@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0768: (2016-03-18 )
MKKVLLAILSMVLLLSLAACGGSSDSSKDKNGKEEIVMWGSWSGDQIKQLEKQIDSYNKSQDKYKVKYVMQENVEEKLLTGIAGGELPDIIMWDRYQTALYAPKGVLEPLDKLVKEDNLKMDDFYEESVKEMTYSDKLYGLPLLNDNRILFYNKKLLQEAGVKPPTTWDELATAAQKTTKWDGNKMTQAGMSLQDVGLFNLYLMQAGGELVTSDNKETAFNSEQGLEVLNYWDKMQNDLKVYQRGFDDGSDAFAAGKEAMTYNGPWALADYNKVEDLDYGVVEPPKGPNGDKGAIMGGFGLVMPKQAEHKDGAWDFMKWWTTKPENGVEFAKISGWLPANKIAAEDEYFTKDPNYSVFVNTMKYAKIRPTVAGYADVEGLAMKPQFEKFMNGNISAEKALSQAEKEGNQILKEERDK
Atome Classification :
(20 SA)
.........10........20........30.......--.40...---.-.-...50........-60.....--..---------.70-------..--.---......80...---.-....90.-.-....-..100....-...110......-.120.......130-....----...140.......150.......160---.-......170.....-..180-.----.......--------190---.------...----..---.---..------200........-210-...------....220.......230...--...----.240...-.------...--250--.-------........260......-.270---.--.----.----..-..280....---....-290-.---.-......300-........310.......-320.......330........340-..----....-..350.......360.......370-.......380...--------....390--..-.....400.......410.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
V
L
L
A
I
L
S
M
V
L
L
L
S
L
A
ACGGSSDSSKDKNGK
E
E
I
V
M
--
W
GSWS
G
---
D
-
Q
-
I
K
Q
L
E
K
Q
I
D
SYNK-SQD
K
Y
K
V
--
K
Y
---------
V
M
--------
Q
E--N---
V
E
E
K
L
L
T
G
IAG---G-ELP
D
I
I
M
-W-DR
Y
Q
-
T
ALYAP
K
G
V
-
L
E
P
L
D
K
L
V
K
EDN-LK
M
D
D
F
Y
E
E
S
V
K
EM-TYSD----KLYGLPLLND
N
R
I
L
F
Y
N
K
K
L
L
Q
EAGV---K-PPT
T
W
D
E
L
A
T
A
A
Q
K-TTKW--D----GNKMTQA--------G-----M------S
L
Q
----
D
V
---
G
---
L
F
------
N
-
L
Y
L
M
QAG
G
E
-
L
VT-SDN------KETAFN
S
E
QG
L
E
V
L
N
Y
W
D
K
M
--
Q
N
D
----
L
K
V
Y
Q
RG-F------DDG--S----
D
-------
A
F
AAGKEAMTYNGPWAL-ADYN---K--V----E----DL-DYGV-VEPP---KGPN-G-D-K---G-
A
I
MGGFGL--VMPKQAEHKDG
A
W
D
F
M
K
W
-WTTKPENGV
E
F
A
-KISGWLPANK--IA----AEDE-YFTKDPN
Y
S
V
F
V
NT
M
K
Y
A
K
IRPTVA-GYADVEGLAM
K
P
Q
--------
F
E
K
F
MNG--NI-
S
A
E
K
A
L
S
Q
A
E
KE
G
N
Q
I
L
K
E
ERDK
26
HHSearch
88.85
26%
-46
- C1 -
1EU8
9
MALE_THELN
A:
[2-407]
-------------------------------
E
E
G
K
I
V
F
--
A
V
G
G
A
P
---
N
-
E
-
I
E
Y
W
K
G
V
I
A
E
F
E
K
-
K
Y
P
G
V
T
V
--
E
L
---------
K
R
--------
Q
A
T-
D
T
E
Q
R
R
L
D
L
V
N
A
L
R
G
K--
S
-
S
D
P
D
V
F
L
-
M
-
D
V
A
W
-
L
G
Q
F
I
A
S
G
W
-
L
E
P
L
D
D
Y
V
Q
K
D
N
-
Y
D
L
S
V
F
F
Q
S
V
I
N
L
A
D
K
Q
G
G
----
K
L
Y
A
L
P
V
Y
I
D
A
G
L
L
Y
Y
R
K
D
L
L
E
K
Y
G
Y
---
S
K
P
P
E
T
W
Q
E
L
V
E
M
A
Q
K
-
I
Q
S
G
E
-
R
ETNP
N
F
W
------------
G
-----
F
------
V
W
Q
----
G
K
QY
E
G
L
V
C
D
F
------
V
-
E
Y
V
Y
S
N
G
G
S
-
L
G
E
F
K
D
G
K
-----
W
V
P
T
L
N
K
P
E
N
V
E
A
L
Q
F
M
V
D
L
--
I
H
K
----
Y
K
I
S
P
P
N
-
T
YTEMTE
E
P
V
--
R
----
L
-------
M
F
Q
Q
G
N
A
A
F
E
R
N
W
P
Y
A
W
-
G
L
H
N
---
A
DD
S
P---
V
----
K
G
-
K
V
G
V
-
A
P
L
P
---
H
F
P
G
-
H
-
K
-
S
---
A
-
A
T
L
G
G
W
H
I
--
G
I
S
K
Y
S
D
N
K
A
L
A
W
E
F
V
K
F
-
V
E
S
-
Y
S
V
Q
K
G
F
A
-
M
N
L
G
W
N
P
G
R
V
--
D
V
----
Y
D
D
P
A
V
V
S
K
S
P
H
L
K
E
L
R
A
V
F
E
N
A
V
P
R
P
I
V
P
-
Y
Y
P
Q
L
S
-
E
I
I
Q
K
Y
--------
V
N
S
A
L
A
G
--
K
I
-
S
P
Q
E
A
L
D
K
A
Q
K
E
A
E
E
L
V
K
Q
----
13
PsiBlast_PDB
85.09
23%
-47
- C1 -
3UOR
-
?
