@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0823: (2016-03-18 )
LNLKDTVKLANGVEMPRLGFGVWKVQDGDEAVNSVKWAIEAGYISIDTAAAYKNEEGVGQAIKESGIKREDLFVTTKLWNAEQGYESTLAAFDESLRKLELDYVDLYLIHWPVKGKFKDTWRAFEKLYKDKRVRAIGVCNFHEHHLKELMEDAEIAPMVNQIELHPQLTQEPLRKFCAENNIVVEAWSPLGNGKLLSNPEIKAIADAHGKSVAQVILRWDLQIGVVTIPKSVHQERIIQNADIFDFELTEEEVAKISGLNKDERTGPDPDNFNF
Atome Classification :
(97 SA)
.........-10........20..---....--..30........40........50........60..----.----.-----....70........80........90........100.......110.--------------------.--------------------.--------------------.--------------------...--------------------120.......130.......140.......150.---...--...160.......170.......180.......190---------.-------..-----------.-.--------.---------..200.......210.......220.......230.......240.......250.......260....---....270..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LNL
K
D
T
V
K
L-ANGVEMPRLG
F
G
V
W
---
K
VQD--G
D
E
A
V
N
S
V
K
W
A
I
E
A
G
Y
I
S
I
DTAAAYKNE
E
G
V
G
Q
A
I
K
----
E
----S-----GIKRE
D
L
F
V
T
T
KLWNAEQ
G
Y
E
S
T
L
A
A
F
D
E
S
L
R
K
L
E
L
D
Y
V
D
L
Y
L
I
H
WPV--------------------K--------------------G--------------------K--------------------
F
K
D
--------------------
T
W
R
A
F
E
K
L
Y
KDK
R
V
R
A
I
G
VCN
F
H
E
H
H
L
K
E
L
M
E
DA---EIA--
P
M
V
N
Q
IELH
P
Q
L
T
Q
E
P
L
R
K
F
C
AEN
N
I
V
V
E
A
WSPLG----------N-------GK-----------L-L--------S---------NPE
I
K
A
I
A
D
AH
G
K
S
V
A
Q
V
I
L
RWD
L
Q
I
G
V
V
TI
P
K
S
V
H
Q
E
R
I
IQNAD
I
F
D
F
EL
T
E
E
E
V
A
K
ISGLN-KDERT---GPDPDNFNF
2
PsiBlast_PDB
95.66
67%
-85
- C5 -
3D3F
1
GR_BACSU
A:
[3-275]
-
S
L
K
D
T
V
K
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
----
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
D
--------------------
K
--------------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
---
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-----------
L
-
L
--------
D
---------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
---
G
P
N
P
D
E
L
L
F
1
PsiBlast_PDB
95.35
67%
-89
- C5 -
3F7J
8
GR_BACSU
A:
[4-276]
-
S
L
K
D
T
V
K
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
----
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
D
--------------------
K
--------------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
---
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-----------
L
-
L
--------
D
---------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
---
G
P
N
P
D
E
L
L
F
21
PsiBlast_CBE
95.14
67%
-88
- C5 -
3F7J
7
GR_BACSU
B:
[4-276]
-
S
L
K
D
T
V
K
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
----
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
D
--------------------
K
--------------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
---
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-----------
L
-
L
--------
D
---------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
---
G
P
N
P
D
E
L
L
F
104
HHSearch
94.64
67%
-89
- C5 -
3F7J
8
GR_BACSU
A:
[5-276]
--
L
K
D
T
V
K
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
----
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
D
--------------------
K
--------------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
---
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-------------
L
L-------
D
---------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
---
G
P
N
P
D
E
L
L
F
8
PsiBlast_PDB
94.60
58%
-93
- C5 -
3B3D
1
YTBE_BACSU
A:
[38-314]
-
H
L
Q
A
K
A
T
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
Q
V
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
----
E
G
I
E
E
A
-----
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
V
--------------------
E
--------------------
G
--------------------
K
--------------------
Y
K
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
---
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-----------
L
-
L
--------
D
---------
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
N
L
R
V
---
G
P
D
P
D
N
F
D
F
27
PsiBlast_CBE
94.55
58%
-92
- C5 -
3B3D
1
YTBE_BACSU
C:
[38-314]
-
H
L
Q
A
K
A
T
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
Q
V
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
----
E
GIEE
A
-----
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
V
--------------------
E
--------------------
G
--------------------
K
--------------------
Y
K
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
---
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-----------
L
-
L
--------
D
---------
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
N
L
R
V
---
G
P
D
P
D
N
F
D
F
28
PsiBlast_CBE
93.71
58%
-93
- C5 -
3B3D
1
YTBE_BACSU
B:
[38-314]
-
H
L
Q
A
K
A
T
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
Q
V
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
----
E
G
I
E
E
A
-----
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
V
--------------------
E
--------------------
G
--------------------
K
--------------------
Y
K
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
---
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-----------
L
-
L
--------
D
---------
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
N
L
R
V
---
G
P
D
P
D
N
F
D
F
22
PsiBlast_CBE
93.39
67%
-91
- C5 -
3D3F
1
GR_BACSU
B:
[3-275]
-
S
L
K
D
T
V
K
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
----
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
D
--------------------
K
