@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0773: (2016-03-18 )
MKSFQALFIEKEADNTSLHFRETTIDNLPENEVTIEVHYSGINYKDGLAVLPDGKIVSEYPFIPGIDASGVVVNSKSDQFQVGDEVIVTSYDFGVSYFGGYSEFIRVPAEWVVPLPDGLSLKEAMILGTAGFTAALSVDALEFSGVTPNAGKIAVSGATGGVGSLSSAILSKRGFSVVASSGKSDAKEFLEKFGVSEIVSREAFQPEKVRALDKQLYAGAIDCVGGKPLSYLLTAVQYGGAVTTCGMSAGGKLDTTVFPFILRGIQLFGIDSVLCPMSKRERIWNRLATDYKLTNLESLATEIAFSELPESLHQVMNGGVTGRYLVKVK
Atome Classification :
(20 SA)
.........10....-------------....20......-..30........40........50..-------------..----.----...60........70....-.--...80........90--.--------------------.------------------------------------------..---------------------....100.......-110.......120.......130-.........140......-.150.......160.......170...-.-...180.......190.......200.----.-------------------.----....210.......220---......-...230......-.-240.......250-.-......260.......270...--.----...----280...---...-.290--........300.---------.......310.......320.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKS
F
Q
A
L
F
I
E
KEADN-------------T
S
L
H
F
R
ETTIDN-LPEN
E
V
T
I
E
V
H
YSGINYKD
G
L
A
VLPD-------------G
K
----
I
----
V
SEYPFIPGIDAS
G
V
V
VNS-K--SD
Q
F
QVG
D
E
V
I
V
T
S
Y
--D--------------------F------------------------------------------G
V
---------------------
S
YFG
G
Y
S
E
F
I
RV
P
A
-
E
W
V
V
PLPDGL
S
L
K
E
A
M
I
LGTA---GF
T
A
A
L
S
V
D
A
L
E
FSGVTP-NA
G
K
I
A
V
SGATGG
V
G
S
L
S
S
A
I
L
SKRG
F
-
S
-
V
V
ASSG
K
S
D
A
K
E
F
L
E
KFG
V
S
E
I
V
S
R
EA----F-------------------
Q
----
P
E
K
V
R
A
L
D
K
Q
L
YA
G
A
-----
I
DCVGG-
K
P
L
S
Y
L
L
T
A
V
QY-G-G
A
V
T
TCGMSAGGK-L-D
T
T
V
F
P
F
I
L
R
G
I
Q
L
FGI
D
S
VLC--P----
M
S
K
----
R
E
R
I
W
N
---
R
LA-TDY---KLT
N
L
E
S
L
A
-
T
E
---------
I
A
F
S
E
L
P
E
S
L
H
Q
V
M
NGGVT
G
R
Y
L
V
KVK
2
PsiBlast_PDB
94.50
50%
-106
- C1 -
1Y9E
2
YHFP_BACSU
A:
[5-330]
---
F
Q
A
L
Q
A
E
K
N
A
D
D
-------------
V
S
V
H
V
K
T
I
S
T
E
D
-
L
P
K
D
G
V
L
I
K
V
A
Y
S
G
I
N
Y
K
D
G
L
A
G
K
A
G
-------------
G
N
----
I
----
V
R
E
Y
P
L
I
L
G
I
D
A
A
G
T
V
V
S
S
-
N
--
D
P
R
F
A
E
G
D
E
V
I
A
T
S
Y
--
E
--------------------
L
------------------------------------------
G
V
---------------------
S
R
D
G
G
L
S
E
Y
A
S
V
P
G
-
D
W
L
V
P
L
P
Q
N
L
S
L
K
E
A
M
V
Y
G
T
A
---
G
F
T
A
A
L
S
V
H
R
L
E
Q
N
G
L
S
P
-
E
K
G
S
V
L
V
T
G
A
T
G
G
V
G
G
I
A
V
S
M
L
N
K
R
G
Y
-
D
-
V
V
A
S
T
G
N
R
E
A
A
D
Y
L
K
Q
L
G
A
S
E
V
I
S
R
E
D
----
V
-------------------
Y
----
D
G
T
L
K
A
L
S
K
Q
Q
W
Q
G
A
-----
V
D
P
V
G
G
-
K
Q
L
A
S
L
L
S
K
I
Q
Y
-
G
-
G
S
V
A
V
S
G
L
T
G
G
G
E
-
V
-
P
A
T
V
Y
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Y
C
--
P
----
M
D
V
----
R
A
A
V
W
E
---
R
M
S
-
S
D
L
---
K
P
D
Q
L
L
T
I
V
D
R
E
---------
V
S
L
E
E
T
P
G
A
L
K
D
I
L
Q
N
R
I
Q
G
R
V
I
V
K
L
-
22
PsiBlast_CBE
93.94
44%
-100
- C1 -
1O8C
2
ACUI_ECOLI
D:
[22-345]
---
L
Q
A
L
L
L
E
Q
Q
D
G
K
-------------
T
L
A
S
V
Q
T
L
D
E
S
R
-
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
-------------
G
K
----
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
-
E
--
D
P
R
F
H
A
G
Q
E
V
L
L
T
G
W
--
G
--------------------
V
------------------------------------------
G
E
---------------------
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
-
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
---
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
V
R
P
-
Q
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
-
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
----