A:
[27-415]
--------------------------------
K
T
T
V
R
F
--
W
A
M
--
G
---
K
-
E
-
A
E
V
V
A
E
L
V
A
D
F
E
K
-
Q
N
P
T
I
H
V
D
V
Q
N
---------
I
P
--------
M
T
--
A
---
A
H
E
K
L
L
T
A
F
A
A
---
D
-
G
L
P
D
V
C
Q
-
L
-
G
N
T
W
-
L
P
E
F
A
L
L
D
T
-
L
E
P
M
Q
P
Y
V
A
R
S
K
-
I
V
D
P
A
D
Y
F
P
G
V
W
D
T
-
N
L
V
D
G---
T
L
Y
G
V
P
W
Y
V
D
T
R
L
L
F
Y
R
K
D
L
L
R
E
A
G
Y
S--
Q
-
M
P
K
T
W
A
E
M
E
Q
V
M
A
A
-
I
K
R
K
--
V
----
G
P
D
R
Y
A
I
--------
L
-----
M
------
P
L
N
----
E
F
---
E
---
Q
Q
------
L
-
S
F
A
L
Q
Q
D
D
R
-
L
L
R
-
D
H
D
------
N
Y
G
N
F
R
G
A
G
F
R
K
A
L
G
F
Y
D
N
M
--
Y
Q
Q
GWA-
P
K
V
S
E
T
Q
-
V
------
S
N
V
--
W
----
Y
-------
E
F
F
N
G
Y
Y
A
F
Y
L
S
G
P
W
N
V
-
R
E
F
K
---
L
--
R
----
Q
PPGM
E
G
-
N
W
G
T
-
A
-
P
L
---
P
G
P
N
-
G
-
L
-
G
---
A
-
G
I
A
G
G
S
S
L
--
V
I
F
K
S
S
Q
H
K
D
A
S
W
K
L
I
E
--
Y
L
S
Q
P
Q
V
Q
A
R
F
H
-
A
I
I
G
D
L
P
P
R
R
--
S
T
----
W
K
L
P
-
S
L
A
N
D
A
L
A
H
A
F
G
D
Q
L
E
R
V
K
A
T
P
K
V
L
-
E
W
E
R
I
V
Q
-
E
M
R
L
V
--------
T
E
R
V
V
R
G
--
G
Q
-
S
H
D
A
A
V
Q
E
L
D
Q
R
V
D
E
I
L
A
K
R
R
--
2
PsiBlast_PDB
82.80
27%
-52
- C1 -
4R9F
1
?
A:
[41-405]
---------------------------------
K
Q
V
V
L
T
L
W
Y
P
W
A
G
P
D
G
D
-
A
-
V
V
S
L
A
K
E
---
Y
S
K
-
T
H
P
N
V
Q
I
--
K
A
Q
M
V
SGAGIA
A
T
--------
Q
G
--
G
---
G
Q
G
K
F
L
S
A
V
A
A
---
G
-
N
P
P
D
L
V
L
Y
W
-
G
Q
D
A
-
L
P
G
L
A
D
Q
G
A
-
I
I
P
L
D
D
Y
L
K
D
---
V
D
T
S
K
F
F
E
A
A
Y
N
A
M
-
K
Y
K
G
----
K
I
Y
G
L
P
E
M
V
N
V
R
V
L
F
W
N
K
D
L
F
K
Q
A
G
L
DPN
T
-
P
P
K
T
I
A
E
L
D
Q
M
A
A
K
-
L
T
K
T
--
K
----
N
G
T
I
E
Q
M
GFIPWIGQ
G
-----
V
------
P
H
V
----
M
A
---
G
---
V
F
------
G
-
T
S
L
V
D
S
N
G
N
-
P
I
L
-
S
P
D
------
K
N
P
Q
L
L
N
L
L
K
W
E
V
-
S
Y
S
D
K
Y
G-
A
M
N
----
I
N
K
F
I
A
G
-
M
------
S
Q
N
--
S
SQAN
D
-------
P
F
V
L
G
K
V
A
M
M
I
S
G
E
W
Q
I
N
A
N
K
Q
---
Y
--
N
----
P
----
K
L
-
N
F
G
V
-
G
P
I
P
---
Q
A
P
G
-
G
-
K
-
P
---
M
P
S
L
M
D
G
N
T
W
--
M
I
P
K
G
S
K
H
P
Q
E
A
M
D
F
I
K
--
W
T
M
D
P
Q
R
I
A
D
T
A
D
K
V
Y
N
I
A
P
I
V
E
---
A
----
A
K
I
Q
-
K
L
N
N
D
P
Y
F
K
E
V
L
N
V
A
Q
K
G
S
I
Y
Y
T
P
A
---------------------------------------------------------
23
HHSearch
81.93
22%
-55
- C1 -
3UOR
-
?