--------------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
---
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-----------
L
-
L
--------
D
---------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
---
G
P
N
P
D
E
L
L
F
3
PsiBlast_PDB
92.71
60%
-92
- C5 -
1VBJ
2
PGFS_TRYBB
A:
[6-277]
M
A
L
T
Q
S
L
K
L
-
S
N
G
V
M
M
P
V
L
G
F
G
M
W
---
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
----
S
----
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
D
--------------------
K
--------------------
F
I
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
---
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
----------
Q
-------
G
H
-----------
L
-
V
--------
E
---------
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
G
H
R
Y
---
G
P
D
P
E
V
F
--
102
HHSearch
92.37
61%
-91
- C5 -
1VBJ
2
PGFS_TRYBB
A:
[8-277]
--
L
T
Q
S
L
K
L
-
S
N
G
V
M
M
P
V
L
G
F
G
M
W
---
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
----
S
----
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
D
--------------------
K
--------------------
F
I
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
---
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
----------
Q
-------
G
H
-------------
L
V-------
E
---------
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
G
H
R
Y
---
G
P
D
P
E
V
F
--
103
HHSearch
92.31
59%
-88
- C5 -
3B3D
1
YTBE_BACSU
A:
[41-314]
-----
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
---
Q
V
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
----
E
G
I
E
E
A
-----
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
V
--------------------
E
--------------------
G
--------------------
K
--------------------
Y
K
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
---
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
----------
Q
-------
G
Q
-------------
L
L-------
D
---------
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
N
L
R
V
---
G
P
D
P
D
N
F
D
F
7
PsiBlast_PDB
91.28
58%
-91
- C5 -
4GIE
2
PGFS_TRYCC
A:
[14-284]
----
N
C
V
T
L
-
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
---
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
----
E
----
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
K
--------------------
K
--------------------
F
V
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
---
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
----------
S
-------
G
E
EAG--------
I
-
L
--------
K
---------
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
D
K
R
I
---
G
A
D
P
D
N
F
--
23
PsiBlast_CBE
91.09
60%
-88
- C5 -
1VBJ
2
PGFS_TRYBB
B:
[6-277]
M
A
L
T
Q
S
L
K
L
-
S
N
G
V
M
M
P
V
L
G
F
G
M
W
---
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
----
S
----
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
D
--------------------
K
--------------------
F
I
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
---
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
----------
Q
-------
G
H
-----------
L
-
V
--------
E
---------
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
G
H
R
Y
---
G
P
D
P
E
V
F
--
6
PsiBlast_PDB
90.49
58%
-88
- C5 -
4FZI
1
PGFS_TRYCC
A:
[14-284]
----
N
C
V
T
L
-
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
---
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
----
E
----
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
K
--------------------
K
--------------------
F
V
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
---
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
----------
S
-------
G
E
EAG--------
I
-
L
--------
K
---------
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
D
K
R
I
---
G
A
D
P
D
N
F
--
25
PsiBlast_CBE
90.29
59%
-92
- C5 -
4F40
10
PGFS_LEIMA
B:
[10-288]
---
K
A
M
V
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
---
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
---------------------
R
--------------------
G
--------------------
K
DILSKEGKK-----------
Y
L
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
---
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-------------------
K
-----------
L
-
L
--------
S
---------
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
N
S
R
Y
---
G
P
D
P
D
E
A
Q
F
4
PsiBlast_PDB
90.15
59%
-89
- C5 -
4F40
11
PGFS_LEIMA
A:
[10-288]
---
K
A
M
V
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
---
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
---------------------
R
--------------------
G
--------------------
K
D
I
L
S
K
EGKK-----------
Y
L
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
---
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-------------------
K
-----------
L
-
L
--------
S
---------
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
N
S
R
Y
---
G
P
D
P
D
E
A
Q
F
26
PsiBlast_CBE
90.06
58%
-93
- C5 -
4FZI
2
PGFS_TRYCC
B:
[14-284]
----
N
C
V
T
L
-
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
---
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
----
E
----
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
G
--------------------
K
--------------------
K
--------------------
K
--------------------
F
V
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
---
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
----------
S
--------------------
I
-
L
--------
K
---------
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
D
K
R
I
---
G
A
D
P
D
N
F
--
35
PsiBlast_CBE
89.63
50%
-97
- C5 -
4Q3M
1
?
