---
F
Y
V
G
V
F
G
L
V
--
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
-
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
A
D
R
-------
E
V
I
---
Q
A
G
V
S
A
M
H
I
L
F
C
V
T
F
L
I
G
A
Q
I
V
A
G
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
S
L
S
R
Q
I
I
F
L
I
P
L
V
L
I
L
--
P
-----
H
-----
I
F
G
L
S
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
T
V
V
L
--
L
Y
R
D
R
N
V
F
F
L
K
---------
4
PsiBlast_PDB
87.47
21%
-103
- C2 -
4HUL
1
?
A:
[16-442]
------------------
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
-
A
G
K
-
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
M
V
H
R
A
L
H
-
A
Y
A
----------------
S
S
L
----
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
-
M
A
V
F
W
-
F
S
A
L
A
L
-
W
I
-------
Y
I
A
K
E
K
F
F
R
P
-
F
G
L
T
A
K
F
G
K
PDW
A
V
F
K
Q
I
W
K
I
G
A
P
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
-
P
F
G
E
D
---
Y
-
V
A
A
Q
Q
V
G
--
I
S
L
S
G
I
L
Y
M
I
P
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
-
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
-------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
W
G
C
G
L
L
P
G
Y
L
L
A
Y
R
-----
F
-----
D
M
G
I
Y
G
F
W
T
A
L
I
A
S
L
T
I
A
A
V
A
L
-----------
V
W
C
L
E
---------
14
PsiBlast_PDB
86.07
22%
-124
- C2 -
3W4T
9
?
A:
[51-453]
---------------------------------------------------
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
-
G
I
L
----------------
R
G
E
----
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
-
W
L
F
--
V
--
K
R
D
T
Y
V
D
I
T
L
R
-
D
F
S
P
S
R
------
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
-
T
A
G
G
E
N
G
V
A
-
V
F
T
S
A
W
R
--
I
T
M
L
G
I
V
P
I
L
G
M
A
--
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
-
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
--VI
K
G
---
D
L
I
---
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
----
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
--
G
R
M
--
R
I
S
A
L
K
K
--------
15
PsiBlast_PDB
71.06
21%
-127
- C2 -
4LZ6
-
?
A:
[17-353]
------------------
L
R
S
L
S
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
I
F
I
S
Y
-
A
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
----
L
V
L
S
V
I
G
-
F
I
S
A
--
F
T
L
L
G
----------
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
L
L
GSIFF
F
F
A
F
A
A
N
N
I
I
R
S
E
----
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
----
L
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
S
-
V
T
G
L
V
L
R
Y
F
L
--
T
--
G
K
S
T
L
S
L
H
W
S
D
-
L
-
R
M
K
G
------
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
M
L
L
-
R
F
G
S
D
-----
F
Y
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
-
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
A
D
R
-------
E
V
I
-----------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.71
21%
-138
- C- -
4LZ9
1
?
A:
[17-353]
------------------
L
R
S
L
S
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
I
F
I
S
Y
-
A
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
----
L
V
L
S
V
I
G
-
F
I
S
A
--
F
T
L
L
G
----------
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
L
LG
S
I
F
F
F
F
A
F
A
A
N
N
I
I
R
S
E
----
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
----
L
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
S
-
V
T
G
L
V
L
R
Y
F
L
--
T
--
G
K
S
T
L
S
L
H
W
S
D
-
L
-
R
M
K
G
------
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
M
L
L
-
R
F
G
S
D
-----
F
Y
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
-
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
A
D
R
-------
E
V
I
-----------------------------------------------------------------------------------------------------------------------
21
HHSearch
61.93
16%
-97
- C2 -
3W4T
8
?
A:
[13-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
------
D
P
K
K
A
I
V
R
L
S
I
A
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
-
G
L
G
P
E
---
S
-
L
A
A
V
G
L
F
--
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
-
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
K
G
-------
E
A
V
---
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
-
L
N
I
V
L
D
P
I
F
I
Y
T
-----
L
-----
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
-------------------------