@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0807: (2016-03-18 )
VTETIIRFENVTKQFDNDPPVLDNVSFEIEKGKFYTLLGPSGCGKTTILRLIAGFLEASKGQIYLGDKVINQIPANKRPVNTVFQDYALFPHLNVYENVAFGLRIKKLKKEAIDEKVKEALRFVNLKGYEKREISEMSGGQRQRVAIARAIVNEPEVILLDEPLSALDLKLRTEMQYELRDLQKRLGITFIFVTHDQEEALAMSDEIFVLNKGEIQQSGTPIDIYDEPINKFVADFIGESNIVNGKMIQDFEVEFVERRFECVDQGFRPNEVVEVVIRPEDLEITSAEKGQLQVTVDWMLFRGVHYEVGCIDIDGNEWLVHTTRKVRVGDKIGLAFEPEAIHVMRLGETEEEFDKRLDSYDEVQ
Atome Classification :
(43 SA)
.........10......-..20---.---........30........40........50........60...--------.-------.-------...70---.-----.------....------...80....--....90........100-.......110.......120....-...130----.......140.......150.......160.......170.......180....---...190.......200.......210.......220.......230.......240.........250-----.--..-----...--.----..260.--.-----.----.---.----..270----.....--..280...---..------.------..------.290.......300.----......310...-.-...320.--.--.--..--....330.......340.......350.......360..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VT
E
T
I
I
R
F
E
N
V
T
K
QFDN-DPP----V---LDN
V
S
F
E
I
EK
G
K
F
Y
T
L
LGPSGC
G
K
T
T
I
L
R
L
I
A
G
F
L
EASKG
Q
I
Y
--------L-------
G
-------
D
K
V
I
----
N
-----Q------IPAN------KR
P
V
N
T
V
F
Q
--
D
YALFPH
L
N
V
Y
E
N
V
A
F
G
-
L
R
I
K
K
L
K
K
E
A
I
D
E
K
V
K
E
A
L
R
F
VNL-KGY
E
K
R
----
E
I
S
E
MSGGQ
R
Q
R
V
A
I
A
R
A
IVNEP
E
V
I
L
LDEPL
S
A
L
D
L
K
L
R
T
E
M
Q
Y
E
L
R
D
L
Q
K
RL---
G
I
T
F
I
F
V
THDQ
E
E
A
LAMS
D
E
I
F
V
L
NK
G
E
IQQSGT
P
I
D
I
Y
D
E
P
I
N
K
F
V
A
D
F
IGES--NIVNG
K
M
I
Q
D
-------
F
--
E
V
-----
E
F
V
--
E
----
R
R
F
E
C
V
--D-----Q----G---F----RPN
E
V
----
V
E
V
V
I--RPE--D
L
E
---IT------S------AE------K
G
Q
L
Q
V
T
V
D
W
M
L
FRG----
V
H
Y
E
V
G
C
I
D
IDG-N-
E
W
L
V
--
H
--
T
--
T
--
R
K
--
V
RVGDKIG
L
A
FEPE
A
I
H
V
M
RLGE
T
E
E
E
F
D
K
RLDSYDEVQ
115
HHSearch
91.60
39%
-113
- C2 -
1Z47
1
?
A:
[13-354]
---
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
----
S
---
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
--------
I
-------
G
-------
G
K
R
V
----
T
-----
D
------
L
P
P
Q
------
K
R
N
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
R
----
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
---
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
--
N
V
W
T
R
A
V
Q
N
G
-------
R
---
I
-----
E
V
A
--
G
----
A
A
L
P
V
D
--------
P
----
A
---
V
----
S
E
G
S
E
----
V
A
V
V
V
--
R
P
K
--
D
V
E
---
L
Q
------
P
------
A
S
------
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
----
S
Y
S
A
C
W
I
R
T
K
D
G
-
E
-
V
W
E
V
--
H
V
P
S
AD
R
--
H
R
--
W
S
P
G
A
W
V
H
M
N
V
--
T
R
W
F
I
F
P
-------------------
131
Fugue
91.51
39%
-106
- C2 -
1Z47
1
?
