@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0607: (2016-03-17 )
MKRLKPYWLSITAVLVLTFGQVIGQLYLPTLMSNIIDKGVVTGDTDYIWSTGMKMLLISFASVILSVIVVYLASRISMGFGKELRDKIFTKVEDFSLQEFDKVGTSSLITRTTNDVVQIQNVLYMMMRLMVMAPIMLLGGIIMAVGRDAKLSLIFVVVLPLLLLLVVILGGKAMPMFKSLQKKMDKLNRVIREGLTGIRVVRSFNRNEDELEKFEEANADYATTAIKVNRLLSLMSPLMMLLMNLTSIAIVWIGSIFIGNGDMQVGDLMAFIQYAMQIMMSFMMLSAVFIMIPRAGASAERINEVLDMNAEILNPENPKTSTPPAKLSFEHVTFRYEGAEKPVIEDITFEANAGETIAIIGSTGAGKSTLINMIPRFYDVESGVVKINGIDVREMDQSSLRQKIGLVPQKAVLFTGTIASNMRYGKEDATDEEIWEALRTAQAENFVSKLANGLGSRVEQGGNNFSGGQKQRLSIARSLIRKPEIYIFDDSFSALDFKTDAKLREALKAETTEAVTLIVAQRITSVVNSDQIIVMNEGKIAGMGTHEELKESNQIYQEIMRSQLSEEEIA
Atome Classification :
(39 SA)
--------------------------------------------------------------------------------.........10......-..20........30........40...---.---.-----.---..50........60.....-----...70....-....80.---.----......90.-----.......100.--------------......110.......120.......130.......140.......150.......160.......170.......180-.......190.......200.......210.......220.......230.......240--------.........250........260.......270.......280.......290.......300---.........310-.....----.-----.--.320.....--...330....-..-.-340..--.....350.......360.......370.......380--........390--.--......400.......--410.......420....-..---.---430...-....440....-...450-.......460.......470.......480.......490.......500......--.510-...--.....520......-.--530.......540....-..-.550--.......560.......570------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------MKRLKP
Y
W
L
S
I
T
A
V
L
V
L
-
T
F
G
Q
V
I
G
Q
L
Y
L
P
T
L
M
S
N
I
I
DKGVVTGD---T---
D
-----
Y
---
I
W
S
T
G
M
K
M
L
L
I
S
F
A
S
V
I
L
S
-----
V
I
V
V
Y
L
A
S
R
-
I
SMGF
G
K
---
E
----
L
R
D
K
I
F
T
K
V
-----
E
DF
S
L
Q
E
F
D
KV--------------GT
S
S
L
I
TRTTN
D
V
V
Q
I
Q
N
V
L
Y
M
M
M
R
L
M
V
M
A
P
I
M
L
L
G
G
I
I
M
AVGRDA
K
L
S
L
I
F
V
V
V
L
P
L
L
L
L
L
V
V
I
LGGKA
M
P
M
F
K
S
L
Q
K
-
K
M
D
K
L
N
R
V
I
R
EGL
T
G
I
R
V
V
R
SFNR
N
E
D
E
L
E
K
F
E
EANADYA
T
T
A
I
K
V
N
R
L
L
S
L
M
S
P
L
M
M
----------
L
L
M
N
L
T
S
I
A
I
V
-
W
I
G
S
I
F
IGNGDM
Q
V
G
D
L
M
A
F
I
Q
Y
A
M
Q
I
M
M
S
F
M
M
L
S
A
V
F
I
MIPRAGA
S
A
E
-----
R
I
N
E
V
L
DMN
A
E
--ILNPE----N-----P--KT-STPPA
K
--
L
S
F
E
H
V
T
F
R
Y-EG-A-EKP
V
I
--
E
D
I
T
F
EANAG
E
T
I
A
I
I
GSTGA
G
K
S
T
L
I
N
M
I
P
R
F
YDVE---S
G
V
V
K
I
NGI
D
V
--
R
--EM
D
Q
S
S
L
R
Q
K
IGLVPQ--
K
A
V
L
F
T
G
TIASNMRYGK-ED---A---
T
D
E
E
I
W
-
E
A
L
R
T
A
Q
A
E
N
F
-
V
S
K
L
A
N
-
G
L
G
S
R
V
E
QGGNNFSG
G
Q
K
Q
R
L
S
I
A
R
S
L
IRKP
E
I
Y
I
FDDSFSALDFKT
D
A
K
L
R
E
A
L
K--AET--
T
E
A
--
V
T
L
I
V
A
Q
R
I
T
S
V
VN-S--
D
Q
I
I
V
MNEG
K
I
AGMG
T
H
-
E
E
-
L
K
E
S
--
N
Q
I
Y
Q
E
I
M
R
S
Q
L
S
EEEIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.59
42%
-117
- C2 -
4Q4H
-
?