A:
[27-415]
--------------------------------
K
T
T
V
R
F
--
W
A
M
G
K
------
E
-
A
E
V
V
A
E
L
V
A
D
F
E
K
-
Q
N
P
T
I
H
V
--
D
V
---------
Q
N
--------
I
P
MT
A
---
A
H
E
K
L
L
T
A
F
A
A
---
D
-
G
L
P
D
V
C
Q
-
L
-
G
N
T
W
-
L
P
E
F
A
L
L
D
T
-
L
E
P
M
Q
P
Y
V
A
R
S
K
I
V
D
P
A
D
Y
F
P
G
V
W
D
T
N
-
L
V
D
G
----
T
L
Y
G
V
P
W
Y
V
D
T
R
L
L
F
Y
R
K
D
L
L
R
E
A
G
Y
---
S
Q
M
P
K
T
W
A
E
M
E
Q
V
M
A
A
-
I
K
R
K
V
G
P
----
D
R
Y
------------
A
-----
I
------
L
M
P
----
L
N
---
E
F
E
-
Q
Q
------
L
-
S
F
A
L
Q
Q
D
D
R
-
L
L
R
-
D
H
D
------
N
Y
G
N
F
R
G
A
G
F
R
K
A
L
G
F
Y
D
N
M
--
Y
Q
Q
----
G
W
A
P
K
V
S
-
E
TQV---
S
N
V
--
W
----
Y
-------
E
F
F
N
G
Y
Y
A
F
Y
L
S
G
P
W
N
V
-
R
E
F
K
---
L
--
R
QPPG
M
----
E
G
-
N
W
G
T
-
A
P
L
P
---
G
P
N
G
-
L
---
G
---
A
-
G
I
A
G
G
S
S
L
--
V
I
F
K
S
S
Q
H
K
D
A
S
W
K
L
I
E
Y
-
L
S
Q
-
P
Q
V
Q
A
R
F
H
-
A
I
I
G
D
L
P
P
R
R
--
S
T
----
W
K
L
P
-
S
L
A
N
D
A
L
A
H
A
F
G
D
Q
L
E
R
V
K
A
T
P
K
V
L
-
E
W
E
R
I
V
-
Q
E
M
R
L
V
--------
T
E
R
V
V
R
G
--
G
Q
-
S
H
D
A
A
V
Q
E
L
D
Q
R
V
D
E
I
L
A
K
R
R
--
9
PsiBlast_PDB
80.69
27%
-38
- C1 -
3K01
1
?
A:
[30-410]
-----------------------------------
V
T
F
--
W
D
T
S
N
E
---
A
-
E
-
K
A
T
Y
Q
A
L
A
E
G
F
E
K
-
E
H
P
K
V
D
V
--
K
Y
---------
V
N
V
PFG----
E
A
--
N
---
A
K
F
K
N
A
A
G
G
N
S
---
G
-
A
-
P
D
V
M
R
-
T
-
E
V
A
W
-
V
A
D
F
A
S
I
G
Y
-
L
A
P
L
D
G
T
P
A
L
D
D
---
G
S
D
H
L
P
Q
A
A
A
S
T
-
R
Y
E
G
----
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
---
E
-
V
P
G
S
V
A
E
L
K
T
A
A
A
E
-
I
T
E
----------
K
T
G
A
T
--------
G
-----
L
------
Y
L
R
GD--
D
P
---
Y
---
W
F
------
L
-
P
Y
L
Y
G
E
G
G
D
-
L
V
D
-
E
K
N
------
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
----
R
V
--
I
K
D
----
L
V
D
S
K
A
A
-
I
------
T
D
A
--
S
----
D
G
W
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
P
W
A
I
-
E
D
V
K
A
GA
R
--
F
----
K
----
D
A
G
N
L
G
V
-
A
P
V
P
---
A
G
S
A
-
G
---
Q
---
G
-
S
P
Q
G
G
W
N
L
--
S
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
A
K
V
Q
Q
Q
T
T
E
-
K
L
S
-
L
L
P
T
R
T
--
S
V
----
Y
E
V
P
-
S
V
A
D
N
E
M
V
K
F
F
K
P
A
V
D
K
A
V
E
R
P
W
I
A
E
G
N
A
L
F
E
P
I
R
L
--
Q
--------
M
A
N
V
L
S
G
--
E
T
-
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
K
D
----
19
PsiBlast_PDB
80.20
24%
-29
- C1 -
4AQ4
5
UGPB_ECOLI
A:
[8-412]
-----------------------------------
I
P
F
--
W
H
S
M
E
G
---
E
-
L
-
G
K
E
V
D
S
L
A
Q
R
F
N
A
-
E
N
P
D
Y
K
I
--
V
P
---------
T
Y
--------
K
G
--
N
---
Y
E
Q
N
L
S
A
G
I
A
A
F
R
T
G
-
N
A
P
A
I
L
Q
-
V
-
Y
E
V
G
-
T
A
T
M
M
A
S
K
A
-
I
K
P
V
Y
D
V
F
K
E
A
G
-
I
Q
F
D
E
S
Q
F
V
P
T
V
S
G
-
Y
Y
S
D
SKTG
H
L
L
S
Q
P
F
N
S
S
T
P
V
L
Y
Y
N
K
D
A
F
K
K
A
G
L
DPE
Q
-
P
P
K
T
W
Q
D
L
A
D
Y
A
A
K
--
L
K
A
--
S
----
G
M
K
C
G
Y
A
--------
S
G
WQGW
I
------
Q
L
E
----
N
F
---
S
---
A
W
------
N
-
G
L
P
F
A
S
K
N
N
-
G
F
D
-
G
T
D
------
A
V
L
E
F
N
K
P
E
Q
V
K
H
I
A
M
L
E
E
M
N
K
K
G
D
----
F
S
Y
V
G
R
K
--------
D
E
S
--
T
----
E
-------
K
F
Y
N
G
D
C
A
M
T
T
A
S
S
G
S
L
-
A
N
I
R
---
E
--
Y
----
A
----
K
F
-
N
Y
G
V
-
G
M
M
P
YDA
D
A
K
D
-
A
-
P
-
Q
---
N
-
A
I
I
G
G
A
S
L
W
V
M
Q
G
K
D
K
E
T
Y
T
G
V
A
K
F
L
D
--
F
L
A
K
P
E
N
A
A
E
W
H
-
Q
K
T
G
Y
L
P
I
T
K
--
A
A
Y
D
L
T
R
E
Q
G
-
F
Y
E
K
N
P
G
A
D
T
A
T
R
Q
M
L
N
K
P
P
L
P
F
T
K
-
G
L
R
----
L
G
N
M
P
Q
I
R
V
I
V
D
E
E
L
E
S
V
W
T
G
--
K
K
-
T
P
Q
Q
A
L
D
T
A
V
E
R
G
N
Q
L
L
R
R
----
11
PsiBlast_PDB
80.14
27%
-37
- C1 -
3K00
1
?