F
-------------------------
A
E
S
R
P
L
E
K
Q
V
W
A
G
A
-----
I
D
T
V
G
D
-
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
-
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
-
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
--
P
----
P
E
R
----
R
A
Q
A
W
Q
---
R
L
V
-
A
D
L
---
P
E
S
F
Y
T
Q
A
A
-
K
E
---------
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
N
24
PsiBlast_CBE
93.88
44%
-103
- C1 -
1O8C
2
ACUI_ECOLI
B:
[22-345]
---
L
Q
A
L
L
L
E
Q
Q
D
G
K
-------------
T
L
A
S
V
Q
T
L
D
E
S
R
-
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
-------------
G
K
----
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
-
E
--
D
P
R
F
H
A
G
Q
E
V
L
L
T
G
W
--
G
--------------------
V
------------------------------------------
G
E
---------------------
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
-
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
---
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
V
R
P
-
Q
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
-
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
----
F
-------------------------
A
E
S
R
P
L
E
K
Q
V
W
A
G
A
-----
I
D
T
V
G
D
-
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
-
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
-
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
--
P
----
P
E
R
----
R
A
Q
A
W
Q
---
R
L
V
-
A
D
L
---
P
E
S
F
Y
T
Q
A
A
-
K
E
---------
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
N
4
PsiBlast_PDB
93.81
44%
-104
- C1 -
1O89
-
ACUI_ECOLI
A:
[1-323]
---
L
Q
A
L
L
L
E
Q
Q
----------------
T
L
A
S
V
Q
T
L
D
E
S
R
-
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
-------------
G
K
----
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
-
E
--
D
P
R
F
H
A
G
Q
E
V
L
L
T
G
W
--
G
--------------------
V
------------------------------------------
G
E
---------------------
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
-
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
---
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
V
R
P
-
Q
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
-
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
----
F
-------------------------
A
E
S
R
P
L
E
K
Q
V
W
A
G
A
-----
I
D
T
V
G
D
-
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
-
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
-
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
--
P
----
P
E
R
----
R
A
Q
A
W
Q
---
R
L
V
-
A
D
L
---
P
E
S
F
Y
T
Q
A
A
-
K
E
---------
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
-
5
PsiBlast_PDB
93.74
44%
-101
- C1 -
1O8C
2
ACUI_ECOLI
A:
[22-345]
---
L
Q
A
L
L
L
E
Q
Q
D
G
K
-------------
T
L
A
S
V
Q
T
L
D
E
S
R
-
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
-------------
G
K
----
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
-
E
--
D
P
R
F
H
A
G
Q
E
V
L
L
T
G
W
--
G
--------------------
V
------------------------------------------
G
E
---------------------
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
-
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
---
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
V
R
P
-
Q
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
-
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
----
F
-------------------------
A
E
S
R
P
L
E
K
Q
V
W
A
G
A
-----
I
D
T
V
G
D
-
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
-
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