A:
[11-355]
-
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
----
S
---
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
--------
I
-------
G
-------
G
K
R
V
----
T
-----
D
------
L
P
P
Q
------
K
R
N
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
R
----
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
---
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
--
N
V
W
T
R
A
-
V
Q
N
-------
G
--
R
I
-----
E
V
A
--
G
----
A
A
L
P
-
V
--
D
-----
P
----
A
---
V
----
S
E
G
S
E
----
V
A
V
V
V
--
R
P
K
--
D
V
E
---
L
Q
------
P
------
A
S
------
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
----
S
Y
S
A
C
W
I
R
T
K
D
G
-
E
-
V
W
E
V
--
H
--
V
--
P
--
S
A
DR
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
------------------
1
PsiBlast_PDB
89.83
42%
-107
- C2 -
1Z47
1
?
A:
[15-328]
-----
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
----
S
---
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
--------
I
-------
G
-------
G
K
R
V
----
T
-----
D
------
L
P
P
Q
------
K
R
N
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
R
----
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
---
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
--
N
V
W
T
-
R
A
V
Q
N
-------
G
--
R
I
-----
E
V
A
--
G
----
A
A
L
P
-
V
--
D
-----
P
----
A
---
V
----
S
E
G
S
E
----
V
A
V
V
V
--
R
P
K
--
D
V
E
---
L
Q
------
P
------
A
S
------
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
----
S
Y
S
A
C
W
I
R
T
K
D
G
-
E
-
V
W
E
V
--
H
---------------------------------------------------
2
PsiBlast_PDB
89.82
40%
-113
- C2 -
2D62
8
?
A:
[7-367]
-----
V
K
L
I
N
I
W
K
R
F
-
G
-
D
V
T
----
A
---
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
--------
I
-------
E
-------
D
N
L
V
----
A
-----
D
PEKG
V
F
V
P
P
K
------
E
R
D
V
A
M
V
F
Q
--
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
P
-
L
K
L
R
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
-
T
E
L
L
N
R
----
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
---
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
N
F
L
D
A
T
I
T
D
D
GFLDFGE
F
--
K
L
-----
K
L
L
--
Q
----
D
Q
F
E
V
L
--
E
-----
E
----
E
---
N
----
M
V
G
K
E
----
V
I
F
G
I
--
R
P
E
--
D
V
H
---
D
A
------
S
FTHIDV
P
E
------
E
N
T
V
K
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
I
S
F
T
A
-
K
----
F
--
P
--
K
--
E
--
S
K
--
V
R
E
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
-------------------
21
PsiBlast_CBE
89.39
42%
-107
- C2 -
1Z47
1
?
B:
[15-328]
-----
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
----
S
---
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
--------
I
-------
G
-------
G
K
R
V
----
T
-----
D
------
L
P
P
Q
------
K
R
N
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
R
----
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
---
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
--
N
V
W
T
-
R
A
V
Q
N
-------
G
--
R
I
-----
E
V
A
--
G
----
A
A
L
P
-
V
--
D
-----
P
----
A
---
V
----
S
E
G
S
E
----
V
A
V
V
V
--
R
P
K
--
D
V
E
---
L
Q
------
P
------
A
S
------
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
----
S
Y
S
A
C
W
I
R
T
K
D
G
-
E
-
V
W
E
V
--
H
---------------------------------------------------
3
PsiBlast_PDB
89.23
42%
-114
- C2 -
4TQU
-
?
S:
[5-323]
-----
V
S
I
Q
N
V
V
K
R
Y
D
K
-
T
T
-----
V
---
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
--------
I
-------
D
-------
G
R
V
I
----
N
-----
D
------
L
A
P
K
------
D
R
D
V
A
M
V
F
Q
--
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
-
Q
P
L
L
E
R
----
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
---
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
PM
N
L
M
P
A
R
I
A
V
D
----------
S
T
-----
Q
H
V
--
E
LNGG
N
R
I
S
L
L
--
P
-----
R
----
A
GTH
L
----
A
P
G
Q
E
----
V
V
F
G
I
--
R
P
E
--
D
V
T
LDG
V
E
------
G
------
S
E
------
R
A
Q
I
K
A
T
V
D
----------------
I
V
E
P
L
G
-
S
-
E
S
I
L
--
H
--
A
--
T
--------
V
G
D
----------------------------------
4
PsiBlast_PDB
88.12
42%
-113
- C2 -
4TQV
-
?
