@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0613: (2016-03-17 )
MKAVVIENYGGKEELKEKEVAMPKAGKNQVIVKEAATSINPIDWKLREGYLKQMMDWEFPIILGWDVAGVISEVGEGVTDWKVGDEVFARPETTRFGTYAEYTAVDDHLLAPLPEGISFDEAASIPLAGLTAWQALFDHAKLQKGEKVLIHAGAGGVGTLAIQLAKHAGAEVITTASAKNHELLKSLGADQVIDYKEVNFKDVLSDIDVVFDTMGGQIETDSYDVLKEGTGRLVSIVGISNEDRAKEKNVTATGIWLQPNGEQLKELGKLLANKTIKPIVGATFPFSEKGVFDAHALSETHHAVGKIVISFNK
Atome Classification :
(25 SA)
----.........10.....--...20-......-...30........40........--50...--...------------.------------.60........70........80----.......------.---90.------------------------.---------------------.------------------------.....100.....-..110.......120--....---...130.......140.----......150.......160......--.170.-....-..180........190...------...-.200...------..------.------.-----.210.......220........230-.....---..----------------------.240---.------.-.--...-------.250...-------------------.-------------...260.......270..----.-------------....-280-.......290........300---........310.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
K
A
V
V
IENYG
G
K
E
E
L
K
--
E
K
EV--AMPKAG-KN
Q
V
I
V
K
E
AATSINPI
D
W
K
L
R
E
G
--
Y
L
K
Q
M--MDW------------E------------F
P
I
I
L
G
W
D
V
A
G
V
I
S
E
V
GEGVTDW----KVG
D
E
VF------A---RPE------------------------T---------------------T------------------------RFGT
Y
A
E
YTAVD
D
-
H
L
LAPLPEGISFDEA--ASIP---
L
A
G
L
T
A
W
Q
A
L
F
D
H
A
K
LQ----KG
E
K
V
L
I
H
AGAGG
V
G
T
L
A
I
Q
L
A
K
HA--GA
E
V
I
-
T
TAS-AK
N
H
-
E
L
L
K
SLGADQVIDY------KEV-
N
F
-
K
D
V
L
------
S
D
------
I
------
D
-----
V
V
F
D
TMG
G
Q
IETD-
S
Y
D
V
L
K
EGT-
G
-
R
L
V
S
I
---
V
G----------------------ISNE---D------R-A--KEK-------NV
T
A
T
G
I
-------------------
W
-------------LQP
N
G
E
Q
L
K
E
L
G
K
L
L
A
NK----T-------------IKPI-VGA-TFPFSEKG-VF
D
A
H
A
L
S
E
T
H
----HA
V
G
K
I
V
I
S
FNK
100
HHSearch
95.61
42%
-85
- C1 -
3TQH
3
?
A:
[7-321]
----
M
K
A
I
Q
F
D
Q
F
G
P
P
K
V
L
K
--
L
V
D
T
--
P
T
P
E
Y
R
-
K
N
Q
M
L
I
K
V
H
A
A
S
L
N
P
I
D
Y
K
T
R
N
G
--
S
G
F
V
A
K
K
L
K
N
------------
N
------------
L
P
S
G
L
G
Y
D
F
S
G
E
V
I
E
L
G
S
D
V
N
N
V
----
N
I
G
D
K
V
M
------
G
---
I
A
G
------------------------
F
P--------------------
D
------------------------
H
P
C
C
Y
A
E
Y
V
C
A
S
P
-
D
T
I
I
Q
K
L
E
K
L
S
F
L
Q
A
--
A
S
L
P
---
T
A
G
L
T
A
L
Q
A
L
N
Q
-
A
E
V
K
----
Q
G
D
V
V
L
I
H
A
G
A
G
G
V
G
H
L
A
I
Q
L
A
K
Q
K
--
G
T
T
V
I
-
T
T
A
S
-
K
R
N
H
-
A
F
L
K
A
L
G
A
E
Q
C
I
N
Y
------
H
E
E
-
D
F
-
L
L
A
I
S-----
T
P
------
V
------
D
-----
A
V
I
D
L
V
G
G
D
V
G
I
Q
-
S
I
D
C
L
K
E
-
T
-
G
-
C
I
V
S
V
---
P
T
----------------------
I
T
A
G
---
R
V
I
----
E
V
A
--
K
Q
K
-------
H
R
R
A
F
G
L
-------------------
L
-------------
K
Q
F
N
I
E
E
L
H
Y
L
G
K
L
V
S
E
D
----
K
-------------
L
R
I
E
-
I
S
R
-
I
F
Q
L
S
E
---
A
V
T
A
H
E
L
L
E
T
G
----
H
V
R
G
K
L
V
F
K
V
R
-
1
PsiBlast_PDB
94.47
41%
-84
- C1 -
3TQH
3
?