A:
[16-579]
---------------------------------------------------------------------------------
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
-
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
---
F
---
S
-----
L
---
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
-----
I
G
C
T
V
F
A
S
Y
-
A
S
Q
N
F
G
A
---
D
----
L
R
R
D
L
F
R
K
V
-----
L
S
F
S
I
S
N
V
N
R
F
--------------
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
-
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
----------
F
I
V
N
M
G
M
I
A
V
L
-
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
-----
R
V
L
E
V
L
N
E
K
P
A
--
I
E
E
A
D
----
N
-----
A
L
-
A
L
-
P
N
V
E
G
S
--
V
S
F
E
N
V
E
F
R
Y
-
F
E
-
N
-
T
D
P
V
L
--
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
--
R
--
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
--
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
-
E
D
---
A
---
T
D
D
E
I
V
-
E
A
A
K
I
A
Q
I
H
D
F
-
I
I
S
L
P
E
-
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
T
--
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
--
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
-
K
E
-
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.94
42%
-116
- C2 -
4Q4J
-
?
A:
[16-579]
---------------------------------------------------------------------------------
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
-
M
V
V
E
V
I
S
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
---
F
---
S
-----
L
---
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
-----
I
G
S
T
V
F
A
S
Y
-
A
S
Q
N
F
G
A
---
D
----
L
R
R
D
L
F
R
K
V
-----
L
S
F
S
I
S
N
V
N
R
F
--------------
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
-
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
----------
F
I
V
N
M
G
M
I
A
V
L
-
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
-----
R
V
L
E
V
L
N
E
K
P
A
--
I
E
E
A
D
----
N
-----
A
L
-
A
L
-
P
N
V
E
G
S
--
V
S
F
E
N
V
E
F
R
Y
-
F
E
-
N
-
T
D
P
V
L
--
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
--
R
--
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
--
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
-
E
D
---
A
---
T
D
D
E
I
V
-
E
A
A
K
I
A
Q
I
H
D
F
-
I
I
S
L
P
E
-
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
S
T
C
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
T
--
K
G
S
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
--
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
-
K
E
-
L
L
E
H
--
S
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.54
42%
-121
- C2 -
3QF4
2
?
A:
[16-579]
---------------------------------------------------------------------------------
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
-
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
---
F
---
S
-----
L
---
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
-----
I
G
C
T
V
F
A
S
Y
-
A
S
Q
N
F
G
A
---
D
----
L
R
R
D
L
F
R
K
V
-----
L
S
F
S
I
S
N
V
N
R
F
--------------
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
-
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
----------
F
I
V
N
M
G
M
I
A
V
L
-
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
-----
R
V
L
E
V
L
N
E
K
P
A
--
I
E
E
A
D
----
N
-----
A
L
-
A
L
-
P
N
V
E
G
S
--
V
S
F
E
N
V
E
F
R
Y
-
F
E
-
N
-
T
D
P
V
L
--
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
--
R
--
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
--
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
-
E
D
---
A
---
T
D
D
E
I
V
-
E
A
A
K
I
A
Q
I
H
D
F
-
I
I
S
L
P
E
-
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
T
--
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
--
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
-
K
E
-
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.67
42%
-121
- C2 -
4Q4A
2
?
