@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0818: (2016-03-18 )
MLWVKESIEQLLSKLHTNLDTGLTKEQVKQKHAEFGTNEFEEGKKESLLQKIGHHLVEITTIVLLFAAAISAYLAITTGYGWAKVVVILGIVVLNMVLGIYQENSAEKALAALQSMNAHLTTVIRDGVRMQVDATELVPGDIIEIVAGDMIPADARIISSSSLQVEESALTGESVPVEKDANAVVSEKAPIGDRLNMLYSGCLVTNGRATAVVVEIGMETEMGKIAGLLNSTSKLMTPLQLRLKELAKRLSIVALLAGILIFIIDVYVYGETIIETLMIAISLAVAAVPETLPVIVTLTLAYGVQNMVRKNTIIRRIPAVETIGNTSVICSDKTGTLTQNKMIIQQIWAADHTPIKATAEFDTAEQKVLEMLSLSSNATIDVTDGEETIIGDPTESAIIRLLEEKGTTKKALEAKYPRVFELPFDSDRKLMTTIHQVEDGFLSITKGAFDRIPVNFSEAFLAEAERVHDSFAEDALRVLVVAYKKYPEMPTDLSSEALETDLTFAGMVGMIDPPRPESKAAVLAAKKAGIKTVMITGDHIVTASAIAKEIGILTDGDKAITGAELAEMSEADLEKNIRDYAVYARVSPEDKIRIVKAWQKNGEIVTMTGDGVNDAPALKAADVGAAMGITGTDVSKNAADMVITDDNFATIVDAVKEGRTAYENIRKTIYFLLSTNFSQIFIMLIAIILGWGAPVVAVQLLLINVVSDGIPGFFLSREKADDSIMERKPIPKNAGIFANGLGKKMATQAVVFTIVTLAGFYIGQFVTINNSIGASYEVGMTMAFVILAWSSVAHIFNVRSDKSIFTIGFLSNRGLFFSAICSMLIILGLAIIPPLANMFFLVEMSLTHWILAFILSMFPLLFVEIQKLIQRKRAKA
Atome Classification :
(40 SA)
..-.......10........20........30........40-.........50........60........70.....-----..-----.80........90........100.......110.......120.....--.--.--130.......140.......150.....--..--160.........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.....---------..-----270---..---------......280.......290.......300.......310.......320.......330.......340.......350--------.----------------------------.....--------.-------360--.-------........370----------------.........380--..--.....390.......400..----------------..----------------...410---------------........420.......430..------...------..------440.......450------------...------------..--..------------..460.......470--.......480.....----..490------...------...--.500.......510.......520.......530.......540.......550...----.----.----..560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......-730.......740.......750.......-760------.-------------------------...-...770---------------------..--------......--------------------------.780.......790.......800-........810.......820.......830.......840.......850.......860.......870....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML-
W
V
K
E
S
I
E
Q
L
L
S
K
L
HTNLDTGL
T
K
E
Q
V
K
Q
K
H
AEFG
T
N
E
F
--EE
G
K
K
E
S
L
L
Q
K
I
G
H
H
L
V
E
I
T
T
I
V
L
L
F
A
A
A
I
S
A
Y
L
A
I
-----TT-----GY
G
W
A
K
V
V
V
I
L
G
I
V
V
L
N
M
V
L
G
I
YQEN
S
A
E
K
A
L
A
A
L
Q
S
M
N
A
H
L
T
T
V
I
RDG--
V
--
R
--
M
Q
V
D
A
TELVP
G
D
I
I
E
I
VAGDMIPAD
A
R
I
--IS--S--SS
L
Q
V
E
ESALTGESVPVEKDA
N
A
VVSEKAP
I
G
D
R
L
N
M
L
YS
G
C
L
V
TNGR
A
T
A
V
V
V
E
IGMET
E
M
G
K
I
A
G
L
L
N
S
T
S
K
L
M
T
P
L
Q
L
R
L
K
E
L
A
K
R
L
S
I
V
A
L
L
A
G
I
L
I
F
I
I
D
V
Y
---------VY-----
G
E
----
T
I
---------
I
E
T
L
M
I
A
I
S
L
A
V
A
AVPET
L
P
V
I
V
T
L
T
L
A
Y
G
V
Q
N
M
V
R
K
N
T
I
I
RRIPAVETIGN
T
S
V
I
CSDKTGTLTQ
