@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0727: (2016-03-18 )
MCGIVGYIGTNNAKGILLEGLEKLEYRGYDSAGIALQNKELVTVVKEKGRIADLASLVPSDAFGTTGIGHTRWATHGKPNHENAHPHQSKSGRFTIVHNGVIENYTLLKEEYLKNHSFVSDTDTEVIVQLIELFAAELSTKEAFKKALSLLHGSYAICLIDQTNTETLYAAKNKSPLLIGKGENFNVIASDAMAVLKETDEFVEIMDKEIVIVTKDGFTLETLEGEEITRASYKAELDASDIEKGTYPHYMLKEIDEQPAVTRKIIQAYQDEAGEINVDKTIIDEILSSDRIHIVACGTSYHAGLVGKNLIEKMAKIPVEVHVSSEFAYNLPLMSKKPLFIFITQSGETADSRQCLVKVKELGYRTLTLTNVPGSTLDREADHSMYLYAGPEIAVASTKAYTAQISVLAVLAVSLGREIGDEEALNINLAAELGIVATAMEAMVSSKEVIEHIAGEYLATSRNAFFLGRNIDYFVAMEAALKLKEISYIQAEGFASGELKHGTIALIEDGTPVLALITQESINWNIRGNVNEVLARGAKTCIFAMENVAQPGDRFVIPQVHPLLTPLASVIPCQLLAYYAALHRDCDVDKPRNLAKSVTVE
Atome Classification :
(31 SA)
.........10........20........30........40.........50........60..-......70........80........90........100.......110-.......120.......130.......140........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.---..--..---..---------280.........-290.......300.......310.......320......-.-330.......340---.........350.......360..-.---....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540..----...---..----550....-----...560.......570.......580.......590.......600
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MC
G
I
V
G
Y
IGTNNA
K
G
I
L
L
E
G
L
E
K
L
EYRGYDSAG
I
A
L
QN
K
E
-
L
V
T
V
V
K
EKG
R
I
A
D
L
A
S
LVPSDAF-GTTGIGHTRWATHGKPNHENAHPHQSKSG
R
F
T
I
V
HNGVIE
N
Y
T
L
L
K
E
E
Y
-
L
KNHSFVSDT
D
T
E
V
I
V
Q
L
I
E
L
F
A
A
EL
S
T
-
K
E
A
F
K
K
A
L
S
L
LHG
S
Y
A
I
C
L
I
DQTNT
E
T
L
Y
AAKNKS
P
L
L
I
GKGEN
F
N
V
I
A
S
D
A
M
A
V
L
KE
T
D
E
F
V
E
IMDK
E
I
V
I
V
TKDG
F
T
L
E
TLEGEEITRASYKAEL
D
A
S
DIEKGTY
P
H
Y
M
L
K
EIDEQ
P
A
V
T
R
K
I
I
Q
A
Y
QDEA---GE--IN---
V
D
---------
K
--
T
I
I
D
E
I
LSS-D
R
I
H
I
V
A
CGTS
Y
H
A
G
L
V
G
K
N
L
I
E
K
M
AKI
P
V
E
V
H
VSSEFA-Y-NLPLMSKK
P
L
F
-----
I
F
I
TQSGETA
D
S
R
Q
C
L
V
K
V
K
ELG
Y
-
R
---
T
L
T
L
TNVPGSTLDREADH
S
M
Y
L
YAGP
E
I
A
V
A
ST
K
A
Y
T
A
Q
I
S
V
L
A
V
L
A
V
S
L
G
R
EIGDEE
A
L
N
I
N
L
A
A
EL
G
I
V
A
T
A
M
E
A
M
V
S
S
K
E
V
I
E
H
I
A
G
E
Y
L
ATSR
N
A
F
F
LGRN
I
D
Y
F
V
A
M
E
A
A
LKL
K
E
I
S
Y
I
QAEGFASGELKH
G
T
I
A
L
IEDGT
P
V
L
A
L
I
T
QESI
N
W
N
IRG
N
V
N
E
V
L
A
R
G
A
K
T
C
I
F
A
----
M
E
N
---VA----QPGD
R
F
V
-----IPQ
V
H
P
L
L
T
P
L
A
S
V
I
P
C
Q
L
L
A
Y
Y
A
A
L
HRDCDVD
K
P
R
N
L
A
K
SVTVE
21
PsiBlast_CBE
94.96
41%
-96
- C2 -
4AMV
2
GLMS_ECOLI
C:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
2
PsiBlast_PDB
94.93
41%
-94
- C2 -
4AMV
1
GLMS_ECOLI
A:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
22
PsiBlast_CBE
94.74
41%
-94
- C2 -
4AMV
2
GLMS_ECOLI
B:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
3
PsiBlast_PDB
94.23
41%
-92
- C2 -
2J6H
3
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
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S
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L
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I
G
L
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M
G
E
N
F
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L
A
L
L
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V
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R
R
F
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D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
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K
R
Q
D
I
E
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N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AG
F
V
S
----
S
D
N
M
H
I
I
E
----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
23
PsiBlast_CBE
93.81
41%
-92
- C2 -
2J6H
3
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
27
PsiBlast_CBE
93.52
41%
-96
- C2 -
3OOJ
14
GLMS_ECOLI
G:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
---
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
28
PsiBlast_CBE
93.01
41%
-97
- C2 -
3OOJ
1
GLMS_ECOLI
F:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
--------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
25
PsiBlast_CBE
92.97
41%
-88
- C2 -
1JXA
1
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
30
PsiBlast_CBE
92.96
41%
-95
- C2 -
3OOJ
7
GLMS_ECOLI
D:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
------