A:
[16-579]
---------------------------------------------------------------------------------
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
-
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
---
F
---
S
-----
L
---
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
-----
I
G
C
T
V
F
A
S
Y
-
A
S
Q
N
F
G
A
---
D
----
L
R
R
D
L
F
R
K
V
-----
L
S
F
S
I
S
N
V
N
R
F
--------------
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
-
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
----------
F
I
V
N
M
G
M
I
A
V
L
-
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
-----
R
V
L
E
V
L
N
E
K
P
A
--
I
E
E
A
D
----
N
-----
A
L
-
A
L
-
P
N
V
E
G
S
--
V
S
F
E
N
V
E
F
R
Y
-
F
E
-
N
-
T
D
P
V
L
--
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
--
R
--
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
--
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
-
E
D
---
A
---
T
D
D
E
I
V
-
E
A
A
K
I
A
Q
I
H
D
F
-
I
I
S
L
P
E
-
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
T
--
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
--
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
-
K
E
-
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.70
29%
-110
- C2 -
2HYD
3
Y1866_STAAM
A:
[6-576]
--------------------------------------------------------------------------------
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
-
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
N
H
ALT
T
---
D
E
K
V
H
H
L
---
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
-----
F
I
R
Q
Y
L
A
Q
W
-
T
S
N
K
I
L
Y
---
D
----
I
R
K
K
L
Y
N
H
L
-----
Q
A
L
S
A
R
F
Y
A
N
N
--------------
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
-
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
----------
T
V
T
D
I
G
P
I
I
V
I
-
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
-----
R
V
F
Q
L
I
D
E
D
Y
D
--
I
K
N
G
V
----
G
-----
A
--
Q
P
I
E
I
K
Q
G
R
--
I
D
I
D
H
V
S
F
Q
Y
-
N
D
-
N
-
E
A
P
I
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
--
K
--
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
-
P
T
---
A
---
T
D
E
E
V
V
-
E
A
A
K
M
A
N
A
H
D
F
-
I
M
N
L
P
Q
-
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
--
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
--
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
-
R
E
-
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.86
29%
-111
- C2 -
2ONJ
4
Y1866_STAAM
A:
[6-576]
--------------------------------------------------------------------------------
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
-
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
N
H
ALT
T
---
D
E
K
V
H
H
L
---
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
-----
F
I
R
Q
Y
L
A
Q
W
-
T
S
N
K
I
L
Y
---
D
----
I
R
K
K
L
Y
N
H
L
-----
Q
A
L
S
A
R
F
Y
A
N
N
--------------
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
-
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
----------
T
V
T
D
I
G
P
I
I
V
I
-
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
-----
R
V
F
Q
L
I
D
E
D
Y
D
--
I
K
N
G
V
----
G
-----
A
--
Q
P
I
E
I
K
Q
G
R
--
I
D
I
D
H
V
S
F
Q
Y
-
N
D
-
N
-
E
A
P
I
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
--
K
--
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
-
P
T
---
A
---
T
D
E
E
V
V
-
E
A
A
K
M
A
N
A
H
D
F
-
I
M
N
L
P
Q
-
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
--
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
--
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
-
R
E
-
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
81.16
32%
-116
- C2 -
4Q4A
1
Y288_THEMA
B:
[32-590]
-----------------------------------------------------------------------------------
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
-
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
---
F
---
D
-----
L
---
L
----
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
-----
S
L
L
F
W
L
Q
G
K
-
I
M
L
T
L
S
Q
---
D
V
V
F
R
L
R
K
E
L
F
E
K
L
-----
Q
R
V
P
V
G
F
F
D
R
T
--------------
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
-
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
----------
M
V
N
N
L
G
F
A
L
I
S
-
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
-----
R
I
F
E
I
L
D
L
E
E
E
--
K
D
D
P
D
----
A
-----
V
--
E
L
-
R
E
V
R
G
E
--
I
E
F
K
N
V
W
F
S
Y
-
D
--
K
-
K
K
P
V
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
--
R
--
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
-
P
G
---
A
---
T
D
E
E
I
K
-
E
A
A
K
L
T
H
S
D
H
F
-
I
K
H
L
P
E
-
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
--
K
L
M
--
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
--
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
-
D
E
-
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
80.46
32%
-112
- C2 -
3QF4
1
Y288_THEMA
B:
[32-590]
-----------------------------------------------------------------------------------
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
-
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
---
F
---
D
-----
L
---
L
----
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
-----
S
L
L
F
W
L
Q
G
K
-
I
M
L
T
L
S
Q
---
D
V
V
F
R
L
R
K
E
L
F
E
K
L
-----
Q
R
V
P
V
G
F
F
D
R
T
--------------
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
-
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
----------
M
V
N
N
L
G
F
A
L
I
S
-
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
-----
R
I
F
E
I
L
D
L
E
E
E
--
K
D
D
P
D
----
A
-----
V
--
E
L
-
R
E
V
R
G
E
--
I
E
F
K
N
V
W
F
S
Y
-
D
--
K
-
K
K
P
V
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
--
R
--
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
-
P
G
---
A
---
T
D
E
E
I
K
-
E
A
A
K
L
T
H
S
D
H
F
-
I
K
H
L
P
E
-
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
--
K
L
M
--
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
--
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
-
D
E
-
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
79.25
27%
-108
- C2 -
3WMG
4
?