C:
[3-274]
-----
S
V
K
L
-
N
N
N
Y
E
M
P
I
I
G
L
G
T
F
---
R
S
K
K
--
N
D
-
A
Y
N
A
V
K
A
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
I
K
----
D
----
S
-----
N
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
-
F
--------------------
K
--------------------
G
Y
D
------------------
N
--------------------
A
L
S
--------------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
A
---
K
I
P
--
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
M
----------
S
-------
H
Q
I
K
D
--------
L
-
L
--------
S
---------
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
E
E
D
M
K
S
I
R
S
V
N
-
T
G
K
K
I
---
F
T
E
F
D
N
V
D
Y
5
PsiBlast_PDB
89.52
59%
-87
- C5 -
4G5D
1
PGFS_LEIMA
A:
[10-288]
---
K
A
M
V
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
---
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
---------------------
R
--------------------
G
--------------------
K
D
I
L
S
K
EGKK-----------
Y
L
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
---
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
----------
Q
-------
G
K
-----------
L
-
L
--------
S
---------
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
N
S
R
Y
---
G
P
D
P
D
E
A
Q
F
24
PsiBlast_CBE
89.35
59%
-85
- C5 -
4G5D
1
PGFS_LEIMA
B:
[10-288]
---
K
A
M
V
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
---
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
---------------------
R
--------------------
G
--------------------
K
D
I
L
S
K
EGKK-----------
Y
L
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
---
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
----------
Q
-------
G
K
-----------
L
-
L
--------
S
---------
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
N
S
R
Y
---
G
P
D
P
D
E
A
Q
F
110
HHSearch
87.56
46%
-83
- C5 -
1MZR
4
DKGA_ECOLI
A:
[23-294]
-
A
N
P
T
V
I
K
L
-
Q
D
G
N
V
M
P
Q
L
G
L
G
V
W
---
Q
A
S
N
---
E
E
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
K
----
N
----
A
-----
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
--
D
D
H
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
V
--------------------
P
--------------------
A
ID------------------
H
--------------------
Y
V
E
--------------------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
T
---
G
V
T
--
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
----------
Q
-------
G
G
-------------
K
GVF-----
D
---------
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
K
D
E
L
G
E
I
A
K
L
D
-
Q
G
K
R
L
---
G
P
D
P
D
Q
F
--
13
PsiBlast_PDB
87.09
45%
-89
- C5 -
1MZR
4
DKGA_ECOLI
A:
[27-294]
-----
V
I
K
L
-
Q
D
G
N
V
M
P
Q
L
G
L
G
V
W
---
Q
A
S
N
---
E
E
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
K
----
N
----
A
-----
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
--
H
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
V
--------------------
P
--------------------
A
ID------------------
H
--------------------
Y
V
E
--------------------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
T
---
G
V
T
--
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
----------
Q
-------
G
G
KG---------
V
-
F
--------
D
---------
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
K
D
E
L
G
E
I
A
K
L
D
-
Q
G
K
R
L
---
G
P
D
P
D
Q
F
--
31
PsiBlast_CBE
86.16
55%
-100
- C5 -
3O0K
4
?
B:
[28-283]
-----
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
---
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
--------------------
P
--------------------
S
--------------------
K
D
L
------------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
---
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-------------------------------
L
-
L
--------
E
---------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
------------------
9
PsiBlast_PDB
85.81
55%
-96
- C5 -
3O0K
4
?
A:
[28-283]
-----
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
---
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
--------------------
P
--------------------
S
--------------------
K
D
L
------------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
---
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
----------
Q
-------
G
------------
L
-
L
--------
E
---------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
------------------
29
PsiBlast_CBE
85.70
55%
-93
- C5 -
3O0K
3
?
D:
[28-283]
-----
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
---
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
--------------------
P
--------------------
S
--------------------
K
DL------------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
---
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-------------------
K
-----------
L
-
L
--------
E
---------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
------------------
106
HHSearch
85.42
55%
-92
- C5 -
3O0K
4
?
A:
[25-282]
--
T
V
P
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
---
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
--------------------
P
--------------------
S
K
D
------------------
L
--------------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
---
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
----------
Q
-------
G
--------------
L
L-------
E
---------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
-------------------
30
PsiBlast_CBE
85.25
55%
-98
- C5 -
3O0K
3
?
C:
[28-283]
-----
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
---
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
--------------------
P
--------------------
S
--------------------
K
D
L
------------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
---
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-------------------------------
L
-
L
--------
E
---------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
------------------
41
PsiBlast_CBE
84.92
50%
-97
- C5 -
1VP5
1
?
B:
[18-278]
------
V
T
L
-
N
N
G
V
E
M
P
I
L
G
Y
G
V
F
---
Q
I
P
P
---
E
K
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
K
RAID
E
----
G
-----
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
F
-----------------------------------------
G
--------------------
D
--------------------
V
H
C
--------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
---
E
I
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
----------
E
-------
G
R
KN---------
I
-
F
--------
Q
---------
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
-
E
G
Q
--------------
16
PsiBlast_PDB
84.64
50%
-98
- C5 -
1VP5
1
?
A:
[18-278]
------
V
T
L
-
N
N
G
V
E
M
P
I
L
G
Y
G
V
F
---
Q
I
P
P
---
E
K
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
K
R
A
I
D
E
----
G
-----
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
F
-----------------------------------------
G
--------------------
D
--------------------
V
H
C
--------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
---
E
I
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
----------
E
-------
G
R
KN---------
I
-
F
--------
Q
---------
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
-
E
G
Q
--------------
108
HHSearch
84.13
50%
-85
- C5 -
1VP5
1
?