-
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
--
P
----
P
E
R
----
R
A
Q
A
W
Q
---
R
L
V
-
A
D
L
---
P
E
S
F
Y
T
Q
A
A
-
K
E
---------
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
N
48
Fugue
92.38
44%
-102
- C1 -
1O89
-
ACUI_ECOLI
A:
[1-323]
---
L
Q
A
L
L
L
E
Q
---
Q
-------------
T
L
A
S
V
Q
T
L
D
E
S
R
-
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
-------------
G
K
----
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
-
E
--
D
P
R
F
H
A
G
Q
E
V
L
L
T
G
W
--
G
--------------------
V
------------------------------------------
G
E
---------------------
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
-
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
---
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
V
R
P
-
Q
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
-
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
----
F
-------------------
A
----
E
S
R
--
P
L
E
K
Q
V
W
A
G
A
-----
I
D
T
V
G
D
-
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
-
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
-
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
--
P
----
P
E
R
----
R
A
Q
A
W
Q
---
R
L
V
-
A
D
L
---
P
E
S
F
Y
T
Q
A
A
-
K
E
---------
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
-
23
PsiBlast_CBE
91.49
44%
-98
- C1 -
1O8C
2
ACUI_ECOLI
C:
[23-345]
----
Q
A
L
L
L
E
Q
Q
D
G
K
-------------
T
L
A
S
V
Q
T
L
D
E
S
R
-
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
-------------
G
K
----
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
-
E
--
D
P
R
F
H
A
G
Q
E
V
L
L
T
G
W
--
G
--------------------
V
------------------------------------------
G
E
---------------------
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
-
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
---
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
V
R
P
-
Q
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
-
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
----
F
-------------------------
A
E
S
R
P
L
E
K
Q
V
W
A
G
A
-----
I
D
T
V
G
D
-
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
-
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
-
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
--
P
----
P
E
R
----
R
A
Q
A
W
Q
---
R
L
V
-
A
D
L
---
P
E
S
F
Y
T
Q
A
A
-
K
E
---------
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
N
6
PsiBlast_PDB
91.08
43%
-99
- C1 -
3NX4
2
?
A:
[2-324]
----
Q
A
L
I
L
E
Q
Q
D
G
K
-------------
T
L
A
S
V
Q
H
L
E
E
S
Q
-
L
P
A
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
-------------
G
K
----
I
----
I
R
H
F
P
M
I
P
G
I
D
F
A
G
T
V
H
A
S
-
E
--
D
P
R
F
H
A
G
Q
E
V
L
L
T
G
W
--
G
--------------------
V
------------------------------------------
G
E
---------------------
N
H
W
G
G
L
A
E
R
A
R
V
K
G
-
D
W
L
V
A
L
P
A
G
L
S
S
R
N
A
M
I
I
G
T
A
---
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
I
R
P
-
Q
D
G
E
V
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
-
Q
-
V
A
A
V
S
G
R
E
S
T
H
G
Y
L
K
S
L
G
A
N
R
I
L
S
R
D
E
----
F
-------------------------
A
E
S
R
P
L
E
K
Q
L
W
A
G
A
-----
I
D
T
V
G
D
-
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
-
G
C
V
A
A
C
G
L
A
G
G
F
A
-
L
-
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
--
P
----
P
A
R
----
R
A
E
A
W
A
---
R
L
V
-
K
D
L
---
P
E
S
F
Y
A
Q
A
A
-
T
E
---------
I
T
L
A
D
A
P
K
F
A
D
A
I
I
N
N
Q
V
Q
G
R
T
L
V
K
I
K
21
PsiBlast_CBE
89.73
47%
-98
- C1 -
4JXK
2
?