C:
[5-323]
-----
V
S
I
Q
N
V
V
K
R
Y
D
K
-
T
T
-----
V
---
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
--------
I
-------
D
-------
G
R
V
I
----
N
-----
D
------
L
A
P
K
------
D
R
D
V
A
M
V
F
Q
--
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
-
Q
P
L
L
E
R
----
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
---
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
V
D
----------
S
T
-----
Q
H
V
--
E
L
NGG
N
R
I
S
L
L
--
P
-----
R
----
A
GTH
L
----
A
P
G
Q
E
----
V
V
F
G
I
--
R
P
E
--
D
V
T
LDG
V
E
------
G
------
S
E
------
R
A
Q
I
K
A
T
V
D
----------------
I
V
E
P
L
G
-
S
-
E
S
I
L
--
H
--
A
--
T
--------
V
G
D
----------------------------------
22
PsiBlast_CBE
87.99
42%
-104
- C2 -
2IT1
1
?
B:
[4-330]
-----
I
K
L
E
N
I
V
K
K
F
G
N
-
F
T
-----
A
---
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
--------
F
-------
D
-------
E
K
D
V
----
T
-----
E
------
L
P
P
K
------
D
R
N
V
G
L
V
F
Q
--
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
-
D
K
L
L
N
R
----
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
---
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
V
E
A
K
-
V
E
D
-------
G
--
K
L
-----
V
I
T
--
E
----
K
S
K
L
P
I
--
P
-----
K
----
Q
---
Y
V
E
I
V
K
E
T
G
I
----
T
E
V
I
I
G
F
R
P
H
--
D
A
E
---
I
V
------
K
------
G
E
------
G
------------
E
G
----
I
V
G
E
V
Y
S
F
E
P
L
G
-
R
-
E
Q
I
V
------------
T
--
V
S
V
N
D
S
I
V
K
V
F
A
P
E
G
E
H
----------------------
5
PsiBlast_PDB
87.88
42%
-101
- C2 -
2IT1
-
?
A:
[4-330]
-----
I
K
L
E
N
I
V
K
K
F
G
N
-
F
T
-----
A
---
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
--------
F
-------
D
-------
E
K
D
V
----
T
-----
E
------
L
P
P
K
------
D
R
N
V
G
L
V
F
Q
--
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
-
D
K
L
L
N
R
----
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
---
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
V
E
A
K
-
V
E
D
-------
G
--
K
L
-----
V
I
T
--
E
----
K
S
K
L
P
I
--
P
-----
K
----
Q
---
Y
V
E
I
V
K
E
T
G
I
----
T
E
V
I
I
G
F
R
P
H
--
D
A
E
---
I
V
------
K
------
G
E
------
G
------------
E
G
----
I
V
G
E
V
Y
S
F
E
P
L
G
-
R
-
E
Q
I
V
------------
T
--
V
S
V
N
D
S
I
V
K
V
F
A
P
E
G
E
H
----------------------
116
HHSearch
86.52
36%
-102
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-362]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
----
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
--------
I
-------
G
-------
E
K
R
M
----
N
-----
D
------
T
P
P
A
------
E
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
-
A
H
L
L
D
R
----
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
-------
A
--
I
D
Q
V
Q
V
-
E
L
P
MP
N
R---
Q
Q
V
W
L
P
VE
S
-----
R
----
D
---
V
----
Q
V
G
A
N
----
M
S
L
G
I
--
R
P
E
--
H
L
L
---
P
S
------
D
------
I
A
------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
----
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
-
N
L
V
Y
--
R
--
Q
N
D
V
--
V
L
--
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
-------------
110
HHSearch
84.47
40%
-102
- C2 -
2IT1
-
?