N
K
M
I
I
Q
Q
I
WAADH--------T----------------------------P
I
K
A
T--------A-------E----F-------D
T
A
E
Q
K
V
L
E
------------------
M
L
SLSSN
A
T
I
D
V--TD--GEE
T
I
IGDP
T
E
S
A
I
I
R
L
L
E
E----------------KG----------------TTK
K
A
----------------LEAKY
P
R
V
F
ELPFDSD
R
K
L
M
T
T
I
------
H
Q
V------ED------
G
F
L
S
ITKGAFD--------------RIP------------V
N
--
F
S
------------
E
A
F
L
A
E
A
E
R
V
H
D
S
F
A
--
E
D
A
L
R
V
L
V
V
A
Y
K
KYP----EMPTD------L
S
S
------
E
A
L
--
E
TD
L
T
F
AGMVGMIDPPRPES
K
A
A
V
L
A
AKKAG
I
K
T
V
M
I
TGD
H
I
V
T
A
S
A
I
A
K
E
IGILTD----G----D----KAI
T
G
A
E
L
A
E
M
S
E
A
D
L
E
KN
I
R
D
Y
A
V
Y
A
RVSPED
K
I
R
I
V
K
A
W
QKNG
E
I
V
T
M
TGDGVNDAPALKAADVGAAMGITGTDVSKNA
A
D
M
V
I
TDD
N
F
A
T
I
V
D
A
V
K
E
G
R
T
A
Y
E
N
I
R
K
T
I
Y
F
L
LST
N
F
S
Q
I
F
I
M
L
I
A
I
I
LGWG
A
P
V
V
A
V
Q
L
L
L
I
N
V
V
SDGIP
G
F
F
LSREKAD
D
S
I
MERKP-IPKNA
G
I
FANGLG
K
K
M
A
T
Q
A
V
V
F
T
I
V
T
L
A
G
-
F
Y
I------G-------------------------
Q
F
V
-
T
I
NN-----------------------SI--------GA
S
Y
E
V
--------------------------
G
M
T
M
A
F
V
I
L
A
W
S
S
V
A
H
I
F
NVRS-D-
K
S
I
F
T
I
G
FLSNR
G
L
F
F
S
A
I
C
S
M
L
I
I
L
G
L
A
I
IP
P
L
A
N
M
F
F
L
V
E
M
S
L
T
H
W
I
L
A
F
I
L
S
M
F
P
L
L
F
V
E
I
Q
K
L
I
Q
R
K
RAKA
60
PsiBlast_CBE
92.24
32%
-95
- C2 -
2AGV
6
AT2A1_RABIT
B:
[7-989]
------
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
PA
E
E
G
K
--
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEEGE
E
T
-----
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
--
R
--
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
--
L
S
IK
S
--
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
---------
H
F
-----
N
D
----
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
--------
V
DGDFCSLNEFSITGSTYAPEGEVLKNDK
P
I
R
-
S
--------
G
-------
Q
----
F
-------
D
G
L
V
E
-
L
A
T
------------------
I
C
A
L
C
N
D
S
S
L
D
F
NE
T
K
--
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
MNVFNTEVRNLSKVER
A
N
----------------
A
C
N
S
V
----------------
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
CSPAKS
S
R
A
------
A
V
------
G
N
K
M
F
V
K
G
A
P
E
GVIDRCNYVRVGTT
R
V
P
------------
M
T
GP
V
K
------------
E
K
I
L
S
V
I
K
E
W
--
G
T
G
--
R
D
T
L
R
C
L
A
L
A
T
R
D
T
P
PKRE
E
M
V
L
D
------
D
S
S
------
R
F
M
EY
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
----
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
--
Y
V
G
A
A
T
V
G
-
A
A
A
------
W
-------------------------
W
F
M
-
Y
A
E
D
-----------------------
G
P
--------
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAPE
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
-
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
-----
10
PsiBlast_PDB
92.10
32%
-95
- C2 -
2AGV
6
AT2A1_RABIT
A:
[7-989]
------
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