A:
[21-290]
----------
N
N
G
V
E
M
P
I
L
G
Y
G
V
F
---
Q
I
P
P
---
E
K
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
K
----
R
----
A
I
D
E
G-
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
F
--------------------
G
-----------------------------------------
D
--------------------
V
H
C
--------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
---
E
I
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
----------
E
-------
G
R
-------------
K
NIF-----
Q
---------
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
-
E
G
Q
S
A
FFS
H
R
D
P
E
V
V
--
101
HHSearch
83.69
49%
-84
- C5 -
2WZM
1
Y2407_MYCS2
A:
[10-281]
--
A
I
P
T
V
T
L
-
N
D
D
N
T
L
P
V
V
G
I
G
V
G
---
E
L
S
D
---
S
E
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
----
A
----
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
G
--------------------
G
--------------------
D
T
S
------------------
K
--------------------
Y
V
D
--------------------
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
T
---
Y
F
T
--
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
----------
V
-------
G
R
-------------
L
L-------
D
---------
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
-
D
G
T
R
F
---
R
P
D
P
A
T
Y
T
-
40
PsiBlast_CBE
83.46
44%
-91
- C5 -
3WBW
3
?
B:
[14-282]
---
Q
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
W
---
E
T
P
P
---
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
----
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
M
PA------------------
Q
--------------------
G
--------------------
Q
--------------------
Y
V
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
---
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
----------
K
-------
G
R
-----------
V
-
L
--------
S
---------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
R
M
---
G
A
D
P
N
T
A
K
F
11
PsiBlast_PDB
82.87
48%
-87
- C5 -
2WZM
1
Y2407_MYCS2
A:
[13-281]
-----
T
V
T
L
-
N
D
D
N
T
L
P
V
V
G
I
G
V
G
---
E
L
S
D
---
S
E
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
----
A
----
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
G
GD------------------
T
--------------------
S
--------------------
K
--------------------
Y
V
D
--------------------
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
T
---
Y
F
T
--
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
----------
V
-------
G
R
-----------
L
-
L
--------
D
---------
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
-
D
G
T
R
F
---
R
P
D
P
A
T
Y
T
-
37
PsiBlast_CBE
82.81
48%
-90
- C5 -
2WZM
1
Y2407_MYCS2
B:
[13-281]
-----
T
V
T
L
-
N
D
D
N
T
L
P
V
V
G
I
G
V
G
---
E
L
S
D
---
S
E
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
----
A
----
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
G
GD------------------
T
--------------------
S
--------------------
K
--------------------
Y
V
D
--------------------
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
T
---
Y
F
T
--
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
----------
V
-------
G
R
-----------
L
-
L
--------
D
---------
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
-
D
G
T
R
F
---
R
P
D
P
A
T
Y
T
-
14
PsiBlast_PDB
82.70
44%
-90
- C5 -
3WBW
2
?
A:
[14-282]
---
Q
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
W
---
E
T
P
P
---
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
----
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
M
PA------------------
Q
--------------------
G
--------------------
Q
--------------------
Y
V
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
---
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
----------
K
-------
G
R
-----------
V
-
L
--------
S
---------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
R
M
---
G
A
D
P
N
T
A
K
F
44
PsiBlast_CBE
82.46
36%
-95
- C5 -
4GAC
2
AK1A1_MOUSE
B:
[3-303]
----
S
S
V
L
L
-
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
---
K
S
E
P
--
G
-
Q
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
K
----
E
----
S
VGSGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
E
RGDNPFPKGTVRYD---
S
--------------------
T
--------------------
H
--------------------
Y
K
E
--------------------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
A
---
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G
--------------------PDEPV------
L
-
L
--------
E
---------
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
W
R
-------------
42
PsiBlast_CBE
82.08
44%
-87
- C5 -
3WBY
1
?
B:
[14-282]
---
Q
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
W
---
E
T
P
P
---
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
----
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
M
PA------------------
Q
--------------------
G
--------------------
Q
--------------------
Y
V
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
---
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
----------
K
-------
G
R
-----------
V
-
L
--------
S
---------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
R
M
---
G
A
D
P
N
T
A
K
F
46
PsiBlast_CBE
81.92
44%
-87
- C5 -
1M9H
2
DKGA_CORSC
A:
[5-268]
-----
S
I
V
L
-
N
D
G
N
S
I
P
Q
L
G
Y
G
V
Y
---
K
V
P
P
--
A
D
T
Q
-
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
----
A
----
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
T
--------------------
P
--------------------
A
AD------------------
N
--------------------
Y
V
H
--------------------
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
---
G
V
V
--
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
----------
Q
-------
G
K
YD---------
L
-
F
--------
G
---------
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
G
S
V
R
R
E
H
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
-
P
G
D
G
S
---
G
--------
117
HHSearch
81.19
39%
-80
- C5 -
3H7U
2
AKRC9_ARATH
A:
[24-312]
--
A
I
T
F
F
K
L
-
N
T
G
A
K
F
P
S
V
G
L
G
T
W
---
Q
A
S
P
---
G
L
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
K
----
K
----
L
F
E
D
R-
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
A
--------------------
R
--------------------
I
K
K
GSVGIKPENLLPV-----
D
--------------------
I
P
S
--------------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
A
---
R
V
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
G
----------
S
-------
P
G
-------------
T
TWLKSDVL
K
---------
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
D
Y
M
F
A
K
F
A
E
I
E
-
Q
A
-
R
L
---
V
T
-------
43
PsiBlast_CBE
81.17
44%
-86
- C5 -
1A80
1
DKGA_CORSC
A:
[4-267]
-----
S
I
V
L
-
N
D
G
N
S
I
P
Q
L
G
Y
G
V
F
---
K
V
P
P
--
A
D
T
Q
-
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
----
A
----
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
T
--------------------
P
--------------------
A
AD------------------
N
--------------------
Y
V
H
--------------------
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
---
G
V
V
--
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
----------
Q
-------
G
K
YD---------
L
-
F
--------
G
---------
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
-
P
G
D
G
S
---
G
--------
17
PsiBlast_PDB
81.01
44%
-87
- C5 -
3WBY
2
?