A:
[2-354]
---
V
E
I
K
L
E
N
I
V
K
K
F
G
N
--
F
T
----
A
---
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
--------
F
-------
D
-------
E
K
D
V
----
T
-----
E
------
L
P
P
K
------
D
R
N
V
G
L
V
F
Q
--
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
-
D
K
L
L
N
R
----
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
---
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
V
E
A
K
V
E
D
G
-------
K
--
L
V
-----
I
T
E
--
K
----
S
K
L
P
I
P
--
K
QY
V
E
I
V
----
K
---
E
----
T
G
I
T
E
----
V
I
I
G
F
--
R
P
H
--
D
A
E
---
I
V
------
K
------
G
E
------
G
E
G
I
V
G
E
V
Y
S
F
E
P
L
G
----
R
E
Q
I
V
T
V
S
V
N
D
S
---
I
V
K
V
F
A
P
--
E
--
G
--
E
H
--
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
---------------
112
HHSearch
84.07
38%
-99
- C2 -
2YYZ
3
?
A:
[2-355]
---
P
S
I
R
V
V
N
L
K
K
Y
F
G
K
--
V
K
----
A
---
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
--------
F
-------
D
-------
D
V
L
V
----
N
-----
D
------
I
P
P
K
------
Y
R
E
V
G
M
V
F
Q
--
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
-
D
N
L
L
D
R
----
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
---
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
P
P
T
N
F
L
R
D
F
S
V
S
V
-------
E
NK
Q
T
I
L
---
K
R
D
--
D
----
V
I
I
K
L
P
--
E
-----
P
----
V
---
D
----
V
K
L
K
E
----
V
V
V
G
I
--
R
P
E
--
H
C
R
---
I
S
------
R
------
E
R
V
-----
E
N
S
I
P
G
V
V
Y
V
V
E
P
L
G
----
R
D
I
I
V
N
V
K
T
E
K
G
-
E
-
I
I
K
V
--
F
GD
T
--
G
--
K
A
--
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
E
---------------
118
HHSearch
82.58
33%
-102
- C2 -
1OXX
25
?
K:
[1-352]
--
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
----
A
---
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
--------
F
-------
D
-------
D
R
L
V
----
A
-----
S
NGKLI-
V
P
P
E
------
D
R
K
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
----
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
---
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
--
N
E
L
E
G
K
V
T
N
E
-------
G
--
V
V
------
I
G
--
S
------
L
R
F
P
-------------
V
---
S
----
V
S
S
D
R
----
A
I
I
G
I
--
R
P
E
--
D
V
K
---
L
S
------
K
------
D
V
IKDDSW
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
----
G
L
F
R
I
T
I
T
P
L
D
S
-
E
E
E
I
F
T
--
Y
--
S
--
D
--
H
P
--
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
------------------
111
HHSearch
81.03
39%
-105
- C2 -
1V43
-
?
A:
[10-369]
--
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
--
F
T
----
A
---
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
--------
F
-------
G
-------
D
R
D
V
----
T
-----
Y
------
L
P
P
K
------
D
R
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
-
E
E
L
L
N
R
----
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
EM
N
I
L
E
V
S
V
G
D
G
-------
Y
--
L
------
E
G
R
--
G
----
F
R
I
E
L
P
--
Q
------MDLL
K
---
D
----
Y
V
G
K
T
----
V
L
F
G
I
--
R
P
E
--
H
M
T
---
V
E
------
G
------
V
-HMK
R
--
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
----
T
D
T
I
L
H
V
K
F
G
D
E
---
L
V
K
V
--
K
L
P
G
--
H
--
I
P
--
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
---------------
133
Fugue
80.51
34%
-90
- C2 -
1OXS
23
?
C:
[1-352]
--
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
----
A
---
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
--------
F
-------
D
-------
D
R
L
V
----
A
SNGKL
I
------
V
P
P
E
------
D
R
K
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
----
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
---
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
--
N
E
L
E
G
K
V
T
N
E
----------
G
V
-----
V
I
G
--
S
----
L
R
F
P
---------------
V
---
S
----
V
S
S
D
R
----
A
I
I
G
I
--
R
P
E
--
D
V
K
---
L
S
KDVIKD
D
------
S
W
------
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
-----
G
L
F
R
I
T
I
T
P
L
D
-
S
-
E
E
E
I
--
F
--
T
--
Y
SD
H
P
--
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
------------------
8
PsiBlast_PDB
76.80
43%
-101
- C2 -
2YYZ
3
?