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
L
G
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
6
PsiBlast_PDB
92.95
41%
-89
- C2 -
1JXA
1
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AG
F
V
S
----
S
D
N
M
H
I
I
E
----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
31
PsiBlast_CBE
92.44
41%
-92
- C2 -
3OOJ
7
GLMS_ECOLI
C:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
-------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
24
PsiBlast_CBE
92.35
41%
-89
- C2 -
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
29
PsiBlast_CBE
92.11
41%
-92
- C2 -
3OOJ
2
GLMS_ECOLI
E:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
A
GF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
26
PsiBlast_CBE
91.17
41%
-93
- C2 -
3OOJ
14
GLMS_ECOLI
H:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
32
PsiBlast_CBE
90.97
41%
-93
- C2 -
3OOJ
7
GLMS_ECOLI
B:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
L
G
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
7
PsiBlast_PDB
90.49
41%
-91
- C2 -
3OOJ
7
GLMS_ECOLI
A:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AG
F
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
1
PsiBlast_PDB
81.25
64%
-116
- C2 -
4S1W
2
?
A:
[5-342]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
H
Y
M
L
K
E
I
H
E
Q
P
A
V
M
R
R
I
I
Q
E
Y
Q
D
A
E
---
G
N
--
L
K
---
I
D
---------
Q
--
D
I
I
N
D
V
K
E
A
-
D
R
I
Y
V
I
A
A
G
T
S
Y
H
A
G
L
V
G
K
E
F
L
E
K
W
A
G
V
P
T
E
V
H
V
A
S
E
F
V
-
Y
-
N
M
P
L
L
S
E
K
P
L
F
-----
V
Y
I
S
Q
S
G
E
T
A
D
S
R
A
V
L
V
E
T
N
K
L
G
H
-
K
---
S
L
T
I
T
N
V
A
G
S
T
L
S
R
E
A
D
H
T
L
L
L
H
A
G
P
E
I
A
V
A
S
T
K
A
Y
T
A
Q
I
A
V
L
S
I
L
S
Q
I
V
A
K
E
H
--
E
A
--
D
I
D
L
L
R
E
L
A
K
V
T
T
A
I
E
A
I
V
D
D
A
P
I
M
E
Q
I
A
T
D
F
L
E
T
T
R
N
A
F
F
I
G
R
T
I
D
Y
N
V
S
L
E
G
A
L
K
L
K
E
I
S
Y
I
Q
A
E
G
F
A
G
G
E
L
K
H
G
T
I
A
L
I
E
D
G
T
P
V
V
A
L
A
T
Q
E
N
V
N
L
S
I
R
G
N
V
K
E
V
V
A
R
G
A
H
P
C
I
I
S
----
M
E
G
---
L
E
----
K
E
G
D
T
Y
V
-----
I
P
H
V
H
E
L
L
T
P
L
V
S
V
V
A
L
Q
L
I
S
Y
Y
A
A
L
H
R
D
----------------
12
PsiBlast_PDB
67.66
35%
-102
- C2 -
2V4M
2
GFPT1_HUMAN
A:
[13-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
---------
G
R
--
V
N
---
F
D
DYTVNLGGL
K
--
D
H
I
K
E
I
Q
R
C
-
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
-
N
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
-
L
---
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
-
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
DKED
T
E
T
---
I
K
----
N
T
K
R
T
I
K
-----
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
------------
42
PsiBlast_CBE
66.84
35%
-99
- C2 -
2PUT
4
GFA1_CANAL
B:
[4-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
D
------
S
A
F
N
T
M
R
---
G
R
--
I
D
---
F
E
NC
V
V
T
L
GGL
K
--
S
W
L
S
T
I
R
R
C
-
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
-------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
-
L
---
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
N
S
S
L
N
D
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
K
H
G
I
L
A
L
V
D
E
D
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
R
D
G
R
P
I
V
I
C
----
N
E
G
---
D
A
----
I
I
S
N
D
K
V
H
T
T
L
E
V
P
E
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
34
PsiBlast_CBE
66.82
35%
-104
- C2 -
2V4M
3
GFPT1_HUMAN
C:
[16-367]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
---------
G
R
--
V
N
---
F
D
D
Y
T
V
N
LGGL
K
--
D
H
I
K
E
I
Q
R
C
-
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
-
N
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
-
L
---
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
-
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
DKED
T
E
T
---
I
K
----
N
T
K
R
T
I
K
-----
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
---------
8
PsiBlast_PDB
63.83
41%
-94
- C2 -
1MOS
6
GLMS_ECOLI
A:
[2-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
--
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AG
F
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
9
PsiBlast_PDB
63.77
41%
-95
- C2 -
1MOQ
9
GLMS_ECOLI
A:
[3-368]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
--
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AG