B:
[25-349]
--
E
F
T
A
-
W
I
A
R
E
N
E
G
-------------
A
I
G
L
S
Q
E
T
V
G
E
S
F
L
P
Q
G
E
V
T
I
Q
V
E
Y
S
S
V
N
F
K
D
A
L
A
L
T
P
K
-------------
G
G
----
V
----
V
R
E
Y
P
I
V
P
G
I
D
V
A
G
T
V
V
E
S
-
Q
--
S
P
E
F
S
V
G
D
T
V
V
A
H
G
Y
--
D
--------------------
I
------------------------------------------
G
T
---------------------
A
R
H
G
G
Y
A
Q
F
A
R
V
P
A
-
D
W
V
V
K
L
-
D
G
M
S
T
R
T
A
A
A
I
G
T
A
---
G
F
T
A
A
M
S
V
E
A
L
Q
S
R
G
V
E
P
-
G
N
G
P
V
L
V
T
G
A
S
G
G
V
G
T
V
A
V
D
L
L
S
A
A
G
F
-
E
-
V
V
A
S
S
G
K
P
E
K
A
E
L
L
T
Q
L
G
A
S
K
V
I
G
R
L
P
----
E
-------------------
P
----
D
T
K
P
R
P
L
G
K
A
Q
W
A
A
A
-----
V
D
C
V
G
G
-
A
T
L
A
H
V
L
S
T
I
E
Y
-
G
-
G
A
V
A
A
S
G
L
T
G
G
P
K
-
L
-
E
T
T
V
L
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Q
Y
--
P
----
I
D
Q
----
R
R
R
L
W
G
---
R
L
A
-
S
D
L
---
A
P
S
R
L
E
S
I
T
-
H
D
---------
V
P
I
A
D
V
V
S
V
I
D
Q
V
R
A
G
T
Y
S
G
R
A
V
V
A
V
-
28
HHSearch
88.99
44%
-98
- C1 -
3NX4
2
?
A:
[1-324]
---
M
Q
A
L
I
L
E
Q
Q
D
G
K
-------------
T
L
A
S
V
Q
H
L
E
E
S
Q
-
L
P
A
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
-------------
G
K
----
I
----
I
R
H
F
P
M
I
P
G
I
D
F
A
G
T
V
H
A
S
-
E
--
D
P
R
F
H
A
G
Q
E
V
L
L
T
G
W
--
G
--------------------
V
------------------------------------------
G
E
---------------------
N
H
W
G
G
L
A
E
R
A
R
V
K
G
-
D
W
L
V
A
L
P
A
G
L
S
S
R
N
A
M
I
I
G
T
A
---
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
I
R
P
Q
D
-
G
E
V
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
-
Q
-
V
A
A
V
S
G
R
E
S
T
H
G
Y
L
K
S
L
G
A
N
R
I
L
S
R
D
E
----
F
-------------------
A
----
E
S
--
R
P
L
E
K
Q
L
W
A
G
A
-----
I
D
T
V
G
D
-
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
-
G
C
V
A
A
C
G
L
A
G
G
F
A
-
L
-
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
--
P
P
A
R
R
A
E
A
----
W
A
R
L
V
K
---
D
L
P
E
S
F
Y
------
A
Q
--
A
A
-
T
E
---------
I
T
L
A
D
A
P
K
F
A
D
A
I
I
N
N
Q
V
Q
G
R
T
L
V
K
I
K
3
PsiBlast_PDB
88.38
47%
-93
- C1 -
4JXK
2
?