PA
E
E
G
K
--
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEEGE
E
T
-----
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
--
R
--
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
--
L
S
IK
S
--
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
---------
H
F
-----
N
D
----
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
--------
V
DGD
F
C
S
L
N
E
F
S
I
T
G
STYAPE
G
E
V
L
K
ND
K
P
I
R
-
S
--------
G
-------
Q
----
F
-------
D
G
L
V
E
-
L
A
T
------------------
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
--
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLSKVER
A
N
----------------
A
C
N
S
V
----------------
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
AKS
S
R
A
------
A
V
------
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
CN
Y
V
R
V
GT
T
R
V
P
------------
M
T
G
P
V
K
------------
E
K
I
L
S
V
I
K
E
W
--
G
T
G
--
R
D
T
L
R
C
L
A
L
A
T
R
D
T
P
PKRE
E
M
V
L
D
------
D
S
S
------
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
----
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
--
Y
V
G
A
A
T
V
G
-
A
A
A
------
W
-------------------------
W
F
M
-
Y
A
E
D
-----------------------
G
P
--------
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
-
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
-----
20
PsiBlast_PDB
91.87
32%
-93
- C2 -
2EAU
5
AT2A1_RABIT
A:
[7-989]
------
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
PA
E
E
G
K
--
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EEGE
E
T
-----
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
--
R
--
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
--
L
S
IK
S
--
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
---------
H
F
-----
N
D
----
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
--------
V
DGD
F
C
S
L
N
E
F
S
I
T
G
STYAP
E
G
E
V
L
K
ND
K
P
I
R
-
S
--------
G
-------
Q
----
F
-------
D
G
L
V
E
-
L
A
T
------------------
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
--
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLSKVER
A
N
----------------
A
C
N
S
V
----------------
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
AKS
S
R
A
------
A
V
------
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
CN
Y
V
R
V
GT
T
R
V
P
------------
M
T
G
P
V
K
------------
E
K
I
L
S
V
I
K
E
W
--
G
T
G
--
R
D
T
L
R
C
L
A
L
A
T
R
D
T
P
PKRE
E
M
V
L
D
------
D
S
S
------
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
----
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
--
Y
V
G
A
A
T
V
G
-
A
A
A
------
W
-------------------------
W
F
M
-
Y
A
E
D
-----------------------
G
P
--------
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
-
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
-----
55
PsiBlast_CBE
91.47
32%
-94
- C2 -
2YFY
3
?