A:
[14-282]
---
Q
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
W
---
E
T
P
P
---
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
----
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
M
PA------------------
Q
--------------------
G
--------------------
Q
--------------------
Y
V
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
---
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
----------
K
-------
G
R
-----------
V
-
L
--------
S
---------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
R
M
---
G
A
D
P
N
T
A
K
F
61
PsiBlast_CBE
80.57
37%
-91
- C5 -
3H7U
2
AKRC9_ARATH
A:
[29-303]
-------
K
L
-
N
T
G
A
K
F
P
S
V
G
L
G
T
W
---
Q
A
S
P
--
G
L
V
G
-
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
K
K
L
F
E
D
----
R
-----
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
A
--------------------
R
--------------------
I
--------------------
K
K
GSVGIKPENLLPVD-----
I
P
S
--------------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
A
---
R
V
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
G
----------
S
PGTTWLK
S
D
-----------
V
-
L
--------
K
---------
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
D
Y
M
F
A
K
F
A
---------------------
45
PsiBlast_CBE
80.57
36%
-91
- C5 -
4GAC
2
AK1A1_MOUSE
A:
[3-296]
----
S
S
V
L
L
-
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
---
K
S
E
P
--
G
-
Q
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
K
----
E
----
S
VGSGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGDNPFPKNADG
T
V
R
Y
D
S
--------------------
T
--------------------
H
--------------------
Y
K
E
--------------------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
A
---
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G
----------
S
-------
S
D
RAWRHPDEPV-
L
-
L
--------
E
---------
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
W
R
-------------
56
PsiBlast_CBE
80.42
36%
-88
- C5 -
3FX4
5
AK1A1_PIG
A:
[4-297]
----
S
C
V
L
L
-
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
---
K
S
E
P
--
G
-
Q
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
----
E
----
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
--------------------
A
F
ERGDNP
F
P
K
N
ADG
T
I
R
Y
D
A
T
--------------------
H
--------------------
Y
K
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
---
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
----------
S
-------
S
D
RAWRDPNEPV-
L
-
L
--------
E
---------
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
L
R
-------------
51
PsiBlast_CBE
80.42
38%
-94
- C5 -
4JII
3
AK1BA_HUMAN
X:
[7-300]
------
V
E
L
-
S
T
K
A
K
M
P
I
V
G
L
G
T
W
---
K
S
P
L
--
G
-
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
----
K
IQEK-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
GFKSGDDLFPKDDKGNAIGG
K
--------------------
A
--------------------
T
--------------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL-
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRPWAKPE
D
-------
P
S
-----------
L
-
L
--------
E
---------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
------------
64
PsiBlast_CBE
79.83
38%
-95
- C5 -
4JTQ
9
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
49
PsiBlast_CBE
79.77
38%
-92
- C5 -
1ZUA
2
AK1BA_HUMAN
X:
[6-299]
------
V
E
L
-
S
T
K
A
K
M
P
I
V
G
L
G
T
W
---
K
S
P
L
--
G
-
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
----
K
IQEK-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
GFKSGDDLFPKDDKGNAIGG
K
--------------------
A
--------------------
T
--------------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL-
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRPWAKPE
D
-------
P
S
-----------
L
-
L
--------
E
---------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
------------
48
PsiBlast_CBE
79.77
38%
-93
- C5 -
4GA8
2
AK1BA_HUMAN
A:
[5-298]
------
V
E
L
-
S
T
K
A
K
M
P
I
V
G
L
G
T
W
---
K
S
P
L
--
G
-
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
----
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
G
G
K
--------------------
A
--------------------
T
--------------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL-
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRPWAKPE
D
-------
P
S
-----------
L
-
L
--------
E
---------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
------------
112
HHSearch
79.76
44%
-86
- C5 -
3WBW
2
?