A:
[27-407]
-----------------------------------
V
T
F
--
W
D
T
S
N
E
---
A
-
E
-
K
A
T
Y
Q
A
L
A
E
G
F
E
K
-
E
H
P
K
V
D
V
--
K
Y
---------
V
N
V
P
FG----
E
A
--
N
---
A
K
F
K
N
A
A
G
G
N
S
---
G
-
A
-
P
D
V
M
R
-
T
-
E
V
A
W
-
V
A
D
F
A
S
I
G
Y
-
L
A
P
L
D
G
T
P
A
L
D
D
---
G
S
D
H
L
P
Q
A
A
A
S
T
-
R
Y
E
G
----
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
---
E
-
V
P
G
S
V
A
E
L
K
T
A
A
A
E
-
I
T
E
----------
K
T
G
A
T
--------
G
-----
L
------
Y
L
R
GD--
D
P
---
Y
---
W
F
------
L
-
P
Y
L
Y
G
E
G
G
D
-
L
V
D
-
E
K
N
------
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
----
R
V
--
I
K
D
----
L
V
D
S
K
A
A
-
I
------
T
D
A
--
S
----
D
G
W
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
P
W
A
I
-
E
D
V
K
A
GA
R
--
F
----
K
----
D
A
G
N
L
G
V
-
A
P
V
P
---
A
G
S
A
-
G
---
Q
---
G
-
S
P
Q
G
G
W
N
L
--
S
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
A
K
V
Q
Q
Q
T
T
E
-
K
L
S
-
L
L
P
T
R
T
--
S
V
----
Y
E
V
P
-
S
V
A
D
N
E
M
V
K
F
F
K
P
A
V
D
K
A
V
E
R
P
W
I
A
E
G
N
A
L
F
E
P
I
R
L
--
Q
--------
M
A
N
V
L
S
G
--
E
T
-
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
K
D
----
12
PsiBlast_PDB
79.57
27%
-36
- C1 -
3K02
2
?
A:
[27-407]
-----------------------------------
V
T
F
--
W
D
T
S
N
E
---
A
-
E
-
K
A
T
Y
Q
A
L
A
E
G
F
E
K
-
E
H
P
K
V
D
V
--
K
Y
---------
V
N
V
P
FG----
E
A
--
N
---
A
K
F
K
N
A
A
G
G
N
S
---
G
-
A
-
P
D
V
M
R
-
T
-
E
V
A
W
-
V
A
D
F
A
S
I
G
Y
-
L
A
P
L
D
G
T
P
A
L
D
D
---
G
S
D
H
L
P
Q
A
A
A
S
T
-
R
Y
E
G
----
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
---
E
-
V
P
G
S
V
A
E
L
K
T
A
A
A
E
-
I
T
E
----------
K
T
G
A
T
--------
G
-----
L
------
Y
L
R
GD--
D
P
---
Y
---
W
F
------
L
-
P
Y
L
Y
G
E
G
G
D
-
L
V
D
-
E
K
N
------
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
----
R
V
--
I
K
D
----
L
V
D
S
K
A
A
-
I
------
T
D
A
--
S
----
D
G
W
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
P
W
A
I
-
E
D
V
K
A
GA
R
--
F
----
K
----
D
A
G
N
L
G
V
-
A
P
V
P
---
A
G
S
A
-
G
---
Q
---
G
-
S
P
Q
G
G
W
N
L
--
S
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
A
K
V
Q
Q
Q
T
T
E
-
K
L
S
-
L
L
P
T
R
T
--
S
V
----
Y
E
V
P
-
S
V
A
D
N
E
M
V
K
F
F
K
P
A
V
D
K
A
V
E
R
P
W
I
A
E
G
N
A
L
F
E
P
I
R
L
--
Q
--------
M
A
N
V
L
S
G
--
E
T
-
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
K
D
----
1
PsiBlast_PDB
79.45
28%
-48
- C1 -
4R9G
5
?
A:
[42-405]
----------------------------------
Q
V
V
L
T
L
W
Y
P
W
A
G
P
D
G
D
-
A
-
V
V
S
L
A
K
E
---
Y
S
K
-
T
H
P
N
V
Q
I
--
K
A
---------
Q
M
V
S
GAGIAA-----------
K
F
L
S
A
V
A
A
---
G
-
N
P
P
D
L
V
L
Y
W
-
G
Q
D
A
-
L
P
G
L
A
D
Q
G
A
-
I
I
P
L
D
D
Y
L
K
D
---
V
D
T
S
K
F
F
E
A
A
Y
N
A
M
-
K
Y
K
G
----
K
I
Y
G
L
P
E
M
V
N
V
R
V
L
F
W
N
K
D
L
F
K
Q
A
G
L
DPN
T
-
P
P
K
T
I
A
E
L
D
Q
M
A
A
K
-
L
T
K
T
--
K
----
N
G
T
I
E
Q
M
--------
G
-----
F
IPWIGQ
G
V
P
----
H
V
M
A
-
G
---
V
F
------
G
-
T
S
L
V
D
S
N
G
N
-
P
I
L
-
S
P
D
------
K
N
P
Q
L
L
N
L
L
K
W
E
V
-
S
Y
S
D
K
Y
G-
A
M
N
----
I
N
K
F
I
A
G
-
M
------
S
Q
N
--
S
SQAN
D
-------
P
F
V
L
G
K
V
A
M
M
I
S
G
E
W
Q
I
N
A
N
K
Q
---
Y
--
N
----
P
----
K
L
-
N
F
G
V
-
G
P
I
P
---
Q
A
P
G
-
G
-
K
-
P
M--
P
-
S
L
M
D
G
N
T
W
--
M
I
P
K
G
S
K
H
P
Q
E
A
M
D
F
I
K
--
W
T
M
D
P
Q
R
I
A
D
T
A
D
K
V
Y
N
I
A
P
I
V
E
---
A
----
A
K
I
Q
-
K
L
N
N
D
P
Y
F
K
E
V
L
N
V
A
Q
K
G
S
I
Y
Y
T
P
A
---------------------------------------------------------
10
PsiBlast_PDB
78.99
27%
-35
- C1 -
3JZJ
2
?