A:
[8-317]
-----
K
A
I
Q
F
D
Q
F
G
P
P
K
V
L
K
--
L
V
D
T
--
P
T
P
E
Y
R
-
K
N
Q
M
L
I
K
V
H
A
A
S
L
N
P
I
D
Y
K
T
R
N
G
SG
F
V
A
K
K
--
L
K
N
------------
N
------------
L
P
S
G
L
G
Y
D
F
S
G
E
V
I
E
L
G
S
D
V
N
N
V
----
N
I
G
D
K
V
M
------
G
I
A
G
F
P
D
------------------------
H
---------------------
P
--------------------------
C
C
Y
A
E
Y
V
C
A
S
P
-
D
T
I
I
Q
K
L
E
K
L
S
F
L
Q
A
--
A
S
L
P
---
T
A
G
L
T
A
L
Q
A
L
-
N
Q
A
E
V
K
----
Q
G
D
V
V
L
I
H
A
G
A
G
G
V
G
H
L
A
I
Q
L
A
K
Q
K
--
G
T
T
V
I
-
T
T
A
S
-
K
R
N
H
-
A
F
L
K
A
L
G
A
E
Q
C
I
N
Y
------
H
E
E
-
D
F
-
L
L
A
I
------
S
T
P-----
V
------
D
-----
A
V
I
D
L
V
G
G
D
V
G
I
Q
-
S
I
D
C
L
K
E
-
T
-
G
-
C
I
V
S
V
---
P
T
----------------------
I
T
A
G
R
V
I
E
------
V
-
A
--
K
Q
K
-------
H
R
R
A
F
G
L
-------------------
L
-------------
K
Q
F
N
I
E
E
L
H
Y
L
G
K
L
V
S
E
D
----
K
-------------
L
R
I
E
-
I
S
R
-
I
F
Q
L
S
E
---
A
V
T
A
H
E
L
L
E
T
G
----
H
V
R
G
K
L
V
-----
6
PsiBlast_PDB
91.72
41%
-80
- C1 -
4IDE
5
ENOXC_FRAAN
A:
[25-329]
-----
K
A
W
V
Y
S
E
Y
G
K
T
S
D
V
L
K
F
D
P
S
V
--
A
V
P
E
I
K
-
E
D
Q
V
L
I
K
V
V
A
A
S
L
N
P
V
D
F
K
R
A
L
G
--
Y
F
K
D
T
---
D
S
------------
P
------------
L
P
T
I
P
G
Y
D
V
A
G
V
V
V
K
V
G
S
Q
V
T
K
F
----
K
V
G
D
E
V
Y
G
DLNET
A
---
L
V
N
------------------------
P
---------------------
T
------------------------
R
F
G
S
L
A
E
Y
T
A
A
D
E
-
R
V
L
A
H
K
P
K
N
L
S
F
I
E
A
--
A
S
L
P
---
L
A
I
E
T
A
H
E
G
L
-
E
R
A
E
L
S
----
A
G
K
S
V
L
V
L
G
G
A
G
G
V
G
T
H
I
I
Q
L
A
K
H
V
FG
A
S
K
V
A
-
A
T
A
S
-
T
K
K
L
-
D
L
L
R
T
L
G
A
D
L
A
I
D
Y
------
T
K
E
-
N
F
-
E
D
L
P
------
E
K
------
F
------
D
-----
V
V
Y
D
A
V
G
---
E
T
D
K
A
V
K
A
V
K
E
G
--
G
-
K
V
V
T
I
---
V
G
----------------------
P
A
T
P
---------------------------
P
A
I
L
F
-------------------
V
-------------
L
T
S
K
G
S
V
L
E
K
L
K
P
Y
L
E
S
G
----
K
-------------
V
K
P
V
-
L
D
P
-
T
S
P
Y
P
F
T
K
-
V
V
E
A
F
G
Y
L
E
S
S
----
R
A
T
G
K
V
V
V
----
3
PsiBlast_PDB
91.00
41%
-81
- C1 -
4IDB
5
ENOXC_FRAAN
A:
[25-329]
-----
K
A
W
V
Y
S
E
Y
G
K
T
S
D
V
L
K
F
D
P
S
V
--
A
V
P
E
I
K
-
E
D
Q
V
L
I
K
V
V
A
A
S
L
N
P
V
D
F
K
R
A
L
G
--
Y
F
K
D
T
---
D
S
------------
P
------------
L
P
T
I
P
G
Y
D
V
A
G
V
V
V
K
V
G
S
Q
V
T
K
F
----
K
V
G
D
E
V
Y
G
DLNET
A
---
L
V
N
------------------------
P
---------------------
T
------------------------
R
F
G
S
L
A
E
Y
T
A
A
D
E
-
R
V
L
A
H
K
P
K
N
L
S
F
I
E
A
--
A
S
L
P
---
L
A
I
E
T
A
H
E
G
L
-
E
R
A
E
L
S
----
A
G
K
S
V
L
V
L
G
G
A
G
G
V
G
T
H
I
I
Q
L
A
K
H
V
FG
A
S
K
V
A
-
A
T
A
S
-
T
K
K
L
-
D
L
L
R
T
L
G
A
D
L
A
I
D
Y
------
T
K
E
-
N
F
-
E
D
L
P
------
E
K
------
F
------
D
-----
V
V
Y
D
A
V
G
---
E
T
D
K
A
V
K
A
V
K