A:
[31-598]
--------------------------------------------------------------------------------------------
I
G
F
I
A
-
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
-
E
---
G
-----
E
---
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
-----
G
S
R
T
A
L
F
G
I
-
A
S
E
R
L
A
R
---
D
----
L
R
V
A
A
F
S
N
L
-----
V
E
Q
D
V
T
Y
F
D
R
R
--------------
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
-
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
-
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
----------
L
V
I
F
C
V
Y
A
L
A
L
-
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
-----
E
L
F
A
M
I
D
R
V
P
Q
--
Y
R
R
P
D
----
P
G
A
E
V
V
T
--
Q
P
-
L
V
L
K
Q
G
--
I
V
F
E
N
V
H
F
R
Y
-
P
T
-
R
M
N
V
E
V
L
--
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
--
W
--
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
--
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
K
-
R
D
---
A
---
T
D
E
E
V
I
-
Q
A
L
R
E
A
N
A
Y
S
F
-
V
M
A
L
P
D
-
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
--
R
M
M
A
S
D
G
V
--
T
S
V
V
I
A
H
R
L
S
T
V
A
R
-
A
--
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
-
S
E
-
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Fugue
77.25
26%
-99
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
-------------------------------------------------------------------------W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
-
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
---
R
---
S
-----
V
---
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
-----
Y
I
S
S
Y
C
I
S
W
-
V
S
G
K
V
V
M
---
T
----
M
R
R
R
L
F
G
H
M
-----
M
G
M
P
V
A
F
F
D
K
Q
--------------
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
-
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
----------
L
I
A
S
L
A
L
A
F
V
L
-
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
-----
T
L
F
A
I
L
D
S
E
Q
E
--
K
D
E
G
K
----
R
-----
V
---
I
-
D
R
A
T
G
D
--
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
P
A
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
--
R
--
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
-
T
E
---
E
Y--
S
R
E
Q
I
E
-
E
A
A
R
M
A
Y
A
M
D
F
-
I
N
K
M
D
N
-
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
Q
--
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
--
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
-
S
E
-
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
76.54
26%
-98
- C2 -
3B60
2
MSBA_SALTY
A:
[23-581]
--------------------------------------------------------------------------------------
F
K
A
G
L
I
V
A
G
I
A
-
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
---
R
---
S
-----
V
---
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
-----
Y
I
S
S
Y
C
I
S
W
-
V
S
G
K
V
V
M
---
T
----
M
R
R
R
L
F
G
H
M
-----
M
G
M
P
V
A
F
F
D
K
Q
--------------
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
-
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
----------
L
I
A
S
L
A
L
A
F
V
L
-
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
-----
T
L
F
A
I
L
D
S
E
Q
E
--
K
D
E
G
K
----------
R
--
V
I
-
D
R
A
T
G
D
--
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
P
A
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
--
R
--
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
-
T
E
E--
Y
---
S
R
E
Q
I
E
-
E
A
A
R
M
A
Y
A
M
D
F
-
I
N
K
M
D
N
-
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
Q
--
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
--
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
-
S
E
-
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
75.16
27%
-103
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[12-572]
---------------------------------------------------------------------------------
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
-
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
---
V
DY
S
D
-----
N
---
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
-----
A
I
R
V
Y
L
M
Q
T
-
S
G
Q
R
I
V
N
---
R
----
L
R
T
S
L
F
S
S
I
-----
L
R
Q
E
V
A
F
F
D
K
T
--------------
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
-
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
----------
L
S
G
N
L
I
V
L
S
V
L
-
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
-----
R
L
W
E
L
L
E
R
E
P
K
--
L
P
F
N
E
----
G
-----
V
I
L
N
E
-
K
S
F
Q
G
A
--
L
E
F
K
N
V
H
F
A
Y
-
P
A
-
R
P
E
V
P
I
F
--
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
PSS
V
---
T
A
E
E
I
Q
-
R
V
A
E
V
A
N
A
V
A
F
-
I
R
N
F
P
Q
-
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