A:
[7-989]
------
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
PA
E
E
G
K
--
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EEGE
E
T
-----
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
--
R
--
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
--
L
S
IK
S
--
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
---------
H
F
-----
N
D
----
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
--------
V
DGD
F
C
S
L
N
E
F
S
I
T
G
STYAP
E
G
E
V
L
K
NDK
P
I
R
-
S
--------
G
-------
Q
----
F
-------
D
G
L
V
E
-
L
A
T
------------------
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
--
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLS
K
V
E
R
A
N
----------------
A
C
N
S
V
----------------
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
PAKS
S
R
A
------
A
V
------
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
CN
Y
V
R
V
GT
T
R
V
P
------------
M
T
G
P
V
K
------------
E
K
I
L
S
V
I
K
E
W
--
G
T
G
--
R
D
T
L
R
C
L
A
L
A
T
R
D
T
P
PKRE
E
M
V
L
D
------
D
S
S
------
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
----
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
--
Y
V
G
A
A
T
V
G
-
A
A
A
------
W
-------------------------
W
F
M
-
Y
A
E
D
-----------------------
G
P
--------
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
-
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
-----
66
PsiBlast_CBE
91.22
32%
-99
- C2 -
3W5B
6
AT2A1_RABIT
A:
[13-996]
------
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
PA
E
E
G
K
--
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EEGE
E
T
-----
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
--
R
--
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
--
L
S
IK
S
--
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
---------
H
F
-----
N
D
----
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
--------
V
DGDF
C
S
L
N
E
F
S
I
T
G
STYAPE
G
E
V
L
K
ND
K
P
I
R
-
S
--------
G
-------
Q
----
F
-------
D
G
L
V
E
-
L
A
T
------------------
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
--
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLS
K
V
E
R
A
N
----------------
A
C
N
S
V
----------------
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
KS
S
R
A
------
A
V
------
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
CNYVRVGTT
R
V
P
------------
M
T
G
P
V
K
------------
E
K
I
L
S
V
I
K
E
W
--
G
T
G
--
R
D
T
L
R
C
L
A
L
A
T
R
D
T
P
PKRE
E
M
V
L
D
------
D
S
S
------
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
----
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
--
Y
V
G
A
A
T
V
G
-
A
A
A
------
W
-------------------------
W
F
M
-
Y
A
E
D
-----------------------
G
P
--------
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
-
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
----
26
PsiBlast_CBE
91.17
32%
-93
- C2 -
4J2T
3
AT2A1_RABIT
A:
[7-989]
------
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
PA
E
E
G
K
--
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EEGE
E
T
-----
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
--
R
--
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
--
L
S
IK
S
--
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
---------
H
F
-----
N
D
----
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
--------
V
DGD
F
C
S
L
N
E
F
S
I
T
G
STYAP
E
G
E
V
L
K
NDK
P
I
R
-
S
--------
G
-------
Q
----
F
-------
D
G
L
V
E
-
L
A
T
------------------
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
--
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLSKVER
A
N
----------------
A
C
N
S
V
----------------
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
PAKS
S
R
A
------
A
V
------
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
CNYVRVGT
T
R
V
P
------------
M
T
G
P
V
K
------------
E
K
I
L
S
V
I
K
E
W
--
G
T
G
--
R
D
T
L
R
C
L
A
L
A
T
R
D
T
P
PKRE
E
M
V
L
D
------
D
S
S
------
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
----
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
--
Y
V
G
A
A
T
V
G
-
A
A
A
------
W
-------------------------
W
F
M
-
Y
A
E
D
-----------------------
G
P
--------
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
-
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
-----
39
PsiBlast_CBE
91.00
32%
-92
- C2 -
3FGO
8
?
B:
[7-989]
------
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
PA
E
E
G
K
--
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEEGE
E
T
-----
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
--
R
--
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
--
L
S
IK
S
--
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
---------
H
F
-----
N
D
----
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
--------
V
DGDFCSLNEFSITGSTYAPEGEVLKNDK
P
I
R
-
S
--------
G
-------
Q
----
F
-------
D
G
L
V
E
-
L
A
T
------------------
I
C
A
L
C
N
D
S
S
L
D
F
NE
T
K
--
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
MNVFNTEVRNLSKVER
A
N
----------------
A
C
N
S
V
----------------
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
CSPAKS
S
R
A
------
A
V
------
G
N
K
M
F
V
K
G
A
P
E
GVIDRCNYVRVGTT
R
V
P
------------
M
T
GP
V
K
------------
E
K
I
L
S
V
I
K
E
W
--
G
T
G
--
R
D
T
L
R
C
L
A
L
A
T
R
D
T
P
PKRE
E
M
V
L
D
------
D
S
S
------
R
F
M
EY
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
----
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
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T
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M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
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I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
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M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
--
Y
V
G
A
A
T
V
G
-
A
A
A
------
W
-------------------------
W
F
M
-
Y
A
E
D
-----------------------
G
P
--------
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAPE
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
-
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
-----