A:
[14-278]
---
Q
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
W
---
E
T
P
P
---
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
-----------------
D
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
M
--------------------
P
--------------------
A
QG------------------
Q
--------------------
Y
V
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
---
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
----------
K
-------
G
R
-------------
V
L-------
S
---------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
-
R
K
D
G
R
---
M
G
A
D
P
N
---
75
PsiBlast_CBE
79.69
38%
-93
- C5 -
4JQ1
4
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKI
L
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
82
PsiBlast_CBE
79.66
38%
-90
- C5 -
2HDJ
7
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
SKIA
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKILFDTVD
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
50
PsiBlast_CBE
79.66
38%
-93
- C5 -
4JIH
2
AK1BA_HUMAN
A:
[7-300]
------
V
E
L
-
S
T
K
A
K
M
P
I
V
G
L
G
T
W
---
K
S
P
L
--
G
-
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
----
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
GFKSGDDL
F
P
K
D
DKG
N
A
I
G
G
K
--------------------
A
--------------------
T
--------------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL-
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRPWAKPE
D
-------
P
S
-----------
L
-
L
--------
E
---------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
------------
47
PsiBlast_CBE
79.66
38%
-92
- C5 -
4GAB
3
AK1BA_HUMAN
A:
[5-298]
------
V
E
L
-
S
T
K
A
K
M
P
I
V
G
L
G
T
W
---
K
S
P
L
--
G
-
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
----
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
G
G
K
--------------------
A
--------------------
T
--------------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL-
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRPWAKPE
D
-------
P
S
-----------
L
-
L
--------
E
---------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
------------
63
PsiBlast_CBE
79.62
38%
-92
- C5 -
4JTR
5
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
81
PsiBlast_CBE
79.58
38%
-89
- C5 -
1XJB
6
AK1C2_HUMAN
A:
[9-306]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKI
L
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
60
PsiBlast_CBE
79.50
36%
-83
- C5 -
1HQT
1
AK1A1_PIG
A:
[5-298]
----
S
C
V
L
L
-
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
---
K
S
E
P
--
G
-
Q
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
F
G
N
E
L
E
I
G
E
A
L
Q
----
E
----
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
--------------------
A
F
ERGDNP
F
P
K
N
ADGTIR
Y
D
A
T
--------------------
H
--------------------
Y
K
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
---
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
----------
S
-------
S
D
RA
W
R
D
P
N
E
PV-
L
-
L
--------
E
---------
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
L
R
-------------
76
PsiBlast_CBE
79.44
38%
-90
- C5 -
1J96
3
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKI
L
F
D
T
V
D-----
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
65
PsiBlast_CBE
79.43
38%
-92
- C5 -
4JTQ
4
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
P
G
EEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
66
PsiBlast_CBE
79.38
38%
-91
- C5 -
4JQA
7
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
71
PsiBlast_CBE
79.33
38%
-89
- C5 -
4JQ3
4
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
P
G
EEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
69
PsiBlast_CBE
79.18
38%
-93
- C5 -
4JQ4
5
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
67
PsiBlast_CBE
79.13
38%
-92
- C5 -
4JQA
5
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
79
PsiBlast_CBE
79.05
38%
-93
- C5 -
4L1W
4
AK1C2_HUMAN
A:
[9-306]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
78
PsiBlast_CBE
79.05
38%
-91
- C5 -
4L1W
3
AK1C2_HUMAN
B:
[9-306]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
SKIA
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKILFDTVD
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
57
PsiBlast_CBE
79.05
36%
-87
- C5 -
3CV7
5
AK1A1_PIG
A:
[4-300]
----
S
C
V
L
L
-
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
---
K
S
E
P
--
G
-
Q
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
----
E
----
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
--------------------
A
F
ERGDNP
F
P
K
N
ADG
T
I
R
Y
D
A
T
--------------------
H
--------------------
Y
K
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
---
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
----------
S
-------
S
D
RAWRDPNEPV-
L
-
L
--------
E
---------
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
L
R
-------------
73
PsiBlast_CBE
79.00
38%
-91
- C5 -
4JQ2
5
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
80
PsiBlast_CBE
78.99
38%
-90
- C5 -
1XJB
5
AK1C2_HUMAN
B:
[9-306]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
62
PsiBlast_CBE
78.92
38%
-92
- C5 -
4JTR
7
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
77
PsiBlast_CBE
78.87
38%
-91
- C5 -
1J96
3
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKI
L
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
70
PsiBlast_CBE
78.81
38%
-90
- C5 -
4JQ3
8
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
54
PsiBlast_CBE
78.78
38%
-93
- C5 -
4I5X
2
AK1BA_HUMAN
A:
[7-300]
------
V
E
L
-
S
T
K
A
K
M
P
I
V
G
L
G
T
W
---
K
S
P
L
--
G
-
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
----