A:
[27-407]
-----------------------------------
V
T
F
--
W
D
T
S
N
E
---
A
-
E
-
K
A
T
Y
Q
A
L
A
E
G
F
E
K
-
E
H
P
K
V
D
V
--
K
Y
---------
V
N
V
P
FG----
E
A
--
N
---
A
K
F
K
N
A
A
G
G
N
S
---
G
-
A
-
P
D
V
M
R
-
T
-
E
V
A
W
-
V
A
D
F
A
S
I
G
Y
-
L
A
P
L
D
G
T
P
A
L
D
D
---
G
S
D
H
L
P
Q
A
A
A
S
T
-
R
Y
E
G
----
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
---
E
-
V
P
G
S
V
A
E
L
K
T
A
A
A
E
-
I
T
E
----------
K
T
G
A
T
--------
G
-----
L
------
Y
L
R
GD--
D
P
---
Y
---
W
F
------
L
-
P
Y
L
Y
G
E
G
G
D
-
L
V
D
-
E
K
N
------
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
----
R
V
--
I
K
D
----
L
V
D
S
K
A
A
-
I
------
T
D
A
--
S
----
D
G
W
N
N
M
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
G
P
W
A
I
-
E
D
V
K
A
GA
R
--
F
----
K
----
D
A
G
N
L
G
V
-
A
P
V
P
---
A
G
S
A
-
G
---
Q
---
G
-
S
P
Q
G
G
W
N
L
--
S
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
A
K
V
Q
Q
Q
T
T
E
-
K
L
S
-
L
L
P
T
R
T
--
S
V
----
Y
E
V
P
-
S
V
A
D
N
E
M
V
K
F
F
K
P
A
V
D
K
A
V
E
R
P
W
I
A
E
G
N
A
L
F
E
P
I
R
L
--
Q
--------
M
A
N
V
L
S
G
--
E
T
-
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
K
D
----
27
HHSearch
78.57
25%
-49
- C1 -
2GH9
1
?
A:
[2-379]
----------------------------------
K
I
T
V
--
W
T
H
F
G
G
---
P
-
E
-
L
E
W
L
K
E
Q
A
R
T
F
E
R
-
T
-
S
G
T
K
V
--
E
V
---------
V
E
--------
V
P
FA
E
---
I
K
Q
K
F
I
L
G
A
P
Q
---
G
-
Q
A
A
D
L
V
V
-
T
V
P
H
D
W
-
V
G
E
M
A
Q
A
G
V
-
L
E
P
V
G
K
Y
V
T
Q
---
A
Y
L
A
D
L
Q
G
V
A
V
E
A
F
-
T
F
G
G
----
R
L
M
G
L
P
A
F
A
E
S
V
A
L
I
Y
N
K
K
Y
V
K
E
--------
P
P
R
T
W
E
E
F
L
A
L
A
Q
K
-
L
T
T
G
-------
A
T
F
------------
G
-----
F
------
L
Y
N
----
I
G
D--
P
Y--
F
N
------
F
-
G
F
F
K
A
F
G
A
E
N
V
F
A
-
K
D
A
K
G
N
L
D
P
T
K
L
L
I
G
G
E
V
G
E
K
A
L
Q
F
I
K
D
L
--
R
F
K
----
Y
N
L
V
P
E
G
-
V
D
Y
----
G
V
A
--
D
----
G
-------
A
F
K
D
G
A
L
A
M
I
L
N
G
P
W
A
L
-
G
D
Y
K
---
K
-------
A
----
K
V
-
D
F
G
I
-
A
P
F
P
---
V
P
P
G
-
A
K
N
P
W
---
G
-
P
F
L
G
V
Q
G
V
--
V
V
N
A
Y
S
K
N
K
T
Q
A
V
N
F
A
K
T
-
L
V
T
-
G
R
N
L
V
A
F
N
-
Q
A
G
G
R
I
P
V
S
K
--
S
A
----
V
K
Q
--
L
-
E
K
D
P
V
V
A
G
F
S
K
V
F
P
L
G
A
P
M
P
N
I
P
-
E
M
G
K
V
W
-
G
P
W
G
N
A
--------
I
S
L
A
I
Q
R
--
P
D
S
N
V
K
K
I
V
E
D
M
V
A
E
I
K
K
A
I
G
-----
3
PsiBlast_PDB
78.43
28%
-49
- C1 -
2GH9
1
?
A:
[2-338]
----------------------------------
K
I
T
V
--
W
T
H
F
G
G
---
P
-
E
-
L
E
W
L
K
E
Q
A
R
T
F
E
R
T
S
G
T
K
V
E
V
--
V
E
---------
V
P
--------
F
A
--
E
---
I
K
Q
K
F
I
L
G
A
P
Q
---
G
-
Q
A
A
D
L
V
V
-
T
-
V
P
H
D
W
V
G
E
M
A
Q
A
G
V
-
L
E
P
V
G
K
Y
V
T
Q
A
Y
-
L
A
--
D
L
Q
G
V
A
V
E
A
F
-
T
F
G
G
----
R
L
M
G
L
P
A
F
A
E
S
V
A
L
I
Y
N
K
K
Y
V
K
E
--------
P
P
R
T
W
E
E
F
L
A
L
A
Q
K
L
T
T
G
A
--
T
----
F
G
F
L
Y
N
I
--------
G
-----
D
------
P
Y
F
----
N
F
---
G
---
F
F
K
A
F
GAE
N
-
V
F
A
K
D
A
K
G
N
-
L
----
D
P
------
T
K
L
L
I
G
G
E
V
G
E
K
A
L
Q
F
I
K
D
L
--
R
F
K
----
Y
N
L
V
P
E
G
-
V
------
D
Y
G
V
A
D
----
G
-------
A
F
K
D
G
A
L
A
M
I
L
N
G
P
W
A
L
-
G
D
Y
K
---
K
--
A
----
K
-----
V
-
D
F
G
I
-
A
P
F
P
---
V
P
P
G
-
A
-
K
-
N
P
W
-
G
-
P
F
L
G
V
Q
G
V
--
V
V
N
A
Y
S
K
N
K
T
Q
A
V
N
F
A
K
T
-
L
V
T
G
-
R
N
L
V
A
F
N
-
Q
A
G
G
R
I
P
V
S
K
--
S
A
----
V
K
Q
---
L
E
K
D
P
V
V
A
G
F
S
K
V
F
P
L
G
A
P
M
P
N
I
----------------------------------------------------------
22
HHSearch
78.30
25%
-39
- C1 -
3K01
1
?