A:
[25-349]
--
E
F
T
A
-
W
I
A
R
E
N
E
G
-------------
A
I
G
L
S
Q
E
T
V
G
E
S
F
L
P
Q
G
E
V
T
I
Q
V
E
Y
S
S
V
N
F
K
D
A
L
A
L
T
P
K
-------------
G
G
----
V
----
V
R
E
Y
P
I
V
P
G
I
D
V
A
G
T
V
V
E
S
-
Q
--
S
P
E
F
S
V
G
D
T
V
V
A
H
G
Y
--
D
--------------------
I
------------------------------------------
G
T
---------------------
A
R
H
G
G
Y
A
Q
F
A
R
V
P
A
-
D
W
V
V
K
L
-
D
G
M
S
T
R
T
A
A
A
I
G
T
A
---
G
F
T
A
A
M
S
V
E
A
L
Q
S
R
G
V
E
P
-
G
N
G
P
V
L
V
T
G
A
S
G
G
V
G
T
V
A
V
D
L
L
S
A
A
G
F
-
E
-
V
V
A
S
S
G
K
P
E
K
A
E
L
L
T
Q
L
G
A
S
K
V
I
G
R
L
P
----
E
-------------------
P
----
D
T
K
P
R
P
L
G
K
A
Q
W
A
A
A
-----
V
D
C
V
G
G
-
A
T
L
A
H
V
L
S
T
I
E
Y
-
G
-
G
A
V
A
A
S
G
L
T
G
G
P
K
-
L
-
E
T
T
V
L
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Q
Y
--
P
----
I
D
Q
----
R
R
R
L
W
G
---
R
L
A
-
S
D
L
---
A
P
S
R
L
E
S
I
T
-
H
D
---------
V
P
I
A
D
V
V
S
V
I
D
Q
V
R
A
G
T
Y
S
G
R
A
V
V
A
V
-
40
HHSearch
63.24
20%
-91
- C1 -
3TQH
3
?
A:
[5-321]
-
K
E
M
K
A
I
Q
F
D
Q
F
G
P
P
-------------
K
V
L
K
L
V
D
T
P
T
P
E
-
Y
R
K
N
Q
M
L
I
K
V
H
A
A
S
L
N
P
I
D
Y
K
T
R
N
G
S
-------------
G
F
----
V
A
K
K
L
K
N
N
L
P
S
G
L
G
Y
D
F
S
G
E
V
I
E
L
-
G
SD
V
N
N
V
N
I
G
D
K
V
M
G
I
A
G
------------------------------------------------------------------
F
P
---------------------
D
H
P
C
C
Y
A
E
Y
V
C
A
S
P
-
D
T
I
I
Q
K
L
E
K
L
S
F
L
Q
A
A
S
L
P
T
A
---
G
L
T
A
L
Q
A
L
N
Q
A
---
E
V
K
Q
-
G
-
D
V
V
L
I
H
A
G
A
G
G
V
G
H
L
A
I
Q
L
A
K
Q
K
G
T
-
T
-
V
I
T
T
A
S
K
-
R
N
H
A
F
L
K
A
L
G
A
E
Q
C
I
N
Y
H
E
----
E
-------------------
D
------
F
L
L
-
A
I
S
T
P
V
D
A
V
-----
I
D
L
V
G
G
-
D
V
G
I
Q
S
I
D
C
L
K
E
-
T
-
G
C
I
V
S
V
P
T
I
T
A
G
R
-
V
--
I
E
V
A
--
K
Q
K
H
R
R
A
F
G
L
L
-
K
Q
F
--
N
----
I
E
E
----
L
H
Y
L
G
K
---
L
V
S
E
D
K
L
---
R
I
--
E
--
I
S
-
R
I
---------
F
Q
L
S
E
A
V
T
A
H
E
L
L
E
T
G
H
V
R
G
K
L
V
F
K
V
R
32
HHSearch
60.15
21%
-80
* C1 *
2EIH
1
?
A:
[1-342]
---
M
R
A
V
V
M
R
A
R
G
G
P
-------------
E
V
L
E
V
A
D
L
P
V
P
E
-
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
V
-------------
A
S
----
P
----
K
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
-
G
PG
V
E
G
F
A
P
G
D
E
V
V
I
N
P
G
--
L
S-------------------
C
GRC
E
R
C
L
A
GEDNLCPRYQIL----------------------
G
E
---------------------
H
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
A
A
I
P
L
T
---
F
L
T
A
W
Q
M
V
V
D
K
L
G
--
V
R
P
-
G
-
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
-
R
-
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
T
H
PD--
W
-------------------
P
----
K
E
V
R
R
L
T
G
G
K
G
A
D
K
V
-----
V
D
H
T
G
A
-
L
Y
F
E
G
V
I
K
A
T
A
N
-
G
-
G
R
I
A
I
A
G
A
S
S
G
Y
E
-
G
-
T
L
P
F
A
H
V
F
Y
R
Q
L
S
I
L
G
S
T
M
--
A
--
S
----
K
S
R
----
L
F
P
I
L
R
---
F
V
E
E
G
K
L
---
K
P
--
V
--
V
G
-
Q
V
---------
L
P
L
E
A
A
A
E
G
H
R
L
L
E
E
R
R
V
F
G
K
V
V
L
Q
V
-
35
HHSearch
58.13
21%
-84
- C1 -
3S2E
7
?