E
G
--
G
-
K
V
V
T
I
---
V
G
----------------------
P
A
T
P
---------------------------
P
A
I
L
F
-------------------
V
-------------
L
T
S
K
G
S
V
L
E
K
L
K
P
Y
L
E
S
G
----
K
-------------
V
K
P
V
-
L
D
P
-
T
S
P
Y
P
F
T
K
-
V
V
E
A
F
G
Y
L
E
S
S
----
R
A
T
G
K
V
V
V
----
5
PsiBlast_PDB
90.84
41%
-81
- C1 -
4IDD
5
ENOXC_FRAAN
A:
[25-329]
-----
K
A
W
V
Y
S
E
Y
G
K
T
S
D
V
L
K
F
D
P
S
V
--
A
V
P
E
I
K
-
E
D
Q
V
L
I
K
V
V
A
A
S
L
N
P
V
D
F
K
R
A
L
G
--
Y
F
K
D
T
---
D
S
------------
P
------------
L
P
T
I
P
G
Y
D
V
A
G
V
V
V
K
V
G
S
Q
V
T
K
F
----
K
V
G
D
E
V
Y
G
DLNET
A
---
L
V
N
------------------------
P
---------------------
T
------------------------
R
F
G
S
L
A
E
Y
T
A
A
D
E
-
R
V
L
A
H
K
P
K
N
L
S
F
I
E
A
--
A
S
L
P
---
L
A
I
E
T
A
H
E
G
L
-
E
R
A
E
L
S
----
A
G
K
S
V
L
V
L
G
G
A
G
G
V
G
T
H
I
I
Q
L
A
K
H
V
FG
A
S
K
V
A
-
A
T
A
S
-
T
K
K
L
-
D
L
L
R
T
L
G
A
D
L
A
I
D
Y
------
T
K
E
-
N
F
-
E
D
L
P
------
E
K
------
F
------
D
-----
V
V
Y
D
A
V
G
---
E
T
D
K
A
V
K
A
V
K
E
G
--
G
-
K
V
V
T
I
---
V
G
----------------------
P
A
T
P
---------------------------
P
A
I
L
F
-------------------
V
-------------
L
T
S
K
G
S
V
L
E
K
L
K
P
Y
L
E
S
G
----
K
-------------
V
K
P
V
-
L
D
P
-
T
S
P
Y
P
F
T
K
-
V
V
E
A
F
G
Y
L
E
S
S
----
R
A
T
G
K
V
V
V
----
7
PsiBlast_PDB
90.83
41%
-80
- C1 -
4IDF
5
ENOXC_FRAAN
A:
[25-329]
-----
K
A
W
V
Y
S
E
Y
G
K
T
S
D
V
L
K
F
D
P
S
V
--
A
V
P
E
I
K
-
E
D
Q
V
L
I
K
V
V
A
A
S
L
N
P
V
D
F
K
R
A
L
G
--
Y
F
K
D
T
---
D
S
------------
P
------------
L
P
T
I
P
G
Y
D
V
A
G
V
V
V
K
V
G
S
Q
V
T
K
F
----
K
V
G
D
E
V
Y
GDLNET
A
---
L
V
N
------------------------
P
---------------------
T
------------------------
R
F
G
S
L
A
E
Y
T
A
A
D
E
-
R
V
L
A
H
K
P
K
N
L
S
F
I
E
A
--
A
S
L
P
---
L
A
I
E
T
A
H
E
G
L
-
E
R
A
E
L
S
----
A
G
K
S
V
L
V
L
G
G
A
G
G
V
G
T
H
I
I
Q
L
A
K
H
V
FG
A
S
K
V
A
-
A
T
A
S
-
T
K
K
L
-
D
L
L
R
T
L
G
A
D
L
A
I
D
Y
------
T
K
E
-
N
F
-
E
D
L
P
------
E
K
------
F
------
D
-----
V
V
Y
D
A
V
G
---
E
T
D
K
A
V
K
A
V
K
E
G
--
G
-
K
V
V
T
I
---
V
G
----------------------
P
A
T
P
---------------------------
P
A
I
L
F
-------------------
V
-------------
L
T
S
K
G
S
V
L
E
K
L
K
P
Y
L
E
S
G
----
K
-------------
V
K
P
V
-
L
D
P
-
T
S
P
Y
P
F
T
K
-
V
V
E
A
F
G
Y
L
E
S
S
----
R
A
T
G
K
V
V
V
----
2
PsiBlast_PDB
90.02
41%
-86
- C1 -
4IDA
5
ENOXC_FRAAN
A:
[25-329]
-----
K
A
W
V
Y
S
E
Y
G
K
T
S
D
V
L
K
F
D
P
S
V
--
A
V
P
E
I
K
-
E
D
Q
V
L
I
K
V
V
A
A
S
L
N
P
V
D
F
K
R
A
L
G
--
Y
F
K
D
T
---
D
S
------------
P
------------
L
P
T
I
P
G
Y
D
V
A
G
V
V
V
K
V
G
S
Q
V
T
K
F
----
K
V
G
D
E
V
Y
GDLNET
A
---
L
V
N
------------------------
P
---------------------
T
------------------------
R
F
G
S
L