A:
[24-411]
-----------------------------
V
E
L
S
G
T
V
T
F
--
W
D
T
S
N
E
---
A
-
E
-
K
A
T
Y
Q
A
L
A
E
G
F
E
K
-
E
H
P
K
V
D
V
--
K
Y
---------
V
N
--------
V
P
FG
E
---
A
N
A
K
F
K
N
A
A
G
G
---
N
S
G
A
P
D
V
M
R
-
T
-
E
V
A
W
-
V
A
D
F
A
S
I
G
Y
-
L
A
P
L
D
G
T
P
A
L
---
D
D
G
S
D
H
L
P
Q
A
A
A
S
T
-
R
Y
E
G
----
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
---
E
-
V
P
G
S
V
A
E
L
K
T
A
A
A
E
-
I
T
E
K
--
T
----
G
A
T
------------
G
-----
L
------
Y
L
R
----
G
D
D--
P
Y--
W
F
------
L
-
P
Y
L
Y
G
E
G
G
D
-
L
V
D
-
E
K
N
------
K
T
V
T
V
D
D
E
A
G
V
R
A
Y
R
V
I
K
D
L
--
V
D
S
----
K
A
A
I
T
D
A
-
S
D
G
W
---
N
N
M
--
Q
----
N
-------
A
F
K
S
G
K
V
A
M
M
V
N
G
P
W
A
I
-
E
D
V
K
---
A
--
G
ARFK
D
----
A
G
-
N
L
G
V
-
A
P
V
P
---
A
G
S
A
-
G
-
Q
-----
G
-
S
P
Q
G
G
W
N
L
--
S
V
Y
A
G
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
-
A
K
V
Q
Q
Q
T
T
-
E
K
L
S
L
L
P
T
R
T
--
S
V
----
Y
E
V
P
-
S
V
A
D
N
E
M
V
K
F
F
K
P
A
V
D
K
A
V
E
R
P
W
I
A
-
E
G
N
A
L
F
-
E
P
I
R
L
Q
--------
M
A
N
V
L
S
G
--
E
T
-
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
K
D
Y
---
36
HHSearch
77.01
23%
-44
- C1 -
2GHA
1
?
A:
[3-374]
---------------------------------
P
K
L
T
I
--
W
C
S
E
-----
K
-
Q
-
V
D
I
L
Q
K
L
G
E
E
F
K
A
-
K
Y
-
G
V
E
V
--
E
V
---------
Q
Y
--------
V
N
FQ
D
---
I
K
S
K
F
L
T
A
A
P
E
---
G
-
Q
G
A
D
I
I
V
-
G
-
A
H
D
W
-
V
G
E
L
A
V
N
G
L
-
I
E
P
I
P
N
F
S
D
------
L
K
N
F
Y
E
T
A
L
N
A
F
-
S
Y
G
G
----
K
L
Y
G
I
P
Y
A
M
E
A
I
A
L
I
Y
N
K
D
Y
V
P
E
--------
P
P
K
T
M
D
E
L
I
E
I
A
K
Q
-
I
D
E
E
F
-
G
G---
E
V
R
------------
G
-----
F
------
I
T
S
----
A
A
---
E
FY-
Y
I
------
A
-
P
F
I
F
G
Y
G
G
Y
-
V
F
K
-
Q
T
E
KGLDV-
N
D
I
G
L
A
N
E
G
A
I
K
G
V
K
L
L
K
R
L
--
V
D
E
----
G
I
L
D
P
S
D
-
N
Y
-----
Q
I
M
--
D
----
S
-------
M
F
R
E
G
Q
A
A
M
I
I
N
G
P
W
A
I
-
K
A
Y
K
---
D
-------
A
----
G
I
-
D
Y
G
V
-
A
P
I
P
---
D
L
E
P
-
G
V
P
-
A
---
R
-
P
F
V
G
V
Q
G
F
--
M
V
N
A
K
S
P
N
K
L
L
A
I
E
F
L
T
S
F
I
A
K
-
K
E
T
M
Y
R
I
Y
-
L
G
D
P
R
L
P
S
R
K
--
D
V
----
L
E
L
--
V
-
K
D
N
P
D
V
V
G
F
T
L
S
A
A
N
G
I
P
M
P
N
V
P
-
Q
M
A
A
V
W
-
A
A
M
N
D
A
--------
L
N
L
V
V
N
G
--
K
A
-
T
V
E
E
A
L
K
N
A
V
E
R
I
K
A
Q
I
Q
-----
6
PsiBlast_PDB
76.45
25%
-39
- C1 -
4QSD
2
?
A:
[31-401]
-------------------------------------------
W
S
L
---
D
-
R
D
I
Q
P
A
P
N
L
I
K
E
F
N
A
-
L
N
N
G
I
K
I
--
E
Y
R
Q
-------
L
Q
--------
F
D
--
D
---
V
V
S
E
S
M
R
A
Y
S
T
---
G
-
N
A
P
D
I
I
A
-
I
-
D
N
P
N
-
H
A
M
F
A
S
R
G
A
F
L
D
V
T
D
M
I
A
K
S
D
V
-
I
K
T
E
N
Y
F
P
G
P
L
K
S
V
-
T
W
D
G
----
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
DAA
K
-
P
P
Q
T
W
D
E
L
V
D
A
A
R
K
-
L
T
N
P
--
A
----
K
N
V
Y
-----------
G
-----
I
------
S
F
S
AKAN
E
E
---
G
---
T
F
------
Q
--
F
L
P
W
A
Q
M
A
-
G
A
T
-
Y
K
N
----------
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
--
L
D
E
KLAS
P
D
T
L
T
R
S
-
Q
------
W
D
S
--
T
----
A
-------
T
F
N
A
G
N
A
A
M
A
I
S
G
P
W
E
I
-
D
R
M
L
---
K
--
D
----
A
----
K
F
-
D
W
G
V
T
L
L
P
V
---
P
T
P
D
-
A
-
P
-
R
---
S
-
S
A
M
G
D
Y
N
W
--
A
I
F
S
K
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
K
D
K
---
D
M
F
-
K
N
F
G
Q
L
P
A
R
S
DI
P
V
----
P
P
T
G
-
N
A
L
K
D
E
A
L
K
T
F
V
E
Q
L
K
Y
A
Q
P
R
G
P
S
P
-
E
W
P
K
I
S
K
-
A
I
Q
D
A
--------
I
Q
G
A
L
S
G
--
Q
M
-
T
P
K
A
A
L
D
Q
A
A
E
K
-----------
4
PsiBlast_PDB
75.82
25%
-38
- C1 -
4QRZ
1
?