A:
[1-339]
-
A
M
M
K
A
A
V
V
R
A
F
G
A
P
---------------
L
T
I
D
E
V
P
V
P
Q
-
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
G
D
-------------
W
P
----
V
----
K
P
T
L
P
F
I
P
G
H
E
G
V
G
Y
V
S
A
V
-
G
SG
V
S
R
V
K
E
G
D
R
V
G
V
P
W
L
YS
A
CGYC
E
H
C
L
Q
GWETLCEK
Q
Q
N
T
------------------------------------------
G
Y
---------------------
S
V
N
G
G
Y
G
E
Y
V
V
A
D
P
-
N
Y
V
G
L
L
P
D
K
V
G
F
V
E
I
A
P
I
L
C
A
---
G
V
T
V
Y
K
G
L
K
V
T
---
D
T
R
P
-
G
-
Q
W
V
V
I
S
G
I
-
G
G
L
G
H
V
A
V
Q
Y
A
R
A
M
G
L
-
R
-
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
R
D
TD--
P
-------------------
A
----
A
W
L
Q
K
E
I
G
-
G
A
H
G
V
L
-----
V
T
A
V
S
P
-
K
A
F
S
Q
A
I
G
M
V
R
R
-
G
-
G
T
I
A
L
N
G
L
P
P
G
D
--
F
-
G
T
P
I
F
D
V
V
L
K
G
I
T
I
R
G
S
I
V
--
G
--
T
----
R
S
D
----
L
Q
E
S
L
D
---
F
A
A
H
G
D
V
---
K
A
-----
T
V
-
S
T
---------
A
K
L
D
D
V
N
D
V
F
G
R
L
R
E
G
K
V
E
G
R
V
V
L
D
F
S
45
HHSearch
57.39
18%
-88
- C1 -
2FZW
6
ADHX_HUMAN
A:
[4-371]
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
---------------
L
S
I
E
E
I
E
V
A
P
-
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
T
L
S
G
A
-------------
D
P
---------
E
G
C
F
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
-
G
EG
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
--
P
Q-------------------
C
GECKFCLNPKTNLCQKI
R
V
T
Q
G
K
GLMPDGTSRFTCKG
K
T
I
L
-
H
Y
---------------------
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
-
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
---
I
S
T
G
Y
G
A
A
V
N
T
A
K
--
L
E
P
-
G
-
S
V
C
A
V
F
G
L
-
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
-
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
----
F
-------------------
S
KP
I
Q
E
V
L
I
E
M
T
-
D
G
G
V
D
Y
S
-----
F
E
C
I
G
N
V
K
V
M
R
A
A
L
E
A
C
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
-
E
I
A
T
R
P
F
Q
-
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
--
K
S---
V
E
S
----
V
P
K
L
V
S
---
E
Y
M
S
K
K
I
---
K
V
D
E
F
--
V
T
-
H
N
---------
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
-
R
T
V
V
---
29
HHSearch
57.17
19%
-82
- C1 -
3KRT
1
?