A
E
Y
T
A
A
D
E
-
R
V
L
A
H
K
P
K
N
L
S
F
I
E
A
--
A
S
L
P
---
L
A
I
E
T
A
H
E
G
L
-
E
R
A
E
L
S
----
A
G
K
S
V
L
V
L
G
G
A
G
G
V
G
T
H
I
I
Q
L
A
K
H
V
FG
A
S
K
V
A
-
A
T
A
S
-
T
K
K
L
-
D
L
L
R
T
L
G
A
D
L
A
I
D
Y
------
T
K
E
-
N
F
-
E
D
L
P
------
E
K
------
F
------
D
-----
V
V
Y
D
A
V
G
---
E
T
D
K
A
V
K
A
V
K
E
G
--
G
-
K
V
V
T
I
---
V
G
----------------------
P
A
T
P
---------------------------
P
A
I
L
F
-------------------
V
-------------
L
T
S
K
G
S
V
L
E
K
L
K
P
Y
L
E
S
G
----
K
-------------
V
K
P
V
-
L
D
P
-
T
S
P
Y
P
F
T
K
-
V
V
E
A
F
G
Y
L
E
S
S
----
R
A
T
G
K
V
V
V
----
119
Fugue
90.00
36%
-80
- C1 -
2VN8
3
RT4I1_HUMAN
A:
[18-375]
L
Y
F
Q
S
M
A
W
V
I
D
K
Y
G
K
N
E
V
L
R
--
F
T
Q
N
MM
M
P
I
I
H
Y
-
P
N
E
V
I
V
K
V
H
A
A
S
V
N
P
I
D
V
N
M
R
S
G
--
Y
G
A
T
A
--
L
N
M
------------
K
R
DPLHVKIKGEE
F
P
L
T
L
G
R
D
V
S
G
V
V
M
E
C
G
L
D
V
K
Y
F
----
K
P
G
D
E
V
W
------
A
---
A
V
P
------------------------
P
---------------------
W
------------------------
K
Q
G
T
L
S
E
F
V
V
V
S
G
-
N
E
V
S
H
K
P
K
S
L
T
H
T
Q
A
--
A
S
L
P
---
Y
V
A
L
T
A
W
S
A
I
N
K
V
G
G
L
N
DKNC
T
G
K
R
V
L
I
L
G
A
S
G
G
V
G
T
F
A
I
Q
V
M
K
A
W
--
D
A
H
V
T
-
A
V
C
S
-
Q
D
A
S
-
E
L
V
R
K
L
G
A
D
D
V
I
D
Y
------
K
S
G
-
S
V
-
E
E
Q
L
------
K
S
L
KP---
F
------
D
-----
F
I
L
D
N
V
G
G
S
T
E
T
W
-
A
P
D
F
L
K
K
W
S
G
A
-
T
Y
V
T
L
---
V
T
P
F
L
L
N
M
D
R
LG
I
A
D
G
M
L
Q
T
G
V
T
V
G
S
K
A
---
L
------
K
-
H
--
F
W
K
-------
G
V
H
Y
R
W
A
-------------------
F
-------------
F
M
A
S
G
P
C
L
D
D
I
A
E
L
V
D
A
G
----
K
-------------
I
R
P
V
-
I
E
Q
-
T
F
P
--
F
S
K
-
V
P
E
A
F
L
K
V
E
R
G
----
H
A
R
G
K
T
V
I
N
V
V
-
4
PsiBlast_PDB
89.93
41%
-82
- C1 -
4IDC
5
ENOXC_FRAAN
A:
[25-329]
-----
K
A
W
V
Y
S
E
Y
G
K
T
S
D
V
L
K
F
D
P
S
V
--
A
V
P
E
I
K
-
E
D
Q
V
L
I
K
V
V
A
A
S
L
N
P
V
D
F
K
R
A
L
G
--
Y
F
K
D
T
---
D
S
------------
P
------------
L
P
T
I
P
G
Y
D
V
A
G
V
V
V
K
V
G
S
Q
V
T
K
F
----
K
V
G
D
E
V
Y
GDLNET
A
---
L
V
N
------------------------
P
---------------------
T
------------------------
R
F
G
S
L
A
E
Y
T
A
A
D
E
-
R
V
L
A
H
K
P
K
N
L
S
F
I
E
A
--
A
S
L
P
---
L
A
I
E
T
A
H
E
G
L
-
E
R
A
E
L
S
----
A
G
K
S
V
L
V
L
G
G
A
G
G
V
G
T
H
I
I
Q
L
A
K
H
V
FG
A
S
K
V
A
-
A
T
A
S
-
T
K
K
L
-
D
L
L
R
T
L
G
A
D
L
A
I
D
Y
------
T
K
E
-
N
F
-
E
D
L
P
------
E
K
------
F
------
D
-----
V
V
Y
D
A
V
G
---
E
T
D
K
A
V
K
A
V
K
E
G
--
G
-
K
V
V
T
I
---
V
G
----------------------
P
A
T
P
---------------------------
P
A
I
L
F
-------------------
V
-------------
L
T
S
K
G
S
V
L
E
K
L
K
P
Y
L
E
S
G
----
K
-------------
V
K
P
V
-
L
D
P
-
T
S
P
Y
P
F
T
K
-
V
V
E
A
F
G
Y
L
E
S
S
----
R
A
T
G
K
V
V
V
----
116
HHSearch
86.69
29%
-78
- C1 -
3UOG
2
?