A:
[31-401]
-------------------------------------------
W
S
L
---
D
-
R
D
I
Q
P
A
P
N
L
I
K
E
F
N
A
-
L
N
N
G
I
K
I
--
E
Y
R
Q
-------
L
Q
--------
F
D
--
D
---
V
V
S
E
S
M
R
A
Y
S
T
---
G
-
N
A
P
D
I
I
A
-
I
-
D
N
P
N
-
H
A
M
F
A
S
R
G
A
F
L
D
V
T
D
M
I
A
K
S
D
V
-
I
K
T
E
N
Y
F
P
G
P
L
K
S
V
-
T
W
D
G
----
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
DAA
K
-
P
P
Q
T
W
D
E
L
V
D
A
A
R
K
-
L
T
N
P
--
A
----
K
N
V
Y
-----------
G
-----
I
------
S
F
S
AKAN
E
E
---
G
---
T
F
------
Q
--
F
L
P
W
A
Q
M
A
-
G
A
T
-
Y
K
N
----------
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
--
L
D
E
KLAS
P
D
T
L
T
R
S
-
Q
------
W
D
S
--
T
----
A
-------
T
F
N
A
G
N
A
A
M
A
I
S
G
P
W
E
I
-
D
R
M
L
---
K
--
D
----
A
----
K
F
-
D
W
G
V
T
L
L
P
V
---
P
T
P
D
-
A
-
P
-
R
---
S
-
S
A
M
G
D
Y
N
W
--
A
I
F
S
K
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
K
D
K
---
D
M
F
-
K
N
F
G
Q
L
P
A
R
S
DI
P
V
----
P
P
T
G
-
N
A
L
K
D
E
A
L
K
T
F
V
E
Q
L
K
Y
A
Q
P
R
G
P
S
P
-
E
W
P
K
I
S
K
-
A
I
Q
D
A
--------
I
Q
G
A
L
S
G
--
Q
M
-
T
P
K
A
A
L
D
Q
A
A
E
K
-----------
5
PsiBlast_PDB
75.75
25%
-37
- C1 -
4QSC
1
?
A:
[31-401]
-------------------------------------------
W
S
L
---
D
-
R
D
I
Q
P
A
P
N
L
I
K
E
F
N
A
-
L
N
N
G
I
K
I
--
E
Y
R
Q
-------
L
Q
--------
F
D
--
D
---
V
V
S
E
S
M
R
A
Y
S
T
---
G
-
N
A
P
D
I
I
A
-
I
-
D
N
P
N
-
H
A
M
F
A
S
R
G
A
F
L
D
V
T
D
M
I
A
K
S
D
V
-
I
K
T
E
N
Y
F
P
G
P
L
K
S
V
-
T
W
D
G
----
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
DAA
K
-
P
P
Q
T
W
D
E
L
V
D
A
A
R
K
-
L
T
N
P
--
A
----
K
N
V
Y
-----------
G
-----
I
------
S
F
S
AKAN
E
E
---
G
---
T
F
------
Q
--
F
L
P
W
A
Q
M
A
-
G
A
T
-
Y
K
N
----------
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
--
L
D
E
KLAS
P
D
T
L
T
R
S
-
Q
------
W
D
S
--
T
----
A
-------
T
F
N
A
G
N
A
A
M
A
I
S
G
P
W
E
I
-
D
R
M
L
---
K
--
D
----
A
----
K
F
-
D
W
G
V
T
L
L
P
V
---
P
T
P
D
-
A
-
P
-
R
---
S
-
S
A
M
G
D
Y
N
W
--
A
I
F
S
K
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
K
D
K
---
D
M
F
-
K
N
F
G
Q
L
P
A
R
S
DI
P
V
----
P
P
T
G
-
N
A
L
K
D
E
A
L
K
T
F
V
E
Q
L
K
Y
A
Q
P
R
G
P
S
P
-
E
W
P
K
I
S
K
-
A
I
Q
D
A
--------
I
Q
G
A
L
S
G
--
Q
M
-
T
P
K
A
A
L
D
Q
A
A
E
K
-----------
30
HHSearch
75.72
21%
-43
- C1 -
1ELJ
4
MALE_PYRFU
A:
[4-380]
-------------------------------
E
E
G
K
V
V
I
--
W
H
A
M
Q
P
---
N
-
E
-
L
E
V
F
Q
S
L
A
E
E
Y
M
A
-
L
C
P
E
V
E
I
--
V
F
---------
E
Q
--------
K
P
--
N
---
L
E
D
A
L
K
A
A
I
P
T
---
G
-
Q
G
P
D
L
F
I
-
W
-
A
H
D
W
-
I
G
K
F
A
E
A
G
L
-
L
E
P
I
D
E
Y
V
T
E
---
D
L
L
N
E
F
A
P
M
A
Q
D
A
M
-
Q
Y
K
G
----
H
Y
Y
A
L
P
F
A
A
E
T
V
A
I
I
Y
N
K
E
M
V
S
E
--------
P
P
K
T
F
D
E
M
K
A
I
M
E
K
-
Y
Y
D
P
A-
N
----
E
K
Y
------------
G
-----
I
------
A
W
P
----
I
N
---
A
Y--
F
I
------
S
-
A
I
A
Q
A
F
G
G
Y
-
Y
F
D
-
D
K
T
------
E
Q
P
G
L
D
K
P
E
T
I
E
G
F
K
F
F
F
T
E
--
I
W
P
----
Y
-
M
A
P
T
G
D
Y
------
N
T
Q
--
Q
----
S
-------
I
F
L
E
G
R
A
P
M
M
V
N
G
P
W
S
I
-
N
D
V
K
---
K
-------
A
----
G
I
-
N
F
G
V
-
V
P
L
P
---
P
I
I
K
D
G
-
K
-
E
Y
W
P
R
-
P
Y
G
G
V
K
L
I
--
Y
F
A
A
G
I
K
N
K
D
A
A
W
K
F
A
K
W
-
L
T
T
S
E
E
S
I
K
T
L
A
-
L
E
L
G
Y
I
P
V
L
T
--
K
V
----
L
D
D
P
-
E
I
K
N
D
P
V
I
Y
G
F
G
Q
A
V
Q
H
A
Y
L
M
P
K
S
P
-
K
M
S
A
V
W
-
G
G
V
D
G
A
--------
I
N
E
I
L
Q
D
PQ
N
A
-
D
I
E
G
I
L
K
K
Y
Q
Q
E
I
L
N
N
M
Q
-----
7
PsiBlast_PDB
75.69
25%
-37
- C1 -
4QSE
2
?