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDLFPKDDKG
N
A
I
G
G
K
--------------------
A
--------------------
T
--------------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL-
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRPWAKPE
D
-------
P
S
-----------
L
-
L
--------
E
---------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
------------
55
PsiBlast_CBE
78.76
36%
-86
- C5 -
3H4G
3
AK1A1_PIG
A:
[4-301]
----
S
C
V
L
L
-
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
---
K
S
E
P
--
G
-
Q
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
----
E
----
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
--------------------
A
F
E
RGDNP
F
P
K
N
ADGTIRYDA
T
--------------------
H
--------------------
Y
K
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
---
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
----------
S
-------
S
D
RAWRDPNEPV-
L
-
L
--------
E
---------
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
L
R
-------------
72
PsiBlast_CBE
78.74
38%
-92
- C5 -
4JQ2
7
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
53
PsiBlast_CBE
78.65
38%
-95
- C5 -
4GQ0
2
AK1BA_HUMAN (first)
A:
[7-300]
------
V
E
L
-
S
T
K
A
K
M
P
I
V
G
L
G
T
W
---
K
S
P
L
--
G
-
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
----
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
G
G
K
--------------------
A
--------------------
T
--------------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL-
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRPWAKPE
D
-------
P
S
-----------
L
-
L
--------
E
---------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
------------
83
PsiBlast_CBE
78.55
38%
-88
- C5 -
2HDJ
5
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
P
G
EEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
88
PsiBlast_CBE
78.52
38%
-88
- C5 -
2IPJ
10
AK1C2_HUMAN
B:
[5-302]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
A
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
SKIA
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKILFDTVD
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
86
PsiBlast_CBE
78.46
38%
-91
- C5 -
4L1X
3
AK1C2_HUMAN
B:
[9-306]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
SKIA
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKILFDTVD
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
52
PsiBlast_CBE
78.40
38%
-92
- C5 -
4GQG
1
AK1BA_HUMAN
A:
[7-300]
------
V
E
L
-
S
T
K
A
K
M
P
I
V
G
L
G
T
W
---
K
S
P
L
--
G
-
K
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
----
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
GFKSGDDL
F
P
K
D
DKG
N
A
I
G
G
K
--------------------
A
--------------------
T
--------------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL-
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
SPDRPWAKPE
D
-------
P
S
-----------
L
-
L
--------
E
---------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
------------
92
PsiBlast_CBE
78.24
37%
-89
- C5 -
3C3U
3
AK1C1_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
---
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
85
PsiBlast_CBE
78.06
38%
-86
- C5 -
1IHI
2
AK1C2_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
74
PsiBlast_CBE
77.92
38%
-91
- C5 -
4JQ1
5
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
SKIA
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKILFDTVD
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
89
PsiBlast_CBE
77.89
38%
-89
- C5 -
2IPJ
8
AK1C2_HUMAN
A:
[5-302]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
A
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
87
PsiBlast_CBE
77.85
38%
-90
- C5 -
4L1X
4
AK1C2_HUMAN
A:
[9-306]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
116
HHSearch
77.75
43%
-80
- C5 -
1US0
4
ALDR_HUMAN
A:
[1-300]
---
M
A
S
R
I
L
L
N
N
G
A
K
M
P
I
L
G
L
G
T
W
---
K
S
P
P
---
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
Q
----
E
----
K
L
R
E
Q-
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
T
--------------------
G
--------------------
F
KPGKEF
F
P
L
D
ESGNVVPSDT
N
--------------------
I
L
D
--------------------
T
W
A
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
N
H
L
Q
V
E
M
I
L
N
K
P
GL-
K
Y
K
--
P
A
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
----------
S
-------
P
D
-------------
R
PW------
A
KPEDPSLLE
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
N
L
V
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
K
V
F
D
F
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
-
R
N
W
R
V
---
C
A
-------
90
PsiBlast_CBE
77.75
37%
-95
- C5 -
3GUG
3
AK1C1_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENG
K
I
L
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
---
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
84
PsiBlast_CBE
77.70
38%
-86
- C5 -
1IHI
2
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
SKIA
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEVIPKDENGKILFDTVD
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
91
PsiBlast_CBE
77.61
37%
-87
- C5 -
3NTY
3
AK1C1_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENG
K
I
L
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
---
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
68
PsiBlast_CBE
77.28
38%
-91
- C5 -
4JQ4
7
AK1C2_HUMAN
B:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
-
H
R
L
L
E
M
I
L
N
K
PGL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
-PWVDPNSPV--
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
96
PsiBlast_CBE
77.22
36%
-91
- C5 -
3UZY
3
AK1D1_HUMAN
B:
[30-327]
------
I
P
L
-
S
D
G
N
S
I
P
I
I
G
L
G
T
Y
SEP
K
S
