@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0814: (2016-03-18 )
MSITNLLNIKYPIIQGAMAQIAKAPLVAAVSNAGGLGIIASGGMTADMLREEIQKTKALTDKAFGVNLMLMMTNIAELTEVIIEEKVGIVTTGAGTPKTFMPIWKEAGIIVIPVVPSVMIAKRMEKMGADAVIAEGTEAGGHVGETTTMALLPQIVDAVTIPVIGAGGIADGRGIVAALALGAKGVQIGTRFLATDECPVHPDFKAAVIKASDRDTMVTGRKAGAPVRSIKNKMIKEYIRLEEENADRDTLEELTLGSLRKAVQEGDTDNGSVMAGQIAGLITEIKPCKDVIEEMMTDAKKVIAGLELK
Atome Classification :
(20 SA)
---.........10........20........30........40..-.-.....50........60........70..----.----...--------------------------------------..80........90......-..100.......110.......120.......130.......140..---------.--...--.150.......160.......170.......180.......190.......200.......210.......220.......230.......240-----..-.--.-...250...-.-...-260.......270.......280.......290.......300.......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MSI
T
N
L
LNIK
Y
P
I
I
Q
G
A
M
A
Q
I
A
KA
P
L
V
A
A
VSNAG
G
L
G
I
IASGG-M-
T
A
D
M
L
R
E
E
I
Q
K
T
K
A
LTDKAFGV
N
L
M
L
M
M
T
----
N
----
I
A
E
--------------------------------------
L
T
E
V
I
I
E
EKV
G
I
V
TTGAGTP-KT
F
M
P
I
W
KEA
G
I
I
V
I
PVV
P
S
V
M
I
A
K
R
M
E
K
MGA
D
A
V
I
AEGTEAGGHVG---------
E
--
T
T
T
--
M
A
L
L
P
Q
I
V
D
A
VT
I
P
V
I
GAGGIADG
R
G
I
V
A
A
L
A
LGAK
G
V
Q
I
G
T
R
F
LATDECPVHPDF
K
A
A
V
I
KASDRD
T
M
VTGRKAGA
P
V
R
S
I
K
N
K
M
I
K
E
Y
I
R
LE-----EE-N--A-
D
R
D
T
L
E
E
L
T
-
L
-
G
S
L
-
R
K
A
V
QEGDTDNGS
V
M
A
G
Q
I
A
G
L
I
TE
I
K
P
C
K
D
V
I
E
E
M
M
T
D
A
K
K
V
I
AGLELK---
103
HHSearch
98.93
51%
-109
- C4 -
3BO9
13
?
A:
[17-321]
---
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
-
K
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
P
----
W
----
A
D
D
--------------------------------------
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
--
V
T
T
--
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
-----
F
E
-
N
--
P
-
M
--
Q
A
E
E
M
L
-
V
-
G
S
L
-
R
R
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
-----
3
PsiBlast_PDB
97.55
50%
-109
- C4 -
3BO9
13
?
A:
[19-320]
-----
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
-
K
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
P
----
W
----
A
D
D
--------------------------------------
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
--
V
T
T
--
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
-----
F
E
-
N
--
P
-
M
Q
--
A
E
E
M
L
-
V
-
G
S
L
-
R
R
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
------
102
HHSearch
96.29
50%
-105
* C4 *
2Z6I
5
?
A:
[3-314]
---
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
-
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
----
F
----
V
E
D
--------------------------------------
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
--
L
T
T
--
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
-----
K
D
-
A
F
-
K
Q
D
L
E
I
F
E
Q
M
G
-
A
-
G
A
L
-
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
-----
2
PsiBlast_PDB
93.35
48%
-106
- C4 -
2Z6I
5
?
A:
[5-310]
-----
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
-
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
----
F
----
V
E
D
--------------------------------------
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
--
L
T
T
--
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F
K
Q
-------
D
L
E
I
F
E
Q
M
G
-
A
-
G
A
L
-
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
---------
21
PsiBlast_CBE
91.88
50%
-108
- C4 -
2Z6J
4
?
B:
[5-310]
-----
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
-
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
----
F
----
V
E
D
--------------------------------------
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
--
L
T
T
--
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
----
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
AF--------------
E
Q
M
G
-
A
-
G
A
L
-
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
---------
1
PsiBlast_PDB
91.58
50%
-109
- C4 -
2Z6J
5
?