--
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
--
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
-
L
L
S
K
P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.16
28%
-95
- C2 -
3B60
2
MSBA_SALTY
A:
[43-581]
-----------------------------------------------------------------------------------------------------------
F
M
L
S
L
L
K
P
L
L
D
D
G
F
--
G
K
---
T
---
D
-----
R
-----
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
-----
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
----
M
R
R
R
L
F
G
H
M
-----
M
G
M
P
V
A
F
F
D
K
Q
--------------
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
-
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
----------
L
I
A
S
L
A
L
A
F
V
L
-
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
-----
T
L
F
A
I
L
D
S
E
Q
E
----
K
D
E
----
G
-----
K
--
R
V
I
D
R
A
T
G
D
--
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
P
A
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
--
R
--
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
---
S
R
E
Q
I
E
-
E
A
A
R
M
A
Y
A
M
D
F
-
I
N
K
M
D
N
-
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
Q
--
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
--
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
-
S
E
-
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.34
28%
-112
- C2 -
4AYW
3
ABCBA_HUMAN
A:
[54-598]
-------------------------------------------------------------------------------------------
A
A
V
G
F
L
-
T
M
S
S
V
I
-
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
---
V
---
D
-----
Y
-----
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
Q
R
I
V
N
---
R
----
L
R
T
S
L
F
S
S
I
-----
L
R
Q
E
V
A
F
F
D
K
T
--------------
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
-
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----------
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
-
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
-----
R
L
W
E
L
L
E
R
E
P
K
--
L
P
F
N
E
G
V
I
L
N
-----
E
--
K
S
-
F
Q
--
G
A
--
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
-
E
V
P
I
F
--
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
---
P
SSV
T
A
E
E
I
Q
-
R
V
A
E
V
A
N
A
V
A
F
-
I
R
N
F
P
Q
-
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
--
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
--
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.08
28%
-106
- C2 -
4AYX
7
ABCBA_HUMAN
A:
[24-574]
--------------------------------------------------------------------------------------------
A
V
G
F
L
-
T
M
S
S
V
I
-
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
---
V
---
D
-----
Y
-----
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
Q
R
I
V
N
---
R
----
L
R
T
S
L
F
S
S
I
-----
L
R
Q
E
V
A
F
F
D
K
T
--------------
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
-
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----------
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
-
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
-----
R
L
W
E
L
L
E
R
E
P
K
--
L
P
F
N
E
G
V
I
L
N
-----
E
--
K
S
-
F
Q
--
G
A
--
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
-
E
V
P
I
F
--
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
---
P
SSV
T
A
E
E
I
Q
-
R
V
A
E
V
A
N
A
V
A
F
-
I
R
N
F
P
Q
-
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
--
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
--
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
L
L
S
K
P
--
N
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.00
28%
-105
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[24-572]
--------------------------------------------------------------------------------------------
A
V
G
F
L
-
T
M
S
S
V
I
-
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
---
V
---
D
-----
Y
-----
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
Q
R
I
V
N
---
R
----
L
R
T
S
L
F
S
S
I
-----
L
R
Q
E
V
A
F
F
D
K
T
--------------
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
-
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----------
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
-
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
-----
R
L
W
E
L
L
E
R
E
P
K
--
L
P
F
N
E
G
V
I
L
N
-----
E
--
K
S
-
F
Q
--
G
A
--
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
-
E
V
P
I
F
--
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
---
P
SSV
T
A
E
E
I
Q
-
R
V
A
E
V
A
N
A
V
A
F
-
I
R
N
F
P
Q
-
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
--
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
--