A:
[31-401]
-------------------------------------------
W
S
L
---
D
-
R
D
I
Q
P
A
P
N
L
I
K
E
F
N
A
-
L
N
N
G
I
K
I
--
E
Y
R
Q
-------
L
Q
--------
F
D
--
D
---
V
V
S
E
S
M
R
A
Y
S
T
---
G
-
N
A
P
D
I
I
A
-
I
-
D
N
P
N
-
H
A
M
F
A
S
R
G
A
F
L
D
V
T
D
M
I
A
K
S
D
V
-
I
K
T
E
N
Y
F
P
G
P
L
K
S
V
-
T
W
D
G
----
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
DAA
K
-
P
P
Q
T
W
D
E
L
V
D
A
A
R
K
-
L
T
N
P
--
A
----
K
N
V
Y
-----------
G
-----
I
------
S
F
S
AKAN
E
E
---
G
---
T
F
------
Q
--
F
L
P
W
A
Q
M
A
-
G
A
T
-
Y
K
N
----------
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
--
L
D
E
KLAS
P
D
T
L
T
R
S
-
Q
------
W
D
S
--
T
----
A
-------
T
F
N
A
G
N
A
A
M
A
I
S
G
P
W
E
I
-
D
R
M
L
---
K
--
D
----
A
----
K
F
-
D
W
G
V
T
L
L
P
V
---
P
T
P
D
-
A
-
P
-
R
---
S
-
S
A
M
G
D
Y
N
W
--
A
I
F
S
K
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
K
D
K
---
D
M
F
-
K
N
F
G
Q
L
P
A
R
S
DI
P
V
----
P
P
T
G
-
N
A
L
K
D
E
A
L
K
T
F
V
E
Q
L
K
Y
A
Q
P
R
G
P
S
P
-
E
W
P
K
I
S
K
-
A
I
Q
D
A
--------
I
Q
G
A
L
S
G
--
Q
M
-
T
P
K
A
A
L
D
Q
A
A
E
K
-----------
25
HHSearch
75.41
24%
-36
- C1 -
2ZYO
1
?
A:
[13-395]
---------------------------
K
S
E
G
K
P
D
K
L
V
V
--
W
E
N
A
D
D
---
G
V
Q
-
L
N
N
T
K
K
W
A
G
E
F
T
K
-
K
-
T
G
I
Q
V
--
E
V
---------
V
P
--------
V
A
LL
K
---
Q
Q
E
K
L
T
L
D
G
P
A
---
G
-
K
G
A
D
L
V
T
-
W
-
P
H
D
R
-
L
G
E
A
V
T
K
G
L
-
L
Q
P
I
Q
V
D
N
S
-----
V
K
N
Q
F
D
D
V
A
M
K
A
L
-
T
Y
G
G
----
K
L
Y
G
L
P
K
A
I
E
S
V
A
L
I
Y
N
K
K
L
M
G
Q
--------
V
P
A
T
Y
D
E
L
F
Q
Y
A
K
A
-
N
N
K
P
D-
E
----
Q
K
Y
------------
G
-----
V
------
L
F
E
----
A
N
---
N
F--
Y
Y
------
T
Y
F
L
F
A
A
K
G
A
A
-
V
F
K
-
E
Q
D
GTLDP-
N
E
I
G
L
N
S
P
E
A
V
Q
G
M
N
E
V
Q
K
W
--
F
T
E
----
A
R
L
P
Q
S
L
K
A
------
D
T
V
--
N
----
G
-------
L
F
K
S
G
K
V
A
A
V
I
N
G
P
W
A
I
-
K
D
Y
Q
---
A
-------
A
----
G
I
-
N
V
G
V
-
A
P
L
P
---
K
I
D
G
-
K
-
D
-
A
---
Q
-
T
F
I
G
V
K
G
W
--
Y
L
S
A
Y
S
K
Y
P
K
Y
A
T
E
L
M
Q
F
-
L
T
S
-
K
E
A
L
A
S
R
F
-
K
E
T
G
E
I
P
P
Q
K
--
E
L
----
L
N
D
P
-
M
I
K
N
N
P
V
V
N
G
F
A
K
Q
A
S
K
G
V
P
M
P
S
I
P
-
E
M
G
V
V
W
-
E
P
I
N
N
A
--------
H
T
F
V
A
Q
G
--
K
Q
-
T
P
E
Q
A
L
N
D
A
V
K
I
M
K
E
K
I
Q
T
M
---