A:
[28-363]
----
M
Q
E
W
S
T
E
T
V
A
-
P
H
D
L
K
--
L
A
E
R
--
P
V
P
E
A
G
-
E
H
D
I
I
V
R
T
L
A
V
S
L
N
Y
R
D
K
L
V
L
E
T
--
G
M
G
----
L
D
L
------------
A
------------
F
P
F
V
P
A
S
D
M
S
G
V
V
E
A
V
G
K
S
V
T
R
F
----
R
P
G
D
R
V
I
------
S
---
T
F
A
------------------------
P
GWLD
G
L
R
P
G
T
GRTPAYETLGG
A
------------------------
H
P
G
V
L
S
E
Y
V
V
L
P
E
-
G
W
F
V
A
A
P
K
S
L
D
A
A
E
A
--
S
T
L
P
---
C
A
G
L
T
A
W
F
A
L
V
E
K
G
H
L
R
----
A
G
D
R
V
V
V
Q
G
T
-
G
G
V
A
L
F
G
L
Q
I
A
K
A
T
--
G
A
E
V
I
-
V
T
S
S
S
R
E
K
L
-
D
R
A
F
A
L
G
A
D
H
G
I
N
R
------
L
E
E
-
D
W
-
V
E
R
V
Y
A
L
T
G
D
R
G
------
A
------
D
-----
H
I
L
E
I
A
G
G
A
G
L
G
Q
-
S
L
K
A
V
A
P
-
D
-
G
-
R
I
S
V
I
---
G
V
----------------------
L
E
G
F
---
E
V
S
G
P
V
G
P
-
L
--
L
L
K
-------
S
P
V
V
Q
G
I
---------------------------------
S
V
G
H
R
R
A
L
E
D
L
V
G
A
V
D
R
L
----
G
-------------
L
K
P
V
-
I
D
M
-
R
Y
K
F
T
E
---
V
P
E
A
L
A
H
L
D
R
G
-----
P
F
G
K
V
V
I
E
F
--
21
PsiBlast_CBE
86.61
34%
-81
- C1 -
2VN8
2
RT4I1_HUMAN
B:
[24-373]
------
A
W
V
I
D
K
Y
G
K
N
E
V
L
R
F
-
T
Q
N
M
--
M
M
P
I
I
H
Y
P
N
E
V
I
V
K
V
H
A
A
S
V
N
P
I
D
V
N
M
R
S
G
--
Y
G
A
T
A
--
L
N
M
K
R
D
P
LHVKIKGE
E
------------
F
P
L
T
L
G
R
D
V
S
G
V
V
M
E
C
G
L
D
V
K
Y
F
----
K
P
G
D
E
V
W
------
A
---
A
V
P
------------------------
P
---------------------
W
------------------------
K
Q
G
T
L
S
E
F
V
V
V
S
G
-
N
E
V
S
H
K
P
K
S
L
T
H
T
Q
A
--
A
S
L
P
---
Y
V
A
L
T
A
W
S
A
I
N
K
V
G
G
L
N
DKNC
T
G
K
R
V
L
I
L
G
A
S
G
G
V
G
T
F
A
I
Q
V
M
K
A
W
--
D
A
H
V
T
-
A
V
C
S
-
Q
D
A
S
-
E
L
V
R
K
L
G
A
D
D
V
I
D
Y
------
K
S
G
-
S
V
-
E
E
Q
L
------
K
S
------
L
KPF---
D
-----
F
I
L
D
N
V
G
G
S
T
E
T
W
-
A
P
D
F
L
K
K
W
S
-
G
A
T
Y
V
T
L
---
V
T
P
F
--------------------
L
L
N
M
---
D
------
R
L
G
--
I
A
D
-------
G
M
L
Q
T
G
V
T
V
G
S
K
A
L
K
H
F
W
K
G
V
H
Y
R
W
A
F
-------------
F
M
A
S
G
P
C
L
D
D
I
A
E
L
V
D
A
G
----
K
-------------
I
R
P
V
-
I
E
Q
-
T
F
P
F
S
K
---
V
P
E
A
F
L
K
V
E
R
G
----
H
A
R
G
K
T
V
I
N
---
8
PsiBlast_PDB
86.21
34%
-80
- C1 -
2VN8
3
RT4I1_HUMAN
A:
[24-373]
------
A
W
V
I
D
K
Y
G
K
N
E
V
L
R
F
-
T
Q
N
M
--
M
M
P
I
I
H
Y
P
N
E
V
I
V
K
V
H
A
A
S
V
N
P
I
D
V
N
M
R
S
G
--
Y
G
A
T
A
--
L
N
M
K
R
DPLHVKIKGE
E
------------
F
P
L
T
L
G
R
D
V
S
G
V
V
M
E
C
G
L
D
V
K
Y
F
----
K
P
G
D
E
V
W
------
A
---
A
V
P
------------------------
P
---------------------
W
------------------------
K
Q
G
T
L
S
E
F
V
V
V
S
G
-
N
E
V
S
H
K
P
K
S
L
T
H
T
Q
A
--
A
S
L
P
---
Y
V
A
L
T
A
W
S
A
I
N
K
V
G
G
L
N
DKNC
T
G
K
R
V
L
I
L
G
A
S
G
G
V
G
T
F
A
I
Q
V
M
K
A
W
--
D
A
H
V
T
-
A
V
C
S
-
Q
D
A
S
-
E
L
V
R
K
L
G
A
D
D
V
I
D
Y
------
K
S
G
-
S
V
-
E
E
Q
L
------
K
S
------
L
KPF---
D
-----
F
I
L
D
N
V
G
G
S
T
E
T
W
-
A
P
D
F
L
K
K
W
S
-
G
A
T
Y
V
T
L
---
V
T
P
F
--------------------
L
L
N
M
---
D
------
R
L
G
--
I
A
D
-------
G
M
L
Q
T
G
V
T
V
G
S
K
A
L
K
H
F
W
K
G
V
H
Y
R
W
A
F
-------------
F
M
A
S
G
P
C
L
D
D
I
A
E
L
V
D
A
G
----
K
-------------
I
R
P
V
-
I
E
Q
-
T
F
P
F
S
K
---
V
P
E
A
F
L
K
V
E
R
G
----
H
A
R
G
K
T
V
I
N
---
101
HHSearch
85.44
33%
-80
- C1 -
2EIH
1
?