A:
[4-288]
-----
I
R
V
V
N
L
K
K
Y
F
G
K
-
V
K
A
----
V
----
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
--------
F
-------
D
-------
D
V
L
V
----
N
-----
D
------
I
P
P
K
------
Y
R
E
V
G
M
V
F
Q
--
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
-
D
N
L
L
D
R
----
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
---
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
P
--
P
T
---
N
F
L
R
D
-------
F
--
S
V
S
V
E
NK
Q
T
I
--
L
----
K
R
D
D
V
I
--
I
-----
K
----
L
---
P
----
E
P
V
D
V
KLK
E
V
V
V
G
I
--
R
P
E
--
H
C
R
---
I
S
-----------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
76.45
38%
-103
- C2 -
1OXV
15
?
D:
[4-284]
-----
I
I
V
K
N
V
S
K
V
F
K
K
-
G
K
V
----
V
A--
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
--------
F
-------
D
-------
D
R
L
V
----
A
-----
S
NGKLI-
V
P
P
E
------
D
R
K
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
----
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
---
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
--
N
E
L
E
G
K
V
T
N
E
----------
G
V
-----
V
I
G
--
S
----
L
R
F
P
V
S
--
V
-----
S
----
S
---
D
----
R
--------
A
I
I
G
I
--
R
P
E
--
D
V
K
---
L
S
-----------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.72
45%
-114
- C2 -
3PUZ
2
MALK_ECOLI
B:
[4-239]
-----
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
V
----
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
--------
I
-------
G
-------
E
K
R
M
----
N
-----
D
------
T
P
P
A
------
E
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
-
A
H
L
L
D
R
----
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.60
45%
-116
- C2 -
3PUV
5
MALK_ECOLI
A:
[4-239]
-----
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
V
----
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
--------
I
-------
G
-------
E
K
R
M
----
N
-----
D
------
T
P
P
A
------
E
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
-
A
H
L
L
D
R
----
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.52
45%
-113
- C2 -
3PUY
3
MALK_ECOLI
A:
[4-239]
-----
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
V
----
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
--------
I
-------
G
-------
E
K
R
M
----
N
-----
D
------
T
P
P
A
------
E
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
-
A
H
L
L
D
R
----
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
73.01
33%
-95
- C2 -
3FVQ
3
FBPC_NEIG1
B:
[5-311]
-----
L
H
I
G
H
L
S
K
S
F
Q
N
-
T
P
-----
V
---
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
--------
L
-------
S
-------
G
K
T
I
FSKN
T
-----
N
------
L
P
V
R
------
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
-
S
E
L
A
G
R
----
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
---
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
--
I
V
F
P
A
A
L
N
A
D
-------
G
--
T
A
-----
D
C
R
--
L
----
G
R
L
P
-
V
--
Q
-----
S
----
G
---
A
----
P
A
G
T
R
----
G
T
L
L
I
--
R
P
E
QY
S
L
H
---
P
H
------
S
------
A
P
------
A
A
S
I
H
A
V
V
L
K
T
T
P
K
A
----
R
H
T
E
I
--------------------------------------------------------------------
52
PsiBlast_CBE
72.65
33%
-97
- C2 -
3FVQ
3
FBPC_NEIG1
A:
[5-316]
-----
L
H
I
G
H
L
S
K
S
F
Q
N
-
T
P
-----
V
---
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
--------
L
-------
S
-------
G
K
T
I
FSKN
T
-----
N
------
L
P
V
R
------
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
-
S
E
L
A
G
R
----
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
---
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
--
I
V
F
P
A
A
L
N
A
D
-------
G
--
T
A
-----
D
C
R
--
L
----
G
R
L
P
-
V
--
Q
-----
S
----
G
---
A
----
P
A
G
T
R
----
G
T
L
L
I
--
R
P
E
Q
Y
S
L
H
---
P
H
------
S
------
A
P
------
A
A
S
I
H
A
V
V
L
K
T
T
P
K
A
----
R
H
T
E
I
--------------------------------------------------------------------
61
PsiBlast_CBE
62.58
33%
-103
- C2 -
4U00
3
?