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
L
L
S
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.82
28%
-106
- C2 -
4AYT
8
ABCBA_HUMAN
A:
[24-567]
--------------------------------------------------------------------------------------------
A
V
G
F
L
-
T
M
S
S
V
I
-
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
---
V
---
D
-----
Y
-----
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
Q
R
I
V
N
---
R
----
L
R
T
S
L
F
S
S
I
-----
L
R
Q
E
V
A
F
F
D
K
T
--------------
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
-
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----------
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
-
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
-----
R
L
W
E
L
L
E
R
E
P
K
--
L
P
F
N
E
G
V
I
L
N
-----
E
--
K
S
-
F
Q
--
G
A
--
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
-
E
V
P
I
F
--
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
---
P
SSV
T
A
E
E
I
Q
-
R
V
A
E
V
A
N
A
V
A
F
-
I
R
N
F
P
Q
-
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
--
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
--
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.40
27%
-109
- C2 -
4F4C
1
PGP1_CAEEL
A:
[116-703]
--------------------------------------------------------------------------------------------------------
G
S
T
F
L
P
T
-
G
Q
N
Y
T
K
T
D
F
E
H
D
V
---
M
---
N
-----
V
---
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
-----
T
C
Y
L
Y
V
A
E
Q
-
M
N
N
R
L
R
R
---
E
----
F
V
K
S
I
L
R
Q
---------
E
I
S
W
F
D
T
N
--------------
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
-
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
-
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
----------
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
-----
G
I
Y
E
V
L
D
R
K
P
V
--
I
D
S
S
S
----
K
-----
A
G
R
K
D
-
M
K
I
K
G
D
--
I
T
V
E
N
V
H
F
T
Y
-
P
S
R
P
-
D
V
P
I
L
--
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
--
R
--
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
--
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
-
E
G
---
I
---
T
R
E
E
M
V
-
A
A
C
K
M
A
N
A
E
K
F
-
I
K
T
L
P
N
-
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
--
K
A
A
--
K
G
R
--
T
T
I
I
I
A
H
R
L
S
T
I
R
N
-
A
--
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
-
R
A
-
L
M
A
Q
--
Q
G
L
Y
Y
D
L
V
T
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Fugue
70.02
24%
-111
- C2 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
-
A
F
--
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
L
P
T
G
Q
N
Y
T
K
---
T
---
D
-----
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
-----
Q
I
T
V
T
C
Y
L
Y
-
V
A
E
Q
M
N
N
---
R
----
L
R
R
E
F
V
K
S
I
-----
L
R
Q
E
I
S
W
F
D
T
N
--------------
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
-
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
----------
A
S
N
F
I
S
F
A
L
A
F
-
Y
I
G
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
-----
G
I
Y
E
V
L
D
R
K
P
V
--
I
D
S
S
S
----
K
-----
A
--
G
R
-
K
D
M
K
I
K
G
D
I
T
V
E
N
V
H
F
T
Y
P
S
R
-
P
-
D
V
P
I
L
--
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
--
R
--
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
--
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
-
E
G
---
I
---
T
R
E
E
M
V
-
A
A
C
K
M
A
N
A
E
K
F
-
I
K
T
L
P
N
-
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
--
K
A
A
--
K
G
R
--
T
T
I
I
I
A
H
R
L
S
T
I
R
N
-
A
--
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
-
R
A
-
L
M
A
Q
--
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
20
PsiBlast_PDB
69.78
28%
-106
- C2 -
4MYH
-
ATM1_YEAST
A:
[55-577]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
I
G
L
T
-----
I
L
C
Y
G
V
A
R
F
-
G
S
V
L
F
G
----
E
----
L
R
N
A
V
F
A
K
V
A
Q
N
A
I
R
T
V
S
L
Q
T
F
Q
H
L
M
K
LD
L
G
W
H
L
S
RQ
T
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
A
M
V
F
H
I
I
P
I
S
F
E
I
S
V
V
C
G
I
L
T
Y
Q
F
G
--
A
S
F
A
A
I
T
F
S
T
M
L
L
Y
S
I
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
-
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
----------
L
I
F
T
T
A
L
T
A
M
M
-
Y
M
G
C
T
G
V
I
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
K
N
E
V
K
I
K
N
A
E
RP
L
M
L
P
E
----
N
-----
V
--------
P
Y
D
--
I
T
F
E
N
V
T
F
G
Y
-
H
--
P
-
D
R
K
I
L
--
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
--
K
--
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
--
D
T
P
L
F
N
D
T
I
W
E
N
V
K
F
G
R
-
I
D
---
A
---
T
D
E
E
V
I
-
T
V
V
E
K
A
Q
L
A
P
L
-
I
K
K
L
P
Q
-
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