A:
[1-342]
----
M
R
A
V
V
M
R
A
R
G
G
P
E
V
L
E
--
V
A
D
L
--
P
V
P
E
P
G
-
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
--
V
A
S
----
P
K
L
------------
P
------------
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
G
F
----
A
P
G
D
E
V
V
------
I
---
N
P
G
LSCGRC
E
R
C
L
A
GEDNLCPRYQILG
E
---------------------
H
------------------------
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
--
A
A
I
P
---
L
T
F
L
T
A
W
Q
M
V
V
D
K
L
G
V
R
----
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
--
G
A
R
V
I
-
A
T
A
G
S
E
D
K
L
-
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
------
T
H
P
-
D
W
-
P
K
E
V
R
R
L
T
GG
K
G
------
A
------
D
-----
K
V
V
D
H
T
G
A
L
Y
F
E
G
-
V
I
K
A
T
A
N
-
G
-
G
-
R
I
A
I
A
---
G
A
----------------------
S
S
G
Y
---
E
GTLPF
A
H
-
V
--
F
Y
R
-------
Q
L
S
I
L
G
--------------------
S
-------------
T
M
A
S
K
S
R
L
F
P
I
L
R
F
V
E
E
G
----
K
-------------
L
K
P
V
-
V
G
Q
-
V
L
P
L
E
A
---
A
A
E
G
H
R
L
L
E
E
R
----
R
V
F
G
K
V
V
L
Q
V
--
17
PsiBlast_PDB
84.25
29%
-83
- C1 -
1WLY
-
CAA43_BURSP
A:
[4-329]
------
A
A
V
I
H
K
K
G
G
P
D
N
F
V
--
W
E
E
V
--
K
V
G
S
P
G
-
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
--------------------------------------
P
P
I
V
V
G
F
E
A
A
A
V
V
E
E
V
G
P
G
V
T
D
F
----
T
V
G
E
R
V
C
------
T
---
C
--------------------------
L
---------------------
P
------------------------
P
L
G
A
Y
S
Q
E
R
L
Y
P
A
-
E
K
L
I
K
V
P
K
D
L
D
L
D
D
V
H
L
A
G
L
M
---
L
K
G
M
T
A
Q
Y
L
L
H
Q
T
H
K
V
K
----
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
H
L
--
G
A
T
V
I
-
G
T
V
S
-
T
E
E
K
A
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
------
S
T
Q
-
D
F
-
A
E
V
V
------
R
E
------
I
T
G
GKGV
D
-----
V
V
Y
D
S
I
G
K
D
T
L
Q
K
-
S
L
D
C
L
R
P
-
R
-
G
-
M
C
A
A
Y
GHA
S
G
----------------------
V
A
D
P
---
I
------
R
-
V
--
V
E
D
LGVRGS
L
F
I
T
R
P
A
L
-------------------
W
H
------------
Y
M
S
N
R
S
E
I
D
E
G
S
K
C
L
F
D
A
V
K
A
G
V
-------------
L
H
S
S
-
V
A
K
-
T
F
P
L
R
E
A
A
-
A
--
A
H
K
Y
M
G
G
R
----
Q
T
I
G
S
I
V
L
----
115
HHSearch
83.52
34%
-71
- C1 -
3GAZ
1
?
A:
[8-336]
----
M
I
A
A
V
V
E
E
A
N
G
--
P
F
V
--
L
R
K
L
--
A
R
P
Q
P
A
-
P
G
Q
V
L
V
Q
I
E
A
S
G
T
N
P
L
D
A
K
I
R
A
G
--
E
A
P
H
---
A
Q
Q
------------
P
------------
L
P
A
I
L
G
M
D
L
A
G
T
V
V
A
V
G
P
E
V
D
S
F
----
R
V
G
D
A
V
F
------
G
---
L
T
G
------------------------
G
VG-------------------
G
------------------------
L
Q
G
T
H
A
Q
F
A
A
V
D
A
-
R
L
L
A
S
K
P
A
A
L
T
M
R
Q
A
--
S
V
L
P
---
L
V
F
I
T
A
W
E
G
L
V
D
R
A
Q
V
Q
----
D
G
Q
T
V
L
I
Q
G
G
G
G
G
V
G
H
V
A
I
Q
I
A
L
A
R
--
G
A
R
V
F
-
A
T
A
R
-
G
S
D
L
-
E
Y
V
R
D
L
G
A
T
P
I
D
A
S
------
R
E
P
E
D
Y
-
A
A
E
H
TAG---
Q
G
------
F
------
D
-----
L
V
Y
D
T
L
G
G
P
V
L
D
A
-
S
F
S
A
V
K
R
-
F
-
G
-
H
V
V
S
C
---
L
G
----------------------
W
G
T
H
---
K
L
A
----
P
-
L
--
S
F
K
-------
Q
A
T
Y
S
G
V
-------------------
F
TL
H
T
L
L
A
NEG---
L
A
H
F
G
E
M
L
R
E
A
D
A
L
V
Q
T
G
----
K
-------------
L
A
P
R
L
D
P
R
-
T
F
S
I
A
E
---
I
G
S
A
Y
D
A
V
L
G
R
NDVP
R
Q
R
G
K
I
A
I
T
V
E
-
109
HHSearch
82.14
29%
-83
- C1 -
3QWB
3
QOR_YEAST
A:
[9-333]
----
Q
K
V