A:
[5-310]
-----
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
-
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
----
F
----
V
E
D
--------------------------------------
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
--
L
T
T
--
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
---
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
AF--------------
E
Q
M
G
-
A
-
G
A
L
-
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
---------
4
PsiBlast_PDB
90.73
42%
-101
- C4 -
4IQL
7
?
A:
[24-329]
-----
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
-
M
-
H
P
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
L
Y
P
----
E
----
M
D
K
--------------------------------------
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
RE-------
E
--
T
T
T
--
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
-
L
K
A
V
S
P
T
R
L
L
K
N
K
F
Y
Q
D
V
F
A
A
E
-----
Q
R
-
G
--
A
-
S
V
E
E
L
R
E
L
L
G
R
-
G
R
A
-
K
Q
G
I
F
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
A
G
M
------
22
PsiBlast_CBE
90.32
42%
-102
- C4 -
4IQL
6
?
B:
[24-329]
-----
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
-
M
-
H
P
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
L
Y
P
----
E
----
M
D
K
--------------------------------------
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
RE-------
E
--
T
T
T
--
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
-
L
K
A
V
S
P
T
R
L
L
K
N
K
F
Y
Q
D
V
F
A
A
E
-----
Q
R
-
G
--
A
-
S
V
E
E
L
R
E
L
L
G
R
-
G
R
A
-
K
Q
G
I
F
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
A
G
M
------
104
HHSearch
89.02
36%
-103
- C4 -
2GJL
1
2NPD_PSEAE
A:
[6-320]
---
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
P
-
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
QKPV
P
----
Y
A
E
--------------------------------------
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD
I
P
G
--
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
-----
A
R
-
G
--
G
A
G
Y
A
D
I
A
A
L
V
-
S
G
Q
R
G
-
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
------
6
PsiBlast_PDB
87.97
36%
-102
- C4 -
2GJN
2
2NPD_PSEAE
A:
[8-317]
-----
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
----
Q
KPVP
Y
A
E
--------------------------------------
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
--
D
D
I
PG
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
-----
A
R
G
G
--
A
-
G
Y
A
D
I
A
A
L
V
-
S
-
G
Q
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
---------
5
PsiBlast_PDB
87.88
36%
-103
- C4 -
2GJL
1
2NPD_PSEAE
A:
[8-317]
-----
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
----
Q
KPVP
Y
A
E
--------------------------------------
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
--
D
D
I
PG
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
-----
A
R
G
G
--
A
-
G
Y
A
D
I
A
A
L
V
-
S
-
G
Q
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
---------
125
Fugue
86.87
35%
-100
- C4 -
2GJL
1
2NPD_PSEAE
A:
[3-326]
VFR
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
----
Q
KPVP
Y
A
E
--------------------------------------
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
ED-------
D
--
I
P
G
--
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
-----
A
R
-
G
GA
G
-
Y
A
D
I
A
A
L
V
S
-
G
-
Q
R
G
-
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
8
PsiBlast_PDB
78.92
32%
-108
- C4 -
4Q4K
1
?
A:
[5-285]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
----
G
----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
VFEPERGDA
A
--
I
G
T
--
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
-----------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.49
32%
-107
- C4 -
4QIS
1
?
B:
[10-290]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
----
G
----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
VFEPERGDA
A
--
I
G
T
--
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
-----------------------------------------------------------------------------------------
26
PsiBlast_CBE
78.36
32%
-109
- C4 -
4QIU
2
?
B:
[10-290]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
----
G
----
Q
A
D
PARERAWLDYLKPLFAEFGAEPPVRLKNIYLSFLEDPT
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
VFEPERGDA
A
--
I
G
T
--
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
-----------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.15
32%
-107
- C4 -
4Q4K
1
?
B:
[5-285]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
----
G
----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
VFEPERGDA
A
--
I
G
T
--
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
-----------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.84
32%
-108
- C4 -
4QIU
2
?
A:
[10-290]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
----
G
----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
VFEPERGDA
A
--
I
G
T
--
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
-----------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.78
32%
-110
- C4 -
4QIS
1
?
A:
[10-290]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
----
G
----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
VFEPERGDA
A
--
I
G
T
--
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
-----------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.30
32%
-111
- C4 -
4QIT
2
?
B:
[11-291]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
----
G
----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
VFEPERGDA
A
--
I
G
T
--
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
-----------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.66
32%
-107
- C4 -
4QIT
2
?
A:
[11-291]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
-
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
----
G
----
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
VFEPERGDA
A
--
I
G
T
--
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
-----------------------------------------------------------------------------------------