A:
[28-421]
P
E
S
Y
R
A
I
T
V
H
K
D
E
T
E
MFAGLETRDKDPR
K
S
I
H
L
D
D
V
P
V
P
E
-
L
G
P
G
E
A
L
V
A
V
M
A
S
S
V
N
Y
N
S
V
H
T
S
I
F
E
PLST
F
G
F
L
E
R
Y
G
R
V
S
DLAK
R
----
H
D
L
P
Y
H
V
I
G
S
D
L
A
G
V
V
L
R
T
-
G
PG
V
N
A
W
Q
A
G
D
E
V
V
A
H
C
L
--
S
--------------------
V
------------------------------------------
E
L
ESSDGHNDTMLDPEQRIWGFE
T
N
F
G
G
L
A
E
I
A
L
V
K
S
-
N
Q
L
M
P
K
P
D
H
L
S
W
E
E
A
A
A
P
G
L
V
---
N
S
T
A
Y
R
Q
L
V
S
R
N
G
A
G
M
K
Q
-
G
-
D
N
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
T
Q
F
A
L
A
G
G
A
-
N
-
P
I
C
V
V
S
S
P
Q
K
A
E
I
C
R
A
M
G
A
E
A
I
I
D
R
N
A
----
E
GYRFWKDENTQD
P
K
E
W
K
R
F
G
----
K
R
I
R
E
L
T
G
G
E
D
I
D
I
V
-----
F
E
H
P
G
R
-
E
T
F
G
A
S
V
F
V
T
R
K
-
G
-
G
T
I
T
T
C
A
S
T
S
G
Y
M
-
H
-
E
Y
D
N
R
Y
L
W
M
S
L
K
R
I
I
G
S
H
F
--
A
--
N
----
Y
R
E
----
A
W
E
A
N
R
---
L
I
A
K
G
R
I
---
H
P
--
T
--
L
S
-
K
V
---------
Y
S
L
E
D
T
G
Q
A
A
Y
D
V
H
R
N
L
H
Q
G
K
V
G
V
L
C
-
47
HHSearch
56.74
19%
-87
- C1 -
3UKO
10
ADHX_ARATH
A:
[6-377]
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
---------------
L
V
I
E
D
V
Q
V
A
P
-
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
T
W
S
G
K
-------------
D
P
----
E
-----
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
-
G
EG
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
--
A
E-------------------
C
RECKFCKSGKTNLCGKV
R
S
A
T
G
V
GIMMNDRKSR
F
S
V
NG
K
P
I
Y
H
F
---------------------
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
-
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
---
V
P
T
G
L
G
A
V
W
N
T
A
K
--
V
E
P
-
G
-
S
N
V
A
I
F
G
L
-
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
-
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
HDKP
I
-------------------
Q
----
E
V
I
V
D
L
T
-
D
G
G
V
D
Y
S
-----
F
E
C
I
G
N
V
S
V
M
R
A
A
L
E
C
C
H
K
-
G
W
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
-
S
T
R
P
F
Q
-
L
V
T
G
R
V
W
K
G
T
A
F
G
G
F
K-
S
----
R
T
Q
----
V
P
W
L
V
E
---
K
Y
M
N
K
E
I
---
K
V
D
E
Y
--
I
T
-
H
N
---------
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
-
C
L
R
C
V
L
D
T
S
18
PsiBlast_PDB
56.66
24%
-86
- C1 -
4EYE
12
?