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
----
E
KIAE
G
-----
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
M
--------------------
A
--------------------
F
--------------------
K
--------------------
P
G
D
EIYPRDENGKWLYHKSNLCA
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
---
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
G
----------
T
-------
S
R
NPIWVNVSSPP
L
-
L
--------
K
---------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
-------------
98
PsiBlast_CBE
77.11
36%
-91
- C5 -
3UZX
5
AK1D1_HUMAN
B:
[30-327]
------
I
P
L
-
S
D
G
N
S
I
P
I
I
G
L
G
T
Y
SEP
K
S
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
----
E
KIAE
G
-----
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
M
--------------------
A
--------------------
F
--------------------
K
--------------------
P
G
D
EIYPRDENGKWLYHKSNLCA
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
---
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
G
----------
T
-------
S
R
NPIWVNVSSPP
L
-
L
--------
K
---------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
-------------
94
PsiBlast_CBE
76.85
36%
-90
- C5 -
3UZZ
2
AK1D1_HUMAN
B:
[30-327]
------
I
P
L
-
S
D
G
N
S
I
P
I
I
G
L
G
T
Y
SEP
K
S
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
----
E
KIAE
G
-----
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
M
--------------------
A
--------------------
F
--------------------
K
--------------------
P
G
D
EIYPRDENGKWLYHKSNLCA
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
---
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
G
----------
T
-------
S
R
NPIWVNVSSPP
L
-
L
--------
K
---------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
-------------
93
PsiBlast_CBE
76.56
37%
-90
- C5 -
1MRQ
3
AK1C1_HUMAN
A:
[7-304]
-----
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
---
A
P
A
E
VP
K
S
K
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
V
--------------------
S
--------------------
V
--------------------
K
PGEEV
I
P
K
D
ENG
K
I
L
F
D
T
V
D
L
C
A
--------------------
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
---
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
----------
S
-------
H
R
EEPWVDPNSPV
L
-
L
--------
E
---------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-------------
100
PsiBlast_CBE
76.48
36%
-92
- C5 -
3UZW
3
AK1D1_HUMAN
B:
[30-327]
------
I
P
L
-
S
D
G
N
S
I
P
I
I
G
L
G
T
Y
SEP
K
S
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
----
E
KIAE
G
-----
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
M
--------------------
A
--------------------
F
--------------------
K
--------------------
P
G
D
EIYPRDENGKWLYHKSNLCA
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
---
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
G
----------
T
-------
S
R
NPIWVNVSSPP
L
-
L
--------
K
---------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
-------------
97
PsiBlast_CBE
75.95
36%
-92
- C5 -
3UZY
3
AK1D1_HUMAN
A:
[30-327]
------
I
P
L
-
S
D
G
N
S
I
P
I
I
G
L
G
T
Y
SEP
K
S
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
----
E
K
I
A
E
G
-----
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
M
--------------------
A
--------------------
F
--------------------
K
--------------------
P
G
D
EI
Y
P
R
D
ENG
K
W
L
Y
H
KSN
L
C
A
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
---
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
G
----------
T
-------
S
R
NPIWVNVSSPP
L
-
L
--------
K
---------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
-------------
99
PsiBlast_CBE
75.80
36%
-91
- C5 -
3UZX
3
AK1D1_HUMAN
A:
[30-327]
------
I
P
L
-
S
D
G
N
S
I
P
I
I
G
L
G
T
Y
SEP
K
S
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
----
E
K
I
A
E
G
-----
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
M
--------------------
A
--------------------
F
--------------------
K
--------------------
P
G
D
EI
Y
P
R
D
ENGKWLYHKSN
L
C
A
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
---
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
G
----------
T
-------
S
R
NPIWVNVSSPP
L
-
L
--------
K
---------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
-------------
95
PsiBlast_CBE
75.33
36%
-90
- C5 -
3UZZ
3
AK1D1_HUMAN
A:
[30-327]
------
I
P
L
-
S
D
G
N
S
I
P
I
I
G
L
G
T
Y
SEP
K
S
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
----
E
K
I
A
E
G
-----
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
M
--------------------
A
--------------------
F
--------------------
K
--------------------
P
G
D
EI
Y
P
R
D
ENGKWLYHKSN
L
C
A
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
---
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
G
----------
T
-------
S
R
NPIWVNVSSPP
L
-
L
--------
K
---------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
-------------
121
HHSearch
74.86
37%
-72
- C5 -
2BGS
4
ALDR_HORVU
A:
[37-319]
----
Q
D
H
F
V
L
K
S
G
H
A
M
P
A
V
G
L
G
T
W
---
R
A
G
S
---
D
T
A
H
S
V
R
T
A
I
T
E
A
G
Y
R
H
V
D
T
A
A
E
Y
G
V
E
K
E
V
G
K
G
L
K
----
A
----
A
M
E
A
--
G
I
D
R
K
D
L
F
V
T
S
K
I
W
C
T
N
L
A
P
E
R
V
R
P
A
L
E
N
T
L
K
D
L
Q
L
D
Y
I
D
L
Y
H
I
H
W
P
F
--------------------
R
--------------------
L
K
DGAHMPPEAGE
V
L
E
F
----
D
--------------------
M
E
G
--------------------
V
W
K
E
M
E
N
L
V
K
D
G
L
V
K
D
I
G
V
C
N
Y
T
V
T
K
L
N
R
L
L
R
S
A
---
K
I
P
--
P
A
V
C
Q
M
E
M
H
P
G
W
K
N
D
K
I
F
E
A
C
K
K
H
G
I
H
I
T
A
Y
S
P
L
G
----------
S
-------
S
E
-----------
K
N
L
A-------
H
---------
D
P
V
V
E
K
V
A
N
K
L
N
K
T
P
G
Q
V
L
I
K
W
A
L
Q
R
G
T
S
V
I
P
K
S
S
K
D
E
R
I
K
E
N
I
Q
V
F
G
W
E
I
P
E
E
D
F
K
V
L
C
S
I
K
-
D
E
K
R
V
---
L
--------