I
L
I
D
E
I
G
G
Y
D
V
I
K
--
Y
E
D
Y
--
P
V
P
S
I
S
-
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
--
I
Y
P
------
C
------------
E
------------
K
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
N
F
----
E
V
G
D
Q
V
A
------
Y
---
I
S
-------------------------------------------------------------------------
N
S
T
F
A
Q
Y
S
K
I
S
S
Q
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
--
K
L
Y
A
A
G
L
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
----
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
--
G
A
H
T
I
-
A
V
A
S
T
D
E
K
L
-
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
------
S
K
E
-
D
I
-
L
R
Q
V
L
K
F
T
NG
K
G
------
V
------
D
-----
A
S
F
D
S
V
G
K
D
T
F
E
I
-
S
L
A
A
L
K
R
-
K
-
G
-
V
F
V
S
F
---
G
N
----------------------
A
S
G
L
---
I
PPFSIT
R
-
L
--
S
P
K
-------
N
I
T
L
V
R
P
-------------------
Q
L
Y
G
Y
I
AD------
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
----
K
-------------
L
N
I
K
-
I
Y
K
-
T
Y
P
L
R
D
---
Y
R
T
A
A
A
D
I
E
S
R
----
K
T
V
G
K
L
V
L
E
I
P
-
117
HHSearch
81.93
30%
-84
- C1 -
1WLY
-
CAA43_BURSP
A:
[2-332]
----
V
M
A
A
V
I
H
K
K
G
G
P
D
N
F
V
--
W
E
E
V
--
K
V
G
S
P
G
-
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
--------------------------------------
P
P
I
V
V
G
F
E
A
A
A
V
V
E
E
V
G
P
G
V
T
D
F
----
T
V
G
E
R
V
C
------
T
---
C
L
P
-----------------------------------------------------------------------
P
L
G
A
Y
S
Q
E
R
L
Y
P
A
-
E
K
L
I
K
V
P
K
D
L
D
L
D
D
V
H
L
A
G
L
M
---
L
K
G
M
T
A
Q
Y
L
L
H
Q
T
H
K
V
K
----
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
H
L
--
G
A
T
V
I
-
G
T
V
S
T
E
E
K
A
-
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
------
S
T
Q
-
D
F
-
A
E
V
V
R
E
I
T
G
G
K
G
------
V
------
D
-----
V
V
Y
D
S
I
G
K
D
T
L
Q
K
-
S
L
D
C
L
R
P
-
R
-
G
-
M
C
A
A
Y
---
G
H
----------------------
A
S
G
V
---
A
D-----
P
I
R
--
V
V
E
-------
D
L
G
V
R
G
S
-------------------
L
F
I
T
RPA
L
W
H
Y
M
SN
R
S
E
I
D
E
G
S
K
C
L
F
D
A
V
K
A
G
----
V
-------------
L
H
S
S
-
V
A
K
-
T
F
P
L
R
E
---
A
A
A
A
H
K
Y
M
G
G
R
----
Q
T
I
G
S
I
V
L
L
P
Q
-
16
PsiBlast_PDB
81.04
33%
-66
- C1 -
3GAZ
1
?
A:
[10-317]
------
A
A
V
V
E
E
A
N
G
P
F
V
L
R
--
K
--
L
--
A
R
P
Q
P
A
-
P
G
Q
V
L
V
Q
I
E
A
S
G
T
N
P
L
D
A
K
I
R
A
G
--
E
A
P
H
A
--
Q
Q
-------------
P
------------
L
P
A
I
L
G
M
D
L
A
G
T
V
V
A
V
G
P
E
V
D
S
F
----
R
V
G
D
A
V
F
------
G
---
L
T
G
------------------------
G
---------------------
V
GG----------------------
L
Q
G
T
H
A
Q
F
A
A
V
D
A
-
R
L
L
A
S
K
P
A
A
L
T
M
R
Q
A
--
S
V
L
P
---
L
V
F
I
T
A
W
E
G
L
V
D
R
A
Q
V
Q
----
D
G
Q
T
V
L
I
Q
G
G
G
G
G
V
G
H
V
A
I
Q
I
A
L
A
R
--
G
A
R
V
F
-
A
T
A
R
-
G
S
D
L
-
E
Y
V
R
D
L
G
A
T
P
I
D
A
S
------
R
E
P
----
E
D
Y
A
------
A
E
H
TAGQG
F
------
D
-----
L
V
Y
D
T
L
G
G
P
V
L
D
A
-
S
F
S
A
V
K
R
-
F
-
G
-
H
V
V
S
C
---
L
G
----------------------
W
G
T
H
---
K
------
L
-
A
P
L
S
F
K
-------
Q
A
T
Y
S
G
V
-------------------
F
TL
H
T
L
L
A
NEG---
L
A
H
F
G
E
M
L
R
E
A
D
A
L
V
Q
T
G
----
K
-------------
L
A
P
R
-
L
D
P
R
T
F
S
I
A
E
I
G
S
A
Y
D
A
-----------------------
22
PsiBlast_CBE
79.92
31%
-70
- C1 -
2EIH
1
?