A:
[22-340]
M
K
A
I
Q
A
---
Q
S
L
S
G
P
-------------
E
G
L
V
Y
T
D
V
E
T
P
G
-
A
G
P
N
V
V
V
V
D
V
K
A
A
G
V
C
F
P
D
Y
L
M
T
K
G
E
-------------
Y
Q
----
L
----
K
M
E
P
P
F
V
P
G
I
E
T
A
G
V
V
R
S
A
P
E
--
G
S
G
I
K
P
G
D
R
V
M
A
----------------------------------------------------------------------
F
---------------------
N
F
I
G
G
Y
A
E
R
V
A
V
A
P
-
S
N
I
L
P
T
P
P
Q
L
D
D
A
E
A
V
A
L
I
A
N
---
Y
H
T
M
Y
F
---
A
Y
A
R
R
G
Q
L
R
-
A
G
E
T
V
L
V
L
G
A
A
G
G
I
G
T
A
A
I
Q
I
A
K
G
M
G
A
-
K
-
V
I
A
V
V
N
R
T
A
A
T
E
F
V
K
S
V
G
A
D
I
V
L
P
L
E
E
----
G
-------------------
W
----
A
K
A
V
R
----
E
A
T
G
G
A
GVD
M
V
V
D
P
I
G
---
A
F
D
D
A
V
R
T
L
A
S
-
E
-
G
R
L
L
V
V
------------
K
V
N
R
L
L
L
R
N
A
S
L
I
G
V
----------------------
A
W
G
E
F
L
R
T
H
-
A
D
Y
L
Y
E
T
Q
A
G
L
E
K
L
V
-
A
E
G
M
R
P
P
VS
A
R
I
P
L
S
E
G
R
Q
A
L
Q
D
F
A
D
G
K
V
Y
G
K
M
V
L
---
38
HHSearch
56.57
16%
-79
- C1 -
3QWB
3
QOR_YEAST
A:
[6-333]
P
E
Q
Q
K
V
I
L
I
D
E
I
G
G
Y
-------------
D
V
I
K
Y
E
D
Y
P
V
P
S
-
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
I
-------------
Y
P
----------
C
E
K
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
-
G
KG
V
T
N
F
E
V
G
D
Q
V
A
Y
I
S
--------------------------------------------------------------------------------------------
N
S
T
F
A
Q
Y
S
K
I
S
S
Q
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
K
L
Y
A
A
G
L
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
--
V
K
K
-
G
-
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
-
H
-
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
ED--
I
-------------------
L
----
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
-----
F
D
S
V
G
K
-
D
T
F
E
I
S
L
A
A
L
K
R
-
K
-
G
V
F
V
S
F
G
N
A
S
G
L
I
-
P
-
P
F
S
I
T
R
L
S
P
K
N
I
T
L
V
R
P
Q
L
Y
G
Y
I
A
D
----
P
E
E
W
K
Y
Y
S
D
E
F
F
G
---
L
V
N
S
K
K
L
---
N
I
--
K
--
I
Y
-
K
T
---------
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
K
T
V
G
K
L
V
L
E
I
P
37
HHSearch
54.65
24%
-79
- C1 -
3UOG
2
?
A:
[25-363]
S
K
W
M
Q
E
W
S
T
E
T
V
A
P
--------------
H
D
L
K
L
A
E
R
P
V
P
E
-
A
G
E
H
D
I
I
V
R
T
L
A
V
S
L
N
Y
R
D
K
L
V
L
E
T
G
-------------
M
G
----
L
----
D
L
A
F
P
F
V
P
A
S
D
M
S
G
V
V
E
A
V
-
G
KS
V
T
R
F
R
P
G
D
R
V
I
S
T
F
A
--
P
GWLD
G
L
R
P
G
T
GRTPAYET--
L
------------------------------------------
G
G
---------------------
A
H
P
G
V
L
S
E
Y
V
V
L
P
E
-
G
W
F
V
A
A
P
K
S
L
D
A
A
E
A
S
T
L
P
C
A
---
G
L
T
A
W
F
A
L
V
E
K
G
H
--
L
R
A
-
G
-
D
R
V
V
V
Q
G
T
-
G
G
V
A
L
F
G
L
Q
I
A
K
A
T
G
A
-
E
-
V
I
V
T
S
S
S
R
E
K
L
D
R
A
F
A
L
G
A
D
H
G
I
N
R
L
E
ED--
W
-------------------
V
----
E
R
V
Y
A
L
T
G
D
R
G
A
D
H
I
-----
L
E
I
A
G
G
-
A
G
L
G
Q
S
L
K
A
V
A
P
-
D
-
G
R
I
S
V
I
G
V
L
E
G
F
E
-
V
-
S
G
P
V
G
P
L
L
L
K
S
P
V
V
Q
G
I
S
V
--
G
--
H
----
R
R
A
----
L
E
D
L
V
G
---
A
V
D
R
L
G
L
---
K
--
P
V
--
I
D
-
M
R
---------
Y
K
F
T
E
V
P
E
A
L
A
H
L
D
R
G
-
P
F
G
K
V
V
I
E
F
-