A:
[3-238]
---
P
I
I
R
I
R
N
L
H
K
W
F
-
G
-
P
L
H
----
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
--------
V
-------
D
GLSVKD-
D
R
A
L
----
R
-----
E
------
I
---------
R
R
E
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
Q
A
R
K
----
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
----
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
56.61
33%
-99
- C2 -
3C41
3
?
K:
[18-240]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
-------
D
GINLKAK
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
56.39
33%
-94
- C2 -
2OLK
1
?
D:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
56.22
35%
-98
- C2 -
4YMU
2
?
A:
[16-238]
-------------------------
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
--------
I
-------
D
-------
G
V
K
I
----
N
-----
N
------
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
Q
----
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
56.04
33%
-98
- C2 -
2OLJ
4
?
A:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
55.93
35%
-94
- C2 -
4YMV
1
?
J:
[16-238]
-------------------------
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
--------
I
-------
D
-------
G
V
K
I
----
N
-----
N
------
G
K
V
N
INKV--
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
Q
----
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
55.52
33%
-97
- C2 -
3C4J
4
?
B:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.32
33%
-94
- C2 -
2OLK
2
?
B:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
55.29
35%
-96
- C2 -
4YMU
2
?
J:
[16-238]
-------------------------
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
--------
I
-------
D
-------
G
V
K
I
----
N
-----
N
------
G
K
V
N
INKV--
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
Q
----
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
55.28
33%
-98
- C2 -
2OLK
1
?
C:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
55.18
32%
-97
- C2 -
3TIF
7
Y796_METJA
B:
[1-225]
----
M
V
K
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
----
I
IYA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
--------
I
-------
D
-------
N
I
K
T
----
N
-----
D
------
L
D
D
D
ELTKIR
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
-
A
E
L
E
E
R
FANH
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
---
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
55.09
35%
-92
- C2 -
4YMV
1
?
A:
[16-238]
-------------------------
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
--------
I
-------
D
-------
G
V
K
I
----
N
-----
N
------
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
Q
----
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
55.04
33%
-99
- C2 -
2OLK
1
?
A:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.82
33%
-98
- C2 -
2Q0H
4
?
B:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
54.48
33%
-92
- C2 -
3C41
3
?
J:
[18-240]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
-------
D
GINLKAK
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
54.32
33%
-88
- C2 -
2OLJ
3
?
B:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.32
33%
-95
- C2 -
2Q0H
4
?
A:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
53.46
34%
-95
- C2 -
1L2T
4
Y796_METJA
B:
[1-225]
----
M
I
K
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
----
I
IYA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
IDNIKTND
L
-------
D
-------
D
D
E
L
----
T
-----
K
------
I
R
R
D
------
K
--
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
-
A
E
L
E
E
R
FANH
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
---
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
53.29
33%
-90
- C2 -
3C4J
3
?
A:
[39-261]
-------------------------
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
--------
I
DGINLKA
K
-------
D
T
N
L
----
N
-----
K
------
V
---------
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
----
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
53.22
32%
-95
- C2 -
4MKI
4
ECFA2_CALS4
A:
[7-238]
-----
I
K
V
E
N
V
S
F
I
Y
N
E
-
G
T
P
YATV
A
---
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
--------
I
-------
N
GIDIT--
D
K
K
V
----
S
------------
L
K
D
I
------
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
-
P
S
N
L
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
----
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
---
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
52.69
32%
-93
- C2 -
4MKI
4
ECFA2_CALS4
B:
[7-238]
-----
I
K
V
E
N
V
S
F
I
Y
N
E
-
G
T
P
YATV
A
---
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
--------
I
-------
N
GIDIT--
D
K
K
V
----
S
------------
L
K
D
I
------
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
-
P
S
N
L
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
----
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
---
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------