B:
[1-340]
----
M
R
A
V
V
M
R
A
R
G
G
P
E
V
L
E
--
V
A
D
L
--
P
V
P
E
P
G
-
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
--
V
A
S
P
K
--
L
P
--------------------------
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
G
F
----
A
P
G
D
E
V
V
------
I
---
N
P
G
------------------------
L
---------------------
S
CGRCERCLAGEDNLCPRYQILGEH
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
--
A
A
I
P
---
L
T
F
L
T
A
W
Q
M
V
V
D
K
L
G
V
R
----
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
--
G
A
R
V
I
-
A
T
A
G
-
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
THPDWP
K
E
V
-
R
R
-
L
T
G
G
------
K
G
------
A
------
D
-----
K
V
V
D
H
T
G
A
L
Y
F
E
G
-
V
I
K
A
T
A
N
G
--
G
-
R
-
I
A
I
---
A
G
----------------------
A
S
S
-------------
G
--
Y
E
G
-------
T
L
P
F
A
H
V
-------------------
F
-------------
Y
R
----
Q
L
S
I
L
G
S
T
M
A
S
K
----
S
RLFPILRFVEEGK
L
K
P
V
-
V
G
Q
-
V
L
P
L
--
E
A
-
A
A
E
G
H
R
L
L
E
E
R
----
R
V
F
G
K
V
V
L
----
11
PsiBlast_PDB
79.75
31%
-72
- C1 -
2EIH
1
?
A:
[1-340]
----
M
R
A
V
V
M
R
A
R
G
G
P
E
V
L
E
--
V
A
D
L
--
P
V
P
E
P
G
-
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
--
V
A
S
P
K
--
L
P
--------------------------
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
G
F
----
A
P
G
D
E
V
V
------
I
---
N
P
G
------------------------
L
---------------------
S
CGRC
E
R
C
L
A
GEDNLCPRYQILGEH
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
--
A
A
I
P
---
L
T
F
L
T
A
W
Q
M
V
V
D
K
L
G
V
R
----
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
--
G
A
R
V
I
-
A
T
A
G
-
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
THPD
W
P
K
E
V
-
R
R
-
L
T
G
G
------
K
G
------
A
------
D
-----
K
V
V
D
H
T
G
A
L
Y
F
E
G
-
V
I
K
A
T
A
N
G
--
G
-
R
-
I
A
I
---
A
G
----------------------
A
S
S
-------------
G
--
Y
E
G
-------
T
L
P
F
A
H
V
-------------------
F
-------------
Y
R
----
Q
L
S
I
L
G
S
T
M
A
S
K
----
S
R
L
F
P
I
L
R
F
V
E
E
GK
L
K
P
V
-
V
G
Q
-
V
L
P
L
--
E
A
-
A
A
E
G
H
R
L
L
E
E
R
----
R
V
F
G
K
V
V
L
----
32
PsiBlast_CBE
58.21
35%
-83
- C1 -
3JYN
1
?
A:
[3-218]
-----
K
R
I
Q
F
S
T
V
G
G
P
E
V
L
E
--
Y
V
D
F
--
E
P
E
A
P
G
-
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
--
L
Y
P
A
P
--
F
---------------------------
L
P
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
T
R
F
----
K
V
G
D
R
V
A
------
Y
-----
G
------------------------
T
---------------------
G
------------------------
P
L
G
A
Y
S
E
V
H
V
L
P
E
-
A
N
L
V
K
L
A
D
S
V
S
F
E
Q
A
--
A
A
L
M
---
L
K
G
L
T
V
Q
Y
L
L
R
Q
T
Y
Q
V
K
----
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
A
L
--
G
A
K
L
I
G
T
V
S
S
-
P
E
K
A
-
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
------
S
H
E
-
D
V
A
K
R
V
L
------
E
L
------
T
------
D
GKKCP
V
V
Y
D
G
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
55.93
36%
-74
- C1 -
4RVU
1
?
C:
[5-199]
----
M
H
A
I
E
V
T
E
T
G
G
P
G
V
L
R
--
H
V
D
Q
--
P
Q
P
Q
P
G
-
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
--
Q
Y
P
R
------------------
E
------------
L
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
A
DTAI
S
V
G
D
R
V
V
------
S
------------------------------
A
---------------------
S
------------------------
A
N
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
----
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
--
G
V
R
V
I
-
T
T
V
S
T
A
E
K
A
-
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
------
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
55.66
36%
-73
- C1 -
4RVU
1
?
D:
[5-199]
----
M
H
A
I
E
V
T
E
T
G
G
P
G
V
L
R
--
H
V
D
Q
--
P
Q
P
Q
P
G
-
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
--
Q
Y
P
R
------------------
E
------------
L
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
----AI--
S
V
G
D
R
V
V
------
S
------------------------------
A
---------------------
S
------------------------
A
N
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
----
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
--
G
V
R
V
I
-
T
T
V
S
T
A
E
K
A
-
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
------
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
54.28
36%
-69
- C1 -
4RVU
1
?
B:
[5-200]
----
M
H
A
I
E
V
T
E
T
G
G
P
G
V
L
R
--
H
V
D
Q
--
P
Q
P
Q
P
G
-
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
--
Q
Y
P
R
------------------
E
------------
L
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
A
D
T
AI
S
V
G
D
R
V
V
------
S
------------------------------
A
---------------------
S
------------------------
A
N
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
----
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
--
G
V
R
V
I
-
T
T
V
S
T
A
E
K
A
-
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
------
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
53.95
36%
-68
- C1 -
4RVU
1
?
A:
[5-199]
----
M
H
A
I
E
V
T
E
T
G
G
P
G
V
L
R
--
H
V
D
Q
--
P
Q
P
Q
P
G
-
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
--
Q
Y
P
R
------------------
E
------------
L
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
A
D
T
AI
S
V
G
D
R
V
V
------
S
------------------------------
A
---------------------
S
------------------------
A
N
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
--
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
----
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
--
G
V
R
V
I
-
T
T
V
S
T
A
E
K
A
-
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
------
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------