F
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
5
PsiBlast_PDB
63.64
41%
-95
- C2 -
2VF5
1
GLMS_ECOLI
X:
[243-608]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AGF
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
54
HHSearch
62.76
41%
-96
- C2 -
1MOQ
9
GLMS_ECOLI
A:
[4-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVD
L
S
--
E
L
--------------
G
P-
N
A
D
E
L
L
S
K
V
-
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
---
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
-
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
---
A
G
F
V
S
S
D
N
M
H
I
I
E
-----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
10
PsiBlast_PDB
62.66
41%
-90
- C2 -
1MOR
1
GLMS_ECOLI
A:
[3-368]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
-
R
I
S
H
---
G
Q
--
V
D
---
L
S
---------
E
LG
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
--
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
AG
F
V
S
----
S
D
N
M
H
I
I
E----
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
36
PsiBlast_CBE
62.56
35%
-97
- C2 -
2PUW
2
GFA1_CANAL
B:
[4-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
D
------
S
A
F
N
T
M
R
---
G
R
--
I
D
---
F
E
N
C
V
V
T
L
GGL
K
--
S
W
L
S
T
I
R
R
C
-
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
-------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
-
L
---
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
N
S
S
---
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
-----------
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
R
D
G
R
P
I
V
I
C
----
N
E
G
---
D
-----------
V
H
T
T
L
E
V
P
E
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
18
PsiBlast_PDB
62.09
35%
-95
- C2 -
2PUW
3
GFA1_CANAL
A:
[4-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
D
------
S
A
F
N
T
M
R
---
G
R
--
I
D
---
F
E
N
C
V
V
T
L
GGL
K
--
S
W
L
S
T
I
R
R
C
-
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
-------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
-
L
---
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
N
S
S
---
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
---------
E
D
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
R
D
G
R
P
I
V
I
C
----
N
E
G
---
D
A
----
I
I
S
N
D
K
V
H
T
T
L
E
V
P
E
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
13
PsiBlast_PDB
61.22
35%
-97
- C2 -
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
---------
G
R
--
V
N
---
F
D
DYTVNLGGL
K
--
D
H
I
K
E
I
Q
R
C
-
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
-
N
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
-
L
---
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
-
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
KED
T
E
T
---
I
K
----
N
T
K
R
T
I
K
-----
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
49
HHSearch
60.96
34%
-96
- C2 -
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
N
F
D
---
D
Y
--
T
V
NLG
G
L
---------
K
--
D
H
I
K
E
I
Q
R
C
-
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
-
D
-
R
N
T
P
V
F
R
D
D
V
C
-----
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
-
L
---
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
-
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
----
D
K
E
---
D
T
E
T
I
K
N
T
K
R
T
I
K
-----
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
14
PsiBlast_PDB
60.61
35%
-94
- C2 -
2ZJ4
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
---------
G
R
--
V
N
---
F
D
DYTVNLGGL
K
--
D
H
I
K
E
I
Q
R
C
-
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
-
N
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
-
L
---
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
-
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
DKED
T
E
T
---
I
K
----
N
T
K
R
T
I
K
-----
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
79
Fugue
38.62
40%
-67
* C2 *
1MOQ
4
?
?:
[3-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
---
Q
V
DL
S
E
---
L
G
---------
P
--
N
A
D
E
L
L
S
K
V
-
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
-
Y
R
K
S
A
V
R
R
-
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
---
G
YL
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------