--
D
N
F
--
T
S
G
SR
T
S
V
Y
I
A
H
R
L
R
T
I
A
D
-
A
--
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
-
L
A
M
P
--
G
S
L
Y
R
E
L
W
T
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
62.69
35%
-94
- C2 -
1XEF
3
HLYBP_ECOLX
C:
[2-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
62.15
35%
-90
- C2 -
1XEF
3
HLYBP_ECOLX
B:
[2-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
61.97
35%
-88
- C2 -
2FGJ
2
HLYBP_ECOLX
A:
[8-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
61.94
35%
-92
- C2 -
2FGK
2
HLYBP_ECOLX
B:
[8-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
61.64
35%
-91
- C2 -
2FGJ
2
D:
[8-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
61.50
35%
-92
- C2 -
2FGK
2
D:
[8-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
61.49
35%
-89
- C2 -
1XEF
3
HLYBP_ECOLX
A:
[2-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
60.83
35%
-89
- C2 -
2PMK
1
A:
[4-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
60.80
35%
-91
- C2 -
2FGK
2
HLYBP_ECOLX
A:
[8-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
60.69
35%
-88
- C2 -
2FGJ
2
HLYBP_ECOLX
B:
[8-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
60.59
35%
-87
- C2 -
2FGJ
2
HLYBP_ECOLX
C:
[8-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
60.58
35%
-90
- C2 -
2FGK
2
HLYBP_ECOLX
C:
[8-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
59.88
35%
-88
- C2 -
1XEF
3
D:
[2-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
---
S
V
E
K
V
I
-
Y
A
A
K
L
A
G
A
H
D
F
-
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
C
--
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
53.46
31%
-66
- C2 -
4MKI
4
ECFA2_CALS4
B:
[5-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
--
I
K
V
E
N
V
S
F
I
Y
N
E
G
-
T
-
P
Y
A
T
V
AL
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
---
K
G
K
I
Y
I
N
G
I
D
I
TD
K
--
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
T
V
F
K
D
I
A
F
G
P
-
S
N
L
G-
L
---
S
E
E
E
V
K
-
E
R
V
Y
E
A
M
E
I
V
G
-
I
S
K
-------
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
--
Y
K
M
--
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
--
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
-
R
E
-
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
53.17
31%
-65
- C2 -
4MKI
4
ECFA2_CALS4
A:
[4-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
P
--
I
K
V
E
N
V
S
F
I
Y
N
E
G
-
T
-
P
Y
A
T
V
AL
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
---
K
G
K
I
Y
I
N
G
I
D
I
TD
K
--
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
T
V
F
K
D
I
A
F
G
P
-
S
N
L
G-
L
---
S
E
E
E
V
K
-
E
R
V
Y
E
A
M
E
I
V
G
-
I
S
K
-------
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
--
Y
K
M
--
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
--
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
-
R
E
-
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
47.66
33%
-61
- C2 -
4YMU
2
?
A:
[16-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
--
N
NG
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
-------
E
N
---
I
---
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
--
Q
L
A
--
N
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
-
E
VG
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
-
E
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
46.63
33%
-59
- C2 -
4YMU
2
?
J:
[16-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
--
N
NG
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
-------
E
N
---
I
---
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
--
Q
L
A
--
N
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
-
E
VG
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
-
E
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
45.68
33%
-62
- C2 -
4YMV
1
?
J:
[16-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
--
N
NG
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
-------
E
N
---
I
---
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
--
Q
L
A
--
N
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
-
E
VG
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
-
E
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
45.62
33%
-59
- C2 -
4YMV
1
?
A:
[16-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
--
N
NG
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
-------
E
N
---
I
---
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
--
Q
L
A
--
N
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
-
E
VG
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
-
E
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------